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Aliases for NECTIN4 Gene

Aliases for NECTIN4 Gene

  • Nectin Cell Adhesion Molecule 4 2 3
  • Poliovirus Receptor-Related 4 2 3 5
  • PVRL4 3 4 5
  • Poliovirus Receptor-Related Protein 4 3 4
  • Ig Superfamily Receptor LNIR 3 4
  • LNIR 3 4
  • PRR4 3 4
  • Nectin 4 3
  • Nectin-4 3
  • EDSS1 3

External Ids for NECTIN4 Gene

Previous HGNC Symbols for NECTIN4 Gene

  • PVRL4

Summaries for NECTIN4 Gene

Entrez Gene Summary for NECTIN4 Gene

  • This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

GeneCards Summary for NECTIN4 Gene

NECTIN4 (Nectin Cell Adhesion Molecule 4) is a Protein Coding gene. Diseases associated with NECTIN4 include ectodermal dysplasia-syndactyly syndrome 1 and ectodermal dysplasia-syndactyly syndrome. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Adherens junction. An important paralog of this gene is NECTIN3.

UniProtKB/Swiss-Prot for NECTIN4 Gene

  • Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.

  • (Microbial infection) Acts as a receptor for measles virus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECTIN4 Gene

Genomics for NECTIN4 Gene

Regulatory Elements for NECTIN4 Gene

Promoters for NECTIN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NECTIN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NECTIN4 Gene

Chromosome:
1
Start:
161,070,991 bp from pter
End:
161,089,599 bp from pter
Size:
18,609 bases
Orientation:
Minus strand

Genomic View for NECTIN4 Gene

Genes around NECTIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECTIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECTIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECTIN4 Gene

Proteins for NECTIN4 Gene

  • Protein details for NECTIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NY8-PVRL4_HUMAN
    Recommended name:
    Nectin-4
    Protein Accession:
    Q96NY8
    Secondary Accessions:
    • B4DQW3
    • Q96K15

    Protein attributes for NECTIN4 Gene

    Size:
    510 amino acids
    Molecular mass:
    55454 Da
    Quaternary structure:
    • Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C-terminus with MLLT4.
    • (Microbial infection) Interacts with measles virus Hemagglutinin protein (PubMed:22048310, PubMed:23202587).

    Three dimensional structures from OCA and Proteopedia for NECTIN4 Gene

    Alternative splice isoforms for NECTIN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NECTIN4 Gene

Proteomics data for NECTIN4 Gene at MOPED

Post-translational modifications for NECTIN4 Gene

  • The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NECTIN4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NECTIN4 Gene

Domains & Families for NECTIN4 Gene

Gene Families for NECTIN4 Gene

Protein Domains for NECTIN4 Gene

Suggested Antigen Peptide Sequences for NECTIN4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NY8

UniProtKB/Swiss-Prot:

PVRL4_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the nectin family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with NECTIN4: view

Function for NECTIN4 Gene

Molecular function for NECTIN4 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for measles virus.

Gene Ontology (GO) - Molecular Function for NECTIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with NECTIN4: view
genes like me logo Genes that share phenotypes with NECTIN4: view

Human Phenotype Ontology for NECTIN4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NECTIN4 Gene

Localization for NECTIN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECTIN4 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=Colocalizes with MLLT4 at cadherin-based adherens junctions (PubMed:11544254).
Processed poliovirus receptor-related protein 4: Secreted. Note=The secreted form is found in breast tumor patients (PubMed:15784625).

Gene Ontology (GO) - Cellular Components for NECTIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005913 cell-cell adherens junction IBA --
genes like me logo Genes that share ontologies with NECTIN4: view

No data available for Subcellular locations from COMPARTMENTS for NECTIN4 Gene

Pathways & Interactions for NECTIN4 Gene

genes like me logo Genes that share pathways with NECTIN4: view

Gene Ontology (GO) - Biological Process for NECTIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with NECTIN4: view

No data available for SIGNOR curated interactions for NECTIN4 Gene

Drugs & Compounds for NECTIN4 Gene

(1) Drugs for NECTIN4 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ASG-22ME Pharma antibody 0
genes like me logo Genes that share compounds with NECTIN4: view

Transcripts for NECTIN4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NECTIN4 Gene

No ASD Table

Relevant External Links for NECTIN4 Gene

GeneLoc Exon Structure for
NECTIN4
ECgene alternative splicing isoforms for
NECTIN4

Expression for NECTIN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for NECTIN4 Gene

Q96NY8-PVRL4_HUMAN
Tissue specificity: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.
genes like me logo Genes that share expression patterns with NECTIN4: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NECTIN4 Gene

Orthologs for NECTIN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECTIN4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PVRL4 35
  • 89.48 (n)
  • 91.76 (a)
PVRL4 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PVRL4 35
  • 90.04 (n)
  • 94.02 (a)
PVRL4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pvrl4 35
  • 87.73 (n)
  • 92.52 (a)
Nectin4 16
Pvrl4 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PVRL4 35
  • 99.67 (n)
  • 100 (a)
PVRL4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pvrl4 35
  • 88.39 (n)
  • 94.09 (a)
oppossum
(Monodelphis domestica)
Mammalia PVRL4 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PVRL4 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13547 35
zebrafish
(Danio rerio)
Actinopterygii LOC560512 35
  • 48.81 (n)
  • 37.09 (a)
pvrl4 36
  • 26 (a)
OneToMany
PVRL4 (2 of 3) 36
  • 23 (a)
OneToMany
PVRL4 (3 of 3) 36
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for NECTIN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECTIN4 Gene

ENSEMBL:
Gene Tree for NECTIN4 (if available)
TreeFam:
Gene Tree for NECTIN4 (if available)

Paralogs for NECTIN4 Gene

Paralogs for NECTIN4 Gene

genes like me logo Genes that share paralogs with NECTIN4: view

Variants for NECTIN4 Gene

Sequence variations from dbSNP and Humsavar for NECTIN4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1344347 -- 161,073,048(+) GTGTT(A/G)GGCAT intron-variant
rs1411614 -- 161,088,119(+) ATAAT(A/G)AAATC intron-variant
rs1467742 -- 161,081,061(-) GTGGT(C/T)CCTGA intron-variant
rs1537044 -- 161,072,867(-) AGGGC(C/T)GCAGT reference, missense, utr-variant-3-prime
rs1556257 -- 161,081,344(-) CTAGC(A/G)CTACT intron-variant

Variation tolerance for NECTIN4 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NECTIN4 Gene

HapMap Linkage Disequilibrium report
NECTIN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NECTIN4 Gene

Disorders for NECTIN4 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NECTIN4 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ectodermal dysplasia-syndactyly syndrome 1
  • edss1
ectodermal dysplasia-syndactyly syndrome
  • ectodermal dysplasia-syndactyly syndrome 1
measles
  • morbilli
syndactyly
  • chromosome 2q35 duplication syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PVRL4_HUMAN
  • Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1) [MIM:613573]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating. {ECO:0000269 PubMed:20691405}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NECTIN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NECTIN4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NECTIN4
genes like me logo Genes that share disorders with NECTIN4: view

No data available for Genatlas for NECTIN4 Gene

Publications for NECTIN4 Gene

  1. Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. (PMID: 11544254) Reymond N. … Lopez M. (J. Biol. Chem. 2001) 2 3 4 67
  2. Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. (PMID: 19679554) Takano A. … Daigo Y. (Cancer Res. 2009) 3 23
  3. Nectin-4 is a new histological and serological tumor associated marker for breast cancer. (PMID: 17474988) Fabre-Lafay S. … Lopez M. (BMC Cancer 2007) 3 23
  4. Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. (PMID: 15784625) Fabre-Lafay S. … Lopez M. (J. Biol. Chem. 2005) 3 23
  5. A novel homozygous nonsense mutation in the PVRL4 gene and expansion of clinical spectrum of EDSS1. (PMID: 25529316) Raza S.I. … Ahmad W. (Ann. Hum. Genet. 2015) 3

Products for NECTIN4 Gene

Sources for NECTIN4 Gene

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