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Aliases for NECTIN4 Gene

Aliases for NECTIN4 Gene

  • Nectin Cell Adhesion Molecule 4 2 3 4 5
  • Poliovirus Receptor-Related Protein 4 3 4
  • Poliovirus Receptor-Related 4 2 3
  • Ig Superfamily Receptor LNIR 3 4
  • PVRL4 3 4
  • LNIR 3 4
  • PRR4 3 4
  • Nectin 4 3
  • Nectin-4 3
  • EDSS1 3

External Ids for NECTIN4 Gene

Previous HGNC Symbols for NECTIN4 Gene

  • PVRL4

Summaries for NECTIN4 Gene

Entrez Gene Summary for NECTIN4 Gene

  • This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]

GeneCards Summary for NECTIN4 Gene

NECTIN4 (Nectin Cell Adhesion Molecule 4) is a Protein Coding gene. Diseases associated with NECTIN4 include Ectodermal Dysplasia-Syndactyly Syndrome 1 and Measles. Among its related pathways are Cell junction organization and Adherens junction. An important paralog of this gene is NECTIN3.

UniProtKB/Swiss-Prot for NECTIN4 Gene

  • Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

  • (Microbial infection) Acts as a receptor for measles virus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECTIN4 Gene

Genomics for NECTIN4 Gene

Regulatory Elements for NECTIN4 Gene

Enhancers for NECTIN4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F161079 1.1 FANTOM5 Ensembl ENCODE 15.3 +4.8 4831 11.3 PKNOX1 ATF1 BRCA1 ZNF121 GLIS2 FOS ZNF263 SP3 ZHX2 NCOA1 F11R NECTIN4 DUSP12 TSTD1 NCSTN USF1 LOC105371471
GH01F161043 0.4 ENCODE 12.2 +42.7 42711 5.8 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D ARHGAP30 TSTD1 LOC105371471 NECTIN4 KLHDC9 CD48 DUSP12 UFC1 USP21 ENSG00000224985
GH01F161066 1 FANTOM5 ENCODE 12 +21.0 20985 5.1 HDGF PKNOX1 WRNIP1 SIN3A YY1 GLIS2 ELK1 ZNF143 ZNF207 SP3 FCGR2A TSTD1 DUSP12 ENSG00000228606 ARHGAP30 F11R DEDD ATF6 NECTIN4 ENSG00000232879
GH01F161041 0.2 ENCODE 11 +47.9 47937 1.1 HDGF CTCF ZNF362 JUNB TRIM22 REST ZNF48 RAD21 ATF2 CREB3 TSTD1 F11R KLHDC9 ARHGAP30 LOC105371471 NECTIN4 DEDD PIR33280
GH01F161037 0.2 ENCODE 11 +50.8 50846 2.2 HDGF ATF1 PKNOX1 SIN3A ZNF2 YY1 ZNF121 ZNF766 GLIS2 ELK1 F11R TSTD1 LOC105371471 ARHGAP30 NECTIN4 ENSG00000232879 ENSG00000270149
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NECTIN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NECTIN4 Gene

Chromosome:
1
Start:
161,070,991 bp from pter
End:
161,089,599 bp from pter
Size:
18,609 bases
Orientation:
Minus strand

Genomic View for NECTIN4 Gene

Genes around NECTIN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECTIN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECTIN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECTIN4 Gene

Proteins for NECTIN4 Gene

  • Protein details for NECTIN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NY8-NECT4_HUMAN
    Recommended name:
    Nectin-4
    Protein Accession:
    Q96NY8
    Secondary Accessions:
    • B4DQW3
    • Q96K15

    Protein attributes for NECTIN4 Gene

    Size:
    510 amino acids
    Molecular mass:
    55454 Da
    Quaternary structure:
    • Self-associates. Interacts via its Ig-like V-type domain with NECTIN1 Ig-like V-type domain. Interacts via its C-terminus with AFDN.
    • (Microbial infection) Interacts with measles virus Hemagglutinin protein (PubMed:22048310, PubMed:23202587).

    Three dimensional structures from OCA and Proteopedia for NECTIN4 Gene

    Alternative splice isoforms for NECTIN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NECTIN4 Gene

Post-translational modifications for NECTIN4 Gene

  • The soluble form is produced by proteolytic cleavage at the cell surface (shedding), probably by ADAM17/TACE.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NECTIN4 Gene

Antibody Products

  • Abcam antibodies for NECTIN4
  • Cloud-Clone Corp. Antibodies for NECTIN4

No data available for DME Specific Peptides for NECTIN4 Gene

Domains & Families for NECTIN4 Gene

Gene Families for NECTIN4 Gene

Suggested Antigen Peptide Sequences for NECTIN4 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NY8

UniProtKB/Swiss-Prot:

NECT4_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the nectin family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with NECTIN4: view

Function for NECTIN4 Gene

Molecular function for NECTIN4 Gene

UniProtKB/Swiss-Prot Function:
Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for measles virus.

Gene Ontology (GO) - Molecular Function for NECTIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0004872 receptor activity IBA --
GO:0005102 receptor binding IBA --
GO:0005515 protein binding IPI 21982860
GO:0042803 protein homodimerization activity IBA --
genes like me logo Genes that share ontologies with NECTIN4: view
genes like me logo Genes that share phenotypes with NECTIN4: view

Human Phenotype Ontology for NECTIN4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NECTIN4 Gene

Localization for NECTIN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECTIN4 Gene

Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=Colocalizes with AFDN at cadherin-based adherens junctions (PubMed:11544254).
Processed poliovirus receptor-related protein 4: Secreted. Note=The secreted form is found in breast tumor patients (PubMed:15784625).

Gene Ontology (GO) - Cellular Components for NECTIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0005911 cell-cell junction IDA 25468996
GO:0005912 adherens junction IEA --
genes like me logo Genes that share ontologies with NECTIN4: view

No data available for Subcellular locations from COMPARTMENTS for NECTIN4 Gene

Pathways & Interactions for NECTIN4 Gene

genes like me logo Genes that share pathways with NECTIN4: view

Gene Ontology (GO) - Biological Process for NECTIN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0008037 cell recognition IBA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with NECTIN4: view

No data available for SIGNOR curated interactions for NECTIN4 Gene

Drugs & Compounds for NECTIN4 Gene

(1) Drugs for NECTIN4 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ASG-22ME Pharma antibody 0
genes like me logo Genes that share compounds with NECTIN4: view

Transcripts for NECTIN4 Gene

Unigene Clusters for NECTIN4 Gene

Poliovirus receptor-related 4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NECTIN4 Gene

No ASD Table

Relevant External Links for NECTIN4 Gene

GeneLoc Exon Structure for
NECTIN4
ECgene alternative splicing isoforms for
NECTIN4

Expression for NECTIN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of NECTIN4 Gene:

NECTIN4

SOURCE GeneReport for Unigene cluster for NECTIN4 Gene:

Hs.492490

mRNA Expression by UniProt/SwissProt for NECTIN4 Gene:

Q96NY8-NECT4_HUMAN
Tissue specificity: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.
genes like me logo Genes that share expression patterns with NECTIN4: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NECTIN4 Gene

Orthologs for NECTIN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECTIN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PVRL4 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia PVRL4 34 35
  • 90.04 (n)
cow
(Bos Taurus)
Mammalia PVRL4 34 35
  • 89.48 (n)
rat
(Rattus norvegicus)
Mammalia Pvrl4 34
  • 88.39 (n)
mouse
(Mus musculus)
Mammalia Pvrl4 34 35
  • 87.73 (n)
Nectin4 16
oppossum
(Monodelphis domestica)
Mammalia PVRL4 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PVRL4 35
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13547 34
zebrafish
(Danio rerio)
Actinopterygii LOC560512 34
  • 48.81 (n)
pvrl4 35
  • 26 (a)
OneToMany
PVRL4 (2 of 3) 35
  • 23 (a)
OneToMany
PVRL4 (3 of 3) 35
  • 14 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 16 (a)
OneToMany
Species where no ortholog for NECTIN4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECTIN4 Gene

ENSEMBL:
Gene Tree for NECTIN4 (if available)
TreeFam:
Gene Tree for NECTIN4 (if available)

Paralogs for NECTIN4 Gene

Paralogs for NECTIN4 Gene

genes like me logo Genes that share paralogs with NECTIN4: view

Variants for NECTIN4 Gene

Sequence variations from dbSNP and Humsavar for NECTIN4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs267606992 Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1) [MIM:613573], Pathogenic 161,077,629(-) GGACA(C/T)GGAGG reference, missense
rs267606991 Pathogenic 161,076,355(-) GACAC(A/G)GTAAG reference, missense
rs387907014 Pathogenic 161,077,548(-) GGTGC(C/G)TAGCC reference, missense
rs730880260 Pathogenic 161,074,705(-) GGCTT(-/T)CCCCC reference, frameshift-variant
rs10159127 -- 161,086,828(+) GCCAG(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NECTIN4 Gene

Variant ID Type Subtype PubMed ID
esv3351730 CNV duplication 20981092
esv988172 CNV deletion 20482838
nsv1161729 CNV duplication 26073780
nsv3221 CNV deletion 18451855

Variation tolerance for NECTIN4 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.40; 63.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NECTIN4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NECTIN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECTIN4 Gene

Disorders for NECTIN4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NECTIN4 Gene - From: ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ectodermal dysplasia-syndactyly syndrome 1
  • ectodermal dysplasia-syndactyly syndrome
measles
  • morbilli
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NECT4_HUMAN
  • Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1) [MIM:613573]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg-shaped and conical crowns. Patients have normal sweating. {ECO:0000269 PubMed:20691405}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NECTIN4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NECTIN4
genes like me logo Genes that share disorders with NECTIN4: view

No data available for Genatlas for NECTIN4 Gene

Publications for NECTIN4 Gene

  1. Nectin-4 is a new histological and serological tumor associated marker for breast cancer. (PMID: 17474988) Fabre-Lafay S. … Lopez M. (BMC Cancer 2007) 3 4 22 64
  2. Nectin-4, a new serological breast cancer marker, is a substrate for tumor necrosis factor-alpha-converting enzyme (TACE)/ADAM-17. (PMID: 15784625) Fabre-Lafay S. … Lopez M. (J. Biol. Chem. 2005) 3 4 22 64
  3. Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction. (PMID: 11544254) Reymond N. … Lopez M. (J. Biol. Chem. 2001) 2 3 4 64
  4. Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. (PMID: 23202587) Zhang X. … Gao G.F. (Nat. Struct. Mol. Biol. 2013) 3 4 64
  5. Adherens junction protein nectin-4 is the epithelial receptor for measles virus. (PMID: 22048310) Muhlebach M.D. … Cattaneo R. (Nature 2011) 3 4 64

Products for NECTIN4 Gene

Sources for NECTIN4 Gene

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