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Aliases for NECTIN3 Gene

Aliases for NECTIN3 Gene

  • Nectin Cell Adhesion Molecule 3 2 3
  • Poliovirus Receptor-Related 3 2 3 5
  • PVRL3 3 4 5
  • Poliovirus Receptor-Related Protein 3 3 4
  • CDW113 3 4
  • PRR3 3 4
  • CD113 Antigen 4
  • Nectin 3 3
  • NECTIN-3 3
  • CD113 3
  • PVRR3 3
  • PPR3 3

External Ids for NECTIN3 Gene

Previous HGNC Symbols for NECTIN3 Gene

  • PVRL3

Summaries for NECTIN3 Gene

Entrez Gene Summary for NECTIN3 Gene

  • This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for NECTIN3 Gene

NECTIN3 (Nectin Cell Adhesion Molecule 3) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Adherens junction. An important paralog of this gene is NECTIN2.

UniProtKB/Swiss-Prot for NECTIN3 Gene

  • Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Gene Wiki entry for NECTIN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECTIN3 Gene

Genomics for NECTIN3 Gene

Regulatory Elements for NECTIN3 Gene

Promoters for NECTIN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NECTIN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NECTIN3 Gene

Chromosome:
3
Start:
111,070,071 bp from pter
End:
111,275,563 bp from pter
Size:
205,493 bases
Orientation:
Plus strand

Genomic View for NECTIN3 Gene

Genes around NECTIN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECTIN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECTIN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECTIN3 Gene

Proteins for NECTIN3 Gene

  • Protein details for NECTIN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQS3-PVRL3_HUMAN
    Recommended name:
    Nectin-3
    Protein Accession:
    Q9NQS3
    Secondary Accessions:
    • E9PFR0
    • Q6NVZ3
    • Q8NC05
    • Q8WVU4
    • Q9BVA9
    • Q9Y412

    Protein attributes for NECTIN3 Gene

    Size:
    549 amino acids
    Molecular mass:
    61002 Da
    Quaternary structure:
    • Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between PVRL1 and PVRL3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with MLLT4/afadin, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT.
    SequenceCaution:
    • Sequence=AAH17572.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NECTIN3 Gene

    Alternative splice isoforms for NECTIN3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NECTIN3 Gene

Proteomics data for NECTIN3 Gene at MOPED

Post-translational modifications for NECTIN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for NECTIN3

No data available for DME Specific Peptides for NECTIN3 Gene

Domains & Families for NECTIN3 Gene

Protein Domains for NECTIN3 Gene

Suggested Antigen Peptide Sequences for NECTIN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQS3

UniProtKB/Swiss-Prot:

PVRL3_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the nectin family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with NECTIN3: view

Function for NECTIN3 Gene

Molecular function for NECTIN3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Gene Ontology (GO) - Molecular Function for NECTIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IBA --
genes like me logo Genes that share ontologies with NECTIN3: view
genes like me logo Genes that share phenotypes with NECTIN3: view

Animal Models for NECTIN3 Gene

MGI Knock Outs for NECTIN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for NECTIN3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NECTIN3 Gene

Localization for NECTIN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECTIN3 Gene

Cell membrane; Single-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane.

Gene Ontology (GO) - Cellular Components for NECTIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005911 cell-cell junction IEA --
GO:0005913 cell-cell adherens junction IBA --
genes like me logo Genes that share ontologies with NECTIN3: view

No data available for Subcellular locations from COMPARTMENTS for NECTIN3 Gene

Pathways & Interactions for NECTIN3 Gene

genes like me logo Genes that share pathways with NECTIN3: view

Gene Ontology (GO) - Biological Process for NECTIN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002089 lens morphogenesis in camera-type eye IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules ISS --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0034332 adherens junction organization TAS --
genes like me logo Genes that share ontologies with NECTIN3: view

No data available for SIGNOR curated interactions for NECTIN3 Gene

Drugs & Compounds for NECTIN3 Gene

No Compound Related Data Available

Transcripts for NECTIN3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NECTIN3 Gene

No ASD Table

Relevant External Links for NECTIN3 Gene

GeneLoc Exon Structure for
NECTIN3
ECgene alternative splicing isoforms for
NECTIN3

Expression for NECTIN3 Gene

mRNA Expression by UniProt/SwissProt for NECTIN3 Gene

Q9NQS3-PVRL3_HUMAN
Tissue specificity: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NECTIN3 Gene

Orthologs for NECTIN3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECTIN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PVRL3 35
  • 92.25 (n)
  • 93.86 (a)
PVRL3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PVRL3 35
  • 93.84 (n)
  • 95.65 (a)
PVRL3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pvrl3 35
  • 87.78 (n)
  • 88.91 (a)
Nectin3 16
Pvrl3 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pvrl3 35
  • 87.18 (n)
  • 89.74 (a)
oppossum
(Monodelphis domestica)
Mammalia PVRL3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PVRL3 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PVRL3 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves PVRL3 35
  • 73.54 (n)
  • 70 (a)
PVRL3 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PVRL3 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12547 35
zebrafish
(Danio rerio)
Actinopterygii PVRL3 (2 of 2) 36
  • 38 (a)
OneToMany
pvrl3b 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for NECTIN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECTIN3 Gene

ENSEMBL:
Gene Tree for NECTIN3 (if available)
TreeFam:
Gene Tree for NECTIN3 (if available)

Paralogs for NECTIN3 Gene

Paralogs for NECTIN3 Gene

genes like me logo Genes that share paralogs with NECTIN3: view

Variants for NECTIN3 Gene

Sequence variations from dbSNP and Humsavar for NECTIN3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1370 -- 111,135,227(+) TTAGA(C/G)TAAAC intron-variant, utr-variant-3-prime
rs11202 -- 111,136,452(-) TTTGC(A/C)AAATG intron-variant, utr-variant-3-prime
rs15611 -- 111,133,860(-) ACGTC(A/C/G/T)GTCTT intron-variant, nc-transcript-variant, reference, missense, utr-variant-3-prime
rs717160 -- 111,092,704(+) tttta(A/G)tcact intron-variant
rs1128755 -- 111,200,693(+) GCTCT(G/T)AACTT intron-variant

Variation tolerance for NECTIN3 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NECTIN3 Gene

HapMap Linkage Disequilibrium report
NECTIN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NECTIN3 Gene

Disorders for NECTIN3 Gene

Relevant External Links for NECTIN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NECTIN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NECTIN3

No disorders were found for NECTIN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NECTIN3 Gene

Publications for NECTIN3 Gene

  1. Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. (PMID: 11024295) Reymond N. … Lopez M. (Gene 2000) 2 3 4 67
  2. Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. (PMID: 10744716) Satoh-Horikawa K. … Takai Y. (J. Biol. Chem. 2000) 3 23
  3. Identification of an epithelial cell receptor responsible for Clostridium difficile TcdB-induced cytotoxicity. (PMID: 26038560) LaFrance M.E. … Lacy D.B. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for NECTIN3 Gene

Sources for NECTIN3 Gene

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