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Aliases for NECTIN2 Gene

Aliases for NECTIN2 Gene

  • Nectin Cell Adhesion Molecule 2 2 3
  • Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) 2 3 5
  • PVRL2 3 4 5
  • HVEB 3 4
  • PRR2 3 4
  • Poliovirus Receptor-Related Protein 2 4
  • Herpes Virus Entry Mediator B 4
  • Herpesvirus Entry Mediator B 4
  • Herpesvirus Entry Protein B 3
  • Poliovirus Receptor-Like 2 3
  • CD112 Antigen 4
  • CD112 3
  • PVRR2 3

External Ids for NECTIN2 Gene

Previous HGNC Symbols for NECTIN2 Gene

  • HVEB
  • PVRL2

Summaries for NECTIN2 Gene

Entrez Gene Summary for NECTIN2 Gene

  • This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for NECTIN2 Gene

NECTIN2 (Nectin Cell Adhesion Molecule 2) is a Protein Coding gene. Diseases associated with NECTIN2 include herpes simplex and ovarian cystic teratoma. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Immune System. An important paralog of this gene is NECTIN3.

UniProtKB/Swiss-Prot for NECTIN2 Gene

  • Probable cell adhesion protein.

  • (Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Gene Wiki entry for NECTIN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECTIN2 Gene

Genomics for NECTIN2 Gene

Regulatory Elements for NECTIN2 Gene

Promoters for NECTIN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NECTIN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NECTIN2 Gene

Chromosome:
19
Start:
44,846,136 bp from pter
End:
44,889,228 bp from pter
Size:
43,093 bases
Orientation:
Plus strand

Genomic View for NECTIN2 Gene

Genes around NECTIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECTIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECTIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECTIN2 Gene

Proteins for NECTIN2 Gene

  • Protein details for NECTIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92692-PVRL2_HUMAN
    Recommended name:
    Nectin-2
    Protein Accession:
    Q92692
    Secondary Accessions:
    • A8K5L5
    • O75455
    • Q6IBI6
    • Q96J29

    Protein attributes for NECTIN2 Gene

    Size:
    538 amino acids
    Molecular mass:
    57742 Da
    Quaternary structure:
    • Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT.
    • (Microbial infection) Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D (PubMed:11602758, PubMed:9657005).

    Three dimensional structures from OCA and Proteopedia for NECTIN2 Gene

    Alternative splice isoforms for NECTIN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NECTIN2 Gene

Proteomics data for NECTIN2 Gene at MOPED

Post-translational modifications for NECTIN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NECTIN2 Gene

Antibody Products

  • R&D Systems Antibodies for NECTIN2 (Nectin-2/CD112)
  • Cloud-Clone Corp. Antibodies for NECTIN2

No data available for DME Specific Peptides for NECTIN2 Gene

Domains & Families for NECTIN2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92692

UniProtKB/Swiss-Prot:

PVRL2_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the nectin family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the nectin family.
genes like me logo Genes that share domains with NECTIN2: view

Function for NECTIN2 Gene

Molecular function for NECTIN2 Gene

UniProtKB/Swiss-Prot Function:
Probable cell adhesion protein.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).

Gene Ontology (GO) - Molecular Function for NECTIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with NECTIN2: view
genes like me logo Genes that share phenotypes with NECTIN2: view

Animal Models for NECTIN2 Gene

MGI Knock Outs for NECTIN2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NECTIN2

miRNA for NECTIN2 Gene

miRTarBase miRNAs that target NECTIN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NECTIN2 Gene

Localization for NECTIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECTIN2 Gene

Cell membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for NECTIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005913 cell-cell adherens junction IBA --
genes like me logo Genes that share ontologies with NECTIN2: view

No data available for Subcellular locations from COMPARTMENTS for NECTIN2 Gene

Pathways & Interactions for NECTIN2 Gene

genes like me logo Genes that share pathways with NECTIN2: view

Gene Ontology (GO) - Biological Process for NECTIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 12913096
GO:0002891 positive regulation of immunoglobulin mediated immune response IMP 16831868
GO:0007010 cytoskeleton organization IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA,IDA 9845526
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA --
genes like me logo Genes that share ontologies with NECTIN2: view

No data available for SIGNOR curated interactions for NECTIN2 Gene

Drugs & Compounds for NECTIN2 Gene

(2) Drugs for NECTIN2 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CMX001 Investigational Pharma Broad spectrum antiviral drug 0

(1) Additional Compounds for NECTIN2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NECTIN2: view

Transcripts for NECTIN2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for NECTIN2 Gene

No ASD Table

Relevant External Links for NECTIN2 Gene

GeneLoc Exon Structure for
NECTIN2
ECgene alternative splicing isoforms for
NECTIN2

Expression for NECTIN2 Gene

mRNA Expression by UniProt/SwissProt for NECTIN2 Gene

Q92692-PVRL2_HUMAN
Tissue specificity: Ubiquitous.

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NECTIN2 Gene

Orthologs for NECTIN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECTIN2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PVRL2 35
  • 82.78 (n)
  • 79.37 (a)
PRR2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pvrl2 35
  • 78.32 (n)
  • 75.61 (a)
Nectin2 16
Pvrl2 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PVRL2 35
  • 99.32 (n)
  • 99.26 (a)
PRR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pvrl2 35
  • 78.39 (n)
  • 75.43 (a)
cow
(Bos Taurus)
Mammalia PVRL2 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 54 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pvrl2l 36
  • 29 (a)
ManyToMany
si:ch73-22o12.1 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for NECTIN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECTIN2 Gene

ENSEMBL:
Gene Tree for NECTIN2 (if available)
TreeFam:
Gene Tree for NECTIN2 (if available)

Paralogs for NECTIN2 Gene

Paralogs for NECTIN2 Gene

Pseudogenes.org Pseudogenes for NECTIN2 Gene

genes like me logo Genes that share paralogs with NECTIN2: view

Variants for NECTIN2 Gene

Sequence variations from dbSNP and Humsavar for NECTIN2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs6857 -- 44,888,997(-) CCCTA(A/G)GCTGG utr-variant-3-prime
rs6859 -- 44,878,777(+) GGAAC(A/G)GCACA intron-variant, utr-variant-3-prime
rs365653 -- 44,858,389(-) CAACA(C/T)GGGCG intron-variant
rs440277 -- 44,857,967(+) gtatt(A/G)attgg intron-variant
rs369599 -- 44,876,079(-) GGGAG(A/G)GTTCC intron-variant

Variation tolerance for NECTIN2 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NECTIN2 Gene

HapMap Linkage Disequilibrium report
NECTIN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NECTIN2 Gene

Disorders for NECTIN2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NECTIN2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
herpes simplex
  • herpesvirus hominis disease
ovarian cystic teratoma
mature teratoma of the ovary
  • mature teratoma of ovary
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NECTIN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NECTIN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NECTIN2
genes like me logo Genes that share disorders with NECTIN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NECTIN2 Gene

Publications for NECTIN2 Gene

  1. The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene. (PMID: 7622062) Eberle F. … Lopez M. (Gene 1995) 2 3 4 23 67
  2. The murine homolog (Mph) of human herpesvirus entry protein B (HveB) mediates entry of pseudorabies virus but not herpes simplex virus types 1 and 2. (PMID: 10196354) Shukla D. … Spear P.G. (J. Virol. 1999) 2 3 23
  3. Crystallization and preliminary X-ray analysis of the V domain of human nectin-2. (PMID: 19478445) Qian X. … Yan J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009) 3 23
  4. Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. (PMID: 16831868) Bachelet I. … Levi-Schaffer F. (J. Biol. Chem. 2006) 3 23
  5. Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). (PMID: 15536144) Pende D. … Moretta L. (Blood 2005) 3 23

Products for NECTIN2 Gene

Sources for NECTIN2 Gene

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