Aliases for NECTIN1 Gene
- Nectin Cell Adhesion Molecule 1 2 3
- Poliovirus Receptor-Related 1 (Herpesvirus Entry Mediator C) 2 3 5
- PVRL1 3 4 5
- Poliovirus Receptor-Related Protein 1 3 4
- Herpes Virus Entry Mediator C 3 4
- Herpesvirus Ig-Like Receptor 3 4
- HVEC 3 4
- HIgR 3 4
- PRR1 3 4
- Ectodermal Dysplasia 4 (Margarita Island Type) 3
- Herpes Simplex Virus Type 1 Sensitivity 3
- Herpesvirus Entry Mediator C 4
- Poliovirus Receptor-Like 1 3
- CD111 Antigen 4
External Ids for NECTIN1 Gene
Previous HGNC Symbols for NECTIN1 Gene
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
GeneCards Summary for NECTIN1 Gene
NECTIN1 (Nectin Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with NECTIN1 include cleft lip/palate-ectodermal dysplasia syndrome and herpes simplex. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Adherens junction. An important paralog of this gene is NECTIN3.
UniProtKB/Swiss-Prot for NECTIN1 Gene
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Has some neurite outgrowth-promoting activity.
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.