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NECAP2 Gene

protein-coding   GIFtS: 50
GCID: GC01P016767

NECAP Endocytosis Associated 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NECAP Endocytosis Associated 21 2
NECAP-22 3
NECAP Endocytosis-Associated Protein 22 3
Adaptin Ear-Binding Coat-Associated Protein 22
Adaptin-Ear-Binding Coat-Associated Protein 22

External Ids:    HGNC: 255281   Entrez Gene: 557072   Ensembl: ENSG000001571917   OMIM: 6116245   UniProtKB: Q9NVZ33   

Export aliases for NECAP2 gene to outside databases

Previous GC identifers: GC01P016513 GC01P016639 GC01P015284


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NECAP2 Gene:
This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar
protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have
been described. (provided by RefSeq, Feb 2009)

GeneCards Summary for NECAP2 Gene:
NECAP2 (NECAP endocytosis associated 2) is a protein-coding gene. An important paralog of this gene is NECAP1.

UniProtKB/Swiss-Prot: NECP2_HUMAN, Q9NVZ3
Function: Involved in endocytosis (By similarity)

Gene Wiki entry for NECAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the NECAP2 gene promoter:
         SRF   AML1a   HTF   SRF (504 AA)   STAT1alpha   RORalpha2   POU2F1   POU2F1a   LyF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNECAP2 promoter sequence
   Search Chromatin IP Primers for NECAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NECAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

NECAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NECAP2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P016767:  view genomic region     (about GC identifiers)

Start:
16,767,167 bp from pter      End:
16,786,585 bp from pter
Size:
19,419 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NECP2_HUMAN, Q9NVZ3 (See protein sequence)
Recommended Name: Adaptin ear-binding coat-associated protein 2  
Size: 263 amino acids; 28339 Da
Subunit: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with
the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity)
Sequence caution: Sequence=BAB15758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DY19 E9PGQ8 Q5VSU4 Q5VSU5 Q9H7L1 Q9H8L1
Alternative splicing: 4 isoforms:  Q9NVZ3-1   Q9NVZ3-2   Q9NVZ3-3   Q9NVZ3-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NECAP2: NX_Q9NVZ3

Explore proteomics data for NECAP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NECAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001138749.1  NP_001138750.1  NP_060560.1  

    ENSEMBL proteins: 
     ENSP00000338746   ENSP00000424509   ENSP00000407091   ENSP00000391942   ENSP00000421867  
     ENSP00000427620   ENSP00000421335   ENSP00000423213   ENSP00000383925  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR012466 NECAP-1

    Graphical View of Domain Structure for InterPro Entry Q9NVZ3

    ProtoNet protein and cluster: Q9NVZ3

    1 Blocks protein domain: IPB012466 Protein of unknown function DUF1681

    UniProtKB/Swiss-Prot: NECP2_HUMAN, Q9NVZ3
    Domain: The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through
    hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is
    tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself
    (By similarity)
    Similarity: Belongs to the NECAP family


    Find genes that share domains with NECAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NECP2_HUMAN, Q9NVZ3
    Function: Involved in endocytosis (By similarity)

    Phenotypes:
         2 GenomeRNAi human phenotypes for NECAP2:

     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
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    hsa-mir-149-5p (MIRT045422), hsa-mir-124-3p (MIRT004907)

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    Selected qRT-PCR Assays for microRNAs that regulate NECAP2 (see all 9):
    hsa-miR-27a hsa-miR-124 hsa-miR-518a-5p hsa-miR-330-3p hsa-miR-506 hsa-miR-497* hsa-miR-27b hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidNECAP2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NECP2_HUMAN, Q9NVZ3: Cytoplasmic vesicle, clathrin-coated vesicle membrane (By similarity). Cell membrane (By
    similarity). Note=Colocalizes with AP-2 at the plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005886plasma membrane IEA--
    GO:0005905coated pit ISS--
    GO:0016020membrane ----
    GO:0030125clathrin vesicle coat ISS--

    Find genes that share ontologies with NECAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NECAP2
    Interactions:

        Search GeneGlobe Interaction Network for NECAP2

    Selected Interacting proteins for NECAP2 (Q9NVZ32, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP2B1P630102, 3MINT-67452 I2D: score=5 
    PLSCR1O151622, 3MINT-67190 I2D: score=5 
    TRAF2Q129333I2D: score=5 
    NMIQ132873I2D: score=4 
    AP1G1O437473I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis ISS--
    GO:0015031protein transport IEA--

    Find genes that share ontologies with NECAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NECAP2 (NECP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NECAP2 gene (3 alternative transcripts): 
    NM_001145277.1  NM_001145278.1  NM_018090.4  

    Unigene Cluster for NECAP2:

    NECAP endocytosis associated 2
    Hs.437385  [show with all ESTs]
    Unigene Representative Sequence: NM_018090
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337132(uc001ayo.3 uc010ocd.2 uc001ayq.3 uc021ogo.1)
    ENST00000504551 ENST00000457722 ENST00000486390 ENST00000443980 ENST00000504858
    ENST00000508680 ENST00000492095 ENST00000459640 ENST00000496239 ENST00000513161
    ENST00000509727 ENST00000406746
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NECAP2 (see all 9):
    hsa-miR-27a hsa-miR-124 hsa-miR-518a-5p hsa-miR-330-3p hsa-miR-506 hsa-miR-497* hsa-miR-27b hsa-miR-548c-3p
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      QuantiTect SYBR Green Assays in human, mouse, rat NECAP2
      QuantiFast Probe-based Assays in human, mouse, rat NECAP2

    Additional mRNA sequence: 

    AK001282.1 AK021938.1 AK023545.1 AK223344.1 AK300764.1 AK302227.1 BC017014.1 BC018914.2 

    19 DOTS entries:

    DT.100866337  DT.91751106  DT.100030072  DT.218377  DT.91713835  DT.100652109  DT.40107593  DT.95157983 
    DT.100869077  DT.409313  DT.95158002  DT.100640434  DT.100652108  DT.100866753  DT.121346660  DT.40308785 
    DT.91729007  DT.95157995  DT.95196312 

    Selected AceView cDNA sequences (see all 446):

    BG058491 AI952960 W95726 CR622734 AA731674 BG385473 BX384185 BX357736 
    AI281236 BQ000959 BX458346 BG337800 BC018914 AA872633 BP369832 AI753963 
    BQ923293 CK903004 AI956128 BM456664 AI871706 BM555821 AA722679 BI769058 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NECAP2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                          -                             -     -           -                           
    SP2:                          -                             -     -           -                           
    SP3:                          -                             -                 -                           
    SP4:                          -                             -     -           -     -                     
    SP5:                    -     -                             -     -                                       


    ECgene alternative splicing isoforms for NECAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NECAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCACAGTGC
    NECAP2 Expression
    About this image

    NECAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NECAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.437385
        Custom PCR Arrays for NECAP2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NECAP2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Necap21 , 5 NECAP endocytosis associated 21, 5 86.06(n)1
    89.35(a)1
      4 (73.35 cM)5
    661471  NM_025383.31  NP_079659.11 
     1410665125 
    chicken
    (Gallus gallus)
    Aves NECAP21 NECAP endocytosis associated 2 76.01(n)
    78.6(a)
      419464  NM_001012837.1  NP_001012855.1 
    lizard
    (Anolis carolinensis)
    Reptilia NECAP26
    NECAP endocytosis associated 2
    66(a)
    1 ↔ 1
    GL345048.1(208-3690)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41592 Xenopus laevis transcribed sequence with weak similarity to protein refNP_060560.1 (H.sapiens) hypothetical protein FLJ10420 [Homo sapiens] less 76.26(n)    CF520255.1 
    zebrafish
    (Danio rerio)
    Actinopterygii necap21 NECAP endocytosis associated 2 64.52(n)
    63.71(a)
      553536  NM_001243164.1  NP_001230093.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91326
    --
    51(a)
    1 → many
    X(16690931-16694741)
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y110A2AR.31 CELE_Y110A2AR.3 52.05(n)
    50.88(a)
      173638  NM_061997.5  NP_494398.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NAP41 NAP4 49.8(n)
    42.97(a)
      839378  NM_100270.3  NP_563693.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g04760001 Os10g0476000 50(n)
    46.77(a)
      4348887  NM_001071379.1  NP_001064844.1 


    ENSEMBL Gene Tree for NECAP2 (if available)
    TreeFam Gene Tree for NECAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NECAP2 gene
    NECAP12  
    1 SIMAP similar gene for NECAP2 using alignment to 5 protein entries:     NECP2_HUMAN (see all proteins):
    NECAP1

    Find genes that share paralogs with NECAP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NECAP2 (see all 480)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880768091,2
    --16766006(+) CCCGGA/GAGGTG 3 -- us2k10--------
    rs1807722521,2
    C--16766040(+) CACCAC/TTGCAC 3 -- us2k10--------
    rs1460884931,2
    --16766111(+) GAGAAG/TGAGAG 3 -- us2k10--------
    rs1865805421,2
    --16766344(+) TTCTTC/TTTTTT 3 -- us2k10--------
    rs1443242561,2
    --16766488(+) CACACA/GCCACC 3 -- us2k10--------
    rs726380431,2
    C,F--16766769(+) GGTAGG/AGTAAT 3 -- us2k11Minor allele frequency- A:0.04NA 120
    rs577539741,2
    C,F--16766868(+) AAAGGC/GTGGAG 3 -- us2k14Minor allele frequency- G:0.05WA NA EA 360
    rs1909808701,2
    C--16766970(+) CCAGAC/TCACGG 3 -- us2k10--------
    rs1821741701,2
    --16766995(+) TGTCCA/CTGGCG 3 -- us2k10--------
    rs788733061,2
    C--16767030(+) GGAGGG/ATGTCT 3 -- us2k12Minor allele frequency- A:0.10CSA WA 120

    HapMap Linkage Disequilibrium report for NECAP2 (16767167 - 16786585 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NECAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1n68CNV Loss17160897
    nsv9213CNV Loss18304495
    nsv428421CNV Gain+Loss18775914
    dgv29e1CNV Complex17122850
    dgv28e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611624    OMIM disorders: --


    Find genes that share disorders with NECAP2           About GenesLikeMe


    Export disorders for NECAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NECAP2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with NECAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. (PubMed id 14555962)1, 3 Ritter B....McPherson P.S. (EMBO Rep. 2003)
    5. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (DNA Res. 2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. (PubMed id 19738201)1 Humphries J.D....Humphries M.J. (Sci Signal 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55707 HGNC: 25528 AceView: FLJ10420 Ensembl:ENSG00000157191 euGenes: HUgn55707
    ECgene: NECAP2 H-InvDB: NECAP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NECAP2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NECAP2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NECAP2 gene:
    Search GeneIP for patents involving NECAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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