Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NECAP2 Gene

Aliases for NECAP2 Gene

  • NECAP Endocytosis Associated 2 2 3 5
  • NECAP Endocytosis-Associated Protein 2 3 4
  • NECAP-2 3 4
  • Adaptin-Ear-Binding Coat-Associated Protein 2 3

External Ids for NECAP2 Gene

Previous GeneCards Identifiers for NECAP2 Gene

  • GC01P016513
  • GC01P016639
  • GC01P016767
  • GC01P015284

Summaries for NECAP2 Gene

Entrez Gene Summary for NECAP2 Gene

  • This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for NECAP2 Gene

NECAP2 (NECAP Endocytosis Associated 2) is a Protein Coding gene. An important paralog of this gene is NECAP1.

UniProtKB/Swiss-Prot for NECAP2 Gene

  • Involved in endocytosis.

Gene Wiki entry for NECAP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAP2 Gene

Genomics for NECAP2 Gene

Regulatory Elements for NECAP2 Gene

Enhancers for NECAP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NECAP2 on UCSC Golden Path with GeneCards custom track

Promoters for NECAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NECAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NECAP2 Gene

16,440,672 bp from pter
16,460,090 bp from pter
19,419 bases
Plus strand

Genomic View for NECAP2 Gene

Genes around NECAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECAP2 Gene

Proteins for NECAP2 Gene

  • Protein details for NECAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adaptin ear-binding coat-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • B4DY19
    • E9PGQ8
    • Q5VSU4
    • Q5VSU5
    • Q9H7L1
    • Q9H8L1

    Protein attributes for NECAP2 Gene

    263 amino acids
    Molecular mass:
    28339 Da
    Quaternary structure:
    • Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity).
    • Sequence=BAB15758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NECAP2 Gene


neXtProt entry for NECAP2 Gene

Proteomics data for NECAP2 Gene at MOPED

Post-translational modifications for NECAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NECAP2 Gene

Domains & Families for NECAP2 Gene

Protein Domains for NECAP2 Gene

Suggested Antigen Peptide Sequences for NECAP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).
  • Belongs to the NECAP family.
  • The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).
  • Belongs to the NECAP family.
genes like me logo Genes that share domains with NECAP2: view

No data available for Gene Families for NECAP2 Gene

Function for NECAP2 Gene

Molecular function for NECAP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in endocytosis.
genes like me logo Genes that share phenotypes with NECAP2: view

Animal Model Products

miRNA for NECAP2 Gene

miRTarBase miRNAs that target NECAP2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NECAP2 Gene

Localization for NECAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECAP2 Gene

Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell membrane. Note=Colocalizes with AP-2 at the plasma membrane. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for NECAP2 Gene COMPARTMENTS Subcellular localization image for NECAP2 gene
Compartment Confidence
plasma membrane 3
cytosol 2
nucleus 2
cytoskeleton 1
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NECAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030125 clathrin vesicle coat ISS --
genes like me logo Genes that share ontologies with NECAP2: view

Pathways & Interactions for NECAP2 Gene

SuperPathways for NECAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NECAP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NECAP2 Gene

Drugs & Compounds for NECAP2 Gene

No Compound Related Data Available

Transcripts for NECAP2 Gene

Unigene Clusters for NECAP2 Gene

NECAP endocytosis associated 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NECAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -

Relevant External Links for NECAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NECAP2 Gene

mRNA expression in normal human tissues for NECAP2 Gene

Protein differential expression in normal tissues from HIPED for NECAP2 Gene

This gene is overexpressed in Lymph node (11.7) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NECAP2 Gene

SOURCE GeneReport for Unigene cluster for NECAP2 Gene Hs.437385

genes like me logo Genes that share expression patterns with NECAP2: view

Protein tissue co-expression partners for NECAP2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NECAP2 Gene

Orthologs for NECAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NECAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NECAP2 35
  • 89.73 (n)
  • 91.25 (a)
  • 79 (a)
(Canis familiaris)
Mammalia NECAP2 35
  • 91.63 (n)
  • 93.16 (a)
  • 79 (a)
(Mus musculus)
Mammalia Necap2 35
  • 86.06 (n)
  • 89.35 (a)
Necap2 16
Necap2 36
  • 78 (a)
(Pan troglodytes)
Mammalia NECAP2 35
  • 99.11 (n)
  • 98.86 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Necap2 35
  • 85.61 (n)
  • 90 (a)
(Monodelphis domestica)
Mammalia NECAP2 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia NECAP2 36
  • 81 (a)
(Gallus gallus)
Aves NECAP2 35
  • 76.01 (n)
  • 78.6 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia NECAP2 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia necap2 35
  • 71.81 (n)
  • 72.2 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4159 35
(Danio rerio)
Actinopterygii necap2 35
  • 64.52 (n)
  • 63.71 (a)
necap2 36
  • 58 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13473 35
fruit fly
(Drosophila melanogaster)
Insecta CG9132 36
  • 51 (a)
(Caenorhabditis elegans)
Secernentea CELE_Y110A2AR.3 35
  • 52.05 (n)
  • 50.88 (a)
Y110A2AR.3 36
  • 48 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NAP4 35
  • 49.8 (n)
  • 42.97 (a)
(Oryza sativa)
Liliopsida Os10g0476000 35
  • 50 (n)
  • 46.77 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04345 35
  • 48.18 (n)
  • 38.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2050 36
  • 51 (a)
Species with no ortholog for NECAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NECAP2 Gene

Gene Tree for NECAP2 (if available)
Gene Tree for NECAP2 (if available)

Paralogs for NECAP2 Gene

Paralogs for NECAP2 Gene

(1) SIMAP similar genes for NECAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NECAP2: view

Variants for NECAP2 Gene

Sequence variations from dbSNP and Humsavar for NECAP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs35056694 - 16,449,158(+) ACTGG(A/C)CCTGG reference, missense
rs15137 -- 16,459,952(-) ATAAA(A/T)GGAAT utr-variant-3-prime
rs166785 -- 16,452,903(-) TTAGG(A/G)ATCAG intron-variant
rs279015 -- 16,452,704(+) AAGCG(A/G)GTGTC intron-variant
rs279017 -- 16,454,531(+) ttgta(A/T)tttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NECAP2 Gene

Variant ID Type Subtype PubMed ID
dgv28e1 CNV Complex 17122850
dgv29e1 CNV Complex 17122850
nsv428421 CNV Gain+Loss 18775914
dgv1n68 CNV Loss 17160897
nsv9213 CNV Loss 18304495

Variation tolerance for NECAP2 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NECAP2 Gene

Disorders for NECAP2 Gene

Relevant External Links for NECAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NECAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NECAP2 Gene

Publications for NECAP2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. (PMID: 14555962) Ritter B. … McPherson P.S. (EMBO Rep. 2003) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3

Products for NECAP2 Gene

Sources for NECAP2 Gene