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Aliases for NECAP2 Gene

Aliases for NECAP2 Gene

  • NECAP Endocytosis Associated 2 2 3 5
  • NECAP Endocytosis-Associated Protein 2 4
  • NECAP-2 4

External Ids for NECAP2 Gene

Previous GeneCards Identifiers for NECAP2 Gene

  • GC01P016513
  • GC01P016639
  • GC01P016767
  • GC01P015284

Summaries for NECAP2 Gene

Entrez Gene Summary for NECAP2 Gene

  • This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]

GeneCards Summary for NECAP2 Gene

NECAP2 (NECAP Endocytosis Associated 2) is a Protein Coding gene. Diseases associated with NECAP2 include Cataract 8, Multiple Types. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. An important paralog of this gene is NECAP1.

UniProtKB/Swiss-Prot for NECAP2 Gene

  • Involved in endocytosis.

Gene Wiki entry for NECAP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAP2 Gene

Genomics for NECAP2 Gene

Regulatory Elements for NECAP2 Gene

Enhancers for NECAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G016498 1.6 FANTOM5 ENCODE dbSUPER 17 +58.4 58399 2.0 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF121 GTF3C2 GLIS2 ZNF143 ENSG00000237938 NECAP2 CROCCP3 SPATA21 SPEN ENSG00000224621 RPS16P1 DDI2 RCC2 FAM131C
GH01G016440 1.2 ENCODE 14.2 +2.0 1968 5.2 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 MCM3 SP3 LINC01772 NBPF1 LOC100421279 NECAP2 SPEN ENSG00000237938 RPS16P1 CROCCP2 RPL22P3 MFAP2
GH01G016384 1.3 Ensembl ENCODE dbSUPER 11.6 -54.3 -54264 4.7 WRNIP1 SIN3A ASH2L ZNF195 EBF1 ZIC2 ZBTB40 GLIS2 POLR2A SCRT2 ARHGEF19 SPATA21 NECAP2 FBXO42 GC01P016389 RPL22P3
GH01G016391 1.1 Ensembl dbSUPER 11.9 -48.9 -48872 0.8 HDAC1 PKNOX1 TCF12 EGR1 EGR2 HDAC8 NFIC RAD51 SMARCA4 ZNF658 NECAP2 SPATA21 GC01P016389 PIR56124
GH01G016363 1.1 Ensembl ENCODE 10.9 -77.2 -77172 0.6 RB1 ARNT ARID4B FEZF1 ZNF2 RAD21 RFX5 ZNF143 CREM MIXL1 ARHGEF19 ARHGEF19-AS1 SPATA21 NECAP2 RPL22P3 SZRD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NECAP2 on UCSC Golden Path with GeneCards custom track

Promoters for NECAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002064 428 1401 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC

Genomic Location for NECAP2 Gene

Chromosome:
1
Start:
16,440,672 bp from pter
End:
16,460,090 bp from pter
Size:
19,419 bases
Orientation:
Plus strand

Genomic View for NECAP2 Gene

Genes around NECAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECAP2 Gene

Proteins for NECAP2 Gene

  • Protein details for NECAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVZ3-NECP2_HUMAN
    Recommended name:
    Adaptin ear-binding coat-associated protein 2
    Protein Accession:
    Q9NVZ3
    Secondary Accessions:
    • B4DY19
    • E9PGQ8
    • Q5VSU4
    • Q5VSU5
    • Q9H7L1
    • Q9H8L1

    Protein attributes for NECAP2 Gene

    Size:
    263 amino acids
    Molecular mass:
    28339 Da
    Quaternary structure:
    • Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity).
    SequenceCaution:
    • Sequence=BAB15758.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NECAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NECAP2 Gene

Post-translational modifications for NECAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for NECAP2

No data available for DME Specific Peptides for NECAP2 Gene

Domains & Families for NECAP2 Gene

Protein Domains for NECAP2 Gene

Suggested Antigen Peptide Sequences for NECAP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVZ3

UniProtKB/Swiss-Prot:

NECP2_HUMAN :
  • The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).
  • Belongs to the NECAP family.
Domain:
  • The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself (By similarity).
Family:
  • Belongs to the NECAP family.
genes like me logo Genes that share domains with NECAP2: view

No data available for Gene Families for NECAP2 Gene

Function for NECAP2 Gene

Molecular function for NECAP2 Gene

UniProtKB/Swiss-Prot Function:
Involved in endocytosis.
genes like me logo Genes that share phenotypes with NECAP2: view

Animal Model Products

CRISPR Products

miRNA for NECAP2 Gene

miRTarBase miRNAs that target NECAP2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NECAP2 Gene

Localization for NECAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECAP2 Gene

Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell membrane. Note=Colocalizes with AP-2 at the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NECAP2 gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1
endosome 1

Gene Ontology (GO) - Cellular Components for NECAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005886 plasma membrane IEA --
GO:0005905 clathrin-coated pit ISS --
GO:0016020 membrane IEA --
GO:0030125 clathrin vesicle coat ISS --
genes like me logo Genes that share ontologies with NECAP2: view

Pathways & Interactions for NECAP2 Gene

genes like me logo Genes that share pathways with NECAP2: view

Gene Ontology (GO) - Biological Process for NECAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006897 endocytosis IEA,ISS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with NECAP2: view

No data available for SIGNOR curated interactions for NECAP2 Gene

Drugs & Compounds for NECAP2 Gene

No Compound Related Data Available

Transcripts for NECAP2 Gene

Unigene Clusters for NECAP2 Gene

NECAP endocytosis associated 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NECAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: -
SP7:
SP8:

Relevant External Links for NECAP2 Gene

GeneLoc Exon Structure for
NECAP2
ECgene alternative splicing isoforms for
NECAP2

Expression for NECAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NECAP2 Gene

Protein differential expression in normal tissues from HIPED for NECAP2 Gene

This gene is overexpressed in Lymph node (11.7) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NECAP2 Gene



Protein tissue co-expression partners for NECAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NECAP2 Gene:

NECAP2

SOURCE GeneReport for Unigene cluster for NECAP2 Gene:

Hs.437385

Evidence on tissue expression from TISSUES for NECAP2 Gene

  • Intestine(4.4)
  • Liver(4.3)
  • Spleen(4.3)
  • Eye(4.1)
  • Nervous system(3.6)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with NECAP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NECAP2 Gene

Orthologs for NECAP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NECAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NECAP2 34 35
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia NECAP2 34 35
  • 91.63 (n)
cow
(Bos Taurus)
Mammalia NECAP2 34 35
  • 89.73 (n)
mouse
(Mus musculus)
Mammalia Necap2 34 16 35
  • 86.06 (n)
rat
(Rattus norvegicus)
Mammalia Necap2 34
  • 85.61 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NECAP2 35
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NECAP2 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NECAP2 34 35
  • 76.01 (n)
lizard
(Anolis carolinensis)
Reptilia NECAP2 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia necap2 34
  • 71.81 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4159 34
zebrafish
(Danio rerio)
Actinopterygii necap2 34 35
  • 64.52 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13473 34
fruit fly
(Drosophila melanogaster)
Insecta CG9132 35
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y110A2AR.3 34
  • 52.05 (n)
Y110A2AR.3 35
  • 48 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NAP4 34
  • 49.8 (n)
rice
(Oryza sativa)
Liliopsida Os10g0476000 34
  • 50 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2050 35
  • 51 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04345 34
  • 48.18 (n)
Species where no ortholog for NECAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NECAP2 Gene

ENSEMBL:
Gene Tree for NECAP2 (if available)
TreeFam:
Gene Tree for NECAP2 (if available)

Paralogs for NECAP2 Gene

Paralogs for NECAP2 Gene

(1) SIMAP similar genes for NECAP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NECAP2: view

Variants for NECAP2 Gene

Sequence variations from dbSNP and Humsavar for NECAP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193921123 Uncertain significance 16,449,174(+) AAGGA(G/T)GGCCA nc-transcript-variant, reference, missense
rs1000033591 -- 16,450,199(+) TCTCG(C/T)TTGGA intron-variant, nc-transcript-variant
rs1000147663 -- 16,457,761(+) AGGCT(A/G)GAGTG intron-variant
rs1000164239 -- 16,457,514(+) TTCCT(C/G)TTTGC intron-variant
rs1000181434 -- 16,440,369(+) AGGCA(A/G)AGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NECAP2 Gene

Variant ID Type Subtype PubMed ID
dgv1n68 CNV loss 17160897
dgv39n100 CNV gain 25217958
esv2758925 CNV gain+loss 17122850
nsv428421 CNV gain+loss 18775914
nsv9213 CNV loss 18304495

Variation tolerance for NECAP2 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NECAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NECAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECAP2 Gene

Disorders for NECAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NECAP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 8, multiple types
  • cataract 8 multiple types
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NECAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NECAP2
genes like me logo Genes that share disorders with NECAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NECAP2 Gene

Publications for NECAP2 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. (PMID: 14555962) Ritter B. … McPherson P.S. (EMBO Rep. 2003) 2 3 64
  5. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3 4 64

Products for NECAP2 Gene

Sources for NECAP2 Gene

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