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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NECAP1 Gene

protein-coding GIFtS: 53
GCID: GC12P007926

NECAP endocytosis associated 1

Explore 3 diseases affiliated with
NECAP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
NECAP Endocytosis Associated 1¹ ²
NECAP-1² ³
NECAP Endocytosis-Associated Protein 1² ³
DKFZP566B183¹
Adaptin Ear-Binding Coat-Associated Protein 1²
Adaptin-Ear-Binding Coat-Associated Protein 1²

External Ids:	HGNC: 24539¹	Entrez Gene: 25977²	Ensembl: ENSG00000089818⁷	OMIM: 611623⁵	UniProtKB: Q8NC96³

Export aliases for NECAP1 gene to outside databases

Previous GC identifers: GC12P008110 GC12P007758 GC12P007989 GC12P008234 GC12P008046

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96

Function: Involved in endocytosis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009714.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NECAP1 gene promoter:
Bach1 Elk-1 AML1a Pbx1a Pax-2 Pax-2a AP-2gamma FOXO4 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NECAP1 promoter sequence

Search SABiosciences Chromatin IP Primers for NECAP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NECAP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

NECAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NECAP1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P007926: view genomic region (about GC identifiers)

Start:	7,926,148 bp from pter	End:	8,250,373 bp from pter
Size:	324,226 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96 (See protein sequence)

Recommended Name: Adaptin ear-binding coat-associated protein 1

Size: 275 amino acids; 29737 Da

Subunit: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the

GAE domain proteins GGA1, GGA2 and GGA3 (By similarity)

Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane (By similarity). Cell membrane (By

similarity). Note=Colocalizes with AP-2 at the plasma membrane (By similarity)

Sequence caution: Sequence=AAH02888.1; Type=Erroneous initiation;

Secondary accessions: Q2NL73 Q5XG95 Q6NWY6 Q8N153 Q8NCB0 Q9BU52 Q9Y407

Alternative splicing: 2 isoforms: Q8NC96-1 Q8NC96-2

Explore the universe of human proteins at neXtProt for NECAP1: NX_Q8NC96

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NC96

NECAP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056324.2

ENSEMBL proteins:

ENSP00000341737 ENSP00000401963 ENSP00000440658 ENSP00000439319 ENSP00000446076

ENSP00000437448

Reactome Protein details: Q8NC96
Human Recombinant Protein Products:

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	Uscn Proteins for NECAP1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005905	coated pit	IEA	--
GO:0016020	membrane	--	--
GO:0030125	clathrin vesicle coat	IEA	--
GO:0030665	clathrin-coated vesicle membrane	--	--

NECAP1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NECAP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NECAP1 for domains About GeneDecksing

2 InterPro domains/families:

IPR012466 NECAP-1

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q8NC96

ProtoNet protein and cluster: Q8NC96

1 Blocks protein family: IPB012466 Protein of unknown function DUF1681

UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96

Domain: The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through

hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by

the acidic context surrounding the motif and the properties of the second residue of the motif itself. The WXXF motif

1, which is preceded by an acidic residue and has a glycine in second position mediates specific interaction with

AP-1. The WXXF motif 2, which is followed by the C-terminal carboxyl group negative charge, allows specific

interaction with AP-2 (By similarity)

Similarity: Belongs to the NECAP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96

Function: Involved in endocytosis (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: NECAP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NECAP1
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate NECAP1 (see all 49):
		hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-25 hsa-miR-1245 hsa-miR-30d hsa-miR-105

		SwitchGear 3'UTR luciferase reporter plasmid: NECAP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: NECAP1 (NM_015509)
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		Search LifeMap BioReagents cell lines for NECAP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAP1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

NECAP1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NECAP1:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Clathrin derived vesicle budding

	trans-Golgi Network Vesicle Budding	1.00			Golgi Associated Vesicle Biogenesis	0.89
	Clathrin derived vesicle budding	1.00

Membrane Trafficking

Membrane Trafficking

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for NECAP1

	Membrane Trafficking
	Clathrin derived vesicle budding
	Golgi Associated Vesicle Biogenesis
	trans-Golgi Network Vesicle Budding

NECAP1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NECAP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/63 Interacting proteins for NECAP1 (Q8NC96³ ENSP00000341737⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 63)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DAB2	P98082³, ENSP00000313391⁴	I2D: score=2 STRING: ENSP00000313391
AP2M1	Q96CW1³, ENSP00000292807⁴	I2D: score=1 STRING: ENSP00000292807
AMPH	P49418³, ENSP00000348602⁴	I2D: score=1 STRING: ENSP00000348602
AP1G1	O43747³, ENSP00000377148⁴	I2D: score=1 STRING: ENSP00000377148
HIP1	O00291³, ENSP00000336747⁴	I2D: score=1 STRING: ENSP00000336747

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	IEA	--
GO:0015031	protein transport	IEA	--

NECAP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NECAP1
Search CenterWatch for drugs/clinical trials and news about NECAP1 / NECP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NECAP1 gene:

NM_015509.3

Unigene Cluster for NECAP1:

NECAP endocytosis associated 1

Hs.555927 [show with all ESTs]

Unigene Representative Sequence: AK094805

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000339754(uc001qtx.2 uc001qty.2) ENST00000546181 ENST00000542095

ENST00000545807 ENST00000450991 ENST00000544891 ENST00000541948 ENST00000540083

ENST00000537796 ENST00000545179 ENST00000540291

miRNA Products:		OriGene 3'-UTR Clone: NECAP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NECAP1
		8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate NECAP1 (see all 49):
		hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-25 hsa-miR-1245 hsa-miR-30d hsa-miR-105

		SwitchGear 3'UTR luciferase reporter plasmid: NECAP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NECAP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NECAP1

Additional cDNA sequence:

AK074858.1 AK074880.1 AK074923.1 AK075013.1 AK094805.1 AK290537.1 AK303675.1 AK314424.1

BC002888.2 BC067367.1 BC084551.1 BC110876.1 NR_024260.1

13 DOTS entries:

DT.444700 DT.100819919 DT.100819926 DT.121195735 DT.99966761 DT.121195718 DT.100740210 DT.99963654

DT.100683552 DT.95203526 DT.121195703 DT.91968296 DT.95203494

24/237 AceView cDNA sequences (see all 237):

BM477173 AA863072 AI435371 AA133161 AK074923 BQ183325 CA425092 BM728860

AI004112 BC002888 BM546167 BX110184 F12883 AA688259 AK074858 BC067367

F10486 BI791447 AW169556 BM479330 AA666244 BQ438163 BQ004390 CR622227

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NECAP1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:													-		-						-		-
SP2:													-		-
SP3:
SP4:													-		-
SP5:

ECgene alternative splicing isoforms for NECAP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NECAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTGTTCTT

About this image
See NECAP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NECAP1

SOURCE GeneReport for Unigene cluster: Hs.555927

SABiosciences Custom PCR Arrays for NECAP1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NECAP1 gene from 9/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Necap1^{1 , 5}	NECAP endocytosis associated 1^{1, 5}	89.7(n)¹ 94.18(a)¹		6 (57.96 cM)⁵ 67602¹ NM_026267.2¹ NP_080543.2¹ 122874557⁵
chicken (Gallus gallus)	Aves	NECAP1¹	NECAP endocytosis associated 1	76.3(n) 81.85(a)		770083 XM_003640439.1 XP_003640487.1
lizard (Anolis carolinensis)	Reptilia	NECAP1⁶	--	78(a)	1 ↔ 1	GL343236.1(1163397-1186287)
African clawed frog (Xenopus laevis)	Amphibia	BC054244.1²	--	76.97(n)		BC054244.1
zebrafish (Danio rerio)	Actinopterygii	zgc73124²	hypothetical protein MGC73124	75.37(n)		393695 BC059487.1
fruit fly (Drosophila melanogaster)	Insecta	CG9132¹	CG9132	56.05(n) 54.69(a)		2768881 NM_206767.2 NP_996490.1
worm (Caenorhabditis elegans)	Secernentea	Y110A2AR.3⁶	Protein Y110A2AR.3, isoform a	46(a)	1 → many	II(2913715-2919318)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATNAP4⁶ AT3G58600⁶	non-intrinsic ABC protein 4 Adaptin ear-binding coat-associated protein 1 NECA...	32(a) 25(a)	many ↔ many many ↔ many	1(991139-993118) 3(21668515-21671167)
rice (Oryza sativa)	Liliopsida	-- --	adaptin ear-binding coat-associated protein 2, put... adaptin ear-binding coat-associated protein 2, put...	33(a) 27(a)	many ↔ many many ↔ many	10(17655206-17658332) 1(24374833-24378885)

ENSEMBL Gene Tree for NECAP1 (if available)
TreeFam Gene Tree for NECAP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NECAP1 gene

NECAP2²

1 SIMAP similar gene for NECAP1 using alignment to 4 protein entries: NECP1_HUMAN (see all proteins):

NECAP2

NECAP1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for NECAP1
PGOHUM00000240690 PGOHUM00000232653

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs66928724^1,2	C	--	8235173(+)	`TGCCG-/TTTTTT`	1	--	int¹		2		NA CSA	4
rs58735520^1,2	C	--	8235372(+)	`CTCTCT/ACACAC`	1	--	int¹		1		CSA	2
rs58971773^1,2	C	--	8235374(+)	`CTCACT/ACACAC`	1	--	int¹		1		CSA	2
rs77652179^1,2	C	--	8235376(+)	`CACACT/ACACAC`	1	--	int¹		1		CSA	2
rs71042329^1,2	C	--	8236326(+)	`TTTTT-/TGTTAG`	1	--	int¹		1		NA	2
rs140539415^1,2	C,	--	8239525(+)	`CTATT-/ACACACA`	1	--	int¹		0	--	--	--	--
rs72293047^1,2	--	--	8235372(+)	`ACACA-/ACAC CACAC`	1	--	int¹		0	--	--	--	--
rs74897588^1,2	--	--	8235173(+)	`TTTTT-/TTGTTTT`	2	--	int¹		0	--	--	--	--
rs71042330^1,2	--	--	8238283(+)	`TTTTT-/TTGTTGT`	1	--	int¹		1		NA	2
rs72333692^1,2	--	--	8235373(+)	`ACACA-/CACA CACAC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NECAP1 (7926148 - 8176148 bp, first 250kb of NECAP1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NECAP1
2 CNVs: 3873 34469

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NECAP1

DNA2.0 Custom Variant and Variant Library Synthesis for NECAP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NECAP1 for disorders           About GeneDecksing

OMIM gene information: 611623    OMIM disorders: --

3 diseases for NECAP1:    About MalaCards

hepatitis b hepatitis neuronitis

Human Genome Epidemiology (HuGE) Navigator: NECAP1 (1 document)

Export disorders for NECAP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NECAP1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with NECAP1)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Molecular mechanisms in clathrin-mediated membrane bu dding revealed through subcellular proteomics. (PubMed id 15494011)^{1, 3} Ritter B....McPherson P.S. (2004)
Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. (PubMed id 14555962)^{1, 3} Ritter B....McPherson P.S. (2003)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)¹ Brehme M....Superti-Furga G. (2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25977	HGNC: 24539	AceView: DKFZP566B183	Ensembl:ENSG00000089818	euGenes: HUgn25977
ECgene: NECAP1	H-InvDB: NECAP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NECAP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NECAP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NECAP1 gene:
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GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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NECAP endocytosis associated 1

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NECAP endocytosis associated 1

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