Aliases for NECAP1 Gene
Aliases for NECAP1 Gene
External Ids for NECAP1 Gene
- HGNC: 24539
- Entrez Gene: 25977
- Ensembl: ENSG00000089818
- OMIM: 611623
- UniProtKB: Q8NC96
Previous GeneCards Identifiers for NECAP1 Gene
- GC12P008110
- GC12P007758
- GC12P007989
- GC12P008234
- GC12P008046
- GC12P007926
Summaries for NECAP1 Gene
-
This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for NECAP1 Gene
NECAP1 (NECAP Endocytosis Associated 1) is a Protein Coding gene. Diseases associated with NECAP1 include Epileptic Encephalopathy, Early Infantile, 21 and Undetermined Early-Onset Epileptic Encephalopathy. Among its related pathways are Clathrin derived vesicle budding and Vesicle-mediated transport. An important paralog of this gene is NECAP2.
UniProtKB/Swiss-Prot for NECAP1 Gene
-
Involved in endocytosis.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAP1 Gene
Genomics for NECAP1 Gene
Regulatory Elements for NECAP1 Gene
Enhancers for NECAP1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G008108 | 1 | Ensembl ENCODE | 46.8 | +32.1 | 32078 | 0.4 | BCOR CTCF NFIB TEAD4 MAX ZNF384 ZNF2 ZIC2 RAD21 RFX5 | NECAP1 GC12P008103 POU5F1P3 |
| GH12G008096 | 0.6 | Ensembl dbSUPER | 49.4 | +19.6 | 19562 | 0.6 | OSR2 | NECAP1 FOXJ2 GC12P008103 GC12P008091 |
| GH12G007969 | 2 | FANTOM5 Ensembl ENCODE dbSUPER | 11 | -105.7 | -105739 | 4.4 | HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 CBX5 ZNF143 ZNF207 FOS | SLC2A3 NECAP1 CLEC4A FOXJ2 CLEC6A C3AR1 GC12P007976 |
| GH12G008087 | 1.2 | Ensembl ENCODE dbSUPER | 12.8 | +11.4 | 11442 | 2.1 | TBP PKNOX1 MXI1 WRNIP1 MAX CEBPG EBF1 ZNF143 FOS ETV6 | NECAP1 C3AR1 FOXJ2 GC12P008091 CLEC4A |
| GH12G007796 | 1.2 | Ensembl ENCODE dbSUPER | 12.5 | -278.1 | -278102 | 4.6 | BCOR ZNF792 ZNF10 ZNF781 RARA JUND ZNF316 ZNF34 POLR2A ZBTB33 | FAM66C GNB3 NECAP1 ENO2 DPPA3 DEFB109F RPL13P5 DSTNP2 SLC2A3 NANOG |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around NECAP1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for NECAP1 Gene
- Chromosome:
- 12
- Start:
- 8,076,939 bp from pter
- End:
- 8,097,859 bp from pter
- Size:
- 20,921 bases
- Orientation:
- Plus strand
Genomic View for NECAP1 Gene
Genes around NECAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.31 by Ensembl
- 12p13.31 by Entrez Gene
- 12p13.31 by HGNC
NECAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NECAP1 Gene
Proteins for NECAP1 Gene
-
Protein details for NECAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8NC96-NECP1_HUMAN
- Recommended name:
- Adaptin ear-binding coat-associated protein 1
- Protein Accession:
- Q8NC96
- Q2NL73
- Q5XG95
- Q6NWY6
- Q8N153
- Q8NCB0
- Q9BU52
- Q9Y407
Protein attributes for NECAP1 Gene
- Size:
- 275 amino acids
- Molecular mass:
- 29737 Da
- Quaternary structure:
-
- Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity).
- SequenceCaution:
-
- Sequence=AAH02888.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for NECAP1 Gene
Post-translational modifications for NECAP1 Gene
Other Protein References for NECAP1 Gene
Antibody Products
- Novus Biologicals Antibodies for NECAP1
- Invitrogen Antibodies for NECAP1
- antibodies-online Antibodies for NECAP1: See all 9
- Search GeneTex for Antibodies for NECAP1
Protein Products
-
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- antibodies-online Proteins for NECAP1: See all 7
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Assay Products
- antibodies-online Kits for NECAP1: See all 4
No data available for DME Specific Peptides for NECAP1 Gene
Domains & Families for NECAP1 Gene
Protein Domains for NECAP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NECAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q8NC96UniProtKB/Swiss-Prot:
NECP1_HUMAN :- The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself. The WXXF motif 1, which is preceded by an acidic residue and has a glycine in second position mediates specific interaction with AP-1. The WXXF motif 2, which is followed by the C-terminal carboxyl group negative charge, allows specific interaction with AP-2 (By similarity).
- Belongs to the NECAP family.
- Domain:
-
- The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself. The WXXF motif 1, which is preceded by an acidic residue and has a glycine in second position mediates specific interaction with AP-1. The WXXF motif 2, which is followed by the C-terminal carboxyl group negative charge, allows specific interaction with AP-2 (By similarity).
- Family:
-
- Belongs to the NECAP family.
No data available for Gene Families for NECAP1 Gene
Function for NECAP1 Gene
Molecular function for NECAP1 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in endocytosis.
Phenotypes for NECAP1 Gene
- GenomeRNAi human phenotypes for NECAP1:
Animal Model Products
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-
-
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-
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-
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miRNA for NECAP1 Gene
- miRTarBase miRNAs that target NECAP1
-
- hsa-mir-1254 (MIRT035856)
- hsa-mir-423-5p (MIRT038063)
- hsa-mir-1207-5p (MIRT067285)
- hsa-mir-2054 (MIRT067286)
- hsa-mir-4310 (MIRT067288)
- hsa-mir-4763-3p (MIRT067290)
- hsa-mir-5197-5p (MIRT067293)
- hsa-mir-6132 (MIRT067294)
- hsa-mir-6836-5p (MIRT067296)
- hsa-mir-7150 (MIRT067298)
- hsa-mir-7157-5p (MIRT067299)
- hsa-mir-32-5p (MIRT136291)
- hsa-mir-92a-3p (MIRT136292)
- hsa-mir-335-3p (MIRT136300)
- hsa-mir-92b-3p (MIRT136301)
- hsa-mir-5096 (MIRT485309)
- hsa-mir-513a-5p (MIRT485310)
- hsa-mir-4736 (MIRT485311)
- hsa-mir-27b-3p (MIRT485312)
- hsa-mir-27a-3p (MIRT485313)
miRNA Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for NECAP1 Gene
Localization for NECAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NECAP1 Gene
- Cytoplasmic vesicle, clathrin-coated vesicle membrane. Cell membrane. Note=Colocalizes with AP-2 at the plasma membrane. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| extracellular | 1 |
| nucleus | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0030665 | clathrin-coated vesicle membrane | IEA | -- |
| GO:0031410 | cytoplasmic vesicle | IEA | -- |
Pathways & Interactions for NECAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Clathrin derived vesicle budding | ||
| 2 | Clathrin-mediated endocytosis | ||
| 3 | Vesicle-mediated transport | ||
Pathways by source for NECAP1 Gene
Interacting Proteins for NECAP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0006897 | endocytosis | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0061024 | membrane organization | TAS | -- |
No data available for SIGNOR curated interactions for NECAP1 Gene
Transcripts for NECAP1 Gene
mRNA/cDNA for NECAP1 Gene
- (1) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (237) Selected AceView cDNA sequences:
- (27) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NECAP1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NECAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for NECAP1
- GenScript: Design CRISPR guide RNA sequences for NECAP1
miRNA Products
- Search ViGene Biosciences for NECAP1
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for NECAP1
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-
ViGene Biosciences ready-to-package AAV shRNAs for NECAP1 gene
Clone Products
-
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for NECAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NECAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||
| SP6: |
Expression for NECAP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Brain (Nervous System)
This gene is overexpressed in Brain (33.5), Fetal Brain (8.9), and Breast (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NECAP1 Gene
NURSA nuclear receptor signaling pathways regulating expression of NECAP1 Gene:
NECAP1SOURCE GeneReport for Unigene cluster for NECAP1 Gene:
Hs.555927Evidence on tissue expression from TISSUES for NECAP1 Gene
- Nervous system(5)
- Kidney(4.2)
- Lung(4.2)
- Muscle(4.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NECAP1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- cerebellum
- cranial nerve
- eye
- face
- forehead
- head
- lip
- mouth
- nose
- pharynx
- skull
Thorax:
- chest wall
- diaphragm
- esophagus
- lung
- rib
- rib cage
Abdomen:
- abdominal wall
- intestine
- large intestine
- stomach
Pelvis:
- pelvis
- rectum
Limb:
- digit
- finger
- foot
- hand
- lower limb
- upper limb
General:
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for NECAP1
-
OriGene qPCR primer pairs and template standards for NECAP1
No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NECAP1 Gene
Orthologs for NECAP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NECAP1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | NECAP1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | NECAP1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Necap1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Necap1 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NECAP1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NECAP1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NECAP1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.17597 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | necap1 34 35 |
|
||
| zgc73124 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000322 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9132 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y110A2AR.3 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2050 35 |
|
OneToMany |
- Species where no ortholog for NECAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NECAP1 Gene
(1) SIMAP similar genes for NECAP1 Gene using alignment to 4 proteins:
Pseudogenes.org Pseudogenes for NECAP1 Gene
Variants for NECAP1 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs587777420 | other | 8,089,982(+) | GCCTC(C/T)GAATC | nc-transcript-variant, reference, stop-gained | |
| rs1000311108 | -- | 8,087,056(+) | AATCA(A/G)TATTA | intron-variant | |
| rs1000377207 | -- | 8,093,418(+) | CTTAT(C/T)TACAA | intron-variant | |
| rs1000791754 | -- | 8,091,078(+) | TCTTC(C/T)ACAAA | intron-variant | |
| rs1000806277 | -- | 8,081,950(+) | CGTCA(C/T)GATTC | upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759877 | CNV | gain+loss | 17122850 |
| nsv1045521 | CNV | gain | 25217958 |
| nsv428270 | CNV | gain | 18775914 |
| nsv475738 | CNV | novel sequence insertion | 20440878 |
Residual Variation Intolerance Score:
39.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.44;
28.22% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for NECAP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECAP1 Gene
Disorders for NECAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epileptic encephalopathy, early infantile, 21 |
|
|
| undetermined early-onset epileptic encephalopathy |
|
|
| infantile epileptic encephalopathy |
|
|
| cataract 8, multiple types |
|
|
| hypertonia |
|
|
Search NECAP1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
NECP1_HUMAN- Epileptic encephalopathy, early infantile, 21 (EIEE21) [MIM:615833]: A severe disease characterized by intractable seizures, profound global developmental delay, and persistent severe axial hypotonia as well as appendicular hypertonia. {ECO:0000269 PubMed:24399846}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for NECAP1
No data available for Genatlas for NECAP1 Gene
Publications for NECAP1 Gene
- NECAP1 loss of function leads to a severe infantile epileptic encephalopathy. (PMID: 24399846) Alazami A.M. … Alkuraya F.S. (J. Med. Genet. 2014) 3 4 64
- Characterization of the localization and function of NECAP 1 in neurons. (PMID: 16879712) Murshid A. … Presley J.F. (J. Neurochem. 2006) 3 22 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Molecular mechanisms in clathrin-mediated membrane budding revealed through subcellular proteomics. (PMID: 15494011) Ritter B. … McPherson P.S. (Biochem. Soc. Trans. 2004) 2 3 64
Products for NECAP1 Gene
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- VectorBuilder custom plasmid, inducible vectors for NECAP1
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for NECAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer