Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NECAP1 Gene

protein-coding   GIFtS: 54
GCID: GC12P008234

NECAP Endocytosis Associated 1

  See NECAP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
NECAP Endocytosis Associated 11 2
NECAP-12 3
NECAP Endocytosis-Associated Protein 12 3
Adaptin Ear-Binding Coat-Associated Protein 12
Adaptin-Ear-Binding Coat-Associated Protein 12

External Ids:    HGNC: 245391   Entrez Gene: 259772   Ensembl: ENSG000000898187   OMIM: 6116235   UniProtKB: Q8NC963   

Export aliases for NECAP1 gene to outside databases

Previous GC identifers: GC12P008110 GC12P007758 GC12P007989 GC12P008046 GC12P007926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NECAP1 Gene:
NECAP1 (NECAP endocytosis associated 1) is a protein-coding gene. Diseases associated with NECAP1 include epileptic encephalopathy, early infantile, 21. An important paralog of this gene is NECAP2.

UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96
Function: Involved in endocytosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the NECAP1 gene promoter:
         Bach1   Elk-1   AML1a   Pbx1a   Pax-2   Pax-2a   AP-2gamma   FOXO4   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNECAP1 promoter sequence
   Search Chromatin IP Primers for NECAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NECAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

NECAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NECAP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P008234:  view genomic region     (about GC identifiers)

Start:
8,234,807 bp from pter      End:
8,250,373 bp from pter
Size:
15,567 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96 (See protein sequence)
Recommended Name: Adaptin ear-binding coat-associated protein 1  
Size: 275 amino acids; 29737 Da
Subunit: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with
the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity)
Sequence caution: Sequence=AAH02888.1; Type=Erroneous initiation;
Secondary accessions: Q2NL73 Q5XG95 Q6NWY6 Q8N153 Q8NCB0 Q9BU52 Q9Y407
Alternative splicing: 2 isoforms:  Q8NC96-1   Q8NC96-2   

Explore the universe of human proteins at neXtProt for NECAP1: NX_Q8NC96

Explore proteomics data for NECAP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NECAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056324.2  
    ENSEMBL proteins: 
     ENSP00000341737   ENSP00000401963   ENSP00000440658   ENSP00000439319  
    Reactome Protein details: Q8NC96

    NECAP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NECAP1
    OriGene Protein Over-expression Lysate for NECAP1
    OriGene MassSpec for NECAP1
    OriGene Custom Protein Services for NECAP1
    GenScript Custom Purified and Recombinant Proteins Services for NECAP1
    Novus Biologicals NECAP1 Protein
    Novus Biologicals NECAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NECAP1

     
    Search eBioscience for Proteins for NECAP1 

    NECAP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NECAP1
    Novus Biologicals NECAP1 Antibodies
    Abcam antibodies for NECAP1
    Cloud-Clone Corp. Antibodies for NECAP1
    Search ThermoFisher Antibodies for NECAP1
    Search LSBio for Antibodies for NECAP1

    NECAP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NECAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NECAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NECAP1
    Cloud-Clone Corp. CLIAs for NECAP1
    Search eBioscience for ELISAs for NECAP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR012466 NECAP-1

    Graphical View of Domain Structure for InterPro Entry Q8NC96

    ProtoNet protein and cluster: Q8NC96

    1 Blocks protein domain: IPB012466 Protein of unknown function DUF1681

    UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96
    Domain: The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through
    hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is
    tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself.
    The WXXF motif 1, which is preceded by an acidic residue and has a glycine in second position mediates specific
    interaction with AP-1. The WXXF motif 2, which is followed by the C-terminal carboxyl group negative charge,
    allows specific interaction with AP-2 (By similarity)
    Similarity: Belongs to the NECAP family


    Find genes that share domains with NECAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NECP1_HUMAN, Q8NC96
    Function: Involved in endocytosis (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with NECAP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NECAP1:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NECAP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NECAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NECAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NECAP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NECAP1:
    hsa-mir-1254 (MIRT035856), hsa-mir-423-5p (MIRT038063)

    Block miRNA regulation of human, mouse, rat NECAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NECAP1 (see all 49):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-25 hsa-miR-1245 hsa-miR-30d hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidNECAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NECAP1
    Predesigned siRNA for gene silencing in human, mouse, rat NECAP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NECAP1

    Clone
    Products:
         
    OriGene clones in human, mouse for NECAP1 (see all 6)
    OriGene ORF clones in mouse, rat for NECAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NECAP1 (NM_015509)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NECAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NECAP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NECAP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NECAP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NECP1_HUMAN, Q8NC96: Cytoplasmic vesicle, clathrin-coated vesicle membrane (By similarity). Cell membrane (By
    similarity). Note=Colocalizes with AP-2 at the plasma membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    plasma membrane2
    extracellular1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0005905coated pit IEA--
    GO:0016020membrane ----
    GO:0030125clathrin vesicle coat IEA--

    Find genes that share ontologies with NECAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NECAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Clathrin derived vesicle budding0.89
    trans-Golgi Network Vesicle Budding0.89
    Golgi Associated Vesicle Biogenesis0.89
    Membrane Trafficking0.32


    Find genes that share SuperPaths with NECAP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for NECAP1
        Golgi Associated Vesicle Biogenesis


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NECAP1
    Interactions:

        Search GeneGlobe Interaction Network for NECAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NECAP1 (Q8NC963 ENSP000003417374) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAB2P980823, ENSP000003133914I2D: score=2 STRING: ENSP00000313391
    AP2M1Q96CW13, ENSP000002928074I2D: score=1 STRING: ENSP00000292807
    AP1G1O437473, ENSP000003771484I2D: score=1 STRING: ENSP00000377148
    AMPHP494183, ENSP000003486024I2D: score=1 STRING: ENSP00000348602
    HIP1O002913, ENSP000003367474I2D: score=1 STRING: ENSP00000336747
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0015031protein transport IEA--

    Find genes that share ontologies with NECAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NECAP1 (NECP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NECAP1 gene: 
    NM_015509.3  

    Unigene Cluster for NECAP1:

    NECAP endocytosis associated 1
    Hs.555927  [show with all ESTs]
    Unigene Representative Sequence: AK094805
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339754(uc001qtx.2 uc001qty.2) ENST00000546181 ENST00000542095
    ENST00000545807 ENST00000450991 ENST00000544891 ENST00000541948 ENST00000540083
    ENST00000537796
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NECAP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NECAP1 (see all 49):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-25 hsa-miR-1245 hsa-miR-30d hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidNECAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NECAP1
    Predesigned siRNA for gene silencing in human, mouse, rat NECAP1
    Clone
    Products:
         
    OriGene clones in human, mouse for NECAP1 (see all 6)
    OriGene ORF clones in mouse, rat for NECAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NECAP1 (NM_015509)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NECAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NECAP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NECAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for NECAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NECAP1
      QuantiTect SYBR Green Assays in human, mouse, rat NECAP1
      QuantiFast Probe-based Assays in human, mouse, rat NECAP1

    Additional mRNA sequence: 

    AK074858.1 AK074880.1 AK074923.1 AK075013.1 AK094805.1 AK290537.1 AK303675.1 AK314424.1 
    BC002888.2 BC067367.1 BC084551.1 BC110876.1 NR_024260.1 

    13 DOTS entries:

    DT.444700  DT.100819919  DT.100819926  DT.121195735  DT.99966761  DT.121195718  DT.100740210  DT.99963654 
    DT.100683552  DT.95203526  DT.121195703  DT.91968296  DT.95203494 

    Selected AceView cDNA sequences (see all 237):

    BI761766 AA773971 AW241262 BM546167 F10486 BI791447 AK074858 BQ012587 
    BP368413 AU279603 AA666244 CK820570 AW169556 AV706346 AA688259 CD674835 
    BC067367 AA325376 F12883 BP362061 Z40959 CR622227 AA863072 BM479330 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NECAP1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                      -     -                 -     -                                 
    SP2:                                      -     -                                                         
    SP3:                                                                                                      
    SP4:                                      -     -                                                         
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for NECAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NECAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTGTTCTT
    NECAP1 Expression
    About this image


    NECAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    NECAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NECAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.555927
        Custom PCR Arrays for NECAP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NECAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for NECAP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NECAP1
    QuantiTect SYBR Green Assays in human, mouse, rat NECAP1
    QuantiFast Probe-based Assays in human, mouse, rat NECAP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NECAP1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Necap11 , 5 NECAP endocytosis associated 11, 5 89.7(n)1
    94.18(a)1
      6 (57.96 cM)5
    676021  NM_026267.21  NP_080543.21 
     1228745575 
    chicken
    (Gallus gallus)
    Aves NECAP11 NECAP endocytosis associated 1 76.54(n)
    81.85(a)
      770083  XM_003640439.2  XP_003640487.1 
    lizard
    (Anolis carolinensis)
    Reptilia NECAP16
    NECAP endocytosis associated 1
    74(a)
    1 ↔ 1
    GL343236.1(1163113-1186590)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054244.12   -- 76.97(n)    BC054244.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731242 hypothetical protein MGC73124 75.37(n)   393695  BC059487.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG91321 CG9132 56.05(n)
    54.69(a)
      2768881  NM_206767.2  NP_996490.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y110A2AR.36
    Protein Y110A2AR.3, isoform a
    47(a)
    1 → many
    II(2913711-2919314) WBGene00022453


    ENSEMBL Gene Tree for NECAP1 (if available)
    TreeFam Gene Tree for NECAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NECAP1 gene
    NECAP22  
    1 SIMAP similar gene for NECAP1 using alignment to 4 protein entries:     NECP1_HUMAN (see all proteins):
    NECAP2

    Find genes that share paralogs with NECAP1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NECAP1
    PGOHUM00000240690 PGOHUM00000232653


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NECAP1 (see all 385)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1839606491,2
    --8115491(+) AATAAA/GGAACA 2 -- us2k10--------
    rs1507895531,2
    --8115558(+) AATAAC/TAGCTA 2 -- us2k10--------
    rs740600231,2
    C,F--8115644(+) GAAAGC/TCTTCT 2 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1392195211,2
    --8115663(+) TTACAC/TGCATG 2 -- us2k10--------
    rs1396907641,2
    C--8115715(+) TGTAT-/GTTTTT 2 -- us2k10--------
    rs1499248591,2
    --8115876(+) GTATTA/GTTGTA 2 -- us2k10--------
    rs1897728681,2
    C--8115887(+) CATACA/TTTTTT 2 -- us2k10--------
    rs355088381,2
    C,F--8115919(+) CAATAT/CTTATT 2 -- us2k16Minor allele frequency- C:0.22WA NA 246
    rs1806739101,2
    --8116050(+) TCCTCA/GCGTCC 2 -- us2k10--------
    rs1859830141,2
    --8116084(+) TCTTTC/TTGAAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NECAP1 (8234807 - 8250373 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NECAP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428270CNV Gain18775914
    dgv455e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NECAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for NECAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611623    OMIM disorders: --

    1 disease for NECAP1:    
    About MalaCards
    epileptic encephalopathy, early infantile, 21


    Find genes that share disorders with NECAP1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: NECAP1 (1 document)

    Export disorders for NECAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NECAP1 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with NECAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Molecular mechanisms in clathrin-mediated membrane budding revealed through subcellular proteomics. (PubMed id 15494011)1, 3 Ritter B....McPherson P.S. (Biochem. Soc. Trans. 2004)
    4. Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. (PubMed id 14555962)1, 3 Ritter B....McPherson P.S. (EMBO Rep. 2003)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    9. Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 25977 HGNC: 24539 AceView: DKFZP566B183 Ensembl:ENSG00000089818 euGenes: HUgn25977
    ECgene: NECAP1 H-InvDB: NECAP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NECAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NECAP1 gene:
    Search GeneIP for patents involving NECAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NECAP1  
     OriGene qPCR primer pairs and template standards for NECAP1   OriGene Protein Over-expression Lysate for NECAP1  
     OriGene MassSpec something-or-other for NECAP1   OriGene clones in human, mouse for NECAP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NECAP1   OriGene Purified Protein for NECAP1  
     OriGene ORF clones in mouse, rat for NECAP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NECAP1   OriGene Custom Protein Services for NECAP1  

     
     
     Block miRNA regulation of human, mouse, rat NECAP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NECAP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NECAP1 Predesigned siRNA for gene silencing in human, mouse, rat NECAP1
     QuantiFast Probe-based Assays in human, mouse, rat NECAP1 QuantiTect SYBR Green Assays in human, mouse, rat NECAP1
     Custom PCR Arrays for NECAP1 Search Chromatin IP Primers for NECAP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NECAP1  Search GeneGlobe Interaction Network for NECAP1
     Regulatory tfbs in NECAP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NECAP1 GenScript cDNA clones with any tag delivered in your preferred vector for NECAP1
     GenScript Custom Assay Services for NECAP1 GenScript Custom overexpressing Cell Line Services for NECAP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NECAP1 (NECP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NECAP1 antibodies
     NECAP1 proteins
     NECAP1 lysates
     Antibodies for NECAP1
     See all of Abcam's Antibodies, Kits and Proteins for NECAP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NECAP1
     Antibodies for NECAP1
     ELISAs for NECAP1
     CLIAs for NECAP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for NECAP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAP1
     SwitchGear 3'UTR luciferase reporter plasmids for NECAP1
     SwitchGear Promoter luciferase reporter plasmids for NECAP1
     Search ThermoFisher Antibodies for NECAP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NECAP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NECAP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NECAP1
     Search LSBio for Antibodies for NECAP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NECAP1
      Search eBioscience for proteins for NECAP1
      Search eBioscience for elisas for NECAP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NECAP1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4