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Set Analyses:

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NECAP1 Gene

protein-coding GIFtS: 54
GCID: GC12P008234

NECAP Endocytosis Associated 1

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
NECAP Endocytosis Associated 1¹ ²
NECAP-1² ³
NECAP Endocytosis-Associated Protein 1² ³
Adaptin Ear-Binding Coat-Associated Protein 1²
Adaptin-Ear-Binding Coat-Associated Protein 1²

External Ids:	HGNC: 24539¹	Entrez Gene: 25977²	Ensembl: ENSG00000089818⁷	OMIM: 611623⁵	UniProtKB: Q8NC96³

Export aliases for NECAP1 gene to outside databases

Previous GC identifers: GC12P008110 GC12P007758 GC12P007989 GC12P008046 GC12P007926

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NECAP1 Gene:

NECAP1 (NECAP endocytosis associated 1) is a protein-coding gene. Diseases associated with NECAP1 include hepatitis b, and hepatitis. An important paralog of this gene is NECAP2.

UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96

Function: Involved in endocytosis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000012.12 NC_018923.2 NT_009714.18

Regulatory elements:

Regulatory transcription factor binding sites in the NECAP1 gene promoter:
Bach1 Elk-1 AML1a Pbx1a Pax-2 Pax-2a AP-2gamma FOXO4 Pax-4a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NECAP1 promoter sequence

Search Chromatin IP Primers for NECAP1

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NECAP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31

NECAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NECAP1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P008234: view genomic region (about GC identifiers)

Start:	8,234,807 bp from pter	End:	8,250,373 bp from pter
Size:	15,567 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96 (See protein sequence)

Recommended Name: Adaptin ear-binding coat-associated protein 1

Size: 275 amino acids; 29737 Da

Subunit: Interacts with AP1G1 and AP2A1 components of the adapter protein complexes AP-1 and AP-2. Interacts with

the GAE domain proteins GGA1, GGA2 and GGA3 (By similarity)

Sequence caution: Sequence=AAH02888.1; Type=Erroneous initiation;

Secondary accessions: Q2NL73 Q5XG95 Q6NWY6 Q8N153 Q8NCB0 Q9BU52 Q9Y407

Alternative splicing: 2 isoforms: Q8NC96-1 Q8NC96-2

Explore the universe of human proteins at neXtProt for NECAP1: NX_Q8NC96

Explore proteomics data for NECAP1 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See NECAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_056324.2

ENSEMBL proteins:

ENSP00000341737 ENSP00000401963 ENSP00000440658 ENSP00000439319

Reactome Protein details: Q8NC96

NECAP1 Human Recombinant Protein Products:

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NECAP1 Assay Products:

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	Cloud-Clone Corp. ELISAs for NECAP1 Cloud-Clone Corp. CLIAs for NECAP1

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:

IPR011993 PH_like_dom

IPR012466 NECAP-1

Graphical View of Domain Structure for InterPro Entry Q8NC96

ProtoNet protein and cluster: Q8NC96

1 Blocks protein domain: IPB012466 Protein of unknown function DUF1681

UniProtKB/Swiss-Prot: NECP1_HUMAN, Q8NC96

Domain: The WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs and AP-2 through

hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is

tuned by the acidic context surrounding the motif and the properties of the second residue of the motif itself.

The WXXF motif 1, which is preceded by an acidic residue and has a glycine in second position mediates specific

interaction with AP-1. The WXXF motif 2, which is followed by the C-terminal carboxyl group negative charge,

allows specific interaction with AP-2 (By similarity)

Similarity: Belongs to the NECAP family

NECAP1 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: NECP1_HUMAN, Q8NC96

Function: Involved in endocytosis (By similarity)

Gene Ontology (GO): 1 molecular function term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

NECAP1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for NECAP1:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NECAP1

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NECAP1

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NECAP1

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NECAP1

miRNA Products:		miRTarBase miRNAs that target NECAP1: hsa-mir-1254 (MIRT035856), hsa-mir-423-5p (MIRT038063)

		Block miRNA regulation of human, mouse, rat NECAP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate NECAP1 (see all 49):
		hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-25 hsa-miR-1245 hsa-miR-30d hsa-miR-105

		SwitchGear 3'UTR luciferase reporter plasmid: NECAP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NECAP1
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Gene Editing
Products:

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Clone Products:		OriGene clones in human, mouse for NECAP1 (see all 6) OriGene ORF clones in mouse, rat for NECAP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAP1

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

NECP1_HUMAN, Q8NC96: Cytoplasmic vesicle, clathrin-coated vesicle membrane (By similarity). Cell membrane (By

similarity). Note=Colocalizes with AP-2 at the plasma membrane (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	2
cytosol	2
plasma membrane	2
extracellular	1
nucleus	1

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Gene Ontology (GO): 4 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005905	coated pit	IEA	--
GO:0016020	membrane	--	--
GO:0030125	clathrin vesicle coat	IEA	--

NECAP1 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NECAP1 About

See pathways by source

SuperPath

Contained pathways About

Clathrin derived vesicle budding

	Clathrin derived vesicle budding	0.89			trans-Golgi Network Vesicle Budding	0.89
	Golgi Associated Vesicle Biogenesis	0.89			Membrane Trafficking	0.32

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for NECAP1

Golgi Associated Vesicle Biogenesis

NECAP1 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for NECAP1
Interactions:

Search GeneGlobe Interaction Network for NECAP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NECAP1 (Q8NC96³ ENSP00000341737⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 64)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DAB2	P98082³, ENSP00000313391⁴	I2D: score=2 STRING: ENSP00000313391
AP2M1	Q96CW1³, ENSP00000292807⁴	I2D: score=1 STRING: ENSP00000292807
AP1G1	O43747³, ENSP00000377148⁴	I2D: score=1 STRING: ENSP00000377148
AMPH	P49418³, ENSP00000348602⁴	I2D: score=1 STRING: ENSP00000348602
HIP1	O00291³, ENSP00000336747⁴	I2D: score=1 STRING: ENSP00000336747

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Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	IEA	--
GO:0015031	protein transport	IEA	--

NECAP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for NECAP1 (NECP1)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NECAP1 gene:

NM_015509.3

Unigene Cluster for NECAP1:

NECAP endocytosis associated 1

Hs.555927 [show with all ESTs]

Unigene Representative Sequence: AK094805

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000339754(uc001qtx.2 uc001qty.2) ENST00000546181 ENST00000542095

ENST00000545807 ENST00000450991 ENST00000544891 ENST00000541948 ENST00000540083

ENST00000537796

miRNA Products:		Block miRNA regulation of human, mouse, rat NECAP1 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate NECAP1 (see all 49):
		hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-513a-5p hsa-miR-25 hsa-miR-1245 hsa-miR-30d hsa-miR-105

		SwitchGear 3'UTR luciferase reporter plasmid: NECAP1 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for NECAP1
		Predesigned siRNA for gene silencing in human, mouse, rat NECAP1

Clone Products:		OriGene clones in human, mouse for NECAP1 (see all 6) OriGene ORF clones in mouse, rat for NECAP1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NECAP1 (NM_015509)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NECAP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NECAP1

Primer Products:		OriGene qPCR primer pairs and template standards for NECAP1 OriGene qSTAR qPCR primer pairs in human, mouse for NECAP1
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat NECAP1
		QuantiTect SYBR Green Assays in human, mouse, rat NECAP1
		QuantiFast Probe-based Assays in human, mouse, rat NECAP1

Additional mRNA sequence:

AK074858.1 AK074880.1 AK074923.1 AK075013.1 AK094805.1 AK290537.1 AK303675.1 AK314424.1

BC002888.2 BC067367.1 BC084551.1 BC110876.1 NR_024260.1

13 DOTS entries:

DT.444700 DT.100819919 DT.100819926 DT.121195735 DT.99966761 DT.121195718 DT.100740210 DT.99963654

DT.100683552 DT.95203526 DT.121195703 DT.91968296 DT.95203494

Selected AceView cDNA sequences (see all 237):

BI761766 AA773971 AW241262 BM546167 F10486 BI791447 AK074858 BQ012587

BP368413 AU279603 AA666244 CK820570 AW169556 AV706346 AA688259 CD674835

BC067367 AA325376 F12883 BP362061 Z40959 CR622227 AA863072 BM479330

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for NECAP1 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7	^	8a	·	8b
SP1:													-		-						-		-
SP2:													-		-
SP3:
SP4:													-		-
SP5:

ECgene alternative splicing isoforms for NECAP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NECAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTGTGTTCTT

About this image

NECAP1 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Blood (Hematopoietic System)
Granulocytes Peripheral Blood

NECAP1 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

NECAP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.555927

Custom PCR Arrays for NECAP1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for NECAP1 gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Necap1^{1 , 5}	NECAP endocytosis associated 1^{1, 5}	89.7(n)¹ 94.18(a)¹		6 (57.96 cM)⁵ 67602¹ NM_026267.2¹ NP_080543.2¹ 122874557⁵
chicken (Gallus gallus)	Aves	NECAP1¹	NECAP endocytosis associated 1	76.54(n) 81.85(a)		770083 XM_003640439.2 XP_003640487.1
lizard (Anolis carolinensis)	Reptilia	NECAP1⁶	NECAP endocytosis associated 1	74(a)	1 ↔ 1	GL343236.1(1163113-1186590)
African clawed frog (Xenopus laevis)	Amphibia	BC054244.1²	--	76.97(n)		BC054244.1
zebrafish (Danio rerio)	Actinopterygii	zgc73124²	hypothetical protein MGC73124	75.37(n)		393695 BC059487.1
fruit fly (Drosophila melanogaster)	Insecta	CG9132¹	CG9132	56.05(n) 54.69(a)		2768881 NM_206767.2 NP_996490.1
worm (Caenorhabditis elegans)	Secernentea	Y110A2AR.3⁶	Protein Y110A2AR.3, isoform a	47(a)	1 → many	II(2913711-2919314) WBGene00022453

ENSEMBL Gene Tree for NECAP1 (if available)
TreeFam Gene Tree for NECAP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for NECAP1 gene

NECAP2²

1 SIMAP similar gene for NECAP1 using alignment to 4 protein entries: NECP1_HUMAN (see all proteins):

NECAP2

NECAP1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for NECAP1
PGOHUM00000240690 PGOHUM00000232653

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183960649^1,2		--	8115491(+)	`AATAAA/GGAACA`	2	--	us2k¹		0	--	--	--	--
rs150789553^1,2		--	8115558(+)	`AATAAC/TAGCTA`	2	--	us2k¹		0	--	--	--	--
rs74060023^1,2	C,F	--	8115644(+)	`GAAAGC/TCTTCT`	2	--	us2k¹		2		WA	120
rs139219521^1,2		--	8115663(+)	`TTACAC/TGCATG`	2	--	us2k¹		0	--	--	--	--
rs139690764^1,2	C	--	8115715(+)	`TGTAT-/GTTTTT`	2	--	us2k¹		0	--	--	--	--
rs149924859^1,2		--	8115876(+)	`GTATTA/GTTGTA`	2	--	us2k¹		0	--	--	--	--
rs189772868^1,2	C	--	8115887(+)	`CATACA/TTTTTT`	2	--	us2k¹		0	--	--	--	--
rs35508838^1,2	C,F	--	8115919(+)	`CAATAT/CTTATT`	2	--	us2k¹		6		WA NA	246
rs180673910^1,2		--	8116050(+)	`TCCTCA/GCGTCC`	2	--	us2k¹		0	--	--	--	--
rs185983014^1,2		--	8116084(+)	`TCTTTC/TTGAAA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NECAP1 (8234807 - 8250373 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for NECAP1: About this table

Variant ID	Type	Subtype	PubMed ID
nsv428270	CNV	Gain	18775914
dgv455e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing NECAP1

DNA2.0 Custom Variant and Variant Library Synthesis for NECAP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611623 OMIM disorders: --

4 diseases for NECAP1:
About MalaCards

hepatitis b hepatitis malaria neuronitis

NECAP1 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: NECAP1 (1 document)

Export disorders for NECAP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for NECAP1 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with NECAP1)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Molecular mechanisms in clathrin-mediated membrane budding revealed through subcellular proteomics. (PubMed id 15494011)^{1, 3} Ritter B....McPherson P.S. (Biochem. Soc. Trans. 2004)
Identification of a family of endocytic proteins that define a new alpha-adaptin ear-binding motif. (PubMed id 14555962)^{1, 3} Ritter B....McPherson P.S. (EMBO Rep. 2003)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (Genes Immun. 2010)
Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)¹ Brehme M....Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (BMC Genomics 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25977	HGNC: 24539	AceView: DKFZP566B183	Ensembl:ENSG00000089818	euGenes: HUgn25977
ECgene: NECAP1	H-InvDB: NECAP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for NECAP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NECAP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NECAP1 gene:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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NECAP1 Gene

NECAP Endocytosis Associated 1

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NECAP1 Gene

NECAP Endocytosis Associated 1

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