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NECAB3 Gene

protein-coding   GIFtS: 50
GCID: GC20M032244

N-Terminal EF-Hand Calcium Binding Protein 3

(Previous names: amyloid beta (A4) precursor protein-binding, family A, member...)
(Previous symbols: SYTIP2, APBA2BP)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Terminal EF-Hand Calcium Binding Protein 31 2     X11L-Binding Protein 512 3
APBA2BP1 2 3 5     EFCBP32 5
SYTIP21 2 3     STIP32 5
NIP12 3 5     dJ63M2.42
XB512 3 5     dJ63M2.52
Amyloid Beta (A4) Precursor Protein-Binding, Family A, Member 2 Binding
Protein1 2
     N-Terminal EF-Hand Calcium-Binding Protein 32
EF-Hand Calcium Binding Protein 31 2     Neuronal Calcium-Binding Protein NECAB32
Amyloid Beta A4 Protein-Binding Family A Member 2-Binding Protein2 3     Synaptotagmin Interacting Protein 22
Neuronal Calcium-Binding Protein 32 3     Synaptotagmin Interacting Protein STIP32
Nek2-Interacting Protein 12 3     

External Ids:    HGNC: 158511   Entrez Gene: 639412   Ensembl: ENSG000001259677   OMIM: 6124785   UniProtKB: Q96P713   

Export aliases for NECAB3 gene to outside databases

Previous GC identifers: GC20M031709 GC20M029030


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NECAB3 Gene:
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein
(X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and
abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an
important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The
protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NECAB3 Gene:
NECAB3 (N-terminal EF-hand calcium binding protein 3) is a protein-coding gene. Diseases associated with NECAB3 include neuronitis, and chronic lymphocytic leukemia. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB1.

UniProtKB/Swiss-Prot: NECA3_HUMAN, Q96P71
Function: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation
of beta-amyloid

Gene Wiki entry for NECAB3 (APBA2BP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NECAB3 gene promoter:
         Sp1   GCNF   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNECAB3 promoter sequence
   Search Chromatin IP Primers for NECAB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NECAB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.21

NECAB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NECAB3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M032244:  view genomic region     (about GC identifiers)

Start:
32,244,893 bp from pter      End:
32,262,269 bp from pter
Size:
17,377 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NECA3_HUMAN, Q96P71 (See protein sequence)
Recommended Name: N-terminal EF-hand calcium-binding protein 3  
Size: 396 amino acids; 44350 Da
Subunit: Interacts with the N-terminal domain of APBA2. Interacts with NEK2
Sequence caution: Sequence=BAB14649.1; Type=Frameshift; Positions=56; Sequence=BAB16413.1; Type=Erroneous
initiation;
Secondary accessions: A8K780 E1P5N2 Q5JWF5 Q5JWF6 Q5JWF7 Q86VV1 Q9H433 Q9H8G8 Q9HBW7 Q9HCQ9
Alternative splicing: 3 isoforms:  Q96P71-1   Q96P71-2   Q96P71-3   (May result from the retention of an intron in the cDNA)

Explore the universe of human proteins at neXtProt for NECAB3: NX_Q96P71

Explore proteomics data for NECAB3 at MOPED

Post-translational modifications: 

  • Phosphorylated by NEK21
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NECAB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_112508.3  NP_112509.3  

    ENSEMBL proteins: 
     ENSP00000246190   ENSP00000364386   ENSP00000475938   ENSP00000475369   ENSP00000475834  
     ENSP00000475420   ENSP00000392064   ENSP00000476044   ENSP00000475755   ENSP00000476165  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NECAB: N-terminal EF-hand calcium binding proteins
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR007138 Antibiotic_mOase
     IPR011008 Dimeric_a/b-barrel
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q96P71

    ProtoNet protein and cluster: Q96P71

    1 Blocks protein domain: IPB007138 Antibiotic biosynthesis monooxygenase

    UniProtKB/Swiss-Prot: NECA3_HUMAN, Q96P71
    Similarity: Contains 1 ABM domain
    Similarity: Contains 1 EF-hand domain


    NECAB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NECA3_HUMAN, Q96P71
    Function: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation
    of beta-amyloid

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI10833507
         
    NECAB3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NECAB3
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    Selected qRT-PCR Assays for microRNAs that regulate NECAB3 (see all 12):
    hsa-miR-125a-5p hsa-miR-137 hsa-miR-944 hsa-miR-650 hsa-miR-637 hsa-miR-125b hsa-miR-670 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidNECAB3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NECAB3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NECA3_HUMAN, Q96P71: Golgi apparatus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    nucleus5
    extracellular3
    cytosol1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000137Golgi cis cisterna IDA10833507
    GO:0005634nucleus NAS10833507
    GO:0005737cytoplasm IDA10833507
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IDA10833507

    NECAB3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NECAB3
    Interactions:

        GeneGlobe Interaction Network for NECAB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for NECAB3 (Q96P713 ENSP000002461904) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    APBA2Q997673I2D: score=3 
    SF3A2ENSP000002214944STRING: ENSP00000221494
    NCBP1ENSP000003642894STRING: ENSP00000364289
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009306protein secretion NAS12780348
    GO:0019538protein metabolic process IDA12780348
    GO:0042984regulation of amyloid precursor protein biosynthetic process IDA10833507

    NECAB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NECAB3 (NECA3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NECAB3 gene (2 alternative transcripts): 
    NM_031231.3  NM_031232.3  

    Unigene Cluster for NECAB3:

    N-terminal EF-hand calcium binding protein 3
    Hs.516986  [show with all ESTs]
    Unigene Representative Sequence: NM_031232
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000477778 ENST00000246190(uc002wzn.4) ENST00000375238(uc002wzl.3 uc002wzm.4)
    ENST00000606525 ENST00000488489(uc002wzo.4) ENST00000483813 ENST00000485399
    ENST00000485976 ENST00000478237 ENST00000494174 ENST00000463246 ENST00000480994
    ENST00000606690 ENST00000439478 ENST00000607805 ENST00000498353 ENST00000493590
    ENST00000606106

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NECAB3 (see all 12):
    hsa-miR-125a-5p hsa-miR-137 hsa-miR-944 hsa-miR-650 hsa-miR-637 hsa-miR-125b hsa-miR-670 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidNECAB3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NECAB3
      QuantiFast Probe-based Assays in human, mouse, rat NECAB3

    Additional mRNA sequence: 

    AB039947.1 AF193759.1 AF409141.1 AK124388.1 AK291895.1 BC023270.1 BC047673.1 

    22 DOTS entries:

    DT.442829  DT.100792217  DT.91943655  DT.100792213  DT.95079738  DT.101982010  DT.120827151  DT.92428753 
    DT.95113107  DT.100792214  DT.120827146  DT.120827154  DT.92428755  DT.97848827  DT.100662363  DT.100774865 
    DT.100792212  DT.444073  DT.91985746  DT.95113115  DT.97848828  DT.92428756 

    Selected AceView cDNA sequences (see all 181):

    AI872258 NM_031232 CR610365 BM806357 AA609873 AI918962 CK904035 BF514598 
    CR617645 BQ010631 BQ027299 BI966137 CR614917 AA025666 CR626345 BM847196 
    AI336556 BU616700 CR624229 BF981126 BI820266 AW444512 BI965982 BQ067649 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NECAB3 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                          -                 -                 -                                       
    SP2:                          -                 -                                                         
    SP3:                          -                                   -                                       
    SP4:                                            -                 -     -                                 
    SP5:                          -                                   -                                       


    ECgene alternative splicing isoforms for NECAB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NECAB3 expression in normal human tissues (normalized intensities)      NECAB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NECAB3 Expression
    About this image


    NECAB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neurons
             AII Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             AII Amacrine Cells Inner Nuclear Layer
     
     Ovary (Reproductive System)
    NECAB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NECAB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516986

    UniProtKB/Swiss-Prot: NECA3_HUMAN, Q96P71
    Tissue specificity: Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NECAB3 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Necab31 , 5 N-terminal EF-hand calcium binding protein 31, 5 85.17(n)1
    86.97(a)1
      2 (76.79 cM)5
    568461  NM_021546.31  NP_067521.21 
     1545443995 
    chicken
    (Gallus gallus)
    Aves NECAB31 N-terminal EF-hand calcium binding protein 3 67.05(n)
    60.63(a)
      419154  NM_001030850.1  NP_001026021.1 
    lizard
    (Anolis carolinensis)
    Reptilia NECAB36
    N-terminal EF-hand calcium binding protein 3
    55(a)
    1 ↔ 1
    4(136555671-136662287)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004979381 N-terminal EF-hand calcium-binding protein 1-like 58.2(n)
    51.11(a)
      100497938  XM_002932881.2  XP_002932927.2 
    zebrafish
    (Danio rerio)
    Actinopterygii NECAB36
    N-terminal EF-hand calcium binding protein 3
    44(a)
    1 ↔ 1
    6(57491850-57570574) ENSDARG00000074794


    ENSEMBL Gene Tree for NECAB3 (if available)
    TreeFam Gene Tree for NECAB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NECAB3 gene
    NECAB12  NECAB22  
    3 SIMAP similar genes for NECAB3 using alignment to 8 protein entries:     NECA3_HUMAN (see all proteins):
    APBA2BP    NECAB1    NECAB2

    NECAB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NECAB3 (see all 230)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49113551,2
    C,F,A,H--32244414(+) CAGGGG/ACCTCC 2 -- ds50018Minor allele frequency- A:0.05EA NS NA 904
    rs558936011,2
    C,F--32244519(+) AGGACT/GGACTC 2 -- ds50012Minor allele frequency- G:0.17WA 120
    rs732598531,2
    C,F--32244584(+) TGGTGG/AGGACA 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1509267501,2
    --32244665(+) CTGCAA/GAGACA 2 -- ds50010--------
    rs61193951,2
    C,F,A,H--32244711(+) GGTGTG/TTCAGG 2 -- ds500113Minor allele frequency- T:0.32NS EA NA WA CSA 740
    rs1843969881,2
    --32244815(+) CAAGAA/GAGGTG 2 -- ds50010--------
    rs1159567721,2
    C,F--32244865(+) CACAGC/TCCAGA 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs60882721,2
    H--32244872(+) CAGACC/TTGCGA 2 -- ds50013Minor allele frequency- T:0.00NS EA 298
    rs1497739761,2
    C--32244946(+) GGTTC-/AAGAGG 2 -- ut310--------
    rs1152391091,2
    F--32244959(+) TCTGGG/AGGCAA 2 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for NECAB3 (32244893 - 32262269 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NECAB3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833960CNV Loss17160897
    dgv4565n71CNV Loss21882294
    dgv4564n71CNV Loss21882294
    nsv833961CNV Loss17160897
    nsv482067CNV Gain20164927

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NECAB3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612478    OMIM disorders: --

    6 diseases for NECAB3:    About MalaCards
    neuronitis    chronic lymphocytic leukemia    hepatitis b    alzheimer's disease
    hepatitis    leukemia


    NECAB3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Human Genome Epidemiology (HuGE) Navigator: NECAB3 (2 documents)

    Export disorders for NECAB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NECAB3 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with NECAB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. (PubMed id 10833507)1, 2, 3, 9 Lee D.-S.... Suzuki T. (J. Biol. Chem. 2000)
    2. NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. (PubMed id 14697346)1, 2 Yoo J.C....Rhee K. (Exp. Cell Res. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PubMed id 12044471)1, 2 Sugita S.... Suedhof T.C. (Neuroscience 2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. (PubMed id 12780348)1, 9 Sumioka A....Suzuki T. (Biochem. J. 2003)
    8. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63941 HGNC: 15851 AceView: APBA2BP Ensembl:ENSG00000125967 euGenes: HUgn63941
    ECgene: NECAB3 H-InvDB: NECAB3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NECAB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NECAB3 gene:
    Search GeneIP for patents involving NECAB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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