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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NECAB3 Gene

protein-coding   GIFtS: 51
GCID: GC20M032244

N-Terminal EF-Hand Calcium Binding Protein 3

(Previous names: amyloid beta (A4) precursor protein-binding, family A, member...)
(Previous symbols: SYTIP2, APBA2BP)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Terminal EF-Hand Calcium Binding Protein 31 2     X11L-Binding Protein 512 3
APBA2BP1 2 3 5     EFCBP32 5
SYTIP21 2 3     STIP32 5
NIP12 3 5     dJ63M2.42
XB512 3 5     dJ63M2.52
Amyloid Beta (A4) Precursor Protein-Binding, Family A, Member 2 Binding
Protein1 2
     N-Terminal EF-Hand Calcium-Binding Protein 32
EF-Hand Calcium Binding Protein 31 2     Neuronal Calcium-Binding Protein NECAB32
Amyloid Beta A4 Protein-Binding Family A Member 2-Binding Protein2 3     Synaptotagmin Interacting Protein 22
Neuronal Calcium-Binding Protein 32 3     Synaptotagmin Interacting Protein STIP32
Nek2-Interacting Protein 12 3     

External Ids:    HGNC: 158511   Entrez Gene: 639412   Ensembl: ENSG000001259677   OMIM: 6124785   UniProtKB: Q96P713   

Export aliases for NECAB3 gene to outside databases

Previous GC identifers: GC20M031709 GC20M029030


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NECAB3 Gene:
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein
(X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and
abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an
important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The
protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NECAB3 Gene: 
NECAB3 (N-terminal EF-hand calcium binding protein 3) is a protein-coding gene. Diseases associated with NECAB3 include neuronitis, and chronic lymphocytic leukemia. GO annotations related to this gene include protein binding and calcium ion binding. An important paralog of this gene is NECAB1.

UniProtKB/Swiss-Prot: NECA3_HUMAN, Q96P71
Function: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation
of beta-amyloid

Gene Wiki entry for NECAB3 (APBA2BP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NECAB3 gene promoter:
         Sp1   GCNF   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNECAB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NECAB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NECAB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.22   Ensembl cytogenetic band:  20q11.22   HGNC cytogenetic band: 20q11.21

NECAB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NECAB3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M032244:  view genomic region     (about GC identifiers)

Start:
32,244,893 bp from pter      End:
32,262,269 bp from pter
Size:
17,377 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NECA3_HUMAN, Q96P71 (See protein sequence)
Recommended Name: N-terminal EF-hand calcium-binding protein 3  
Size: 396 amino acids; 44350 Da
Subunit: Interacts with the N-terminal domain of APBA2. Interacts with NEK2
Subcellular location: Golgi apparatus
Sequence caution: Sequence=BAB14649.1; Type=Frameshift; Positions=56; Sequence=BAB16413.1; Type=Erroneous
initiation;
Secondary accessions: A8K780 E1P5N2 Q5JWF5 Q5JWF6 Q5JWF7 Q86VV1 Q9H433 Q9H8G8 Q9HBW7 Q9HCQ9
Alternative splicing: 3 isoforms:  Q96P71-1   Q96P71-2   Q96P71-3   (May result from the retention of an intron in the cDNA)

Explore the universe of human proteins at neXtProt for NECAB3: NX_Q96P71

Explore proteomics data for NECAB3 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by NEK2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96P71

  • NECAB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NECAB3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_112508.3  NP_112509.3  

    ENSEMBL proteins: 
     ENSP00000246190   ENSP00000364386   ENSP00000475938   ENSP00000475369   ENSP00000475834  
     ENSP00000475420   ENSP00000392064   ENSP00000476044   ENSP00000475755   ENSP00000476165  

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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000137Golgi cis cisterna IDA10833507
    GO:0005634nucleus NAS10833507
    GO:0005737cytoplasm IDA10833507
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IDA10833507

    NECAB3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NECAB: N-terminal EF-hand calcium binding proteins
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR007138 Antibiotic_mOase
     IPR011008 Dimeric_a/b-barrel
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q96P71

    ProtoNet protein and cluster: Q96P71

    1 Blocks protein domain: IPB007138 Antibiotic biosynthesis monooxygenase

    UniProtKB/Swiss-Prot: NECA3_HUMAN, Q96P71
    Similarity: Contains 1 ABM domain
    Similarity: Contains 1 EF-hand domain


    NECAB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NECA3_HUMAN, Q96P71
    Function: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation
    of beta-amyloid

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI10833507
         
    NECAB3 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidNECAB3 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NECAB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for NECAB3 (Q96P713 ENSP000002461904) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    IKBKGQ9Y6K93, ENSP000003586224I2D: score=1 STRING: ENSP00000358622
    APBA2Q997673I2D: score=3 
    SF3A2ENSP000002214944STRING: ENSP00000221494
    NCBP1ENSP000003642894STRING: ENSP00000364289
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009306protein secretion NAS12780348
    GO:0019538protein metabolic process IDA12780348
    GO:0042984regulation of amyloid precursor protein biosynthetic process IDA10833507

    NECAB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NECAB3 (NECA3)

    Search CenterWatch for drugs/clinical trials and news about NECAB3 / NECA3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for NECAB3 gene (2 alternative transcripts): 
    NM_031231.3  NM_031232.3  

    Unigene Cluster for NECAB3:

    N-terminal EF-hand calcium binding protein 3
    Hs.516986  [show with all ESTs]
    Unigene Representative Sequence: NM_031232
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000477778 ENST00000246190(uc002wzn.4) ENST00000375238(uc002wzl.3 uc002wzm.4)
    ENST00000606525 ENST00000488489(uc002wzo.4) ENST00000483813 ENST00000485399
    ENST00000485976 ENST00000478237 ENST00000494174 ENST00000463246 ENST00000480994
    ENST00000606690 ENST00000439478 ENST00000607805 ENST00000498353 ENST00000493590
    ENST00000606106

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    Additional mRNA sequence: 

    AB039947.1 AF193759.1 AF409141.1 AK124388.1 AK291895.1 BC023270.1 BC047673.1 

    22 DOTS entries:

    DT.442829  DT.100792217  DT.91943655  DT.100792213  DT.95079738  DT.101982010  DT.120827151  DT.92428753 
    DT.95113107  DT.100792214  DT.120827146  DT.120827154  DT.92428755  DT.97848827  DT.100662363  DT.100774865 
    DT.100792212  DT.444073  DT.91985746  DT.95113115  DT.97848828  DT.92428756 

    24/181 AceView cDNA sequences (see all 181):

    BF514598 BI965982 BM847196 BI966137 AI336556 AI872258 CK904035 CR624229 
    BM806357 AI918962 NM_031232 BQ010631 CR603836 AW444512 AA025666 BQ027299 
    BQ067649 CR617645 CB216810 CR626345 BU616700 CR614917 BI820266 AA609873 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NECAB3 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                          -                 -                 -                                       
    SP2:                          -                 -                                                         
    SP3:                          -                                   -                                       
    SP4:                                            -                 -     -                                 
    SP5:                          -                                   -                                       


    ECgene alternative splicing isoforms for NECAB3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NECAB3 expression in normal human tissues (normalized intensities)      NECAB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NECAB3 Expression
    About this image


    NECAB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Adrenal Gland (Endocrine System)
             adrenal cortex   
     
     Uterus (Reproductive System)
             cervix   
     
     Eye (Sensory Organs)
             AII Amacrine Cells Inner Nuclear Layer

    See NECAB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NECAB3

    SOURCE GeneReport for Unigene cluster: Hs.516986

    UniProtKB/Swiss-Prot: NECA3_HUMAN, Q96P71
    Tissue specificity: Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NECAB3 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Necab31 , 5 N-terminal EF-hand calcium binding protein 31, 5 85.17(n)1
    87.54(a)1
      2 (76.79 cM)5
    568461  NM_021546.31  NP_067521.21 
     1545443995 
    chicken
    (Gallus gallus)
    Aves NECAB31 N-terminal EF-hand calcium binding protein 3 67.53(n)
    61.03(a)
      419154  NM_001030850.1  NP_001026021.1 
    lizard
    (Anolis carolinensis)
    Reptilia NECAB36
    Uncharacterized protein
    55(a)
    1 ↔ 1
    4(136555671-136662287)
    zebrafish
    (Danio rerio)
    Actinopterygii NECAB36
    N-terminal EF-hand calcium binding protein 3
    48(a)
    1 ↔ 1
    6(57533945-57570205)


    ENSEMBL Gene Tree for NECAB3 (if available)
    TreeFam Gene Tree for NECAB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NECAB3 gene
    NECAB12  NECAB22  
    3 SIMAP similar genes for NECAB3 using alignment to 1 protein entry:     NECA3_HUMAN:
    APBA2BP    NECAB1    NECAB2

    NECAB3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/230 SNPs in NECAB3 are shown (see all 230)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49113551,2
    C,F,A,H--32244414(+) CAGGGG/ACCTCC 2 -- ds50018Minor allele frequency- A:0.05EA NS NA 904
    rs558936011,2
    C,F--32244519(+) AGGACT/GGACTC 2 -- ds50012Minor allele frequency- G:0.17WA 120
    rs732598531,2
    C,F--32244584(+) TGGTGG/AGGACA 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1509267501,2
    --32244665(+) CTGCAA/GAGACA 2 -- ds50010--------
    rs61193951,2
    C,F,A,H--32244711(+) GGTGTG/TTCAGG 2 -- ds500113Minor allele frequency- T:0.32NS EA NA WA CSA 740
    rs1843969881,2
    --32244815(+) CAAGAA/GAGGTG 2 -- ds50010--------
    rs1159567721,2
    C,F--32244865(+) CACAGC/TCCAGA 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs60882721,2
    H--32244872(+) CAGACC/TTGCGA 2 -- ds50013Minor allele frequency- T:0.00NS EA 298
    rs1497739761,2
    C--32244946(+) GGTTC-/AAGAGG 2 -- ut310--------
    rs1152391091,2
    F--32244959(+) TCTGGG/AGGCAA 2 -- ut311Minor allele frequency- A:0.02WA 118

    HapMap Linkage Disequilibrium report for NECAB3 (32244893 - 32262269 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NECAB3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833960CNV Loss17160897
    dgv4565n71CNV Loss21882294
    dgv4564n71CNV Loss21882294
    nsv833961CNV Loss17160897
    nsv482067CNV Gain20164927

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612478    OMIM disorders: --

    6 diseases for NECAB3:    About MalaCards
    neuronitis    chronic lymphocytic leukemia    hepatitis b    alzheimer's disease
    hepatitis    leukemia


    NECAB3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Human Genome Epidemiology (HuGE) Navigator: NECAB3 (2 documents)

    Export disorders for NECAB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NECAB3 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with NECAB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. (PubMed id 10833507)1, 2, 3, 9 Lee D.-S.... Suzuki T. (2000)
    2. NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi. (PubMed id 14697346)1, 2 Yoo J.C....Rhee K. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PubMed id 12044471)1, 2 Sugita S.... Suedhof T.C. (2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. (PubMed id 12780348)1, 9 Sumioka A....Suzuki T. (2003)
    8. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63941 HGNC: 15851 AceView: APBA2BP Ensembl:ENSG00000125967 euGenes: HUgn63941
    ECgene: NECAB3 H-InvDB: NECAB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NECAB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NECAB3 gene:
    Search GeneIP for patents involving NECAB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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