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Aliases for NECAB3 Gene

Aliases for NECAB3 Gene

  • N-Terminal EF-Hand Calcium Binding Protein 3 2 3
  • Amyloid Beta (A4) Precursor Protein-Binding, Family A, Member 2 Binding Protein 2 3
  • Amyloid Beta A4 Protein-Binding Family A Member 2-Binding Protein 3 4
  • Neuronal Calcium-Binding Protein 3 3 4
  • EF-Hand Calcium Binding Protein 3 2 3
  • Nek2-Interacting Protein 1 3 4
  • X11L-Binding Protein 51 3 4
  • APBA2BP 3 4
  • SYTIP2 3 4
  • NIP1 3 4
  • XB51 3 4
  • Neuronal Calcium-Binding Protein NECAB3 3
  • Synaptotagmin Interacting Protein STIP3 3
  • Synaptotagmin Interacting Protein 2 3
  • DJ63M2.4 3
  • DJ63M2.5 3
  • EFCBP3 3
  • STIP3 3

External Ids for NECAB3 Gene

Previous HGNC Symbols for NECAB3 Gene

  • SYTIP2

Previous GeneCards Identifiers for NECAB3 Gene

  • GC20M031709
  • GC20M032244
  • GC20M029030

Summaries for NECAB3 Gene

Entrez Gene Summary for NECAB3 Gene

  • The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NECAB3 Gene

NECAB3 (N-Terminal EF-Hand Calcium Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB2.

UniProtKB/Swiss-Prot for NECAB3 Gene

  • Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid.

Gene Wiki entry for NECAB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAB3 Gene

Genomics for NECAB3 Gene

Regulatory Elements for NECAB3 Gene

Genomic Location for NECAB3 Gene

33,657,087 bp from pter
33,674,463 bp from pter
17,377 bases
Minus strand

Genomic View for NECAB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NECAB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECAB3 Gene

Proteins for NECAB3 Gene

  • Protein details for NECAB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-terminal EF-hand calcium-binding protein 3
    Protein Accession:
    Secondary Accessions:
    • A8K780
    • E1P5N2
    • Q5JWF5
    • Q5JWF6
    • Q5JWF7
    • Q86VV1
    • Q9H433
    • Q9H8G8
    • Q9HBW7
    • Q9HCQ9

    Protein attributes for NECAB3 Gene

    396 amino acids
    Molecular mass:
    44350 Da
    Quaternary structure:
    • Interacts with the N-terminal domain of APBA2. Interacts with NEK2.
    • Sequence=BAB14649.1; Type=Frameshift; Positions=56; Evidence={ECO:0000305}; Sequence=BAB16413.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NECAB3 Gene


neXtProt entry for NECAB3 Gene

Proteomics data for NECAB3 Gene at MOPED

Post-translational modifications for NECAB3 Gene

Antibody Products

No data available for DME Specific Peptides for NECAB3 Gene

Domains & Families for NECAB3 Gene

Suggested Antigen Peptide Sequences for NECAB3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ABM domain.
  • Contains 1 ABM domain.
  • Contains 1 EF-hand domain.
genes like me logo Genes that share domains with NECAB3: view

Function for NECAB3 Gene

Molecular function for NECAB3 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid.

Gene Ontology (GO) - Molecular Function for NECAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 10833507
genes like me logo Genes that share ontologies with NECAB3: view

Phenotypes for NECAB3 Gene

GenomeRNAi human phenotypes for NECAB3:
genes like me logo Genes that share phenotypes with NECAB3: view

Animal Model Products

CRISPR Products

miRNA for NECAB3 Gene

miRTarBase miRNAs that target NECAB3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NECAB3 Gene

Localization for NECAB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECAB3 Gene

Golgi apparatus.

Subcellular locations from

Jensen Localization Image for NECAB3 Gene COMPARTMENTS Subcellular localization image for NECAB3 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for NECAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000137 Golgi cis cisterna IDA 10833507
GO:0005634 nucleus NAS 10833507
GO:0005737 cytoplasm IDA 10833507
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IDA 10833507
genes like me logo Genes that share ontologies with NECAB3: view

Pathways & Interactions for NECAB3 Gene

SuperPathways for NECAB3 Gene

No Data Available

Interacting Proteins for NECAB3 Gene

Gene Ontology (GO) - Biological Process for NECAB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion NAS 12780348
GO:0019538 protein metabolic process IDA 12780348
GO:0042984 regulation of amyloid precursor protein biosynthetic process IDA 10833507
genes like me logo Genes that share ontologies with NECAB3: view

No data available for Pathways by source and SIGNOR curated interactions for NECAB3 Gene

Drugs & Compounds for NECAB3 Gene

No Compound Related Data Available

Transcripts for NECAB3 Gene

Unigene Clusters for NECAB3 Gene

N-terminal EF-hand calcium binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NECAB3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: - -
SP6: - - - - -
SP7: - -

Relevant External Links for NECAB3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NECAB3 Gene

mRNA expression in normal human tissues for NECAB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for NECAB3 Gene Hs.516986

mRNA Expression by UniProt/SwissProt for NECAB3 Gene

Tissue specificity: Strongly expressed in heart and skeletal muscle, moderately in brain and pancreas.
genes like me logo Genes that share expression patterns with NECAB3: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NECAB3 Gene

Orthologs for NECAB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECAB3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NECAB3 35
  • 87.15 (n)
  • 87.15 (a)
  • 84 (a)
(Canis familiaris)
Mammalia NECAB3 35
  • 88.49 (n)
  • 86.91 (a)
  • 81 (a)
(Mus musculus)
Mammalia Necab3 35
  • 85.17 (n)
  • 86.97 (a)
Necab3 16
Necab3 36
  • 82 (a)
(Pan troglodytes)
Mammalia NECAB3 35
  • 98.25 (n)
  • 97.51 (a)
  • 97 (a)
(Rattus norvegicus)
Mammalia Necab3 35
  • 84.69 (n)
  • 87.21 (a)
(Monodelphis domestica)
Mammalia NECAB3 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia NECAB3 36
  • 43 (a)
(Gallus gallus)
Aves NECAB3 35
  • 67.05 (n)
  • 60.63 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia NECAB3 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497938 35
  • 58.2 (n)
  • 51.11 (a)
(Danio rerio)
Actinopterygii NECAB3 36
  • 44 (a)
Species with no ortholog for NECAB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECAB3 Gene

Gene Tree for NECAB3 (if available)
Gene Tree for NECAB3 (if available)

Paralogs for NECAB3 Gene

Paralogs for NECAB3 Gene

(3) SIMAP similar genes for NECAB3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with NECAB3: view

Variants for NECAB3 Gene

Sequence variations from dbSNP and Humsavar for NECAB3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1045770 -- 33,657,142(-) GGCCT(C/T)TGAAC utr-variant-3-prime, nc-transcript-variant
rs1062945 -- 33,657,468(-) GCTTT(C/T)TTCCT utr-variant-3-prime, nc-transcript-variant
rs1062951 -- 33,657,283(-) GGCCT(C/T)TGGGT utr-variant-3-prime, nc-transcript-variant
rs1062954 -- 33,657,227(-) CCATT(C/T)TCAGG utr-variant-3-prime, nc-transcript-variant
rs2626541 -- 33,670,474(-) AAATA(A/G)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NECAB3 Gene

Variant ID Type Subtype PubMed ID
nsv833960 CNV Loss 17160897
nsv833961 CNV Loss 17160897
dgv4564n71 CNV Loss 21882294
dgv4565n71 CNV Loss 21882294
nsv482067 CNV Gain 20164927

Variation tolerance for NECAB3 Gene

Residual Variation Intolerance Score: 77.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NECAB3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECAB3 Gene

Disorders for NECAB3 Gene

Relevant External Links for NECAB3

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NECAB3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NECAB3 Gene

Publications for NECAB3 Gene

  1. Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. (PMID: 10833507) Lee D.-S. … Suzuki T. (J. Biol. Chem. 2000) 2 23 67
  2. XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. (PMID: 12780348) Sumioka A. … Suzuki T. (Biochem. J. 2003) 23 67
  3. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PMID: 22623531) Toyoshima M. … Grandori C. (Proc. Natl. Acad. Sci. U.S.A. 2012) 67
  4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PMID: 21048031) Casabonne D. … de Sanjose S. (Haematologica 2011) 67
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67

Products for NECAB3 Gene

Sources for NECAB3 Gene

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