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Aliases for NECAB2 Gene

Aliases for NECAB2 Gene

  • N-Terminal EF-Hand Calcium Binding Protein 2 2 3
  • Synaptotagmin-Interacting Protein 2 3 4
  • Neuronal Calcium-Binding Protein 2 3 4
  • EF-Hand Calcium Binding Protein 2 2 3
  • EF-Hand Calcium-Binding Protein 2 3 4
  • Stip-2 3 4
  • EFCBP2 3 4
  • N-Terminal EF-Hand Calcium-Binding Protein 2 3
  • EF Hand Calcium Binding Protein 2 3
  • Neuronal Calcium Binding 2 3

External Ids for NECAB2 Gene

Previous Symbols for NECAB2 Gene

  • EFCBP2

Summaries for NECAB2 Gene

GeneCards Summary for NECAB2 Gene

NECAB2 (N-Terminal EF-Hand Calcium Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB3.

Gene Wiki entry for NECAB2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAB2 Gene

Genomics for NECAB2 Gene

Genomic Location for NECAB2 Gene

Start:
83,968,632 bp from pter
End:
84,002,776 bp from pter
Size:
34,145 bases
Orientation:
Plus strand

Genomic View for NECAB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NECAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECAB2 Gene

Regulatory Elements for NECAB2 Gene

Proteins for NECAB2 Gene

  • Protein details for NECAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6G3-NECA2_HUMAN
    Recommended name:
    N-terminal EF-hand calcium-binding protein 2
    Protein Accession:
    Q7Z6G3
    Secondary Accessions:
    • A2RRG3
    • O75547
    • Q6ZSK0

    Protein attributes for NECAB2 Gene

    Size:
    386 amino acids
    Molecular mass:
    43194 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI31616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86948.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NECAB2 Gene

Proteomics data for NECAB2 Gene at MOPED

Post-translational modifications for NECAB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NECAB2 Gene

No data available for DME Specific Peptides for NECAB2 Gene

Domains for NECAB2 Gene

Gene Families for NECAB2 Gene

HGNC:
  • EFHAND :EF-hand domain containing
  • NECAB :N-terminal EF-hand calcium binding proteins

UniProtKB/Swiss-Prot:

NECA2_HUMAN
Domain:
  • Contains 1 ABM domain.:
    • Q7Z6G3
  • Contains 2 EF-hand domains.:
    • Q7Z6G3
genes like me logo Genes that share domains with NECAB2: view

Function for NECAB2 Gene

Gene Ontology (GO) - Molecular Function for NECAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 17689978
genes like me logo Genes that share ontologies with NECAB2: view

Phenotypes for NECAB2 Gene

GenomeRNAi human phenotypes for NECAB2:
genes like me logo Genes that share phenotypes with NECAB2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NECAB2 Gene

Localization for NECAB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECAB2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NECAB2 Gene COMPARTMENTS Subcellular localization image for NECAB2 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NECAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NECAB2: view

Pathways for NECAB2 Gene

SuperPathways for NECAB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NECAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
genes like me logo Genes that share ontologies with NECAB2: view

No data available for Pathways by source for NECAB2 Gene

Transcripts for NECAB2 Gene

Unigene Clusters for NECAB2 Gene

N-terminal EF-hand calcium binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NECAB2 Gene

No ASD Table

Relevant External Links for NECAB2 Gene

GeneLoc Exon Structure for
NECAB2
ECgene alternative splicing isoforms for
NECAB2

Expression for NECAB2 Gene

mRNA expression in normal human tissues for NECAB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NECAB2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.9), Brain - Amygdala (7.0), Brain - Caudate (basal ganglia) (6.5), Brain - Putamen (basal ganglia) (5.7), Brain - Anterior cingulate cortex (BA24) (4.9), and Brain - Hypothalamus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NECAB2 Gene

SOURCE GeneReport for Unigene cluster for NECAB2 Gene Hs.140950

mRNA Expression by UniProt/SwissProt for NECAB2 Gene

Q7Z6G3-NECA2_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expressions with NECAB2: view

Orthologs for NECAB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECAB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NECAB2 36
  • 98.53 (n)
  • 98.45 (a)
NECAB2 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NECAB2 36
  • 85.77 (n)
  • 85.77 (a)
NECAB2 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NECAB2 36
  • 84.23 (n)
  • 83.33 (a)
mouse
(Mus musculus)
Mammalia Necab2 36
  • 83.68 (n)
  • 85.49 (a)
Necab2 16
Necab2 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NECAB2 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NECAB2 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Necab2 36
  • 81.85 (n)
  • 82.52 (a)
chicken
(Gallus gallus)
Aves NECAB2 36
  • 71.87 (n)
  • 66.15 (a)
NECAB2 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NECAB2 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731915 36
  • 70.85 (n)
  • 69.85 (a)
zebrafish
(Danio rerio)
Actinopterygii necab2 36
  • 67.86 (n)
  • 66.82 (a)
necab2 37
  • 50 (a)
OneToOne
Species with no ortholog for NECAB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECAB2 Gene

ENSEMBL:
Gene Tree for NECAB2 (if available)
TreeFam:
Gene Tree for NECAB2 (if available)

Paralogs for NECAB2 Gene

Paralogs for NECAB2 Gene

Selected SIMAP similar genes for NECAB2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NECAB2: view

Variants for NECAB2 Gene

Sequence variations from dbSNP and Humsavar for NECAB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3880 -- 84,002,744(-) CTGGG(C/T)ACAGT utr-variant-3-prime
rs3881 -- 84,002,720(-) CTAGG(C/T)TGGGC utr-variant-3-prime
rs748059 -- 83,973,960(-) CCACC(C/T)GCCCA intron-variant
rs889631 -- 83,973,158(+) GGGGA(A/G)GAGCA intron-variant
rs889632 -- 83,973,164(+) GAGCA(C/G)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NECAB2 Gene

Variant ID Type Subtype PubMed ID
nsv517566 CNV Gain+Loss 19592680
nsv471106 CNV Gain 18288195
dgv2928n71 CNV Loss 21882294
nsv528396 CNV Loss 19592680
nsv907038 CNV Gain 21882294
nsv907040 CNV Loss 21882294
nsv457591 CNV Loss 19166990
dgv357n27 CNV Loss 19166990
nsv457594 CNV Loss 19166990
esv28321 CNV Loss 19812545
nsv827780 CNV Loss 20364138

Relevant External Links for NECAB2 Gene

HapMap Linkage Disequilibrium report
NECAB2

Disorders for NECAB2 Gene

Relevant External Links for NECAB2

Genetic Association Database (GAD)
NECAB2
Human Genome Epidemiology (HuGE) Navigator
NECAB2
genes like me logo Genes that share disorders with NECAB2: view

No data available for UniProtKB/Swiss-Prot for NECAB2 Gene

Publications for NECAB2 Gene

  1. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PMID: 12044471) Sugita S. … Suedhof T.C. (Neuroscience 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PMID: 18519826) Uhl G.R. … Lerman C. (Arch. Gen. Psychiatry 2008) 3 49

Products for NECAB2 Gene

Sources for NECAB2 Gene

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