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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NECAB2 Gene

protein-coding   GIFtS: 50
GCID: GC16P084002

N-Terminal EF-Hand Calcium Binding Protein 2

(Previous name: EF-hand calcium binding protein 2)
(Previous symbol: EFCBP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Terminal EF-Hand Calcium Binding Protein 21 2     EF Hand Calcium Binding Protein 22
EFCBP21 2 3     N-Terminal EF-Hand Calcium-Binding Protein 22
EF-Hand Calcium Binding Protein 21 2     Neuronal Calcium Binding 22
Neuronal Calcium-Binding Protein 22 3     stip-22
Synaptotagmin-Interacting Protein 22 3     Stip-23
EF-Hand Calcium-Binding Protein 22 3     

External Ids:    HGNC: 237461   Entrez Gene: 545502   Ensembl: ENSG000001031547   UniProtKB: Q7Z6G33   

Export aliases for NECAB2 gene to outside databases

Previous GC identifers: GC16P083744 GC16P082560 GC16P069754


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NECAB2 Gene: 
NECAB2 (N-terminal EF-hand calcium binding protein 2) is a protein-coding gene. Diseases associated with NECAB2 include neuronitis, and retinitis. GO annotations related to this gene include protein binding and calcium ion binding. An important paralog of this gene is NECAB1.

Gene Wiki entry for NECAB2 (EFCBP2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NECAB2 gene promoter:
         ER-alpha   HOXA3   AML1a   MyoD   HNF-4alpha2   E47   YY1   HNF-4alpha1   GATA-2   MZF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNECAB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NECAB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NECAB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.3   Ensembl cytogenetic band:  16q23.3   HGNC cytogenetic band: 16q23.3-q24.1

NECAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NECAB2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P084002:  view genomic region     (about GC identifiers)

Start:
84,002,237 bp from pter      End:
84,036,381 bp from pter
Size:
34,145 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NECA2_HUMAN, Q7Z6G3 (See protein sequence)
Recommended Name: N-terminal EF-hand calcium-binding protein 2  
Size: 386 amino acids; 43194 Da
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAI31616.1; Type=Erroneous initiation; Sequence=BAC86948.1; Type=Erroneous initiation;
Secondary accessions: A2RRG3 O75547 Q6ZSK0

Explore the universe of human proteins at neXtProt for NECAB2: NX_Q7Z6G3

Explore proteomics data for NECAB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z6G3

  • NECAB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NECAB2 Protein Expression
    REFSEQ proteins: NP_061938.2  
    ENSEMBL proteins: 
     ENSP00000307449   ENSP00000457354   ENSP00000455322   ENSP00000455713  

    Human Recombinant Protein Products for NECAB2: 
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    Cloud-Clone Corp. Proteins for NECAB2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    NECAB2 for ontologies           About GeneDecksing



    NECAB2 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NECAB: N-terminal EF-hand calcium binding proteins
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR007138 Antibiotic_mOase
     IPR011008 Dimeric_a/b-barrel
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q7Z6G3

    ProtoNet protein and cluster: Q7Z6G3

    1 Blocks protein domain: IPB007138 Antibiotic biosynthesis monooxygenase

    UniProtKB/Swiss-Prot: NECA2_HUMAN, Q7Z6G3
    Similarity: Contains 1 ABM domain
    Similarity: Contains 2 EF-hand domains


    NECAB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI17689978
         
    NECAB2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NECAB2:
     Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NECAB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/40 Interacting proteins for NECAB2 (Q7Z6G31, 2, 3 ENSP000003074494) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LNX1Q8TBB12, 3, ENSP000002639254MINT-67459 I2D: score=5 STRING: ENSP00000263925
    CCNKO759092, 3, ENSP000003745294MINT-66195 I2D: score=4 STRING: ENSP00000374529
    CENPOQ9BU642, 3, ENSP000002606624MINT-66522 I2D: score=4 STRING: ENSP00000260662
    FXR2P511162, 3, ENSP000002501134MINT-68287 I2D: score=4 STRING: ENSP00000250113
    TEX11Q8IYF32, 3, ENSP000003409954MINT-67182 I2D: score=4 STRING: ENSP00000340995
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----

    NECAB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NECAB2 (NECA2)

    Search CenterWatch for drugs/clinical trials and news about NECAB2 / NECA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NECAB2 gene: 
    NM_019065.2  

    Unigene Cluster for NECAB2:

    N-terminal EF-hand calcium binding protein 2
    Hs.140950  [show with all ESTs]
    Unigene Representative Sequence: BC016979
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305202(uc002fhd.3) ENST00000565691(uc002fhe.3) ENST00000566836
    ENST00000567703 ENST00000564166
    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NECAB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NECAB2

    Additional mRNA sequence: 

    AF070637.1 AF193758.1 AK127376.1 AY299331.1 BC016979.1 BC131615.1 

    3 DOTS entries:

    DT.429654  DT.100752382  DT.100752381 

    24/27 AceView cDNA sequences (see all 27):

    AK127376 BX281338 AY299331 AF070637 BC016979 NM_019065 BI488593 BI755862 
    AF193758 BI819305 BM995261 CB156405 BI551955 BI488426 BM807800 BF529612 
    BI488688 BM809002 BM887712 R56588 BI753891 AI244349 T80509 BF345121 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NECAB2 expression in normal human tissues (normalized intensities)      NECAB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCTGTAGT
    NECAB2 Expression
    About this image


    NECAB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             brain/forebrain/diencephalon   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium

    See NECAB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NECAB2

    SOURCE GeneReport for Unigene cluster: Hs.140950

    UniProtKB/Swiss-Prot: NECA2_HUMAN, Q7Z6G3
    Tissue specificity: Expressed in brain

        SABiosciences Custom PCR Arrays for NECAB2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NECAB2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Necab21 , 5 N-terminal EF-hand calcium binding protein 21, 5 84.02(n)1
    86.01(a)1
      8 (67.73 cM)5
    1171481  NM_054095.21  NP_473436.11 
     1194467195 
    chicken
    (Gallus gallus)
    Aves NECAB21 N-terminal EF-hand calcium binding protein 2 71.87(n)
    66.15(a)
      415705  XM_414072.1  XP_414072.1 
    lizard
    (Anolis carolinensis)
    Reptilia NECAB26
    Uncharacterized protein
    85(a)
    1 ↔ 1
    LGc(6949793-7121366)
    zebrafish
    (Danio rerio)
    Actinopterygii necab21 N-terminal EF-hand calcium binding protein 2 67.86(n)
    66.96(a)
      565258  NM_001030195.1  NP_001025366.1 


    ENSEMBL Gene Tree for NECAB2 (if available)
    TreeFam Gene Tree for NECAB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NECAB2 gene
    NECAB12  NECAB32  
    2 SIMAP similar genes for NECAB2 using alignment to 5 protein entries:     NECA2_HUMAN (see all proteins):
    NECAB1    NECAB3

    NECAB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1857 SNPs in NECAB2 are shown (see all 1857)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790877561,2
    C,F--84000482(+) TGCAGT/CTTTTT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1859383671,2
    --84000634(+) ACCTCA/GCCCAG 1 -- us2k10--------
    rs1429413101,2
    --84000665(+) AGAGAC/TGGGGT 1 -- us2k10--------
    rs1466302021,2
    --84000700(+) TTGAAC/GTCCTG 1 -- us2k10--------
    rs1887558981,2
    --84000831(+) TGGCTC/GTGCCC 1 -- us2k10--------
    rs1414530081,2
    --84000870(+) GAGACC/GAAGTA 1 -- us2k10--------
    rs1810822531,2
    --84000874(+) CCAAGC/TACACC 1 -- us2k10--------
    rs1861260991,2
    --84000975(+) GGATGC/GATGGA 1 -- us2k10--------
    rs1907934761,2
    --84000991(+) GGATGG/TGTGGG 1 -- us2k10--------
    rs1836592701,2
    --84001345(+) GATGGA/GTGGAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NECAB2 (84002237 - 84036381 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for NECAB2 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv357n27CNV Loss19166990
    nsv528396CNV Loss19592680
    nsv457594CNV Loss19166990
    esv28321CNV Loss19812545
    nsv827780CNV Loss20364138
    dgv2928n71CNV Loss21882294
    nsv457591CNV Loss19166990
    nsv907040CNV Loss21882294
    nsv907038CNV Gain21882294
    nsv471106CNV Gain18288195

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for NECAB2:    About MalaCards
    neuronitis    retinitis


    NECAB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NECAB2
    Human Genome Epidemiology (HuGE) Navigator: NECAB2 (2 documents)

    Export disorders for NECAB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NECAB2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with NECAB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PubMed id 12044471)1, 2, 3 Sugita S.... Suedhof T.C. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (2013)
    7. The association of metabotropic glutamate receptor ty pe 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. (PubMed id 19694902)1 Canela L....Ciruela F. (2009)
    8. The neuronal Ca(2+) -binding protein 2 (NECAB2) inter acts with the adenosine A(2A) receptor and modulates the cell surface expressio n and function of the receptor. (PubMed id 17689978)1 Canela L....Ciruela F. (2007)
    9. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54550 HGNC: 23746 AceView: EFCBP2 Ensembl:ENSG00000103154 euGenes: HUgn54550
    ECgene: NECAB2 H-InvDB: NECAB2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NECAB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NECAB2 gene:
    Search GeneIP for patents involving NECAB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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