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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NECAB2 Gene

protein-coding GIFtS: 49
GCID: GC16P084002

N-terminal EF-hand calcium binding protein 2

(Previous name: EF-hand calcium binding protein 2 )
(Previous symbol: EFCBP2)

Explore 3 diseases affiliated with
NECAB2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
N-Terminal EF-Hand Calcium Binding Protein 2¹ ²		EF Hand Calcium Binding Protein 2²
EFCBP2¹ ² ³		N-Terminal EF-Hand Calcium-Binding Protein 2²
EF-Hand Calcium Binding Protein 2¹ ²		Neuronal Calcium Binding 2²
Neuronal Calcium-Binding Protein 2² ³		Stip-2³
Synaptotagmin-Interacting Protein 2² ³		Stip-2³
EF-Hand Calcium-Binding Protein 2² ³

External Ids:	HGNC: 23746¹	Entrez Gene: 54550²	Ensembl: ENSG00000103154⁷	UniProtKB: Q7Z6G3³

Export aliases for NECAB2 gene to outside databases

Previous GC identifers: GC16P083744 GC16P082560 GC16P069754

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for NECAB2 (EFCBP2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NECAB2 gene promoter:
ER-alpha HOXA3 AML1a MyoD HNF-4alpha2 E47 YY1 HNF-4alpha1 GATA-2 MZF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NECAB2 promoter sequence

Search SABiosciences Chromatin IP Primers for NECAB2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NECAB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.3 Ensembl cytogenetic band: 16q23.3 HGNC cytogenetic band: 16q23.3-q24.1

NECAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NECAB2 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P084002: view genomic region (about GC identifiers)

Start:	84,002,237 bp from pter	End:	84,036,381 bp from pter
Size:	34,145 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NECA2_HUMAN, Q7Z6G3 (See protein sequence)

Recommended Name: N-terminal EF-hand calcium-binding protein 2

Size: 386 amino acids; 43194 Da

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=AAI31616.1; Type=Erroneous initiation; Sequence=BAC86948.1; Type=Erroneous initiation;

Secondary accessions: A2RRG3 O75547 Q6ZSK0

Explore the universe of human proteins at neXtProt for NECAB2: NX_Q7Z6G3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q7Z6G3

NECAB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061938.2

ENSEMBL proteins:

ENSP00000307449 ENSP00000457354 ENSP00000455322 ENSP00000455713

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

NECAB2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NECAB2 for domains About GeneDecksing

5 InterPro domains/families:

IPR018247 EF_Hand_1_Ca_BS

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR007138 Antibiotic_mOase

IPR011008 Dimeric_a/b-barrel

Graphical View of Domain Structure for InterPro Entry Q7Z6G3

ProtoNet protein and cluster: Q7Z6G3

1 Blocks protein family: IPB007138 Antibiotic biosynthesis monooxygenase

UniProtKB/Swiss-Prot: NECA2_HUMAN, Q7Z6G3

Similarity: Contains 1 ABM domain

Similarity: Contains 2 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAB2

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	17689978

NECAB2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NECAB2:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NECAB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

5/40 Interacting proteins for NECAB2 (Q7Z6G3^{1, 2, 3} ENSP00000307449⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LNX1	Q8TBB1²^,³, ENSP00000263925⁴	MINT-67459 I2D: score=5 STRING: ENSP00000263925
CCNK	O75909²^,³, ENSP00000374529⁴	MINT-66195 I2D: score=4 STRING: ENSP00000374529
CENPO	Q9BU64²^,³, ENSP00000260662⁴	MINT-66522 I2D: score=4 STRING: ENSP00000260662
FXR2	P51116²^,³, ENSP00000250113⁴	MINT-68287 I2D: score=4 STRING: ENSP00000250113
TEX11	Q8IYF3²^,³, ENSP00000340995⁴	MINT-67182 I2D: score=4 STRING: ENSP00000340995

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NECAB2
Search CenterWatch for drugs/clinical trials and news about NECAB2 / NECA2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for NECAB2 gene:

NM_019065.2

Unigene Cluster for NECAB2:

N-terminal EF-hand calcium binding protein 2

Hs.140950 [show with all ESTs]

Unigene Representative Sequence: BC016979

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000305202(uc002fhd.3) ENST00000565691(uc002fhe.3) ENST00000566836

ENST00000567703 ENST00000564166

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Additional cDNA sequence:

AF070637.1 AF193758.1 AK127376.1 AY299331.1 BC016979.1 BC131615.1

3 DOTS entries:

DT.429654 DT.100752382 DT.100752381

24/27 AceView cDNA sequences (see all 27):

BX281338 AF193758 BC016979 AK127376 AF070637 BI755862 NM_019065 AY299331

BI488593 BI488688 BM807800 BI551955 BM809002 BF529612 BI488426 BI819305

CB156405 BM887712 BM995261 R56588 AI244349 BF345121 BI753891 T80509

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NECAB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCCTGTAGT

About this image

NECAB2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Cholinergic Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NECAB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NECAB2

SOURCE GeneReport for Unigene cluster: Hs.140950

UniProtKB/Swiss-Prot: NECA2_HUMAN, Q7Z6G3

Tissue specificity: Expressed in brain

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NECAB2 gene from 3/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NECAB2¹	N-terminal EF-hand calcium binding protein 2	71.87(n) 66.15(a)		415705 XM_414072.1 XP_414072.1
lizard (Anolis carolinensis)	Reptilia	NECAB2⁶	--	84(a)	1 ↔ 1	LGc(7002509-7109639)
zebrafish (Danio rerio)	Actinopterygii	necab2¹	N-terminal EF-hand calcium binding protein 2	67.86(n) 66.96(a)		565258 NM_001030195.1 NP_001025366.1

ENSEMBL Gene Tree for NECAB2 (if available)
TreeFam Gene Tree for NECAB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NECAB2 gene

NECAB1² NECAB3²

3 SIMAP similar genes for NECAB2 using alignment to 5 protein entries: NECA2_HUMAN (see all proteins):

NECAB1 NECAB3 APBA2BP

NECAB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79087756^1,2	F,	--	84000482(+)	`TGCAGT/CTTTTT`	1	--	us2k¹		1		WA	118
rs185938367^1,2		--	84000634(+)	`ACCTCA/GCCCAG`	1	--	us2k¹		0	--	--	--	--
rs142941310^1,2		--	84000665(+)	`AGAGAC/TGGGGT`	1	--	us2k¹		0	--	--	--	--
rs146630202^1,2		--	84000700(+)	`TTGAAC/GTCCTG`	1	--	us2k¹		0	--	--	--	--
rs188755898^1,2		--	84000831(+)	`TGGCTC/GTGCCC`	1	--	us2k¹		0	--	--	--	--
rs141453008^1,2		--	84000870(+)	`GAGACC/GAAGTA`	1	--	us2k¹		0	--	--	--	--
rs181082253^1,2		--	84000874(+)	`CCAAGC/TACACC`	1	--	us2k¹		0	--	--	--	--
rs186126099^1,2		--	84000975(+)	`GGATGC/GATGGA`	1	--	us2k¹		0	--	--	--	--
rs190793476^1,2		--	84000991(+)	`GGATGG/TGTGGG`	1	--	us2k¹		0	--	--	--	--
rs183659270^1,2		--	84001345(+)	`GATGGA/GTGGAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NECAB2 (84002237 - 84036381 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for NECAB2
5 CNVs: 29665 29666 72643 72644 53392

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NECAB2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NECAB2 for disorders About GeneDecksing

3 diseases for NECAB2: About MalaCards

neuronitis ataxia retinitis

Human Genome Epidemiology (HuGE) Navigator: NECAB2 (2 documents)

Export disorders for NECAB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NECAB2 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with NECAB2)

Utopia: connect your pdf to the dynamic
world of online information

NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PubMed id 12044471)^{1, 2, 3} Sugita S.... Suedhof T.C. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The association of metabotropic glutamate receptor ty pe 5 with the neuronal Ca2+-binding protein 2 modulates receptor function. (PubMed id 19694902)¹ Canela L....Ciruela F. (2009)
Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)¹ Uhl G.R....Lerman C. (2008)
The neuronal Ca(2+) -binding protein 2 (NECAB2) inter acts with the adenosine A(2A) receptor and modulates the cell surface expressio n and function of the receptor. (PubMed id 17689978)¹ Canela L....Ciruela F. (2007)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Automated yeast two-hybrid screening for nuclear rece ptor-interacting proteins. (PubMed id 15604093)¹ Albers M....Koegl M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 54550	HGNC: 23746	AceView: EFCBP2	Ensembl:ENSG00000103154	euGenes: HUgn54550
ECgene: NECAB2	H-InvDB: NECAB2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NECAB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NECAB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NECAB2 gene:
Search GeneIP for patents involving NECAB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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	Browse OriGene Antibodies		OriGene shRNA RFP for NECAB2
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NECAB2
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	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NECAB2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NECAB2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NECAB2
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	GenScript Custom Purified and Recombinant Proteins Services for NECAB2		GenScript cDNA clones with any tag delivered in your preferred vector for NECAB2
	GenScript Custom Assay Services for NECAB2		GenScript Custom Superior Antibodies Services for NECAB2
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	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NECAB2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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NECAB2 Gene

N-terminal EF-hand calcium binding protein 2

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NECAB2 Gene

N-terminal EF-hand calcium binding protein 2

Aliasesfor NECAB2 gene

Summariesfor NECAB2 gene

Genomic Viewsfor NECAB2 gene

Proteinsfor NECAB2 gene

Protein Domains /Familiesfor NECAB2 gene

Functionfor NECAB2 gene

Pathways & Interactionsfor NECAB2 gene

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Genome Databases showing NECAB2 gene

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for NECAB2 gene

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