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Aliases for NECAB2 Gene

Aliases for NECAB2 Gene

  • N-Terminal EF-Hand Calcium Binding Protein 2 2 3 5
  • Synaptotagmin-Interacting Protein 2 3 4
  • Neuronal Calcium-Binding Protein 2 3 4
  • EF-Hand Calcium Binding Protein 2 2 3
  • EF-Hand Calcium-Binding Protein 2 3 4
  • Stip-2 3 4
  • EFCBP2 3 4
  • EF Hand Calcium Binding Protein 2 3
  • Neuronal Calcium Binding 2 3

External Ids for NECAB2 Gene

Previous HGNC Symbols for NECAB2 Gene

  • EFCBP2

Previous GeneCards Identifiers for NECAB2 Gene

  • GC16P083744
  • GC16P082560
  • GC16P069754

Summaries for NECAB2 Gene

GeneCards Summary for NECAB2 Gene

NECAB2 (N-Terminal EF-Hand Calcium Binding Protein 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB3.

Gene Wiki entry for NECAB2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAB2 Gene

Genomics for NECAB2 Gene

Regulatory Elements for NECAB2 Gene

Enhancers for NECAB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NECAB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NECAB2 Gene

Chromosome:
16
Start:
83,965,185 bp from pter
End:
84,002,776 bp from pter
Size:
37,592 bases
Orientation:
Plus strand

Genomic View for NECAB2 Gene

Genes around NECAB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECAB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECAB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECAB2 Gene

Proteins for NECAB2 Gene

  • Protein details for NECAB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6G3-NECA2_HUMAN
    Recommended name:
    N-terminal EF-hand calcium-binding protein 2
    Protein Accession:
    Q7Z6G3
    Secondary Accessions:
    • A2RRG3
    • O75547
    • Q6ZSK0

    Protein attributes for NECAB2 Gene

    Size:
    386 amino acids
    Molecular mass:
    43194 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI31616.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86948.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NECAB2 Gene

Proteomics data for NECAB2 Gene at MOPED

Post-translational modifications for NECAB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NECAB2 Gene

No data available for DME Specific Peptides for NECAB2 Gene

Domains & Families for NECAB2 Gene

Suggested Antigen Peptide Sequences for NECAB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6G3

UniProtKB/Swiss-Prot:

NECA2_HUMAN :
  • Contains 1 ABM domain.
Domain:
  • Contains 1 ABM domain.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with NECAB2: view

Function for NECAB2 Gene

Gene Ontology (GO) - Molecular Function for NECAB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with NECAB2: view
genes like me logo Genes that share phenotypes with NECAB2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NECAB2 Gene

Localization for NECAB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECAB2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NECAB2 Gene COMPARTMENTS Subcellular localization image for NECAB2 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NECAB2 Gene

Pathways & Interactions for NECAB2 Gene

SuperPathways for NECAB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NECAB2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NECAB2 Gene

Drugs & Compounds for NECAB2 Gene

No Compound Related Data Available

Transcripts for NECAB2 Gene

Unigene Clusters for NECAB2 Gene

N-terminal EF-hand calcium binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NECAB2 Gene

No ASD Table

Relevant External Links for NECAB2 Gene

GeneLoc Exon Structure for
NECAB2
ECgene alternative splicing isoforms for
NECAB2

Expression for NECAB2 Gene

mRNA expression in normal human tissues for NECAB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NECAB2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.9), Brain - Amygdala (x7.0), Brain - Caudate (basal ganglia) (x6.5), Brain - Putamen (basal ganglia) (x5.7), Brain - Anterior cingulate cortex (BA24) (x4.9), and Brain - Hypothalamus (x4.1).

Protein differential expression in normal tissues from HIPED for NECAB2 Gene

This gene is overexpressed in Fetal Brain (24.4), Brain (21.2), and Frontal cortex (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NECAB2 Gene



SOURCE GeneReport for Unigene cluster for NECAB2 Gene Hs.140950

mRNA Expression by UniProt/SwissProt for NECAB2 Gene

Q7Z6G3-NECA2_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expression patterns with NECAB2: view

Primer Products

No data available for Protein tissue co-expression partners for NECAB2 Gene

Orthologs for NECAB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECAB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NECAB2 35
  • 85.77 (n)
  • 85.77 (a)
NECAB2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NECAB2 35
  • 84.23 (n)
  • 83.33 (a)
mouse
(Mus musculus)
Mammalia Necab2 35
  • 83.68 (n)
  • 85.49 (a)
Necab2 16
Necab2 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NECAB2 35
  • 98.53 (n)
  • 98.45 (a)
NECAB2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Necab2 35
  • 81.85 (n)
  • 82.52 (a)
oppossum
(Monodelphis domestica)
Mammalia NECAB2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NECAB2 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves NECAB2 35
  • 71.87 (n)
  • 66.15 (a)
NECAB2 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NECAB2 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731915 35
  • 70.85 (n)
  • 69.85 (a)
zebrafish
(Danio rerio)
Actinopterygii necab2 35
  • 67.86 (n)
  • 66.82 (a)
necab2 36
  • 50 (a)
OneToOne
Species with no ortholog for NECAB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECAB2 Gene

ENSEMBL:
Gene Tree for NECAB2 (if available)
TreeFam:
Gene Tree for NECAB2 (if available)

Paralogs for NECAB2 Gene

Paralogs for NECAB2 Gene

(2) SIMAP similar genes for NECAB2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NECAB2: view

Variants for NECAB2 Gene

Sequence variations from dbSNP and Humsavar for NECAB2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs2292323 - 83,994,402(+) AACAA(A/G)GCAAG reference, missense
rs2292324 - 83,994,409(+) CAAGA(C/G)CCTTC reference, missense
rs2292329 - 83,998,279(+) CGCCA(C/G)TATCT reference, missense
rs2271298 - 84,001,841(+) GCCCC(C/G)TGTGT reference, missense
rs3880 -- 84,002,744(-) CTGGG(C/T)ACAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NECAB2 Gene

Variant ID Type Subtype PubMed ID
nsv517566 CNV Gain+Loss 19592680
nsv471106 CNV Gain 18288195
dgv2928n71 CNV Loss 21882294
nsv528396 CNV Loss 19592680
nsv907038 CNV Gain 21882294
nsv907040 CNV Loss 21882294
nsv457591 CNV Loss 19166990
dgv357n27 CNV Loss 19166990
nsv457594 CNV Loss 19166990
esv28321 CNV Loss 19812545
nsv827780 CNV Loss 20364138

Variation tolerance for NECAB2 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.05; 90.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NECAB2 Gene

Disorders for NECAB2 Gene

Relevant External Links for NECAB2

Genetic Association Database (GAD)
NECAB2
Human Genome Epidemiology (HuGE) Navigator
NECAB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NECAB2

No disorders were found for NECAB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NECAB2 Gene

Publications for NECAB2 Gene

  1. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PMID: 12044471) Sugita S. … Suedhof T.C. (Neuroscience 2002) 2 3 4 67
  2. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for NECAB2 Gene

Sources for NECAB2 Gene

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