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Aliases for NECAB1 Gene

Aliases for NECAB1 Gene

  • N-Terminal EF-Hand Calcium Binding Protein 1 2 3
  • Neuronal Calcium-Binding Protein 1 3 4
  • EF-Hand Calcium Binding Protein 1 2 3
  • EF-Hand Calcium-Binding Protein 1 3 4
  • EFCBP1 3 4
  • N-Terminal EF-Hand Calcium-Binding Protein 1 3
  • Synaptotagmin Interacting Protein 1 3
  • EF Hand Calcium Binding Protein 1 3
  • Neuronal Calcium Binding Protein 3
  • STIP-1 3

External Ids for NECAB1 Gene

Previous Symbols for NECAB1 Gene

  • EFCBP1

Summaries for NECAB1 Gene

GeneCards Summary for NECAB1 Gene

NECAB1 (N-Terminal EF-Hand Calcium Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAB1 Gene

Genomics for NECAB1 Gene

Genomic Location for NECAB1 Gene

90,791,550 bp from pter
90,959,408 bp from pter
167,859 bases
Plus strand

Genomic View for NECAB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NECAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECAB1 Gene

Regulatory Elements for NECAB1 Gene

Proteins for NECAB1 Gene

  • Protein details for NECAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-terminal EF-hand calcium-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6NUS7
    • Q96AZ7
    • Q9HBW8

    Protein attributes for NECAB1 Gene

    351 amino acids
    Molecular mass:
    40571 Da
    Quaternary structure:
    • Interacts with STX1 and CPNE6.

    Alternative splice isoforms for NECAB1 Gene


neXtProt entry for NECAB1 Gene

Proteomics data for NECAB1 Gene at MOPED

Post-translational modifications for NECAB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NECAB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NECAB1 Gene

Domains for NECAB1 Gene

Gene Families for NECAB1 Gene

  • EFHAND :EF-hand domain containing
  • NECAB :N-terminal EF-hand calcium binding proteins

Suggested Antigen Peptide Sequences for NECAB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ABM domain.:
    • Q8N987
  • Contains 2 EF-hand domains.:
    • Q8N987
genes like me logo Genes that share domains with NECAB1: view

Function for NECAB1 Gene

Gene Ontology (GO) - Molecular Function for NECAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with NECAB1: view

Phenotypes for NECAB1 Gene

GenomeRNAi human phenotypes for NECAB1:
genes like me logo Genes that share phenotypes with NECAB1: view

miRNA for NECAB1 Gene

miRTarBase miRNAs that target NECAB1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NECAB1 Gene

Localization for NECAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECAB1 Gene


Subcellular locations from

Jensen Localization Image for NECAB1 Gene COMPARTMENTS Subcellular localization image for NECAB1 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NECAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NECAB1: view

Pathways for NECAB1 Gene

SuperPathways for NECAB1 Gene

No Data Available

Interacting Proteins for NECAB1 Gene

Gene Ontology (GO) - Biological Process for NECAB1 Gene


No data available for Pathways by source for NECAB1 Gene

Compounds for NECAB1 Gene

(1) Novoseek inferred chemical compound relationships for NECAB1 Gene

Compound -log(P) Hits PubMed IDs
calcium 23.6 5
genes like me logo Genes that share compounds with NECAB1: view

Transcripts for NECAB1 Gene

Unigene Clusters for NECAB1 Gene

N-terminal EF-hand calcium binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NECAB1 Gene

No ASD Table

Relevant External Links for NECAB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NECAB1 Gene

mRNA expression in normal human tissues for NECAB1 Gene

mRNA differential expression in normal tissues according to GTEx for NECAB1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (8.3), Brain - Anterior cingulate cortex (BA24) (6.5), Brain - Spinal cord (cervical c-1) (6.1), Brain - Cortex (5.2), and Brain - Hippocampus (4.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NECAB1 Gene

SOURCE GeneReport for Unigene cluster for NECAB1 Gene Hs.719466

mRNA Expression by UniProt/SwissProt for NECAB1 Gene

Tissue specificity: Expressed in brain (at protein level).
genes like me logo Genes that share expressions with NECAB1: view

Orthologs for NECAB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECAB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NECAB1 35
  • 99.26 (n)
  • 99.68 (a)
  • 100 (a)
(Canis familiaris)
Mammalia NECAB1 35
  • 91.3 (n)
  • 94.72 (a)
  • 95 (a)
(Mus musculus)
Mammalia Necab1 35
  • 91.07 (n)
  • 96.58 (a)
Necab1 16
Necab1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia NECAB1 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia NECAB1 36
  • 57 (a)
(Rattus norvegicus)
Mammalia Necab1 35
  • 91.26 (n)
  • 96.3 (a)
(Gallus gallus)
Aves NECAB1 35
  • 78.56 (n)
  • 83.84 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia NECAB1 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia necab1 35
  • 76.93 (n)
  • 82.01 (a)
(Danio rerio)
Actinopterygii necab1 35
  • 70 (n)
  • 76.97 (a)
necab1 36
  • 72 (a)
Species with no ortholog for NECAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECAB1 Gene

Gene Tree for NECAB1 (if available)
Gene Tree for NECAB1 (if available)

Paralogs for NECAB1 Gene

Paralogs for NECAB1 Gene

Selected SIMAP similar genes for NECAB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NECAB1: view

Variants for NECAB1 Gene

Sequence variations from dbSNP and Humsavar for NECAB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs901382 -- 90,877,701(-) TGCAT(C/G)AGAAT intron-variant
rs931336 -- 90,933,760(-) AAGAC(C/T)GTGAA intron-variant
rs931337 -- 90,926,384(-) ATAAG(A/G)CTTTA intron-variant
rs937738 -- 90,849,870(-) TGATC(A/C)ACTAT intron-variant
rs937739 -- 90,849,534(-) CAACT(A/G)TAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NECAB1 Gene

Variant ID Type Subtype PubMed ID
nsv891185 CNV Loss 21882294
esv272269 CNV Insertion 20981092
esv269945 CNV Insertion 20981092

Relevant External Links for NECAB1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECAB1 Gene

Disorders for NECAB1 Gene

(1) Novoseek inferred disease relationships for NECAB1 Gene

Disease -log(P) Hits PubMed IDs
neurodegenerative diseases 28.2 2
genes like me logo Genes that share disorders with NECAB1: view

No data available for UniProtKB/Swiss-Prot for NECAB1 Gene

Publications for NECAB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PMID: 12044471) Sugita S. … Suedhof T.C. (Neuroscience 2002) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. EFCBP1/NECAB1, a brain-specifically expressed gene with highest abundance in temporal lobe, encodes a protein containing EF-hand and antibiotic biosynthesis monooxygenase domains. (PMID: 17364817) Wu H. … Yu L. (DNA Seq. 2007) 3

Products for NECAB1 Gene

Sources for NECAB1 Gene

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