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Aliases for NECAB1 Gene

Aliases for NECAB1 Gene

  • N-Terminal EF-Hand Calcium Binding Protein 1 2 3 5
  • Neuronal Calcium-Binding Protein 1 3 4
  • EF-Hand Calcium-Binding Protein 1 3 4
  • EFCBP1 3 4
  • N-Terminal EF-Hand Calcium-Binding Protein 1 3
  • Synaptotagmin Interacting Protein 1 3
  • EF-Hand Calcium Binding Protein 1 2
  • Neuronal Calcium Binding Protein 3
  • STIP-1 3

External Ids for NECAB1 Gene

Previous HGNC Symbols for NECAB1 Gene

  • EFCBP1

Previous GeneCards Identifiers for NECAB1 Gene

  • GC08P091873
  • GC08P087013

Summaries for NECAB1 Gene

GeneCards Summary for NECAB1 Gene

NECAB1 (N-Terminal EF-Hand Calcium Binding Protein 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NECAB1 Gene

Genomics for NECAB1 Gene

Regulatory Elements for NECAB1 Gene

Enhancers for NECAB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G090640 1.4 Ensembl ENCODE 10.4 -147.8 -147763 7.6 HDGF PKNOX1 CREB3L1 ARNT SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 TMEM64 NECAB1 LINC01030 ENSG00000254180 LOC102724670
GH08G090698 1 ENCODE dbSUPER 11.6 -91.1 -91073 3.0 NFIB JUN CEBPG ZNF316 NFE2 FOS MAFK NFE2L2 TCF7L2 CEBPB TMEM64 NECAB1 ENSG00000254182 LOC102724670
GH08G090692 1 ENCODE dbSUPER 10.7 -98.0 -98001 2.8 HDGF ESRRA JUN SIN3A RAD21 CTBP1 GATA3 FOSL2 FOS TCF7L2 TMEM64 NECAB1 ENSG00000254182 LOC102724670
GH08G090927 0.6 ENCODE 10.4 +136.4 136428 0.2 BCL11A SMARCA4 POU5F1 CUX1 CHD7 ETS1 TMEM64 NECAB1 LOC105375634 LOC105375635
GH08G090873 0.5 dbSUPER 10.9 +83.1 83059 1.4 PKNOX1 GATA3 RAD21 TCF7L2 NECAB1 TMEM64 LOC105375634 LOC105375635
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NECAB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NECAB1 Gene

90,791,550 bp from pter
90,959,408 bp from pter
167,859 bases
Plus strand

Genomic View for NECAB1 Gene

Genes around NECAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NECAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NECAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NECAB1 Gene

Proteins for NECAB1 Gene

  • Protein details for NECAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    N-terminal EF-hand calcium-binding protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6NUS7
    • Q96AZ7
    • Q9HBW8

    Protein attributes for NECAB1 Gene

    351 amino acids
    Molecular mass:
    40571 Da
    Quaternary structure:
    • Interacts with STX1 (PubMed:12044471). May interact with CPNE6 (PubMed:12044471).

    Alternative splice isoforms for NECAB1 Gene


neXtProt entry for NECAB1 Gene

Post-translational modifications for NECAB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NECAB1 Gene

No data available for DME Specific Peptides for NECAB1 Gene

Domains & Families for NECAB1 Gene

Suggested Antigen Peptide Sequences for NECAB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NECAB1: view

No data available for UniProtKB/Swiss-Prot for NECAB1 Gene

Function for NECAB1 Gene

Gene Ontology (GO) - Molecular Function for NECAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NECAB1: view

Phenotypes for NECAB1 Gene

genes like me logo Genes that share phenotypes with NECAB1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NECAB1 Gene

Localization for NECAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NECAB1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NECAB1 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NECAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NECAB1: view

Pathways & Interactions for NECAB1 Gene

SuperPathways for NECAB1 Gene

No Data Available

Interacting Proteins for NECAB1 Gene

Gene Ontology (GO) - Biological Process for NECAB1 Gene


No data available for Pathways by source and SIGNOR curated interactions for NECAB1 Gene

Drugs & Compounds for NECAB1 Gene

(1) Drugs for NECAB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NECAB1: view

Transcripts for NECAB1 Gene

Unigene Clusters for NECAB1 Gene

N-terminal EF-hand calcium binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NECAB1 Gene

No ASD Table

Relevant External Links for NECAB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NECAB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NECAB1 Gene

mRNA differential expression in normal tissues according to GTEx for NECAB1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x8.3), Brain - Anterior cingulate cortex (BA24) (x6.5), Brain - Spinal cord (cervical c-1) (x6.1), Brain - Cortex (x5.2), and Brain - Hippocampus (x4.0).

Protein differential expression in normal tissues from HIPED for NECAB1 Gene

This gene is overexpressed in Brain (33.6) and Frontal cortex (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NECAB1 Gene

Protein tissue co-expression partners for NECAB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NECAB1 Gene:


SOURCE GeneReport for Unigene cluster for NECAB1 Gene:


mRNA Expression by UniProt/SwissProt for NECAB1 Gene:

Tissue specificity: Expressed in brain (at protein level).

Evidence on tissue expression from TISSUES for NECAB1 Gene

  • Nervous system(4.9)
  • Kidney(4.3)
genes like me logo Genes that share expression patterns with NECAB1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NECAB1 Gene

Orthologs for NECAB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NECAB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NECAB1 34 35
  • 99.26 (n)
(Monodelphis domestica)
Mammalia NECAB1 35
  • 92 (a)
(Canis familiaris)
Mammalia NECAB1 34 35
  • 91.3 (n)
(Rattus norvegicus)
Mammalia Necab1 34
  • 91.26 (n)
(Mus musculus)
Mammalia Necab1 34 16 35
  • 91.07 (n)
(Ornithorhynchus anatinus)
Mammalia NECAB1 35
  • 57 (a)
(Gallus gallus)
Aves NECAB1 34 35
  • 78.56 (n)
(Anolis carolinensis)
Reptilia NECAB1 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia necab1 34
  • 76.93 (n)
(Danio rerio)
Actinopterygii necab1 34 35
  • 70 (n)
Species where no ortholog for NECAB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NECAB1 Gene

Gene Tree for NECAB1 (if available)
Gene Tree for NECAB1 (if available)

Paralogs for NECAB1 Gene

Paralogs for NECAB1 Gene

(3) SIMAP similar genes for NECAB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NECAB1: view

Variants for NECAB1 Gene

Sequence variations from dbSNP and Humsavar for NECAB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000041604 -- 90,804,238(+) GAATT(A/G)GAGAC intron-variant
rs1000101798 -- 90,946,990(+) CATGA(C/G)CCCCA intron-variant, nc-transcript-variant
rs1000102138 -- 90,895,251(+) CATAT(A/G)CTCCT intron-variant, nc-transcript-variant
rs1000125843 -- 90,837,128(+) GGTTC(A/C)AAAAA intron-variant
rs1000139746 -- 90,949,961(+) TTGTA(C/G)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NECAB1 Gene

Variant ID Type Subtype PubMed ID
esv3305668 CNV mobile element insertion 20981092
esv3307995 CNV mobile element insertion 20981092
esv3361095 CNV insertion 20981092
esv3375473 CNV insertion 20981092
nsv1028201 CNV loss 25217958

Variation tolerance for NECAB1 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NECAB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NECAB1 Gene

Disorders for NECAB1 Gene

Relevant External Links for NECAB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NECAB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NECAB1 Gene

Publications for NECAB1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PMID: 12044471) Sugita S. … Suedhof T.C. (Neuroscience 2002) 3 4 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64

Products for NECAB1 Gene

Sources for NECAB1 Gene

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