Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NECAB1 Gene

protein-coding   GIFtS: 44
GCID: GC08P091873

N-Terminal EF-Hand Calcium Binding Protein 1

(Previous name: EF-hand calcium binding protein 1)
(Previous symbol: EFCBP1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Terminal EF-Hand Calcium Binding Protein 11 2     STIP-12
EFCBP11 2 3     EF Hand Calcium Binding Protein 12
EF-Hand Calcium Binding Protein 11 2     N-Terminal EF-Hand Calcium-Binding Protein 12
Neuronal Calcium-Binding Protein 12 3     Neuronal Calcium Binding Protein2
EF-Hand Calcium-Binding Protein 12 3     Synaptotagmin Interacting Protein 12

External Ids:    HGNC: 209831   Entrez Gene: 641682   Ensembl: ENSG000001231197   UniProtKB: Q8N9873   

Export aliases for NECAB1 gene to outside databases

Previous GC identifer: GC08P087013


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NECAB1 Gene: 
NECAB1 (N-terminal EF-hand calcium binding protein 1) is a protein-coding gene. Diseases associated with NECAB1 include neuronitis, and motor neuron disease. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NECAB3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.2  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NECAB1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B2   oct-B3   HNF-1A   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNECAB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NECAB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NECAB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.3   Ensembl cytogenetic band:  8q21.3   HGNC cytogenetic band: 8q21.3

NECAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NECAB1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P091873:  view genomic region     (about GC identifiers)

Start:
91,803,778 bp from pter      End:
91,971,636 bp from pter
Size:
167,859 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NECA1_HUMAN, Q8N987 (See protein sequence)
Recommended Name: N-terminal EF-hand calcium-binding protein 1  
Size: 351 amino acids; 40571 Da
Subunit: Interacts with STX1 and CPNE6 (By similarity)
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q6NUS7 Q96AZ7 Q9HBW8
Alternative splicing: 2 isoforms:  Q8N987-1   Q8N987-2   

Explore the universe of human proteins at neXtProt for NECAB1: NX_Q8N987

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N987

  • NECAB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_071746.1  
    ENSEMBL proteins: 
     ENSP00000387380   ENSP00000428953   ENSP00000428632  

    Human Recombinant Protein Products for NECAB1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NECAB1
    OriGene Protein Over-expression Lysate for NECAB1
    OriGene MassSpec for NECAB1 
    OriGene Custom Protein Services for NECAB1
    GenScript Custom Purified and Recombinant Proteins Services for NECAB1
    Novus Biologicals NECAB1 Protein
    Novus Biologicals NECAB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NECAB1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    NECAB1 for ontologies           About GeneDecksing



    NECAB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NECAB1
    OriGene Custom Antibody Services for NECAB1
    GenScript Custom Superior Antibodies Services for NECAB1
    Novus Biologicals NECAB1 Antibodies
    Abcam antibodies for NECAB1
    Cloud-Clone Corp. Antibodies for NECAB1 
    Search ThermoFisher Antibodies for NECAB1
    LSBio Antibodies in human, mouse, rat for NECAB1 

    Assay Products for NECAB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NECAB1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NECAB1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NECAB1 
    Cloud-Clone Corp. CLIAs for NECAB1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NECAB: N-terminal EF-hand calcium binding proteins
    EFHAND: EF-hand domain containing

    5 InterPro protein domains:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR007138 Antibiotic_mOase
     IPR011008 Dimeric_a/b-barrel
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q8N987

    ProtoNet protein and cluster: Q8N987

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB007138 Antibiotic biosynthesis monooxygenase


    UniProtKB/Swiss-Prot: NECA1_HUMAN, Q8N987
    Similarity: Contains 1 ABM domain
    Similarity: Contains 2 EF-hand domains


    NECAB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    NECAB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NECAB1:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NECAB1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NECAB1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NECAB1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NECAB1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NECAB1
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate NECAB1 (see all 59):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-4328 hsa-miR-3616-5p hsa-miR-200a hsa-let-7a-2* hsa-miR-30d hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidNECAB1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NECAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NECAB1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NECAB1
    Sirion Biotech Customized adenovirus for overexpression of NECAB1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NECAB1 (see all 7)
    OriGene ORF clones in mouse, rat for NECAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NECAB1 (NM_022351)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NECAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NECAB1
    Sirion Biotech Customized lentivirus for stable overexpression of NECAB1 
                         Customized lentivirus expression plasmids for stable overexpression of NECAB1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NECAB1
    Search LifeMap BioReagents cell lines for NECAB1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAB1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NECAB1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NECAB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NECAB1 (NECA1)

    1 Novoseek inferred chemical compound relationship for NECAB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 23.6 5 2140897 (1), 12648752 (1), 15937283 (1), 11278424 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about NECAB1 / NECA1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NECAB1 gene: 
    NM_022351.4  

    Unigene Cluster for NECAB1:

    N-terminal EF-hand calcium binding protein 1
    Hs.719466  [show with all ESTs]
    Unigene Representative Sequence: AF414126
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417640(uc011lgg.2 uc003yer.3) ENST00000522729 ENST00000523962
    ENST00000521954 ENST00000522820 ENST00000521366

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NECAB1
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate NECAB1 (see all 59):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-4328 hsa-miR-3616-5p hsa-miR-200a hsa-let-7a-2* hsa-miR-30d hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmidNECAB1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NECAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NECAB1
    Clone
    Products:
         
    OriGene clones in human, mouse for NECAB1 (see all 7)
    OriGene ORF clones in mouse, rat for NECAB1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NECAB1 (NM_022351)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NECAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NECAB1
    Sirion Biotech Customized lentivirus for stable overexpression of NECAB1 
                         Customized lentivirus expression plasmids for stable overexpression of NECAB1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NECAB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NECAB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NECAB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NECAB1

    Additional mRNA sequence: 

    AF193756.1 AF414126.2 AK095533.1 AK098356.1 AY224210.1 BC016340.1 BC068448.1 

    13 DOTS entries:

    DT.97790248  DT.120634168  DT.91754654  DT.40127005  DT.99988831  DT.92424701  DT.97769042  DT.95085888 
    DT.120634233  DT.120634271  DT.95267220  DT.452582  DT.95166910 

    24/61 AceView cDNA sequences (see all 61):

    AV730822 AW275234 CD674256 NM_022351 AK098356 AW275210 AK095533 CA391663 
    BM547579 N53641 CA391662 AF414126 BX645427 AY224210 BU675075 BC016340 
    AI796710 BC068448 BP349805 BX952997 BE967495 BF952302 BG701847 BI553452 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NECAB1 expression in normal human tissues (normalized intensities)      NECAB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NECAB1 Expression
    About this image


    NECAB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             kidney ; cells in glomeruli   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    Genevestigator expression for NECAB1

    SOURCE GeneReport for Unigene cluster: Hs.719466

    UniProtKB/Swiss-Prot: NECA1_HUMAN, Q8N987
    Tissue specificity: Expressed in brain (at protein level)

        SABiosciences Custom PCR Arrays for NECAB1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NECAB1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NECAB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NECAB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NECAB1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NECAB1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Necab11 , 5 N-terminal EF-hand calcium binding protein 11, 5 91.07(n)1
    96.58(a)1
      4 (6.45 cM)5
    693521  NM_178617.41  NP_848732.31 
     149522455 
    chicken
    (Gallus gallus)
    Aves NECAB11 N-terminal EF-hand calcium binding protein 1 78.56(n)
    83.84(a)
      420219  XM_418329.3  XP_418329.1 
    lizard
    (Anolis carolinensis)
    Reptilia NECAB16
    N-terminal EF-hand calcium binding protein 1
    75(a)
    1 ↔ 1
    4(21118966-21167592)
    zebrafish
    (Danio rerio)
    Actinopterygii necab11 N-terminal EF-hand calcium binding protein 1 69.93(n)
    76.26(a)
      550546  NM_001017848.1  NP_001017848.1 


    ENSEMBL Gene Tree for NECAB1 (if available)
    TreeFam Gene Tree for NECAB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NECAB1 gene
    NECAB32  NECAB22  
    3 SIMAP similar genes for NECAB1 using alignment to 1 protein entry:     NECA1_HUMAN:
    NECAB2    NECAB3    APBA2BP

    NECAB1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3063 SNPs in NECAB1 are shown (see all 3063)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1411631261,2
    --91801952(+) TTGCAA/GGCTTC 1 -- us2k10--------
    rs1899820431,2
    --91801962(+) CCTCAC/TTGACA 1 -- us2k10--------
    rs1828002231,2
    --91801983(+) TGAGGC/TTGGGA 1 -- us2k10--------
    rs1881565641,2
    --91802014(+) GCTATA/TCCTGT 1 -- us2k10--------
    rs777610451,2
    C,F--91802067(+) CCTCAA/GAGCAT 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1503149871,2
    C--91802092(+) GAAAAA/GCTTCC 1 -- us2k10--------
    rs1928186021,2
    --91802096(+) AACTTA/CCTATA 1 -- us2k10--------
    rs791774841,2
    F--91802102(+) CTATAC/TGGAAG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1379754681,2
    C--91802265(+) TCTATA/CGGAAG 1 -- us2k10--------
    rs1127799811,2
    C--91802360(+) TTTTTT/-GTAAG 1 -- us2k11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for NECAB1 (91803778 - 91971636 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NECAB1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv269945CNV Insertion20981092
    esv272269CNV Insertion20981092
    nsv891185CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NECAB1
    DNA2.0 Custom Variant and Variant Library Synthesis for NECAB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for NECAB1:    About MalaCards
    neuronitis    motor neuron disease    schizophrenia    alzheimer's disease


    NECAB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for NECAB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 28.2 2 2140897 (1), 8232749 (1)


    Export disorders for NECAB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NECAB1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NECAB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern. (PubMed id 12044471)1, 2 Sugita S.... Suedhof T.C. (2002)
    4. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    5. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    6. EFCBP1/NECAB1, a brain-specifically expressed gene wi th highest abundance in temporal lobe, encodes a protein containing EF-hand and antibiotic biosynthesis monooxygenase domains. (PubMed id 17364817)1 Wu H....Yu L. (2007)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
    9. Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein. (PubMed id 15937283)9 Venkitaramani D.V....Johansen J. (2005)
    10. Neuronal calcium-binding proteins and schizophrenia. (PubMed id 12165373)9 Eyles D.W....Reynolds G.P. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64168 HGNC: 20983 AceView: EFCBP1 Ensembl:ENSG00000123119 euGenes: HUgn64168
    ECgene: NECAB1 H-InvDB: NECAB1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NECAB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NECAB1 gene:
    Search GeneIP for patents involving NECAB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NECAB1   OriGene RNAi products in human, mouse, rat for NECAB1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for NECAB1  
     OriGene MassSpec something-or-other for NECAB1   OriGene clones in human, mouse for NECAB1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NECAB1   OriGene Purified Protein for NECAB1  
     OriGene ORF clones in mouse, rat for NECAB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NECAB1   OriGene Custom Protein Services for NECAB1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NECAB1
     QIAGEN SeqTarget long-range PCR primers for resequencing NECAB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NECAB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NECAB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NECAB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NECAB1
     GenScript Custom Purified and Recombinant Proteins Services for NECAB1 GenScript cDNA clones with any tag delivered in your preferred vector for NECAB1
     GenScript Custom Assay Services for NECAB1 GenScript Custom Superior Antibodies Services for NECAB1
     GenScript Custom overexpressing Cell Line Services for NECAB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NECAB1 promoter
     Search Chromatin IP Primers for NECAB1
     RT2 qPCR Primer Assay in human, mouse, rat NECAB1
     Search GNC Networks for NECAB1
     SABiosciences Custom PCR Arrays for NECAB1
     Search Tocris compounds for NECAB1 (NECA1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NECAB1 antibodies
     NECAB1 proteins
     NECAB1 lysates
     Antibodies for NECAB1
     See all of Abcam's Antibodies, Kits and Proteins for NECAB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NECAB1
     Antibodies for NECAB1
     ELISAs for NECAB1
     CLIAs for NECAB1
     Search LifeMap BioReagents cell lines for NECAB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NECAB1
     SwitchGear 3'UTR luciferase reporter plasmids for NECAB1
     SwitchGear Promoter luciferase reporter plasmids for NECAB1
     Search ThermoFisher Antibodies for NECAB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NECAB1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NECAB1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NECAB1
    Customized:
     lentivirus for stable overexpression of NECAB1
     lentivirus expression plasmids for stable overexpression of NECAB1
     adenovirus for overexpression of NECAB1
     LSBio Antibodies in human, mouse, rat for NECAB1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NECAB1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4