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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NEBL Gene

protein-coding GIFtS: 54
GCID: GC10M021110

nebulette

Explore 7 diseases affiliated with
NEBL via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Nebulette¹
Actin-Binding Z-Disk Protein² ³
LNEBL² ³
LASP2²
LIM-Nebulette¹

External Ids:	HGNC: 16932¹	Entrez Gene: 10529²	Ensembl: ENSG00000078114⁷	OMIM: 605491⁵	UniProtKB: O76041³

Export aliases for NEBL gene to outside databases

Previous GC identifers: GC10M020805 GC10M021220 GC10M021074

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEBL:

This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds

actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be

involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in

non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple

transcript variants. (provided by RefSeq, Mar 2010)

UniProtKB/Swiss-Prot: NEBL_HUMAN, O76041

Function: Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the

assembly of focal adhesion

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_008705.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NEBL gene promoter:
TBP SRF STAT5B SRF (504 AA) POU6F1 (c2) SRY FOXO4 Cart-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NEBL promoter sequence

Search SABiosciences Chromatin IP Primers for NEBL

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NEBL

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p12 Ensembl cytogenetic band: 10p12.31 HGNC cytogenetic band: 10p12

NEBL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEBL gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M021110: view genomic region (about GC identifiers)

Start:	21,068,902 bp from pter	End:	21,463,116 bp from pter
Size:	394,215 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEBL_HUMAN, O76041 (See protein sequence)

Recommended Name: Nebulette

Size: 1014 amino acids; 116453 Da

Subunit: Isoform 2 interacts with ZYX (Zyxin)

Subcellular location: Isoform 2: Cytoplasm

1 PDB 3D structure from and Proteopedia for NEBL:

4F14 (3D)

Secondary accessions: B0YJ45 Q2TBD0 Q70I54 Q9UIC4

Alternative splicing: 2 isoforms: O76041-1 O76041-2 (Expressed in non-muscle cells. May be transcribed from an upstream promoter active in non-muscle cells)

Explore the universe of human proteins at neXtProt for NEBL: NX_O76041

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O76041

NEBL Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001166955.1 NP_006384.1 NP_998734.1

ENSEMBL proteins:

ENSP00000366326 ENSP00000393896 ENSP00000366323 ENSP00000396512 ENSP00000366364

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	Uscn Proteins for NEBL

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	IDA	10470015
GO:0030018	Z disc	IDA	10470015
GO:0031674	I band	NAS	9733644

NEBL for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for NEBL

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NEBL for domains About GeneDecksing

2 InterPro domains/families:

IPR000900 Nebulin_35r-motif

IPR001452 SH3_domain

Graphical View of Domain Structure for InterPro Entry O76041

ProtoNet protein and cluster: O76041

1 Blocks protein family: IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: NEBL_HUMAN, O76041

Similarity: Contains 23 nebulin repeats

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NEBL_HUMAN, O76041

Function: Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the

assembly of focal adhesion

miRNA Products:		OriGene 3'-UTR Clone (see all 2): NEBL Browse MicroRNA Expression Plasmids
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		8/70 QIAGEN miScript miRNA Assays for microRNAs that regulate NEBL (see all 70):
		hsa-miR-3678-3p hsa-miR-361-5p hsa-miR-15a hsa-miR-128 hsa-miR-3653 hsa-miR-3916 hsa-miR-1243 hsa-miR-3148

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NEBL

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11309420
GO:0005523	tropomyosin binding	IPI	17987659
GO:0008092	cytoskeletal protein binding	IPI	17987659
GO:0008307	structural constituent of muscle	NAS	9733644
GO:0031005	filamin binding	IPI	17987659

NEBL for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NEBL

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/9 Interacting proteins for NEBL (O76041^{2, 3} ENSP00000366326⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 9)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MED28	Q9H204²^,³, ENSP00000237380⁴	MINT-7041896 I2D: score=1 STRING: ENSP00000237380
TRIM63	Q969Q1²^,³, ENSP00000363390⁴	MINT-6503420 I2D: score=1 STRING: ENSP00000363390
SMURF2	Q9HAU4²^,³, ENSP00000262435⁴	MINT-6503750 I2D: score=1 STRING: ENSP00000262435
MYPN	Q86TC9³, ENSP00000351790⁴	I2D: score=2 STRING: ENSP00000351790
ZYX	Q15942³, ENSP00000324422⁴	I2D: score=2 STRING: ENSP00000324422

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0071691	cardiac muscle thin filament assembly	IMP	11822876

NEBL for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NEBL
Search CenterWatch for drugs/clinical trials and news about NEBL

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NEBL gene (4 alternative transcripts):

NM_001173484.1 NM_006393.2 NM_213569.2 NM_016365.1

Unigene Cluster for NEBL:

Nebulette

Hs.5025 [show with all ESTs]

Unigene Representative Sequence: NM_006393

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377122(uc001iqi.3 uc001iqj.3 uc001iqk.3 uc021pnu.1)

ENST00000417816 ENST00000493005 ENST00000492325 ENST00000473616 ENST00000481592

ENST00000460652 ENST00000498424 ENST00000482754 ENST00000377119 ENST00000434381

ENST00000485750 ENST00000464278 ENST00000377159

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		hsa-miR-3678-3p hsa-miR-361-5p hsa-miR-15a hsa-miR-128 hsa-miR-3653 hsa-miR-3916 hsa-miR-1243 hsa-miR-3148

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Additional cDNA sequence:

AB209311.1 AJ580772.1 AK096540.1 AK294926.1 AK295186.1 AK316521.1 BC110452.1 BC110453.1

BC126132.1 BC126134.1 BC144201.1 Y16241.1 Y17673.1

17 DOTS entries:

DT.100716190 DT.40306380 DT.121293235 DT.121293153 DT.100031782 DT.95151100 DT.97834609 DT.97864036

DT.97898337 DT.121293127 DT.121293129 DT.121293222 DT.121293240 DT.40129341 DT.95188120 DT.436616

DT.97790455

24/209 AceView cDNA sequences (see all 209):

AA514316 BM717843 AA385261 AJ580772 BX953237 AL599233 T20218 AA917863

AI868640 CF552513 AA461473 AA907393 BG623611 N47664 AI244978 CA503280

AI005062 AW192323 BM971081 AA976864 AA236882 AI431418 AI364095 BI522541

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for NEBL About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	^	20	^	21	^	22	^
SP1:
SP2:
SP3:									-		-						-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP4:
SP5:									-

ExUns:	23	^	24	^	25a	·	25b	^	26	^	27	^	28	^	29	^	30a	·	30b	^	31	^	32	^	33
SP1:							-
SP2:
SP3:	-		-		-		-		-		-		-				-		-		-
SP4:
SP5:

ECgene alternative splicing isoforms for NEBL

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NEBL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTGAAACT

About this image

NEBL expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Amacrine, Retina

Epicardium

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NEBL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NEBL

SOURCE GeneReport for Unigene cluster: Hs.5025

UniProtKB/Swiss-Prot: NEBL_HUMAN, O76041

Tissue specificity: Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines

in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 is expressed in non-muscle cells such as in

fibroblasts

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NEBL gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	Q766Y2_CHICK⁶	nebulette non-muscle isoform	57(a)	1 ↔ 1	2(18040904-18285246)
lizard (Anolis carolinensis)	Reptilia	NEBL⁶	--	67(a)	1 ↔ 1	6(16881303-16926315)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12109²	Xenopus laevis transcribed sequence with weak similarity more	77.53(n)		BI851040.1
zebrafish (Danio rerio)	Actinopterygii	nebl⁶	nebulette	44(a)	1 ↔ 1	2(20873367-20878695)
fruit fly (Drosophila melanogaster)	Insecta	Lasp⁶	Lasp	13(a)	1 → many	3L(16669506-16704777)
worm (Caenorhabditis elegans)	Secernentea	F42H10.3⁶	LIM and SH3 domain protein F42H10.3	23(a)	1 → many	III(8484081-8488284)

ENSEMBL Gene Tree for NEBL (if available)
TreeFam Gene Tree for NEBL (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NEBL gene

NRAP² LASP1² NEB²

5 SIMAP similar genes for NEBL using alignment to 6 protein entries: NEBL_HUMAN (see all proteins):

SH3GL2 ARHGEF7 ITSN1 NEB LASP1

NEBL for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for NEBL
PGOHUM00000240212

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs61392565^1,2	F,	--	20732090(+)	`TGGATT/CATGGA`	3	--	ds500¹		1		EA	120
rs76077902^1,2	F,	--	20732514(+)	`GATTCA/GTAATA`	3	--	ds500¹		1		EA	120
rs77932198^1,2	F,	--	20732636(+)	`AATTAG/CGAAGG`	3	--	ut3¹		1		WA	118
rs41277358^1,2		--	20732976(+)	`GTTGCA/GGTACT`	3	--	ut3¹		0	--	--	--	--
rs45454397^1,2	C,	--	20733286(+)	`AGATAG/TGAAAT`	3	--	ut3¹		1		NS	38
rs12358829^1,2	H	--	20733927(+)	`CATCAA/TCCACA`	3	--	ut3¹ ese³		4		NS EA	420
rs11012338^1,2	C,F,H,	--	20734065(+)	`TCATTG/ACATGG`	3	--	ut3¹		21		NS EA NA	2198
rs76654330^1,2	F,	--	20734287(+)	`GTAGTC/GTAAGC`	3	--	ut3¹		1		EA	120
rs35422327^1,2	C,F,	--	20734355(+)	`GTTGAC/TAGTTA`	3	--	ut3¹		4		NA	126
rs16921055^1,2	C,F,H,	--	20734657(+)	`TCTATA/GTAAAT`	3	--	ut3¹ ese³		11		NA NS EA WA	1350

HapMap Linkage Disequilibrium report for NEBL (21068902 - 21318902 bp, first 250kb of NEBL)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NEBL
1 Indel: 100888
Human Gene Mutation Database (HGMD): NEBL

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NEBL

DNA2.0 Custom Variant and Variant Library Synthesis for NEBL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NEBL for disorders           About GeneDecksing

OMIM gene information: 605491    OMIM disorders: --

7 diseases for NEBL:    About MalaCards

endocardial fibroelastosis tricuspid valve insufficiency dilated cardiomyopathy cardiomyopathy

parkinson's disease alzheimer's disease leukemia

2 diseases from the University of Copenhagen DISEASES database for NEBL:

Endocardial fibroelastosis Ebstein anomaly

Genetic Association Database (GAD): NEBL
Human Genome Epidemiology (HuGE) Navigator: NEBL (4 documents)

Export disorders for NEBL gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NEBL gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with NEBL)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of the human nebulette gene: a polymorphism in an actin-binding motif is associated with nonfamilial idiopathic dilated cardiomyopathy. (PubMed id 11140941)^{1, 2, 4, 9} Arimura T....Kimura A. (2000)
Functional dissection of nebulette demonstrates actin binding of nebulin-like repeats and Z-line targeting of SH3 and linker domains. (PubMed id 10470015)^{1, 2, 3} Moncman C.L. and Wang K. (1999)
Characterization of nebulette and nebulin and emerging concepts of their roles for vertebrate Z-discs. (PubMed id 9733644)^{1, 2, 3} Millevoi S.... Labeit S. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. (PubMed id 15004028)^{1, 2} Li B.... Trueb B. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Identification and characterization of LASP2 gene in silico. (PubMed id 12883659)^{1, 9} Katoh M. and Katoh M. (2003)
Nebulette mutations are associated with dilated cardi omyopathy and endocardial fibroelastosis. (PubMed id 20951326)¹ Purevjav E....Towbin J.A. (2010)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10529	HGNC: 16932	AceView: NEBL	Ensembl:ENSG00000078114	euGenes: HUgn10529
ECgene: NEBL	H-InvDB: NEBL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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PharmGKB entry for NEBL	Pharmacogenomics, SNPs, Pathways

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Patent Information for NEBL gene:
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