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Aliases for NDUFV3 Gene

Aliases for NDUFV3 Gene

  • NADH Dehydrogenase (Ubiquinone) Flavoprotein 3, 10kDa 2 3
  • NADH-Ubiquinone Oxidoreductase 9 KDa Subunit 3 4
  • Renal Carcinoma Antigen NY-REN-4 3 4
  • Complex I 10kDa Subunit 2 3
  • Complex I-9kD 3 4
  • CI-9KD 3 4
  • NADH Dehydrogenase [Ubiquinone] Flavoprotein 3, Mitochondrial 3
  • Complex I, Mitochondrial Respiratory Chain, 10-KD Subunit 3
  • NADH Dehydrogenase (Ubiquinone) Flavoprotein 3 (10kD) 2
  • NADH-Ubiquinone Oxidoreductase Flavoprotein 3, 10kD 3
  • Mitochondrial NADH Oxidoreductase-Like Protein 3
  • NADH-Ubiquinone Oxidoreductase 9 KD Subunit 3
  • CI-10k 3

External Ids for NDUFV3 Gene

Previous GeneCards Identifiers for NDUFV3 Gene

  • GC21P040847
  • GC21P043194
  • GC21P043193
  • GC21P043172
  • GC21P044299

Summaries for NDUFV3 Gene

Entrez Gene Summary for NDUFV3 Gene

  • The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NDUFV3 Gene

NDUFV3 (NADH Dehydrogenase (Ubiquinone) Flavoprotein 3, 10kDa) is a Protein Coding gene. Diseases associated with NDUFV3 include autosomal recessive nonsyndromic deafness. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFV3 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFV3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFV3 Gene

Genomics for NDUFV3 Gene

Regulatory Elements for NDUFV3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDUFV3 Gene

Start:
42,879,644 bp from pter
End:
42,913,304 bp from pter
Size:
33,661 bases
Orientation:
Plus strand

Genomic View for NDUFV3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFV3 Gene

Proteins for NDUFV3 Gene

  • Protein details for NDUFV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56181-NDUV3_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
    Protein Accession:
    P56181
    Secondary Accessions:
    • A8K0M1
    • J3KNX7
    • Q6FGD3
    • Q8WU60
    • Q9HCR5

    Protein attributes for NDUFV3 Gene

    Size:
    108 amino acids
    Molecular mass:
    11941 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

    Alternative splice isoforms for NDUFV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFV3 Gene

Proteomics data for NDUFV3 Gene at MOPED

Post-translational modifications for NDUFV3 Gene

  • Ubiquitination at Lys127
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFV3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFV3 Gene

Domains for NDUFV3 Gene

Gene Families for NDUFV3 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFV3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFV3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56181

UniProtKB/Swiss-Prot:

NDUV3_HUMAN :
  • P56181
Family:
  • Belongs to the complex I NDUFV3 subunit family.
genes like me logo Genes that share domains with NDUFV3: view

Function for NDUFV3 Gene

Molecular function for NDUFV3 Gene

GENATLAS Biochemistry: NADH ubiquinone dehydrogenase (Q reductase),component of the complex I multi-subunit of the phosphorylation (OXPHOS),flavoprotein 3,inner mitochondrial membrane,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NDUFV3: view

Animal Model Products

CRISPR Products

miRNA for NDUFV3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFV3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFV3 Gene

Localization for NDUFV3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFV3 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFV3 Gene COMPARTMENTS Subcellular localization image for NDUFV3 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for NDUFV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
genes like me logo Genes that share ontologies with NDUFV3: view

Pathways for NDUFV3 Gene

genes like me logo Genes that share pathways with NDUFV3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for NDUFV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFV3: view

Compounds for NDUFV3 Gene

(8) HMDB Compounds for NDUFV3 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFV3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFV3: view

Transcripts for NDUFV3 Gene

Unigene Clusters for NDUFV3 Gene

NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFV3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFV3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2: - - - -
SP3:
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for NDUFV3 Gene

GeneLoc Exon Structure for
NDUFV3
ECgene alternative splicing isoforms for
NDUFV3

Expression for NDUFV3 Gene

mRNA expression in normal human tissues for NDUFV3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFV3 Gene

This gene is overexpressed in Muscle - Skeletal (4.1) and Heart - Left Ventricle (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFV3 Gene

SOURCE GeneReport for Unigene cluster for NDUFV3 Gene Hs.473937

genes like me logo Genes that share expressions with NDUFV3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NDUFV3 Gene

Orthologs for NDUFV3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFV3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFV3 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFV3 36
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFV3 35
  • 71.56 (n)
  • 58.72 (a)
NDUFV3 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufv3 35
  • 65.87 (n)
  • 52.06 (a)
Ndufv3 16
Ndufv3 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFV3 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFV3 36
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufv3 35
  • 64.96 (n)
  • 52.46 (a)
chicken
(Gallus gallus)
Aves NDUFV3 36
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ndufv3 36
  • 45 (a)
OneToMany
ndufv3 36
  • 21 (a)
OneToMany
wufl83h06 35
Species with no ortholog for NDUFV3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFV3 Gene

ENSEMBL:
Gene Tree for NDUFV3 (if available)
TreeFam:
Gene Tree for NDUFV3 (if available)

Paralogs for NDUFV3 Gene

No data available for Paralogs for NDUFV3 Gene

Variants for NDUFV3 Gene

Sequence variations from dbSNP and Humsavar for NDUFV3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs10595 -- 42,904,255(-) GTCGT(C/T)CCCTG intron-variant, missense, reference
rs1041452 -- 42,896,176(+) TTTTG(C/T)GACAG intron-variant
rs1316879 -- 42,892,487(+) GAATC(A/G)CTAGC upstream-variant-2KB
rs1573472 -- 42,892,688(+) TGGGG(A/G)CGAAC upstream-variant-2KB
rs2008193 -- 42,896,001(+) TTTTT(C/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFV3 Gene

Variant ID Type Subtype PubMed ID
esv2666871 CNV Deletion 23128226
nsv913812 CNV Gain 21882294
nsv913820 CNV Gain 21882294
nsv834105 CNV Loss 17160897
esv2652948 CNV Insertion 19546169
esv1340851 CNV Insertion 17803354
esv1737156 CNV Insertion 17803354
nsv187067 CNV Insertion 16902084

Relevant External Links for NDUFV3 Gene

HapMap Linkage Disequilibrium report
NDUFV3
Human Gene Mutation Database (HGMD)
NDUFV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFV3 Gene

Disorders for NDUFV3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NDUFV3 Gene including...

Search for NDUFV3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NDUFV3 Gene

Relevant External Links for NDUFV3

Genetic Association Database (GAD)
NDUFV3
Human Genome Epidemiology (HuGE) Navigator
NDUFV3
genes like me logo Genes that share disorders with NDUFV3: view

No data available for UniProtKB/Swiss-Prot for NDUFV3 Gene

Publications for NDUFV3 Gene

  1. Molecular cloning and characterization of the human mitochondrial NADH:oxidoreductase 10-kDa gene (NDUFV3). (PMID: 9344673) de Coo R.F.M. … van Oost B.A. (Genomics 1997) 2 3 4 23
  2. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 3 4
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  4. Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region. (PMID: 10950923) Berry A. … Bonne-Tamir B. (Genomics 2000) 3 4
  5. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4

Products for NDUFV3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDUFV3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFV3
    • Block miRNA regulation of NDUFV3 using miScript Target Protectors

    Sources for NDUFV3 Gene

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