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Aliases for NDUFV3 Gene

Aliases for NDUFV3 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit V3 2 3 5
  • NADH Dehydrogenase (Ubiquinone) Flavoprotein 3, 10kDa 2 3
  • NADH-Ubiquinone Oxidoreductase 9 KDa Subunit 3 4
  • Renal Carcinoma Antigen NY-REN-4 3 4
  • Complex I 10kDa Subunit 2 3
  • Complex I-9kD 3 4
  • CI-9KD 3 4
  • Complex I, Mitochondrial Respiratory Chain, 10-KD Subunit 3
  • NADH Dehydrogenase (Ubiquinone) Flavoprotein 3 (10kD) 2
  • NADH-Ubiquinone Oxidoreductase Flavoprotein 3, 10kD 3
  • Mitochondrial NADH Oxidoreductase-Like Protein 3
  • NADH-Ubiquinone Oxidoreductase 9 KD Subunit 3
  • CI-10k 3

External Ids for NDUFV3 Gene

Previous GeneCards Identifiers for NDUFV3 Gene

  • GC21P040847
  • GC21P043194
  • GC21P043193
  • GC21P043172
  • GC21P044299

Summaries for NDUFV3 Gene

Entrez Gene Summary for NDUFV3 Gene

  • The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for NDUFV3 Gene

NDUFV3 (NADH:Ubiquinone Oxidoreductase Subunit V3) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include poly(A) RNA binding and NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFV3 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFV3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFV3 Gene

Genomics for NDUFV3 Gene

Regulatory Elements for NDUFV3 Gene

Enhancers for NDUFV3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NDUFV3 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFV3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDUFV3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDUFV3 Gene

Chromosome:
21
Start:
42,879,644 bp from pter
End:
42,913,304 bp from pter
Size:
33,661 bases
Orientation:
Plus strand

Genomic View for NDUFV3 Gene

Genes around NDUFV3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFV3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFV3 Gene

Proteins for NDUFV3 Gene

  • Protein details for NDUFV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56181-NDUV3_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
    Protein Accession:
    P56181
    Secondary Accessions:
    • A8K0M1
    • J3KNX7
    • Q6FGD3
    • Q8WU60
    • Q9HCR5

    Protein attributes for NDUFV3 Gene

    Size:
    108 amino acids
    Molecular mass:
    11941 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.

    Alternative splice isoforms for NDUFV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFV3 Gene

Proteomics data for NDUFV3 Gene at MOPED

Post-translational modifications for NDUFV3 Gene

  • Ubiquitination at Lys 127
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFV3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFV3 Gene

Domains & Families for NDUFV3 Gene

Protein Domains for NDUFV3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFV3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56181

UniProtKB/Swiss-Prot:

NDUV3_HUMAN :
  • Belongs to the complex I NDUFV3 subunit family.
Family:
  • Belongs to the complex I NDUFV3 subunit family.
genes like me logo Genes that share domains with NDUFV3: view

Function for NDUFV3 Gene

Molecular function for NDUFV3 Gene

GENATLAS Biochemistry:
NADH ubiquinone dehydrogenase (Q reductase),component of the complex I multi-subunit of the phosphorylation (OXPHOS),flavoprotein 3,inner mitochondrial membrane,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NDUFV3: view
genes like me logo Genes that share phenotypes with NDUFV3: view

Animal Model Products

CRISPR Products

miRNA for NDUFV3 Gene

miRTarBase miRNAs that target NDUFV3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFV3 Gene

Localization for NDUFV3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFV3 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFV3 Gene COMPARTMENTS Subcellular localization image for NDUFV3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NDUFV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NDUFV3: view

Pathways & Interactions for NDUFV3 Gene

genes like me logo Genes that share pathways with NDUFV3: view

Gene Ontology (GO) - Biological Process for NDUFV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
genes like me logo Genes that share ontologies with NDUFV3: view

No data available for SIGNOR curated interactions for NDUFV3 Gene

Drugs & Compounds for NDUFV3 Gene

(1) Drugs for NDUFV3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra Target 0
genes like me logo Genes that share compounds with NDUFV3: view

Transcripts for NDUFV3 Gene

Unigene Clusters for NDUFV3 Gene

NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFV3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2: - - - -
SP3:
SP4: - -
SP5: - - - - -
SP6:

Relevant External Links for NDUFV3 Gene

GeneLoc Exon Structure for
NDUFV3
ECgene alternative splicing isoforms for
NDUFV3

Expression for NDUFV3 Gene

mRNA expression in normal human tissues for NDUFV3 Gene

mRNA differential expression in normal tissues according to GTEx for NDUFV3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1) and Heart - Left Ventricle (x4.0).

Protein differential expression in normal tissues from HIPED for NDUFV3 Gene

This gene is overexpressed in Heart (23.1) and Fetal Brain (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFV3 Gene



SOURCE GeneReport for Unigene cluster for NDUFV3 Gene Hs.473937

genes like me logo Genes that share expression patterns with NDUFV3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NDUFV3 Gene

Orthologs for NDUFV3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFV3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NDUFV3 35
  • 71.56 (n)
  • 58.72 (a)
NDUFV3 36
  • 53 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufv3 35
  • 65.87 (n)
  • 52.06 (a)
Ndufv3 16
Ndufv3 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufv3 35
  • 64.96 (n)
  • 52.46 (a)
cow
(Bos Taurus)
Mammalia NDUFV3 36
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFV3 36
  • 36 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFV3 36
  • 36 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDUFV3 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFV3 36
  • 26 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii wufl83h06 35
ndufv3 36
  • 45 (a)
OneToMany
ndufv3 36
  • 21 (a)
OneToMany
Species with no ortholog for NDUFV3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFV3 Gene

ENSEMBL:
Gene Tree for NDUFV3 (if available)
TreeFam:
Gene Tree for NDUFV3 (if available)

Paralogs for NDUFV3 Gene

No data available for Paralogs for NDUFV3 Gene

Variants for NDUFV3 Gene

Sequence variations from dbSNP and Humsavar for NDUFV3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1316879 -- 42,892,487(+) GAATC(A/G)CTAGC upstream-variant-2KB
rs1573472 -- 42,892,688(+) TGGGG(A/G)CGAAC upstream-variant-2KB
rs4920006 -- 42,894,765(+) TTTCT(A/G)TCAGC intron-variant
rs4920007 -- 42,907,552(+) ttcaa(A/G)caatt intron-variant
rs4920008 -- 42,907,873(+) GGCGT(A/G)AGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFV3 Gene

Variant ID Type Subtype PubMed ID
esv2666871 CNV Deletion 23128226
nsv913812 CNV Gain 21882294
nsv913820 CNV Gain 21882294
nsv834105 CNV Loss 17160897
esv2652948 CNV Insertion 19546169
esv1340851 CNV Insertion 17803354
esv1737156 CNV Insertion 17803354
nsv187067 CNV Insertion 16902084

Variation tolerance for NDUFV3 Gene

Residual Variation Intolerance Score: 44.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.11; 69.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFV3 Gene

Human Gene Mutation Database (HGMD)
NDUFV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFV3 Gene

Disorders for NDUFV3 Gene

Relevant External Links for NDUFV3

Genetic Association Database (GAD)
NDUFV3
Human Genome Epidemiology (HuGE) Navigator
NDUFV3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFV3

No disorders were found for NDUFV3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFV3 Gene

Publications for NDUFV3 Gene

  1. Molecular cloning and characterization of the human mitochondrial NADH:oxidoreductase 10-kDa gene (NDUFV3). (PMID: 9344673) de Coo R.F.M. … van Oost B.A. (Genomics 1997) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for NDUFV3 Gene

Sources for NDUFV3 Gene

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