Aliases for NDUFS8 Gene
- NADH Dehydrogenase (Ubiquinone) Fe-S Protein 8, 23kDa (NADH-Coenzyme Q Reductase) 2 3
- NADH-Ubiquinone Oxidoreductase 23 KDa Subunit 3 4
- Complex I 23kDa Subunit 2 3
- Complex I-23kD 3 4
- NADH Dehydrogenase (Ubiquinone) Fe-S Protein 8 (23kD) (NADH-Coenzyme Q Reductase) 2
- NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 8, Mitochondrial 3
- NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 8 2
- Mitochondrial 2
- TYKY Subunit 4
External Ids for NDUFS8 Gene
This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010]
GeneCards Summary for NDUFS8 Gene
NDUFS8 (NADH Dehydrogenase (Ubiquinone) Fe-S Protein 8, 23kDa (NADH-Coenzyme Q Reductase)) is a Protein Coding gene. Diseases associated with NDUFS8 include leigh syndrome and leigh syndrome with leukodystrophy. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and 4 iron, 4 sulfur cluster binding.
UniProtKB/Swiss-Prot for NDUFS8 Gene
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone.