NDUFS8 Gene
protein-coding GIFtS: 62
GCID: GC11P067798
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NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme...(Previous name: NADH dehydrogenase (ubiquinone) Fe-S protein 8 (23kD) (NADH-coenzyme...)
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Aliases
for NDUFS8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NADH Dehydrogenase (Ubiquinone) Fe-S Protein 8, 23kDa (NADH-Coenzyme QReductase)1 2 | | Complex I 23kDa Subunit2 | | CI-23k1 2 | | NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 8, Mitochondrial2 | | TYKY1 2 | | CI-23kD3 | | Complex I-23kD2 3 | | EC 1.6.5.33 | | NADH-Ubiquinone Oxidoreductase 23 KDa Subunit2 3 | | EC 1.6.99.33 | | NADH Dehydrogenase (Ubiquinone) Fe-S Protein 8 (23kD) (NADH-Coenzyme QReductase)1 | | TYKY Subunit3 | | CI23KD2 | | EC 1.6.99.58 |
Export aliases for NDUFS8 gene to outside databasesPrevious GC identifers: GC11P070321 GC11P069494 GC11P068048 GC11P067573 GC11P067554 GC11P064133 |
Summaries
for NDUFS8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NDUFS8:
This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of therespiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria.The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, assuch, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome.(provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: NDUS8_HUMAN, O00217Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believedto belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADHto the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).May donate electrons to ubiquinone
Gene Wiki entry for NDUFS8
|
Genomic Views
for NDUFS8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDUFS8 gene promoter:
NF-1 NF-1/L AP-1 p53 Fra-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFS8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFS8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.2NDUFS8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P067798: view genomic region
(about GC identifiers)
Start:
|
67,798,084 bp from pter |
End:
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67,804,114 bp from pter |
Size:
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6,031 bases |
Orientation:
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plus strand |
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Proteins
for NDUFS8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NDUS8_HUMAN, O00217 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial precursor Size: 210 amino acids; 23705 Da
Cofactor: Binds 2 4Fe-4S clusters per subunit (By similarity)
Subunit: Mammalian complex I is composed of 45 different subunits
Subcellular location: Mitochondrion (Probable)
Secondary accessions: B2RB86 Q0VDA8Explore the universe of human proteins at neXtProt for NDUFS8: NX_O00217
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00217
2 DME Specific Peptides for NDUFS8 (O00217)
NDUFS8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002487.1
ENSEMBL proteins: ENSP00000315774 ENSP00000403972 ENSP00000433645 ENSP00000432848 ENSP00000433054 ENSP00000436287 ENSP00000433521 ENSP00000432968 ENSP00000431293 ENSP00000434283 Reactome Protein details: O00217
Human Recombinant Protein Products for NDUFS8:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NDUFS8 for ontologies About GeneDecksing
NDUFS8 Antibody Products:
Assay Products for NDUFS8: |
Protein
Domains /
Families
for NDUFS8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NDUFS8 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00217ProtoNet protein and cluster: O00217 UniProtKB/Swiss-Prot: NDUS8_HUMAN, O00217Similarity: Belongs to the complex I 23 kDa subunit familySimilarity: Contains 2 4Fe-4S ferredoxin-type domains |
Function
for NDUFS8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NDUS8_HUMAN, O00217Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believedto belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADHto the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).May donate electrons to ubiquinoneCatalytic activity: NADH + ubiquinone = NAD(+) + ubiquinolCatalytic activity: NADH + acceptor = NAD(+) + reduced acceptor Genatlas biochemistry entry for NDUFS8:NADH ubiquinone oxidoreductase (Q reductase),23kDa,component of the complex I multi-subunit enzyme of the oxidativephosphorylation (OXPHOS),iron-sulfur protein 8,inner mitochondrial membrane,TYKY subunit required for proper assemblyof complex I
Enzyme Numbers (IUBMB): EC 1.6.99.31 EC 1.6.99.52 EC 1.6.5.31
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
NDUFS8 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFS8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFS8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NDUFS8 (NM_002496) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDUFS8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFS8 |
|
Pathways & Interactions
for NDUFS8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NDUFS8
4 
Reactome Pathways for NDUFS8
5 
Kegg Pathways (Kegg details for NDUFS8):
NDUFS8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFS8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/284 Interacting proteins for NDUFS8 (O002172, 3 ENSP000003157744) via UniProtKB, MINT, STRING, and/or I2D (see all 284)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
NDUFS8 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDUFS8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NDUFS8 for compounds About GeneDecksing
 Browse Tocris compounds for NDUFS8
9 HMDB Compounds for NDUFS8 About this table
1 DrugBank Compound for NDUFS8 About this table
1 Novoseek chemical compound relationship for NDUFS8 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| iron-sulfur |
58.5 |
4 |
9837812 (1) |
Search CenterWatch for drugs/clinical trials and news about NDUFS8 / NDUS8
|
Transcripts
for NDUFS8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NDUFS8 gene: NM_002496.3 Unigene Cluster for NDUFS8: NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) Hs.90443 [show with all ESTs]Unigene Representative Sequence: AK00211015 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432321(uc010rpz.2) ENST00000313468(uc001onc.3 uc009ysb.2)
ENST00000531796 ENST00000453471 ENST00000526446 ENST00000528492 ENST00000532399
ENST00000531228 ENST00000526339 ENST00000525419 ENST00000525628 ENST00000529645
ENST00000524810 ENST00000526542 ENST00000531282
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFS8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFS8
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NDUFS8 (NM_002496) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDUFS8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFS8 |
Additional cDNA sequence: AK002110.1 AK223114.1 AK314546.1 BC119753.1 BC119754.2 U65579.1 13 DOTS entries: DT.214409 DT.100825467 DT.97859647 DT.120721261 DT.92440796 DT.92440792 DT.97859650 DT.100038006 DT.120721254 DT.97859648 DT.100038004 DT.100825466 DT.40118197 24/277 AceView cDNA sequences (see all 277): AA297392 BI769307 BU736847 BI822168 BE264899 BM694349 BM856145 BG327849 BQ009225 AW467286 CB138816 BM704859 CA393093 BG033269 D45735 BG747133 BQ067572 BM692994 BM767442 BQ635958 CB119284 BM563611 BM706204 AA584703
GeneLoc Exon Structure
5/16 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFS8 (see all 16) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | - | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | - | | - | | | | | |
| ExUns: | 12a | · | 12b | · | 12c | · | 12d |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for NDUFS8
|
Expression
for NDUFS8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDUFS8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGAGCTGCT
About this image
See NDUFS8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDUFS8
SOURCE GeneReport for Unigene cluster: Hs.90443
SABiosciences Expression via Pathway-Focused PCR Array including NDUFS8:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFS8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFS8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFS8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFS8 |
Orthologs
for NDUFS8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for NDUFS8 gene from 10/38 species (see all 38) About this table
ENSEMBL Gene Tree for NDUFS8 (if available)
TreeFam Gene Tree for NDUFS8 (if available) |
Paralogs
for NDUFS8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NDUFS8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NDUFS8 (67798084 - 67804114 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for NDUFS8
6 CNVs: 2931 29914 3856 53160 30558 29913
Human Gene Mutation Database (HGMD): NDUFS8
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFS8 |
|
Disorders
/ Diseases
for NDUFS8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDUFS8 for disorders About GeneDecksing
OMIM gene information: 602141
OMIM disorders: 256000
UniProtKB/Swiss-Prot: NDUS8_HUMAN, O00217
Defects in NDUFS8 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disordercharacterized by bilaterally symmetrical necrotic lesions in subcortical brain regions
10  diseases for NDUFS8: About MalaCardsmitochondrial complex i deficiency tumors of adrenal cortex leigh disease encephalomyopathy
adrenocortical carcinoma huntington's disease parkinson's disease tuberculosis
carcinoma mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for NDUFS8:Leigh disease 1 Novoseek disease relationship for NDUFS8 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leigh syndrome |
89.2 |
1 |
15159508 (1) |
Human Genome Epidemiology (HuGE) Navigator: NDUFS8 (5 documents)
Export disorders for NDUFS8 gene to outside databases
|
Publications
for NDUFS8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NDUFS8 gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with NDUFS8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The first nuclear-encoded complex I mutation in a patient with Leigh syndrome. (PubMed id 9837812)1, 2, 7, 9 Loeffen J.... van den Heuvel L. (1998)
- Genomic structure of the human NDUFS8 gene coding for the iron-sulfur TYKY subunit of the mitochondrial NADH:ubiquinone oxidoreductase. (PubMed id 9666055)1, 2, 3, 9 de Sury R.... Issartel J.-P. (1998)
- cDNA sequence and chromosomal localization of the NDUFS8 human gene coding for the 23 kDa subunit of the mitochondrial complex I. (PubMed id 9116042)1, 2, 3, 9 Procaccio V....Issartel J.P. (1997)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
- In situ hybridisation mapping of genomic clones for five human respiratory chain complex I genes. (PubMed id 9345899)1, 9 Dunbar D.R....Brookes A.J. (1997)
- Late-onset Leigh syndrome in a patient with mitochondrial complex I NDUFS8 mutations. (PubMed id 15159508)1, 9 Procaccio V. and Wallace D.C. (2004)
- YY1 and Sp1 activate transcription of the human NDUFS8 gene encoding the mitochondrial complex I TYKY subunit. (PubMed id 11955626)1, 9 Lescuyer P....Lunardi J. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
|
External Searches for NDUFS8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDUFS8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFS8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFS8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NDUFS8 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NDUFS8 |
|
| | |
About This Section
| Patent Information for NDUFS8 gene:
Search GeneIP for patents involving NDUFS8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDUFS8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
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| | |  | OriGene Antibodies for NDUFS8 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NDUFS8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFS8 | | | OriGene Protein Over-expression Lysate for NDUFS8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NDUFS8 | | OriGene 3'-UTR Clone for NDUFS8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFS8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFS8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NDUFS8 | | OriGene Custom Protein Services for NDUFS8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFS8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFS8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFS8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFS8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFS8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFS8 |
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| | | | Search Tocris compounds for NDUFS8 |
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 | | | NDUFS8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibody for NDUFS8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFS8 |
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