Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NDUFS7 Gene

protein-coding   GIFtS: 68
GCID: GC19P001384

NADH Dehydrogenase (Ubiquinone) Fe-S Protein 7, 20kDa (NADH-Coenzyme...

(Previous name: NADH dehydrogenase (ubiquinone) Fe-S protein 7 (20kD) (NADH-coenzyme...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NADH Dehydrogenase (Ubiquinone) Fe-S Protein 7, 20kDa (NADH-Coenzyme Q
Reductase)1 2
     CI-20KD2
Complex I 20kDa Subunit1 2     MY0172
Complex I-20kD2 3     Complex I, Mitochondrial Respiratory Chain, 20-KD Subunit2
NADH-Ubiquinone Oxidoreductase 20 KDa Subunit2 3     NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 7, Mitochondrial2
PSST Subunit2 3     NADH-Coenzyme Q Reductase2
PSST2 5     NADH:Ubiquinone Oxidoreductase PSST Subunit2
mitochondrial1     CI-20kD3
NADH Dehydrogenase (Ubiquinone) Fe-S Protein 7 (20kD) (NADH-Coenzyme Q
Reductase)1
     EC 1.6.5.33
NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 71     EC 1.6.99.33
CI-202     EC 1.6.99.58

External Ids:    HGNC: 77141   Entrez Gene: 3742912   Ensembl: ENSG000001152867   OMIM: 6018255   UniProtKB: O752513   
ORGUL members:         

Export aliases for NDUFS7 gene to outside databases

Previous GC identifers: GC19P001441 GC19P001453 GC19P001323 GC19P001334 GC19P001158


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NDUFS7 Gene:
This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory
chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide
(NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the
respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in
this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that
results in bilaterally symmetrical necrotic lesions in subcortical brain regions. (provided by RefSeq, Jul 2008)

GeneCards Summary for NDUFS7 Gene:
NDUFS7 (NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)) is a protein-coding gene. Diseases associated with NDUFS7 include decubitus ulcer, and leigh disease. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and protease binding.

UniProtKB/Swiss-Prot: NDUS7_HUMAN, O75251
Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
ubiquinone (By similarity)

Gene Wiki entry for NDUFS7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFS7 gene promoter:
         SRF   GCNF   SRF (504 AA)   STAT5A   Evi-1   RORalpha1   COMP1   GCNF-1   c-Myb   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFS7 promoter sequence
   Search Chromatin IP Primers for NDUFS7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFS7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13

NDUFS7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFS7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001384:  view genomic region     (about GC identifiers)

Start:
1,383,526 bp from pter      End:
1,395,588 bp from pter
Size:
12,063 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NDUS7_HUMAN, O75251 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor  
Size: 213 amino acids; 23564 Da
Cofactor: Binds 1 4Fe-4S cluster (Potential)
Subunit: Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of
the enzyme
Sequence caution: Sequence=AAC27669.1; Type=Erroneous gene model prediction;
Secondary accessions: Q2T9H7 Q9BV17

Explore the universe of human proteins at neXtProt for NDUFS7: NX_O75251

Explore proteomics data for NDUFS7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys129
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NDUFS7 (O75251) (see all 6)
     FRASPRQ  YGILQLQ  RASPRQSD  RYDMDRFG 


    See NDUFS7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_077718.3  
    ENSEMBL proteins: 
     ENSP00000440348   ENSP00000233627   ENSP00000443273   ENSP00000442822   ENSP00000467094  
     ENSP00000406630   ENSP00000364262  
    Reactome Protein details: O75251

    NDUFS7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NDUFS7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NDUFS7
    GenScript Custom Purified and Recombinant Proteins Services for NDUFS7
    Novus Biologicals NDUFS7 Proteins
    Novus Biologicals NDUFS7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NDUFS7

    NDUFS7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NDUFS7
    OriGene Custom Antibody Services for NDUFS7
    Novus Biologicals NDUFS7 Antibodies
    Abcam antibodies for NDUFS7
    Cloud-Clone Corp. Antibodies for NDUFS7
    ThermoFisher Antibodies for NDUFS7
    LSBio Antibodies in human, mouse, rat for NDUFS7

    NDUFS7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NDUFS7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NDUFS7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NDUFS7
    Cloud-Clone Corp. CLIAs for NDUFS7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    2 InterPro protein domains:
     IPR006137 NADH_UbQ_OxRdtase-like_20kDa
     IPR006138 NADH_UQ_OxRdtase_20Kd_su

    Graphical View of Domain Structure for InterPro Entry O75251

    ProtoNet protein and cluster: O75251

    1 Blocks protein domain: IPB006138 NADH dehydrogenase (ubiquinone)

    UniProtKB/Swiss-Prot: NDUS7_HUMAN, O75251
    Similarity: Belongs to the complex I 20 kDa subunit family


    NDUFS7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUS7_HUMAN, O75251
    Function: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is
    believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of
    electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be
    ubiquinone (By similarity)
    Catalytic activity: NADH + ubiquinone + 5 H(+)(In) = NAD(+) + ubiquinol + 4 H(+)(Out)
    Catalytic activity: NADH + acceptor = NAD(+) + reduced acceptor

         Genatlas biochemistry entry for NDUFS7:
    NADH ubiquinone dehydrogenase (Q reductase),20kDa,component of the complex I multi-subunit enzyme of the oxidative
    phosphorylation (OXPHOS),iron-sulfur protein 7,inner mitochondrial membrane

         Enzyme Numbers (IUBMB): EC 1.6.99.31 EC 1.6.99.52 EC 1.6.5.31

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0003954contributes to NADH dehydrogenase activity IMP14749350
    GO:0005515protein binding IPI15186778
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
    GO:0016655oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NAS8938450
         
    NDUFS7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFS7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NDUFS7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDUFS7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDUFS7

    miRNA
    Products:
        
    miRTarBase miRNAs that target NDUFS7:
    hsa-mir-125b-2-3p (MIRT038633), hsa-mir-455-3p (MIRT037906), hsa-mir-26b-5p (MIRT028986)

    Block miRNA regulation of human, mouse, rat NDUFS7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NDUFS7
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NDUFS7
    Predesigned siRNA for gene silencing in human, mouse, rat NDUFS7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NDUFS7

    Clone
    Products:
         
    OriGene clones in human, mouse for NDUFS7 (see all 7)
    OriGene ORF clones in mouse, rat for NDUFS7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDUFS7 (NM_024407)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFS7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFS7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NDUFS7
    Browse ESI BIO Cell Lines and PureStem Progenitors for NDUFS7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFS7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NDUS7_HUMAN, O75251: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0043005neuron projection IEA--
    GO:0043025neuronal cell body IEA--

    NDUFS7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NDUFS7 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway, Pharmacokinetics0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFS7
        Oxidative phosphorylation
    Electron Transport Chain

    1 Reactome Pathway for NDUFS7
        Respiratory electron transport

    1 PharmGKB Pathway for NDUFS7
        Doxorubicin Pathway, Pharmacokinetics

    Selected Kegg Pathways  (Kegg details for NDUFS7) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFS7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFS7: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFS7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFS7 (O752512, 3 ENSP000002336274) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    NDUFS5O439202, ENSP000003620584MINT-4981243 STRING: ENSP00000362058
    NDUFS3O754892, ENSP000002637744MINT-4981243 STRING: ENSP00000263774
    NDUFA9Q167952, ENSP000002665444MINT-4981243 STRING: ENSP00000266544
    ARRB2P321213, ENSP000002692604I2D: score=3 STRING: ENSP00000269260
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS8938450
    GO:0022904respiratory electron transport chain TAS--
    GO:0032981mitochondrial respiratory chain complex I assembly IMP11112787
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFS7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFS7 (NDUS7)

    9 HMDB Compounds for NDUFS7    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinol 8ubiquinol-8 (see all 2)56275-39-9--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    2 DrugBank Compounds for NDUFS7    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--10097178 8369340 17139284 17016423 8938450
    DoxorubicinAdria (see all 4)23214-92-8enzyme--9618942 12688675 2850270



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NDUFS7 gene: 
    NM_024407.4  

    Unigene Cluster for NDUFS7:

    NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
    Hs.211914  [show with all ESTs]
    Unigene Representative Sequence: AK126693
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546283 ENST00000233627(uc002lse.4) ENST00000545446(uc002lsf.2 uc002lsh.3 uc002lsg.2)
    ENST00000543289 ENST00000538662 ENST00000539480 ENST00000436115 ENST00000534853
    ENST00000546172 ENST00000414651 ENST00000538929 ENST00000538523 ENST00000540530
    ENST00000535382 ENST00000539882 ENST00000591358 ENST00000313408

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NDUFS7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NDUFS7
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NDUFS7
    Predesigned siRNA for gene silencing in human, mouse, rat NDUFS7
    Clone
    Products:
         
    OriGene clones in human, mouse for NDUFS7 (see all 7)
    OriGene ORF clones in mouse, rat for NDUFS7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDUFS7 (NM_024407)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFS7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFS7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NDUFS7
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFS7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDUFS7
      QuantiTect SYBR Green Assays in human, mouse, rat NDUFS7
      QuantiFast Probe-based Assays in human, mouse, rat NDUFS7

    Additional mRNA sequence: 

    AF060512.1 AF115969.1 AK126693.1 AK222738.1 AK289671.1 AK293917.1 AK297611.1 BC001715.3 
    BC005954.1 BC111517.1 

    22 DOTS entries:

    DT.431325  DT.100771857  DT.100843991  DT.91990051  DT.100028319  DT.100028321  DT.100771858  DT.101977992 
    DT.121495060  DT.121495091  DT.97846053  DT.40130128  DT.121495115  DT.95334843  DT.100028320  DT.121495027 
    DT.121495087  DT.95345908  DT.95334816  DT.95334836  DT.91880317  DT.99935520 

    Selected AceView cDNA sequences (see all 182):

    AJ572667 BQ640199 AA315377 AK127759 BM701138 BM797486 AK091623 AK092169 
    AI015529 AK128713 AJ572988 AK056061 CB110188 BM272658 CR606524 AK091046 
    BU845781 AW245467 AX747389 CR615407 AX746748 AX747100 BQ958676 BM835183 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDUFS7 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11
    SP1:                    -           -     -                 -                 -                       -     -               
    SP2:                    -           -     -                 -                 -                       -     -     -         
    SP3:                    -           -     -                 -                 -                                             
    SP4:                                -     -                 -                 -                       -                     
    SP5:                    -           -     -           -     -     -           -                                             


    ECgene alternative splicing isoforms for NDUFS7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NDUFS7 expression in normal human tissues (normalized intensities)      NDUFS7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAGCTGCG
    NDUFS7 Expression
    About this image


    NDUFS7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Heart (Cardiovascular System)
    NDUFS7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFS7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.211914
        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFS7: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NDUFS7
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFS7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDUFS7
    QuantiTect SYBR Green Assays in human, mouse, rat NDUFS7
    QuantiFast Probe-based Assays in human, mouse, rat NDUFS7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFS7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NDUFS7 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufs71 , 5 NADH dehydrogenase (ubiquinone) Fe-S protein 71, 5 82.22(n)1
    88.1(a)1
      10 (39.72 cM)5
    754061  NM_029272.31  NP_083548.11 
     802491215 
    chicken
    (Gallus gallus)
    Aves NDUFS71 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa more 80.07(n)
    86.96(a)
      770724  XM_001234053.3  XP_001234054.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.137172 Xenopus laevis transcribed sequence with moderate similarity more 76.72(n)    BJ084184.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj19d102 Danio rerio cDNA clone IMAGE6792046, containing frame-shift more 78.47(n)    BC056291.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG20143
    CG91721
    NADH dehydrogenase (ubiquinone)3
    CG91721
    83(a)
    (best of 2)3
    73.17(n)1
    81.13(a)1
      99B23
    325651  NM_167476.21  NP_727921.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W10D5.23
    nduf-71
    NADH-ubiquinone oxidoreductase 20 KD
    subunit3
    nduf-71
    68(a)3
    64.57(n)1
    76.73(a)1
      I(9116497-9118666)3
    1727341  NM_060044.41  NP_492445.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G117701 AT5G11770 64.56(n)
    69.47(a)
      831049  NM_121215.3  NP_196738.1 
    rice
    (Oryza sativa)
    Liliopsida Os.418382 Oryza sativa (japonica cultivar-group) putative NADH more 77.85(n)    NM_191797.1 


    ENSEMBL Gene Tree for NDUFS7 (if available)
    TreeFam Gene Tree for NDUFS7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NDUFS7 gene
    Selected SIMAP similar genes for NDUFS7 using alignment to 6 protein entries:     NDUS7_HUMAN (see all proteins) (see all similar genes):
    MTX2    ZNF23    CNOT2    IPO7    CCPG1    LRTOMT
    SENP7    C15orf40    ECD    QTRT1    ZNF568    ZNF738
    ATL2    NSD1    ZNHIT3    PSD3    KLHDC1    BUB1B

    NDUFS7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NDUFS7 (see all 414)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0088484
    Mitochondrial complex I deficiency (MT-C1D)4--see VAR_0088482 V M mis40--------
    rs1048947051,2
    Cpathogenic11319562(+) TGATCA/GTGGCC 2 M V mis10--------
    rs1499450511,2
    C--1162775(+) GGGGG-/TGGGGG 1 -- int10--------
    rs608968221,2
    C,F--1162790(+) GGGGGG/AGCGCC 1 -- int12Minor allele frequency- A:0.42WA NA 238
    rs1389822191,2
    C--1166341(+) TTTTC-/TTTTTTT 1 -- int10--------
    rs792078841,2
    C,F--1310396(+) AACTCT/CAAATT 1 -- us2k12Minor allele frequency- C:0.14CSA WA 119
    rs1117923671,2
    C,F--1310488(+) AGGCCA/GAGGTG 1 -- us2k11Minor allele frequency- G:0.00CSA 1
    rs1912321441,2
    --1310519(+) GAGTTC/GGAGAC 1 -- us2k10--------
    rs1160276771,2
    F--1310584(+) CGTAGT/CGTGTG 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1448741111,2
    C--1310719(+) TCAAA-/AAAT  
            
    AAATA
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NDUFS7 (1383526 - 1395588 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NDUFS7 (see all 24):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3589n71CNV Loss21882294
    nsv910292CNV Loss21882294
    nsv910499CNV Loss21882294
    nsv910489CNV Loss21882294
    dgv3595n71CNV Loss21882294
    dgv3555n71CNV Loss21882294
    dgv3575n71CNV Loss21882294
    nsv910494CNV Loss21882294
    dgv3597n71CNV Loss21882294
    dgv3596n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): NDUFS7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFS7
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFS7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601825   
    OMIM disorders: 256000  
    UniProtKB/Swiss-Prot: NDUS7_HUMAN, O75251
  • Leigh syndrome (LS) [MIM:256000]: An early-onset progressive neurodegenerative disorder characterized by
    the presence of focal, bilateral lesions in one or more areas of the central nervous system including the
    brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the
    central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia,
    weakness, vision loss, eye movement abnormalities, seizures, and dysphagia. Note=The disease is caused by
    mutations affecting the gene represented in this entry
  • Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory
    chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset
    neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific
    encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and
    some forms of Parkinson disease. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • Selected diseases for NDUFS7 (see all 22):    About MalaCards
    decubitus ulcer    leigh disease    mitochondrial dna deletion syndromes    leigh syndrome with leukodystrophy
    mitochondrial dna-associated leigh syndrome and narp    mitochondrial complex i deficiency    leber hereditary optic neuropathy    mitochondrial disorders
    leukodystrophy    huntington's disease    fatty liver disease    neuropathy
    myopathy    parkinson's disease    liver disease    tuberculosis
    alzheimer's disease    malaria    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for NDUFS7:
    Leigh disease

    NDUFS7 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NDUFS7
    Human Genome Epidemiology (HuGE) Navigator: NDUFS7 (3 documents)

    Export disorders for NDUFS7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NDUFS7 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with NDUFS7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Assignment of the PSST subunit gene of human mitochondrial complex I to chromosome 19p13. (PubMed id 8938450)1, 2, 3, 7, 9 Hyslop S.J.... Robinson B.H. (Genomics 1996)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    5. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    6. Leigh syndrome associated with a mutation in the NDUFS7 (PSST) nuclear encoded subunit of complex I. (PubMed id 10360771)1, 2 Triepels R.H.... Smeitink J.A.M. (Ann. Neurol. 1999)
    7. Human mitochondrial complex I in health and disease. (PubMed id 10330338)1, 2 Smeitink J. and van den Heuvel L. (Am. J. Hum. Genet. 1999)
    8. Mitigation of NADH: ubiquinone oxidoreductase deficiency by chronic Trolox treatment. (PubMed id 18435906)1, 9 Koopman W.J....Willems P.H. (Biochim. Biophys. Acta 2008)
    9. No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese. (PubMed id 22935918)1 Ma L....Chen X. (Psychiatr. Genet. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 374291 HGNC: 7714 AceView: NDUFS7 Ensembl:ENSG00000115286 euGenes: HUgn374291
    ECgene: NDUFS7 Kegg: 374291 H-InvDB: NDUFS7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NDUFS7 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=NDUFS7[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NDUFS7 gene:
    Search GeneIP for patents involving NDUFS7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NDUFS7   OriGene RNAi products in human, mouse, rat for NDUFS7  
     OriGene qPCR primer pairs and template standards for NDUFS7   OriGene Protein Over-expression Lysate for NDUFS7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NDUFS7  
     OriGene qSTAR qPCR primer pairs in human, mouse for NDUFS7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NDUFS7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NDUFS7   OriGene Custom Protein Services for NDUFS7  

     
     
     Block miRNA regulation of human, mouse, rat NDUFS7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NDUFS7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFS7 Predesigned siRNA for gene silencing in human, mouse, rat NDUFS7
     QuantiFast Probe-based Assays in human, mouse, rat NDUFS7 QuantiTect SYBR Green Assays in human, mouse, rat NDUFS7
     PCR Arrays including human, mouse, rat NDUFS7 Search Chromatin IP Primers for NDUFS7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDUFS7  Search GeneGlobe Interaction Network for NDUFS7
     Regulatory tfbs in NDUFS7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NDUFS7 GenScript cDNA clones with any tag delivered in your preferred vector for NDUFS7
     GenScript Custom Assay Services for NDUFS7 GenScript Custom overexpressing Cell Line Services for NDUFS7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NDUFS7 (NDUS7)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NDUFS7 antibodies
     NDUFS7 proteins
     NDUFS7 lysates
     Antibodies for NDUFS7
     See all of Abcam's Antibodies, Kits and Proteins for NDUFS7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NDUFS7
     Antibodies for NDUFS7
     ELISAs for NDUFS7
     CLIAs for NDUFS7



     Browse ESI BIO Cell Lines and PureStem Progenitors for NDUFS7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFS7
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NDUFS7
     SwitchGear Promoter luciferase reporter plasmids for NDUFS7
     ThermoFisher Antibodies for NDUFS7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFS7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFS7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NDUFS7
     LSBio Antibodies in human, mouse, rat for NDUFS7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NDUFS7 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4