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NDUFS6 Gene

protein-coding   GIFtS: 62
GCID: GC05P001801

NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6, 13kDa (NADH-Coenzyme...

(Previous name: NADH dehydrogenase (ubiquinone) Fe-S protein 6 (13kD) (NADH-coenzyme...)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6, 13kDa (NADH-Coenzyme Q
Reductase)1 2
     CI-13kA2
Complex I 13kDa Subunit A1 2     CI13KDA2
CI-13kD-A2 3     Complex I, Mitochondrial Respiratory Chain, 13-KD Subunit2
NADH-Ubiquinone Oxidoreductase 13 KDa-A Subunit2 3     NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 6, Mitochondrial2
mitochondrial1     NADH:Ubiquinone Oxidoreductase NDUFS6 Subunit2
NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6 (13kD) (NADH-Coenzyme Q
Reductase)1
     Complex I-13kD-A3
NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 61     

External Ids:    HGNC: 77131   Entrez Gene: 47262   Ensembl: ENSG000001454947   OMIM: 6038485   UniProtKB: O753803   

Export aliases for NDUFS6 gene to outside databases

Previous GC identifers: GC05P001942 GC05P001834 GC05P001854


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDUFS6 Gene:
This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex
in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to
the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein
fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety
of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.(provided by
RefSeq, Oct 2009)

GeneCards Summary for NDUFS6 Gene:
NDUFS6 (NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)) is a protein-coding gene. Diseases associated with NDUFS6 include mitochondrial complex i deficiency, and lactic acidosis. GO annotations related to this gene include electron carrier activity and NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NDUS6_HUMAN, O75380
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFS6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFS6 gene promoter:
         ER-alpha   RFX1   Pax-2   Nkx2-5   MIF-1   Pax-2a   GATA-1   MEF-2A   c-Myb   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFS6 promoter sequence
   Search Chromatin IP Primers for NDUFS6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

NDUFS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFS6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P001801:  view genomic region     (about GC identifiers)

Start:
1,801,496 bp from pter      End:
1,816,719 bp from pter
Size:
15,224 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NDUS6_HUMAN, O75380 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor  
Size: 124 amino acids; 13712 Da
Subunit: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP)
fragment of the enzyme

Explore the universe of human proteins at neXtProt for NDUFS6: NX_O75380

Explore proteomics data for NDUFS6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NDUFS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004544.1  
    ENSEMBL proteins: 
     ENSP00000274137   ENSP00000422557  
    Reactome Protein details: O75380

    NDUFS6 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    2 InterPro protein domains:
     IPR019401 Znf_CHCC
     IPR016668 NADH_Ub_cplx-1_Fe-S_6_mit

    Graphical View of Domain Structure for InterPro Entry O75380

    ProtoNet protein and cluster: O75380

    UniProtKB/Swiss-Prot: NDUS6_HUMAN, O75380
    Similarity: Belongs to the complex I NDUFS6 subunit family


    NDUFS6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUS6_HUMAN, O75380
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Genatlas biochemistry entry for NDUFS6:
    NADH ubiquinone oxidoreductase (Q reductase),13kDa,component of the complex I multi-subunit enzyme of the
    oxidative phosphorylation (OXPHOS),iron-sulfur protein 6,inner mitochondrial membrane

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9647766
    GO:0009055electron carrier activity NAS9647766
         
    NDUFS6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NDUFS6:
     Decreased viability with pacli 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ndufs6):
     cardiovascular system  cellular  growth/size/body  homeostasis/metabolism  mortality/aging 
     muscle  reproductive system 

    NDUFS6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFS6
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDUFS6
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    miRNA
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    miRTarBase miRNAs that target NDUFS6:
    hsa-mir-193b-3p (MIRT041397), hsa-mir-27b-3p (MIRT046190)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDUS6_HUMAN, O75380: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    extracellular1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS15372108

    NDUFS6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDUFS6 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Metformin Pathway, Pharmacodynamic
    Metformin Pathway, Pharmacodynamic

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFS6
        Oxidative phosphorylation
    Electron Transport Chain


    1 Reactome Pathway for NDUFS6
        Respiratory electron transport

    1 PharmGKB Pathway for NDUFS6
        Metformin Pathway, Pharmacodynamic

    Selected Kegg Pathways  (Kegg details for NDUFS6) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFS6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFS6: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFS6 (O753802, 3 ENSP000002741374) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNH2Q128092, 3MINT-64086 I2D: score=5 
    MAP3K7O433182, 3MINT-8259910 I2D: score=2 
    MAPK6Q166592, 3MINT-8261538 I2D: score=2 
    MAPK8IP2Q133872, 3MINT-8262547 I2D: score=2 
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9647766
    GO:0006631fatty acid metabolic process IEA--
    GO:0006936muscle contraction IEA--
    GO:0010259multicellular organismal aging IEA--
    GO:0022904respiratory electron transport chain TAS--

    NDUFS6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFS6 (NDUS6)

    8 HMDB Compounds for NDUFS6    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFS6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NDUFS6 gene: 
    NM_004553.4  

    Unigene Cluster for NDUFS6:

    NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
    Hs.408257  [show with all ESTs]
    Unigene Representative Sequence: BM919105
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274137(uc003jcy.3) ENST00000469176 ENST00000510329

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    Additional mRNA sequence: 

    AF044959.1 AK022503.1 BC038664.1 BC046155.2 CR456880.1 

    8 DOTS entries:

    DT.414674  DT.100045618  DT.120840762  DT.100796916  DT.120840761  DT.120840771  DT.91838524  DT.421728 

    Selected AceView cDNA sequences (see all 234):

    BG473352 BE267268 BI085795 BM760487 F18459 BM708741 BQ924578 BI857723 
    BX110140 F27020 AJ708524 BF968557 F25835 AI492634 BM839798 BQ012958 
    CB110604 BC046155 BM764340 AA636013 AJ710114 AA662073 CB106827 AA534363 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDUFS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGTTACTGT
    NDUFS6 Expression
    About this image

    NDUFS6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFS6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.408257
        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFS6: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFS6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDUFS6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufs61 , 5 NADH dehydrogenase (ubiquinone) Fe-S protein 61, 5 82.76(n)1
    84.48(a)1
      13 (39.69 cM)5
    4077851  NM_010888.21  NP_035018.11 
     733198745 
    chicken
    (Gallus gallus)
    Aves NDUFS61 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa more 71(n)
    75.61(a)
      420976  XM_419061.4  XP_419061.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFS66
    NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13...
    71(a)
    1 ↔ 1
    4(68484462-68496676)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70702 Xenopus laevis transcribed sequence with moderate similarity more 79.29(n)    CB944646.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.151232 Transcribed sequence with moderate similarity to protein more 75.22(n)    BM004893.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86801 CG8680 59(n)
    63.22(a)
      33744  NM_135065.4  NP_608909.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nduf-61 nduf-6 53.1(n)
    54.65(a)
      184827  NM_059606.6  NP_492007.1 


    ENSEMBL Gene Tree for NDUFS6 (if available)
    TreeFam Gene Tree for NDUFS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDUFS6 gene

    NDUFS6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NDUFS6
    PGOHUM00000237780


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDUFS6 (see all 456)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486581341,2
    --1762939(+) GCACCA/GGAGCC 1 -- us2k10--------
    rs1998080491,2
    --1763056(+) CCGCA-/TCCCCC 1 -- us2k10--------
    rs22708261,2
    C,F--1763057(+) CCGCAT/CCCCCC 1 -- us2k15Minor allele frequency- C:0.10NA WA 10
    rs615253271,2
    C--1763063(+) CCCCCA/CACCCT 1 -- us2k10--------
    rs681239011,2
    C--1763063(-) AGGGT-/TGGGGG 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs68954391,2
    C,F--1763077(+) CTCTGA/CGACCG 1 -- us2k1 tfbs31Minor allele frequency- C:0.23WA 118
    rs1155635221,2
    F--1763119(+) GCCCAC/TTCGGG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1163518061,2
    C,F--1763121(+) CCACTC/GGGGGA 1 -- us2k11Minor allele frequency- G:0.10WA 118
    rs131871621,2
    C--1763184(+) TCTCAA/GGACAC 1 -- us2k18Minor allele frequency- G:0.49NA WA EA 368
    rs1440567651,2
    C--1763222(+) CCCTT-/ACCCGGCC
    GCACGCTCTC
    ACCCG
    1 -- cds10--------

    HapMap Linkage Disequilibrium report for NDUFS6 (1801496 - 1816719 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NDUFS6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272394CNV Insertion20981092
    esv268994CNV Insertion20981092

    Human Gene Mutation Database (HGMD): NDUFS6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFS6
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFS6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603848   
    OMIM disorders: 252010  
    13 diseases for NDUFS6:    About MalaCards
    mitochondrial complex i deficiency    lactic acidosis    huntington's disease    fatty liver disease
    parkinson's disease    atherosclerosis    schizophrenia    liver disease
    alzheimer's disease    malaria    prostate cancer    leukemia
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for NDUFS6:
    Leigh disease

    NDUFS6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NDUFS6
    Human Genome Epidemiology (HuGE) Navigator: NDUFS6 (5 documents)

    Export disorders for NDUFS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDUFS6 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with NDUFS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    8. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (Cytogenet. Cell Genet. 1998)
    9. cDNA sequence and chromosomal localization of the remaining three human nuclear encoded iron sulphur protein (IP) subunits of complex I: the human IP fraction is completed. (PubMed id 9647766)1, 2 Loeffen J.... Smeitink J. (Biochem. Biophys. Res. Commun. 1998)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4726 HGNC: 7713 AceView: NDUFS6 Ensembl:ENSG00000145494 euGenes: HUgn4726
    ECgene: NDUFS6 Kegg: 4726 H-InvDB: NDUFS6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NDUFS6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NDUFS6 gene:
    Search GeneIP for patents involving NDUFS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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