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Aliases for NDUFS6 Gene

Aliases for NDUFS6 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit S6 2 3 5
  • NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6, 13kDa (NADH-Coenzyme Q Reductase) 2 3
  • NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 6, Mitochondrial 2 3
  • NADH-Ubiquinone Oxidoreductase 13 KDa-A Subunit 3 4
  • Complex I 13kDa Subunit A 2 3
  • CI-13kD-A 3 4
  • NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6 (13kD) (NADH-Coenzyme Q Reductase) 2
  • Complex I, Mitochondrial Respiratory Chain, 13-KD Subunit 3
  • NADH:Ubiquinone Oxidoreductase NDUFS6 Subunit 3
  • Complex I-13kD-A 4
  • CI-13kA 3
  • CI13KDA 3

External Ids for NDUFS6 Gene

Previous GeneCards Identifiers for NDUFS6 Gene

  • GC05P001942
  • GC05P001834
  • GC05P001854

Summaries for NDUFS6 Gene

Entrez Gene Summary for NDUFS6 Gene

  • This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]

GeneCards Summary for NDUFS6 Gene

NDUFS6 (NADH:Ubiquinone Oxidoreductase Subunit S6) is a Protein Coding gene. Diseases associated with NDUFS6 include Mitochondrial Complex I Deficiency and Leigh Syndrome. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include electron carrier activity and NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFS6 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFS6 Gene

Additional gene information for NDUFS6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFS6 Gene

Genomics for NDUFS6 Gene

Regulatory Elements for NDUFS6 Gene

Enhancers for NDUFS6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H001948 1.2 ENCODE dbSUPER 10.5 +148.1 148091 2 ZNF493 ZNF133 ZNF2 GLIS2 ZNF416 FOS ZNF548 SP3 YY2 TSHZ1 SDHAP3 ENSG00000271119 LOC728613 LOC100132773 CTD-2194D22.4 LINC02116 MTCO2P32 LOC105374620 NDUFS6 MRPL36
GH05H001641 0.9 ENCODE 10.8 -159.6 -159632 0 ATF1 RB1 TBL1XR1 ARNT ARID4B ZNF2 ZSCAN9 RAD21 RFX5 ZNF143 SDHAP3 LOC728613 MRPL36 NDUFS6 ENSG00000250173 GC05M001591
GH05H001644 0.9 ENCODE 10.8 -156.3 -156312 0 ATF1 RB1 ARID4B SIN3A ZNF76 KLF17 BMI1 ZNF2 RAD21 RFX5 LOC728613 NDUFS6 MRPL36 ENSG00000250173 GC05M001591 PIR51678
GH05H001746 0.8 FANTOM5 10.9 -54.7 -54720 0 ATF1 L3MBTL2 TBL1XR1 ZBTB2 NCOA1 ZBTB40 GABPA TFDP1 MTA3 SMARCA4 MRPL36 NDUFS6 PIR36348 GC05M001700
GH05H001768 0.5 FANTOM5 11.9 -32.8 -32776 0 ZFHX2 NFIB EGR2 NDUFS6 MRPL36 PIR36348 LOC101929003
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NDUFS6 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000177603 -582 3201 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for NDUFS6 Gene

Chromosome:
5
Start:
1,801,382 bp from pter
End:
1,816,605 bp from pter
Size:
15,224 bases
Orientation:
Plus strand

Genomic View for NDUFS6 Gene

Genes around NDUFS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFS6 Gene

Proteins for NDUFS6 Gene

  • Protein details for NDUFS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75380-NDUS6_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
    Protein Accession:
    O75380

    Protein attributes for NDUFS6 Gene

    Size:
    124 amino acids
    Molecular mass:
    13712 Da
    Quaternary structure:
    • Mammalian complex I is composed of 45 different subunits (PubMed:12611891, PubMed:27626371). This is a component of the iron-sulfur (IP) fragment of the enzyme (PubMed:12611891).

neXtProt entry for NDUFS6 Gene

Post-translational modifications for NDUFS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFS6 Gene

Domains & Families for NDUFS6 Gene

Gene Families for NDUFS6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NDUFS6 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O75380

UniProtKB/Swiss-Prot:

NDUS6_HUMAN :
  • Belongs to the complex I NDUFS6 subunit family.
Family:
  • Belongs to the complex I NDUFS6 subunit family.
genes like me logo Genes that share domains with NDUFS6: view

Function for NDUFS6 Gene

Molecular function for NDUFS6 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),13kDa,component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),iron-sulfur protein 6,inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9647766
GO:0009055 electron carrier activity NAS 9647766
genes like me logo Genes that share ontologies with NDUFS6: view
genes like me logo Genes that share phenotypes with NDUFS6: view

Human Phenotype Ontology for NDUFS6 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for NDUFS6 Gene

miRTarBase miRNAs that target NDUFS6

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NDUFS6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFS6 Gene

Localization for NDUFS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFS6 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFS6 gene
Compartment Confidence
mitochondrion 5
plasma membrane 1
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for NDUFS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016020 membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with NDUFS6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NDUFS6 Gene

Pathways & Interactions for NDUFS6 Gene

genes like me logo Genes that share pathways with NDUFS6: view

Gene Ontology (GO) - Biological Process for NDUFS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone IBA,TAS --
GO:0006631 fatty acid metabolic process IEA --
GO:0006936 muscle contraction IEA --
GO:0010259 multicellular organism aging IEA --
GO:0022904 respiratory electron transport chain IEA --
genes like me logo Genes that share ontologies with NDUFS6: view

No data available for SIGNOR curated interactions for NDUFS6 Gene

Drugs & Compounds for NDUFS6 Gene

(5) Drugs for NDUFS6 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFS6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFS6: view

Transcripts for NDUFS6 Gene

mRNA/cDNA for NDUFS6 Gene

Unigene Clusters for NDUFS6 Gene

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NDUFS6
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFS6 Gene

No ASD Table

Relevant External Links for NDUFS6 Gene

GeneLoc Exon Structure for
NDUFS6
ECgene alternative splicing isoforms for
NDUFS6

Expression for NDUFS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDUFS6 Gene

mRNA differential expression in normal tissues according to GTEx for NDUFS6 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for NDUFS6 Gene

This gene is overexpressed in Heart (11.2), Peripheral blood mononuclear cells (7.4), and Brain (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFS6 Gene



Protein tissue co-expression partners for NDUFS6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFS6 Gene:

NDUFS6

SOURCE GeneReport for Unigene cluster for NDUFS6 Gene:

Hs.408257

Evidence on tissue expression from TISSUES for NDUFS6 Gene

  • Liver(4.4)
  • Lung(4.3)
  • Skin(4.3)
  • Heart(2.3)
  • Muscle(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFS6 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • cerebrospinal fluid
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • meninges
  • neck
  • skull
Thorax:
  • esophagus
  • heart
  • heart valve
  • lung
Abdomen:
  • adrenal gland
  • liver
  • stomach
Limb:
  • foot
  • lower limb
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • sweat gland
genes like me logo Genes that share expression patterns with NDUFS6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NDUFS6 Gene

Orthologs for NDUFS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFS6 33 34
  • 99.73 (n)
dog
(Canis familiaris)
Mammalia NDUFS6 34
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFS6 33 34
  • 83.06 (n)
mouse
(Mus musculus)
Mammalia Ndufs6 33 16 34
  • 82.76 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912599 33
  • 81.9 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 79 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFS6 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFS6 33 34
  • 71 (n)
lizard
(Anolis carolinensis)
Reptilia NDUFS6 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufs6 33
  • 70.59 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7070 33
zebrafish
(Danio rerio)
Actinopterygii ndufs6 33 34
  • 66.67 (n)
Dr.15123 33
fruit fly
(Drosophila melanogaster)
Insecta CG8680 33 34
  • 59 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009072 33
  • 55.26 (n)
worm
(Caenorhabditis elegans)
Secernentea nduf-6 33 34
  • 53.1 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5753 34
  • 38 (a)
OneToOne
Species where no ortholog for NDUFS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFS6 Gene

ENSEMBL:
Gene Tree for NDUFS6 (if available)
TreeFam:
Gene Tree for NDUFS6 (if available)

Paralogs for NDUFS6 Gene

Pseudogenes.org Pseudogenes for NDUFS6 Gene

genes like me logo Genes that share paralogs with NDUFS6: view

No data available for Paralogs for NDUFS6 Gene

Variants for NDUFS6 Gene

Sequence variations from dbSNP and Humsavar for NDUFS6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs267606913 Pathogenic, Mitochondrial complex I deficiency (MT-C1D) [MIM:252010] 1,815,885(+) TTACT(A/G)TGGGC reference, missense
rs863224110 Likely pathogenic 1,814,399(+) AGACT(C/T)GGGTG reference, missense
rs863224111 Likely pathogenic 1,814,457(+) TATAA(A/G/T)CTTGG reference, missense
rs10058270 Likely benign 1,815,836(+) TTCCT(C/T)TTGAA intron-variant
rs140887831 Uncertain significance 1,814,350(+) GAAAA(C/T)TTTGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NDUFS6 Gene

Variant ID Type Subtype PubMed ID
esv3603817 CNV gain 21293372
nsv1033147 CNV gain 25217958
nsv1140355 OTHER inversion 24896259

Variation tolerance for NDUFS6 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFS6 Gene

Human Gene Mutation Database (HGMD)
NDUFS6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFS6 Gene

Disorders for NDUFS6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NDUFS6 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial complex i deficiency
  • mitochondrial complex 1 deficiency
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
mitochondrial metabolism disease
  • mitochondrial diseases
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

NDUS6_HUMAN
  • Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. {ECO:0000269 PubMed:15372108, ECO:0000269 PubMed:19259137}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NDUFS6

Genetic Association Database (GAD)
NDUFS6
Human Genome Epidemiology (HuGE) Navigator
NDUFS6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFS6
genes like me logo Genes that share disorders with NDUFS6: view

No data available for Genatlas for NDUFS6 Gene

Publications for NDUFS6 Gene

  1. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 45 60
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 45 60
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 45 60

Products for NDUFS6 Gene

Sources for NDUFS6 Gene

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