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Aliases for NDUFS6 Gene

Aliases for NDUFS6 Gene

  • NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6, 13kDa (NADH-Coenzyme Q Reductase) 2 3
  • NADH-Ubiquinone Oxidoreductase 13 KDa-A Subunit 3 4
  • Complex I 13kDa Subunit A 2 3
  • CI-13kD-A 3 4
  • NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6 (13kD) (NADH-Coenzyme Q Reductase) 2
  • NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 6, Mitochondrial 3
  • Complex I, Mitochondrial Respiratory Chain, 13-KD Subunit 3
  • NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 6 2
  • NADH:Ubiquinone Oxidoreductase NDUFS6 Subunit 3
  • Complex I-13kD-A 4
  • Mitochondrial 2
  • CI-13kA 3
  • CI13KDA 3

External Ids for NDUFS6 Gene

Summaries for NDUFS6 Gene

Entrez Gene Summary for NDUFS6 Gene

  • This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]

GeneCards Summary for NDUFS6 Gene

NDUFS6 (NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6, 13kDa (NADH-Coenzyme Q Reductase)) is a Protein Coding gene. Diseases associated with NDUFS6 include mitochondrial complex i deficiency. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include electron carrier activity and NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFS6 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFS6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFS6 Gene

Genomics for NDUFS6 Gene

Genomic Location for NDUFS6 Gene

Start:
1,801,382 bp from pter
End:
1,816,605 bp from pter
Size:
15,224 bases
Orientation:
Plus strand

Genomic View for NDUFS6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFS6 Gene

Regulatory Elements for NDUFS6 Gene

Proteins for NDUFS6 Gene

  • Protein details for NDUFS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75380-NDUS6_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
    Protein Accession:
    O75380
    Secondary Accessions:

    Protein attributes for NDUFS6 Gene

    Size:
    124 amino acids
    Molecular mass:
    13712 Da
    Quaternary structure:
    • Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

neXtProt entry for NDUFS6 Gene

Proteomics data for NDUFS6 Gene at MOPED

Post-translational modifications for NDUFS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFS6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFS6 Gene

Domains for NDUFS6 Gene

Gene Families for NDUFS6 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFS6 Gene

Graphical View of Domain Structure for InterPro Entry

O75380

UniProtKB/Swiss-Prot:

NDUS6_HUMAN
Family:
  • Belongs to the complex I NDUFS6 subunit family.:
    • O75380
genes like me logo Genes that share domains with NDUFS6: view

Function for NDUFS6 Gene

Molecular function for NDUFS6 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),13kDa,component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),iron-sulfur protein 6,inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9647766
GO:0009055 electron carrier activity NAS 9647766
genes like me logo Genes that share ontologies with NDUFS6: view
genes like me logo Genes that share phenotypes with NDUFS6: view

miRNA for NDUFS6 Gene

miRTarBase miRNAs that target NDUFS6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFS6 Gene

Localization for NDUFS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFS6 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFS6 Gene COMPARTMENTS Subcellular localization image for NDUFS6 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NDUFS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 15372108
genes like me logo Genes that share ontologies with NDUFS6: view

Pathways for NDUFS6 Gene

genes like me logo Genes that share pathways with NDUFS6: view

Gene Ontology (GO) - Biological Process for NDUFS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9647766
GO:0006631 fatty acid metabolic process IEA --
GO:0006936 muscle contraction IEA --
GO:0010259 multicellular organismal aging IEA --
GO:0022904 respiratory electron transport chain TAS --
genes like me logo Genes that share ontologies with NDUFS6: view

Compounds for NDUFS6 Gene

(8) HMDB Compounds for NDUFS6 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFS6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFS6: view

Transcripts for NDUFS6 Gene

mRNA/cDNA for NDUFS6 Gene

Unigene Clusters for NDUFS6 Gene

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFS6 Gene

No ASD Table

Relevant External Links for NDUFS6 Gene

GeneLoc Exon Structure for
NDUFS6
ECgene alternative splicing isoforms for
NDUFS6

Expression for NDUFS6 Gene

mRNA expression in normal human tissues for NDUFS6 Gene

mRNA differential expression in normal tissues according to GTEx for NDUFS6 Gene

This gene is overexpressed in Heart - Left Ventricle (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFS6 Gene

SOURCE GeneReport for Unigene cluster for NDUFS6 Gene Hs.408257

genes like me logo Genes that share expressions with NDUFS6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NDUFS6 Gene

Orthologs for NDUFS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFS6 35
  • 99.73 (n)
  • 100 (a)
NDUFS6 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFS6 35
  • 83.06 (n)
  • 83.06 (a)
NDUFS6 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFS6 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufs6 35
  • 82.76 (n)
  • 84.48 (a)
Ndufs6 16
Ndufs6 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFS6 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC679739 35
  • 81.9 (n)
  • 84.48 (a)
chicken
(Gallus gallus)
Aves NDUFS6 35
  • 71 (n)
  • 75.61 (a)
NDUFS6 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFS6 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7070 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufs6 35
  • 70.59 (n)
  • 74.51 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.15123 35
ndufs6 35
  • 66.67 (n)
  • 74.23 (a)
ndufs6 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009072 35
  • 55.26 (n)
  • 46.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8680 35
  • 59 (n)
  • 63.22 (a)
CG8680 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea nduf-6 35
  • 53.1 (n)
  • 54.65 (a)
nduf-6 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5753 36
  • 38 (a)
OneToOne
Species with no ortholog for NDUFS6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFS6 Gene

ENSEMBL:
Gene Tree for NDUFS6 (if available)
TreeFam:
Gene Tree for NDUFS6 (if available)

Paralogs for NDUFS6 Gene

Pseudogenes.org Pseudogenes for NDUFS6 Gene

genes like me logo Genes that share paralogs with NDUFS6: view

No data available for Paralogs for NDUFS6 Gene

Variants for NDUFS6 Gene

Sequence variations from dbSNP and Humsavar for NDUFS6 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs375209 -- 1,807,197(+) TACTG(C/T)GTGAA intron-variant
rs457208 -- 1,807,153(+) TACTG(C/T)GTGAG intron-variant
rs904760 -- 1,811,365(+) AAAAA(A/C)CAAAA intron-variant
rs1018120 -- 1,806,513(+) GCACG(C/T)GGTGC intron-variant
rs1048092 -- 1,815,906(+) ACAGC(A/C)CCACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NDUFS6 Gene

Variant ID Type Subtype PubMed ID
esv268994 CNV Insertion 20981092
esv272394 CNV Insertion 20981092

Relevant External Links for NDUFS6 Gene

HapMap Linkage Disequilibrium report
NDUFS6
Human Gene Mutation Database (HGMD)
NDUFS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFS6 Gene

Disorders for NDUFS6 Gene

(1) OMIM Diseases for NDUFS6 Gene (603848)

(1) University of Copenhagen DISEASES for NDUFS6 Gene

Relevant External Links for NDUFS6

Genetic Association Database (GAD)
NDUFS6
Human Genome Epidemiology (HuGE) Navigator
NDUFS6
genes like me logo Genes that share disorders with NDUFS6: view

No data available for UniProtKB/Swiss-Prot for NDUFS6 Gene

Publications for NDUFS6 Gene

  1. cDNA sequence and chromosomal localization of the remaining three human nuclear encoded iron sulphur protein (IP) subunits of complex I: the human IP fraction is completed. (PMID: 9647766) Loeffen J. … Smeitink J. (Biochem. Biophys. Res. Commun. 1998) 3 4
  2. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 48

Products for NDUFS6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDUFS6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFS6
    • Block miRNA regulation of NDUFS6 using miScript Target Protectors
    • antibodies-online proteins for NDUFS6
    • antibodies-online antibodies for NDUFS6
    • antibodies-online kits for NDUFS6

    Sources for NDUFS6 Gene

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