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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDUFS6 Gene

protein-coding   GIFtS: 57
GCID: GC05P001801

NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme...

(Previous name: NADH dehydrogenase (ubiquinone) Fe-S protein 6 (13kD) (NADH-coenzyme...)
 Explore 10 diseases affiliated with
NDUFS6 via our new
 Human Malady Compendium 
Biological research products
for NDUFS6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6, 13kDa (NADH-Coenzyme Q
Reductase)1 2
     Complex I 13kDa Subunit A2
CI-13kA1 2     Complex I, Mitochondrial Respiratory Chain, 13-KD Subunit2
CI-13kD-A2 3     NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 6, Mitochondrial2
NADH-Ubiquinone Oxidoreductase 13 KDa-A Subunit2 3     NADH:Ubiquinone Oxidoreductase NDUFS6 Subunit2
NADH Dehydrogenase (Ubiquinone) Fe-S Protein 6 (13kD) (NADH-Coenzyme Q
Reductase)1
     Complex I-13kD-A3
CI13KDA2     

External Ids:    HGNC: 77131   Entrez Gene: 47262   Ensembl: ENSG000001454947   OMIM: 6038485   UniProtKB: O753803   

Export aliases for NDUFS6 gene to outside databases

Previous GC identifers: GC05P001942 GC05P001834 GC05P001854


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NDUFS6:
This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the
electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the
respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction.
Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical
disorders, including neonatal disease and adult-onset neurodegenerative disorders.(provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: NDUS6_HUMAN, O75380
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is
believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFS6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDUFS6 gene promoter:
         ER-alpha   RFX1   Pax-2   Nkx2-5   MIF-1   Pax-2a   GATA-1   MEF-2A   c-Myb   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFS6 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDUFS6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15.33

NDUFS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFS6 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P001801:  view genomic region     (about GC identifiers)

Start:
1,801,496 bp from pter      End:
1,816,719 bp from pter
Size:
15,224 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NDUS6_HUMAN, O75380 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial precursor  
Size: 124 amino acids; 13712 Da
Subunit: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment
of the enzyme
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side

Explore the universe of human proteins at neXtProt for NDUFS6: NX_O75380

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75380

  • NDUFS6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004544.1  
    ENSEMBL proteins: 
     ENSP00000274137   ENSP00000422557  
    Reactome Protein details: O75380
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    Uscn Proteins for NDUFS6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551


    NDUFS6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NDUFS6 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR019401 Znf_CHCC
     IPR016668 NADH_Ub_cplx-1_Fe-S_6_mit

    Graphical View of Domain Structure for InterPro Entry O75380

    ProtoNet protein and cluster: O75380

    UniProtKB/Swiss-Prot: NDUS6_HUMAN, O75380
    Similarity: Belongs to the complex I NDUFS6 subunit family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NDUS6_HUMAN, O75380
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is
    believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Genatlas biochemistry entry for NDUFS6:
    NADH ubiquinone oxidoreductase (Q reductase),13kDa,component of the complex I multi-subunit enzyme of the oxidative
    phosphorylation (OXPHOS),iron-sulfur protein 6,inner mitochondrial membrane

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
    GO:0009055electron carrier activity NAS9647766


    NDUFS6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NDUFS6:
     Decreased viability with pacli 

    Animal Models:
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ndufs6):
     cardiovascular system  cellular  growth/size  homeostasis/metabolism  mortality/aging 
     muscle  reproductive system 

    NDUFS6 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    8/9 pathways (see all 9)
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.1.00
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Oxidative phosphorylation0.52
    Electron Transport Chain0.76
    Alzheimer's disease0.43
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Huntington's disease0.40
    2Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    3Metformin Pathway, Pharmacodynamic
    Metformin Pathway, Pharmacodynamic1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for NDUFS6 
        Oxidative phosphorylation
    Electron Transport Chain

    4        Reactome Pathways for NDUFS6
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport

    1 PharmGKB Pathway for NDUFS6
        Metformin Pathway, Pharmacodynamic

    5         Kegg Pathways  (Kegg details for NDUFS6):
        Oxidative phosphorylation
    Metabolic pathways
    Alzheimer's disease
    Parkinson's disease
    Huntington's disease


    NDUFS6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/63 Interacting proteins for NDUFS6 (O753802, 3 ENSP000002741374) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNH2Q128092, 3MINT-64086 I2D: score=5 
    MAP3K7O433182, 3MINT-8259910 I2D: score=2 
    MAPK6Q166592, 3MINT-8261538 I2D: score=2 
    MAPK8IP2Q133872, 3MINT-8262547 I2D: score=2 
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0022904respiratory electron transport chain TAS--
    GO:0044281small molecule metabolic process TAS--


    NDUFS6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDUFS6

    8 HMDB Compounds for NDUFS6    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFS6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about NDUFS6 / NDUS6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDUFS6 gene: 
    NM_004553.4  

    Unigene Cluster for NDUFS6:

    NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
    Hs.408257  [show with all ESTs]
    Unigene Representative Sequence: BM919105
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274137(uc003jcy.3) ENST00000469176 ENST00000510329

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    Additional cDNA sequence: 

    AF044959.1 AK022503.1 BC038664.1 BC046155.2 CR456880.1 

    8 DOTS entries:

    DT.414674  DT.100045618  DT.120840762  DT.100796916  DT.120840761  DT.120840771  DT.91838524  DT.421728 

    24/234 AceView cDNA sequences (see all 234):

    BE263517 BQ962804 AI867493 AI492634 AJ709664 BI085795 AA554030 AA662073 
    BC038664 BI116694 BM840770 CB106827 F18459 BF968557 BM725271 BM834916 
    BI857723 AJ346026 AA345832 AJ710114 BM764340 BM808225 BU538101 BM760487 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDUFS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGTTACTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NDUFS6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDUFS6

    SOURCE GeneReport for Unigene cluster: Hs.408257
        SABiosciences Expression via Pathway-Focused PCR Array including NDUFS6: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NDUFS6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NDUFS6 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufs61 , 5 NADH dehydrogenase (ubiquinone) Fe-S protein 61, 5 82.76(n)1
    84.48(a)1
      13 (39.69 cM)5
    4077851  NM_010888.21  NP_035018.11 
     733198385 
    chicken
    (Gallus gallus)
    Aves NDUFS61 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa more 71(n)
    75.61(a)
      420976  XM_419061.3  XP_419061.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFS66
    --
    72(a)
    1 ↔ 1
    4(68484462-68493762)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70702 Xenopus laevis transcribed sequence with moderate similarity more 79.29(n)    CB944646.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.151232 Transcribed sequence with moderate similarity to protein more 75.22(n)    BM004893.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86801 CG8680 59(n)
    63.22(a)
      33744  NM_135065.3  NP_608909.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nduf-61 Protein NDUF-6 53.49(n)
    54.65(a)
      184827  NM_059606.5  NP_492007.1 


    ENSEMBL Gene Tree for NDUFS6 (if available)
    TreeFam Gene Tree for NDUFS6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDUFS6 gene

    NDUFS6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NDUFS6
    PGOHUM00000237780


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/364 NCBI SNPs in NDUFS6 are shown (see all 364    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486581341,2
    --1799619(+) GCACCA/GGAGCC 2 -- us2k1 int10--------
    rs1998080491,2
    --1799736(+) CCGCA-/TCCCCC 2 -- int1 us2k10--------
    rs22708261,2
    C,--1799737(+) CCGCAT/CCCCCC 2 -- int1 us2k15Minor allele frequency- C:0.10NA WA 10
    rs615253271,2
    C--1799743(+) CCCCCA/CACCCT 2 -- us2k1 int10--------
    rs681239011,2
    C,--1799743(-) AGGGT-/TGGGGG 2 -- us2k1 int11Minor allele frequency- T:0.00NA 2
    rs68954391,2
    C,F,--1799758(+) CTCTGA/CGACCG 2 -- int1 us2k1 tfbs31Minor allele frequency- C:0.23WA 118
    rs1155635221,2
    F,--1799800(+) GCCCAC/TTCGGG 2 -- int1 us2k11Minor allele frequency- T:0.02WA 118
    rs1163518061,2
    F,--1799802(+) CCACTC/GGGGGA 2 -- us2k1 int11Minor allele frequency- G:0.10WA 118
    rs131871621,2
    C,--1799865(+) TCTCAA/GGACAC 2 -- int1 us2k18Minor allele frequency- G:0.49NA WA EA 368
    rs1462895171,2
    C,--1799898(+) CGGCT-/CCCTTACC
    CGGCCACACG
    CCCTT
    2 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for NDUFS6 (1801496 - 1816719 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NDUFS6: --
    Human Gene Mutation Database (HGMD): NDUFS6

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NDUFS6 for disorders           About GeneDecksing

    OMIM gene information: 603848   
    OMIM disorders: 252010  
    10 diseases for NDUFS6:    About MalaCards
    mitochondrial complex i deficiency    lactic acidosis    leigh disease    huntington's disease
    parkinson's disease    atherosclerosis    cholesterol    schizophrenia
    leukemia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for NDUFS6:
    Leigh disease
    Human Genome Epidemiology (HuGE) Navigator: NDUFS6 (5 documents)

    Export disorders for NDUFS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDUFS6 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with NDUFS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
    3. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (1998)
    4. cDNA sequence and chromosomal localization of the remaining three human nuclear encoded iron sulphur protein (IP) subunits of complex I: the human IP fraction is completed. (PubMed id 9647766)1, 2 Loeffen J.... Smeitink J. (1998)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1 Saito A....Kamatani N. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4726 HGNC: 7713 AceView: NDUFS6 Ensembl:ENSG00000145494 euGenes: HUgn4726
    ECgene: NDUFS6 Kegg: 4726 H-InvDB: NDUFS6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDUFS6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDUFS6 gene:
    Search GeneIP for patents involving NDUFS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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