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Aliases for NDUFS5 Gene

Aliases for NDUFS5 Gene

  • NADH Dehydrogenase (Ubiquinone) Fe-S Protein 5, 15kDa (NADH-Coenzyme Q Reductase) 2 3
  • NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 5 2 3
  • Complex I-15 KDa 3 4
  • CI-15 KDa 3 4
  • NADH Dehydrogenase (Ubiquinone) Fe-S Protein 5 (15kD) (NADH-Coenzyme Q Reductase) 2
  • NADH:Ubiquinone Oxidoreductase 15 KDa IP Subunit 3
  • NADH-Ubiquinone Oxidoreductase 15 KDa Subunit 4
  • Complex I 51kDa Subunit 2
  • CI-15k 3
  • CI15K 3

External Ids for NDUFS5 Gene

Summaries for NDUFS5 Gene

Entrez Gene Summary for NDUFS5 Gene

  • This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]

GeneCards Summary for NDUFS5 Gene

NDUFS5 (NADH Dehydrogenase (Ubiquinone) Fe-S Protein 5, 15kDa (NADH-Coenzyme Q Reductase)) is a Protein Coding gene. Diseases associated with NDUFS5 include atrophic gastritis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFS5 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFS5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFS5 Gene

Genomics for NDUFS5 Gene

Genomic Location for NDUFS5 Gene

Start:
39,026,295 bp from pter
End:
39,034,636 bp from pter
Size:
8,342 bases
Orientation:
Plus strand

Genomic View for NDUFS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFS5 Gene

Regulatory Elements for NDUFS5 Gene

Proteins for NDUFS5 Gene

  • Protein details for NDUFS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43920-NDUS5_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
    Protein Accession:
    O43920
    Secondary Accessions:

    Protein attributes for NDUFS5 Gene

    Size:
    106 amino acids
    Molecular mass:
    12518 Da
    Quaternary structure:
    • Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.

neXtProt entry for NDUFS5 Gene

Proteomics data for NDUFS5 Gene at MOPED

Post-translational modifications for NDUFS5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8, Lys28, and Lys101

Other Protein References for NDUFS5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFS5 Gene

Domains for NDUFS5 Gene

Gene Families for NDUFS5 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFS5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NDUS5_HUMAN
Domain:
  • Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.:
    • O43920
Family:
  • Belongs to the complex I NDUFS5 subunit family.:
    • O43920
genes like me logo Genes that share domains with NDUFS5: view

Function for NDUFS5 Gene

Molecular function for NDUFS5 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),15kDa,component of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),iron-sulfur protein 5,inner mitochondrial membrane,expressed in heart,skeletal muscle,liver,kidney,fetal heart
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 10070614
genes like me logo Genes that share ontologies with NDUFS5: view

Phenotypes for NDUFS5 Gene

GenomeRNAi human phenotypes for NDUFS5:
genes like me logo Genes that share phenotypes with NDUFS5: view

miRNA for NDUFS5 Gene

miRTarBase miRNAs that target NDUFS5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFS5 Gene

Localization for NDUFS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFS5 Gene

Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFS5 Gene COMPARTMENTS Subcellular localization image for NDUFS5 gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NDUFS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 16826196
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 10070614
GO:0005758 mitochondrial intermembrane space IEA --
genes like me logo Genes that share ontologies with NDUFS5: view

Pathways for NDUFS5 Gene

genes like me logo Genes that share pathways with NDUFS5: view

Gene Ontology (GO) - Biological Process for NDUFS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 10070614
GO:0022904 respiratory electron transport chain TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly IMP 11112787
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFS5: view

Compounds for NDUFS5 Gene

(8) HMDB Compounds for NDUFS5 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFS5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFS5: view

Transcripts for NDUFS5 Gene

mRNA/cDNA for NDUFS5 Gene

Unigene Clusters for NDUFS5 Gene

NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFS5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for NDUFS5 Gene

GeneLoc Exon Structure for
NDUFS5
ECgene alternative splicing isoforms for
NDUFS5

Expression for NDUFS5 Gene

mRNA expression in normal human tissues for NDUFS5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFS5 Gene

SOURCE GeneReport for Unigene cluster for NDUFS5 Gene Hs.632385

genes like me logo Genes that share expressions with NDUFS5: view

Orthologs for NDUFS5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFS5 36
  • 100 (n)
  • 100 (a)
NDUFS5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFS5 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFS5 37
  • 49 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufs5 16
Ndufs5 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFS5 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFS5 37
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFS5 36
  • 59.12 (n)
  • 57.55 (a)
NDUFS5 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFS5 37
  • 57 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1159 36
zebrafish
(Danio rerio)
Actinopterygii Dr.13417 36
ndufs5 36
  • 65.71 (n)
  • 65.38 (a)
ndufs5 37
  • 64 (a)
OneToOne
Species with no ortholog for NDUFS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFS5 Gene

ENSEMBL:
Gene Tree for NDUFS5 (if available)
TreeFam:
Gene Tree for NDUFS5 (if available)

Paralogs for NDUFS5 Gene

genes like me logo Genes that share paralogs with NDUFS5: view

No data available for Paralogs for NDUFS5 Gene

Variants for NDUFS5 Gene

Sequence variations from dbSNP and Humsavar for NDUFS5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6981 -- 39,034,514(+) CTGAT(A/G)TCTGG utr-variant-3-prime
rs1050978 -- 39,034,460(+) CCTCC(A/C)CCTCA reference, synonymous-codon
rs1122472 -- 39,026,408(+) GTAGG(G/T)GCTGC intron-variant
rs1555741 -- 39,027,449(-) CCTAA(A/G)ATGAC intron-variant
rs1984600 -- 39,026,255(+) GTTTT(C/G)TGGGG upstream-variant-2KB

Relevant External Links for NDUFS5 Gene

HapMap Linkage Disequilibrium report
NDUFS5
Human Gene Mutation Database (HGMD)
NDUFS5

No data available for Structural Variations from Database of Genomic Variants (DGV) for NDUFS5 Gene

Disorders for NDUFS5 Gene

(1) MalaCards Diseases for NDUFS5 Gene

Search for NDUFS5 Gene in MalaCards »

Relevant External Links for NDUFS5

Genetic Association Database (GAD)
NDUFS5
Human Genome Epidemiology (HuGE) Navigator
NDUFS5
genes like me logo Genes that share disorders with NDUFS5: view

No data available for UniProtKB/Swiss-Prot for NDUFS5 Gene

Publications for NDUFS5 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. The human NADH:ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients. (PMID: 10070614) Loeffen J. … van den Heuvel L. (J. Inherit. Metab. Dis. 1999) 3 4 25
  3. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 49
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 49

Products for NDUFS5 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDUFS5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFS5
    • Block miRNA regulation of NDUFS5 using miScript Target Protectors
    • antibodies-online proteins for NDUFS5
    • antibodies-online antibodies for NDUFS5
    • antibodies-online kits for NDUFS5

    Sources for NDUFS5 Gene

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