NDUFS5 Gene
protein-coding GIFtS: 56
GCID: GC01P039491
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NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme...(Previous name: NADH dehydrogenase (ubiquinone) Fe-S protein 5 (15kD) (NADH-coenzyme...)
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Aliases
for NDUFS5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NADH Dehydrogenase (Ubiquinone) Fe-S Protein 5, 15kDa (NADH-Coenzyme QReductase)1 2 | | CI15K2 | | CI-15k1 2 | | NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 52 | | Complex I-15 KDa2 3 | | NADH:Ubiquinone Oxidoreductase 15 KDa IP Subunit2 | | CI-15 KDa2 3 | | NADH-Ubiquinone Oxidoreductase 15 KDa Subunit3 | | NADH Dehydrogenase (Ubiquinone) Fe-S Protein 5 (15kD) (NADH-Coenzyme QReductase)1 | | |
Export aliases for NDUFS5 gene to outside databasesPrevious GC identifers: GC01P039409 GC01P038493 GC01P038955 GC01P038905 GC01P039161 GC01P039264 GC01P037612 |
Summaries
for NDUFS5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NDUFS5:
This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is asubunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chainlocated in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants andpseudogenes have been identified on chromosomes 1, 4 and 17. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: NDUS5_HUMAN, O43920Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Wiki entry for NDUFS5
|
Genomic Views
for NDUFS5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDUFS5 gene promoter:
E47 C/EBPalpha Evi-1 CREB POU2F1 deltaCREB POU2F1a SEF-1 (1) ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFS5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFS5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.2-p33 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p34.2-p33NDUFS5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P039491: view genomic region
(about GC identifiers)
Start:
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39,491,967 bp from pter |
End:
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39,500,308 bp from pter |
Size:
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8,342 bases |
Orientation:
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plus strand |
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Proteins
for NDUFS5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NDUS5_HUMAN, O43920 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 Size: 106 amino acids; 12518 Da
Subunit: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragmentof the enzyme
Subcellular location: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein (Probable).Mitochondrion intermembrane space (Potential)Explore the universe of human proteins at neXtProt for NDUFS5: NX_O43920
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43920
NDUFS5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001171908.1 NP_004543.1
ENSEMBL proteins: ENSP00000362060 ENSP00000362058 Reactome Protein details: O43920
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NDUFS5 for ontologies About GeneDecksing
NDUFS5 Antibody Products:
Assay Products for NDUFS5: |
Protein
Domains /
Families
for NDUFS5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NDUFS5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O43920ProtoNet protein and cluster: O43920 UniProtKB/Swiss-Prot: NDUS5_HUMAN, O43920Domain: Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation ofintramolecular disulfide bondsSimilarity: Belongs to the complex I NDUFS5 subunit family |
Function
for NDUFS5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NDUS5_HUMAN, O43920Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone Genatlas biochemistry entry for NDUFS5:NADH ubiquinone oxidoreductase (Q reductase),15kDa,component of the complex I multi-subunit enzyme of the oxidativephosphorylation (OXPHOS),iron-sulfur protein 5,inner mitochondrial membrane,expressed in heart,skeletalmuscle,liver,kidney,fetal heart
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFS5 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFS5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
NAS | 9878551 |
NDUFS5 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for NDUFS5:
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Pathways & Interactions
for NDUFS5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NDUFS5
4 
Reactome Pathways for NDUFS5
5 
Kegg Pathways (Kegg details for NDUFS5):
NDUFS5 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFS5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/66 Interacting proteins for NDUFS5 (O439202, 3 ENSP000003620584) via UniProtKB, MINT, STRING, and/or I2D (see all 66)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
NAS | 9878551 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0032981 | mitochondrial respiratory chain complex I assembly |
IMP | 11112787 | | GO:0044281 | small molecule metabolic process |
TAS | -- |
NDUFS5 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDUFS5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NDUFS5
8 HMDB Compounds for NDUFS5 About this table
1 DrugBank Compound for NDUFS5 About this table
Search CenterWatch for drugs/clinical trials and news about NDUFS5 / NDUS5
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Transcripts
for NDUFS5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NDUFS5 gene (2 alternative transcripts): NM_001184979.1 NM_004552.2 Unigene Cluster for NDUFS5: NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) Hs.632385 [show with all ESTs]Unigene Representative Sequence: CD3852542 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372969(uc001ccx.3) ENST00000372967(uc001ccy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFS5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFS5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NDUFS5 (NM_004552) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDUFS5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFS5 |
Additional cDNA sequence: AF020352.1 AF047434.1 AF086268.1 AK312188.1 BC001884.1 BC093057.1 CR456904.1 13 DOTS entries: DT.418370 DT.99989960 DT.100798383 DT.120953626 DT.121423923 DT.100686452 DT.121423944 DT.100033320 DT.100798382 DT.100798384 DT.121423924 DT.121152528 DT.92452076 24/498 AceView cDNA sequences (see all 498): AA166708 BU156062 CD108167 W40363 BU192028 BE674695 AI289113 BE122917 BU732196 AI350523 AA040928 BE535414 AA844157 F35411 AI707540 CA312305 BQ212424 BM802968 F29202 BM912958 BM555130 BU676539 BE252464 BQ670000
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFS5 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b |
|---|
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| SP1: | | | | | | | | | |
| SP2: | | | | | | | | |
ECgene alternative splicing isoforms for NDUFS5
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Expression
for NDUFS5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDUFS5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAATCGGTTA
About this image
See NDUFS5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDUFS5
SOURCE GeneReport for Unigene cluster: Hs.632385
SABiosciences Expression via Pathway-Focused PCR Array including NDUFS5: | Mitochondrial Energy Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFS5
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFS5 |
Orthologs
for NDUFS5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NDUFS5 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for NDUFS5 (if available)
TreeFam Gene Tree for NDUFS5 (if available) |
Paralogs
for NDUFS5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NDUFS5 gene
NDUFS5 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for NDUFS5 (see all 7)
PGOHUM00000250814 PGOHUM00000244117 PGOHUM00000244724 PGOHUM00000245630 PGOHUM00000245671
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Genomic Variants
for NDUFS5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NDUFS5 (39491967 - 39500308 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NDUFS5: --
Human Gene Mutation Database (HGMD): NDUFS5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFS5 |
|
Disorders
/ Diseases
for NDUFS5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDUFS5 for disorders About GeneDecksing
OMIM gene information: 603847
OMIM disorders: --
6  diseases for NDUFS5: About MalaCardsatrophic gastritis gastritis multiple sclerosis huntington's disease
parkinson's disease prostatitis
Human Genome Epidemiology (HuGE) Navigator: NDUFS5 (5 documents)
Export disorders for NDUFS5 gene to outside databases
|
Publications
for NDUFS5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NDUFS5 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with NDUFS5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human NADH:ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients. (PubMed id 10070614)1, 2, 7 Loeffen J.... van den Heuvel L. (1999)
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (1998)
- NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I. (PubMed id 21310150)1, 2 Szklarczyk R....Huynen M.A. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
- Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (1998)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
|
External Searches for NDUFS5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDUFS5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFS5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFS5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NDUFS5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NDUFS5 gene:
Search GeneIP for patents involving NDUFS5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDUFS5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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