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NDUFS5 Gene

protein-coding   GIFtS: 62
GCID: GC01P039491

NADH Dehydrogenase (Ubiquinone) Fe-S Protein 5, 15kDa (NADH-Coenzyme...

(Previous name: NADH dehydrogenase (ubiquinone) Fe-S protein 5 (15kD) (NADH-coenzyme...)
  See NDUFS5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADH Dehydrogenase (Ubiquinone) Fe-S Protein 5, 15kDa (NADH-Coenzyme Q
Reductase)1 2
     NADH Dehydrogenase (Ubiquinone) Fe-S Protein 5 (15kD) (NADH-Coenzyme Q
Reductase)1
NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 51 2     CI-15k2
Complex I-15 KDa2 3     CI15K2
CI-15 KDa2 3     NADH:Ubiquinone Oxidoreductase 15 KDa IP Subunit2
Complex I 51kDa Subunit1     NADH-Ubiquinone Oxidoreductase 15 KDa Subunit3

External Ids:    HGNC: 77121   Entrez Gene: 47252   Ensembl: ENSG000001686537   OMIM: 6038475   UniProtKB: O439203   

Export aliases for NDUFS5 gene to outside databases

Previous GC identifers: GC01P039409 GC01P038493 GC01P038955 GC01P038905 GC01P039161 GC01P039264 GC01P037612


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDUFS5 Gene:
This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a
subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport
chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants
and pseudogenes have been identified on chromosomes 1, 4 and 17. (provided by RefSeq, May 2010)

GeneCards Summary for NDUFS5 Gene:
NDUFS5 (NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)) is a protein-coding gene. Diseases associated with NDUFS5 include atrophic gastritis. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NDUS5_HUMAN, O43920
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFS5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFS5 gene promoter:
         E47   C/EBPalpha   Evi-1   CREB   POU2F1   deltaCREB   POU2F1a   SEF-1 (1)   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFS5 promoter sequence
   Search Chromatin IP Primers for NDUFS5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFS5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2-p33   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.2-p33

NDUFS5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFS5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P039491:  view genomic region     (about GC identifiers)

Start:
39,491,967 bp from pter      End:
39,500,308 bp from pter
Size:
8,342 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NDUS5_HUMAN, O43920 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5  
Size: 106 amino acids; 12518 Da
Subunit: Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP)
fragment of the enzyme

Explore the universe of human proteins at neXtProt for NDUFS5: NX_O43920

Explore proteomics data for NDUFS5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys28, Lys101
  • Modification sites at PhosphoSitePlus

  • See NDUFS5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001171908.1  NP_004543.1  

    ENSEMBL proteins: 
     ENSP00000362060   ENSP00000362058  
    Reactome Protein details: O43920

    NDUFS5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    1 InterPro protein domain:
     IPR019342 NADH_UbQ_OxRdtase_FeS-su5

    Graphical View of Domain Structure for InterPro Entry O43920

    ProtoNet protein and cluster: O43920

    UniProtKB/Swiss-Prot: NDUS5_HUMAN, O43920
    Domain: Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the
    formation of intramolecular disulfide bonds
    Similarity: Belongs to the complex I NDUFS5 subunit family


    Find genes that share domains with NDUFS5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUS5_HUMAN, O43920
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Genatlas biochemistry entry for NDUFS5:
    NADH ubiquinone oxidoreductase (Q reductase),15kDa,component of the complex I multi-subunit enzyme of the
    oxidative phosphorylation (OXPHOS),iron-sulfur protein 5,inner mitochondrial membrane,expressed in heart,skeletal
    muscle,liver,kidney,fetal heart

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS10070614
         
    Find genes that share ontologies with NDUFS5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NDUFS5:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NDUFS5

    miRNA
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    miRTarBase miRNAs that target NDUFS5:
    hsa-let-7e-5p (MIRT051532), hsa-mir-1296-5p (MIRT036146)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDUS5_HUMAN, O43920: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein (Probable).
    Mitochondrion intermembrane space (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA16826196
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS10070614
    GO:0005758mitochondrial intermembrane space IEA--

    Find genes that share ontologies with NDUFS5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDUFS5 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44


    Find genes that share SuperPaths with NDUFS5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFS5
        Oxidative phosphorylation
    Electron Transport Chain

    1 Reactome Pathway for NDUFS5
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for NDUFS5) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease

        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFS5: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFS5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFS5 (O439202, 3 ENSP000003620584) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    NDUFA9Q167952, ENSP000002665444MINT-4981243 STRING: ENSP00000266544
    NDUFS3O754892, ENSP000002637744MINT-4981243 STRING: ENSP00000263774
    MT-ND1P038862, ENSP000003546874MINT-4981243 STRING: ENSP00000354687
    NDUFAF1Q9Y3752, ENSP000002603614MINT-4981243 STRING: ENSP00000260361
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS10070614
    GO:0022904respiratory electron transport chain TAS--
    GO:0032981mitochondrial respiratory chain complex I assembly IMP11112787
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with NDUFS5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFS5 (NDUS5)

    8 HMDB Compounds for NDUFS5    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFS5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 10070614 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDUFS5 gene (2 alternative transcripts): 
    NM_001184979.1  NM_004552.2  

    Unigene Cluster for NDUFS5:

    NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
    Hs.632385  [show with all ESTs]
    Unigene Representative Sequence: CD385254
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372969(uc001ccx.3) ENST00000372967(uc001ccy.3)
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    Additional mRNA sequence: 

    AF020352.1 AF047434.1 AF086268.1 AK312188.1 BC001884.1 BC093057.1 CR456904.1 

    13 DOTS entries:

    DT.418370  DT.99989960  DT.100798383  DT.120953626  DT.121423923  DT.100686452  DT.121423944  DT.100033320 
    DT.100798382  DT.100798384  DT.121423924  DT.121152528  DT.92452076 

    Selected AceView cDNA sequences (see all 498):

    AI342603 BQ642037 W40363 AA807946 BQ674333 F29202 BU156062 BU192028 
    AI339118 BU538285 BU732196 AA457506 AA166708 BE535414 AA307306 AA919114 
    CD675969 AA844157 CA312305 AF047434 F35576 AI123147 W67483 F35411 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFS5    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b
    SP1:                        
    SP2:                        


    ECgene alternative splicing isoforms for NDUFS5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDUFS5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCGGTTA
    NDUFS5 Expression
    About this image


    NDUFS5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    NDUFS5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFS5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632385
        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFS5: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFS5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NDUFS5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufs55 NADH dehydrogenase (ubiquinone) Fe-S protein 5   --   4 (57.42 cM) 123712710 
    chicken
    (Gallus gallus)
    Aves NDUFS51 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa more 59.12(n)
    57.55(a)
      771510  XM_001233574.2  XP_001233575.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFS56
    NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15...
    57(a)
    1 ↔ 1
    GL343481.1(607714-608533)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.134172 Transcribed sequence with weak similarity to protein more 73.95(n)    CK395617.1 


    ENSEMBL Gene Tree for NDUFS5 (if available)
    TreeFam Gene Tree for NDUFS5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDUFS5 gene

    Find genes that share paralogs with NDUFS5           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for NDUFS5 (see all 7)
    PGOHUM00000250814 PGOHUM00000244117 PGOHUM00000244724 PGOHUM00000245630 PGOHUM00000245671


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDUFS5 (see all 261)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115861851,2
    C,F--39493919(+) GCCAAC/AATGCT 2 -- int11Minor allele frequency- A:0.50WA 2
    rs354641641,2
    C--39494666(+) TTTTTT/-GAGAC 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs597099481,2
    --39496056(+) TGGGCA/GACAGA 2 -- int10--------
    rs350075551,2
    C--39496080(+) AAAAA-/AGATGG 2 -- int12Minor allele frequency- A:0.25NA CSA 4
    rs1138250711,2
    C,F--39496101(+) TGGCCC/TGGCAC 2 -- int12Minor allele frequency- T:0.09WA 120
    rs113477251,2
    C,F--39498274(+) ACAGCA/-AAAAA 2 -- int1 trp33Minor allele frequency- -:0.33NA CSA 6
    rs41477651,2
    C--39500437(+) CTCCTC/GCCTCA 2 -- ds50010--------
    rs21043851,2
    C,F,A--39570137(-) ttggcC/Taggat 2 -- us2k17Minor allele frequency- T:0.36NA WA CSA EA 249
    rs1892207561,2
    --39570200(+) GGTGGC/TGCACA 2 -- us2k10--------
    rs1919742651,2
    --39570246(+) AGAATC/TGCTTG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NDUFS5 (39491967 - 39500308 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NDUFS5: --
    Human Gene Mutation Database (HGMD): NDUFS5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFS5
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFS5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603847    OMIM disorders: --

    1 disease for NDUFS5:    
    About MalaCards
    atrophic gastritis


    Find genes that share disorders with NDUFS5           About GenesLikeMe

    Genetic Association Database (GAD): NDUFS5
    Human Genome Epidemiology (HuGE) Navigator: NDUFS5 (5 documents)

    Export disorders for NDUFS5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDUFS5 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with NDUFS5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human NADH:ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients. (PubMed id 10070614)1, 2, 7 Loeffen J.... van den Heuvel L. (J. Inherit. Metab. Dis. 1999)
    2. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    3. NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I. (PubMed id 21310150)1, 2 Szklarczyk R....Huynen M.A. (FEBS Lett. 2011)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    9. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (Cytogenet. Cell Genet. 1998)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4725 HGNC: 7712 AceView: NDUFS5 Ensembl:ENSG00000168653 euGenes: HUgn4725
    ECgene: NDUFS5 Kegg: 4725 H-InvDB: NDUFS5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NDUFS5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NDUFS5 gene:
    Search GeneIP for patents involving NDUFS5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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