Aliases for NDUFS3 Gene
- NADH:Ubiquinone Oxidoreductase Core Subunit S3 2 3 5
- NADH Dehydrogenase (Ubiquinone) Fe-S Protein 3, 30kDa (NADH-Coenzyme Q Reductase) 2 3
- NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 3, Mitochondrial 2 3
- NADH-Ubiquinone Oxidoreductase 30 KDa Subunit 3 4
- Complex I 30kDa Subunit 2 3
- Complex I-30kD 3 4
- CI-30kD 3 4
External Ids for NDUFS3 Gene
Previous GeneCards Identifiers for NDUFS3 Gene
This gene encodes one of the iron-sulfur protein (IP) components of mitochondrial NADH:ubiquinone oxidoreductase (complex I). Mutations in this gene are associated with Leigh syndrome resulting from mitochondrial complex I deficiency.[provided by RefSeq, Apr 2009]
GeneCards Summary for NDUFS3 Gene
NDUFS3 (NADH:Ubiquinone Oxidoreductase Core Subunit S3) is a Protein Coding gene. Diseases associated with NDUFS3 include Leigh Syndrome and Mitochondrial Complex I Deficiency. Among its related pathways are Metabolism and cardiolipin biosynthesis. GO annotations related to this gene include electron carrier activity and oxidoreductase activity, acting on NAD(P)H.
UniProtKB/Swiss-Prot for NDUFS3 Gene
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).