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Aliases for NDUFC2-KCTD14 Gene

Aliases for NDUFC2-KCTD14 Gene

  • NDUFC2-KCTD14 Readthrough 2 3 5
  • NDUFC2-KCTD14 Readthrough Transcript Protein 4

External Ids for NDUFC2-KCTD14 Gene

Previous GeneCards Identifiers for NDUFC2-KCTD14 Gene

  • GC11U901800
  • GC11M077728

Summaries for NDUFC2-KCTD14 Gene

Entrez Gene Summary for NDUFC2-KCTD14 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NDUFC2 (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa) and KCTD14 (potassium channel tetramerisation domain containing 14) genes on chromosome 11. The read-through transcripts share sequence identity with the upstream gene product and one variant has a frameshifted C-terminal region derived from the downstream gene exons. [provided by RefSeq, Feb 2011]

GeneCards Summary for NDUFC2-KCTD14 Gene

NDUFC2-KCTD14 (NDUFC2-KCTD14 Readthrough) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is NDUFC2.

UniProtKB/Swiss-Prot for NDUFC2-KCTD14 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFC2-KCTD14 Gene

Genomics for NDUFC2-KCTD14 Gene

Regulatory Elements for NDUFC2-KCTD14 Gene

Enhancers for NDUFC2-KCTD14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F078077 1.2 ENCODE 0.8 +0.3 255 4.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC KCTD21-AS1 RPL21P95 LOC101928865 NARS2 NDUFC2 NDUFC2-KCTD14 THRSP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NDUFC2-KCTD14 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFC2-KCTD14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320584 719 2201 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for NDUFC2-KCTD14 Gene

Chromosome:
11
Start:
78,015,715 bp from pter
End:
78,080,219 bp from pter
Size:
64,505 bases
Orientation:
Minus strand

Genomic View for NDUFC2-KCTD14 Gene

Genes around NDUFC2-KCTD14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFC2-KCTD14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFC2-KCTD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFC2-KCTD14 Gene

Proteins for NDUFC2-KCTD14 Gene

  • Protein details for NDUFC2-KCTD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PQ53-NDUCR_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2
    Protein Accession:
    E9PQ53

    Protein attributes for NDUFC2-KCTD14 Gene

    Size:
    114 amino acids
    Molecular mass:
    13408 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFC2-KCTD14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFC2-KCTD14 Gene

Post-translational modifications for NDUFC2-KCTD14 Gene

No Post-translational modifications

Other Protein References for NDUFC2-KCTD14 Gene

No data available for DME Specific Peptides for NDUFC2-KCTD14 Gene

Domains & Families for NDUFC2-KCTD14 Gene

Protein Domains for NDUFC2-KCTD14 Gene

Graphical View of Domain Structure for InterPro Entry

E9PQ53

UniProtKB/Swiss-Prot:

NDUCR_HUMAN :
  • Belongs to the complex I NDUFC2 subunit family.
Family:
  • Belongs to the complex I NDUFC2 subunit family.
genes like me logo Genes that share domains with NDUFC2-KCTD14: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for NDUFC2-KCTD14 Gene

Function for NDUFC2-KCTD14 Gene

Molecular function for NDUFC2-KCTD14 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Gene Ontology (GO) - Molecular Function for NDUFC2-KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity IEA --
genes like me logo Genes that share ontologies with NDUFC2-KCTD14: view

Phenotypes for NDUFC2-KCTD14 Gene

genes like me logo Genes that share phenotypes with NDUFC2-KCTD14: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFC2-KCTD14 Gene

Localization for NDUFC2-KCTD14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFC2-KCTD14 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFC2-KCTD14 gene
Compartment Confidence
mitochondrion 4

Gene Ontology (GO) - Cellular Components for NDUFC2-KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with NDUFC2-KCTD14: view

Pathways & Interactions for NDUFC2-KCTD14 Gene

genes like me logo Genes that share pathways with NDUFC2-KCTD14: view

Pathways by source for NDUFC2-KCTD14 Gene

Interacting Proteins for NDUFC2-KCTD14 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000432614%0d%0a9606.ENSP00000007516%0d%0a
Selected Interacting proteins: ENSP00000432614 for NDUFC2-KCTD14 Gene via STRING

Symbol External ID(s) Details
NDUFAB1

Gene Ontology (GO) - Biological Process for NDUFC2-KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFC2-KCTD14: view

No data available for SIGNOR curated interactions for NDUFC2-KCTD14 Gene

Transcripts for NDUFC2-KCTD14 Gene

mRNA/cDNA for NDUFC2-KCTD14 Gene

(3) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFC2-KCTD14 Gene

No ASD Table

Relevant External Links for NDUFC2-KCTD14 Gene

GeneLoc Exon Structure for
NDUFC2-KCTD14
ECgene alternative splicing isoforms for
NDUFC2-KCTD14

Expression for NDUFC2-KCTD14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NDUFC2-KCTD14 Gene

genes like me logo Genes that share expression patterns with NDUFC2-KCTD14: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NDUFC2-KCTD14 Gene

Orthologs for NDUFC2-KCTD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFC2-KCTD14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFC2 35
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ndufc2 35
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves NDUFC2 34 35
  • 57.35 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 41 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii NDUFC2 35
  • 36 (a)
OneToMany
Species where no ortholog for NDUFC2-KCTD14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFC2-KCTD14 Gene

ENSEMBL:
Gene Tree for NDUFC2-KCTD14 (if available)
TreeFam:
Gene Tree for NDUFC2-KCTD14 (if available)

Paralogs for NDUFC2-KCTD14 Gene

Paralogs for NDUFC2-KCTD14 Gene

(1) SIMAP similar genes for NDUFC2-KCTD14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NDUFC2-KCTD14: view

Variants for NDUFC2-KCTD14 Gene

Sequence variations from dbSNP and Humsavar for NDUFC2-KCTD14 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1045245 -- 78,015,815(-) TTCTT(C/T)TGAGA utr-variant-3-prime
rs10536825 -- 78,068,777(+) AGACT(-/GTC)GTCTC intron-variant, downstream-variant-500B, cds-indel
rs10578176 -- 78,052,937(+) TCTTC(-/T)TTTTT intron-variant
rs10590527 -- 78,061,021(+) GTCTC(-/A)AAAAA intron-variant
rs10593747 -- 78,061,029(+) AAAAA(-/AA)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFC2-KCTD14 Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV gain 19592680
nsv516638 CNV loss 19592680
nsv1140483 CNV tandem duplication 24896259
nsv1050891 CNV gain 25217958
esv3626891 CNV loss 21293372
esv2660024 CNV deletion 23128226

Variation tolerance for NDUFC2-KCTD14 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFC2-KCTD14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFC2-KCTD14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFC2-KCTD14 Gene

Disorders for NDUFC2-KCTD14 Gene

Relevant External Links for NDUFC2-KCTD14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFC2-KCTD14

No disorders were found for NDUFC2-KCTD14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFC2-KCTD14 Gene

Publications for NDUFC2-KCTD14 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64

Products for NDUFC2-KCTD14 Gene

Sources for NDUFC2-KCTD14 Gene

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