NDUFC2-KCTD14 Gene
protein-coding GIFtS: 23
GCID: GC11M077728
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NDUFC2-KCTD14 readthrough
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Aliases
for NDUFC2-KCTD14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NDUFC2-KCTD14 Readthrough1 2 | | NDUFC2-KCTD14 Protein2 |
Export aliases for NDUFC2-KCTD14 gene to outside databasesPrevious GC identifer: GC11U901800 |
Summaries
for NDUFC2-KCTD14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NDUFC2-KCTD14:
This locus represents naturally occurring read-through transcription between the neighboring NDUFC2 (NADH dehydrogenase(ubiquinone) 1, subcomplex unknown, 2, 14.5kDa) and KCTD14 (potassium channel tetramerisation domain containing 14)genes on chromosome 11. The read-through transcripts share sequence identity with the upstream gene product and onevariant has a frameshifted C-terminal region derived from the downstream gene exons. (provided by RefSeq, Feb 2011)
UniProtKB/TrEMBL: E9PQ53 Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
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Genomic Views
for NDUFC2-KCTD14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NDUFC2-KCTD14
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFC2-KCTD14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFC2-KCTD14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q14.1NDUFC2-KCTD14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M077728: view genomic region
(about GC identifiers)
Start:
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77,728,017 bp from pter |
End:
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77,790,911 bp from pter |
Size:
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62,895 bases |
Orientation:
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minus strand |
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Proteins
for NDUFC2-KCTD14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/TrEMBL: E9PQ53 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] 1 subunit C2 Size: 114 amino acids; 13408 Da
Subcellular location: Mitochondrion inner membrane (By similarity)
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataUniProtKB/TrEMBL: E9PRQ4 (See
protein sequence) Recommended Name: Protein NDUFC2-KCTD14 Size: 66 amino acids; 7486 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered aspreliminary dataNDUFC2-KCTD14 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (3 alternative transcripts):
NP_001190189.1 NP_001190190.1 NP_001190191.1
ENSEMBL proteins: ENSP00000435967 ENSP00000432614
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NDUFC2-KCTD14 for ontologies About GeneDecksing
NDUFC2-KCTD14 Antibody Products:
Assay Products for NDUFC2-KCTD14: |
Protein
Domains /
Families
for NDUFC2-KCTD14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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NDUFC2-KCTD14 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry E9PQ53Graphical View of Domain Structure for InterPro Entry E9PRQ4ProtoNet protein and cluster: E9PQ53 UniProtKB/TrEMBL: E9PQ53 Similarity: Belongs to the complex I NDUFC2 subunit family |
Function
for NDUFC2-KCTD14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Function Summary:
UniProtKB/TrEMBL: E9PQ53 Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC2-KCTD14 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
-- | -- |
NDUFC2-KCTD14 for ontologies About GeneDecksing
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Pathways & Interactions
for NDUFC2-KCTD14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | |
2  BioSystems Pathways for NDUFC2-KCTD14
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFC2-KCTD14
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
-- | -- |
NDUFC2-KCTD14 for ontologies About GeneDecksing
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Drugs & Compounds
for NDUFC2-KCTD14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NDUFC2-KCTD14
Search CenterWatch for drugs/clinical trials and news about NDUFC2-KCTD14
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Transcripts
for NDUFC2-KCTD14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for NDUFC2-KCTD14 gene (3 alternative transcripts): NM_001203260.1 NM_001203261.1 NM_001203262.1 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000528251 ENST00000530054
GeneLoc Exon Structure
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Expression
for NDUFC2-KCTD14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDUFC2-KCTD14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for NDUFC2-KCTD14
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat NDUFC2-KCTD14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFC2-KCTD14 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFC2-KCTD14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC2-KCTD14 |
Orthologs
for NDUFC2-KCTD14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of chordates.
Orthologs for NDUFC2-KCTD14 gene from 3/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
-- |
-- |
43(a) |
1 → many |
Un(11820072-11820739) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
43(a) |
1 → many |
GL343337.1(537961-544068) |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1101556 |
zgc:110155 |
34(a) |
1 → many |
15(9568400-9568685) |
ENSEMBL Gene Tree for NDUFC2-KCTD14 (if available)
TreeFam Gene Tree for NDUFC2-KCTD14 (if available) |
Paralogs
for NDUFC2-KCTD14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NDUFC2-KCTD14 gene
- NDUFC22
1 SIMAP similar gene for NDUFC2-KCTD14 using alignment to 2 protein entries: E9PQ53_HUMAN (see all proteins):NDUFC2
NDUFC2-KCTD14 for paralogs About GeneDecksing
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Genomic Variants
for NDUFC2-KCTD14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NDUFC2-KCTD14 (77728017 - 77790911 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NDUFC2-KCTD14: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for NDUFC2-KCTD14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for NDUFC2-KCTD14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed article for NDUFC2-KCTD14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NDUFC2-KCTD14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
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External Searches for NDUFC2-KCTD14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NDUFC2-KCTD14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFC2-KCTD14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFC2-KCTD14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for NDUFC2-KCTD14 gene:
Search GeneIP for patents involving NDUFC2-KCTD14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for NDUFC2-KCTD14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFC2-KCTD14 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFC2-KCTD14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFC2-KCTD14 | | | Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFC2-KCTD14 | | | Search QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFC2-KCTD14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFC2-KCTD14 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC2-KCTD14 |
|  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NDUFC2-KCTD14 |
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