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Aliases for NDUFC2-KCTD14 Gene

Aliases for NDUFC2-KCTD14 Gene

  • NDUFC2-KCTD14 Readthrough 2 3
  • NDUFC2-KCTD14 Readthrough Transcript Protein 4

External Ids for NDUFC2-KCTD14 Gene

Summaries for NDUFC2-KCTD14 Gene

Entrez Gene Summary for NDUFC2-KCTD14 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NDUFC2 (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa) and KCTD14 (potassium channel tetramerisation domain containing 14) genes on chromosome 11. The read-through transcripts share sequence identity with the upstream gene product and one variant has a frameshifted C-terminal region derived from the downstream gene exons. [provided by RefSeq, Feb 2011]

GeneCards Summary for NDUFC2-KCTD14 Gene

NDUFC2-KCTD14 (NDUFC2-KCTD14 Readthrough) is a Protein Coding gene. Among its related pathways are Metabolism and Alzheimers disease. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is NDUFC2.

UniProtKB/Swiss-Prot for NDUFC2-KCTD14 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFC2-KCTD14 Gene

Genomics for NDUFC2-KCTD14 Gene

Genomic Location for NDUFC2-KCTD14 Gene

Start:
78,015,715 bp from pter
End:
78,080,219 bp from pter
Size:
64,505 bases
Orientation:
Minus strand

Genomic View for NDUFC2-KCTD14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFC2-KCTD14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFC2-KCTD14 Gene

No data available for Regulatory Elements for NDUFC2-KCTD14 Gene

Proteins for NDUFC2-KCTD14 Gene

  • Protein details for NDUFC2-KCTD14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E9PQ53-NDUCR_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2
    Protein Accession:
    E9PQ53
    Secondary Accessions:

    Protein attributes for NDUFC2-KCTD14 Gene

    Size:
    114 amino acids
    Molecular mass:
    13408 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits

    Alternative splice isoforms for NDUFC2-KCTD14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFC2-KCTD14 Gene

Proteomics data for NDUFC2-KCTD14 Gene at MOPED

Post-translational modifications for NDUFC2-KCTD14 Gene

No Post-translational modifications

Other Protein References for NDUFC2-KCTD14 Gene

No data available for DME Specific Peptides for NDUFC2-KCTD14 Gene

Domains for NDUFC2-KCTD14 Gene

Protein Domains for NDUFC2-KCTD14 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NDUCR_HUMAN
Family:
  • Belongs to the complex I NDUFC2 subunit family.:
    • E9PQ53
genes like me logo Genes that share domains with NDUFC2-KCTD14: view

No data available for Gene Families for NDUFC2-KCTD14 Gene

Function for NDUFC2-KCTD14 Gene

Molecular function for NDUFC2-KCTD14 Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Gene Ontology (GO) - Molecular Function for NDUFC2-KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity IEA --
genes like me logo Genes that share ontologies with NDUFC2-KCTD14: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NDUFC2-KCTD14 Gene

Localization for NDUFC2-KCTD14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFC2-KCTD14 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Gene Ontology (GO) - Cellular Components for NDUFC2-KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with NDUFC2-KCTD14: view

Pathways for NDUFC2-KCTD14 Gene

genes like me logo Genes that share pathways with NDUFC2-KCTD14: view

Pathways by source for NDUFC2-KCTD14 Gene

Interacting Proteins for NDUFC2-KCTD14 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000432614%0d%0a9606.ENSP00000007516%0d%0a
Selected Interacting proteins: ENSP00000432614 for NDUFC2-KCTD14 Gene via STRING

Symbol External ID(s) Details
NDUFAB1

Gene Ontology (GO) - Biological Process for NDUFC2-KCTD14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone IEA --
genes like me logo Genes that share ontologies with NDUFC2-KCTD14: view

Transcripts for NDUFC2-KCTD14 Gene

mRNA/cDNA for NDUFC2-KCTD14 Gene

(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFC2-KCTD14 Gene

No ASD Table

Relevant External Links for NDUFC2-KCTD14 Gene

GeneLoc Exon Structure for
NDUFC2-KCTD14
ECgene alternative splicing isoforms for
NDUFC2-KCTD14

Expression for NDUFC2-KCTD14 Gene

mRNA expression in normal human tissues for NDUFC2-KCTD14 Gene

genes like me logo Genes that share expressions with NDUFC2-KCTD14: view

Orthologs for NDUFC2-KCTD14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFC2-KCTD14 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFC2 37
  • 64 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ndufc2 37
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves NDUFC2 36
  • 57.35 (n)
  • 51.61 (a)
NDUFC2 37
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 41 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii NDUFC2 37
  • 36 (a)
OneToMany
Species with no ortholog for NDUFC2-KCTD14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFC2-KCTD14 Gene

ENSEMBL:
Gene Tree for NDUFC2-KCTD14 (if available)
TreeFam:
Gene Tree for NDUFC2-KCTD14 (if available)

Paralogs for NDUFC2-KCTD14 Gene

Paralogs for NDUFC2-KCTD14 Gene

Selected SIMAP similar genes for NDUFC2-KCTD14 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NDUFC2-KCTD14: view

Variants for NDUFC2-KCTD14 Gene

Sequence variations from dbSNP and Humsavar for NDUFC2-KCTD14 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs470585 -- 78,061,408(+) TGTCC(A/G)AGCTA intron-variant
rs506250 -- 78,058,705(+) ccacc(A/G)tgcct intron-variant
rs507029 -- 78,058,756(+) AAATT(A/G)CTCTT intron-variant
rs527216 -- 78,061,340(+) TTGAC(A/G)AGAGG intron-variant
rs582732 -- 78,057,646(-) CATGC(A/G)TGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFC2-KCTD14 Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV Gain 19592680
nsv516638 CNV Loss 19592680
esv2660024 CNV Deletion 23128226

Relevant External Links for NDUFC2-KCTD14 Gene

HapMap Linkage Disequilibrium report
NDUFC2-KCTD14

Disorders for NDUFC2-KCTD14 Gene

No disorders were found for NDUFC2-KCTD14 Gene.

No data available for UniProtKB/Swiss-Prot for NDUFC2-KCTD14 Gene

Publications for NDUFC2-KCTD14 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  3. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for NDUFC2-KCTD14 Gene

Sources for NDUFC2-KCTD14 Gene

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