NDUFC2 Gene
protein-coding GIFtS: 55
GCID: GC11M077779
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NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2,...(Previous names: NADH dehydrogenase (ubiquinone) 1, subcomplex unknown,...)
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Aliases
for NDUFC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 2, 14.5kDa1 2 | | NADH-Ubiquinone Oxidoreductase Subunit B14.5b2 3 | | HLC-11 2 3 | | NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 2 (14.5kD, B14.5b)1 | | B14.5b1 2 | | NADHDH22 | | Complex I-B14.5b2 3 | | Complex I Subunit B14.5b2 | | Human Lung Cancer Oncogene 1 Protein2 3 | | NADH Dehydrogenase [Ubiquinone] 1 Subunit C22 | | CI-B14.5b2 3 | | |
Export aliases for NDUFC2 gene to outside databasesPrevious GC identifers: GC11M080106 GC11M079318 GC11M077950 GC11M077505 GC11M077457 GC11M074077 |
Summaries
for NDUFC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NDUC2_HUMAN, O95298Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Wiki entry for NDUFC2
|
Genomic Views
for NDUFC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDUFC2 gene promoter:
NF-1 Pax-5 HOXA3 Max PPAR-gamma1 HFH-1 PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q14.1NDUFC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M077779: view genomic region
(about GC identifiers)
Start:
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77,779,350 bp from pter |
End:
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77,791,265 bp from pter |
Size:
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11,916 bases |
Orientation:
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minus strand |
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Proteins
for NDUFC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NDUC2_HUMAN, O95298 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] 1 subunit C2 Size: 119 amino acids; 14188 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
Secondary accessions: Q549M5 Q6FIH8 Q9UBJ9Explore the universe of human proteins at neXtProt for NDUFC2: NX_O95298
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95298
NDUFC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001190983.1 NP_001190984.1 NP_004540.1
ENSEMBL proteins: ENSP00000281031 ENSP00000432739 ENSP00000432253 ENSP00000434262 ENSP00000435017 Reactome Protein details: O95298
Human Recombinant Protein Products for NDUFC2:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
NDUFC2 for ontologies About GeneDecksing
NDUFC2 Antibody Products:
Assay Products for NDUFC2: |
Protein
Domains /
Families
for NDUFC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NDUFC2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95298ProtoNet protein and cluster: O95298 1 Blocks protein family: IPB009423 NADH-ubiquinone oxidoreductase subunit b14.5b
UniProtKB/Swiss-Prot: NDUC2_HUMAN, O95298Similarity: Belongs to the complex I NDUFC2 subunit family |
Function
for NDUFC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: NDUC2_HUMAN, O95298Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
NAS | 9878551 |
NDUFC2 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NDUFC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC2 |
|
Pathways & Interactions
for NDUFC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NDUFC2
4 
Reactome Pathways for NDUFC2
5 
Kegg Pathways (Kegg details for NDUFC2):
NDUFC2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/57 Interacting proteins for NDUFC2 (O952983 ENSP000002810314) via UniProtKB, MINT, STRING, and/or I2D (see all 57)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
NAS | 9878551 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
NDUFC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDUFC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NDUFC2
8 HMDB Compounds for NDUFC2 About this table
2 DrugBank Compounds for NDUFC2 About this table
Search CenterWatch for drugs/clinical trials and news about NDUFC2 / NDUC2
|
Transcripts
for NDUFC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NDUFC2 gene (3 alternative transcripts): NM_001204054.1 NM_001204055.1 NM_004549.5 Unigene Cluster for NDUFC2: NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa Hs.407860 [show with all ESTs]Unigene Representative Sequence: NM_0045495 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000281031(uc009yuw.3 uc021qnv.1 uc021qnw.1) ENST00000527806
ENST00000534029 ENST00000525085 ENST00000528164
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NDUFC2 (NM_001204054) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDUFC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFC2 |
Additional cDNA sequence: AF070652.1 AF087659.1 AF087899.1 AF369952.1 AK022785.1 AK023013.1 AK098173.1 AL050278.1 BC007323.2 CR533448.1 15 DOTS entries: DT.95171696 DT.100844445 DT.95171701 DT.98132119 DT.100779703 DT.120729615 DT.100844446 DT.316024 DT.95296993 DT.100844453 DT.120729598 DT.95171710 DT.100693869 DT.100703008 DT.428135 24/399 AceView cDNA sequences (see all 399): BE220615 AA159925 AA406612 AW805771 CA844343 CB993622 AI086323 AA975096 BQ311752 AA165036 CA431120 AA075378 CD514699 AA531027 BX281908 AI564934 BU631809 AA111971 AA855001 AU106893 AI073862 BU630021 AA232684 AA290991
GeneLoc Exon Structure
|
Expression
for NDUFC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDUFC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NDUFC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDUFC2
SOURCE GeneReport for Unigene cluster: Hs.407860
SABiosciences Expression via Pathway-Focused PCR Array including NDUFC2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC2 |
Orthologs
for NDUFC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NDUFC2 gene from 4/8 species (see all 8) About this table
ENSEMBL Gene Tree for NDUFC2 (if available)
TreeFam Gene Tree for NDUFC2 (if available) |
Paralogs
for NDUFC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NDUFC2 gene
- NDUFC2-KCTD142
1 SIMAP similar gene for NDUFC2 using alignment to 5 protein entries: NDUC2_HUMAN (see all proteins):NDUFC2-KCTD14
NDUFC2 for paralogs About GeneDecksing
|
Genomic Variants
for NDUFC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NDUFC2 (77779350 - 77791265 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NDUFC2: --
Human Gene Mutation Database (HGMD): NDUFC2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFC2 |
|
Disorders
/ Diseases
for NDUFC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDUFC2 for disorders About GeneDecksing
OMIM gene information: 603845
OMIM disorders: --
9  diseases for NDUFC2: About MalaCardslung cancer papillary thyroid carcinoma folliculitis thyroid carcinoma
huntington's disease parkinson's disease thyroiditis carcinoma
prostatitis
Human Genome Epidemiology (HuGE) Navigator: NDUFC2 (8 documents)
Export disorders for NDUFC2 gene to outside databases
|
Publications
for NDUFC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NDUFC2 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with NDUFC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2, 3 Loeffen J.L....Smeitink J.A. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. (PubMed id 23028138)1 Nitert M.D....Ling C. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for NDUFC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDUFC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NDUFC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NDUFC2 gene:
Search GeneIP for patents involving NDUFC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDUFC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFC2 |
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 | | | NDUFC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC2 |
|  |  |  |  | | | | ThermoFisher Antibodies for NDUFC2 |
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