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NDUFC2 Gene

protein-coding   GIFtS: 60
GCID: GC11M077779

NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 2,...

(Previous names: NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 2, 14.5kDa1 2     NADH-Ubiquinone Oxidoreductase Subunit B14.5b2 3
Complex I Subunit B14.5b1 2     Human Lung Cancer Oncogene 11
Complex I-B14.5b2 3     NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 2 (14.5kD, B14.5b)1
Human Lung Cancer Oncogene 1 Protein2 3     B14.5b2
CI-B14.5b2 3     NADHDH22
HLC-12 3     NADH Dehydrogenase [Ubiquinone] 1 Subunit C22

External Ids:    HGNC: 77061   Entrez Gene: 47182   Ensembl: ENSG000001513667   OMIM: 6038455   UniProtKB: O952983   

Export aliases for NDUFC2 gene to outside databases

Previous GC identifers: GC11M080106 GC11M079318 GC11M077950 GC11M077505 GC11M077457 GC11M074077


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NDUFC2 Gene:
NDUFC2 (NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa) is a protein-coding gene. Diseases associated with NDUFC2 include folliculitis, and lung cancer. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is NDUFC2-KCTD14.

UniProtKB/Swiss-Prot: NDUC2_HUMAN, O95298
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFC2 gene promoter:
         NF-1   Pax-5   HOXA3   Max   PPAR-gamma1   HFH-1   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFC2 promoter sequence
   Search Chromatin IP Primers for NDUFC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1   Ensembl cytogenetic band:  11q14.1   HGNC cytogenetic band: 11q14.1

NDUFC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFC2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M077779:  view genomic region     (about GC identifiers)

Start:
77,779,350 bp from pter      End:
77,791,265 bp from pter
Size:
11,916 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDUC2_HUMAN, O95298 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 subunit C2  
Size: 119 amino acids; 14188 Da
Subunit: Complex I is composed of 45 different subunits
Secondary accessions: E9PNU8 E9PRB2 Q549M5 Q6FIH8 Q9UBJ9
Alternative splicing: 4 isoforms:  O95298-1   O95298-2   O95298-3   E9PQ53-1   (Based on a readthrough transcript which may produce a NDUFC2-KCTD14 fusion protein. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDUFC2: NX_O95298

Explore proteomics data for NDUFC2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106, Lys114
  • Modification sites at PhosphoSitePlus

  • See NDUFC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001190983.1  NP_001190984.1  NP_004540.1  

    ENSEMBL proteins: 
     ENSP00000281031   ENSP00000432739   ENSP00000432253   ENSP00000434262   ENSP00000435017  
    Reactome Protein details: O95298

    NDUFC2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    1 InterPro protein domain:
     IPR009423 NADH-UbQ_OxRdtase_b14.5b_su

    Graphical View of Domain Structure for InterPro Entry O95298

    ProtoNet protein and cluster: O95298

    1 Blocks protein domain: IPB009423 NADH-ubiquinone oxidoreductase subunit b14.5b

    UniProtKB/Swiss-Prot: NDUC2_HUMAN, O95298
    Similarity: Belongs to the complex I NDUFC2 subunit family


    NDUFC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUC2_HUMAN, O95298
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    NDUFC2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFC2
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    miRNA
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    miRTarBase miRNAs that target NDUFC2:
    hsa-mir-769-3p (MIRT039104), hsa-mir-128-3p (MIRT045857), hsa-mir-100-5p (MIRT048415)

    Block miRNA regulation of human, mouse, rat NDUFC2 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NDUFC2:
    hsa-miR-34c-5p hsa-miR-34a hsa-miR-449b hsa-miR-3920 hsa-miR-494 hsa-miR-449a hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmidNDUFC2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NDUFC2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDUC2_HUMAN, O95298: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0016021integral component of membrane IEA--
    GO:0070469respiratory chain ----

    NDUFC2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDUFC2 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFC2
        Oxidative phosphorylation
    Electron Transport Chain

    1 Reactome Pathway for NDUFC2
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for NDUFC2) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFC2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFC2: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFC2 (O952983 ENSP000002810314) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
    CYC1ENSP000003171594STRING: ENSP00000317159
    MT-ND1ENSP000003546874STRING: ENSP00000354687
    MT-ND4ENSP000003549614STRING: ENSP00000354961
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFC2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFC2 (NDUC2)

    8 HMDB Compounds for NDUFC2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    2 DrugBank Compounds for NDUFC2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17015645 17513495 17614984 17496098 16898010
    Carvedilol-- 72956-09-3targetinhibitor10666308



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NDUFC2 gene (3 alternative transcripts): 
    NM_001204054.1  NM_001204055.1  NM_004549.5  

    Unigene Cluster for NDUFC2:

    NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
    Hs.407860  [show with all ESTs]
    Unigene Representative Sequence: NM_004549
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281031(uc009yuw.3 uc021qnv.1 uc021qnw.1) ENST00000527806
    ENST00000534029 ENST00000525085 ENST00000528164
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate NDUFC2:
    hsa-miR-34c-5p hsa-miR-34a hsa-miR-449b hsa-miR-3920 hsa-miR-494 hsa-miR-449a hsa-miR-1262
    SwitchGear 3'UTR luciferase reporter plasmidNDUFC2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat NDUFC2
      QuantiFast Probe-based Assays in human, mouse, rat NDUFC2

    Additional mRNA sequence: 

    AF070652.1 AF087659.1 AF087899.1 AF369952.1 AK022785.1 AK023013.1 AK098173.1 AL050278.1 
    BC007323.2 CR533448.1 

    15 DOTS entries:

    DT.95171696  DT.100844445  DT.95171701  DT.98132119  DT.100779703  DT.120729615  DT.100844446  DT.316024 
    DT.95296993  DT.100844453  DT.120729598  DT.95171710  DT.100693869  DT.100703008  DT.428135 

    Selected AceView cDNA sequences (see all 399):

    BE220615 AA111971 AA159925 AA406612 AA855001 AA194882 CR613975 BM700256 
    AA586904 BU173363 AI653801 AI400365 AA902708 CB961387 BX281908 AA531027 
    AI564934 BU631809 AA232684 AI073862 AA290990 AI934779 AW805771 CA844343 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDUFC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NDUFC2 Expression
    About this image


    NDUFC2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    NDUFC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.407860
        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFC2: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NDUFC2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufc21 , 5 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, more1, 5 79.55(n)1
    68.91(a)1
      7 (53.49 cM)5
    681971  NM_024220.21  NP_077182.11 
     974000035 
    chicken
    (Gallus gallus)
    Aves NDUFC26
    Gallus gallus NADH dehydrogenase (ubiquinone) 1, s...
    49(a)
    1 → many
    1(192061273-192064192) ENSGALG00000029172
    lizard
    (Anolis carolinensis)
    Reptilia --
    NADH dehydrogenase [ubiquinone] 1 subunit C2
    48(a)
    1 → many
    GL343337.1(537961-544068)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004889201 NADH dehydrogenase [ubiquinone] 1 subunit C2-like 53.7(n)
    45.37(a)
      100488920  XM_002943353.2  XP_002943399.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1101551 zgc:110155 53.58(n)
    43.93(a)
      541390  NM_001013517.1  NP_001013535.1 


    ENSEMBL Gene Tree for NDUFC2 (if available)
    TreeFam Gene Tree for NDUFC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDUFC2 gene
    NDUFC2-KCTD142  
    1 SIMAP similar gene for NDUFC2 using alignment to 3 protein entries:     NDUC2_HUMAN (see all proteins):
    NDUFC2-KCTD14

    NDUFC2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for NDUFC2    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs88751,2,4
    ----see VAR_0144862 mis40--------

    HapMap Linkage Disequilibrium report for NDUFC2 (77779350 - 77791265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NDUFC2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520740CNV Gain19592680

    Human Gene Mutation Database (HGMD): NDUFC2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFC2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603845    OMIM disorders: --

    11 diseases for NDUFC2:    
    About MalaCards
    folliculitis    lung cancer    papillary thyroid carcinoma    huntington's disease
    fatty liver disease    parkinson's disease    thyroiditis    liver disease
    alzheimer's disease    prostate cancer    prostatitis


    NDUFC2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NDUFC2
    Human Genome Epidemiology (HuGE) Navigator: NDUFC2 (8 documents)

    Export disorders for NDUFC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDUFC2 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with NDUFC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2, 3 Loeffen J.L.C.M.... Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    6. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    7. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4718 HGNC: 7706 AceView: NDUFC2andKCTD14 Ensembl:ENSG00000151366 euGenes: HUgn4718
    ECgene: NDUFC2 Kegg: 4718 H-InvDB: NDUFC2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDUFC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDUFC2 gene:
    Search GeneIP for patents involving NDUFC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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