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Aliases for NDUFC2 Gene

Aliases for NDUFC2 Gene

  • NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 2, 14.5kDa 2 3
  • NADH-Ubiquinone Oxidoreductase Subunit B14.5b 3 4
  • Human Lung Cancer Oncogene 1 Protein 3 4
  • Complex I Subunit B14.5b 2 3
  • Complex I-B14.5b 3 4
  • CI-B14.5b 3 4
  • HLC-1 3 4
  • NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 2 (14.5kD, B14.5b) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Subunit C2 3
  • Human Lung Cancer Oncogene 1 2
  • NADHDH2 3
  • B14.5b 3

External Ids for NDUFC2 Gene

Summaries for NDUFC2 Gene

GeneCards Summary for NDUFC2 Gene

NDUFC2 (NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 2, 14.5kDa) is a Protein Coding gene. Diseases associated with NDUFC2 include lung cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is NDUFC2-KCTD14.

UniProtKB/Swiss-Prot for NDUFC2 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFC2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFC2 Gene

Genomics for NDUFC2 Gene

Genomic Location for NDUFC2 Gene

Start:
78,068,304 bp from pter
End:
78,080,219 bp from pter
Size:
11,916 bases
Orientation:
Minus strand

Genomic View for NDUFC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFC2 Gene

Regulatory Elements for NDUFC2 Gene

Proteins for NDUFC2 Gene

  • Protein details for NDUFC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95298-NDUC2_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 subunit C2
    Protein Accession:
    O95298
    Secondary Accessions:
    • E9PNU8
    • E9PRB2
    • Q549M5
    • Q6FIH8
    • Q9UBJ9

    Protein attributes for NDUFC2 Gene

    Size:
    119 amino acids
    Molecular mass:
    14188 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFC2 Gene

Proteomics data for NDUFC2 Gene at MOPED

Post-translational modifications for NDUFC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys106 and Lys114

Other Protein References for NDUFC2 Gene

No data available for DME Specific Peptides for NDUFC2 Gene

Domains for NDUFC2 Gene

Gene Families for NDUFC2 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFC2 Gene

UniProtKB/Swiss-Prot:

NDUC2_HUMAN
Family:
  • Belongs to the complex I NDUFC2 subunit family.:
    • O95298
genes like me logo Genes that share domains with NDUFC2: view

Function for NDUFC2 Gene

Molecular function for NDUFC2 Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFC2: view

miRNA for NDUFC2 Gene

miRTarBase miRNAs that target NDUFC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFC2 Gene

Localization for NDUFC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFC2 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFC2 Gene COMPARTMENTS Subcellular localization image for NDUFC2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for NDUFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016021 integral component of membrane IEA --
GO:0070469 respiratory chain --
genes like me logo Genes that share ontologies with NDUFC2: view

Pathways for NDUFC2 Gene

genes like me logo Genes that share pathways with NDUFC2: view

Gene Ontology (GO) - Biological Process for NDUFC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFC2: view

Compounds for NDUFC2 Gene

(8) HMDB Compounds for NDUFC2 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(2) Drugbank Compounds for NDUFC2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Carvedilol
72956-09-3 target inhibitor
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFC2: view

Transcripts for NDUFC2 Gene

Unigene Clusters for NDUFC2 Gene

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFC2 Gene

No ASD Table

Relevant External Links for NDUFC2 Gene

GeneLoc Exon Structure for
NDUFC2
ECgene alternative splicing isoforms for
NDUFC2

Expression for NDUFC2 Gene

mRNA expression in normal human tissues for NDUFC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFC2 Gene

SOURCE GeneReport for Unigene cluster for NDUFC2 Gene Hs.407860

genes like me logo Genes that share expressions with NDUFC2: view

Orthologs for NDUFC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFC2 36
  • 99.44 (n)
  • 99.16 (a)
NDUFC2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFC2 36
  • 83.47 (n)
  • 73.95 (a)
NDUFC2 37
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 69 (a)
OneToMany
NDUFC2 36
  • 82.63 (n)
  • 69.75 (a)
mouse
(Mus musculus)
Mammalia Ndufc2 36
  • 79.55 (n)
  • 68.91 (a)
Ndufc2 16
Ndufc2 37
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ndufc2 36
  • 81.51 (n)
  • 73.11 (a)
chicken
(Gallus gallus)
Aves NDUFC2 37
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 48 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488920 36
  • 53.7 (n)
  • 45.37 (a)
zebrafish
(Danio rerio)
Actinopterygii NDUFC2 37
  • 48 (a)
OneToMany
zgc:110155 36
  • 53.58 (n)
  • 43.93 (a)
Species with no ortholog for NDUFC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFC2 Gene

ENSEMBL:
Gene Tree for NDUFC2 (if available)
TreeFam:
Gene Tree for NDUFC2 (if available)

Paralogs for NDUFC2 Gene

Paralogs for NDUFC2 Gene

Selected SIMAP similar genes for NDUFC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NDUFC2: view

Variants for NDUFC2 Gene

Sequence variations from dbSNP and Humsavar for NDUFC2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_014486 -

Structural Variations from Database of Genomic Variants (DGV) for NDUFC2 Gene

Variant ID Type Subtype PubMed ID
nsv520740 CNV Gain 19592680

Relevant External Links for NDUFC2 Gene

HapMap Linkage Disequilibrium report
NDUFC2
Human Gene Mutation Database (HGMD)
NDUFC2

Disorders for NDUFC2 Gene

(1) MalaCards Diseases for NDUFC2 Gene

Search for NDUFC2 Gene in MalaCards »

Relevant External Links for NDUFC2

Genetic Association Database (GAD)
NDUFC2
Human Genome Epidemiology (HuGE) Navigator
NDUFC2
genes like me logo Genes that share disorders with NDUFC2: view

No data available for UniProtKB/Swiss-Prot for NDUFC2 Gene

Publications for NDUFC2 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 49

Products for NDUFC2 Gene

Sources for NDUFC2 Gene

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