NDUFC1 Gene
protein-coding GIFtS: 49
GCID: GC04M140212
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NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1,...(Previous names: NADH dehydrogenase (ubiquinone) 1, subcomplex unknown,...)
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Aliases
for NDUFC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 1, 6kDa1 2 | | NADH-Ubiquinone Oxidoreductase KFYI Subunit2 3 | | KFYI1 2 | | NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 1 (6kD, KFYI)1 | | Complex I-KFYI2 3 | | Complex I KFYI Subunit2 | | CI-KFYI2 3 | | NADH Dehydrogenase [Ubiquinone] 1 Subunit C1, Mitochondrial2 |
Export aliases for NDUFC1 gene to outside databasesPrevious GC identifers: GC04M141092 GC04M140510 GC04M140677 GC04M140788 GC04M140568 GC04M140430 GC04M135941 |
Summaries
for NDUFC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NDUFC1:
The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in theelectron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multipletranscript variants. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: NDUC1_HUMAN, O43677Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Wiki entry for NDUFC1
|
Genomic Views
for NDUFC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDUFC1 gene promoter:
Max1 HFH-3 Pax-5 AREB6 FOXI1 SRY POU2F1 POU2F1a POU2F1b POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q31.1 Ensembl cytogenetic band: 4q31.1 HGNC cytogenetic band: 4q31.1NDUFC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M140212: view genomic region
(about GC identifiers)
Start:
|
140,188,034 bp from pter |
End:
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140,223,705 bp from pter |
Size:
|
35,672 bases |
Orientation:
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minus strand |
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Proteins
for NDUFC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NDUC1_HUMAN, O43677 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor Size: 76 amino acids; 8734 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
Secondary accessions: A8K532 Q3MIJ9Explore the universe of human proteins at neXtProt for NDUFC1: NX_O43677
NDUFC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (7 alternative transcripts):
NP_001171915.1 NP_001171916.1 NP_001171917.1 NP_001171918.1 NP_001171919.1 NP_001171920.1 NP_002485.1
ENSEMBL proteins: ENSP00000425882 ENSP00000377775 ENSP00000421195 ENSP00000377770 ENSP00000439882 ENSP00000441126 ENSP00000440133 ENSP00000265500 Reactome Protein details: O43677
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NDUFC1 for ontologies About GeneDecksing
NDUFC1 Antibody Products:
Assay Products for NDUFC1: |
Protein
Domains /
Families
for NDUFC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NDUFC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O43677ProtoNet protein and cluster: O43677 UniProtKB/Swiss-Prot: NDUC1_HUMAN, O43677Similarity: Belongs to the complex I NDUFC1 subunit family |
Function
for NDUFC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NDUC1_HUMAN, O43677Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone Genatlas biochemistry entry for NDUFC1:NADH ubiquinone oxidoreductase (Q reductase),6kDa,subcomplex unkknown,1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFC1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFC1 (see all 7)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
NAS | 9878551 |
NDUFC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NDUFC1:
|
Pathways & Interactions
for NDUFC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NDUFC1
4 
Reactome Pathways for NDUFC1
5 
Kegg Pathways (Kegg details for NDUFC1):
NDUFC1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFC1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for NDUFC1 (ENSP000002655004) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
NAS | 9878551 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
NDUFC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDUFC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NDUFC1
8 HMDB Compounds for NDUFC1 About this table
1 DrugBank Compound for NDUFC1 About this table
Search CenterWatch for drugs/clinical trials and news about NDUFC1 / NDUC1
|
Transcripts
for NDUFC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NDUFC1 gene (7 alternative transcripts): NM_001184986.1 NM_001184987.1 NM_001184988.1 NM_001184989.1 NM_001184990.1 NM_001184991.1 NM_002494.3 Unigene Cluster for NDUFC1: NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa Hs.84549 [show with all ESTs]Unigene Representative Sequence: BM46753112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000503997 ENST00000394228(uc021xsc.1) ENST00000505036 ENST00000394225
ENST00000503453 ENST00000394223 ENST00000513022 ENST00000507764 ENST00000539387(uc021xsa.1 uc021xsb.1 uc021xsd.1)
ENST00000544855(uc003ihs.3) ENST00000539002(uc021xrz.1 uc003iht.3)
ENST00000265500
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFC1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFC1 (see all 7)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 7): NDUFC1 (NM_002494) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF047184.1 AF047435.1 AK291147.1 BC101798.1 BC107682.1 BC112061.1 CR457005.1 15 DOTS entries: DT.100035253 DT.317733 DT.100032176 DT.92430613 DT.97847843 DT.121255747 DT.100054509 DT.100820001 DT.121255694 DT.95169359 DT.100047364 DT.121255644 DT.317732 DT.95193775 DT.120755649 24/304 AceView cDNA sequences (see all 304): AI373800 BM831140 BM715083 BU740296 AI017138 AI801864 AI554792 CB160001 W56292 BU677336 AI810871 AI862578 AI478529 BF194849 BF434221 BU732860 AI671335 AI571334 AA058591 BQ636845 F21132 BQ638374 AW001005 AA627422
GeneLoc Exon Structure
|
Expression
for NDUFC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDUFC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NDUFC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDUFC1
SOURCE GeneReport for Unigene cluster: Hs.84549
SABiosciences Expression via Pathway-Focused PCR Array including NDUFC1: | Mitochondrial Energy Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFC1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC1 |
Orthologs
for NDUFC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for NDUFC1 gene from 1/5 species (see all 5) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ndufc11 , 5 |
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, more1, 5 |
79.39(n)1
75(a)1 |
|
3 (22.47 cM)5
663771 NM_025523.11 NP_079799.11
514046775 |
ENSEMBL Gene Tree for NDUFC1 (if available)
TreeFam Gene Tree for NDUFC1 (if available) |
Paralogs
for NDUFC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NDUFC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFC1 |
|
Disorders
/ Diseases
for NDUFC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDUFC1 for disorders About GeneDecksing
OMIM gene information: 603844
OMIM disorders: --
4  diseases for NDUFC1: About MalaCardsintrahepatic cholangiocarcinoma huntington's disease cholangiocarcinoma parkinson's disease
Export disorders for NDUFC1 gene to outside databases
|
Publications
for NDUFC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NDUFC1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with NDUFC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PubMed id 9425316)1, 2, 3 Ton C....Liew C.C. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (1998)
- Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (1998)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
- How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
|
External Searches for NDUFC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDUFC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NDUFC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NDUFC1 gene:
Search GeneIP for patents involving NDUFC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDUFC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFC1 |
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| |  |  |  |  | | | | |
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 | | | NDUFC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFC1 |
|  |  |  | | | | Search ThermoFisher Antibodies for NDUFC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFC1 |
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