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Aliases for NDUFC1 Gene

Aliases for NDUFC1 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit C1 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 1, 6kDa 2 3
  • NADH-Ubiquinone Oxidoreductase KFYI Subunit 3 4
  • Complex I KFYI Subunit 2 3
  • Complex I-KFYI 3 4
  • CI-KFYI 3 4
  • NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 1 (6kD, KFYI) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Subunit C1, Mitochondrial 3
  • KFYI 3

External Ids for NDUFC1 Gene

Previous GeneCards Identifiers for NDUFC1 Gene

  • GC04M141092
  • GC04M140510
  • GC04M140677
  • GC04M140788
  • GC04M140568
  • GC04M140430
  • GC04M140212
  • GC04M135941

Summaries for NDUFC1 Gene

Entrez Gene Summary for NDUFC1 Gene

  • The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for NDUFC1 Gene

NDUFC1 (NADH:Ubiquinone Oxidoreductase Subunit C1) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFC1 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFC1 Gene

Genomics for NDUFC1 Gene

Regulatory Elements for NDUFC1 Gene

Enhancers for NDUFC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F139299 0.7 ENCODE 20.8 +1.0 988 4.3 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NDUFC1 RAB33B MAML3 RNU6-1074P MGARP NAA15
GH04F139294 0.6 ENCODE 20.2 +6.8 6797 2.1 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 NDUFC1 RAB33B RNU6-1074P ELF2 RNU6-1214P GC04P139295 NAA15
GH04F139296 0.5 ENCODE 20.1 +5.4 5388 0.4 HDAC1 PKNOX1 CBX3 ZNF316 SCRT2 EED FOS CREM MAFK JUNB NDUFC1 RNU6-1074P GC04P139295 NAA15
GH04F139319 0.8 Ensembl 20 -17.2 -17150 0.2 NDUFC1 RNU6-1214P GC04P139370
GH04F139311 1.3 FANTOM5 Ensembl ENCODE 19.1 -12.0 -11950 6.2 PKNOX1 RAD21 YY1 ZNF335 GLIS2 FOS CREM EGR2 ZNF202 ZNF263 NDUFC1 MGARP MAML3 RAB33B H3F3AP6 ELF2 GC04P139319
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NDUFC1 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001250287 1151 4001 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for NDUFC1 Gene

Chromosome:
4
Start:
139,266,880 bp from pter
End:
139,302,551 bp from pter
Size:
35,672 bases
Orientation:
Minus strand

Genomic View for NDUFC1 Gene

Genes around NDUFC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFC1 Gene

Proteins for NDUFC1 Gene

  • Protein details for NDUFC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43677-NDUC1_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
    Protein Accession:
    O43677
    Secondary Accessions:
    • A8K532
    • Q3MIJ9

    Protein attributes for NDUFC1 Gene

    Size:
    76 amino acids
    Molecular mass:
    8734 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

neXtProt entry for NDUFC1 Gene

Post-translational modifications for NDUFC1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NDUFC1 Gene

Domains & Families for NDUFC1 Gene

Protein Domains for NDUFC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFC1 Gene

Graphical View of Domain Structure for InterPro Entry

O43677

UniProtKB/Swiss-Prot:

NDUC1_HUMAN :
  • Belongs to the complex I NDUFC1 subunit family.
Family:
  • Belongs to the complex I NDUFC1 subunit family.
genes like me logo Genes that share domains with NDUFC1: view

Function for NDUFC1 Gene

Molecular function for NDUFC1 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),6kDa,subcomplex unkknown,1
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS,TAS 9878551
genes like me logo Genes that share ontologies with NDUFC1: view
genes like me logo Genes that share phenotypes with NDUFC1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NDUFC1 Gene

Localization for NDUFC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFC1 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFC1 Gene COMPARTMENTS Subcellular localization image for NDUFC1 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for NDUFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0005747 mitochondrial respiratory chain complex I IEA,NAS 9878551
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDUFC1: view

Pathways & Interactions for NDUFC1 Gene

genes like me logo Genes that share pathways with NDUFC1: view

Interacting Proteins for NDUFC1 Gene

Selected Interacting proteins: O43677-NDUC1_HUMAN for NDUFC1 Gene via IID

Gene Ontology (GO) - Biological Process for NDUFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFC1: view

No data available for SIGNOR curated interactions for NDUFC1 Gene

Drugs & Compounds for NDUFC1 Gene

(1) Drugs for NDUFC1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra Target 0
genes like me logo Genes that share compounds with NDUFC1: view

Transcripts for NDUFC1 Gene

Unigene Clusters for NDUFC1 Gene

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFC1 Gene

No ASD Table

Relevant External Links for NDUFC1 Gene

GeneLoc Exon Structure for
NDUFC1
ECgene alternative splicing isoforms for
NDUFC1

Expression for NDUFC1 Gene

mRNA expression in normal human tissues for NDUFC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFC1 Gene

This gene is overexpressed in Nasal epithelium (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NDUFC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of NDUFC1 Gene:

NDUFC1

SOURCE GeneReport for Unigene cluster for NDUFC1 Gene:

Hs.84549
genes like me logo Genes that share expression patterns with NDUFC1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NDUFC1 Gene

Orthologs for NDUFC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NDUFC1 Gene

Organism Taxonomy Gene Similarity Type Details
rat
(Rattus norvegicus)
Mammalia Ndufc1 34
  • 82.02 (n)
cow
(Bos Taurus)
Mammalia NDUFC1 34 35
  • 81.14 (n)
mouse
(Mus musculus)
Mammalia Ndufc1 34 16 35
  • 79.39 (n)
dog
(Canis familiaris)
Mammalia NDUFC1 34 35
  • 77.19 (n)
oppossum
(Monodelphis domestica)
Mammalia NDUFC1 35
  • 66 (a)
OneToOne
Species where no ortholog for NDUFC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NDUFC1 Gene

ENSEMBL:
Gene Tree for NDUFC1 (if available)
TreeFam:
Gene Tree for NDUFC1 (if available)

Paralogs for NDUFC1 Gene

No data available for Paralogs for NDUFC1 Gene

Variants for NDUFC1 Gene

Sequence variations from dbSNP and Humsavar for NDUFC1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10003164 -- 139,296,482(+) CCTAA(C/T)AGACT intron-variant
rs111590660 -- 139,295,732(+) CTCAC(A/G)GCCGC reference, missense
rs111674171 -- 139,291,682(+) TAAAA(C/T)AGGTT intron-variant
rs111730025 -- 139,294,662(+) CCCGC(A/G)AGGCA intron-variant
rs112589640 -- 139,294,028(+) GCTCC(A/G)CCTCC intron-variant

Variation tolerance for NDUFC1 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFC1 Gene

Disorders for NDUFC1 Gene

Relevant External Links for NDUFC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFC1

No disorders were found for NDUFC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFC1 Gene

Publications for NDUFC1 Gene

  1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C. … Liew C.-C. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3 64
  5. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 64

Products for NDUFC1 Gene

Sources for NDUFC1 Gene

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