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Aliases for NDUFC1 Gene

Aliases for NDUFC1 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit C1 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 1, 6kDa 2 3
  • NADH-Ubiquinone Oxidoreductase KFYI Subunit 3 4
  • Complex I KFYI Subunit 2 3
  • Complex I-KFYI 3 4
  • CI-KFYI 3 4
  • NADH Dehydrogenase (Ubiquinone) 1, Subcomplex Unknown, 1 (6kD, KFYI) 2
  • KFYI 3

External Ids for NDUFC1 Gene

Previous GeneCards Identifiers for NDUFC1 Gene

  • GC04M141092
  • GC04M140510
  • GC04M140677
  • GC04M140788
  • GC04M140568
  • GC04M140430
  • GC04M140212
  • GC04M135941

Summaries for NDUFC1 Gene

Entrez Gene Summary for NDUFC1 Gene

  • The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for NDUFC1 Gene

NDUFC1 (NADH:Ubiquinone Oxidoreductase Subunit C1) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFC1 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFC1 Gene

Genomics for NDUFC1 Gene

Regulatory Elements for NDUFC1 Gene

Promoters for NDUFC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDUFC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDUFC1 Gene

Chromosome:
4
Start:
139,266,880 bp from pter
End:
139,302,551 bp from pter
Size:
35,672 bases
Orientation:
Minus strand

Genomic View for NDUFC1 Gene

Genes around NDUFC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFC1 Gene

Proteins for NDUFC1 Gene

  • Protein details for NDUFC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43677-NDUC1_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
    Protein Accession:
    O43677
    Secondary Accessions:
    • A8K532
    • Q3MIJ9

    Protein attributes for NDUFC1 Gene

    Size:
    76 amino acids
    Molecular mass:
    8734 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

neXtProt entry for NDUFC1 Gene

Proteomics data for NDUFC1 Gene at MOPED

Post-translational modifications for NDUFC1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NDUFC1 Gene

Domains & Families for NDUFC1 Gene

Protein Domains for NDUFC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFC1 Gene

Graphical View of Domain Structure for InterPro Entry

O43677

UniProtKB/Swiss-Prot:

NDUC1_HUMAN :
  • Belongs to the complex I NDUFC1 subunit family.
Family:
  • Belongs to the complex I NDUFC1 subunit family.
genes like me logo Genes that share domains with NDUFC1: view

Function for NDUFC1 Gene

Molecular function for NDUFC1 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),6kDa,subcomplex unkknown,1
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
genes like me logo Genes that share phenotypes with NDUFC1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NDUFC1 Gene

Localization for NDUFC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFC1 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFC1 Gene COMPARTMENTS Subcellular localization image for NDUFC1 gene
Compartment Confidence
mitochondrion 5

No data available for Gene Ontology (GO) - Cellular Components for NDUFC1 Gene

Pathways & Interactions for NDUFC1 Gene

genes like me logo Genes that share pathways with NDUFC1: view

Interacting Proteins for NDUFC1 Gene

Gene Ontology (GO) - Biological Process for NDUFC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
genes like me logo Genes that share ontologies with NDUFC1: view

No data available for SIGNOR curated interactions for NDUFC1 Gene

Drugs & Compounds for NDUFC1 Gene

(1) Drugs for NDUFC1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra Target 0
genes like me logo Genes that share compounds with NDUFC1: view

Transcripts for NDUFC1 Gene

Unigene Clusters for NDUFC1 Gene

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFC1 Gene

No ASD Table

Relevant External Links for NDUFC1 Gene

GeneLoc Exon Structure for
NDUFC1
ECgene alternative splicing isoforms for
NDUFC1

Expression for NDUFC1 Gene

mRNA expression in normal human tissues for NDUFC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFC1 Gene

This gene is overexpressed in Nasal epithelium (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NDUFC1 Gene



SOURCE GeneReport for Unigene cluster for NDUFC1 Gene Hs.84549

genes like me logo Genes that share expression patterns with NDUFC1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NDUFC1 Gene

Orthologs for NDUFC1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NDUFC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFC1 35
  • 81.14 (n)
  • 78.95 (a)
NDUFC1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFC1 36
  • 71 (a)
OneToOne
NDUFC1 35
  • 77.19 (n)
  • 76.32 (a)
mouse
(Mus musculus)
Mammalia Ndufc1 35
  • 79.39 (n)
  • 75 (a)
Ndufc1 16
Ndufc1 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFC1 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufc1 35
  • 82.02 (n)
  • 77.63 (a)
Species with no ortholog for NDUFC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NDUFC1 Gene

ENSEMBL:
Gene Tree for NDUFC1 (if available)
TreeFam:
Gene Tree for NDUFC1 (if available)

Paralogs for NDUFC1 Gene

No data available for Paralogs for NDUFC1 Gene

Variants for NDUFC1 Gene

Sequence variations from dbSNP and Humsavar for NDUFC1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6833101 -- 139,299,404(+) ATTTT(A/C)TTTCT intron-variant
rs6826290 -- 139,292,340(+) CCCCA(C/T)CCCCC intron-variant
rs7654022 -- 139,294,575(+) ACCAA(A/C)AATAC intron-variant
rs10003164 -- 139,296,482(+) CCTAA(C/T)AGACT intron-variant
rs11731550 -- 139,297,697(+) ACAGT(A/G)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFC1 Gene

Variant ID Type Subtype PubMed ID
nsv880160 CNV Gain 21882294

Variation tolerance for NDUFC1 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFC1 Gene

HapMap Linkage Disequilibrium report
NDUFC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFC1 Gene

Disorders for NDUFC1 Gene

Relevant External Links for NDUFC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFC1

No disorders were found for NDUFC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFC1 Gene

Publications for NDUFC1 Gene

  1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C. … Liew C.-C. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 67
  2. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25

Products for NDUFC1 Gene

Sources for NDUFC1 Gene

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