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Aliases for NDUFB9 Gene

Aliases for NDUFB9 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B9 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 9, 22kDa 2 3
  • NADH-Ubiquinone Oxidoreductase B22 Subunit 3 4
  • LYR Motif-Containing Protein 3 3 4
  • Complex I B22 Subunit 2 3
  • CI-B22 3 4
  • UQOR22 3 4
  • LYRM3 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 9 (22kD, B22) 2
  • Complex I-B22 4
  • B22 3

External Ids for NDUFB9 Gene

Previous GeneCards Identifiers for NDUFB9 Gene

  • GC08P124713
  • GC08P125555
  • GC08P125220
  • GC08P125507
  • GC08P125620
  • GC08P120876
  • GC08P125551

Summaries for NDUFB9 Gene

Entrez Gene Summary for NDUFB9 Gene

  • The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for NDUFB9 Gene

NDUFB9 (NADH:Ubiquinone Oxidoreductase Subunit B9) is a Protein Coding gene. Diseases associated with NDUFB9 include mitochondrial complex i deficiency and osgood-schlatter's disease. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB9 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB9 Gene

Genomics for NDUFB9 Gene

Regulatory Elements for NDUFB9 Gene

Promoters for NDUFB9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDUFB9 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDUFB9 Gene

Chromosome:
8
Start:
124,539,102 bp from pter
End:
124,568,510 bp from pter
Size:
29,409 bases
Orientation:
Plus strand

Genomic View for NDUFB9 Gene

Genes around NDUFB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB9 Gene

Proteins for NDUFB9 Gene

  • Protein details for NDUFB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M9-NDUB9_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
    Protein Accession:
    Q9Y6M9
    Secondary Accessions:
    • B2R8M6
    • Q9UQE8

    Protein attributes for NDUFB9 Gene

    Size:
    179 amino acids
    Molecular mass:
    21831 Da
    Quaternary structure:
    • Mammalian complex I is composed of 45 different subunits.

neXtProt entry for NDUFB9 Gene

Proteomics data for NDUFB9 Gene at MOPED

Post-translational modifications for NDUFB9 Gene

  • Ubiquitination at Lys 15
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFB9 Gene

Antibody Products

No data available for DME Specific Peptides for NDUFB9 Gene

Domains & Families for NDUFB9 Gene

Protein Domains for NDUFB9 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFB9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y6M9

UniProtKB/Swiss-Prot:

NDUB9_HUMAN :
  • Belongs to the complex I LYR family.
Family:
  • Belongs to the complex I LYR family.
genes like me logo Genes that share domains with NDUFB9: view

Function for NDUFB9 Gene

Molecular function for NDUFB9 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),22kDa,component beta 9,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation,(OXPHOS),inner mitochondrial membrane,homologous to bovine subunit,B22
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
genes like me logo Genes that share phenotypes with NDUFB9: view

Human Phenotype Ontology for NDUFB9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NDUFB9 Gene

Localization for NDUFB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB9 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB9 Gene COMPARTMENTS Subcellular localization image for NDUFB9 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NDUFB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NDUFB9: view

Pathways & Interactions for NDUFB9 Gene

genes like me logo Genes that share pathways with NDUFB9: view

Interacting Proteins for NDUFB9 Gene

Gene Ontology (GO) - Biological Process for NDUFB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with NDUFB9: view

No data available for SIGNOR curated interactions for NDUFB9 Gene

Drugs & Compounds for NDUFB9 Gene

(5) Drugs for NDUFB9 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFB9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFB9: view

Transcripts for NDUFB9 Gene

Unigene Clusters for NDUFB9 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: - -

Relevant External Links for NDUFB9 Gene

GeneLoc Exon Structure for
NDUFB9
ECgene alternative splicing isoforms for
NDUFB9

Expression for NDUFB9 Gene

mRNA expression in normal human tissues for NDUFB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFB9 Gene

This gene is overexpressed in Muscle - Skeletal (x4.7).

Protein differential expression in normal tissues from HIPED for NDUFB9 Gene

This gene is overexpressed in Heart (9.4), Nasal epithelium (7.3), and Frontal cortex (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB9 Gene



SOURCE GeneReport for Unigene cluster for NDUFB9 Gene Hs.15977

genes like me logo Genes that share expression patterns with NDUFB9: view

Protein tissue co-expression partners for NDUFB9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NDUFB9 Gene

Orthologs for NDUFB9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFB9 35
  • 88.45 (n)
  • 91.06 (a)
NDUFB9 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB9 35
  • 88.83 (n)
  • 90.5 (a)
NDUFB9 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufb9 35
  • 86.7 (n)
  • 87.08 (a)
Ndufb9 16
Ndufb9 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDUFB9 35
  • 99.81 (n)
  • 99.44 (a)
NDUFB9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb9 35
  • 86.33 (n)
  • 86.52 (a)
oppossum
(Monodelphis domestica)
Mammalia NDUFB9 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB9 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFB9 35
  • 77.84 (n)
  • 79.19 (a)
NDUFB9 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB9 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb9 35
  • 76.25 (n)
  • 80.46 (a)
Str.5819 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.4627 35
zebrafish
(Danio rerio)
Actinopterygii ndufb9 35
  • 74.14 (n)
  • 78.16 (a)
wufb10b03 35
ndufb9 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10507 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009865 35
  • 56.59 (n)
  • 50.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9306 35
  • 54.57 (n)
  • 48.39 (a)
CG9306 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C16A3.5 35
  • 46.28 (n)
  • 36.69 (a)
C16A3.5 36
  • 31 (a)
OneToOne
Species with no ortholog for NDUFB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFB9 Gene

ENSEMBL:
Gene Tree for NDUFB9 (if available)
TreeFam:
Gene Tree for NDUFB9 (if available)

Paralogs for NDUFB9 Gene

(1) SIMAP similar genes for NDUFB9 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NDUFB9 Gene

genes like me logo Genes that share paralogs with NDUFB9: view

No data available for Paralogs for NDUFB9 Gene

Variants for NDUFB9 Gene

Sequence variations from dbSNP and Humsavar for NDUFB9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10195 - 124,549,788(-) ACCAG(A/C/G)TGGCG reference, missense
rs3829038 -- 124,549,514(-) CTTCC(C/T)CCTAC intron-variant
rs4377948 -- 124,544,527(+) tgtta(C/G)ggact intron-variant
rs4871499 -- 124,541,925(+) ttgtt(G/T)ttttt intron-variant
rs6987343 -- 124,547,566(+) gttgt(A/C)atgac intron-variant

Variation tolerance for NDUFB9 Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFB9 Gene

HapMap Linkage Disequilibrium report
NDUFB9
Human Gene Mutation Database (HGMD)
NDUFB9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFB9 Gene

Disorders for NDUFB9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NDUFB9 Gene - From: OMIM, ClinVar, and DISEASES

Disorder Aliases PubMed IDs
mitochondrial complex i deficiency
  • mitochondrial complex 1 deficiency
osgood-schlatter's disease
  • osteochondrosis
balanitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NDUFB9

Genetic Association Database (GAD)
NDUFB9
Human Genome Epidemiology (HuGE) Navigator
NDUFB9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFB9
genes like me logo Genes that share disorders with NDUFB9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDUFB9 Gene

Publications for NDUFB9 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The human B22 subunit of the NADH-ubiquinone oxidoreductase maps to the region of chromosome 8 involved in branchio-oto-renal syndrome. (PMID: 8661098) Gu J.Z. … Wells D.E. (Genomics 1996) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3

Products for NDUFB9 Gene

Sources for NDUFB9 Gene

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