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Aliases for NDUFB9 Gene

Aliases for NDUFB9 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 9, 22kDa 2 3
  • UQOR22 3 4 6
  • NADH-Ubiquinone Oxidoreductase B22 Subunit 3 4
  • LYR Motif-Containing Protein 3 3 4
  • Complex I B22 Subunit 2 3
  • Complex I-B22 3 4
  • CI-B22 3 4
  • LYRM3 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 9 (22kD, B22) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 9 3
  • B22 3

External Ids for NDUFB9 Gene

Summaries for NDUFB9 Gene

GeneCards Summary for NDUFB9 Gene

NDUFB9 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 9, 22kDa) is a Protein Coding gene. Diseases associated with NDUFB9 include mitochondrial complex i deficiency. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB9 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB9 Gene

Genomics for NDUFB9 Gene

Genomic Location for NDUFB9 Gene

Start:
124,539,102 bp from pter
End:
124,568,510 bp from pter
Size:
29,409 bases
Orientation:
Plus strand

Genomic View for NDUFB9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB9 Gene

Regulatory Elements for NDUFB9 Gene

Proteins for NDUFB9 Gene

  • Protein details for NDUFB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M9-NDUB9_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9
    Protein Accession:
    Q9Y6M9
    Secondary Accessions:
    • B2R8M6
    • Q9UQE8

    Protein attributes for NDUFB9 Gene

    Size:
    179 amino acids
    Molecular mass:
    21831 Da
    Quaternary structure:
    • Mammalian complex I is composed of 45 different subunits.

neXtProt entry for NDUFB9 Gene

Proteomics data for NDUFB9 Gene at MOPED

Post-translational modifications for NDUFB9 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys15

Other Protein References for NDUFB9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB9 Gene

Domains for NDUFB9 Gene

Gene Families for NDUFB9 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I
  • LYRM :LYR motif containing

Protein Domains for NDUFB9 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NDUB9_HUMAN
Family:
  • Belongs to the complex I LYR family.:
    • Q9Y6M9
genes like me logo Genes that share domains with NDUFB9: view

Function for NDUFB9 Gene

Molecular function for NDUFB9 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),22kDa,component beta 9,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation,(OXPHOS),inner mitochondrial membrane,homologous to bovine subunit,B22
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB9: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NDUFB9 Gene

Localization for NDUFB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB9 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB9 Gene COMPARTMENTS Subcellular localization image for NDUFB9 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NDUFB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NDUFB9: view

Pathways for NDUFB9 Gene

genes like me logo Genes that share pathways with NDUFB9: view

Interacting Proteins for NDUFB9 Gene

Gene Ontology (GO) - Biological Process for NDUFB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0007605 sensory perception of sound TAS 8661098
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB9: view

Compounds for NDUFB9 Gene

(8) HMDB Compounds for NDUFB9 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB9 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB9: view

Transcripts for NDUFB9 Gene

Unigene Clusters for NDUFB9 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB9 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3: - -
SP4: -
SP5:
SP6: - -

Relevant External Links for NDUFB9 Gene

GeneLoc Exon Structure for
NDUFB9
ECgene alternative splicing isoforms for
NDUFB9

Expression for NDUFB9 Gene

mRNA expression in normal human tissues for NDUFB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFB9 Gene

This gene is overexpressed in Muscle - Skeletal (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB9 Gene

SOURCE GeneReport for Unigene cluster for NDUFB9 Gene Hs.15977

genes like me logo Genes that share expressions with NDUFB9: view

Orthologs for NDUFB9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB9 36
  • 99.81 (n)
  • 99.44 (a)
NDUFB9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB9 36
  • 88.45 (n)
  • 91.06 (a)
NDUFB9 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB9 36
  • 88.83 (n)
  • 90.5 (a)
NDUFB9 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufb9 36
  • 86.7 (n)
  • 87.08 (a)
Ndufb9 16
Ndufb9 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB9 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB9 37
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb9 36
  • 86.33 (n)
  • 86.52 (a)
chicken
(Gallus gallus)
Aves NDUFB9 36
  • 77.84 (n)
  • 79.19 (a)
NDUFB9 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB9 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4627 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb9 36
  • 76.25 (n)
  • 80.46 (a)
Str.5819 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10507 36
zebrafish
(Danio rerio)
Actinopterygii ndufb9 36
  • 74.14 (n)
  • 78.16 (a)
ndufb9 37
  • 78 (a)
OneToOne
wufb10b03 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009865 36
  • 56.59 (n)
  • 50.39 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9306 36
  • 54.57 (n)
  • 48.39 (a)
CG9306 37
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C16A3.5 36
  • 46.28 (n)
  • 36.69 (a)
C16A3.5 37
  • 31 (a)
OneToOne
Species with no ortholog for NDUFB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFB9 Gene

ENSEMBL:
Gene Tree for NDUFB9 (if available)
TreeFam:
Gene Tree for NDUFB9 (if available)

Paralogs for NDUFB9 Gene

Selected SIMAP similar genes for NDUFB9 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NDUFB9 Gene

genes like me logo Genes that share paralogs with NDUFB9: view

No data available for Paralogs for NDUFB9 Gene

Variants for NDUFB9 Gene

Sequence variations from dbSNP and Humsavar for NDUFB9 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10195 Benign, - 124,549,788(-) ACCAG(A/C/G)TGGCG reference, missense
rs3829038 -- 124,549,514(-) CTTCC(C/T)CCTAC intron-variant
rs4377948 -- 124,544,527(+) tgtta(C/G)ggact intron-variant
rs4871499 -- 124,541,925(+) ttgtt(G/T)ttttt intron-variant
rs6987343 -- 124,547,566(+) gttgt(A/C)atgac intron-variant

Relevant External Links for NDUFB9 Gene

HapMap Linkage Disequilibrium report
NDUFB9
Human Gene Mutation Database (HGMD)
NDUFB9

No data available for Structural Variations from Database of Genomic Variants (DGV) for NDUFB9 Gene

Disorders for NDUFB9 Gene

(1) OMIM Diseases for NDUFB9 Gene (601445)

(1) University of Copenhagen DISEASES for NDUFB9 Gene

Relevant External Links for NDUFB9

Genetic Association Database (GAD)
NDUFB9
Human Genome Epidemiology (HuGE) Navigator
NDUFB9
genes like me logo Genes that share disorders with NDUFB9: view

No data available for UniProtKB/Swiss-Prot for NDUFB9 Gene

Publications for NDUFB9 Gene

  1. The human B22 subunit of the NADH-ubiquinone oxidoreductase maps to the region of chromosome 8 involved in branchio-oto-renal syndrome. (PMID: 8661098) Gu J.Z. … Wells D.E. (Genomics 1996) 2 3
  2. Human NDUFB9 gene: genomic organization and a possible candidate gene associated with deafness disorder mapped to chromosome 8q13. (PMID: 10077726) Lin X. … Kumar S. (Hum. Hered. 1999) 3 4
  3. cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs. (PMID: 10944468) Ye Z. … Connor J.R. (Biochem. Biophys. Res. Commun. 2000) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NDUFB9 Gene

Sources for NDUFB9 Gene

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