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Aliases for NDUFB8 Gene

Aliases for NDUFB8 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B8 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8, 19kDa 2 3
  • Complex I ASHI Subunit 2 3
  • Complex I-ASHI 3 4
  • CI-ASHI 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 8, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8 (19kD, ASHI) 2
  • NADH:Ubiquinone Oxidoreductase ASHI Subunit 3
  • NADH-Ubiquinone Oxidoreductase ASHI Subunit 4
  • ASHI 3

External Ids for NDUFB8 Gene

Previous GeneCards Identifiers for NDUFB8 Gene

  • GC10M101140
  • GC10M101517
  • GC10M102414
  • GC10M101948
  • GC10M102273
  • GC10M095912

Summaries for NDUFB8 Gene

GeneCards Summary for NDUFB8 Gene

NDUFB8 (NADH:Ubiquinone Oxidoreductase Subunit B8) is a Protein Coding gene. Diseases associated with NDUFB8 include Epicondylitis and Hordeolum. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity. An important paralog of this gene is ENSG00000255339.

UniProtKB/Swiss-Prot for NDUFB8 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB8 Gene

Additional gene information for NDUFB8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB8 Gene

Genomics for NDUFB8 Gene

Regulatory Elements for NDUFB8 Gene

Enhancers for NDUFB8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H100369 1.8 FANTOM5 ENCODE dbSUPER 10.5 +157.6 157557 6 MLX FEZF1 DMAP1 YY1 ZNF548 SP3 NFYC MEF2D GLIS1 NBN ENSG00000231188 PHBP9 SEC31B HIF1AN EBAG9P1 SPCS2P2 TPM4P1 LOC101927300 SCD CHUK
GH10H100481 1.2 Ensembl ENCODE 11.1 +47.6 47576 1 ATF1 ARID4B GLI4 BRCA1 ZNF2 ZNF121 GLIS2 ZNF143 FOS SP3 SEC31B MRPL43 ENSG00000255339 NDUFB8 HIF1AN SLC25A28 LZTS2 LOC105378452 GC10M100500
GH10H100339 1.2 Ensembl ENCODE dbSUPER 10.1 +190.7 190722 0 CTCF FOXA2 RAD21 CC2D1A FOXK2 EED ZNF143 RUNX3 IKZF2 GATAD2A PKD2L1 SEC31B HIF1AN NDUFB8 ENSG00000255339 ENSG00000231188 BLOC1S2
GH10H100433 1 Ensembl 10.4 +96.3 96299 0 HDGF ATF1 ARNT SIN3A SLC30A9 ZNF143 ATF7 SP3 REST MIER2 SCD ENSG00000231188 WNT8B SEC31B ENSG00000255339 HIF1AN NDUFB8 ENSG00000212325
GH10H100434 1 ENCODE 10.4 +96.0 96042 0 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 SLC30A9 ZNF143 ATF7 DEK SEC31B ENSG00000231188 SCD WNT8B ENSG00000255339 HIF1AN NDUFB8 ENSG00000212325
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NDUFB8 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFB8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032517 500 1401 PKNOX1 ATF1 ZFP64 SIN3A DMAP1 YY1 ETS1 ZNF143 ATF7 RUNX3

Genomic Location for NDUFB8 Gene

Chromosome:
10
Start:
100,523,729 bp from pter
End:
100,530,000 bp from pter
Size:
6,272 bases
Orientation:
Minus strand

Genomic View for NDUFB8 Gene

Genes around NDUFB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB8 Gene

Proteins for NDUFB8 Gene

  • Protein details for NDUFB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95169-NDUB8_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
    Protein Accession:
    O95169
    Secondary Accessions:
    • A8K0L4
    • Q5W143
    • Q5W144
    • Q5W145
    • Q9UG53
    • Q9UJR4
    • Q9UQF3

    Protein attributes for NDUFB8 Gene

    Size:
    186 amino acids
    Molecular mass:
    21766 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB8 Gene

Post-translational modifications for NDUFB8 Gene

  • Ubiquitination at Lys34
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFB8 Gene

No data available for DME Specific Peptides for NDUFB8 Gene

Domains & Families for NDUFB8 Gene

Gene Families for NDUFB8 Gene

Protein Domains for NDUFB8 Gene

Graphical View of Domain Structure for InterPro Entry

O95169

UniProtKB/Swiss-Prot:

NDUB8_HUMAN :
  • Belongs to the complex I NDUFB8 subunit family.
Family:
  • Belongs to the complex I NDUFB8 subunit family.
genes like me logo Genes that share domains with NDUFB8: view

Function for NDUFB8 Gene

Molecular function for NDUFB8 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),21.8kDa,component beta 8,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Phenotypes From GWAS Catalog for NDUFB8 Gene

Gene Ontology (GO) - Molecular Function for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS,IEA 9878551
genes like me logo Genes that share ontologies with NDUFB8: view
genes like me logo Genes that share phenotypes with NDUFB8: view

Animal Models for NDUFB8 Gene

MGI Knock Outs for NDUFB8:

Animal Model Products

CRISPR Products

miRNA for NDUFB8 Gene

miRTarBase miRNAs that target NDUFB8

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NDUFB8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDUFB8 Gene

Localization for NDUFB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB8 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFB8 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 4
extracellular 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS,IMP 9878551
GO:0005783 endoplasmic reticulum IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDUFB8: view

Pathways & Interactions for NDUFB8 Gene

genes like me logo Genes that share pathways with NDUFB8: view

Gene Ontology (GO) - Biological Process for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB8: view

No data available for SIGNOR curated interactions for NDUFB8 Gene

Drugs & Compounds for NDUFB8 Gene

(1) Drugs for NDUFB8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra Target 0
genes like me logo Genes that share compounds with NDUFB8: view

Transcripts for NDUFB8 Gene

Unigene Clusters for NDUFB8 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NDUFB8
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - -
SP11: - - - -
SP12: -
SP13: -

Relevant External Links for NDUFB8 Gene

GeneLoc Exon Structure for
NDUFB8
ECgene alternative splicing isoforms for
NDUFB8

Expression for NDUFB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDUFB8 Gene

Protein differential expression in normal tissues from HIPED for NDUFB8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2) and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFB8 Gene



Protein tissue co-expression partners for NDUFB8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFB8 Gene:

NDUFB8

SOURCE GeneReport for Unigene cluster for NDUFB8 Gene:

Hs.523215

Evidence on tissue expression from TISSUES for NDUFB8 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Blood(4.4)
  • Intestine(3.4)
  • Pancreas(3.4)
  • Muscle(3.3)
  • Skin(3)
  • Heart(2.9)
  • Kidney(2.8)
  • Liver(2.7)
  • Eye(2.4)
  • Stomach(2.4)
  • Gall bladder(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with NDUFB8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFB8 Gene

Orthologs for NDUFB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB8 34 33
  • 99.64 (n)
OneToMany
cow
(Bos Taurus)
Mammalia NDUFB8 33
  • 87.63 (n)
-- 34
  • 53 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NDUFB8 33
  • 87.1 (n)
-- 34
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ndufb8 33
  • 86.92 (n)
mouse
(Mus musculus)
Mammalia Ndufb8 16 34 33
  • 84.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves NDUFB8 33 34
  • 68.12 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb8 33
  • 66.67 (n)
Str.15125 33
zebrafish
(Danio rerio)
Actinopterygii ndufb8 33 34
  • 64.7 (n)
zgc77718 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9112 33
fruit fly
(Drosophila melanogaster)
Insecta CG3192 33 34
  • 47.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002020 33
  • 46.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4923 34
  • 29 (a)
OneToMany
Species where no ortholog for NDUFB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB8 Gene

ENSEMBL:
Gene Tree for NDUFB8 (if available)
TreeFam:
Gene Tree for NDUFB8 (if available)

Paralogs for NDUFB8 Gene

Paralogs for NDUFB8 Gene

Pseudogenes.org Pseudogenes for NDUFB8 Gene

genes like me logo Genes that share paralogs with NDUFB8: view

Variants for NDUFB8 Gene

Sequence variations from dbSNP and Humsavar for NDUFB8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000314319 -- 100,527,149(+) ATAGA(C/T)GAGAA intron-variant
rs1000645379 -- 100,528,807(+) AACCA(C/T)TGGGA intron-variant
rs1000941200 -- 100,527,602(+) GTCTG(A/G)AAAAA intron-variant
rs1001527503 -- 100,527,615(+) AAAAC(A/C)AAACA intron-variant
rs1002011999 -- 100,530,692(+) CATTC(C/T)CAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NDUFB8 Gene

Variant ID Type Subtype PubMed ID
esv2759779 CNV gain+loss 17122850
esv3624363 CNV loss 21293372
nsv7519 CNV insertion 18451855
nsv831962 CNV gain 17160897
nsv831963 CNV loss 17160897

Variation tolerance for NDUFB8 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFB8 Gene

Human Gene Mutation Database (HGMD)
NDUFB8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB8 Gene

Disorders for NDUFB8 Gene

MalaCards: The human disease database

(5) MalaCards diseases for NDUFB8 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
epicondylitis
  • andrel epicondylitis
hordeolum
  • boil of eyelid
myofascial pain syndrome
  • myofascial pain dysfunction syndrome
breast abscess
  • abscess of breast
periarthritis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NDUFB8

Genetic Association Database (GAD)
NDUFB8
Human Genome Epidemiology (HuGE) Navigator
NDUFB8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFB8
genes like me logo Genes that share disorders with NDUFB8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDUFB8 Gene

Publications for NDUFB8 Gene

  1. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 60
  2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 45 60
  3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 45 60
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 45 60
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 60

Products for NDUFB8 Gene

Sources for NDUFB8 Gene

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