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Aliases for NDUFB8 Gene

Aliases for NDUFB8 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8, 19kDa 2 3
  • NADH-Ubiquinone Oxidoreductase ASHI Subunit 3 4
  • Complex I ASHI Subunit 2 3
  • Complex I-ASHI 3 4
  • CI-ASHI 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 8, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8 (19kD, ASHI) 2
  • NADH:Ubiquinone Oxidoreductase ASHI Subunit 3
  • ASHI 3

External Ids for NDUFB8 Gene

Summaries for NDUFB8 Gene

GeneCards Summary for NDUFB8 Gene

NDUFB8 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8, 19kDa) is a Protein Coding gene. Diseases associated with NDUFB8 include epicondylitis and myofascial pain syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is ENSG00000255339.

UniProtKB/Swiss-Prot for NDUFB8 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB8 Gene

Genomics for NDUFB8 Gene

Genomic Location for NDUFB8 Gene

Start:
100,523,729 bp from pter
End:
100,530,000 bp from pter
Size:
6,272 bases
Orientation:
Minus strand

Genomic View for NDUFB8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB8 Gene

Regulatory Elements for NDUFB8 Gene

Proteins for NDUFB8 Gene

  • Protein details for NDUFB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95169-NDUB8_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
    Protein Accession:
    O95169
    Secondary Accessions:
    • A8K0L4
    • Q5W143
    • Q5W144
    • Q5W145
    • Q9UG53
    • Q9UJR4
    • Q9UQF3

    Protein attributes for NDUFB8 Gene

    Size:
    186 amino acids
    Molecular mass:
    21766 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB8 Gene

Proteomics data for NDUFB8 Gene at MOPED

Post-translational modifications for NDUFB8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys34

Other Protein References for NDUFB8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB8 Gene

Domains for NDUFB8 Gene

Gene Families for NDUFB8 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB8 Gene

UniProtKB/Swiss-Prot:

NDUB8_HUMAN
Family:
  • Belongs to the complex I NDUFB8 subunit family.:
    • O95169
genes like me logo Genes that share domains with NDUFB8: view

Function for NDUFB8 Gene

Molecular function for NDUFB8 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),21.8kDa,component beta 8,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003954 NADH dehydrogenase activity --
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB8: view

Phenotypes for NDUFB8 Gene

MGI mutant phenotypes for NDUFB8:
inferred from 1 alleles
GenomeRNAi human phenotypes for NDUFB8:
genes like me logo Genes that share phenotypes with NDUFB8: view

miRNA for NDUFB8 Gene

miRTarBase miRNAs that target NDUFB8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFB8 Gene

Localization for NDUFB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB8 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB8 Gene COMPARTMENTS Subcellular localization image for NDUFB8 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 4
extracellular 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0005783 endoplasmic reticulum IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDUFB8: view

Pathways for NDUFB8 Gene

genes like me logo Genes that share pathways with NDUFB8: view

Gene Ontology (GO) - Biological Process for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0055114 oxidation-reduction process --
genes like me logo Genes that share ontologies with NDUFB8: view

Compounds for NDUFB8 Gene

(8) HMDB Compounds for NDUFB8 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB8 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB8: view

Transcripts for NDUFB8 Gene

Unigene Clusters for NDUFB8 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - -
SP11: - - - -
SP12: -
SP13: -

Relevant External Links for NDUFB8 Gene

GeneLoc Exon Structure for
NDUFB8
ECgene alternative splicing isoforms for
NDUFB8

Expression for NDUFB8 Gene

mRNA expression in normal human tissues for NDUFB8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB8 Gene

SOURCE GeneReport for Unigene cluster for NDUFB8 Gene Hs.523215

genes like me logo Genes that share expressions with NDUFB8: view

Orthologs for NDUFB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB8 36
  • 99.64 (n)
  • 99.46 (a)
NDUFB8 37
  • 99 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 53 (a)
OneToMany
NDUFB8 36
  • 87.63 (n)
  • 84.86 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 84 (a)
OneToMany
NDUFB8 36
  • 87.1 (n)
  • 83.87 (a)
mouse
(Mus musculus)
Mammalia Ndufb8 36
  • 84.23 (n)
  • 81.18 (a)
Ndufb8 16
Ndufb8 37
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ndufb8 36
  • 86.92 (n)
  • 83.33 (a)
chicken
(Gallus gallus)
Aves NDUFB8 36
  • 68.12 (n)
  • 69.02 (a)
NDUFB8 37
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb8 36
  • 66.67 (n)
  • 68.54 (a)
Str.15125 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9112 36
zebrafish
(Danio rerio)
Actinopterygii ndufb8 36
  • 64.7 (n)
  • 66.13 (a)
ndufb8 37
  • 65 (a)
OneToMany
zgc77718 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002020 36
  • 46.67 (n)
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3192 36
  • 47.92 (n)
  • 37.5 (a)
CG3192 37
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4923 37
  • 29 (a)
OneToMany
Species with no ortholog for NDUFB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB8 Gene

ENSEMBL:
Gene Tree for NDUFB8 (if available)
TreeFam:
Gene Tree for NDUFB8 (if available)

Paralogs for NDUFB8 Gene

Paralogs for NDUFB8 Gene

Pseudogenes.org Pseudogenes for NDUFB8 Gene

genes like me logo Genes that share paralogs with NDUFB8: view

Variants for NDUFB8 Gene

Sequence variations from dbSNP and Humsavar for NDUFB8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1800662 -- 100,529,321(+) CCACC(A/C)AACCC intron-variant
rs1802224 -- 100,526,494(-) CTGTT(A/C/T)CTTGG missense, reference
rs3179689 -- 100,523,741(-) TGTGT(A/T)ATTTG utr-variant-3-prime
rs4603237 -- 100,529,231(+) CCCCT(C/T)CCACC intron-variant
rs4919468 -- 100,528,586(+) GCTAA(C/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB8 Gene

Variant ID Type Subtype PubMed ID
essv24916 CNV CNV 17122850
nsv831962 CNV Gain 17160897
dgv811n71 CNV Loss 21882294
nsv831963 CNV Loss 17160897
nsv895957 CNV Gain 21882294
nsv7519 CNV Insertion 18451855

Relevant External Links for NDUFB8 Gene

HapMap Linkage Disequilibrium report
NDUFB8

Disorders for NDUFB8 Gene

(4) University of Copenhagen DISEASES for NDUFB8 Gene

Relevant External Links for NDUFB8

Genetic Association Database (GAD)
NDUFB8
Human Genome Epidemiology (HuGE) Navigator
NDUFB8
genes like me logo Genes that share disorders with NDUFB8: view

No data available for UniProtKB/Swiss-Prot for NDUFB8 Gene

Publications for NDUFB8 Gene

  1. In situ hybridisation mapping of genomic clones for five human respiratory chain complex I genes. (PMID: 9345899) Dunbar D.R. … Brookes A.J. (Cytogenet. Cell Genet. 1997) 3 23
  2. Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping. (PMID: 9763676) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  3. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 3 4
  4. Identification of 167 polymorphisms in 88 genes from candidate neurodegeneration pathways. (PMID: 10570959) Emahazion T. … Brookes J.A. (Gene 1999) 3 4
  5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4

Products for NDUFB8 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Alzheimers Disease in human,mouse,rat
    • Mitochondrial Energy Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDUFB8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB8
    • Block miRNA regulation of NDUFB8 using miScript Target Protectors

    Sources for NDUFB8 Gene

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