Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NDUFB8 Gene

Aliases for NDUFB8 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B8 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8, 19kDa 2 3
  • Complex I ASHI Subunit 2 3
  • Complex I-ASHI 3 4
  • CI-ASHI 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 8, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8 (19kD, ASHI) 2
  • NADH:Ubiquinone Oxidoreductase ASHI Subunit 3
  • NADH-Ubiquinone Oxidoreductase ASHI Subunit 4
  • ASHI 3

External Ids for NDUFB8 Gene

Previous GeneCards Identifiers for NDUFB8 Gene

  • GC10M101140
  • GC10M101517
  • GC10M102414
  • GC10M101948
  • GC10M102273
  • GC10M095912

Summaries for NDUFB8 Gene

GeneCards Summary for NDUFB8 Gene

NDUFB8 (NADH:Ubiquinone Oxidoreductase Subunit B8) is a Protein Coding gene. Diseases associated with NDUFB8 include Breast Abscess and Hordeolum. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and GABAergic synapse. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity. An important paralog of this gene is ENSG00000255339.

UniProtKB/Swiss-Prot for NDUFB8 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB8 Gene

Genomics for NDUFB8 Gene

Regulatory Elements for NDUFB8 Gene

Enhancers for NDUFB8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G100369 1.9 FANTOM5 ENCODE dbSUPER 10.5 +157.6 157557 6.8 CREB3L1 MLX AGO1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 PHBP9 SEC31B EBAG9P1 ENSG00000231188 SCD ENSG00000272572 CHUK TWNK ENSG00000255339 HIF1AN
GH10G100481 1.3 Ensembl ENCODE 11.1 +47.6 47576 2.0 PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 ZNF143 FOS ZNF263 SP3 NFYC SEC31B ENSG00000272572 HIF1AN ENSG00000255339 NDUFB8 LOC105378452 GC10M100500
GH10G100339 1.2 Ensembl ENCODE dbSUPER 10.1 +190.7 190722 1.0 SOX5 GATAD2A CTCF BHLHE40 TRIM22 DPF2 TBX21 RAD21 FOXA1 FOXK2 PKD2L1 SEC31B HIF1AN ENSG00000255339 NDUFB8 ENSG00000231188 BLOC1S2
GH10G100434 1 ENCODE 10.4 +96.0 96042 0.2 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 SLC30A9 ZNF143 DEK SEC31B SCD ENSG00000231188 WNT8B ENSG00000255339 HIF1AN NDUFB8 ENSG00000273030
GH10G100338 1 ENCODE dbSUPER 10.1 +191.4 191372 0.2 CTCF FOXA2 ARNT ARID4B RAD21 RFX5 FOXK2 ZNF143 ZNF207 SMC3 SEC31B ENSG00000255339 HIF1AN NDUFB8 ENSG00000231188 BLOC1S2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NDUFB8 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFB8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032517 500 1401 PKNOX1 ATF1 ZFP64 WRNIP1 SIN3A DMAP1 YY1 ETS1 ZNF121 DEK

Genomic Location for NDUFB8 Gene

Chromosome:
10
Start:
100,523,729 bp from pter
End:
100,530,000 bp from pter
Size:
6,272 bases
Orientation:
Minus strand

Genomic View for NDUFB8 Gene

Genes around NDUFB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB8 Gene

Proteins for NDUFB8 Gene

  • Protein details for NDUFB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95169-NDUB8_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial
    Protein Accession:
    O95169
    Secondary Accessions:
    • A8K0L4
    • Q5W143
    • Q5W144
    • Q5W145
    • Q9UG53
    • Q9UJR4
    • Q9UQF3

    Protein attributes for NDUFB8 Gene

    Size:
    186 amino acids
    Molecular mass:
    21766 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB8 Gene

Post-translational modifications for NDUFB8 Gene

  • Ubiquitination at Lys34
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFB8 Gene

No data available for DME Specific Peptides for NDUFB8 Gene

Domains & Families for NDUFB8 Gene

Protein Domains for NDUFB8 Gene

Graphical View of Domain Structure for InterPro Entry

O95169

UniProtKB/Swiss-Prot:

NDUB8_HUMAN :
  • Belongs to the complex I NDUFB8 subunit family.
Family:
  • Belongs to the complex I NDUFB8 subunit family.
genes like me logo Genes that share domains with NDUFB8: view

Function for NDUFB8 Gene

Molecular function for NDUFB8 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),21.8kDa,component beta 8,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS,IEA 9878551
genes like me logo Genes that share ontologies with NDUFB8: view
genes like me logo Genes that share phenotypes with NDUFB8: view

Animal Models for NDUFB8 Gene

MGI Knock Outs for NDUFB8:

Animal Model Products

CRISPR Products

miRNA for NDUFB8 Gene

miRTarBase miRNAs that target NDUFB8

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDUFB8 Gene

Localization for NDUFB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB8 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFB8 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 4
extracellular 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0005783 endoplasmic reticulum IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDUFB8: view

Pathways & Interactions for NDUFB8 Gene

genes like me logo Genes that share pathways with NDUFB8: view

Gene Ontology (GO) - Biological Process for NDUFB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB8: view

No data available for SIGNOR curated interactions for NDUFB8 Gene

Drugs & Compounds for NDUFB8 Gene

(1) Drugs for NDUFB8 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra Target 0
genes like me logo Genes that share compounds with NDUFB8: view

Transcripts for NDUFB8 Gene

Unigene Clusters for NDUFB8 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - -
SP11: - - - -
SP12: -
SP13: -

Relevant External Links for NDUFB8 Gene

GeneLoc Exon Structure for
NDUFB8
ECgene alternative splicing isoforms for
NDUFB8

Expression for NDUFB8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDUFB8 Gene

Protein differential expression in normal tissues from HIPED for NDUFB8 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2) and Bone (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFB8 Gene



Protein tissue co-expression partners for NDUFB8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFB8 Gene:

NDUFB8

SOURCE GeneReport for Unigene cluster for NDUFB8 Gene:

Hs.523215

Evidence on tissue expression from TISSUES for NDUFB8 Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Blood(4.4)
  • Intestine(3.4)
  • Pancreas(3.4)
  • Muscle(3.3)
  • Skin(3)
  • Heart(2.9)
  • Kidney(2.8)
  • Liver(2.7)
  • Eye(2.4)
  • Stomach(2.4)
  • Gall bladder(2.2)
  • Adrenal gland(2)
genes like me logo Genes that share expression patterns with NDUFB8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFB8 Gene

Orthologs for NDUFB8 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB8 34 35
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia NDUFB8 34
  • 87.63 (n)
-- 35
  • 53 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NDUFB8 34
  • 87.1 (n)
-- 35
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ndufb8 34
  • 86.92 (n)
mouse
(Mus musculus)
Mammalia Ndufb8 34 16 35
  • 84.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves NDUFB8 34 35
  • 68.12 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 63 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb8 34
  • 66.67 (n)
Str.15125 34
zebrafish
(Danio rerio)
Actinopterygii ndufb8 34 35
  • 64.7 (n)
zgc77718 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9112 34
fruit fly
(Drosophila melanogaster)
Insecta CG3192 34 35
  • 47.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002020 34
  • 46.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4923 35
  • 29 (a)
OneToMany
Species where no ortholog for NDUFB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB8 Gene

ENSEMBL:
Gene Tree for NDUFB8 (if available)
TreeFam:
Gene Tree for NDUFB8 (if available)

Paralogs for NDUFB8 Gene

Paralogs for NDUFB8 Gene

Pseudogenes.org Pseudogenes for NDUFB8 Gene

genes like me logo Genes that share paralogs with NDUFB8: view

Variants for NDUFB8 Gene

Sequence variations from dbSNP and Humsavar for NDUFB8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000314319 -- 100,527,149(+) ATAGA(C/T)GAGAA intron-variant
rs1000645379 -- 100,528,807(+) AACCA(C/T)TGGGA intron-variant
rs1000941200 -- 100,527,602(+) GTCTG(A/G)AAAAA intron-variant
rs1001527503 -- 100,527,615(+) AAAAC(A/C)AAACA intron-variant
rs1002011999 -- 100,530,692(+) CATTC(C/T)CAAGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NDUFB8 Gene

Variant ID Type Subtype PubMed ID
esv2759779 CNV gain+loss 17122850
esv3624363 CNV loss 21293372
nsv7519 CNV insertion 18451855
nsv831962 CNV gain 17160897
nsv831963 CNV loss 17160897

Variation tolerance for NDUFB8 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFB8 Gene

Human Gene Mutation Database (HGMD)
NDUFB8
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB8 Gene

Disorders for NDUFB8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NDUFB8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast abscess
  • abscess of breast
hordeolum
  • hordeolum externum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NDUFB8

Genetic Association Database (GAD)
NDUFB8
Human Genome Epidemiology (HuGE) Navigator
NDUFB8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFB8
genes like me logo Genes that share disorders with NDUFB8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDUFB8 Gene

Publications for NDUFB8 Gene

  1. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 46 64
  2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 46 64
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NDUFB8 Gene

Sources for NDUFB8 Gene

Content
Loading form....