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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDUFB8 Gene

protein-coding   GIFtS: 60
GCID: GC10M102273

NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8, 19kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 (19kD,...)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8, 19kDa1 2     NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8 (19kD, ASHI)1
Complex I ASHI Subunit1 2     ASHI2
Complex I-ASHI2 3     NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 8, Mitochondrial2
CI-ASHI2 3     NADH:Ubiquinone Oxidoreductase ASHI Subunit2
NADH-Ubiquinone Oxidoreductase ASHI Subunit2 3     

External Ids:    HGNC: 77031   Entrez Gene: 47142   Ensembl: ENSG000001661367   OMIM: 6021405   UniProtKB: O951693   

Export aliases for NDUFB8 gene to outside databases

Previous GC identifers: GC10M101140 GC10M101517 GC10M102414 GC10M101948 GC10M095912


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NDUFB8 Gene: 
NDUFB8 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa) is a protein-coding gene. Diseases associated with NDUFB8 include myofascial pain syndrome, and epicondylitis, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is ENSG00000255339.

UniProtKB/Swiss-Prot: NDUB8_HUMAN, O95169
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDUFB8 gene promoter:
         RP58   AML1a   AP-1   IRF-7A   MIF-1   CUTL1   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFB8 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDUFB8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.31

NDUFB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFB8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M102273:  view genomic region     (about GC identifiers)

Start:
102,267,203 bp from pter      End:
102,289,757 bp from pter
Size:
22,555 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDUB8_HUMAN, O95169 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor  
Size: 186 amino acids; 21766 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
Secondary accessions: A8K0L4 Q5W144 Q9UG53 Q9UJR4 Q9UQF3

Explore the universe of human proteins at neXtProt for NDUFB8: NX_O95169

Explore proteomics data for NDUFB8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95169

  • NDUFB8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDUFB8 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001271296.1  NP_001271297.1  NP_004995.1  

    ENSEMBL proteins: 
     ENSP00000299166   ENSP00000359346   ENSP00000359344   ENSP00000434072   ENSP00000433145  
    Reactome Protein details: O95169
    Human Recombinant Protein Products for NDUFB8: 
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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0005783endoplasmic reticulum IDA--
    GO:0016021integral to membrane IEA--

    NDUFB8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comI: Mitochondrial respiratory chain complex / Complex I

    2 InterPro protein domains:
     IPR016551 NADH_UbQ_OxRdtase_b-cplx_su8
     IPR008699 NADH_UbQ_OxRdtase_ASHI_su

    Graphical View of Domain Structure for InterPro Entry O95169

    ProtoNet protein and cluster: O95169

    1 Blocks protein domain: IPB008699 NADH-ubiquinone oxidoreductase ASHI subunit

    UniProtKB/Swiss-Prot: NDUB8_HUMAN, O95169
    Similarity: Belongs to the complex I NDUFB8 subunit family


    NDUFB8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUB8_HUMAN, O95169
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Genatlas biochemistry entry for NDUFB8:
    NADH ubiquinone oxidoreductase (Q reductase),21.8kDa,component beta 8,hydrophobic fraction of the complex I
    multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003954NADH dehydrogenase activity ----
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    NDUFB8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for NDUFB8:
     Decreased influenza A virus in  Wnt reporter downregulated 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDUFB8 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.47
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Alzheimer's disease0.46
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFB8
        Electron Transport Chain
    Oxidative phosphorylation

    4        Reactome Pathways for NDUFB8
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/6         Kegg Pathways  (Kegg details for NDUFB8) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFB8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for NDUFB8 (O951692, 3 ENSP000002991664) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFN2P350802, 3MINT-65721 I2D: score=5 
    PIM2Q9P1W92, 3, ENSP000003656924MINT-65723 I2D: score=5 STRING: ENSP00000365692
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    EIF2B3Q9NR503, ENSP000003535754I2D: score=4 STRING: ENSP00000353575
    CACNA1AO005553I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFB8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDUFB8 (NDUB8)

    8 HMDB Compounds for NDUFB8    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFB8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about NDUFB8 / NDUB8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDUFB8 gene (3 alternative transcripts): 
    NM_001284367.1  NM_001284368.1  NM_005004.3  

    Unigene Cluster for NDUFB8:

    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
    Hs.523215  [show with all ESTs]
    Unigene Representative Sequence: BM923464
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464651 ENST00000299166(uc001kri.1) ENST00000370322 ENST00000370320
    ENST00000528425 ENST00000466088 ENST00000529437 ENST00000531418 ENST00000531189
    ENST00000531258(uc010qpr.1)

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    Additional mRNA sequence: 

    AF044958.1 AF077028.1 AF115968.1 AK289579.1 AL080056.1 BC000466.2 BC019276.1 CR533490.1 

    21 DOTS entries:

    DT.100882012  DT.92004038  DT.219482  DT.100882019  DT.121302797  DT.92449513  DT.121302705  DT.91897842 
    DT.100638412  DT.121302726  DT.121302800  DT.120922388  DT.100882005  DT.121302754  DT.121302755  DT.121302791 
    DT.95179757  DT.121302793  DT.87011974  DT.92449508  DT.121302789 

    24/681 AceView cDNA sequences (see all 681):

    CF130685 BE263214 AI369318 CF129550 BQ637747 CF130426 CD109020 BM826589 
    CA437932 BU179777 BM698269 BM796007 CB133368 BM765816 CB106993 BQ068922 
    AA975789 CF129581 AL042767 CF129749 BM827605 CB113848 CR592473 CF130051 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB8 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                          -     -           -     -                 -     -           -     -     -     -                     
    SP2:                                -           -     -                 -     -           -     -     -     -                     
    SP3:                                -                 -                 -     -           -     -                                 
    SP4:                                -           -     -                 -     -           -     -                                 
    SP5:                                -                 -                 -     -           -     -     -     -                     


    ECgene alternative splicing isoforms for NDUFB8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDUFB8 expression in normal human tissues (normalized intensities)      NDUFB8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGGGTGG
    NDUFB8 Expression
    About this image


    NDUFB8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
             brain/midbrain   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             sensory organ/ear/inner ear   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Eye (Sensory Organs)
             Retina
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   

    See NDUFB8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDUFB8

    SOURCE GeneReport for Unigene cluster: Hs.523215
        SABiosciences Expression via Pathway-Focused PCR Arrays including NDUFB8: 
              Mitochondrial Energy Metabolism in human mouse rat
              Alzheimer's Disease in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NDUFB8 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufb81 , 5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 81, 5 84.23(n)1
    81.18(a)1
      19 (37.98 cM)5
    672641  NM_026061.21  NP_080337.11 
     445485725 
    chicken
    (Gallus gallus)
    Aves NDUFB81 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 67.93(n)
    69.02(a)
      423763  NM_001006502.1  NP_001006502.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    62(a)
    1 → many
    GL343388.1(251132-260400)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA982851.12   -- 73.3(n)    CA982851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc777182 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 74.41(n)   393829  BC062842.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG31921 CG3192 50(n)
    40.3(a)
      31604  NM_001031877.1  NP_001027048.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y51H1A.36
    Protein Y51H1A.3, isoform a
    22(a)
    1 → many
    II(13872869-13875423)


    ENSEMBL Gene Tree for NDUFB8 (if available)
    TreeFam Gene Tree for NDUFB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDUFB8 gene
    ENSG000002553392  

    NDUFB8 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for NDUFB8
    PGOHUM00000248226 PGOHUM00000237449 PGOHUM00000237515


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/198 SNPs in NDUFB8 are shown (see all 198)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406161341,2
    --102283023(+) ACAGGC/TGCGCA 1 -- ds50010--------
    rs1504505241,2
    --102283025(+) AGGCGC/TGCACT 1 -- ds50010--------
    rs1491624651,2
    --102283098(+) AGGCTA/GGTCTC 1 -- ds50010--------
    rs1141452491,2
    F--102283278(+) GGACCC/TTTAAC 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1856017121,2
    --102283329(+) AAGTGA/CAATTA 1 -- ds50010--------
    rs1883514791,2
    --102283395(+) ATTTCA/GGAAAA 1 -- ds50010--------
    rs1450333551,2
    C,F--102283642(+) TCACCG/ACCTCG 2 /G syn11Minor allele frequency- A:0.01NA 4550
    rs2015448131,2
    --102283718(+) GAACAC/TACATT 1 -- int10--------
    rs1388692921,2
    --102283743(+) CTACAC/TCCCAC 1 -- int10--------
    rs1809987351,2
    --102283765(+) AATCAC/TGCATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NDUFB8 (102267203 - 102289757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NDUFB8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv7519CNV Insertion18451855
    dgv811n71CNV Loss21882294
    nsv831963CNV Loss17160897
    nsv831962CNV Gain17160897
    nsv895957CNV Gain21882294
    essv24916CNV CNV17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602140    OMIM disorders: --

    14 diseases for NDUFB8:    About MalaCards
    myofascial pain syndrome    epicondylitis    spondylosis    herpes zoster
    paine syndrome    gout    huntington's disease    macular degeneration
    cervical cancer    parkinson's disease    ataxia    cervicitis
    alzheimer's disease    prostatitis

    4 diseases from the University of Copenhagen DISEASES database for NDUFB8:
    Epicondylitis     Herpes zoster     Spondylosis     Myofascial pain syndrome

    NDUFB8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NDUFB8
    Human Genome Epidemiology (HuGE) Navigator: NDUFB8 (3 documents)

    Export disorders for NDUFB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDUFB8 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with NDUFB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    2. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (2008)
    3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
    6. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    9. Identification of 167 polymorphisms in 88 genes from candidate neurodegeneration pathways. (PubMed id 10570959)1, 2 Emahazion T.... Brookes J.A. (1999)
    10. Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping. (PubMed id 9763676)1, 3 Emahazion T. and Brookes A.J. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4714 HGNC: 7703 AceView: NDUFB8andSEC31L2 Ensembl:ENSG00000166136 euGenes: HUgn4714
    ECgene: NDUFB8 Kegg: 4714 H-InvDB: NDUFB8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDUFB8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDUFB8 gene:
    Search GeneIP for patents involving NDUFB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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