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NDUFB8 Gene

protein-coding   GIFtS: 61
GCID: GC10M102273

NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8, 19kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 (19kD,...)
  See NDUFB8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8, 19kDa1 2     NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 8 (19kD, ASHI)1
Complex I ASHI Subunit1 2     ASHI2
Complex I-ASHI2 3     NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 8, Mitochondrial2
CI-ASHI2 3     NADH:Ubiquinone Oxidoreductase ASHI Subunit2
NADH-Ubiquinone Oxidoreductase ASHI Subunit2 3     

External Ids:    HGNC: 77031   Entrez Gene: 47142   Ensembl: ENSG000001661367   OMIM: 6021405   UniProtKB: O951693   

Export aliases for NDUFB8 gene to outside databases

Previous GC identifers: GC10M101140 GC10M101517 GC10M102414 GC10M101948 GC10M095912


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NDUFB8 Gene:
NDUFB8 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa) is a protein-coding gene. Diseases associated with NDUFB8 include epicondylitis, and myofascial pain syndrome. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is ENSG00000255339.

UniProtKB/Swiss-Prot: NDUB8_HUMAN, O95169
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFB8 gene promoter:
         RP58   AML1a   AP-1   IRF-7A   MIF-1   CUTL1   Tal-1beta   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFB8 promoter sequence
   Search Chromatin IP Primers for NDUFB8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.31   Ensembl cytogenetic band:  10q24.31   HGNC cytogenetic band: 10q24.31

NDUFB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFB8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M102273:  view genomic region     (about GC identifiers)

Start:
102,267,203 bp from pter      End:
102,289,757 bp from pter
Size:
22,555 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NDUB8_HUMAN, O95169 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor  
Size: 186 amino acids; 21766 Da
Subunit: Complex I is composed of 45 different subunits
Secondary accessions: A8K0L4 Q5W144 Q9UG53 Q9UJR4 Q9UQF3

Explore the universe of human proteins at neXtProt for NDUFB8: NX_O95169

Explore proteomics data for NDUFB8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys34
  • Modification sites at PhosphoSitePlus

  • See NDUFB8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001271296.1  NP_001271297.1  NP_004995.1  

    ENSEMBL proteins: 
     ENSP00000299166   ENSP00000359346   ENSP00000359344   ENSP00000434072   ENSP00000433145  
    Reactome Protein details: O95169

    NDUFB8 Human Recombinant Protein Products:

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    antibodies-online peptides for NDUFB8

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    2 InterPro protein domains:
     IPR016551 NADH_UbQ_OxRdtase_b-cplx_su8
     IPR008699 NDUFB8

    Graphical View of Domain Structure for InterPro Entry O95169

    ProtoNet protein and cluster: O95169

    1 Blocks protein domain: IPB008699 NADH-ubiquinone oxidoreductase ASHI subunit

    UniProtKB/Swiss-Prot: NDUB8_HUMAN, O95169
    Similarity: Belongs to the complex I NDUFB8 subunit family


    Find genes that share domains with NDUFB8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUB8_HUMAN, O95169
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Genatlas biochemistry entry for NDUFB8:
    NADH ubiquinone oxidoreductase (Q reductase),21.8kDa,component beta 8,hydrophobic fraction of the complex I
    multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003954NADH dehydrogenase activity ----
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    Find genes that share ontologies with NDUFB8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NDUFB8:
     Decreased influenza A virus in  Wnt reporter downregulated 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ndufb8):
     mortality/aging 

    Find genes that share phenotypes with NDUFB8           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NDUFB8

    miRNA
    Products:
        
    miRTarBase miRNAs that target NDUFB8:
    hsa-mir-505-5p (MIRT037965)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDUB8_HUMAN, O95169: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    endoplasmic reticulum4
    extracellular2
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0005783endoplasmic reticulum IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with NDUFB8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDUFB8 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44


    Find genes that share SuperPaths with NDUFB8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFB8
        Oxidative phosphorylation
    Electron Transport Chain

    1 Reactome Pathway for NDUFB8
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for NDUFB8) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NDUFB8: 
              Mitochondrial Energy Metabolism in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFB8 (O951692, 3 ENSP000002991664) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PFN2P350802, 3MINT-65721 I2D: score=5 
    PIM2Q9P1W92, 3, ENSP000003656924MINT-65723 I2D: score=5 STRING: ENSP00000365692
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    EIF2B3Q9NR503, ENSP000003535754I2D: score=4 STRING: ENSP00000353575
    CACNA1AO005553I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with NDUFB8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFB8 (NDUB8)

    8 HMDB Compounds for NDUFB8    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFB8    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDUFB8 gene (3 alternative transcripts): 
    NM_001284367.1  NM_001284368.1  NM_005004.3  

    Unigene Cluster for NDUFB8:

    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
    Hs.523215  [show with all ESTs]
    Unigene Representative Sequence: BM923464
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464651 ENST00000299166(uc001kri.1) ENST00000370322 ENST00000370320
    ENST00000528425 ENST00000466088 ENST00000529437 ENST00000531418 ENST00000531189
    ENST00000531258(uc010qpr.1)
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      QuantiFast Probe-based Assays in human, mouse, rat NDUFB8

    Additional mRNA sequence: 

    AF044958.1 AF077028.1 AF115968.1 AK289579.1 AL080056.1 BC000466.2 BC019276.1 CR533490.1 

    21 DOTS entries:

    DT.100882012  DT.92004038  DT.219482  DT.100882019  DT.121302797  DT.92449513  DT.121302705  DT.91897842 
    DT.100638412  DT.121302726  DT.121302800  DT.120922388  DT.100882005  DT.121302754  DT.121302755  DT.121302791 
    DT.95179757  DT.121302793  DT.87011974  DT.92449508  DT.121302789 

    Selected AceView cDNA sequences (see all 681):

    BQ639033 CF130406 BQ213736 AI581663 AW204793 AL080141 AI199771 AK093637 
    AA731551 BQ056202 BM703916 AF279139 AA953792 BC019276 BM553550 CA777692 
    BP347387 BM853119 BM314721 W93494 CK824041 AW575542 CA435234 BQ933170 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB8 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                          -     -           -     -                 -     -           -     -     -     -                     
    SP2:                                -           -     -                 -     -           -     -     -     -                     
    SP3:                                -                 -                 -     -           -     -                                 
    SP4:                                -           -     -                 -     -           -     -                                 
    SP5:                                -                 -                 -     -           -     -     -     -                     


    ECgene alternative splicing isoforms for NDUFB8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDUFB8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGGGTGG
    NDUFB8 Expression
    About this image


    NDUFB8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Eye (Sensory Organs)
             Lens
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
    NDUFB8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFB8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523215
        Pathway & Disease-focused RT2 Profiler PCR Arrays including NDUFB8: 
              Mitochondrial Energy Metabolism in human mouse rat
              Alzheimer's Disease in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDUFB8 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufb81 , 5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 81, 5 84.23(n)1
    81.18(a)1
      19 (37.98 cM)5
    672641  NM_026061.21  NP_080337.11 
     445485725 
    chicken
    (Gallus gallus)
    Aves NDUFB81 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 68.12(n)
    69.02(a)
      423763  NM_001006502.1  NP_001006502.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    63(a)
    1 → many
    GL343388.1(251132-260400)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA982851.12   -- 73.3(n)    CA982851.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc777182 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 74.41(n)   393829  BC062842.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG31921 CG3192 47.92(n)
    37.5(a)
      31604  NM_001031877.1  NP_001027048.1 


    ENSEMBL Gene Tree for NDUFB8 (if available)
    TreeFam Gene Tree for NDUFB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDUFB8 gene
    ENSG000002553392  

    Find genes that share paralogs with NDUFB8           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for NDUFB8
    PGOHUM00000248226 PGOHUM00000237449 PGOHUM00000237515


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for NDUFB8 (see all 198)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406161341,2
    --102283023(+) ACAGGC/TGCGCA 1 -- ds50010--------
    rs1504505241,2
    --102283025(+) AGGCGC/TGCACT 1 -- ds50010--------
    rs1491624651,2
    --102283098(+) AGGCTA/GGTCTC 1 -- ds50010--------
    rs1141452491,2
    F--102283278(+) GGACCC/TTTAAC 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs1856017121,2
    --102283329(+) AAGTGA/CAATTA 1 -- ds50010--------
    rs1883514791,2
    --102283395(+) ATTTCA/GGAAAA 1 -- ds50010--------
    rs1450333551,2
    C,F--102283642(+) TCACCG/ACCTCG 2 /G syn11Minor allele frequency- A:0.01NA 4550
    rs2015448131,2
    --102283718(+) GAACAC/TACATT 1 -- int10--------
    rs1388692921,2
    --102283743(+) CTACAC/TCCCAC 1 -- int10--------
    rs1809987351,2
    --102283765(+) AATCAC/TGCATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NDUFB8 (102267203 - 102289757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NDUFB8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7519CNV Insertion18451855
    dgv811n71CNV Loss21882294
    nsv831963CNV Loss17160897
    nsv831962CNV Gain17160897
    nsv895957CNV Gain21882294
    essv24916CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFB8
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFB8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602140    OMIM disorders: --

    3 diseases for NDUFB8:    
    About MalaCards
    epicondylitis    myofascial pain syndrome    spondylosis

    4 diseases from the University of Copenhagen DISEASES database for NDUFB8:
    Epicondylitis     Herpes zoster     Spondylosis     Myofascial pain syndrome

    Find genes that share disorders with NDUFB8           About GenesLikeMe

    Genetic Association Database (GAD): NDUFB8
    Human Genome Epidemiology (HuGE) Navigator: NDUFB8 (3 documents)

    Export disorders for NDUFB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDUFB8 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with NDUFB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    3. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    9. Identification of 167 polymorphisms in 88 genes from candidate neurodegeneration pathways. (PubMed id 10570959)1, 2 Emahazion T.... Brookes J.A. (Gene 1999)
    10. Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping. (PubMed id 9763676)1, 3 Emahazion T. and Brookes A.J. (Cytogenet. Cell Genet. 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4714 HGNC: 7703 AceView: NDUFB8andSEC31L2 Ensembl:ENSG00000166136 euGenes: HUgn4714
    ECgene: NDUFB8 Kegg: 4714 H-InvDB: NDUFB8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NDUFB8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDUFB8 gene:
    Search GeneIP for patents involving NDUFB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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