NDUFB7 Gene
protein-coding GIFtS: 55
GCID: GC19M014676
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|
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 (18kD,...)
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Aliases
for NDUFB7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 7, 18kDa1 2 | | NADH-Ubiquinone Oxidoreductase B18 Subunit2 3 | | CI-B181 2 3 | | MGC24801 | | B181 2 | | NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 7 (18kD, B18)1 | | Cell Adhesion Protein SQM12 3 | | Complex I B18 Subunit2 | | Complex I-B182 3 | | NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 72 |
Export aliases for NDUFB7 gene to outside databasesPrevious GC identifers: GC19M015031 GC19M014522 GC19M014537 GC19M014246 |
Summaries
for NDUFB7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NDUFB7:
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammaliancomplex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein hasNADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain.The immediate electron acceptor for the enzyme is believed to be ubiquinone. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: NDUB7_HUMAN, P17568Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Wiki entry for NDUFB7
|
Genomic Views
for NDUFB7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDUFB7 gene promoter:
RFX1 AML1a Pbx1a STAT5A NF-kappaB GATA-1 PPAR-gamma1 PPAR-gamma2 ZID NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFB7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFB7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.12 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.12NDUFB7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M014676: view genomic region
(about GC identifiers)
Start:
|
14,676,890 bp from pter |
End:
|
14,682,886 bp from pter |
Size:
|
5,997 bases |
Orientation:
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minus strand |
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Proteins
for NDUFB7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NDUB7_HUMAN, P17568 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 Size: 137 amino acids; 16402 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein (Probable).Mitochondrion intermembrane space
Sequence caution: Sequence=AAA35675.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q6ICN9 Q9UI16Explore the universe of human proteins at neXtProt for NDUFB7: NX_P17568
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P17568
NDUFB7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004137.2
ENSEMBL proteins: ENSP00000215565 Reactome Protein details: P17568
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NDUFB7 for ontologies About GeneDecksing
NDUFB7 Antibody Products:
Assay Products for NDUFB7: |
Protein
Domains /
Families
for NDUFB7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NDUFB7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P17568ProtoNet protein and cluster: P17568 1 Blocks protein family: IPB008698 NADH-ubiquinone oxidoreductase B18 subunit
UniProtKB/Swiss-Prot: NDUB7_HUMAN, P17568Domain: Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation ofintramolecular disulfide bondsSimilarity: Belongs to the complex I NDUFB7 subunit family |
Function
for NDUFB7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NDUB7_HUMAN, P17568Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone Genatlas biochemistry entry for NDUFB7:NADH ubiquinone oxidoreductase (Q reductase),18kDa,component beta 7,hydrophobic fraction of the complex I multi-subunitenzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFB7
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
NAS | 9878551 |
NDUFB7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NDUFB7:
|
Pathways & Interactions
for NDUFB7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NDUFB7
4 
Reactome Pathways for NDUFB7
5 
Kegg Pathways (Kegg details for NDUFB7):
NDUFB7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFB7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/62 Interacting proteins for NDUFB7 (P175683 ENSP000002155654) via UniProtKB, MINT, STRING, and/or I2D (see all 62)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
NAS | 9878551 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
NDUFB7 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDUFB7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NDUFB7
8 HMDB Compounds for NDUFB7 About this table
1 DrugBank Compound for NDUFB7 About this table
Search CenterWatch for drugs/clinical trials and news about NDUFB7 / NDUB7
|
Transcripts
for NDUFB7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NDUFB7 gene: NM_004146.5 Unigene Cluster for NDUFB7: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa Hs.532853 [show with all ESTs]Unigene Representative Sequence: BG7459001 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000215565(uc002mzg.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFB7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFB7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NDUFB7 (NM_004146) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDUFB7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB7 |
Additional cDNA sequence: AF112200.1 AF217091.1 BC002595.2 CR450354.1 9 DOTS entries: DT.316326 DT.97771139 DT.95289999 DT.92430525 DT.100789989 DT.121456654 DT.95191564 DT.95289997 DT.121456655 24/192 AceView cDNA sequences (see all 192): AF112200 AV690992 BM665253 BU845475 BQ069996 BE504809 F37113 NM_004146 H50286 BQ070851 BQ064433 H18124 BQ668918 CR610926 AV689874 BX118330 AI810836 BC002595 AI253656 BM725710 BM705074 AA528220 CR450354 BM705164
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB7 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | | | | | | |
ECgene alternative splicing isoforms for NDUFB7
|
Expression
for NDUFB7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDUFB7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGGAGTTTG
About this image
See NDUFB7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDUFB7
SOURCE GeneReport for Unigene cluster: Hs.532853
SABiosciences Expression via Pathway-Focused PCR Array including NDUFB7:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFB7
Browse OriGene validated miRNA SYBR primer pairs
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Orthologs
for NDUFB7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NDUFB7 gene from 8/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ndufb71 , 5 |
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more1, 5 |
82.97(n)1
82.48(a)1 |
|
8 (40.22 cM)5
669161 NM_025843.31 NP_080119.11
835666715 |
lizard
(Anolis carolinensis) |
Reptilia |
NDUFB76 |
-- |
74(a) |
1 ↔ 1 |
2(102756101-102761150) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.319092 |
Xenopus laevis transcribed sequence with weak similarity more |
73.77(n) |
|
AW640203.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc778202 |
hypothetical protein MGC77820 |
73.37(n) |
|
393821 BC062284.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG55481 |
CG5548 |
62.54(n)
54.29(a) |
|
32434 NM_132765.1 NP_572993.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
D2030.41 |
Protein D2030.4 |
50.14(n)
52.1(a) |
|
172513 NM_059718.3 NP_492119.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT2G020506 |
putative NADH-ubiquinone oxidoreductase B18 subuni... |
29(a) |
1 ↔ 1 |
2(489966-491995) |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
27(a) |
1 ↔ 1 |
3(1684483-1688536) |
ENSEMBL Gene Tree for NDUFB7 (if available)
TreeFam Gene Tree for NDUFB7 (if available) |
Paralogs
for NDUFB7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NDUFB7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NDUFB7 (14676890 - 14682886 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NDUFB7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFB7 |
|
Disorders
/ Diseases
for NDUFB7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDUFB7 for disorders About GeneDecksing
OMIM gene information: 603842
OMIM disorders: --
5  diseases for NDUFB7: About MalaCardsintrahepatic cholangiocarcinoma huntington's disease cholangiocarcinoma parkinson's disease
carcinoma
Human Genome Epidemiology (HuGE) Navigator: NDUFB7 (5 documents)
Export disorders for NDUFB7 gene to outside databases
|
Publications
for NDUFB7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NDUFB7 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with NDUFB7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the human complex I NDUFB7 and 17.2-kDa cDNAs and mutational analysis of 19 genes of the HP fraction in complex I-deficient-patients. (PubMed id 10830904)1, 2, 3 Triepels R....van den Heuvel L. (2000)
- NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I. (PubMed id 21310150)1, 2 Szklarczyk R....Huynen M.A. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (1998)
- cDNA cloning of a novel cell adhesion protein expressed in human squamous carcinoma cells. (PubMed id 2302251)1, 2 Wong Y.-C.... Bernal S.D. (1990)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for NDUFB7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDUFB7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFB7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFB7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NDUFB7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NDUFB7 gene:
Search GeneIP for patents involving NDUFB7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDUFB7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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