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Aliases for NDUFB7 Gene

Aliases for NDUFB7 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 7, 18kDa 2 3
  • NADH-Ubiquinone Oxidoreductase B18 Subunit 2 3 4
  • Cell Adhesion Protein SQM1 3 4
  • Complex I B18 Subunit 2 3
  • Complex I-B18 3 4
  • CI-B18 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 7 (18kD, B18) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 7 3
  • B18 3

External Ids for NDUFB7 Gene

Previous GeneCards Identifiers for NDUFB7 Gene

  • GC19M015031
  • GC19M014522
  • GC19M014676
  • GC19M014246

Summaries for NDUFB7 Gene

Entrez Gene Summary for NDUFB7 Gene

  • The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]

GeneCards Summary for NDUFB7 Gene

NDUFB7 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 7, 18kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB7 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB7 Gene

Genomics for NDUFB7 Gene

Regulatory Elements for NDUFB7 Gene

Genomic Location for NDUFB7 Gene

Start:
14,566,078 bp from pter
End:
14,572,077 bp from pter
Size:
6,000 bases
Orientation:
Minus strand

Genomic View for NDUFB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB7 Gene

Proteins for NDUFB7 Gene

  • Protein details for NDUFB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17568-NDUB7_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
    Protein Accession:
    P17568
    Secondary Accessions:
    • Q6ICN9
    • Q9UI16

    Protein attributes for NDUFB7 Gene

    Size:
    137 amino acids
    Molecular mass:
    16402 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.
    SequenceCaution:
    • Sequence=AAA35675.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for NDUFB7 Gene

Proteomics data for NDUFB7 Gene at MOPED

Post-translational modifications for NDUFB7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFB7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB7 Gene

Domains for NDUFB7 Gene

Gene Families for NDUFB7 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB7 Gene

Suggested Antigen Peptide Sequences for NDUFB7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17568

UniProtKB/Swiss-Prot:

NDUB7_HUMAN :
  • P17568
Domain:
  • Contains two C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.
Family:
  • Belongs to the complex I NDUFB7 subunit family.
genes like me logo Genes that share domains with NDUFB7: view

Function for NDUFB7 Gene

Molecular function for NDUFB7 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),18kDa,component beta 7,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003954 NADH dehydrogenase activity --
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB7: view

Phenotypes for NDUFB7 Gene

GenomeRNAi human phenotypes for NDUFB7:
genes like me logo Genes that share phenotypes with NDUFB7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NDUFB7 Gene

Localization for NDUFB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB7 Gene

Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB7 Gene COMPARTMENTS Subcellular localization image for NDUFB7 gene
Compartment Confidence
mitochondrion 5
extracellular 2
nucleus 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NDUFB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I IDA 12611891
GO:0005758 mitochondrial intermembrane space IDA 21310150
genes like me logo Genes that share ontologies with NDUFB7: view

Pathways for NDUFB7 Gene

genes like me logo Genes that share pathways with NDUFB7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NDUFB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB7: view

Compounds for NDUFB7 Gene

(8) HMDB Compounds for NDUFB7 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB7: view

Transcripts for NDUFB7 Gene

mRNA/cDNA for NDUFB7 Gene

Unigene Clusters for NDUFB7 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for NDUFB7 Gene

GeneLoc Exon Structure for
NDUFB7
ECgene alternative splicing isoforms for
NDUFB7

Expression for NDUFB7 Gene

mRNA expression in normal human tissues for NDUFB7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB7 Gene

SOURCE GeneReport for Unigene cluster for NDUFB7 Gene Hs.532853

genes like me logo Genes that share expressions with NDUFB7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFB7 Gene

Orthologs for NDUFB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB7 35
  • 99.27 (n)
  • 99.26 (a)
NDUFB7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB7 35
  • 89.29 (n)
  • 86.86 (a)
NDUFB7 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB7 35
  • 87.1 (n)
  • 79.56 (a)
NDUFB7 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufb7 35
  • 82.97 (n)
  • 82.48 (a)
Ndufb7 16
Ndufb7 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB7 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb7 35
  • 82.24 (n)
  • 79.56 (a)
lizard
(Anolis carolinensis)
Reptilia NDUFB7 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.31909 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb7 35
  • 65.33 (n)
  • 65 (a)
Str.6434 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8778 35
zebrafish
(Danio rerio)
Actinopterygii ndufb7 35
  • 64.44 (n)
  • 60 (a)
ndufb7 36
  • 59 (a)
OneToOne
zgc77820 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007574 35
  • 56.11 (n)
  • 50.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5548 35
  • 62.27 (n)
  • 52.75 (a)
CG5548 36
  • 50 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea D2030.4 36
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5982 36
  • 35 (a)
OneToOne
Species with no ortholog for NDUFB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFB7 Gene

ENSEMBL:
Gene Tree for NDUFB7 (if available)
TreeFam:
Gene Tree for NDUFB7 (if available)

Paralogs for NDUFB7 Gene

No data available for Paralogs for NDUFB7 Gene

Variants for NDUFB7 Gene

Sequence variations from dbSNP and Humsavar for NDUFB7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9543 -- 14,571,992(-) GGGGC(C/G)CACCT reference, synonymous-codon
rs13018 -- 14,566,828(-) TGACA(A/G)CTTCC missense, reference
rs1609864 -- 14,572,478(-) AAAAA(A/C)AAAAA upstream-variant-2KB
rs2228463 -- 14,566,920(-) GCCAC(A/G)CAGCA reference, synonymous-codon
rs3049969 -- 14,567,407(-) GAGAG(-/AG)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB7 Gene

Variant ID Type Subtype PubMed ID
esv2678899 CNV Deletion 23128226

Relevant External Links for NDUFB7 Gene

HapMap Linkage Disequilibrium report
NDUFB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB7 Gene

Disorders for NDUFB7 Gene

Relevant External Links for NDUFB7

Genetic Association Database (GAD)
NDUFB7
Human Genome Epidemiology (HuGE) Navigator
NDUFB7
genes like me logo Genes that share disorders with NDUFB7: view

No data available for UniProtKB/Swiss-Prot for NDUFB7 Gene

Publications for NDUFB7 Gene

  1. Characterization of the human complex I NDUFB7 and 17.2-kDa cDNAs and mutational analysis of 19 genes of the HP fraction in complex I- deficient-patients. (PMID: 10830904) Triepels R. … van den Heuvel L. (Hum. Genet. 2000) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 48

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