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Aliases for NDUFB6 Gene

Aliases for NDUFB6 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 6, 17kDa 2 3
  • NADH-Ubiquinone Oxidoreductase B17 Subunit 2 3 4
  • Complex I-B17 3 4
  • CI-B17 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 6 (17kD, B17) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 6 3
  • Complex I, Mitochondrial Respiratory Chain, B17 Subunit 3
  • NADH-Ubiquinone Oxidoreductase Beta Subunit, 6 3
  • NADH-Ubiquinone Oxidoreductase Beta Subunit 2
  • Mitochondrial Respiratory Chain 2
  • B17 Subunit 2
  • Complex I 2
  • B17 3
  • CI 3
  • 6 2

External Ids for NDUFB6 Gene

Summaries for NDUFB6 Gene

Entrez Gene Summary for NDUFB6 Gene

  • The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus and three transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jan 2011]

GeneCards Summary for NDUFB6 Gene

NDUFB6 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 6, 17kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB6 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB6 Gene

Genomics for NDUFB6 Gene

Genomic Location for NDUFB6 Gene

Start:
32,552,999 bp from pter
End:
32,573,184 bp from pter
Size:
20,186 bases
Orientation:
Minus strand

Genomic View for NDUFB6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB6 Gene

Regulatory Elements for NDUFB6 Gene

Transcription factor binding sites by QIAGEN in the NDUFB6 gene promoter:

Proteins for NDUFB6 Gene

  • Protein details for NDUFB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95139-NDUB6_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6
    Protein Accession:
    O95139
    Secondary Accessions:
    • A8K0Y7
    • Q5VYT2
    • Q6IB84

    Protein attributes for NDUFB6 Gene

    Size:
    128 amino acids
    Molecular mass:
    15489 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB6 Gene

Proteomics data for NDUFB6 Gene at MOPED

Post-translational modifications for NDUFB6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys9, Lys49, Lys54, and Lys93

Other Protein References for NDUFB6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB6 Gene

Domains for NDUFB6 Gene

Gene Families for NDUFB6 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NDUB6_HUMAN
Family:
  • Belongs to the complex I NDUFB6 subunit family.:
    • O95139
genes like me logo Genes that share domains with NDUFB6: view

Function for NDUFB6 Gene

Molecular function for NDUFB6 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),17kDa,component beta 6,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB6: view

miRNA for NDUFB6 Gene

miRTarBase miRNAs that target NDUFB6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFB6 Gene

Localization for NDUFB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB6 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB6 Gene COMPARTMENTS Subcellular localization image for NDUFB6 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NDUFB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDUFB6: view

Pathways for NDUFB6 Gene

genes like me logo Genes that share pathways with NDUFB6: view

Gene Ontology (GO) - Biological Process for NDUFB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB6: view

Compounds for NDUFB6 Gene

(8) HMDB Compounds for NDUFB6 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB6: view

Transcripts for NDUFB6 Gene

Unigene Clusters for NDUFB6 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: - -
SP4:

Relevant External Links for NDUFB6 Gene

GeneLoc Exon Structure for
NDUFB6
ECgene alternative splicing isoforms for
NDUFB6

Expression for NDUFB6 Gene

mRNA expression in normal human tissues for NDUFB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB6 Gene

SOURCE GeneReport for Unigene cluster for NDUFB6 Gene Hs.493668

genes like me logo Genes that share expressions with NDUFB6: view

Orthologs for NDUFB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB6 36
  • 99.74 (n)
  • 100 (a)
NDUFB6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB6 36
  • 82.81 (n)
  • 78.12 (a)
NDUFB6 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB6 36
  • 84.9 (n)
  • 77.34 (a)
NDUFB6 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufb6 36
  • 77.6 (n)
  • 70.31 (a)
Ndufb6 16
Ndufb6 37
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB6 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB6 37
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb6 36
  • 78.65 (n)
  • 69.53 (a)
chicken
(Gallus gallus)
Aves NDUFB6 36
  • 60.94 (n)
  • 58.59 (a)
NDUFB6 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB6 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb6 36
  • 67.19 (n)
  • 65.62 (a)
zebrafish
(Danio rerio)
Actinopterygii ndufb6 36
  • 58.33 (n)
  • 54.69 (a)
ndufb6 37
  • 55 (a)
OneToOne
zgc73375 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5152 37
  • 26 (a)
OneToOne
Species with no ortholog for NDUFB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB6 Gene

ENSEMBL:
Gene Tree for NDUFB6 (if available)
TreeFam:
Gene Tree for NDUFB6 (if available)

Paralogs for NDUFB6 Gene

Pseudogenes.org Pseudogenes for NDUFB6 Gene

genes like me logo Genes that share paralogs with NDUFB6: view

No data available for Paralogs for NDUFB6 Gene

Variants for NDUFB6 Gene

Sequence variations from dbSNP and Humsavar for NDUFB6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs598349 -- 32,568,026(-) gtcac(C/T)caggc intron-variant
rs611653 -- 32,568,170(+) ggagg(A/T)ggtca intron-variant
rs621194 -- 32,574,279(-) AGATG(C/T)ATATA upstream-variant-2KB
rs621601 -- 32,574,339(-) ctgta(C/T)aaatt upstream-variant-2KB
rs629566 -- 32,573,604(-) GGGAC(A/G)GATGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NDUFB6 Gene

Variant ID Type Subtype PubMed ID
nsv831540 CNV Gain 17160897

Relevant External Links for NDUFB6 Gene

HapMap Linkage Disequilibrium report
NDUFB6
Human Gene Mutation Database (HGMD)
NDUFB6

Disorders for NDUFB6 Gene

Relevant External Links for NDUFB6

Genetic Association Database (GAD)
NDUFB6
Human Genome Epidemiology (HuGE) Navigator
NDUFB6
genes like me logo Genes that share disorders with NDUFB6: view

No data available for UniProtKB/Swiss-Prot for NDUFB6 Gene

Publications for NDUFB6 Gene

  1. Molecular characterization and mutational analysis of the human B17 subunit of the mitochondrial respiratory chain complex I. (PMID: 9760212) Smeitink J. … van den Heuvel L. (Hum. Genet. 1998) 2 3 4
  2. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for NDUFB6 Gene

Sources for NDUFB6 Gene

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