NDUFB6 Gene
protein-coding GIFtS: 54
GCID: GC09M032510
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NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 (17kD,...)
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Aliases
for NDUFB6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 6, 17kDa1 2 | | NADH-Ubiquinone Oxidoreductase B17 Subunit2 3 | | B171 2 | | NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 6 (17kD, B17)1 | | CI1 2 | | Complex I, Mitochondrial Respiratory Chain, B17 Subunit2 | | Complex I-B172 3 | | NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 62 | | CI-B172 3 | | NADH-Ubiquinone Oxidoreductase Beta Subunit, 62 |
Export aliases for NDUFB6 gene to outside databasesPrevious GC identifers: GC09M032865 GC09M032723 GC09M032543 |
Summaries
for NDUFB6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NDUFB6:
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammaliancomplex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADHdehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. Theimmediate electron acceptor for the enzyme is believed to be ubiquinone. Alternative splicing occurs at this locus andthree transcript variants encoding distinct isoforms have been identified. (provided by RefSeq, Jan 2011)
UniProtKB/Swiss-Prot: NDUB6_HUMAN, O95139Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Wiki entry for NDUFB6
|
Genomic Views
for NDUFB6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDUFB6 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFB6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFB6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p21.1 Ensembl cytogenetic band: 9p21.1 HGNC cytogenetic band: 9p13.2NDUFB6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M032510: view genomic region
(about GC identifiers)
Start:
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32,552,997 bp from pter |
End:
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32,573,182 bp from pter |
Size:
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20,186 bases |
Orientation:
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minus strand |
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Proteins
for NDUFB6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NDUB6_HUMAN, O95139 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 Size: 128 amino acids; 15489 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
Secondary accessions: A8K0Y7 Q5VYT2 Q6IB84Alternative splicing: 2 isoforms: O95139-1 O95139-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NDUFB6: NX_O95139
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95139
NDUFB6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001186916.1 NP_002484.1 NP_877416.1
ENSEMBL proteins: ENSP00000369176 ENSP00000297983 Reactome Protein details: O95139
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
NDUFB6 for ontologies About GeneDecksing
NDUFB6 Antibody Products:
Assay Products for NDUFB6: |
Protein
Domains /
Families
for NDUFB6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NDUFB6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95139ProtoNet protein and cluster: O95139 UniProtKB/Swiss-Prot: NDUB6_HUMAN, O95139Similarity: Belongs to the complex I NDUFB6 subunit family |
Function
for NDUFB6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NDUB6_HUMAN, O95139Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone Genatlas biochemistry entry for NDUFB6:NADH ubiquinone oxidoreductase (Q reductase),17kDa,component beta 6,hydrophobic fraction of the complex I multi-subunitenzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB6 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
NAS | 9878551 |
NDUFB6 for ontologies About GeneDecksing
|
Pathways & Interactions
for NDUFB6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NDUFB6
4 
Reactome Pathways for NDUFB6
5 
Kegg Pathways (Kegg details for NDUFB6):
NDUFB6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NDUFB6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/59 Interacting proteins for NDUFB6 (O951392, 3 ENSP000003691764) via UniProtKB, MINT, STRING, and/or I2D (see all 59)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
NAS | 9878551 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
NDUFB6 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDUFB6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NDUFB6
8 HMDB Compounds for NDUFB6 About this table
1 DrugBank Compound for NDUFB6 About this table
Search CenterWatch for drugs/clinical trials and news about NDUFB6 / NDUB6
|
Transcripts
for NDUFB6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NDUFB6 gene (3 alternative transcripts): NM_001199987.1 NM_002493.4 NM_182739.2 Unigene Cluster for NDUFB6: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa Hs.493668 [show with all ESTs]Unigene Representative Sequence: BG5384892 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379847(uc003zre.2 uc003zrf.2 uc022bfg.1) ENST00000350021
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFB6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): NDUFB6 (NM_001199987) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDUFB6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB6 |
Additional cDNA sequence: AF035840.1 AF067167.1 AK289702.1 BC009801.1 BC016708.1 BC029247.1 CR456920.1 15 DOTS entries: DT.92432650 DT.117406 DT.121195859 DT.100815325 DT.100665071 DT.91638995 DT.95276696 DT.121195801 DT.121195849 DT.91729399 DT.92432643 DT.120978785 DT.95276695 DT.95325964 DT.97764369 24/211 AceView cDNA sequences (see all 211): AA335362 CK430054 C16589 AW663650 BM313417 CB109688 AI302218 AI874275 AW160372 BU952486 AI199937 AA316378 CD678287 CR456920 AI344520 NM_002493 AA953275 BC029247 BX111809 AA771787 AA074188 AA371853 CB155752 AI128306
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB6 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NDUFB6
|
Expression
for NDUFB6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDUFB6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NDUFB6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDUFB6
SOURCE GeneReport for Unigene cluster: Hs.493668
SABiosciences Expression via Pathway-Focused PCR Arrays including NDUFB6:
Primer
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB6 |
Orthologs
for NDUFB6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NDUFB6 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for NDUFB6 (if available)
TreeFam Gene Tree for NDUFB6 (if available) |
Paralogs
for NDUFB6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NDUFB6 gene
NDUFB6 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NDUFB6
PGOHUM00000240124
|
Genomic Variants
for NDUFB6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NDUFB6 (32552997 - 32573182 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NDUFB6
2 CNVs: 95932 95931
Human Gene Mutation Database (HGMD): NDUFB6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFB6 |
|
Disorders
/ Diseases
for NDUFB6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDUFB6 for disorders About GeneDecksing
OMIM gene information: 603322
OMIM disorders: --
6  diseases for NDUFB6: About MalaCardsmitochondrial complex i deficiency intrahepatic cholangiocarcinoma huntington's disease cholangiocarcinoma
parkinson's disease prostatitis
Human Genome Epidemiology (HuGE) Navigator: NDUFB6 (3 documents)
Export disorders for NDUFB6 gene to outside databases
|
Publications
for NDUFB6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NDUFB6 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with NDUFB6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization and mutational analysis of the human B17 subunit of the mitochondrial respiratory chain complex I. (PubMed id 9760212)1, 2, 3 Smeitink J.... van den Heuvel L. (1998)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
|
External Searches for NDUFB6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDUFB6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFB6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFB6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NDUFB6 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NDUFB6 gene:
Search GeneIP for patents involving NDUFB6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDUFB6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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