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Aliases for NDUFB5 Gene

Aliases for NDUFB5 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B5 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5, 16kDa 2 3
  • NADH-Ubiquinone Oxidoreductase SGDH Subunit 3 4
  • Complex I SGDH Subunit 2 3
  • Complex I-SGDH 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5 (16kD, SGDH) 2
  • CI-SGDH 4
  • CISGDH 3
  • SGDH 3

External Ids for NDUFB5 Gene

Previous GeneCards Identifiers for NDUFB5 Gene

  • GC03P176087
  • GC03P180165
  • GC03P180724
  • GC03P180643
  • GC03P180805
  • GC03P179322
  • GC03P176726

Summaries for NDUFB5 Gene

Entrez Gene Summary for NDUFB5 Gene

  • The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NDUFB5 Gene

NDUFB5 (NADH:Ubiquinone Oxidoreductase Subunit B5) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB5 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB5 Gene

Genomics for NDUFB5 Gene

Regulatory Elements for NDUFB5 Gene

Promoters for NDUFB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDUFB5 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDUFB5 Gene

Chromosome:
3
Start:
179,604,690 bp from pter
End:
179,627,647 bp from pter
Size:
22,958 bases
Orientation:
Plus strand

Genomic View for NDUFB5 Gene

Genes around NDUFB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB5 Gene

Proteins for NDUFB5 Gene

  • Protein details for NDUFB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43674-NDUB5_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
    Protein Accession:
    O43674
    Secondary Accessions:
    • Q561V6

    Protein attributes for NDUFB5 Gene

    Size:
    189 amino acids
    Molecular mass:
    21750 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB5 Gene

Proteomics data for NDUFB5 Gene at MOPED

Post-translational modifications for NDUFB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for NDUFB5 Gene

Domains & Families for NDUFB5 Gene

Protein Domains for NDUFB5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43674

UniProtKB/Swiss-Prot:

NDUB5_HUMAN :
  • Belongs to the complex I NDUFB5 subunit family.
Family:
  • Belongs to the complex I NDUFB5 subunit family.
genes like me logo Genes that share domains with NDUFB5: view

Function for NDUFB5 Gene

Molecular function for NDUFB5 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
genes like me logo Genes that share phenotypes with NDUFB5: view

Animal Model Products

miRNA for NDUFB5 Gene

miRTarBase miRNAs that target NDUFB5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB5 Gene

Localization for NDUFB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB5 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB5 Gene COMPARTMENTS Subcellular localization image for NDUFB5 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with NDUFB5: view

Pathways & Interactions for NDUFB5 Gene

genes like me logo Genes that share pathways with NDUFB5: view

Interacting Proteins for NDUFB5 Gene

Gene Ontology (GO) - Biological Process for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
genes like me logo Genes that share ontologies with NDUFB5: view

No data available for SIGNOR curated interactions for NDUFB5 Gene

Drugs & Compounds for NDUFB5 Gene

(5) Drugs for NDUFB5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFB5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFB5: view

Transcripts for NDUFB5 Gene

Unigene Clusters for NDUFB5 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - -
SP10:
SP11: - -

Relevant External Links for NDUFB5 Gene

GeneLoc Exon Structure for
NDUFB5
ECgene alternative splicing isoforms for
NDUFB5

Expression for NDUFB5 Gene

mRNA expression in normal human tissues for NDUFB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFB5 Gene

This gene is overexpressed in Nasal epithelium (16.0), Heart (8.2), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB5 Gene



SOURCE GeneReport for Unigene cluster for NDUFB5 Gene Hs.730674

genes like me logo Genes that share expression patterns with NDUFB5: view

Protein tissue co-expression partners for NDUFB5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFB5 Gene

Orthologs for NDUFB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB5 36
  • 100 (a)
OneToOne
NDUFB5 35
  • 99.29 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia NDUFB5 35
  • 85.89 (n)
  • 85.19 (a)
NDUFB5 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB5 36
  • 79 (a)
OneToOne
NDUFB5 35
  • 85.36 (n)
  • 82.01 (a)
mouse
(Mus musculus)
Mammalia Ndufb5 16
Ndufb5 36
  • 76 (a)
OneToOne
Ndufb5 35
  • 78.84 (n)
  • 75.66 (a)
oppossum
(Monodelphis domestica)
Mammalia NDUFB5 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB5 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb5 35
  • 78.31 (n)
  • 76.19 (a)
chicken
(Gallus gallus)
Aves NDUFB5 35
  • 67.03 (n)
  • 64.86 (a)
NDUFB5 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB5 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ndufb5-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb5 35
  • 65.76 (n)
  • 65.57 (a)
Str.1944 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8572 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ndufb5 35
  • 59.24 (n)
  • 58.7 (a)
ndufb5 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007297 35
  • 47.73 (n)
  • 45.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo18 35
  • 49.87 (n)
  • 49.61 (a)
l(3)neo18 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3719 36
  • 26 (a)
OneToOne
Species with no ortholog for NDUFB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB5 Gene

ENSEMBL:
Gene Tree for NDUFB5 (if available)
TreeFam:
Gene Tree for NDUFB5 (if available)

Paralogs for NDUFB5 Gene

Pseudogenes.org Pseudogenes for NDUFB5 Gene

genes like me logo Genes that share paralogs with NDUFB5: view

No data available for Paralogs for NDUFB5 Gene

Variants for NDUFB5 Gene

Sequence variations from dbSNP and Humsavar for NDUFB5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs4147793 - 179,618,469(+) AGATA(C/T)ATGAA intron-variant, reference, missense
rs1046075 -- 179,624,263(+) TGAAC(C/T)CCTAA utr-variant-3-prime
rs2339845 -- 179,624,820(+) ttgac(A/G)aaatc downstream-variant-500B
rs2339846 -- 179,624,859(+) TGCCG(C/T)GATCT downstream-variant-500B
rs4147787 -- 179,611,227(+) CTAGG(C/T)CAGTA intron-variant

Variation tolerance for NDUFB5 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFB5 Gene

HapMap Linkage Disequilibrium report
NDUFB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFB5 Gene

Disorders for NDUFB5 Gene

Relevant External Links for NDUFB5

Genetic Association Database (GAD)
NDUFB5
Human Genome Epidemiology (HuGE) Navigator
NDUFB5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFB5

No disorders were found for NDUFB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFB5 Gene

Publications for NDUFB5 Gene

  1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C. … Liew C.-C. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for NDUFB5 Gene

Sources for NDUFB5 Gene

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