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Aliases for NDUFB5 Gene

Aliases for NDUFB5 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B5 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5, 16kDa 2 3
  • NADH-Ubiquinone Oxidoreductase SGDH Subunit 3 4
  • Complex I SGDH Subunit 2 3
  • Complex I-SGDH 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5 (16kD, SGDH) 2
  • CI-SGDH 4
  • CISGDH 3
  • SGDH 3

External Ids for NDUFB5 Gene

Previous GeneCards Identifiers for NDUFB5 Gene

  • GC03P176087
  • GC03P180165
  • GC03P180724
  • GC03P180643
  • GC03P180805
  • GC03P179322
  • GC03P176726

Summaries for NDUFB5 Gene

Entrez Gene Summary for NDUFB5 Gene

  • The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NDUFB5 Gene

NDUFB5 (NADH:Ubiquinone Oxidoreductase Subunit B5) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB5 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB5 Gene

Genomics for NDUFB5 Gene

Regulatory Elements for NDUFB5 Gene

Enhancers for NDUFB5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F179603 1.1 ENCODE 9.6 -0.1 -94 2.4 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LRRFIP1P1 ZNF639 TTC14 USP13 NDUFB5 MRPL47 ENSG00000272660
GH03F179612 0.9 ENCODE 9.7 +9.8 9774 3.2 HDAC1 CBX3 ATF1 ARNT TBL1XR1 SIN3A CHAMP1 ZNF121 GATA2 CREM USP13 NDUFB5 ENSG00000239096
GH03F179608 0.8 Ensembl ENCODE 6.5 +4.4 4412 1.2 ZNF664 ZNF121 POLR2H MTA2 ZBTB33 KDM1A SPI1 USP13 MRPL47 NDUFB5 ENSG00000239096
GH03F179525 1 Ensembl ENCODE 4.8 -77.8 -77764 2.3 ETV1 ZIC2 RAD21 ETS1 POLR2A ZNF652 MAZ L3MBTL2 HLF CEBPB ENSG00000239255 GNB4 NDUFB5 PIR62273 ACTL6A
GH03F179626 0.4 ENCODE 8.7 +22.6 22594 1.1 ZBTB33 USP13 NDUFB5 MRPL47 GC03P179625 GC03P179640
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NDUFB5 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFB5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001380609 110 2401 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for NDUFB5 Gene

Chromosome:
3
Start:
179,604,690 bp from pter
End:
179,627,647 bp from pter
Size:
22,958 bases
Orientation:
Plus strand

Genomic View for NDUFB5 Gene

Genes around NDUFB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB5 Gene

Proteins for NDUFB5 Gene

  • Protein details for NDUFB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43674-NDUB5_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
    Protein Accession:
    O43674
    Secondary Accessions:
    • Q561V6

    Protein attributes for NDUFB5 Gene

    Size:
    189 amino acids
    Molecular mass:
    21750 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB5 Gene

Post-translational modifications for NDUFB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDUFB5 Gene

Domains & Families for NDUFB5 Gene

Protein Domains for NDUFB5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43674

UniProtKB/Swiss-Prot:

NDUB5_HUMAN :
  • Belongs to the complex I NDUFB5 subunit family.
Family:
  • Belongs to the complex I NDUFB5 subunit family.
genes like me logo Genes that share domains with NDUFB5: view

Function for NDUFB5 Gene

Molecular function for NDUFB5 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS,TAS 9878551
genes like me logo Genes that share ontologies with NDUFB5: view
genes like me logo Genes that share phenotypes with NDUFB5: view

Animal Model Products

miRNA for NDUFB5 Gene

miRTarBase miRNAs that target NDUFB5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB5 Gene

Localization for NDUFB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB5 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFB5 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDUFB5: view

Pathways & Interactions for NDUFB5 Gene

genes like me logo Genes that share pathways with NDUFB5: view

Gene Ontology (GO) - Biological Process for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB5: view

No data available for SIGNOR curated interactions for NDUFB5 Gene

Drugs & Compounds for NDUFB5 Gene

(5) Drugs for NDUFB5 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFB5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFB5: view

Transcripts for NDUFB5 Gene

Unigene Clusters for NDUFB5 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - -
SP10:
SP11: - -

Relevant External Links for NDUFB5 Gene

GeneLoc Exon Structure for
NDUFB5
ECgene alternative splicing isoforms for
NDUFB5

Expression for NDUFB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NDUFB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFB5 Gene

This gene is overexpressed in Nasal epithelium (16.0), Heart (8.2), and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFB5 Gene



Protein tissue co-expression partners for NDUFB5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFB5 Gene:

NDUFB5

SOURCE GeneReport for Unigene cluster for NDUFB5 Gene:

Hs.730674
genes like me logo Genes that share expression patterns with NDUFB5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFB5 Gene

Orthologs for NDUFB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB5 34 35
  • 99.29 (n)
cow
(Bos Taurus)
Mammalia NDUFB5 34 35
  • 85.89 (n)
dog
(Canis familiaris)
Mammalia NDUFB5 34 35
  • 85.36 (n)
mouse
(Mus musculus)
Mammalia Ndufb5 34 16 35
  • 78.84 (n)
rat
(Rattus norvegicus)
Mammalia Ndufb5 34
  • 78.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB5 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB5 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFB5 34 35
  • 67.03 (n)
lizard
(Anolis carolinensis)
Reptilia NDUFB5 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb5 34
  • 65.76 (n)
Str.1944 34
African clawed frog
(Xenopus laevis)
Amphibia ndufb5-prov 34
zebrafish
(Danio rerio)
Actinopterygii ndufb5 34 35
  • 59.24 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8572 34
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo18 34 35
  • 49.87 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007297 34
  • 47.73 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3719 35
  • 26 (a)
OneToOne
Species where no ortholog for NDUFB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB5 Gene

ENSEMBL:
Gene Tree for NDUFB5 (if available)
TreeFam:
Gene Tree for NDUFB5 (if available)

Paralogs for NDUFB5 Gene

Pseudogenes.org Pseudogenes for NDUFB5 Gene

genes like me logo Genes that share paralogs with NDUFB5: view

No data available for Paralogs for NDUFB5 Gene

Variants for NDUFB5 Gene

Sequence variations from dbSNP and Humsavar for NDUFB5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1046075 -- 179,624,263(+) TGAAC(C/T)CCTAA utr-variant-3-prime
rs111435894 -- 179,616,548(+) CCCCC(A/C)AAAAA intron-variant
rs111497349 -- 179,619,258(+) TGCAG(G/T)TTAGT intron-variant
rs111759352 -- 179,610,886(+) GATGT(A/G)TAAAC intron-variant
rs111795320 -- 179,619,047(+) CCAGT(G/T)AAATA intron-variant

Variation tolerance for NDUFB5 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFB5 Gene

Disorders for NDUFB5 Gene

Relevant External Links for NDUFB5

Genetic Association Database (GAD)
NDUFB5
Human Genome Epidemiology (HuGE) Navigator
NDUFB5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFB5

No disorders were found for NDUFB5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFB5 Gene

Publications for NDUFB5 Gene

  1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C. … Liew C.-C. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 46 64
  5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64

Products for NDUFB5 Gene

Sources for NDUFB5 Gene

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