Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NDUFB5 Gene

Aliases for NDUFB5 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5, 16kDa 2 3
  • NADH-Ubiquinone Oxidoreductase SGDH Subunit 3 4
  • Complex I SGDH Subunit 2 3
  • Complex I-SGDH 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5 (16kD, SGDH) 2
  • CI-SGDH 4
  • CISGDH 3
  • SGDH 3

External Ids for NDUFB5 Gene

Previous GeneCards Identifiers for NDUFB5 Gene

  • GC03P176087
  • GC03P180165
  • GC03P180724
  • GC03P180643
  • GC03P180805
  • GC03P179322
  • GC03P176726

Summaries for NDUFB5 Gene

Entrez Gene Summary for NDUFB5 Gene

  • The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NDUFB5 Gene

NDUFB5 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5, 16kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB5 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB5 Gene

Genomics for NDUFB5 Gene

Regulatory Elements for NDUFB5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDUFB5 Gene

Start:
179,604,690 bp from pter
End:
179,627,647 bp from pter
Size:
22,958 bases
Orientation:
Plus strand

Genomic View for NDUFB5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB5 Gene

Proteins for NDUFB5 Gene

  • Protein details for NDUFB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43674-NDUB5_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
    Protein Accession:
    O43674
    Secondary Accessions:
    • Q561V6

    Protein attributes for NDUFB5 Gene

    Size:
    189 amino acids
    Molecular mass:
    21750 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB5 Gene

Proteomics data for NDUFB5 Gene at MOPED

Post-translational modifications for NDUFB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDUFB5 Gene

Domains for NDUFB5 Gene

Gene Families for NDUFB5 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB5 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43674

UniProtKB/Swiss-Prot:

NDUB5_HUMAN :
  • O43674
Family:
  • Belongs to the complex I NDUFB5 subunit family.
genes like me logo Genes that share domains with NDUFB5: view

Function for NDUFB5 Gene

Molecular function for NDUFB5 Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB5: view

Phenotypes for NDUFB5 Gene

GenomeRNAi human phenotypes for NDUFB5:
genes like me logo Genes that share phenotypes with NDUFB5: view

Animal Model Products

CRISPR Products

miRNA for NDUFB5 Gene

miRTarBase miRNAs that target NDUFB5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFB5 Gene

Localization for NDUFB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB5 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB5 Gene COMPARTMENTS Subcellular localization image for NDUFB5 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
genes like me logo Genes that share ontologies with NDUFB5: view

Pathways for NDUFB5 Gene

genes like me logo Genes that share pathways with NDUFB5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NDUFB5 Gene

Gene Ontology (GO) - Biological Process for NDUFB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB5: view

Compounds for NDUFB5 Gene

(8) HMDB Compounds for NDUFB5 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB5: view

Transcripts for NDUFB5 Gene

Unigene Clusters for NDUFB5 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB5 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - -
SP9: - - - - - -
SP10:
SP11: - -

Relevant External Links for NDUFB5 Gene

GeneLoc Exon Structure for
NDUFB5
ECgene alternative splicing isoforms for
NDUFB5

Expression for NDUFB5 Gene

mRNA expression in normal human tissues for NDUFB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB5 Gene

SOURCE GeneReport for Unigene cluster for NDUFB5 Gene Hs.730674

genes like me logo Genes that share expressions with NDUFB5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFB5 Gene

Orthologs for NDUFB5 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB5 35
  • 99.29 (n)
  • 100 (a)
NDUFB5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB5 35
  • 85.89 (n)
  • 85.19 (a)
NDUFB5 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB5 35
  • 85.36 (n)
  • 82.01 (a)
NDUFB5 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufb5 35
  • 78.84 (n)
  • 75.66 (a)
Ndufb5 16
Ndufb5 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB5 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB5 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb5 35
  • 78.31 (n)
  • 76.19 (a)
chicken
(Gallus gallus)
Aves NDUFB5 35
  • 67.03 (n)
  • 64.86 (a)
NDUFB5 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB5 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ndufb5-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb5 35
  • 65.76 (n)
  • 65.57 (a)
Str.1944 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8572 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ndufb5 35
  • 59.24 (n)
  • 58.7 (a)
ndufb5 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007297 35
  • 47.73 (n)
  • 45.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(3)neo18 35
  • 49.87 (n)
  • 49.61 (a)
l(3)neo18 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3719 36
  • 26 (a)
OneToOne
Species with no ortholog for NDUFB5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB5 Gene

ENSEMBL:
Gene Tree for NDUFB5 (if available)
TreeFam:
Gene Tree for NDUFB5 (if available)

Paralogs for NDUFB5 Gene

Pseudogenes.org Pseudogenes for NDUFB5 Gene

genes like me logo Genes that share paralogs with NDUFB5: view

No data available for Paralogs for NDUFB5 Gene

Variants for NDUFB5 Gene

Sequence variations from dbSNP and Humsavar for NDUFB5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1046075 -- 179,624,263(+) TGAAC(C/T)CCTAA utr-variant-3-prime
rs1802238 -- 179,615,053(+) TTGAA(G/T)TTATT intron-variant, reference, missense
rs2339845 -- 179,624,820(+) ttgac(A/G)aaatc downstream-variant-500B
rs2339846 -- 179,624,859(+) TGCCG(C/T)GATCT downstream-variant-500B
rs3832244 -- 179,624,604(+) CACAC(-/ACACACACAC/ACACACACACAC/ACACACACACACAC)GCTCT downstream-variant-500B

Relevant External Links for NDUFB5 Gene

HapMap Linkage Disequilibrium report
NDUFB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFB5 Gene

Disorders for NDUFB5 Gene

Relevant External Links for NDUFB5

Genetic Association Database (GAD)
NDUFB5
Human Genome Epidemiology (HuGE) Navigator
NDUFB5
genes like me logo Genes that share disorders with NDUFB5: view

No data available for UniProtKB/Swiss-Prot for NDUFB5 Gene

Publications for NDUFB5 Gene

  1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C. … Liew C.-C. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  2. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 48
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 48

Products for NDUFB5 Gene

Sources for NDUFB5 Gene

Back to Top

Content