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NDUFB5 Gene

protein-coding   GIFtS: 55
GCID: GC03P179322

NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5, 16kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 (16kD,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5, 16kDa1 2     CISGDH2
Complex I SGDH Subunit1 2     SGDH2
Complex I-SGDH2 3     NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial2
NADH-Ubiquinone Oxidoreductase SGDH Subunit2 3     CI-SGDH3
NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 5 (16kD, SGDH)1     

External Ids:    HGNC: 77001   Entrez Gene: 47112   Ensembl: ENSG000001365217   OMIM: 6038415   UniProtKB: O436743   
ORGUL members:         

Export aliases for NDUFB5 gene to outside databases

Previous GC identifers: GC03P176087 GC03P180165 GC03P180724 GC03P180643 GC03P180805 GC03P176726


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDUFB5 Gene:
The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I).
Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This
protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for NDUFB5 Gene:
NDUFB5 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa) is a protein-coding gene. Diseases associated with NDUFB5 include fatty liver disease, and huntington's disease. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NDUB5_HUMAN, O43674
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFB5 gene promoter:
         HOXA9B   HOXA9   Nkx2-2   MIF-1   Meis-1b   Evi-1   HFH-1   COMP1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFB5 promoter sequence
   Search Chromatin IP Primers for NDUFB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.33   Ensembl cytogenetic band:  3q26.33   HGNC cytogenetic band: 3q27.1

NDUFB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFB5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P179322:  view genomic region     (about GC identifiers)

Start:
179,322,478 bp from pter      End:
179,345,435 bp from pter
Size:
22,958 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDUB5_HUMAN, O43674 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial precursor  
Size: 189 amino acids; 21750 Da
Subunit: Complex I is composed of 45 different subunits
Secondary accessions: Q561V6
Alternative splicing: 2 isoforms:  O43674-1   O43674-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDUFB5: NX_O43674

Explore proteomics data for NDUFB5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NDUFB5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001186886.1  NP_001186887.1  NP_002483.1  

    ENSEMBL proteins: 
     ENSP00000259037   ENSP00000419656   ENSP00000419248   ENSP00000420538   ENSP00000353026  
     ENSP00000418354   ENSP00000419099   ENSP00000419501  
    Reactome Protein details: O43674

    NDUFB5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    1 InterPro protein domain:
     IPR019173 NADH_UbQ_OxRdtase_B5_su

    Graphical View of Domain Structure for InterPro Entry O43674

    ProtoNet protein and cluster: O43674

    UniProtKB/Swiss-Prot: NDUB5_HUMAN, O43674
    Similarity: Belongs to the complex I NDUFB5 subunit family


    NDUFB5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUB5_HUMAN, O43674
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    NDUFB5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NDUFB5:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFB5
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    miRTarBase miRNAs that target NDUFB5:
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    Block miRNA regulation of human, mouse, rat NDUFB5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate NDUFB5:
    hsa-miR-548p hsa-miR-1276 hsa-miR-4311 hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidNDUFB5 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDUB5_HUMAN, O43674: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551

    NDUFB5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDUFB5 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFB5
        Oxidative phosphorylation
    Electron Transport Chain


    1 Reactome Pathway for NDUFB5
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for NDUFB5) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFB5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFB5: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFB5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFB5 (O436743 ENSP000002590374) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    DGCR14Q96DF83I2D: score=4 
    PAHP004393I2D: score=4 
    NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
    CYC1ENSP000003171594STRING: ENSP00000317159
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFB5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFB5 (NDUB5)

    8 HMDB Compounds for NDUFB5    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFB5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NDUFB5 gene (3 alternative transcripts): 
    NM_001199957.1  NM_001199958.1  NM_002492.3  

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488002 ENST00000259037(uc003fkc.3 uc021xhu.1 uc003fke.3 uc003fkd.3)
    ENST00000493866 ENST00000472629 ENST00000468210 ENST00000359944 ENST00000477177
    ENST00000482604 ENST00000480374 ENST00000496904 ENST00000473500 ENST00000491054
    ENST00000471112 ENST00000476587 ENST00000493716
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    4 qRT-PCR Assays for microRNAs that regulate NDUFB5:
    hsa-miR-548p hsa-miR-1276 hsa-miR-4311 hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidNDUFB5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NDUFB5
      QuantiFast Probe-based Assays in human, mouse, rat NDUFB5

    Selected AceView cDNA sequences (see all 690):

    BU952251 NM_002492 BU622210 CD676268 AI277045 BM980609 CA311644 CA420375 
    AI139727 W15509 AA300598 BQ049545 BM055418 AI087788 BE739186 AA262461 
    AA846565 CD364869 BF593729 AI734848 BX103521 BI771280 BM264035 AW296501 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB5 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g · 8h
    SP1:                                                  -     -           -                 -                                                         
    SP2:                                                        -     -     -                 -                                                         
    SP3:                                                  -     -     -     -                 -                                                         
    SP4:                                                  -     -     -     -                 -                                                         
    SP5:                                                  -     -           -                 -     -                                                   


    ECgene alternative splicing isoforms for NDUFB5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDUFB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGAGGAGA
    NDUFB5 Expression
    About this image


    NDUFB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Thyroid (Endocrine System)
     
     Ovary (Reproductive System)
    NDUFB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFB5 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFB5: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDUFB5 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufb51 , 5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more1, 5 78.84(n)1
    75.66(a)1
      3 (15.85 cM)5
    660461  NM_025316.21  NP_079592.21 
     327369905 
    chicken
    (Gallus gallus)
    Aves NDUFB51 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 67.03(n)
    64.86(a)
      424978  NM_001006553.1  NP_001006553.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFB56
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex,...
    62(a)
    1 ↔ 1
    3(2093917-2101191)
    African clawed frog
    (Xenopus laevis)
    Amphibia ndufb5-prov2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 77.63(n)    BC041310.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CB364996.12   -- 74.85(n)   321340  CB364996.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(3)neo181 lethal (3) neo18 49.87(n)
    49.61(a)
      46260  NM_001274813.1  NP_001261742.1 


    ENSEMBL Gene Tree for NDUFB5 (if available)
    TreeFam Gene Tree for NDUFB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDUFB5 gene

    NDUFB5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NDUFB5
    PGOHUM00000245778 PGOHUM00000241456


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDUFB5 (see all 385)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445720121,2
    C--179324509(+) TGTGCA/GATAGA 3 -- int10--------
    rs1484554491,2
    C--179324601(+) TTCTCC/GCAGTT 3 -- int10--------
    rs1425468611,2
    --179324631(+) CCACAG/TGATGA 3 -- int10--------
    rs1871487191,2
    --179324666(+) GAAACA/CTGATG 3 -- int10--------
    rs1891041291,2
    --179324830(+) ATTCAA/GTCAAA 3 -- int10--------
    rs738835711,2
    C--179324869(+) TTCACC/TCCCAG 3 -- int14Minor allele frequency- T:0.07WA NA EA 360
    rs1459767501,2
    --179325000(+) TTTTCA/CGCTGT 3 -- int10--------
    rs1814443041,2
    --179325111(+) TAATGC/TAGTAG 3 -- int10--------
    rs1857840381,2
    --179325148(+) GGAGAC/TAGACT 3 -- int10--------
    rs1176474331,2
    F--179325220(+) AAGCTA/CAAGTG 3 -- int11Minor allele frequency- C:0.03EA 120

    HapMap Linkage Disequilibrium report for NDUFB5 (179322478 - 179345435 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NDUFB5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFB5
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFB5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603841    OMIM disorders: --

    9 diseases for NDUFB5:    
    About MalaCards
    fatty liver disease    huntington's disease    parkinson's disease    schizophrenia
    liver disease    alzheimer's disease    malaria    prostate cancer
    prostatitis


    NDUFB5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NDUFB5
    Human Genome Epidemiology (HuGE) Navigator: NDUFB5 (5 documents)

    Export disorders for NDUFB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDUFB5 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with NDUFB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PubMed id 9425316)1, 2, 3 Ton C.... Liew C.-C. (Biochem. Biophys. Res. Commun. 1997)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4711 HGNC: 7700 AceView: NDUFB5 Ensembl:ENSG00000136521 euGenes: HUgn4711
    ECgene: NDUFB5 Kegg: 4711 H-InvDB: NDUFB5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDUFB5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDUFB5 gene:
    Search GeneIP for patents involving NDUFB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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