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Aliases for NDUFB4 Gene

Aliases for NDUFB4 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B4 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 4, 15kDa 2 3
  • NADH-Ubiquinone Oxidoreductase B15 Subunit 3 4
  • Complex I B15 Subunit 2 3
  • Complex I-B15 3 4
  • CI-B15 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 4 (15kD, B15) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 4 3
  • B15 3

External Ids for NDUFB4 Gene

Previous GeneCards Identifiers for NDUFB4 Gene

  • GC03P116949
  • GC03P119956
  • GC03P121596
  • GC03P121636
  • GC03P121797
  • GC03P120315
  • GC03P117688

Summaries for NDUFB4 Gene

Entrez Gene Summary for NDUFB4 Gene

  • This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]

GeneCards Summary for NDUFB4 Gene

NDUFB4 (NADH:Ubiquinone Oxidoreductase Subunit B4) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB4 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB4 Gene

Genomics for NDUFB4 Gene

Regulatory Elements for NDUFB4 Gene

Enhancers for NDUFB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NDUFB4 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for NDUFB4 Gene

Chromosome:
3
Start:
120,596,281 bp from pter
End:
120,602,500 bp from pter
Size:
6,220 bases
Orientation:
Plus strand

Genomic View for NDUFB4 Gene

Genes around NDUFB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB4 Gene

Proteins for NDUFB4 Gene

  • Protein details for NDUFB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95168-NDUB4_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
    Protein Accession:
    O95168
    Secondary Accessions:
    • B2RUY3
    • B9EJC7

    Protein attributes for NDUFB4 Gene

    Size:
    129 amino acids
    Molecular mass:
    15209 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB4 Gene

Post-translational modifications for NDUFB4 Gene

  • Ubiquitination at Lys 5
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFB4 Gene

No data available for DME Specific Peptides for NDUFB4 Gene

Domains & Families for NDUFB4 Gene

Protein Domains for NDUFB4 Gene

Suggested Antigen Peptide Sequences for NDUFB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95168

UniProtKB/Swiss-Prot:

NDUB4_HUMAN :
  • Belongs to the complex I NDUFB4 subunit family.
Family:
  • Belongs to the complex I NDUFB4 subunit family.
genes like me logo Genes that share domains with NDUFB4: view

Function for NDUFB4 Gene

Molecular function for NDUFB4 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB4: view
genes like me logo Genes that share phenotypes with NDUFB4: view

Animal Model Products

CRISPR Products

miRNA for NDUFB4 Gene

miRTarBase miRNAs that target NDUFB4

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB4 Gene

Localization for NDUFB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB4 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB4 Gene COMPARTMENTS Subcellular localization image for NDUFB4 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NDUFB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDUFB4: view

Pathways & Interactions for NDUFB4 Gene

genes like me logo Genes that share pathways with NDUFB4: view

Gene Ontology (GO) - Biological Process for NDUFB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone TAS --
GO:0006979 response to oxidative stress IDA 12857734
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
genes like me logo Genes that share ontologies with NDUFB4: view

No data available for SIGNOR curated interactions for NDUFB4 Gene

Drugs & Compounds for NDUFB4 Gene

(5) Drugs for NDUFB4 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFB4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFB4: view

Transcripts for NDUFB4 Gene

Unigene Clusters for NDUFB4 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB4 Gene

No ASD Table

Relevant External Links for NDUFB4 Gene

GeneLoc Exon Structure for
NDUFB4
ECgene alternative splicing isoforms for
NDUFB4

Expression for NDUFB4 Gene

mRNA expression in normal human tissues for NDUFB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFB4 Gene

This gene is overexpressed in Heart (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFB4 Gene



Protein tissue co-expression partners for NDUFB4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFB4 Gene:

NDUFB4

SOURCE GeneReport for Unigene cluster for NDUFB4 Gene:

Hs.304613
genes like me logo Genes that share expression patterns with NDUFB4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFB4 Gene

Orthologs for NDUFB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFB4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFB4 34
  • 82.69 (n)
  • 73.64 (a)
-- 35
  • 71 (a)
OneToMany
NDUFB4 35
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NDUFB4 34
  • 84.11 (n)
  • 78.91 (a)
NDUFB4 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm3244 34
  • 78.29 (n)
  • 75.19 (a)
Ndufb4 16
Ndufb4 35
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDUFB4 34
  • 100 (n)
  • 100 (a)
NDUFB4 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb4 34
  • 78.29 (n)
  • 73.64 (a)
oppossum
(Monodelphis domestica)
Mammalia NDUFB4 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFB4 34
  • 64.33 (n)
  • 61.4 (a)
NDUFB4 35
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB4 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb4 34
  • 60.8 (n)
  • 63.2 (a)
zebrafish
(Danio rerio)
Actinopterygii ndufb4 34
  • 59.62 (n)
  • 54.47 (a)
Species where no ortholog for NDUFB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB4 Gene

ENSEMBL:
Gene Tree for NDUFB4 (if available)
TreeFam:
Gene Tree for NDUFB4 (if available)

Paralogs for NDUFB4 Gene

genes like me logo Genes that share paralogs with NDUFB4: view

No data available for Paralogs for NDUFB4 Gene

Variants for NDUFB4 Gene

Sequence variations from dbSNP and Humsavar for NDUFB4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs12762 -- 120,602,092(+) TTGTA(C/T)GGTGG intron-variant, utr-variant-3-prime
rs701991 -- 120,600,091(+) AACGG(A/G)AGCAT intron-variant
rs1583654 -- 120,598,622(+) CTACA(A/G)TCTTA intron-variant
rs12635956 -- 120,597,005(+) ATTCT(A/C)TATAT intron-variant
rs35085316 -- 120,599,426(+) CCAGC(A/G)AGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB4 Gene

Variant ID Type Subtype PubMed ID
esv3307731 CNV mobile element insertion 20981092
esv3339199 CNV insertion 20981092
esv3345242 CNV insertion 20981092
esv3362822 CNV insertion 20981092
nsv508238 CNV deletion 20534489
nsv829699 CNV loss 17160897

Variation tolerance for NDUFB4 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB4 Gene

Disorders for NDUFB4 Gene

Relevant External Links for NDUFB4

Genetic Association Database (GAD)
NDUFB4
Human Genome Epidemiology (HuGE) Navigator
NDUFB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFB4

No disorders were found for NDUFB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFB4 Gene

Publications for NDUFB4 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 65
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4 65
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 65

Products for NDUFB4 Gene

Sources for NDUFB4 Gene

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