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NDUFB4 Gene

protein-coding   GIFtS: 56
GCID: GC03P120315

NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 4, 15kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4 (15kD,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 4, 15kDa1 2     NADH-Ubiquinone Oxidoreductase B15 Subunit2 3
Complex I B15 Subunit1 2     NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 4 (15kD, B15)1
Complex I-B152 3     B152
CI-B152 3     NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 42

External Ids:    HGNC: 76991   Entrez Gene: 47102   Ensembl: ENSG000000655187   OMIM: 6038405   UniProtKB: O951683   

Export aliases for NDUFB4 gene to outside databases

Previous GC identifers: GC03P116949 GC03P119956 GC03P121596 GC03P121636 GC03P121797 GC03P117688


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDUFB4 Gene:
This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme
complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45
different subunits and transfers electrons from NADH to ubiquinone. (provided by RefSeq, Dec 2009)

GeneCards Summary for NDUFB4 Gene:
NDUFB4 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa) is a protein-coding gene. Diseases associated with NDUFB4 include mumps, and rubella. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NDUB4_HUMAN, O95168
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFB4 gene promoter:
         HOXA9B   HOXA9   POU2F1   POU2F1a   FOXO3a   FOXO3   POU3F2 (N-Oct-5b)   Meis-1b   Meis-1   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFB4 promoter sequence
   Search Chromatin IP Primers for NDUFB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.33   Ensembl cytogenetic band:  3q13.33   HGNC cytogenetic band: 3q13.33

NDUFB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFB4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P120315:  view genomic region     (about GC identifiers)

Start:
120,315,128 bp from pter      End:
120,321,347 bp from pter
Size:
6,220 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDUB4_HUMAN, O95168 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4  
Size: 129 amino acids; 15209 Da
Subunit: Complex I is composed of 45 different subunits
Secondary accessions: B2RUY3 B9EJC7
Alternative splicing: 2 isoforms:  O95168-1   O95168-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDUFB4: NX_O95168

Explore proteomics data for NDUFB4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys5
  • Modification sites at PhosphoSitePlus

  • See NDUFB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161803.1  NP_004538.2  

    ENSEMBL proteins: 
     ENSP00000184266   ENSP00000419578   ENSP00000419128   ENSP00000417714   ENSP00000417755  
    Reactome Protein details: O95168

    NDUFB4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    1 InterPro protein domain:
     IPR009866 NADH_UbQ_OxRdtase_NDUFB4_su

    Graphical View of Domain Structure for InterPro Entry O95168

    ProtoNet protein and cluster: O95168

    1 Blocks protein domain: IPB009866 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4)

    UniProtKB/Swiss-Prot: NDUB4_HUMAN, O95168
    Similarity: Belongs to the complex I NDUFB4 subunit family


    NDUFB4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUB4_HUMAN, O95168
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    NDUFB4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFB4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDUFB4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDUFB4

    miRNA
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    miRTarBase miRNAs that target NDUFB4:
    hsa-mir-26b-5p (MIRT028749)

    Block miRNA regulation of human, mouse, rat NDUFB4 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate NDUFB4:
    hsa-miR-4317 hsa-miR-4311 hsa-miR-196a* hsa-miR-3143 hsa-miR-3924 hsa-miR-630
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDUB4_HUMAN, O95168: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551

    NDUFB4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDUFB4 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Metformin Pathway, Pharmacodynamic
    Metformin Pathway, Pharmacodynamic

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFB4
        Oxidative phosphorylation
    Electron Transport Chain

    1 Reactome Pathway for NDUFB4
        Respiratory electron transport

    1 PharmGKB Pathway for NDUFB4
        Metformin Pathway, Pharmacodynamic

    Selected Kegg Pathways  (Kegg details for NDUFB4) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFB4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFB4: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFB4 (O951683 ENSP000001842664) via UniProtKB, MINT, STRING, and/or I2D (see all 59)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMEP084733I2D: score=2 
    YWHAZP631043I2D: score=1 
    NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
    CYC1ENSP000003171594STRING: ENSP00000317159
    MT-CYBENSP000003545544STRING: ENSP00000354554
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0006979response to oxidative stress IDA12857734
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFB4 (NDUB4)

    8 HMDB Compounds for NDUFB4    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFB4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NDUFB4 gene (2 alternative transcripts): 
    NM_001168331.1  NM_004547.5  

    Unigene Cluster for NDUFB4:

    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
    Hs.304613  [show with all ESTs]
    Unigene Representative Sequence: BM919388
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000184266(uc003edu.3) ENST00000485064(uc003edt.3) ENST00000492739
    ENST00000461682 ENST00000491335 ENST00000496588
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate NDUFB4:
    hsa-miR-4317 hsa-miR-4311 hsa-miR-196a* hsa-miR-3143 hsa-miR-3924 hsa-miR-630
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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      QuantiFast Probe-based Assays in human, mouse, rat NDUFB4

    Additional mRNA sequence: 

    AF044957.1 BC000855.1 BC034579.1 BC070285.1 BC146885.1 BC146887.1 BC146927.1 BC146932.1 

    14 DOTS entries:

    DT.415936  DT.92446955  DT.101986492  DT.100893803  DT.95173313  DT.92446951  DT.95173311  DT.100893802 
    DT.120881650  DT.95173314  DT.121631407  DT.95124152  DT.120881654  DT.120881659 

    Selected AceView cDNA sequences (see all 211):

    BE781781 AI392630 CD674983 BC000855 AI682171 AI802907 AA704675 BG032189 
    BX403252 F26324 CD679082 BF035996 F27624 BM850289 BF732312 BU158802 
    BF529817 F23439 BU164045 BU507845 BX509836 BI820825 AA359165 AA973692 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDUFB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGCTCTGT
    NDUFB4 Expression
    About this image


    NDUFB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
    NDUFB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.304613
        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFB4: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NDUFB4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufb45
    Gm32441
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex 45
    predicted pseudogene 32441
    78.29(n)1
    75.19(a)1
      16 (26.43 cM)5
    1000412731  XM_001476571.41  XP_001476621.11 
     376471705 
    chicken
    (Gallus gallus)
    Aves NDUFB41 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 64.33(n)
    61.4(a)
      769954  XM_001233270.2  XP_001233271.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFB46
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex,...
    61(a)
    1 ↔ 1
    GL343473.1(625623-629990)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ndufb41 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4 60.8(n)
    63.2(a)
      549790  NM_001017036.3  NP_001017036.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndufb41 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 59.62(n)
    54.47(a)
      406306  NM_213033.1  NP_998198.1 


    ENSEMBL Gene Tree for NDUFB4 (if available)
    TreeFam Gene Tree for NDUFB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDUFB4 gene

    NDUFB4 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for NDUFB4 (see all 12)
    PGOHUM00000248272 PGOHUM00000237279 PGOHUM00000244575 PGOHUM00000247543 PGOHUM00000239995


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDUFB4 (see all 199)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1126024491,2
    C,F--120313155(+) CAGGCG/ACCCGC 2 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1903965931,2
    --120313158(+) GCGCCC/TGCCAC 2 -- us2k10--------
    rs2019584071,2
    C--120313176(+) TTTTT-/TGTATT 2 -- us2k10--------
    rs790102841,2
    C--120313218(+) CGTGTA/TAGCCA 2 -- us2k10--------
    rs1467635451,2
    --120313228(+) AGGATG/TGTCTT 2 -- us2k10--------
    rs1826994631,2
    --120313302(+) CCACCA/GCGCCC 2 -- us2k10--------
    rs1403679181,2
    --120313407(+) CACGGC/TTGTGA 2 -- us2k10--------
    rs1877947771,2
    --120313533(+) TGGGGA/CTCGCC 2 -- us2k10--------
    rs1503530961,2
    --120313671(+) TATAAA/CCTGCT 2 -- us2k10--------
    rs2000407861,2
    --120313790(+) GTTCA-/TTTTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for NDUFB4 (120315128 - 120321347 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NDUFB4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272005CNV Insertion20981092
    esv272279CNV Insertion20981092
    nsv829699CNV Loss17160897
    nsv508238CNV Loss20534489
    nsv877377CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603840    OMIM disorders: --

    9 diseases for NDUFB4:    
    About MalaCards
    mumps    rubella    huntington's disease    fatty liver disease
    parkinson's disease    liver disease    alzheimer's disease    prostate cancer
    prostatitis


    NDUFB4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NDUFB4
    Human Genome Epidemiology (HuGE) Navigator: NDUFB4 (2 documents)

    Export disorders for NDUFB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDUFB4 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with NDUFB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2, 3 Loeffen J.L.C.M.... Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (Mol. Cell. Biol. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4710 HGNC: 7699 AceView: NDUFB4 Ensembl:ENSG00000065518 euGenes: HUgn4710
    ECgene: NDUFB4 Kegg: 4710 H-InvDB: NDUFB4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NDUFB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NDUFB4 gene:
    Search GeneIP for patents involving NDUFB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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