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Aliases for NDUFB4 Gene

Aliases for NDUFB4 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 4, 15kDa 2 3
  • NADH-Ubiquinone Oxidoreductase B15 Subunit 3 4
  • Complex I B15 Subunit 2 3
  • Complex I-B15 3 4
  • CI-B15 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 4 (15kD, B15) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 4 3
  • B15 3

External Ids for NDUFB4 Gene

Summaries for NDUFB4 Gene

Entrez Gene Summary for NDUFB4 Gene

  • This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]

GeneCards Summary for NDUFB4 Gene

NDUFB4 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 4, 15kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB4 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB4 Gene

Genomics for NDUFB4 Gene

Genomic Location for NDUFB4 Gene

Start:
120,596,281 bp from pter
End:
120,602,500 bp from pter
Size:
6,220 bases
Orientation:
Plus strand

Genomic View for NDUFB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB4 Gene

Regulatory Elements for NDUFB4 Gene

Proteins for NDUFB4 Gene

  • Protein details for NDUFB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95168-NDUB4_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4
    Protein Accession:
    O95168
    Secondary Accessions:
    • B2RUY3
    • B9EJC7

    Protein attributes for NDUFB4 Gene

    Size:
    129 amino acids
    Molecular mass:
    15209 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB4 Gene

Proteomics data for NDUFB4 Gene at MOPED

Post-translational modifications for NDUFB4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5

Other Protein References for NDUFB4 Gene

No data available for DME Specific Peptides for NDUFB4 Gene

Domains for NDUFB4 Gene

Gene Families for NDUFB4 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB4 Gene

UniProtKB/Swiss-Prot:

NDUB4_HUMAN
Family:
  • Belongs to the complex I NDUFB4 subunit family.:
    • O95168
genes like me logo Genes that share domains with NDUFB4: view

Function for NDUFB4 Gene

Molecular function for NDUFB4 Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB4: view

miRNA for NDUFB4 Gene

miRTarBase miRNAs that target NDUFB4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFB4 Gene

Localization for NDUFB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB4 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB4 Gene COMPARTMENTS Subcellular localization image for NDUFB4 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NDUFB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
genes like me logo Genes that share ontologies with NDUFB4: view

Pathways for NDUFB4 Gene

genes like me logo Genes that share pathways with NDUFB4: view

Gene Ontology (GO) - Biological Process for NDUFB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0006979 response to oxidative stress IDA 12857734
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB4: view

Compounds for NDUFB4 Gene

(8) HMDB Compounds for NDUFB4 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB4 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB4: view

Transcripts for NDUFB4 Gene

Unigene Clusters for NDUFB4 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB4 Gene

No ASD Table

Relevant External Links for NDUFB4 Gene

GeneLoc Exon Structure for
NDUFB4
ECgene alternative splicing isoforms for
NDUFB4

Expression for NDUFB4 Gene

mRNA expression in normal human tissues for NDUFB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB4 Gene

SOURCE GeneReport for Unigene cluster for NDUFB4 Gene Hs.304613

genes like me logo Genes that share expressions with NDUFB4: view

Orthologs for NDUFB4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB4 36
  • 100 (n)
  • 100 (a)
NDUFB4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 71 (a)
OneToMany
NDUFB4 36
  • 82.69 (n)
  • 73.64 (a)
NDUFB4 37
  • 73 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NDUFB4 36
  • 84.11 (n)
  • 78.91 (a)
NDUFB4 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm3244 36
  • 78.29 (n)
  • 75.19 (a)
Ndufb4 16
Ndufb4 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB4 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb4 36
  • 78.29 (n)
  • 73.64 (a)
chicken
(Gallus gallus)
Aves NDUFB4 36
  • 64.33 (n)
  • 61.4 (a)
NDUFB4 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB4 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb4 36
  • 60.8 (n)
  • 63.2 (a)
zebrafish
(Danio rerio)
Actinopterygii ndufb4 36
  • 59.62 (n)
  • 54.47 (a)
Species with no ortholog for NDUFB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB4 Gene

ENSEMBL:
Gene Tree for NDUFB4 (if available)
TreeFam:
Gene Tree for NDUFB4 (if available)

Paralogs for NDUFB4 Gene

genes like me logo Genes that share paralogs with NDUFB4: view

No data available for Paralogs for NDUFB4 Gene

Variants for NDUFB4 Gene

Sequence variations from dbSNP and Humsavar for NDUFB4 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs12762 -- 120,602,092(+) TTGTA(C/T)GGTGG utr-variant-3-prime, intron-variant
rs701991 -- 120,600,091(+) AACGG(A/G)AGCAT intron-variant
rs804970 -- 120,601,910(-) CCATA(C/T)ATTGA utr-variant-3-prime, intron-variant
rs804985 -- 120,598,115(-) agatc(A/G)tacca intron-variant
rs804986 -- 120,597,303(-) ATATA(C/T)GAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB4 Gene

Variant ID Type Subtype PubMed ID
nsv508238 CNV Loss 20534489
nsv877377 CNV Gain 21882294
nsv829699 CNV Loss 17160897
esv272279 CNV Insertion 20981092
esv272005 CNV Insertion 20981092

Relevant External Links for NDUFB4 Gene

HapMap Linkage Disequilibrium report
NDUFB4

Disorders for NDUFB4 Gene

Relevant External Links for NDUFB4

Genetic Association Database (GAD)
NDUFB4
Human Genome Epidemiology (HuGE) Navigator
NDUFB4
genes like me logo Genes that share disorders with NDUFB4: view

No data available for UniProtKB/Swiss-Prot for NDUFB4 Gene

Publications for NDUFB4 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for NDUFB4 Gene

Sources for NDUFB4 Gene

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