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NDUFB3 Gene

protein-coding   GIFtS: 56
GCID: GC02P201936

NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 3, 12kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3 (12kD,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 3, 12kDa1 2     Complex I B12 Subunit1
Complex I-B122 3     NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 3 (12kD, B12)1
CI-B122 3     B122
NADH-Ubiquinone Oxidoreductase B12 Subunit2 3     NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 32

External Ids:    HGNC: 76981   Entrez Gene: 47092   Ensembl: ENSG000001190137   OMIM: 6038395   UniProtKB: O436763   

Export aliases for NDUFB3 gene to outside databases

Previous GC identifers: GC02P200153 GC02P200661 GC02P201900 GC02P202139 GC02P201762 GC02P201644 GC02P193787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDUFB3 Gene:
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex
I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner
membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to
mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the
same protein. Humans have multiple pseudogenes of this gene. (provided by RefSeq, Mar 2012)

GeneCards Summary for NDUFB3 Gene:
NDUFB3 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa) is a protein-coding gene. Diseases associated with NDUFB3 include mitochondrial complex i deficiency, and lateral sclerosis. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NDUB3_HUMAN, O43676
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFB3 gene promoter:
         AML1a   NF-YA   POU6F1 (c2)   NF-YB   HEN1   CBF-B   CBF-A   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFB3 promoter sequence
   Search Chromatin IP Primers for NDUFB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.3   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33.1

NDUFB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFB3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P201936:  view genomic region     (about GC identifiers)

Start:
201,936,156 bp from pter      End:
201,950,473 bp from pter
Size:
14,318 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NDUB3_HUMAN, O43676 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3  
Size: 98 amino acids; 11402 Da
Subunit: Complex I is composed of 45 different subunits
Secondary accessions: Q6IB80

Explore the universe of human proteins at neXtProt for NDUFB3: NX_O43676

Explore proteomics data for NDUFB3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NDUFB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001244031.1  NP_002482.1  

    ENSEMBL proteins: 
     ENSP00000401834   ENSP00000237889   ENSP00000410600   ENSP00000407336  
    Reactome Protein details: O43676

    NDUFB3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    1 InterPro protein domain:
     IPR012576 NDUFB3

    Graphical View of Domain Structure for InterPro Entry O43676

    ProtoNet protein and cluster: O43676

    1 Blocks protein domain: IPB012576 NADH-ubiquinone oxidoreductase B12 subunit

    UniProtKB/Swiss-Prot: NDUB3_HUMAN, O43676
    Similarity: Belongs to the complex I NDUFB3 subunit family


    NDUFB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUB3_HUMAN, O43676
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    NDUFB3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFB3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDUFB3

    miRNA
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    miRTarBase miRNAs that target NDUFB3:
    hsa-mir-18a-3p (MIRT040891)

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDUB3_HUMAN, O43676: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    extracellular1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0016021integral component of membrane IEA--

    NDUFB3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDUFB3 About    
    See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Oxidative phosphorylation0.64
    Respiratory electron transport0.81
    Parkinson's disease0.57
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NDUFB3
        Electron Transport Chain

    1 Reactome Pathway for NDUFB3
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for NDUFB3) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFB3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFB3: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFB3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFB3 (O436762, 3 ENSP000002378894) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP5C1P365422, 3, ENSP000003491424MINT-63700 I2D: score=5 STRING: ENSP00000349142
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
    CYC1ENSP000003171594STRING: ENSP00000317159
    MT-ND1ENSP000003546874STRING: ENSP00000354687
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0022900electron transport chain ----
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFB3 (NDUB3)

    8 HMDB Compounds for NDUFB3    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFB3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NDUFB3 gene (2 alternative transcripts): 
    NM_001257102.1  NM_002491.2  

    Unigene Cluster for NDUFB3:

    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
    Hs.109760  [show with all ESTs]
    Unigene Representative Sequence: BM552702
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450023 ENST00000237889(uc002uwx.4) ENST00000433898 ENST00000454214


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    Additional mRNA sequence: 

    AF035839.1 AF047183.1 BC018183.1 CR456924.1 

    10 DOTS entries:

    DT.447331  DT.99956714  DT.120963492  DT.97784860  DT.95092387  DT.100692775  DT.95092411  DT.91743226 
    DT.91743227  DT.91841399 

    Selected AceView cDNA sequences (see all 256):

    AA883278 BM673734 BM724744 AA845535 BM786109 AA776653 AA932871 BQ188397 
    F36305 AA384898 AI148568 AA634495 BC018183 AA291055 BM848639 BG387988 
    BM127464 CK299659 BM712878 AA040759 AI274355 AI346304 AA156774 AW008598 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDUFB3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTGGCTTTG
    NDUFB3 Expression
    About this image


    NDUFB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Eye (Sensory Organs)
             Lens
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Colon (Gastrointestinal Tract)
    NDUFB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFB3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.109760
        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFB3: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NDUFB3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufb31 , 5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex 31, 5 82.95(n)1
    81.4(a)1
      1 (29.13 cM)5
    664951  NM_025597.21  NP_079873.11 
     585863845 
    chicken
    (Gallus gallus)
    Aves NDUFB31 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 67.83(n)
    66.28(a)
      424078  XM_001232007.3  XP_001232008.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFB36
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex,...
    63(a)
    1 ↔ 1
    GL343478.1(445742-449601)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.195602 Xenopus laevis transcribed sequence with weak similarity more 72.28(n)    AW637187.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003320341 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit more 61.04(n)
    65.06(a)
      100332034  XM_002663290.3  XP_002663336.1 


    ENSEMBL Gene Tree for NDUFB3 (if available)
    TreeFam Gene Tree for NDUFB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDUFB3 gene

    NDUFB3 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for NDUFB3
    PGOHUM00000250146 PGOHUM00000250154 PGOHUM00000251068 PGOHUM00000250090


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDUFB3 (see all 287)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476873571,2
    C--201324154(+) AGAAC-/AAAAAC 2 -- us2k10--------
    rs761526101,2
    F--201324409(+) CACTAC/TATTAG 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1922570061,2
    C--201324426(+) TCTCCC/TAAGCT 2 -- us2k10--------
    rs1852688501,2
    --201324564(+) TTCCAC/TAACAC 2 -- us2k10--------
    rs41477851,2
    C,F,H--201324788(+) TTTCTG/ACCRGG 2 -- us2k110Minor allele frequency- A:0.02NS EA NA 1552
    rs1880901151,2
    --201324789(+) TTCTGC/GCGGGC 2 -- us2k10--------
    rs1928761831,2
    C--201324867(+) AGTTCC/GAGACC 2 -- us2k10--------
    rs1845989511,2
    --201324919(+) CAAAAA/TTAGTC 2 -- us2k10--------
    rs790530271,2
    C--201325039(+) CTCCAG/TCCTGG 2 -- us2k10--------
    rs747973511,2
    C,F--201325093(+) TTTTTT/CCCCCA 2 -- us2k12Minor allele frequency- C:0.13WA 120

    HapMap Linkage Disequilibrium report for NDUFB3 (201936156 - 201950473 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NDUFB3: --
    Human Gene Mutation Database (HGMD): NDUFB3
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NDUFB3
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFB3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603839   
    OMIM disorders: 252010  
    9 diseases for NDUFB3:    
    About MalaCards
    mitochondrial complex i deficiency    lateral sclerosis    amyotrophic lateral sclerosis    huntington's disease
    fatty liver disease    parkinson's disease    liver disease    alzheimer's disease
    cerebritis

    1 disease from the University of Copenhagen DISEASES database for NDUFB3:
    Leigh disease

    NDUFB3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NDUFB3
    Human Genome Epidemiology (HuGE) Navigator: NDUFB3 (2 documents)

    Export disorders for NDUFB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDUFB3 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with NDUFB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PubMed id 9425316)1, 2, 3 Ton C.... Liew C.-C. (Biochem. Biophys. Res. Commun. 1997)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    6. Assignment of human NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 (NDUFB3) and of its four pseudogenes to human chromosomes 2q31.3, 1p13.3--&gt;p13.1, 9q32--&gt;q34.1, 14q22.3--&gt;q23.1 and 14q32.2 by radiation hybrid mapping. (PubMed id 11474204)1, 3 Jensen L.L....Hansen L.L. (Cytogenet. Cell Genet. 2001)
    7. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2 Loeffen J.L.C.M.... Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998)
    8. Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. (PubMed id 22277967)1 Calvo S.E.... Mootha V.K. (Sci. Transl. Med. 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4709 HGNC: 7698 AceView: NDUFB3 Ensembl:ENSG00000119013 euGenes: HUgn4709
    ECgene: NDUFB3 Kegg: 4709 H-InvDB: NDUFB3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDUFB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NDUFB3 gene:
    Search GeneIP for patents involving NDUFB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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