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Aliases for NDUFB3 Gene

Aliases for NDUFB3 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 3, 12kDa 2 3
  • NADH-Ubiquinone Oxidoreductase B12 Subunit 3 4
  • Complex I-B12 3 4
  • CI-B12 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 3 (12kD, B12) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 3 3
  • Complex I B12 Subunit 2
  • B12 3

External Ids for NDUFB3 Gene

Previous GeneCards Identifiers for NDUFB3 Gene

  • GC02P200153
  • GC02P200661
  • GC02P201900
  • GC02P202139
  • GC02P201762
  • GC02P201644
  • GC02P201936
  • GC02P193787

Summaries for NDUFB3 Gene

Entrez Gene Summary for NDUFB3 Gene

  • This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for NDUFB3 Gene

NDUFB3 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 3, 12kDa) is a Protein Coding gene. Diseases associated with NDUFB3 include mitochondrial complex i deficiency. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB3 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB3 Gene

Genomics for NDUFB3 Gene

Regulatory Elements for NDUFB3 Gene

Genomic Location for NDUFB3 Gene

Start:
201,071,433 bp from pter
End:
201,085,750 bp from pter
Size:
14,318 bases
Orientation:
Plus strand

Genomic View for NDUFB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB3 Gene

Proteins for NDUFB3 Gene

  • Protein details for NDUFB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43676-NDUB3_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
    Protein Accession:
    O43676
    Secondary Accessions:
    • Q6IB80

    Protein attributes for NDUFB3 Gene

    Size:
    98 amino acids
    Molecular mass:
    11402 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

neXtProt entry for NDUFB3 Gene

Proteomics data for NDUFB3 Gene at MOPED

Post-translational modifications for NDUFB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFB3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB3 Gene

Domains for NDUFB3 Gene

Gene Families for NDUFB3 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB3 Gene

Suggested Antigen Peptide Sequences for NDUFB3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43676

UniProtKB/Swiss-Prot:

NDUB3_HUMAN :
  • O43676
Family:
  • Belongs to the complex I NDUFB3 subunit family.
genes like me logo Genes that share domains with NDUFB3: view

Function for NDUFB3 Gene

Molecular function for NDUFB3 Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB3: view

miRNA for NDUFB3 Gene

miRTarBase miRNAs that target NDUFB3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFB3 Gene

Localization for NDUFB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB3 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB3 Gene COMPARTMENTS Subcellular localization image for NDUFB3 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NDUFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NDUFB3: view

Pathways for NDUFB3 Gene

genes like me logo Genes that share pathways with NDUFB3: view

Gene Ontology (GO) - Biological Process for NDUFB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022900 electron transport chain --
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB3: view

Compounds for NDUFB3 Gene

(8) HMDB Compounds for NDUFB3 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB3: view

Transcripts for NDUFB3 Gene

Unigene Clusters for NDUFB3 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB3 Gene

No ASD Table

Relevant External Links for NDUFB3 Gene

GeneLoc Exon Structure for
NDUFB3
ECgene alternative splicing isoforms for
NDUFB3

Expression for NDUFB3 Gene

mRNA expression in normal human tissues for NDUFB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFB3 Gene

This gene is overexpressed in Heart - Left Ventricle (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB3 Gene

SOURCE GeneReport for Unigene cluster for NDUFB3 Gene Hs.109760

genes like me logo Genes that share expressions with NDUFB3: view

No data available for mRNA Expression by UniProt/SwissProt for NDUFB3 Gene

Orthologs for NDUFB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB3 35
  • 100 (n)
  • 100 (a)
NDUFB3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB3 35
  • 89.46 (n)
  • 82.65 (a)
NDUFB3 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB3 35
  • 89.8 (n)
  • 81.63 (a)
NDUFB3 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufb3 35
  • 82.95 (n)
  • 81.4 (a)
Ndufb3 16
Ndufb3 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB3 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB3 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb3 35
  • 82.75 (n)
  • 80 (a)
chicken
(Gallus gallus)
Aves NDUFB3 35
  • 67.83 (n)
  • 66.28 (a)
NDUFB3 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB3 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19560 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb3 35
  • 65.5 (n)
  • 70.93 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332034 35
  • 61.04 (n)
  • 65.06 (a)
ndufb3 36
  • 63 (a)
OneToOne
Species with no ortholog for NDUFB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB3 Gene

ENSEMBL:
Gene Tree for NDUFB3 (if available)
TreeFam:
Gene Tree for NDUFB3 (if available)

Paralogs for NDUFB3 Gene

Pseudogenes.org Pseudogenes for NDUFB3 Gene

genes like me logo Genes that share paralogs with NDUFB3: view

No data available for Paralogs for NDUFB3 Gene

Variants for NDUFB3 Gene

Sequence variations from dbSNP and Humsavar for NDUFB3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4674670 -- 201,075,590(+) aaaGG(G/T)ATATT intron-variant
rs4674672 -- 201,079,546(+) taagc(A/G)atcct intron-variant
rs7565481 -- 201,083,145(+) ttttt(C/T)ttgca intron-variant
rs7570788 -- 201,086,110(+) GCCTC(C/T)CAAGT downstream-variant-500B
rs10166874 -- 201,083,691(+) ttttt(A/C)tgcat intron-variant

Relevant External Links for NDUFB3 Gene

HapMap Linkage Disequilibrium report
NDUFB3
Human Gene Mutation Database (HGMD)
NDUFB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFB3 Gene

Disorders for NDUFB3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NDUFB3 Gene including...

Search for NDUFB3 Gene in MalaCards »

(1) OMIM Diseases for NDUFB3 Gene (603839)

(1) University of Copenhagen DISEASES for NDUFB3 Gene

Relevant External Links for NDUFB3

Genetic Association Database (GAD)
NDUFB3
Human Genome Epidemiology (HuGE) Navigator
NDUFB3
genes like me logo Genes that share disorders with NDUFB3: view

No data available for UniProtKB/Swiss-Prot for NDUFB3 Gene

Publications for NDUFB3 Gene

  1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C. … Liew C.-C. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  2. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 3 4
  3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48

Products for NDUFB3 Gene

  • antibodies-online proteins for NDUFB3
  • antibodies-online antibodies for NDUFB3
  • antibodies-online kits for NDUFB3

Sources for NDUFB3 Gene

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