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Aliases for NDUFB2 Gene

Aliases for NDUFB2 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B2 2 3 5
  • NADH-Ubiquinone Oxidoreductase AGGG Subunit 2 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 2, 8kDa 2 3
  • Complex I AGGG Subunit 2 3
  • Complex I-AGGG 3 4
  • CI-AGGG 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 2, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 2 (8kD, AGGG) 2
  • AGGG 3

External Ids for NDUFB2 Gene

Previous GeneCards Identifiers for NDUFB2 Gene

  • GC07P138667
  • GC07P139726
  • GC07P139803
  • GC07P139849
  • GC07P140042
  • GC07P140390
  • GC07P134692

Summaries for NDUFB2 Gene

Entrez Gene Summary for NDUFB2 Gene

  • The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]

GeneCards Summary for NDUFB2 Gene

NDUFB2 (NADH:Ubiquinone Oxidoreductase Subunit B2) is a Protein Coding gene. Diseases associated with NDUFB2 include Intraneural Perineurioma. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB2 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB2 Gene

Genomics for NDUFB2 Gene

Regulatory Elements for NDUFB2 Gene

Enhancers for NDUFB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F140695 0.4 ENCODE 17.8 +6.2 6171 2.9 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NDUFB2 CCT4P1 RNU4-74P ENSG00000270157 TMEM178B ADCK2 NDUFB2-AS1
GH07F140923 0.2 ENCODE 17.8 +233.8 233847 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 NDUFB2 MRPS33 TAS2R6P NDUFB2-AS1 ADCK2 BRAF RNU6-85P
GH07F140630 0.2 ENCODE 12 -59.0 -59049 1.5 ZNF121 PKNOX1 POLR2A SMARCA4 ADCK2 DENND2A NDUFB2 LOC105375535 GC07P140619
GH07F140635 1.3 Ensembl ENCODE 12 -54.8 -54816 1.2 NR2F2 ADCK2 DENND2A NDUFB2 NDUFB2-AS1 TMEM178B LOC105375535 GC07P140619
GH07F140621 1.3 FANTOM5 Ensembl ENCODE 11.9 -65.4 -65378 8.2 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 FEZF1 ZNF2 DENND2A ADCK2 NDUFB2 BRAF TMEM178B GC07P140619 LOC105375535
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NDUFB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDUFB2 Gene

Chromosome:
7
Start:
140,690,777 bp from pter
End:
140,722,790 bp from pter
Size:
32,014 bases
Orientation:
Plus strand

Genomic View for NDUFB2 Gene

Genes around NDUFB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB2 Gene

Proteins for NDUFB2 Gene

  • Protein details for NDUFB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95178-NDUB2_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
    Protein Accession:
    O95178
    Secondary Accessions:
    • Q6FGI6

    Protein attributes for NDUFB2 Gene

    Size:
    105 amino acids
    Molecular mass:
    12058 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

neXtProt entry for NDUFB2 Gene

Post-translational modifications for NDUFB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDUFB2 Gene

Domains & Families for NDUFB2 Gene

Protein Domains for NDUFB2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFB2 Gene

Graphical View of Domain Structure for InterPro Entry

O95178

UniProtKB/Swiss-Prot:

NDUB2_HUMAN :
  • Belongs to the complex I NDUFB2 subunit family.
Family:
  • Belongs to the complex I NDUFB2 subunit family.
genes like me logo Genes that share domains with NDUFB2: view

Function for NDUFB2 Gene

Molecular function for NDUFB2 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),12.1kDa,component beta 2,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB2: view

Phenotypes for NDUFB2 Gene

genes like me logo Genes that share phenotypes with NDUFB2: view

Animal Model Products

miRNA for NDUFB2 Gene

miRTarBase miRNAs that target NDUFB2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB2 Gene

Localization for NDUFB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB2 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB2 Gene COMPARTMENTS Subcellular localization image for NDUFB2 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NDUFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0005747 mitochondrial respiratory chain complex I IEA,NAS 9878551
GO:0016020 membrane IEA --
GO:0070469 respiratory chain IEA --
genes like me logo Genes that share ontologies with NDUFB2: view

Pathways & Interactions for NDUFB2 Gene

genes like me logo Genes that share pathways with NDUFB2: view

Gene Ontology (GO) - Biological Process for NDUFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB2: view

No data available for SIGNOR curated interactions for NDUFB2 Gene

Drugs & Compounds for NDUFB2 Gene

(5) Drugs for NDUFB2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFB2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFB2: view

Transcripts for NDUFB2 Gene

Unigene Clusters for NDUFB2 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for NDUFB2 Gene

GeneLoc Exon Structure for
NDUFB2
ECgene alternative splicing isoforms for
NDUFB2

Expression for NDUFB2 Gene

mRNA expression in normal human tissues for NDUFB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFB2 Gene

This gene is overexpressed in Nasal epithelium (63.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NDUFB2 Gene



NURSA nuclear receptor signaling pathways regulating expression of NDUFB2 Gene:

NDUFB2

SOURCE GeneReport for Unigene cluster for NDUFB2 Gene:

Hs.655788
genes like me logo Genes that share expression patterns with NDUFB2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NDUFB2 Gene

Orthologs for NDUFB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB2 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia NDUFB2 34 35
  • 86.67 (n)
cow
(Bos Taurus)
Mammalia NDUFB2 34 35
  • 85.4 (n)
mouse
(Mus musculus)
Mammalia Ndufb2 34 16 35
  • 81.9 (n)
rat
(Rattus norvegicus)
Mammalia Ndufb2 34
  • 80 (n)
oppossum
(Monodelphis domestica)
Mammalia NDUFB2 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFB2 34
  • 67.02 (n)
lizard
(Anolis carolinensis)
Reptilia NDUFB2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb2 34
  • 62.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia ndufb2-prov 34
zebrafish
(Danio rerio)
Actinopterygii zgc:73329 34
  • 60.48 (n)
NDUFB2 35
  • 51 (a)
OneToOne
Species where no ortholog for NDUFB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB2 Gene

ENSEMBL:
Gene Tree for NDUFB2 (if available)
TreeFam:
Gene Tree for NDUFB2 (if available)

Paralogs for NDUFB2 Gene

(1) SIMAP similar genes for NDUFB2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for NDUFB2 Gene

genes like me logo Genes that share paralogs with NDUFB2: view

No data available for Paralogs for NDUFB2 Gene

Variants for NDUFB2 Gene

Sequence variations from dbSNP and Humsavar for NDUFB2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10226979 -- 140,706,550(+) ACTTT(G/T)GTTTT intron-variant
rs10230071 -- 140,706,840(+) GCGCC(C/T)GCCAC downstream-variant-500B
rs10230163 -- 140,706,848(+) CACCA(C/T)GCCTG downstream-variant-500B
rs10246972 -- 140,699,414(+) AGGCt(A/C)acatt intron-variant
rs1046515 -- 140,694,787(+) GGGCC(C/T)AGTGT upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NDUFB2 Gene

Variant ID Type Subtype PubMed ID
nsv1115016 CNV deletion 24896259
nsv831157 CNV gain 17160897
nsv831158 CNV loss 17160897

Variation tolerance for NDUFB2 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB2 Gene

Disorders for NDUFB2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NDUFB2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intraneural perineurioma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NDUFB2

Genetic Association Database (GAD)
NDUFB2
Human Genome Epidemiology (HuGE) Navigator
NDUFB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFB2
genes like me logo Genes that share disorders with NDUFB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDUFB2 Gene

Publications for NDUFB2 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4 64

Products for NDUFB2 Gene

Sources for NDUFB2 Gene

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