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Aliases for NDUFB2 Gene

Aliases for NDUFB2 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 2, 8kDa 2 3
  • NADH-Ubiquinone Oxidoreductase AGGG Subunit 2 3 4
  • Complex I AGGG Subunit 2 3
  • Complex I-AGGG 3 4
  • CI-AGGG 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 2, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 2 (8kD, AGGG) 2
  • AGGG 3

External Ids for NDUFB2 Gene

Previous GeneCards Identifiers for NDUFB2 Gene

  • GC07P138667
  • GC07P139726
  • GC07P139803
  • GC07P139849
  • GC07P140042
  • GC07P140390
  • GC07P134692

Summaries for NDUFB2 Gene

Entrez Gene Summary for NDUFB2 Gene

  • The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]

GeneCards Summary for NDUFB2 Gene

NDUFB2 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 2, 8kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB2 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB2 Gene

Genomics for NDUFB2 Gene

Regulatory Elements for NDUFB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDUFB2 Gene

Start:
140,690,777 bp from pter
End:
140,722,790 bp from pter
Size:
32,014 bases
Orientation:
Plus strand

Genomic View for NDUFB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB2 Gene

Proteins for NDUFB2 Gene

  • Protein details for NDUFB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95178-NDUB2_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
    Protein Accession:
    O95178
    Secondary Accessions:
    • Q6FGI6

    Protein attributes for NDUFB2 Gene

    Size:
    105 amino acids
    Molecular mass:
    12058 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

neXtProt entry for NDUFB2 Gene

Proteomics data for NDUFB2 Gene at MOPED

Post-translational modifications for NDUFB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDUFB2 Gene

Domains for NDUFB2 Gene

Gene Families for NDUFB2 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFB2 Gene

Graphical View of Domain Structure for InterPro Entry

O95178

UniProtKB/Swiss-Prot:

NDUB2_HUMAN :
  • O95178
Family:
  • Belongs to the complex I NDUFB2 subunit family.
genes like me logo Genes that share domains with NDUFB2: view

Function for NDUFB2 Gene

Molecular function for NDUFB2 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),12.1kDa,component beta 2,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB2: view

Animal Model Products

CRISPR Products

miRNA for NDUFB2 Gene

miRTarBase miRNAs that target NDUFB2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFB2 Gene

Localization for NDUFB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB2 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB2 Gene COMPARTMENTS Subcellular localization image for NDUFB2 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NDUFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
genes like me logo Genes that share ontologies with NDUFB2: view

Pathways for NDUFB2 Gene

genes like me logo Genes that share pathways with NDUFB2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NDUFB2 Gene

Gene Ontology (GO) - Biological Process for NDUFB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB2: view

Compounds for NDUFB2 Gene

(8) HMDB Compounds for NDUFB2 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB2: view

Transcripts for NDUFB2 Gene

Unigene Clusters for NDUFB2 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - -
SP3: - -
SP4: -

Relevant External Links for NDUFB2 Gene

GeneLoc Exon Structure for
NDUFB2
ECgene alternative splicing isoforms for
NDUFB2

Expression for NDUFB2 Gene

mRNA expression in normal human tissues for NDUFB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NDUFB2 Gene

SOURCE GeneReport for Unigene cluster for NDUFB2 Gene Hs.655788

genes like me logo Genes that share expressions with NDUFB2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFB2 Gene

Orthologs for NDUFB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB2 35
  • 99.37 (n)
  • 98.1 (a)
NDUFB2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB2 35
  • 85.4 (n)
  • 83.81 (a)
NDUFB2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB2 35
  • 86.67 (n)
  • 84.76 (a)
NDUFB2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufb2 35
  • 81.9 (n)
  • 82.86 (a)
Ndufb2 16
Ndufb2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB2 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb2 35
  • 80 (n)
  • 76.19 (a)
chicken
(Gallus gallus)
Aves NDUFB2 35
  • 67.02 (n)
  • 72.63 (a)
lizard
(Anolis carolinensis)
Reptilia NDUFB2 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ndufb2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb2 35
  • 62.75 (n)
  • 63.73 (a)
zebrafish
(Danio rerio)
Actinopterygii NDUFB2 36
  • 51 (a)
OneToOne
zgc:73329 35
  • 60.48 (n)
  • 52.58 (a)
Species with no ortholog for NDUFB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB2 Gene

ENSEMBL:
Gene Tree for NDUFB2 (if available)
TreeFam:
Gene Tree for NDUFB2 (if available)

Paralogs for NDUFB2 Gene

Selected SIMAP similar genes for NDUFB2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for NDUFB2 Gene

genes like me logo Genes that share paralogs with NDUFB2: view

No data available for Paralogs for NDUFB2 Gene

Variants for NDUFB2 Gene

Sequence variations from dbSNP and Humsavar for NDUFB2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs11852 -- 140,702,942(-) GAACT(C/T)GCTCT missense, reference
rs2072415 -- 140,702,582(+) GGGCT(A/G)GCACC intron-variant
rs2364396 -- 140,705,760(+) CAGTA(C/T)GTAGC intron-variant
rs2364397 -- 140,705,906(+) CAAGA(A/G)TTTTT intron-variant
rs2968548 -- 140,706,699(-) ccctc(C/G)cacca downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NDUFB2 Gene

Variant ID Type Subtype PubMed ID
nsv831157 CNV Gain 17160897
nsv831158 CNV Loss 17160897

Relevant External Links for NDUFB2 Gene

HapMap Linkage Disequilibrium report
NDUFB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB2 Gene

Disorders for NDUFB2 Gene

Relevant External Links for NDUFB2

Genetic Association Database (GAD)
NDUFB2
Human Genome Epidemiology (HuGE) Navigator
NDUFB2
genes like me logo Genes that share disorders with NDUFB2: view

No data available for UniProtKB/Swiss-Prot for NDUFB2 Gene

Publications for NDUFB2 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  4. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NDUFB2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDUFB2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB2
    • Block miRNA regulation of NDUFB2 using miScript Target Protectors

    Sources for NDUFB2 Gene

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