Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDUFB11 Gene

protein-coding   GIFtS: 53
GCID: GC0XM047001

NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 11, 17.3kDa

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 11, 17.3kDa1 2     NP17.32
Complex I NP17.3 Subunit1 2     Np152
Complex I-ESSS2 3     P17.32
Neuronal Protein 17.32 3     NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 11,
Mitochondrial2
CI-ESSS2 3     Np17.33
NADH-Ubiquinone Oxidoreductase ESSS Subunit2 3     p17.33
ESSS2     

External Ids:    HGNC: 203721   Entrez Gene: 545392   Ensembl: ENSG000001471237   OMIM: 3004035   UniProtKB: Q9NX143   
ORGUL members:         
NONCODE14:n406783      

Export aliases for NDUFB11 gene to outside databases

Previous GC identifers: GC0XM046757 GC0XM046886 GC0XM044714


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NDUFB11 Gene:
NDUFB11 is a component of mitochondrial complex I. Complex I catalyzes the first step in the electron transport
chain, the transfer of 2 electrons from NADH to ubiquinone, coupled to the translocation of 4 protons across the
membrane (Carroll et al., 2002 (PubMed 12381726)).(supplied by OMIM, Feb 2009)

GeneCards Summary for NDUFB11 Gene: 
NDUFB11 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NDUFB11 include stiff-person syndrome, and lewy body dementia, and among its related super-pathways are Electron Transport Chain and Metabolic pathways.

UniProtKB/Swiss-Prot: NDUBB_HUMAN, Q9NX14
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_079573.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDUFB11 gene promoter:
         ER-alpha   C/EBPbeta   p53   MyoD   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFB11 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDUFB11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFB11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.3

NDUFB11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFB11 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM047001:  view genomic region     (about GC identifiers)

Start:
47,001,615 bp from pter      End:
47,004,903 bp from pter
Size:
3,289 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDUBB_HUMAN, Q9NX14 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial precursor  
Size: 153 amino acids; 17317 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein (Potential)
Secondary accessions: Q5JRR3 Q5JRR4 Q6IAB6 Q8WZ96 Q9BXX9
Alternative splicing: 2 isoforms:  Q9NX14-1   Q9NX14-2   

Explore the universe of human proteins at neXtProt for NDUFB11: NX_Q9NX14

Explore proteomics data for NDUFB11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NX14

  • NDUFB11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDUFB11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129470.1  NP_061929.2  

    ENSEMBL proteins: 
     ENSP00000367042   ENSP00000276062  
    Reactome Protein details: Q9NX14
    Human Recombinant Protein Products for NDUFB11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NDUFB11
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NDUFB11
    GenScript Custom Purified and Recombinant Proteins Services for NDUFB11
    Novus Biologicals NDUFB11 Protein
    Novus Biologicals NDUFB11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I IDA12611891
    GO:0016021integral to membrane IEA--

    NDUFB11 for ontologies           About GeneDecksing



    NDUFB11 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NDUFB11
    GenScript Custom Superior Antibodies Services for NDUFB11
    Novus Biologicals NDUFB11 Antibodies
    Abcam antibodies for NDUFB11
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for NDUFB11
    Search LSBio for Antibodies for NDUFB11 

    Assay Products for NDUFB11: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NDUFB11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NDUFB11
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comI: Mitochondrial respiratory chain complex / Complex I

    1 InterPro protein domain:
     IPR019329 NADH_UbQ_OxRdtase_ESSS_su

    Graphical View of Domain Structure for InterPro Entry Q9NX14

    ProtoNet protein and cluster: Q9NX14

    UniProtKB/Swiss-Prot: NDUBB_HUMAN, Q9NX14
    Similarity: Belongs to the complex I NDUFB11 subunit family


    NDUFB11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUBB_HUMAN, Q9NX14
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

    Animal Models:

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NDUFB11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDUFB11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDUFB11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDUFB11 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDUFB11
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NDUFB11:
    hsa-miR-526b hsa-miR-103a-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NDUFB11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFB11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NDUFB11
    Sirion Biotech Customized adenovirus for overexpression of NDUFB11

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NDUFB11 (see all 13)
    OriGene ORF clones in mouse, rat for NDUFB11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NDUFB11 (NM_001135998)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFB11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB11
    Sirion Biotech Customized lentivirus for stable overexpression of NDUFB11 
                         Customized lentivirus expression plasmids for stable overexpression of NDUFB11 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NDUFB11
    Search LifeMap BioReagents cell lines for NDUFB11
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDUFB11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Huntington's disease0.47
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Alzheimer's disease0.46
    Oxidative phosphorylation0.64
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for NDUFB11
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/6         Kegg Pathways  (Kegg details for NDUFB11) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFB11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFB11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/66 Interacting proteins for NDUFB11 (Q9NX142, 3 ENSP000002760624) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRELD2Q6UXH12, 3MINT-8263599 I2D: score=1 
    BAG6P463793I2D: score=1 
    ENSG00000096155P463793I2D: score=1 
    ENSG00000227761P463793I2D: score=1 
    ENSG00000228760P463793I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFB11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDUFB11 (NDUBB)

    8 HMDB Compounds for NDUFB11    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    Search CenterWatch for drugs/clinical trials and news about NDUFB11 / NDUBB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDUFB11 gene (2 alternative transcripts): 
    NM_001135998.2  NM_019056.6  

    Unigene Cluster for NDUFB11:

    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
    Hs.521969  [show with all ESTs]
    Unigene Representative Sequence: BQ278575
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377811(uc004dhc.3 uc004dhd.3) ENST00000276062

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDUFB11
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NDUFB11:
    hsa-miR-526b hsa-miR-103a-2*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NDUFB11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFB11
    Clone
    Products:
         
    OriGene clones in human, mouse for NDUFB11 (see all 13)
    OriGene ORF clones in mouse, rat for NDUFB11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NDUFB11 (NM_001135998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFB11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB11
    Sirion Biotech Customized lentivirus for stable overexpression of NDUFB11 
                         Customized lentivirus expression plasmids for stable overexpression of NDUFB11 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NDUFB11
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFB11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFB11
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFB11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFB11

    Additional mRNA sequence: 

    AF044213.1 AF134476.1 AF251063.1 AK000501.1 AY359056.1 BC010665.1 BC107805.1 CR457239.1 

    7 DOTS entries:

    DT.454683  DT.95208019  DT.100756555  DT.101984296  DT.100889292  DT.95076739  DT.121282105 

    24/276 AceView cDNA sequences (see all 276):

    BM721469 BM842065 BM841002 CB127595 F36916 BM665264 CA430861 AK000501 
    CA434634 BI712757 BU509402 BQ057397 AJ346376 AW007497 AI653431 BU730764 
    BU848622 CB125437 BC010665 BQ670209 BQ183319 BF594004 BP373543 BQ925073 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB11    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3
    SP1:                    -         
    SP2:                              


    ECgene alternative splicing isoforms for NDUFB11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDUFB11 expression in normal human tissues (normalized intensities)      NDUFB11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCCAACT
    NDUFB11 Expression
    About this image


    NDUFB11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             brain/midbrain   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See NDUFB11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDUFB11

    SOURCE GeneReport for Unigene cluster: Hs.521969

    UniProtKB/Swiss-Prot: NDUBB_HUMAN, Q9NX14
    Tissue specificity: Ubiquitous

        SABiosciences Custom PCR Arrays for NDUFB11
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NDUFB11
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFB11
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFB11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFB11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFB11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NDUFB11 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufb111 , 5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more1, 5 82.12(n)1
    77.48(a)1
      X (16.11 cM)5
    1041301  NM_019435.41  NP_062308.21 
     206153265 
    zebrafish
    (Danio rerio)
    Actinopterygii ndufb111 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 58.56(n)
    51.35(a)
      562219  NM_001044981.1  NP_001038446.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NP15.66
    NP15.6
    29(a)
    1 ↔ 1
    3R(14853074-14853737)


    ENSEMBL Gene Tree for NDUFB11 (if available)
    TreeFam Gene Tree for NDUFB11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDUFB11 gene

    NDUFB11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NDUFB11
    PGOHUM00000242424


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/21 SNPs in NDUFB11 are shown (see all 21)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1864537101,2
    --47001169(+) GGGAGA/GTGGAG 2 -- int10--------
    rs1499130481,2
    --47001515(+) CAGCAA/GTATAC 2 -- int10--------
    rs736302561,2
    C,F--47001611(+) ACTAGT/CGAGTC 2 -- int11Minor allele frequency- C:0.00WA 2
    rs2006559691,2
    --47001686(+) AAGGCA/GGTGCT 2 -- ut310--------
    rs1997267681,2
    --47001818(+) GCTTCA/GCGGCG 4 R syn10--------
    rs1912757871,2
    C--47001991(+) TCCCAC/TGCTCT 3 A syn1 int10--------
    rs2018861241,2
    --47002007(+) ACCCTA/GTGCAC 3 T I mis1 int10--------
    rs1826010591,2
    C--47002024(+) TCAGGC/GAGATA 4 L syn10--------
    rs105301,2
    C--47002096(+) ATGTTC/TCAGAC 4 * W stg1 ese36Minor allele frequency- T:0.00NA EA MN 440
    rs1864694641,2
    C--47002101(+) CCAGAC/TGTCCA 4 I V mis10--------

    HapMap Linkage Disequilibrium report for NDUFB11 (47001615 - 47004903 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NDUFB11: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFB11
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFB11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300403    OMIM disorders: --

    12 diseases for NDUFB11:    About MalaCards
    stiff-person syndrome    lewy body dementia    toxic encephalopathy    endometrial stromal sarcoma
    leber hereditary optic neuropathy    neuronitis    dementia    huntington's disease
    neuropathy    parkinson's disease    sarcoma    alzheimer's disease

    2 diseases from the University of Copenhagen DISEASES database for NDUFB11:
    Parkinson's disease     Lewy body dementia

    NDUFB11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for NDUFB11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDUFB11 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NDUFB11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and tissue expressional characterization of a full-length cDNA encoding human neuronal protein P17.3. (PubMed id 10544803)1, 2, 3 Cui Y.... Zhao S. (1999)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
    6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    7. Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits. (PubMed id 12381726)1, 3 Carroll J....Hirst J. (2002)
    8. The NDUFB11 gene is not a modifier in Leber hereditary optic neuropathy. (PubMed id 17292333)1, 9 Petruzzella V....Santorelli F.M. (2007)
    9. The mechanism of alternative splicing of the X-linked NDUFB11 gene of the respiratory chain complex I, impact of rotenone treatment in neuroblastoma cells. (PubMed id 23246602)1 Panelli D....Papa S. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54539 HGNC: 20372 AceView: NDUFB11 Ensembl:ENSG00000147123 euGenes: HUgn54539
    ECgene: NDUFB11 Kegg: 54539 H-InvDB: NDUFB11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDUFB11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDUFB11 gene:
    Search GeneIP for patents involving NDUFB11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NDUFB11  
     OriGene qPCR primer pairs and template standards for NDUFB11   OriGene Protein Over-expression Lysate for NDUFB11  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NDUFB11  
     OriGene qSTAR qPCR primer pairs in human, mouse for NDUFB11   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NDUFB11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NDUFB11   OriGene Custom Protein Services for NDUFB11  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFB11
     QIAGEN SeqTarget long-range PCR primers for resequencing NDUFB11
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFB11
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFB11
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFB11
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFB11
     GenScript Custom Purified and Recombinant Proteins Services for NDUFB11 GenScript cDNA clones with any tag delivered in your preferred vector for NDUFB11
     GenScript Custom Assay Services for NDUFB11 GenScript Custom Superior Antibodies Services for NDUFB11
     GenScript Custom overexpressing Cell Line Services for NDUFB11 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NDUFB11 promoter
     Search Chromatin IP Primers for NDUFB11
     RT2 qPCR Primer Assay in human, mouse, rat NDUFB11
     Search GNC Networks for NDUFB11
     SABiosciences Custom PCR Arrays for NDUFB11
     Search Tocris compounds for NDUFB11 (NDUBB)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NDUFB11 antibodies
     NDUFB11 proteins
     NDUFB11 lysates
     Antibodies for NDUFB11
     See all of Abcam's Antibodies, Kits and Proteins for NDUFB11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for NDUFB11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB11
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NDUFB11
     SwitchGear Promoter luciferase reporter plasmids for NDUFB11
     Search ThermoFisher Antibodies for NDUFB11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB11
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NDUFB11
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDUFB11
    Customized:
     lentivirus for stable overexpression of NDUFB11
     lentivirus expression plasmids for stable overexpression of NDUFB11
     adenovirus for overexpression of NDUFB11
     Search LSBio for Antibodies for NDUFB11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NDUFB11 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4