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Aliases for NDUFB11 Gene

Aliases for NDUFB11 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 11, 17.3kDa 2 3
  • NADH-Ubiquinone Oxidoreductase ESSS Subunit 3 4
  • Complex I NP17.3 Subunit 2 3
  • Neuronal Protein 17.3 3 4
  • Complex I-ESSS 3 4
  • CI-ESSS 3 4
  • NP17.3 3 4
  • P17.3 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 11, Mitochondrial 3
  • ESSS 3
  • Np15 3

External Ids for NDUFB11 Gene

Summaries for NDUFB11 Gene

Entrez Gene Summary for NDUFB11 Gene

  • NDUFB11 is a component of mitochondrial complex I. Complex I catalyzes the first step in the electron transport chain, the transfer of 2 electrons from NADH to ubiquinone, coupled to the translocation of 4 protons across the membrane (Carroll et al., 2002 [PubMed 12381726]).[supplied by OMIM, Feb 2009]

GeneCards Summary for NDUFB11 Gene

NDUFB11 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 11, 17.3kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism.

UniProtKB/Swiss-Prot for NDUFB11 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB11 Gene

Genomics for NDUFB11 Gene

Genomic Location for NDUFB11 Gene

Start:
47,142,216 bp from pter
End:
47,145,504 bp from pter
Size:
3,289 bases
Orientation:
Minus strand

Genomic View for NDUFB11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB11 Gene

Regulatory Elements for NDUFB11 Gene

Proteins for NDUFB11 Gene

  • Protein details for NDUFB11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX14-NDUBB_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
    Protein Accession:
    Q9NX14
    Secondary Accessions:
    • Q5JRR3
    • Q5JRR4
    • Q6IAB6
    • Q8WZ96
    • Q9BXX9

    Protein attributes for NDUFB11 Gene

    Size:
    153 amino acids
    Molecular mass:
    17317 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB11 Gene

Proteomics data for NDUFB11 Gene at MOPED

Post-translational modifications for NDUFB11 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys46

Other Protein References for NDUFB11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB11 Gene

Domains for NDUFB11 Gene

Gene Families for NDUFB11 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFB11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX14

UniProtKB/Swiss-Prot:

NDUBB_HUMAN
Family:
  • Belongs to the complex I NDUFB11 subunit family.:
    • Q9NX14
genes like me logo Genes that share domains with NDUFB11: view

Function for NDUFB11 Gene

Molecular function for NDUFB11 Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NDUFB11: view

miRNA for NDUFB11 Gene

miRTarBase miRNAs that target NDUFB11

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFB11 Gene

Localization for NDUFB11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB11 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB11 Gene COMPARTMENTS Subcellular localization image for NDUFB11 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
extracellular 2
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for NDUFB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I IDA 12611891
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDUFB11: view

Pathways for NDUFB11 Gene

genes like me logo Genes that share pathways with NDUFB11: view

Gene Ontology (GO) - Biological Process for NDUFB11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB11: view

Compounds for NDUFB11 Gene

(8) HMDB Compounds for NDUFB11 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9
genes like me logo Genes that share compounds with NDUFB11: view

Transcripts for NDUFB11 Gene

mRNA/cDNA for NDUFB11 Gene

Unigene Clusters for NDUFB11 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1: -
SP2:

Relevant External Links for NDUFB11 Gene

GeneLoc Exon Structure for
NDUFB11
ECgene alternative splicing isoforms for
NDUFB11

Expression for NDUFB11 Gene

mRNA expression in normal human tissues for NDUFB11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB11 Gene

SOURCE GeneReport for Unigene cluster for NDUFB11 Gene Hs.521969

mRNA Expression by UniProt/SwissProt for NDUFB11 Gene

Q9NX14-NDUBB_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with NDUFB11: view

No data available for mRNA differential expression in normal tissues for NDUFB11 Gene

Orthologs for NDUFB11 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB11 35
  • 99.56 (n)
  • 98.69 (a)
NDUFB11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB11 35
  • 89.54 (n)
  • 84.97 (a)
NDUFB11 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB11 35
  • 87.92 (n)
  • 86.96 (a)
NDUFB11 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700029P11Rik 36
  • 64 (a)
OneToMany
Ndufb11 35
  • 82.12 (n)
  • 77.48 (a)
Ndufb11 16
Ndufb11 36
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NDUFB11 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb11 35
  • 81.68 (n)
  • 78.81 (a)
zebrafish
(Danio rerio)
Actinopterygii ndufb11 35
  • 54.32 (n)
  • 46.67 (a)
ndufb11 36
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NP15.6 36
  • 26 (a)
OneToOne
Species with no ortholog for NDUFB11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB11 Gene

ENSEMBL:
Gene Tree for NDUFB11 (if available)
TreeFam:
Gene Tree for NDUFB11 (if available)

Paralogs for NDUFB11 Gene

Pseudogenes.org Pseudogenes for NDUFB11 Gene

genes like me logo Genes that share paralogs with NDUFB11: view

No data available for Paralogs for NDUFB11 Gene

Variants for NDUFB11 Gene

Sequence variations from dbSNP and Humsavar for NDUFB11 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs10530 -- 47,142,697(+) ATGTT(C/T)CAGAC stop-gained, reference
rs73630256 -- 47,142,212(+) ACTAG(C/T)GAGTC downstream-variant-500B
rs142555630 -- 47,143,203(+) TCTAT(A/G)TTTAC intron-variant
rs143960444 -- 47,142,350(+) CTGGG(A/G)TCGAA reference, synonymous-codon
rs144343841 -- 47,142,711(+) CAAAA(C/T)GGGGT missense, reference

Relevant External Links for NDUFB11 Gene

HapMap Linkage Disequilibrium report
NDUFB11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFB11 Gene

Disorders for NDUFB11 Gene

(2) University of Copenhagen DISEASES for NDUFB11 Gene

genes like me logo Genes that share disorders with NDUFB11: view

No data available for UniProtKB/Swiss-Prot for NDUFB11 Gene

Publications for NDUFB11 Gene

  1. Cloning and tissue expressional characterization of a full-length cDNA encoding human neuronal protein P17.3. (PMID: 10544803) Cui Y. … Zhao S. (Biochem. Genet. 1999) 2 3 4
  2. Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits. (PMID: 12381726) Carroll J. … Hirst J. (J. Biol. Chem. 2002) 2 3
  3. The NDUFB11 gene is not a modifier in Leber hereditary optic neuropathy. (PMID: 17292333) Petruzzella V. … Santorelli F.M. (Biochem. Biophys. Res. Commun. 2007) 3 23
  4. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for NDUFB11 Gene

Sources for NDUFB11 Gene

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