NDUFB10 Gene
protein-coding GIFtS: 51
GCID: GC16P002074
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NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 (22kD,...)
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Aliases
for NDUFB10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10, 22kDa1 2 | | NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10 (22kD, PDSW)1 | | PDSW1 2 | | Complex I PDSW Subunit2 | | Complex I-PDSW2 3 | | NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 102 | | CI-PDSW2 3 | | NADH Ubiquinone Oxidoreductase PDSW Subunit (RH 16p13.3)2 | | NADH-Ubiquinone Oxidoreductase PDSW Subunit2 3 | | |
Export aliases for NDUFB10 gene to outside databasesPrevious GC identifers: GC16P002026 GC16P001949 GC16P002014 GC16P001933 GC16P002023 GC16P002027 GC16P002030 GC16P002053 |
Summaries
for NDUFB10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NDUBA_HUMAN, O96000Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Wiki entry for NDUFB10
|
Genomic Views
for NDUFB10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDUFB10 gene promoter:
HEN1 NF-1/L NF-1 MAZR Pax-5 MyoD Nkx2-5 NF-kappaB1 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFB10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFB10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3NDUFB10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P002074: view genomic region
(about GC identifiers)
Start:
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2,009,509 bp from pter |
End:
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2,011,976 bp from pter |
Size:
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2,468 bases |
Orientation:
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plus strand |
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Proteins
for NDUFB10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NDUBA_HUMAN, O96000 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 Size: 172 amino acids; 20777 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix sideExplore the universe of human proteins at neXtProt for NDUFB10: NX_O96000
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O96000
NDUFB10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004539.1
ENSEMBL proteins: ENSP00000268668 ENSP00000445086 ENSP00000455348 ENSP00000457908 Reactome Protein details: O96000
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NDUFB10 for ontologies About GeneDecksing
NDUFB10 Antibody Products:
Assay Products for NDUFB10: |
Protein
Domains /
Families
for NDUFB10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NDUFB10 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O96000ProtoNet protein and cluster: O96000 UniProtKB/Swiss-Prot: NDUBA_HUMAN, O96000Similarity: Belongs to the complex I NDUFB10 subunit family |
Function
for NDUFB10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NDUBA_HUMAN, O96000Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone Genatlas biochemistry entry for NDUFB10:NADH ubiquinone oxidoreductase (Q reductase),22kDa,component beta 10,hydrophobic fraction of the complex Imulti-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFB10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFB10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for NDUFB10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB10 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
NDUFB10 for ontologies About GeneDecksing
|
Pathways & Interactions
for NDUFB10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NDUFB10
4 
Reactome Pathways for NDUFB10
5 
Kegg Pathways (Kegg details for NDUFB10):
NDUFB10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFB10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/64 Interacting proteins for NDUFB10 (O960003 ENSP000002686684) via UniProtKB, MINT, STRING, and/or I2D (see all 64)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
NAS | 9878551 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
NDUFB10 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDUFB10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NDUFB10
8 HMDB Compounds for NDUFB10 About this table
1 DrugBank Compound for NDUFB10 About this table
Search CenterWatch for drugs/clinical trials and news about NDUFB10 / NDUBA
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Transcripts
for NDUFB10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NDUFB10 gene: NM_004548.2 Unigene Cluster for NDUFB10: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa Hs.513266 [show with all ESTs]Unigene Representative Sequence: BQ2784645 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000268668(uc002cni.2) ENST00000543683(uc002cnj.2) ENST00000565031
ENST00000569148 ENST00000570172
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFB10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFB10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NDUFB10 (NM_004548) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDUFB10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB10 |
Additional cDNA sequence: AF044954.1 AF067169.1 AF088991.1 AK291876.1 AK311744.1 BC005829.2 BC007509.2 13 DOTS entries: DT.99982850 DT.97859587 DT.417504 DT.100035315 DT.120702516 DT.95278230 DT.100747916 DT.95278227 DT.120702603 DT.95278228 DT.120702621 DT.121638967 DT.120702583 24/252 AceView cDNA sequences (see all 252): F25963 BM663404 BC005829 BU838289 BU732992 BM663295 BQ073687 BU509665 BE869285 BM707909 BE311640 BQ949294 F34362 BM664377 BM696092 BU727380 BM760633 BM549529 AW024493 BQ929618 F24311 BU730837 BG757972 BM708541
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB10 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 |
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| SP1: | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NDUFB10
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Expression
for NDUFB10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDUFB10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGCAGAGGC
About this image
See NDUFB10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDUFB10
SOURCE GeneReport for Unigene cluster: Hs.513266
SABiosciences Expression via Pathway-Focused PCR Array including NDUFB10: | Mitochondrial Energy Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFB10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFB10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFB10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFB10 |
Orthologs
for NDUFB10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NDUFB10 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for NDUFB10 (if available)
TreeFam Gene Tree for NDUFB10 (if available) |
Paralogs
for NDUFB10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NDUFB10 gene
NDUFB10 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for NDUFB10
PGOHUM00000246796 PGOHUM00000262494
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Genomic Variants
for NDUFB10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NDUFB10 (2009509 - 2011976 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NDUFB10
3 CNVs: 5329 29656 4917 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFB10 |
|
Disorders
/ Diseases
for NDUFB10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDUFB10 for disorders About GeneDecksing
OMIM gene information: 603843
OMIM disorders: --
2  diseases for NDUFB10: About MalaCardshuntington's disease parkinson's disease
Human Genome Epidemiology (HuGE) Navigator: NDUFB10 (3 documents)
Export disorders for NDUFB10 gene to outside databases
|
Publications
for NDUFB10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NDUFB10 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with NDUFB10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2, 3 Loeffen J.L....Smeitink J.A. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
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External Searches for NDUFB10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDUFB10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFB10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFB10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NDUFB10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NDUFB10 gene:
Search GeneIP for patents involving NDUFB10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDUFB10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for NDUFB10 | | OriGene Custom Protein Services for NDUFB10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFB10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFB10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFB10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFB10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFB10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFB10 |
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| | | | Search Tocris compounds for NDUFB10 |
| |  |  |  |  | | | | |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB10 |
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