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Aliases for NDUFB10 Gene

Aliases for NDUFB10 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10, 22kDa 2 3
  • NADH-Ubiquinone Oxidoreductase PDSW Subunit 3 4
  • Complex I PDSW Subunit 2 3
  • Complex I-PDSW 3 4
  • CI-PDSW 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10 (22kD, PDSW) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 10 3
  • NADH Ubiquinone Oxidoreductase PDSW Subunit (RH 16p13.3) 3
  • PDSW 3

External Ids for NDUFB10 Gene

Previous GeneCards Identifiers for NDUFB10 Gene

  • GC16P002026
  • GC16P001949
  • GC16P002014
  • GC16P001933
  • GC16P002023
  • GC16P002027
  • GC16P002030
  • GC16P002053
  • GC16P002074
  • GC16P002091
  • GC16P002112

Summaries for NDUFB10 Gene

GeneCards Summary for NDUFB10 Gene

NDUFB10 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10, 22kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB10 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB10 Gene

Genomics for NDUFB10 Gene

Regulatory Elements for NDUFB10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDUFB10 Gene

Start:
1,959,508 bp from pter
End:
1,961,975 bp from pter
Size:
2,468 bases
Orientation:
Plus strand

Genomic View for NDUFB10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB10 Gene

Proteins for NDUFB10 Gene

  • Protein details for NDUFB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96000-NDUBA_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
    Protein Accession:
    O96000
    Secondary Accessions:
    • Q96II6

    Protein attributes for NDUFB10 Gene

    Size:
    172 amino acids
    Molecular mass:
    20777 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB10 Gene

Proteomics data for NDUFB10 Gene at MOPED

Post-translational modifications for NDUFB10 Gene

  • Ubiquitination at Lys91, Lys121, and Lys131
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFB10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB10 Gene

Domains for NDUFB10 Gene

Gene Families for NDUFB10 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O96000

UniProtKB/Swiss-Prot:

NDUBA_HUMAN :
  • O96000
Family:
  • Belongs to the complex I NDUFB10 subunit family.
genes like me logo Genes that share domains with NDUFB10: view

Function for NDUFB10 Gene

Molecular function for NDUFB10 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),22kDa,component beta 10,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14557246
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB10: view

Animal Model Products

CRISPR Products

miRNA for NDUFB10 Gene

miRTarBase miRNAs that target NDUFB10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFB10 Gene

Localization for NDUFB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB10 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB10 Gene COMPARTMENTS Subcellular localization image for NDUFB10 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NDUFB10: view

Pathways for NDUFB10 Gene

genes like me logo Genes that share pathways with NDUFB10: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat

Gene Ontology (GO) - Biological Process for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB10: view

Compounds for NDUFB10 Gene

(8) HMDB Compounds for NDUFB10 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB10 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB10: view

Transcripts for NDUFB10 Gene

Unigene Clusters for NDUFB10 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2: -
SP3:

Relevant External Links for NDUFB10 Gene

GeneLoc Exon Structure for
NDUFB10
ECgene alternative splicing isoforms for
NDUFB10

Expression for NDUFB10 Gene

mRNA expression in normal human tissues for NDUFB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFB10 Gene

This gene is overexpressed in Heart - Left Ventricle (4.7) and Muscle - Skeletal (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB10 Gene

SOURCE GeneReport for Unigene cluster for NDUFB10 Gene Hs.513266

genes like me logo Genes that share expressions with NDUFB10: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NDUFB10 Gene

Orthologs for NDUFB10 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB10 35
  • 99.22 (n)
  • 98.84 (a)
NDUFB10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB10 35
  • 86.5 (n)
  • 81.65 (a)
NDUFB10 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFB10 35
  • 85.65 (n)
  • 81.65 (a)
NDUFB10 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufb10 35
  • 80.54 (n)
  • 82.61 (a)
Ndufb10 16
Ndufb10 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB10 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB10 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufb10 35
  • 82.4 (n)
  • 82.61 (a)
chicken
(Gallus gallus)
Aves NDUFB10 35
  • 67.29 (n)
  • 58.12 (a)
NDUFB10 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB10 36
  • 50 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21405 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb10 35
  • 66.05 (n)
  • 64.6 (a)
Str.10643 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8497 35
zebrafish
(Danio rerio)
Actinopterygii ndufb10 35
  • 65.21 (n)
  • 58.12 (a)
ndufb10 36
  • 54 (a)
OneToOne
zgc73147 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007780 35
  • 51.72 (n)
  • 36.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pdsw 35
  • 51.08 (n)
  • 31.65 (a)
Pdsw 36
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F59C6.5 35
  • 43.97 (n)
  • 36.17 (a)
F59C6.5 36
  • 20 (a)
OneToOne
Species with no ortholog for NDUFB10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFB10 Gene

ENSEMBL:
Gene Tree for NDUFB10 (if available)
TreeFam:
Gene Tree for NDUFB10 (if available)

Paralogs for NDUFB10 Gene

Pseudogenes.org Pseudogenes for NDUFB10 Gene

genes like me logo Genes that share paralogs with NDUFB10: view

No data available for Paralogs for NDUFB10 Gene

Variants for NDUFB10 Gene

Sequence variations from dbSNP and Humsavar for NDUFB10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs338785 -- 1,957,724(+) ccaca(A/C/G)tgtgg upstream-variant-2KB
rs338786 -- 1,957,885(+) caaag(C/T)ttctc upstream-variant-2KB
rs338787 -- 1,958,094(+) ataaa(A/G)gttct upstream-variant-2KB
rs338788 -- 1,959,851(+) CGTCT(C/G)CCTGA intron-variant
rs338789 -- 1,959,869(+) CCCCG(C/G)TGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB10 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
nsv519366 CNV Loss 19592680
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
nsv833120 CNV Loss 17160897
nsv905048 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2547n71 CNV Loss 21882294
dgv2548n71 CNV Gain 21882294
dgv2549n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv905061 CNV Loss 21882294
dgv2551n71 CNV Loss 21882294
nsv471070 CNV Gain 18288195
nsv905070 CNV Gain+Loss 21882294
dgv2552n71 CNV Gain+Loss 21882294

Relevant External Links for NDUFB10 Gene

HapMap Linkage Disequilibrium report
NDUFB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB10 Gene

Disorders for NDUFB10 Gene

Relevant External Links for NDUFB10

Genetic Association Database (GAD)
NDUFB10
Human Genome Epidemiology (HuGE) Navigator
NDUFB10
genes like me logo Genes that share disorders with NDUFB10: view

No data available for UniProtKB/Swiss-Prot for NDUFB10 Gene

Publications for NDUFB10 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

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