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Aliases for NDUFB10 Gene

Aliases for NDUFB10 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B10 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10, 22kDa 2 3
  • NADH-Ubiquinone Oxidoreductase PDSW Subunit 3 4
  • Complex I PDSW Subunit 2 3
  • Complex I-PDSW 3 4
  • CI-PDSW 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10 (22kD, PDSW) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 10 3
  • NADH Ubiquinone Oxidoreductase PDSW Subunit (RH 16p13.3) 3
  • PDSW 3

External Ids for NDUFB10 Gene

Previous GeneCards Identifiers for NDUFB10 Gene

  • GC16P002026
  • GC16P001949
  • GC16P002014
  • GC16P001933
  • GC16P002023
  • GC16P002027
  • GC16P002030
  • GC16P002053
  • GC16P002074
  • GC16P002091
  • GC16P002112
  • GC16P001976
  • GC16P001983
  • GC16P001990
  • GC16P001996

Summaries for NDUFB10 Gene

GeneCards Summary for NDUFB10 Gene

NDUFB10 (NADH:Ubiquinone Oxidoreductase Subunit B10) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB10 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB10 Gene

Genomics for NDUFB10 Gene

Regulatory Elements for NDUFB10 Gene

Enhancers for NDUFB10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F001863 0.7 ENCODE 12.2 -95.6 -95614 0.2 CTCF ZNF654 KLF4 REST RAD21 RFX5 ZNF121 ZFHX2 GLIS1 KLF9 HS3ST6 MEIOB MSRB1 RPL3L NDUFB10 SYNGR3 GC16M001851 LOC102723890
GH16F001978 0.7 ENCODE 11.9 +20.1 20075 1.8 CTCF GTF2F1 MAX ZIC2 YY1 E2F1 HIC1 ZFHX2 POLR2A SCRT2 ENSG00000255513 NDUFB10 RPL3L MSRB1 GFER TBL3
GH16F001900 0.7 ENCODE 11.6 -59.2 -59184 0.2 CTCF ZNF687 PKNOX1 RNF2 SAP130 SIN3A MNT RAD21 ZNF592 ZNF121 FAHD1 HS3ST6 MSRB1 NDUFB10 RPL3L PIR49138
GH16F001895 0.6 ENCODE 12.3 -63.4 -63400 0.5 ZBTB7A ZNF217 ARID1B ZFHX2 GATA3 NCOR1 KDM1A TRIM24 EGR2 FAHD1 HS3ST6 MSRB1 NDUFB10 RPL3L IGFALS HAGH PIR49138
GH16F001901 0.6 ENCODE 11.6 -59.0 -58954 0.2 ZNF687 RNF2 SAP130 MNT ZNF592 FAHD1 HS3ST6 MSRB1 NDUFB10 RPL3L PIR49138
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NDUFB10 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFB10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001798982 392 1401 HDGF ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for NDUFB10 Gene

Chromosome:
16
Start:
1,959,508 bp from pter
End:
1,961,975 bp from pter
Size:
2,468 bases
Orientation:
Plus strand

Genomic View for NDUFB10 Gene

Genes around NDUFB10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB10 Gene

Proteins for NDUFB10 Gene

  • Protein details for NDUFB10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O96000-NDUBA_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10
    Protein Accession:
    O96000
    Secondary Accessions:
    • Q96II6

    Protein attributes for NDUFB10 Gene

    Size:
    172 amino acids
    Molecular mass:
    20777 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

    Alternative splice isoforms for NDUFB10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB10 Gene

Post-translational modifications for NDUFB10 Gene

  • Ubiquitination at Lys 91, Lys 121, and Lys 131
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFB10 Gene

Antibody Products

No data available for DME Specific Peptides for NDUFB10 Gene

Domains & Families for NDUFB10 Gene

Protein Domains for NDUFB10 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O96000

UniProtKB/Swiss-Prot:

NDUBA_HUMAN :
  • Belongs to the complex I NDUFB10 subunit family.
Family:
  • Belongs to the complex I NDUFB10 subunit family.
genes like me logo Genes that share domains with NDUFB10: view

Function for NDUFB10 Gene

Molecular function for NDUFB10 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),22kDa,component beta 10,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14557246
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB10: view
genes like me logo Genes that share phenotypes with NDUFB10: view

Animal Model Products

miRNA for NDUFB10 Gene

miRTarBase miRNAs that target NDUFB10

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB10 Gene

Localization for NDUFB10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB10 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFB10 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane IEA,TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NDUFB10: view

Pathways & Interactions for NDUFB10 Gene

genes like me logo Genes that share pathways with NDUFB10: view

Gene Ontology (GO) - Biological Process for NDUFB10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFB10: view

No data available for SIGNOR curated interactions for NDUFB10 Gene

Drugs & Compounds for NDUFB10 Gene

(1) Drugs for NDUFB10 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra Target 0
genes like me logo Genes that share compounds with NDUFB10: view

Transcripts for NDUFB10 Gene

Unigene Clusters for NDUFB10 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB10 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
SP1: -
SP2: -
SP3:

Relevant External Links for NDUFB10 Gene

GeneLoc Exon Structure for
NDUFB10
ECgene alternative splicing isoforms for
NDUFB10

Expression for NDUFB10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NDUFB10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFB10 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.7) and Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for NDUFB10 Gene

This gene is overexpressed in Nasal epithelium (29.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFB10 Gene



Protein tissue co-expression partners for NDUFB10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFB10 Gene:

NDUFB10

SOURCE GeneReport for Unigene cluster for NDUFB10 Gene:

Hs.513266
genes like me logo Genes that share expression patterns with NDUFB10: view

No data available for mRNA Expression by UniProt/SwissProt for NDUFB10 Gene

Orthologs for NDUFB10 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFB10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB10 34 35
  • 99.22 (n)
cow
(Bos Taurus)
Mammalia NDUFB10 34 35
  • 86.5 (n)
dog
(Canis familiaris)
Mammalia NDUFB10 34 35
  • 85.65 (n)
rat
(Rattus norvegicus)
Mammalia Ndufb10 34
  • 82.4 (n)
mouse
(Mus musculus)
Mammalia Ndufb10 34 16 35
  • 80.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB10 35
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB10 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFB10 34 35
  • 67.29 (n)
lizard
(Anolis carolinensis)
Reptilia NDUFB10 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufb10 34
  • 66.05 (n)
Str.10643 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21405 34
zebrafish
(Danio rerio)
Actinopterygii ndufb10 34 35
  • 65.21 (n)
zgc73147 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8497 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007780 34
  • 51.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta Pdsw 34 35
  • 51.08 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_F59C6.5 34
  • 43.97 (n)
F59C6.5 35
  • 20 (a)
OneToOne
Species where no ortholog for NDUFB10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFB10 Gene

ENSEMBL:
Gene Tree for NDUFB10 (if available)
TreeFam:
Gene Tree for NDUFB10 (if available)

Paralogs for NDUFB10 Gene

Pseudogenes.org Pseudogenes for NDUFB10 Gene

genes like me logo Genes that share paralogs with NDUFB10: view

No data available for Paralogs for NDUFB10 Gene

Variants for NDUFB10 Gene

Sequence variations from dbSNP and Humsavar for NDUFB10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs111564627 -- 1,961,495(+) CCACC(A/T)GCAAA splice-acceptor-variant
rs111732546 -- 1,959,870(+) CCCGC(G/T)GCACC intron-variant
rs112242130 -- 1,961,662(+) CAACC(C/T)CCCAC intron-variant, downstream-variant-500B
rs11248903 -- 1,957,726(+) acact(A/G)tggaa upstream-variant-2KB
rs112654116 -- 1,961,073(+) CCTCC(A/C)AAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB10 Gene

Variant ID Type Subtype PubMed ID
nsv984249 CNV duplication 23825009
nsv952901 CNV deletion 24416366
nsv833120 CNV loss 17160897
nsv571179 CNV loss 21841781
nsv571178 CNV loss 21841781
nsv519366 CNV loss 19592680
nsv471070 CNV gain 18288195
nsv1160329 CNV deletion 26073780
esv2422427 CNV duplication 17116639
dgv4858n54 CNV loss 21841781

Variation tolerance for NDUFB10 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFB10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFB10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB10 Gene

Disorders for NDUFB10 Gene

Relevant External Links for NDUFB10

Genetic Association Database (GAD)
NDUFB10
Human Genome Epidemiology (HuGE) Navigator
NDUFB10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFB10

No disorders were found for NDUFB10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFB10 Gene

Publications for NDUFB10 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 46 64
  4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for NDUFB10 Gene

Sources for NDUFB10 Gene

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