Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDUFB10 Gene

protein-coding   GIFtS: 57
GCID: GC16P002091

NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10, 22kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 (22kD,...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10, 22kDa1 2     NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 10 (22kD, PDSW)1
Complex I PDSW Subunit1 2     PDSW2
Complex I-PDSW2 3     NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 102
CI-PDSW2 3     NADH Ubiquinone Oxidoreductase PDSW Subunit (RH 16p13.3)2
NADH-Ubiquinone Oxidoreductase PDSW Subunit2 3     

External Ids:    HGNC: 76961   Entrez Gene: 47162   Ensembl: ENSG000001409907   OMIM: 6038435   UniProtKB: O960003   

Export aliases for NDUFB10 gene to outside databases

Previous GC identifers: GC16P002026 GC16P001949 GC16P002014 GC16P001933 GC16P002023 GC16P002027 GC16P002030 GC16P002053 GC16P002074


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NDUFB10 Gene: 
NDUFB10 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa) is a protein-coding gene. Diseases associated with NDUFB10 include huntington's disease, and parkinson's disease, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include protein binding and NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NDUBA_HUMAN, O96000
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDUFB10 gene promoter:
         HEN1   NF-1/L   NF-1   MAZR   Pax-5   MyoD   Nkx2-5   NF-kappaB1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFB10 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDUFB10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFB10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

NDUFB10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFB10 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P002091:  view genomic region     (about GC identifiers)

Start:
2,009,509 bp from pter      End:
2,011,976 bp from pter
Size:
2,468 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDUBA_HUMAN, O96000 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10  
Size: 172 amino acids; 20777 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side

Explore the universe of human proteins at neXtProt for NDUFB10: NX_O96000

Explore proteomics data for NDUFB10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O96000

  • NDUFB10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDUFB10 Protein Expression
    REFSEQ proteins: NP_004539.1  
    ENSEMBL proteins: 
     ENSP00000268668   ENSP00000445086   ENSP00000455348   ENSP00000457908  
    Reactome Protein details: O96000
    Human Recombinant Protein Products for NDUFB10: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NDUFB10
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NDUFB10
    GenScript Custom Purified and Recombinant Proteins Services for NDUFB10
    Novus Biologicals NDUFB10 Proteins
    Novus Biologicals NDUFB10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551

    NDUFB10 for ontologies           About GeneDecksing



    NDUFB10 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NDUFB10
    OriGene Custom Antibody Services for NDUFB10
    GenScript Custom Superior Antibodies Services for NDUFB10
    Novus Biologicals NDUFB10 Antibodies
    Abcam antibodies for NDUFB10
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for NDUFB10
    LSBio Antibodies in human, mouse, rat for NDUFB10 

    Assay Products for NDUFB10: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NDUFB10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NDUFB10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comI: Mitochondrial respiratory chain complex / Complex I

    1 InterPro protein domain:
     IPR019377 NADH_UbQ_OxRdtase_su10

    Graphical View of Domain Structure for InterPro Entry O96000

    ProtoNet protein and cluster: O96000

    UniProtKB/Swiss-Prot: NDUBA_HUMAN, O96000
    Similarity: Belongs to the complex I NDUFB10 subunit family


    NDUFB10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUBA_HUMAN, O96000
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Genatlas biochemistry entry for NDUFB10:
    NADH ubiquinone oxidoreductase (Q reductase),22kDa,component beta 10,hydrophobic fraction of the complex I
    multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14557246
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    NDUFB10 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NDUFB10 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDUFB10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDUFB10 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDUFB10 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDUFB10
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NDUFB10:
    hsa-miR-205*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NDUFB10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFB10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NDUFB10
    Sirion Biotech Customized adenovirus for overexpression of NDUFB10

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NDUFB10 (see all 8)
    OriGene ORF clones in mouse, rat for NDUFB10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDUFB10 (NM_004548)
    Sino Biological Human cDNA Clone for NDUFB10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB10
    Sirion Biotech Customized lentivirus for stable overexpression of NDUFB10 
                         Customized lentivirus expression plasmids for stable overexpression of NDUFB10 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NDUFB10
    Search LifeMap BioReagents cell lines for NDUFB10
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB10


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDUFB10 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.47
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Alzheimer's disease0.46
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFB10
        Electron Transport Chain
    Oxidative phosphorylation


    4        Reactome Pathways for NDUFB10
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/6         Kegg Pathways  (Kegg details for NDUFB10) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFB10 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFB10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for NDUFB10 (O960003 ENSP000002686684) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    HTR2AP282233, ENSP000003679594I2D: score=1 STRING: ENSP00000367959
    TSC1Q925743, ENSP000002985524I2D: score=2 STRING: ENSP00000298552
    UBE2DNLQ8IWF73I2D: score=1 
    NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFB10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDUFB10 (NDUBA)

    8 HMDB Compounds for NDUFB10    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFB10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about NDUFB10 / NDUBA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDUFB10 gene: 
    NM_004548.2  

    Unigene Cluster for NDUFB10:

    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa
    Hs.513266  [show with all ESTs]
    Unigene Representative Sequence: BQ278464
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268668(uc002cni.2) ENST00000543683(uc002cnj.2) ENST00000565031
    ENST00000569148 ENST00000570172

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDUFB10
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NDUFB10:
    hsa-miR-205*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NDUFB10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFB10
    Clone
    Products:
         
    OriGene clones in human, mouse for NDUFB10 (see all 8)
    OriGene ORF clones in mouse, rat for NDUFB10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDUFB10 (NM_004548)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFB10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB10
    Sirion Biotech Customized lentivirus for stable overexpression of NDUFB10 
                         Customized lentivirus expression plasmids for stable overexpression of NDUFB10 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NDUFB10
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFB10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFB10
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFB10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFB10

    Additional mRNA sequence: 

    AF044954.1 AF067169.1 AF088991.1 AK291876.1 AK311744.1 BC005829.2 BC007509.2 

    13 DOTS entries:

    DT.99982850  DT.97859587  DT.417504  DT.100035315  DT.120702516  DT.95278230  DT.100747916  DT.95278227 
    DT.120702603  DT.95278228  DT.120702621  DT.121638967  DT.120702583 

    24/252 AceView cDNA sequences (see all 252):

    BQ073687 BU732992 CD366977 BM541565 BF724546 BG757972 BC007509 BU730837 
    BM549529 BE391452 BC005829 BM663295 BM840197 BU838289 BQ421745 F25963 
    BM459153 BM664377 F34362 BQ929618 AW024493 BM696092 BQ949294 BM707909 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB10    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4
    SP1:                                -         
    SP2:                                -         
    SP3:                                          


    ECgene alternative splicing isoforms for NDUFB10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDUFB10 expression in normal human tissues (normalized intensities)      NDUFB10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGCAGAGGC
    NDUFB10 Expression
    About this image


    NDUFB10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
             skeleton/cranium   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Eye (Sensory Organs)
             Retina
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   

    See NDUFB10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDUFB10

    SOURCE GeneReport for Unigene cluster: Hs.513266
        SABiosciences Expression via Pathway-Focused PCR Array including NDUFB10: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NDUFB10
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFB10
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFB10
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFB10
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFB10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NDUFB10 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufb101 , 5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more1, 5 80(n)1
    81.76(a)1
      17 (12.51 cM)5
    683421  NM_026684.21  NP_080960.11 
     247220605 
    chicken
    (Gallus gallus)
    Aves NDUFB101 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 66.47(n)
    57.14(a)
      416543  XM_414844.3  XP_414844.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFB106
    Uncharacterized protein
    50(a)
    1 ↔ 1
    GL344276.1(97714-101490)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.214052 Xenopus laevis transcribed sequence with weak similarity more 76.77(n)    AW643467.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc731472 hypothetical protein MGC73147 73.27(n)   393703  BC059507.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pdsw1 CG8844-PA 51.16(n)
    31.25(a)
      44228  NM_143715.2  NP_651972.1 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_F59C6.51 Protein F59C6.5 43.66(n)
    35.92(a)
      172933  NM_060351.3  NP_492752.1 


    ENSEMBL Gene Tree for NDUFB10 (if available)
    TreeFam Gene Tree for NDUFB10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDUFB10 gene

    NDUFB10 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NDUFB10
    PGOHUM00000246796 PGOHUM00000262494


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/166 SNPs in NDUFB10 are shown (see all 166)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1484837181,2
    --2007552(+) TAAGGC/TGCCGC 1 -- us2k10--------
    rs1998303291,2
    C--2007554(+) AGGCG-/CCGCGCG 1 -- us2k10--------
    rs116412271,2
    C,F,H--2007560(+) cgcgcG/Atctgg 1 -- us2k1 tfbs38Minor allele frequency- A:0.36NA CSA WA EA 368
    rs1426543781,2
    --2007567(+) CTGGAA/GTTGTT 1 -- us2k10--------
    rs1509363331,2
    --2007578(+) CATCCC/TGCCAG 1 -- us2k10--------
    rs1394763101,2
    --2007603(+) CACTGC/GCTTCA 1 -- us2k10--------
    rs1149352451,2
    C,F--2007607(+) GGCTTC/TAGGAG 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1441885101,2
    C--2007623(+) CTGCAA/GATCTT 1 -- us2k10--------
    rs1855072641,2
    --2007665(+) TGTGAC/TCCCAA 1 -- us2k10--------
    rs1478093731,2
    --2007719(+) AAGCTC/TCCACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NDUFB10 (2009509 - 2011976 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for NDUFB10 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    dgv2545n71CNV Loss21882294
    dgv2546n71CNV Loss21882294
    nsv905048CNV Loss21882294
    dgv2551n71CNV Loss21882294
    dgv2540n71CNV Loss21882294
    nsv905061CNV Loss21882294
    dgv2547n71CNV Loss21882294
    nsv833120CNV Loss17160897
    nsv519366CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFB10
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFB10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603843    OMIM disorders: --

    3 diseases for NDUFB10:    About MalaCards
    huntington's disease    parkinson's disease    alzheimer's disease


    NDUFB10 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NDUFB10
    Human Genome Epidemiology (HuGE) Navigator: NDUFB10 (3 documents)

    Export disorders for NDUFB10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDUFB10 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with NDUFB10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2, 3 Loeffen J.L....Smeitink J.A. (1998)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    4. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    8. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (1998)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4716 HGNC: 7696 AceView: NDUFB10 Ensembl:ENSG00000140990 euGenes: HUgn4716
    ECgene: NDUFB10 Kegg: 4716 H-InvDB: NDUFB10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDUFB10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDUFB10 gene:
    Search GeneIP for patents involving NDUFB10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NDUFB10   OriGene RNAi products in human, mouse, rat for NDUFB10  
     OriGene qPCR primer pairs and template standards for NDUFB10   OriGene Protein Over-expression Lysate for NDUFB10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NDUFB10  
     OriGene qSTAR qPCR primer pairs in human, mouse for NDUFB10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NDUFB10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NDUFB10   OriGene Custom Protein Services for NDUFB10  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFB10
     QIAGEN SeqTarget long-range PCR primers for resequencing NDUFB10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFB10
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFB10
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFB10
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFB10
     GenScript Custom Purified and Recombinant Proteins Services for NDUFB10 GenScript cDNA clones with any tag delivered in your preferred vector for NDUFB10
     GenScript Custom Assay Services for NDUFB10 GenScript Custom Superior Antibodies Services for NDUFB10
     GenScript Custom overexpressing Cell Line Services for NDUFB10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NDUFB10 promoter
     Search Chromatin IP Primers for NDUFB10
     RT2 qPCR Primer Assay in human, mouse, rat NDUFB10
     Search GNC Networks for NDUFB10
     SABiosciences PCR Arrays including human, mouse, rat NDUFB10
     Search Tocris compounds for NDUFB10 (NDUBA)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for NDUFB10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NDUFB10 antibodies
     NDUFB10 proteins
     NDUFB10 lysates
     Antibodies for NDUFB10
     See all of Abcam's Antibodies, Kits and Proteins for NDUFB10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for NDUFB10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB10
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NDUFB10
     SwitchGear Promoter luciferase reporter plasmids for NDUFB10
     ThermoFisher Antibody for NDUFB10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB10
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NDUFB10
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDUFB10
    Customized:
     lentivirus for stable overexpression of NDUFB10
     lentivirus expression plasmids for stable overexpression of NDUFB10
     adenovirus for overexpression of NDUFB10
     LSBio Antibodies in human, mouse, rat for NDUFB10
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NDUFB10 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4