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Aliases for NDUFB1 Gene

Aliases for NDUFB1 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 1, 7kDa 2 3
  • NADH-Ubiquinone Oxidoreductase MNLL Subunit 3 4
  • Complex I MNLL Subunit 2 3
  • Complex I-MNLL 3 4
  • CI-MNLL 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 1 (7kD, MNLL) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 1 3
  • CI-SGDH 3
  • MNLL 3

External Ids for NDUFB1 Gene

Previous GeneCards Identifiers for NDUFB1 Gene

  • GC14M090088
  • GC14M086398
  • GC14M090572
  • GC14M091652
  • GC14M092582
  • GC14M072763

Summaries for NDUFB1 Gene

GeneCards Summary for NDUFB1 Gene

NDUFB1 (NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 1, 7kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFB1 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB1 Gene

Genomics for NDUFB1 Gene

Regulatory Elements for NDUFB1 Gene

Transcription factor binding sites by QIAGEN in the NDUFB1 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDUFB1 Gene

Start:
92,116,122 bp from pter
End:
92,121,917 bp from pter
Size:
5,796 bases
Orientation:
Minus strand

Genomic View for NDUFB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB1 Gene

Proteins for NDUFB1 Gene

  • Protein details for NDUFB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75438-NDUB1_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
    Protein Accession:
    O75438
    Secondary Accessions:
    • A0AV68

    Protein attributes for NDUFB1 Gene

    Size:
    58 amino acids
    Molecular mass:
    6961 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.
    SequenceCaution:
    • Sequence=AAD42054.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NDUFB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB1 Gene

Proteomics data for NDUFB1 Gene at MOPED

Post-translational modifications for NDUFB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFB1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFB1 Gene

Domains for NDUFB1 Gene

Gene Families for NDUFB1 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFB1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFB1 Gene

Graphical View of Domain Structure for InterPro Entry

O75438

UniProtKB/Swiss-Prot:

NDUB1_HUMAN :
  • O75438
Family:
  • Belongs to the complex I NDUFB1 subunit family.
genes like me logo Genes that share domains with NDUFB1: view

Function for NDUFB1 Gene

Molecular function for NDUFB1 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),7kDa,component beta 1,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003954 NADH dehydrogenase activity --
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFB1: view

Phenotypes for NDUFB1 Gene

GenomeRNAi human phenotypes for NDUFB1:
genes like me logo Genes that share phenotypes with NDUFB1: view

Animal Model Products

CRISPR Products

miRNA for NDUFB1 Gene

miRTarBase miRNAs that target NDUFB1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFB1 Gene

Localization for NDUFB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB1 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB1 Gene COMPARTMENTS Subcellular localization image for NDUFB1 gene
Compartment Confidence
mitochondrion 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NDUFB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NDUFB1: view

Pathways for NDUFB1 Gene

genes like me logo Genes that share pathways with NDUFB1: view

Interacting Proteins for NDUFB1 Gene

Gene Ontology (GO) - Biological Process for NDUFB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFB1: view

Compounds for NDUFB1 Gene

(8) HMDB Compounds for NDUFB1 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFB1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFB1: view

Transcripts for NDUFB1 Gene

Unigene Clusters for NDUFB1 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB1 Gene

No ASD Table

Relevant External Links for NDUFB1 Gene

GeneLoc Exon Structure for
NDUFB1
ECgene alternative splicing isoforms for
NDUFB1

Expression for NDUFB1 Gene

mRNA expression in normal human tissues for NDUFB1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB1 Gene

SOURCE GeneReport for Unigene cluster for NDUFB1 Gene Hs.183435

genes like me logo Genes that share expressions with NDUFB1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFB1 Gene

Orthologs for NDUFB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFB1 35
  • 99.68 (n)
  • 100 (a)
NDUFB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFB1 35
  • 89.66 (n)
  • 82.76 (a)
NDUFB1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102156783 35
  • 80.18 (n)
  • 71.62 (a)
mouse
(Mus musculus)
Mammalia LOC102631912 35
  • 83.04 (n)
  • 75.44 (a)
oppossum
(Monodelphis domestica)
Mammalia NDUFB1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB1 36
  • 20 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFB1 35
  • 70.11 (n)
  • 75.86 (a)
NDUFB1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB1 36
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6643 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3020 35
zebrafish
(Danio rerio)
Actinopterygii NDUFB1 36
  • 64 (a)
OneToOne
Species with no ortholog for NDUFB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB1 Gene

ENSEMBL:
Gene Tree for NDUFB1 (if available)
TreeFam:
Gene Tree for NDUFB1 (if available)

Paralogs for NDUFB1 Gene

Pseudogenes.org Pseudogenes for NDUFB1 Gene

genes like me logo Genes that share paralogs with NDUFB1: view

No data available for Paralogs for NDUFB1 Gene

Variants for NDUFB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NDUFB1 Gene

Variant ID Type Subtype PubMed ID
dgv1975n71 CNV Loss 21882294
nsv902190 CNV Loss 21882294
nsv819246 CNV Loss 19587683

Relevant External Links for NDUFB1 Gene

HapMap Linkage Disequilibrium report
NDUFB1
Human Gene Mutation Database (HGMD)
NDUFB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NDUFB1 Gene

Disorders for NDUFB1 Gene

No disorders were found for NDUFB1 Gene.

No data available for UniProtKB/Swiss-Prot for NDUFB1 Gene

Publications for NDUFB1 Gene

  1. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4
  4. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  5. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 3

Products for NDUFB1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDUFB1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFB1
    • Block miRNA regulation of NDUFB1 using miScript Target Protectors

    Sources for NDUFB1 Gene

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