Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NDUFB1 Gene

protein-coding   GIFtS: 55
GCID: GC14M092582

NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 1, 7kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1 (7kD,...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 1, 7kDa1 2     NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 1 (7kD, MNLL)1
Complex I MNLL Subunit1 2     CI-SGDH2
Complex I-MNLL2 3     MNLL2
CI-MNLL2 3     NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 12
NADH-Ubiquinone Oxidoreductase MNLL Subunit2 3     

External Ids:    HGNC: 76951   Entrez Gene: 47072   Ensembl: ENSG000001836487   OMIM: 6038375   UniProtKB: O754383   

Export aliases for NDUFB1 gene to outside databases

Previous GC identifers: GC14M090088 GC14M086398 GC14M090572 GC14M091652 GC14M072763


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NDUFB1 Gene:
NDUFB1 (NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa) is a protein-coding gene. Diseases associated with NDUFB1 include huntington's disease, and fatty liver disease. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NDUB1_HUMAN, O75438
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFB1 gene promoter:
         TBP   TFIID   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFB1 promoter sequence
   Search Chromatin IP Primers for NDUFB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.12   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q31.3

NDUFB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFB1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M092582:  view genomic region     (about GC identifiers)

Start:
92,582,466 bp from pter      End:
92,588,261 bp from pter
Size:
5,796 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NDUB1_HUMAN, O75438 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1  
Size: 58 amino acids; 6961 Da
Subunit: Complex I is composed of 45 different subunits
Sequence caution: Sequence=AAD42054.1; Type=Erroneous initiation;
Secondary accessions: A0AV68
Alternative splicing: 2 isoforms:  O75438-1   O75438-2   

Explore the universe of human proteins at neXtProt for NDUFB1: NX_O75438

Explore proteomics data for NDUFB1 at MOPED


See NDUFB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_004536.2  
ENSEMBL proteins: 
 ENSP00000451090   ENSP00000330787   ENSP00000475170   ENSP00000450776  
Reactome Protein details: O75438

NDUFB1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for NDUFB1
OriGene Custom MassSpec
OriGene Custom Protein Services for NDUFB1
GenScript Custom Purified and Recombinant Proteins Services for NDUFB1
Novus Biologicals NDUFB1 Protein
Novus Biologicals NDUFB1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp.

NDUFB1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
OriGene Antibodies for NDUFB1
OriGene Custom Antibody Services for NDUFB1
Novus Biologicals NDUFB1 Antibodies
Abcam antibodies for NDUFB1
Browse Antibodies at Cloud-Clone Corp.
Search ThermoFisher Antibodies for NDUFB1
LSBio Antibodies in human, mouse, rat for NDUFB1

NDUFB1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for NDUFB1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for NDUFB1
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
comI: Mitochondrial respiratory chain complex / Complex I

1 InterPro protein domain:
 IPR012575 NADH_UbQ_OxRdtase_MNLL_su

Graphical View of Domain Structure for InterPro Entry O75438

ProtoNet protein and cluster: O75438

1 Blocks protein domain: IPB012575 MNLL subunit

UniProtKB/Swiss-Prot: NDUB1_HUMAN, O75438
Similarity: Belongs to the complex I NDUFB1 subunit family


NDUFB1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: NDUB1_HUMAN, O75438
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

     Genatlas biochemistry entry for NDUFB1:
NADH ubiquinone oxidoreductase (Q reductase),7kDa,component beta 1,hydrophobic fraction of the complex I
multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003954NADH dehydrogenase activity ----
GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
     
NDUFB1 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for NDUFB1:
 Increased cell number in G2M,   Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFB1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NDUFB1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDUFB1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDUFB1

miRNA
Products:
    
miRTarBase miRNAs that target NDUFB1:
hsa-mir-26b-5p (MIRT029976)

Block miRNA regulation of human, mouse, rat NDUFB1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate NDUFB1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for NDUFB1
Predesigned siRNA for gene silencing in human, mouse, rat NDUFB1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for NDUFB1

Clone
Products:
     
OriGene clones in human, mouse for NDUFB1 (see all 7)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NDUFB1 (NM_004545)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFB1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for NDUFB1
Browse ESI BIO Cell Lines and PureStem Progenitors for NDUFB1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
NDUB1_HUMAN, O75438: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
cytosol1
endoplasmic reticulum1
extracellular1
lysosome1
plasma membrane1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0005743mitochondrial inner membrane TAS--
GO:0005747mitochondrial respiratory chain complex I NAS9878551
GO:0016021integral component of membrane IEA--

NDUFB1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for NDUFB1 About    
See pathways by source

SuperPathSelected contained pathways About (see all per SuperPath)
1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
Parkinson's disease0.57
Respiratory electron transport0.81
Oxidative phosphorylation0.51
Electron Transport Chain0.75
Huntington's disease0.45
The citric acid (TCA) cycle and respiratory electron transport0.71
Non-alcoholic fatty liver disease (NAFLD)0.41
2Metabolism
Metabolism0.38
Metabolic pathways0.38
3Alzheimer's disease
Alzheimer's disease0.44

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


2 BioSystems Pathways for NDUFB1
    Oxidative phosphorylation
Electron Transport Chain

1 Reactome Pathway for NDUFB1
    Respiratory electron transport


Selected Kegg Pathways  (Kegg details for NDUFB1) (see all 6):
    Oxidative phosphorylation
Metabolic pathways
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Parkinson's disease


NDUFB1 for pathways           About GeneDecksing

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDUFB1
Interactions:

    Search GeneGlobe Interaction Network for NDUFB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for NDUFB1 (O754382, 3 ENSP000003307874) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
InteractantInteraction Details
GeneCardExternal ID(s)
NDUFA5Q167183, ENSP000003479884I2D: score=4 STRING: ENSP00000347988
EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
U2AF2P263683I2D: score=1 
NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
MT-CYBENSP000003545544STRING: ENSP00000354554
About this table

Gene Ontology (GO): 4 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
GO:0022904respiratory electron transport chain TAS--
GO:0044237cellular metabolic process TAS--
GO:0044281small molecule metabolic process TAS--

NDUFB1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for NDUFB1 (NDUB1)

8 HMDB Compounds for NDUFB1    About this table
CompoundSynonyms CAS #PubMed Ids
FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
IronArmco iron (see all 19)7439-89-6--
NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
QH2CoQH2 (see all 5)56275-39-9--
SulfideSulfide (see all 4)18496-25-8--
Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

1 DrugBank Compound for NDUFB1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for NDUFB1 gene: 
NM_004545.3  

Unigene Cluster for NDUFB1:

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
Hs.183435  [show with all ESTs]
Unigene Representative Sequence: AK055348
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000553514(uc001yag.1) ENST00000329559(uc001yaf.3) ENST00000605997
ENST00000553666 ENST00000555441 ENST00000556555
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat NDUFB1 using miScript Target Protectors
Search for qRT-PCR Assays for microRNAs that regulate NDUFB1
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for NDUFB1
Predesigned siRNA for gene silencing in human, mouse, rat NDUFB1
Clone
Products:
     
OriGene clones in human, mouse for NDUFB1 (see all 7)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: NDUFB1 (NM_004545)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFB1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for NDUFB1
OriGene qSTAR qPCR primer pairs in human, mouse for NDUFB1
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NDUFB1
  QuantiTect SYBR Green Assays in human, mouse, rat NDUFB1
  QuantiFast Probe-based Assays in human, mouse, rat NDUFB1

Additional mRNA sequence: 

AF050638.1 AK055348.1 AK316557.2 BC009691.1 BC104672.1 BC126232.1 BC126234.1 

9 DOTS entries:

DT.453834  DT.86858664  DT.120776662  DT.97773970  DT.99982845  DT.100741831  DT.91717438  DT.120776631 
DT.40188944 

Selected AceView cDNA sequences (see all 118):

NM_004545 AI123327 AI659639 AI247288 BQ889160 AA887927 BM052981 AA595029 
AI674188 AA257014 BF084212 CB106791 BI712526 BC009691 AA541407 AA257100 
CK903925 BG337256 AL699842 AI222803 BQ271790 BG149304 AA514390 AF050638 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

NDUFB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGAATCTGA
NDUFB1 Expression
About this image

NDUFB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

NDUFB1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.183435
    Custom PCR Arrays for NDUFB1
Primer
Products:
OriGene qPCR primer pairs and template standards for NDUFB1
OriGene qSTAR qPCR primer pairs in human, mouse for NDUFB1
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NDUFB1
QuantiTect SYBR Green Assays in human, mouse, rat NDUFB1
QuantiFast Probe-based Assays in human, mouse, rat NDUFB1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for NDUFB1 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia LOC1026319121 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit more 83.04(n)
75.44(a)
  102631912  XM_006516441.1  XP_006516504.1 
chicken
(Gallus gallus)
Aves NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, more 70.11(n)
75.86(a)
  423415  NM_001277787.1  NP_001264716.1 
lizard
(Anolis carolinensis)
Reptilia NDUFB16
NADH dehydrogenase (ubiquinone) 1 beta subcomplex,...
62(a)
1 ↔ 1
1(11644897-11645022)
African clawed frog
(Xenopus laevis)
Amphibia Xl.66432 Xenopus laevis transcribed sequence with moderate similarity more 75.92(n)    AW636101.1 
zebrafish
(Danio rerio)
Actinopterygii BI842206.12   -- 71.58(n)    BI842206.1 


ENSEMBL Gene Tree for NDUFB1 (if available)
TreeFam Gene Tree for NDUFB1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for NDUFB1 gene

NDUFB1 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for NDUFB1
PGOHUM00000245216 PGOHUM00000238028


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for NDUFB1 (see all 107)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1166657361,2
C,F--92582008(+) AAATCT/CTGGCA 1 -- int11Minor allele frequency- C:0.03WA 118
rs773952051,2
C,F--92582031(+) AGTCCC/TGTTGA 1 -- int11Minor allele frequency- T:0.03EA 120
rs1473715111,2
--92582159(+) ACCACA/GGTATA 1 -- int10--------
rs24021121,2
C,F,H--92582172(+) ATCAGG/ATACCT 1 -- int115Minor allele frequency- A:0.27NS EA NA WA CSA 925
rs1888975701,2
C--92582228(+) ACTCTA/GTTGCC 1 -- int10--------
rs28961971,2
C,F,A,H--92582251(+) TATGCG/ACCACC 1 -- int111Minor allele frequency- A:0.39NA WA CSA EA 373
rs28961981,2
C,A,H--92582291(+) AGAGAT/CGGGGT 1 -- int15Minor allele frequency- C:0.11NA WA CSA 9
rs133501,2
C,F,H--92582472(-) AGAATT/CTGAAA 1 -- ut3122Minor allele frequency- C:0.06NS EA WA NA CSA 2349
rs1999193111,2
C--92582581(+) GTGTGA/GAAAGC 1 -- int10--------
rs111600441,2
C,F,A,H--92582655(+) AAGAAT/AGATTG 1 -- int112Minor allele frequency- A:0.34NS EA NA WA 784

HapMap Linkage Disequilibrium report for NDUFB1 (92582466 - 92588261 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for NDUFB1:    About this table    
Variant IDTypeSubtypePubMed ID
dgv1975n71CNV Loss21882294
nsv902190CNV Loss21882294
nsv819246CNV Loss19587683

Human Gene Mutation Database (HGMD): NDUFB1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing NDUFB1
DNA2.0 Custom Variant and Variant Library Synthesis for NDUFB1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 603837    OMIM disorders: --

5 diseases for NDUFB1:    
About MalaCards
huntington's disease    fatty liver disease    parkinson's disease    alzheimer's disease
liver disease


NDUFB1 for disorders           About GeneDecksing


Export disorders for NDUFB1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for NDUFB1 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with NDUFB1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  2. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
  3. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
  4. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (Cytogenet. Cell Genet. 1998)
  5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
  6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  9. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
  10. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 4707 HGNC: 7695 AceView: NDUFB1 Ensembl:ENSG00000183648 euGenes: HUgn4707
ECgene: NDUFB1 Kegg: 4707 H-InvDB: NDUFB1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for NDUFB1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for NDUFB1 gene:
Search GeneIP for patents involving NDUFB1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 OriGene Antibodies for NDUFB1   OriGene RNAi products in human, mouse, rat for NDUFB1  
 OriGene qPCR primer pairs and template standards for NDUFB1   OriGene Protein Over-expression Lysate for NDUFB1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for NDUFB1  
 OriGene qSTAR qPCR primer pairs in human, mouse for NDUFB1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for NDUFB1   OriGene Custom Protein Services for NDUFB1  

 
 
 Block miRNA regulation of human, mouse, rat NDUFB1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NDUFB1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFB1 Predesigned siRNA for gene silencing in human, mouse, rat NDUFB1
 QuantiFast Probe-based Assays in human, mouse, rat NDUFB1 QuantiTect SYBR Green Assays in human, mouse, rat NDUFB1
 Custom PCR Arrays for NDUFB1 Search Chromatin IP Primers for NDUFB1
 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NDUFB1  Search GeneGlobe Interaction Network for NDUFB1
 Regulatory tfbs in NDUFB1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for NDUFB1 GenScript cDNA clones with any tag delivered in your preferred vector for NDUFB1
 GenScript Custom Assay Services for NDUFB1 GenScript Custom overexpressing Cell Line Services for NDUFB1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for NDUFB1 (NDUB1)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 NDUFB1 antibodies
 NDUFB1 proteins
 NDUFB1 lysates
 Antibodies for NDUFB1
 See all of Abcam's Antibodies, Kits and Proteins for NDUFB1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.



 Browse ESI BIO Cell Lines and PureStem Progenitors for NDUFB1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFB1
 Browse SwitchGear 3'UTR luciferase reporter plasmids for NDUFB1
 SwitchGear Promoter luciferase reporter plasmids for NDUFB1
 Search ThermoFisher Antibodies for NDUFB1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFB1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFB1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NDUFB1
 LSBio Antibodies in human, mouse, rat for NDUFB1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      NDUFB1 gene at Home site.
Version: 3.12.166 28 Aug 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4