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Aliases for NDUFB1 Gene

Aliases for NDUFB1 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit B1 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 1, 7kDa 2 3
  • NADH-Ubiquinone Oxidoreductase MNLL Subunit 3 4
  • Complex I MNLL Subunit 2 3
  • Complex I-MNLL 3 4
  • CI-MNLL 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 1 (7kD, MNLL) 2
  • CI-SGDH 3
  • MNLL 3

External Ids for NDUFB1 Gene

Previous GeneCards Identifiers for NDUFB1 Gene

  • GC14M090088
  • GC14M086398
  • GC14M090572
  • GC14M091652
  • GC14M092582
  • GC14M072763

Summaries for NDUFB1 Gene

GeneCards Summary for NDUFB1 Gene

NDUFB1 (NADH:Ubiquinone Oxidoreductase Subunit B1) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity.

UniProtKB/Swiss-Prot for NDUFB1 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Wiki entry for NDUFB1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFB1 Gene

Genomics for NDUFB1 Gene

Regulatory Elements for NDUFB1 Gene

Enhancers for NDUFB1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NDUFB1 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDUFB1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NDUFB1 gene promoter:

Genomic Location for NDUFB1 Gene

Chromosome:
14
Start:
92,116,122 bp from pter
End:
92,121,917 bp from pter
Size:
5,796 bases
Orientation:
Minus strand

Genomic View for NDUFB1 Gene

Genes around NDUFB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFB1 Gene

Proteins for NDUFB1 Gene

  • Protein details for NDUFB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75438-NDUB1_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
    Protein Accession:
    O75438
    Secondary Accessions:
    • A0AV68

    Protein attributes for NDUFB1 Gene

    Size:
    58 amino acids
    Molecular mass:
    6961 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.
    SequenceCaution:
    • Sequence=AAD42054.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NDUFB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFB1 Gene

Proteomics data for NDUFB1 Gene at MOPED

Post-translational modifications for NDUFB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFB1 Gene

No data available for DME Specific Peptides for NDUFB1 Gene

Domains & Families for NDUFB1 Gene

Protein Domains for NDUFB1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFB1 Gene

Graphical View of Domain Structure for InterPro Entry

O75438

UniProtKB/Swiss-Prot:

NDUB1_HUMAN :
  • Belongs to the complex I NDUFB1 subunit family.
Family:
  • Belongs to the complex I NDUFB1 subunit family.
genes like me logo Genes that share domains with NDUFB1: view

Function for NDUFB1 Gene

Molecular function for NDUFB1 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),7kDa,component beta 1,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
genes like me logo Genes that share phenotypes with NDUFB1: view

Animal Model Products

CRISPR Products

miRNA for NDUFB1 Gene

miRTarBase miRNAs that target NDUFB1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFB1 Gene

Localization for NDUFB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFB1 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFB1 Gene COMPARTMENTS Subcellular localization image for NDUFB1 gene
Compartment Confidence
extracellular 5
mitochondrion 5
cytosol 1
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NDUFB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NDUFB1: view

Pathways & Interactions for NDUFB1 Gene

genes like me logo Genes that share pathways with NDUFB1: view

Interacting Proteins for NDUFB1 Gene

Gene Ontology (GO) - Biological Process for NDUFB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
genes like me logo Genes that share ontologies with NDUFB1: view

No data available for SIGNOR curated interactions for NDUFB1 Gene

Drugs & Compounds for NDUFB1 Gene

(5) Drugs for NDUFB1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFB1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFB1: view

Transcripts for NDUFB1 Gene

Unigene Clusters for NDUFB1 Gene

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFB1 Gene

No ASD Table

Relevant External Links for NDUFB1 Gene

GeneLoc Exon Structure for
NDUFB1
ECgene alternative splicing isoforms for
NDUFB1

Expression for NDUFB1 Gene

mRNA expression in normal human tissues for NDUFB1 Gene

Protein differential expression in normal tissues from HIPED for NDUFB1 Gene

This gene is overexpressed in Heart (13.4) and Peripheral blood mononuclear cells (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFB1 Gene



SOURCE GeneReport for Unigene cluster for NDUFB1 Gene Hs.183435

genes like me logo Genes that share expression patterns with NDUFB1: view

Protein tissue co-expression partners for NDUFB1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFB1 Gene

Orthologs for NDUFB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFB1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFB1 35
  • 89.66 (n)
  • 82.76 (a)
NDUFB1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102156783 35
  • 80.18 (n)
  • 71.62 (a)
mouse
(Mus musculus)
Mammalia LOC102631912 35
  • 83.04 (n)
  • 75.44 (a)
Gm2695 16
chimpanzee
(Pan troglodytes)
Mammalia NDUFB1 35
  • 99.68 (n)
  • 100 (a)
NDUFB1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFB1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFB1 36
  • 20 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDUFB1 35
  • 70.11 (n)
  • 75.86 (a)
NDUFB1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFB1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3020 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6643 35
zebrafish
(Danio rerio)
Actinopterygii NDUFB1 36
  • 64 (a)
OneToOne
Species with no ortholog for NDUFB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFB1 Gene

ENSEMBL:
Gene Tree for NDUFB1 (if available)
TreeFam:
Gene Tree for NDUFB1 (if available)

Paralogs for NDUFB1 Gene

Pseudogenes.org Pseudogenes for NDUFB1 Gene

genes like me logo Genes that share paralogs with NDUFB1: view

No data available for Paralogs for NDUFB1 Gene

Variants for NDUFB1 Gene

Sequence variations from dbSNP and Humsavar for NDUFB1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs13350 -- 92,116,128(-) AGAAT(C/T)TGAAA utr-variant-3-prime
rs2896197 -- 92,115,907(+) TATGC(A/G)CCACC downstream-variant-500B
rs2896198 -- 92,115,947(+) AGAGA(C/T)GGGGT downstream-variant-500B
rs3814832 -- 92,117,437(-) TGATA(C/T)GTGCC intron-variant
rs3814833 -- 92,117,235(-) TAATA(C/T)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFB1 Gene

Variant ID Type Subtype PubMed ID
dgv1975n71 CNV Loss 21882294
nsv902190 CNV Loss 21882294
nsv819246 CNV Loss 19587683

Variation tolerance for NDUFB1 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFB1 Gene

Human Gene Mutation Database (HGMD)
NDUFB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFB1 Gene

Disorders for NDUFB1 Gene

Relevant External Links for NDUFB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFB1

No disorders were found for NDUFB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFB1 Gene

Publications for NDUFB1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3

Products for NDUFB1 Gene

Sources for NDUFB1 Gene

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