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Aliases for NDUFAF7 Gene

Aliases for NDUFAF7 Gene

  • NADH Dehydrogenase (Ubiquinone) Complex I, Assembly Factor 7 2 3
  • Mitochondrial Dysfunction Protein A Homolog 2 3
  • Protein MidA Homolog, Mitochondrial 3 4
  • C2orf56 3 4
  • NADH Dehydrogenase [Ubiquinone] Complex I, Assembly Factor 7 3
  • Chromosome 2 Open Reading Frame 56 2
  • PRO1853 3
  • MidA 3

External Ids for NDUFAF7 Gene

Previous Symbols for NDUFAF7 Gene

  • C2orf56

Summaries for NDUFAF7 Gene

GeneCards Summary for NDUFAF7 Gene

NDUFAF7 (NADH Dehydrogenase (Ubiquinone) Complex I, Assembly Factor 7) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and methyltransferase activity.

UniProtKB/Swiss-Prot for NDUFAF7 Gene

  • Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFAF7 Gene

Genomics for NDUFAF7 Gene

Genomic Location for NDUFAF7 Gene

37,231,631 bp from pter
37,253,403 bp from pter
21,773 bases
Plus strand

Genomic View for NDUFAF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFAF7 Gene

No data available for Regulatory Elements for NDUFAF7 Gene

Proteins for NDUFAF7 Gene

  • Protein details for NDUFAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADH dehydrogenase [ubiquinone] complex I, assembly factor 7
    Protein Accession:
    Secondary Accessions:
    • Q7Z399
    • Q9P1G3

    Protein attributes for NDUFAF7 Gene

    441 amino acids
    Molecular mass:
    49238 Da
    Quaternary structure:
    • Homodimer. Interacts with NDUFS2.
    • Sequence=AAF71091.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12374.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NDUFAF7 Gene


neXtProt entry for NDUFAF7 Gene

Proteomics data for NDUFAF7 Gene at MOPED

Post-translational modifications for NDUFAF7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys191

No data available for DME Specific Peptides for NDUFAF7 Gene

Domains for NDUFAF7 Gene

Gene Families for NDUFAF7 Gene

  • MITOAF :Mitochondrial respiratory chain complex assembly factors

Protein Domains for NDUFAF7 Gene



  • Belongs to the NDUFAF7 family.:
    • Q7L592
genes like me logo Genes that share domains with NDUFAF7: view

Function for NDUFAF7 Gene

Molecular function for NDUFAF7 Gene

UniProtKB/Swiss-Prot Function: Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).

Gene Ontology (GO) - Molecular Function for NDUFAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity NAS 20406883
GO:0019899 enzyme binding IPI 20406883
genes like me logo Genes that share ontologies with NDUFAF7: view

Phenotypes for NDUFAF7 Gene

genes like me logo Genes that share phenotypes with NDUFAF7: view

miRNA for NDUFAF7 Gene

miRTarBase miRNAs that target NDUFAF7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFAF7 Gene

Localization for NDUFAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFAF7 Gene


Gene Ontology (GO) - Cellular Components for NDUFAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005739 mitochondrion IDA 20406883
genes like me logo Genes that share ontologies with NDUFAF7: view

Pathways for NDUFAF7 Gene

SuperPathways for NDUFAF7 Gene

No Data Available

Interacting Proteins for NDUFAF7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000002125 for NDUFAF7 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NDUFAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation NAS 20406883
GO:0032981 mitochondrial respiratory chain complex I assembly IMP 20406883
genes like me logo Genes that share ontologies with NDUFAF7: view

No data available for Pathways by source for NDUFAF7 Gene

Transcripts for NDUFAF7 Gene

Unigene Clusters for NDUFAF7 Gene

NADH dehydrogenase (ubiquinone) complex I, assembly factor 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFAF7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - -
SP8: - - - - - - - - - -
SP9: -
SP11: - - -

Relevant External Links for NDUFAF7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NDUFAF7 Gene

mRNA expression in normal human tissues for NDUFAF7 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NDUFAF7 Gene

SOURCE GeneReport for Unigene cluster for NDUFAF7 Gene Hs.433466

genes like me logo Genes that share expressions with NDUFAF7: view

Orthologs for NDUFAF7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDUFAF7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NDUFAF7 36
  • 99.55 (n)
  • 99.55 (a)
  • 100 (a)
(Bos Taurus)
Mammalia NDUFAF7 36
  • 87.5 (n)
  • 84.32 (a)
  • 84 (a)
(Canis familiaris)
Mammalia NDUFAF7 36
  • 87.42 (n)
  • 87.05 (a)
  • 87 (a)
(Mus musculus)
Mammalia Ndufaf7 36
  • 85.05 (n)
  • 85.05 (a)
Ndufaf7 16
Ndufaf7 37
  • 84 (a)
(Monodelphis domestica)
Mammalia NDUFAF7 37
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
-- 37
  • 71 (a)
(Rattus norvegicus)
Mammalia Ndufaf7 36
  • 83.8 (n)
  • 83.64 (a)
(Gallus gallus)
Aves C2ORF56 36
  • 69.13 (n)
  • 69.13 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia NDUFAF7 37
  • 63 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6981 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufaf7 36
  • 66.17 (n)
  • 62.5 (a)
Str.3484 36
(Danio rerio)
Actinopterygii ndufaf7 36
  • 61.05 (n)
  • 64.03 (a)
ndufaf7 37
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004909 36
  • 50.59 (n)
  • 47.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17726 36
  • 50.72 (n)
  • 49.73 (a)
CG17726 37
  • 44 (a)
(Caenorhabditis elegans)
Secernentea ZK1128.1 36
  • 50.48 (n)
  • 42.82 (a)
ZK1128.1 37
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G28700 36
  • 52.42 (n)
  • 41.86 (a)
(Oryza sativa)
Liliopsida Os.26711 36
Os01g0588800 36
  • 51.59 (n)
  • 42.61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00183 36
  • 46.96 (n)
  • 40.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 50 (a)
Species with no ortholog for NDUFAF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFAF7 Gene

Gene Tree for NDUFAF7 (if available)
Gene Tree for NDUFAF7 (if available)

Paralogs for NDUFAF7 Gene Pseudogenes for NDUFAF7 Gene

genes like me logo Genes that share paralogs with NDUFAF7: view

No data available for Paralogs for NDUFAF7 Gene

Variants for NDUFAF7 Gene

Sequence variations from dbSNP and Humsavar for NDUFAF7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs759461 -- 37,246,512(-) GGGGG(G/T)TACAG intron-variant
rs1861444 -- 37,237,368(-) GATAC(C/G)CACAT intron-variant
rs2041837 -- 37,241,421(-) GAATC(A/C)TAACC intron-variant
rs2041838 -- 37,241,305(-) TAAAA(A/C/G)CAATG intron-variant
rs2041839 -- 37,240,196(-) gcctc(A/G)aactc intron-variant

Relevant External Links for NDUFAF7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Structural Variations from Database of Genomic Variants (DGV) for NDUFAF7 Gene

Disorders for NDUFAF7 Gene

No disorders were found for NDUFAF7 Gene.

No data available for UniProtKB/Swiss-Prot for NDUFAF7 Gene

Publications for NDUFAF7 Gene

  1. MidA is a putative methyltransferase that is required for mitochondrial complex I function. (PMID: 20406883) Carilla-Latorre S. … Escalante R. (J. Cell Sci. 2010) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3

Products for NDUFAF7 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDUFAF7
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFAF7
    • Block miRNA regulation of NDUFAF7 using miScript Target Protectors

    Sources for NDUFAF7 Gene

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