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Aliases for NDUFAF7 Gene

Aliases for NDUFAF7 Gene

  • NADH Dehydrogenase (Ubiquinone) Complex I, Assembly Factor 7 2 3
  • Mitochondrial Dysfunction Protein A Homolog 2 3
  • Protein MidA Homolog, Mitochondrial 3 4
  • C2orf56 3 4
  • NADH Dehydrogenase [Ubiquinone] Complex I, Assembly Factor 7 3
  • Chromosome 2 Open Reading Frame 56 2
  • PRO1853 3
  • MidA 3

External Ids for NDUFAF7 Gene

Previous HGNC Symbols for NDUFAF7 Gene

  • C2orf56

Previous GeneCards Identifiers for NDUFAF7 Gene

  • GC02P037460

Summaries for NDUFAF7 Gene

GeneCards Summary for NDUFAF7 Gene

NDUFAF7 (NADH Dehydrogenase (Ubiquinone) Complex I, Assembly Factor 7) is a Protein Coding gene. GO annotations related to this gene include enzyme binding and methyltransferase activity.

UniProtKB/Swiss-Prot for NDUFAF7 Gene

  • Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFAF7 Gene

Genomics for NDUFAF7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDUFAF7 Gene

Start:
37,231,631 bp from pter
End:
37,253,403 bp from pter
Size:
21,773 bases
Orientation:
Plus strand

Genomic View for NDUFAF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFAF7 Gene

No data available for Regulatory Elements for NDUFAF7 Gene

Proteins for NDUFAF7 Gene

  • Protein details for NDUFAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L592-NDUF7_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] complex I, assembly factor 7
    Protein Accession:
    Q7L592
    Secondary Accessions:
    • Q7Z399
    • Q9P1G3

    Protein attributes for NDUFAF7 Gene

    Size:
    441 amino acids
    Molecular mass:
    49238 Da
    Quaternary structure:
    • Homodimer. Interacts with NDUFS2.
    SequenceCaution:
    • Sequence=AAF71091.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH12374.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NDUFAF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFAF7 Gene

Proteomics data for NDUFAF7 Gene at MOPED

Post-translational modifications for NDUFAF7 Gene

  • Ubiquitination at Lys191
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NDUFAF7 Gene

Domains for NDUFAF7 Gene

Gene Families for NDUFAF7 Gene

HGNC:
  • MITOAF :Mitochondrial respiratory chain complex assembly factors

Protein Domains for NDUFAF7 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7L592

UniProtKB/Swiss-Prot:

NDUF7_HUMAN :
  • Q7L592
Family:
  • Belongs to the NDUFAF7 family.
genes like me logo Genes that share domains with NDUFAF7: view

No data available for Suggested Antigen Peptide Sequences for NDUFAF7 Gene

Function for NDUFAF7 Gene

Molecular function for NDUFAF7 Gene

UniProtKB/Swiss-Prot Function:
Involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).

Gene Ontology (GO) - Molecular Function for NDUFAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity NAS 20406883
GO:0019899 enzyme binding IPI 20406883
genes like me logo Genes that share ontologies with NDUFAF7: view

Phenotypes for NDUFAF7 Gene

genes like me logo Genes that share phenotypes with NDUFAF7: view

Animal Model Products

CRISPR Products

miRNA for NDUFAF7 Gene

miRTarBase miRNAs that target NDUFAF7

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFAF7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFAF7 Gene

Localization for NDUFAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFAF7 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for NDUFAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005739 mitochondrion IDA 20406883
genes like me logo Genes that share ontologies with NDUFAF7: view

No data available for Subcellular locations from COMPARTMENTS for NDUFAF7 Gene

Pathways for NDUFAF7 Gene

SuperPathways for NDUFAF7 Gene

No Data Available

Interacting Proteins for NDUFAF7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000002125%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000002125 for NDUFAF7 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for NDUFAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation NAS 20406883
GO:0032981 mitochondrial respiratory chain complex I assembly IMP 20406883
genes like me logo Genes that share ontologies with NDUFAF7: view

No data available for Pathways by source for NDUFAF7 Gene

Transcripts for NDUFAF7 Gene

Unigene Clusters for NDUFAF7 Gene

NADH dehydrogenase (ubiquinone) complex I, assembly factor 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFAF7

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFAF7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - -
SP5: - - - - - - - - -
SP6: - -
SP7: - - -
SP8: - - - - - - - - - -
SP9: -
SP10:
SP11: - - -

Relevant External Links for NDUFAF7 Gene

GeneLoc Exon Structure for
NDUFAF7
ECgene alternative splicing isoforms for
NDUFAF7

Expression for NDUFAF7 Gene

mRNA expression in normal human tissues for NDUFAF7 Gene

Protein differential expression in normal tissues for NDUFAF7 Gene

This gene is overexpressed in Heart (11.5) and Salivary gland (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NDUFAF7 Gene

SOURCE GeneReport for Unigene cluster for NDUFAF7 Gene Hs.433466

genes like me logo Genes that share expressions with NDUFAF7: view

Expression partners for NDUFAF7 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFAF7 Gene

Orthologs for NDUFAF7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDUFAF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFAF7 35
  • 87.5 (n)
  • 84.32 (a)
NDUFAF7 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFAF7 35
  • 87.42 (n)
  • 87.05 (a)
NDUFAF7 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufaf7 35
  • 85.05 (n)
  • 85.05 (a)
Ndufaf7 16
Ndufaf7 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDUFAF7 35
  • 99.55 (n)
  • 99.55 (a)
NDUFAF7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufaf7 35
  • 83.8 (n)
  • 83.64 (a)
oppossum
(Monodelphis domestica)
Mammalia NDUFAF7 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves C2ORF56 35
  • 69.13 (n)
  • 69.13 (a)
NDUFAF7 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFAF7 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufaf7 35
  • 66.17 (n)
  • 62.5 (a)
Str.3484 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6981 35
zebrafish
(Danio rerio)
Actinopterygii ndufaf7 35
  • 61.05 (n)
  • 64.03 (a)
ndufaf7 36
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004909 35
  • 50.59 (n)
  • 47.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17726 35
  • 50.72 (n)
  • 49.73 (a)
CG17726 36
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK1128.1 35
  • 50.48 (n)
  • 42.82 (a)
ZK1128.1 36
  • 35 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G28700 35
  • 52.42 (n)
  • 41.86 (a)
rice
(Oryza sativa)
Liliopsida Os.26711 35
Os01g0588800 35
  • 51.59 (n)
  • 42.61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00183 35
  • 46.96 (n)
  • 40.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for NDUFAF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFAF7 Gene

ENSEMBL:
Gene Tree for NDUFAF7 (if available)
TreeFam:
Gene Tree for NDUFAF7 (if available)

Paralogs for NDUFAF7 Gene

Pseudogenes.org Pseudogenes for NDUFAF7 Gene

genes like me logo Genes that share paralogs with NDUFAF7: view

No data available for Paralogs for NDUFAF7 Gene

Variants for NDUFAF7 Gene

Sequence variations from dbSNP and Humsavar for NDUFAF7 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs759461 -- 37,246,512(-) GGGGG(G/T)TACAG intron-variant
rs1861444 -- 37,237,368(-) GATAC(C/G)CACAT intron-variant
rs2041837 -- 37,241,421(-) GAATC(A/C)TAACC intron-variant
rs2041838 -- 37,241,305(-) TAAAA(A/C/G)CAATG intron-variant
rs2041839 -- 37,240,196(-) gcctc(A/G)aactc intron-variant

Relevant External Links for NDUFAF7 Gene

HapMap Linkage Disequilibrium report
NDUFAF7
Human Gene Mutation Database (HGMD)
NDUFAF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFAF7 Gene

Disorders for NDUFAF7 Gene

No disorders were found for NDUFAF7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NDUFAF7 Gene

Publications for NDUFAF7 Gene

  1. MidA is a putative methyltransferase that is required for mitochondrial complex I function. (PMID: 20406883) Carilla-Latorre S. … Escalante R. (J. Cell Sci. 2010) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. (PMID: 22664934) BAPhm D. … Grus F.H. (Oncol. Rep. 2012) 3

Products for NDUFAF7 Gene

Sources for NDUFAF7 Gene

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