Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDUFAB1 Gene

protein-coding   GIFtS: 57
GCID: GC16M023592

NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex,...

(Previous names: NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex,...)
 Explore 10 diseases affiliated with
NDUFAB1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NDUFAB1    

Aliases
for NDUFAB1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NADH Dehydrogenase (Ubiquinone) 1, Alpha/Beta Subcomplex, 1, 8kDa1 2     NADH Dehydrogenase (Ubiquinone) 1, Alpha/Beta Subcomplex, 1 (8kD, SDAP)1
ACP1 2 3     Acyl Carrier Protein, Mitochondrial2
FASN2A1 2     Complex I SDAP Subunit2
SDAP1 2     Mitochondrial Acyl Carrier Protein2
CI-SDAP2 3     NADH:Ubiquinone Oxidoreductase SDAP Subunit2
NADH-Ubiquinone Oxidoreductase 9.6 KDa Subunit2 3     

External Ids:    HGNC: 76941   Entrez Gene: 47062   Ensembl: ENSG000000047797   OMIM: 6038365   UniProtKB: O145613   

Export aliases for NDUFAB1 gene to outside databases

Previous GC identifers: GC16M023000 GC16M023680 GC16M023519 GC16M023558 GC16M023499 GC16M021682


Summaries
for NDUFAB1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ACPM_HUMAN, O14561
Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and
non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions
in the transfer of electrons from NADH to the respiratory chain (By similarity)




Genomic Views
for NDUFAB1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDUFAB1 gene promoter:
         SRF   AP-1   SRF (504 AA)   ATF-2   HNF-4alpha1   POU2F1   POU2F1a   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NDUFAB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDUFAB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFAB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.3

NDUFAB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFAB1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M023592:  view genomic region     (about GC identifiers)

Start:
 23,592,323 bp from pter      End:
 23,607,677 bp from pter
Size:
 15,355 bases      Orientation:
 minus strand

Proteins
for NDUFAB1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ACPM_HUMAN, O14561 (See protein sequence)
Recommended Name: Acyl carrier protein, mitochondrial precursor  
Size: 156 amino acids; 17417 Da
Subunit: Mammalian complex I is composed of 45 different subunits
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAC05814.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for NDUFAB1:
2DNW (3D)    
Secondary accessions: B2R4M1 Q9UNV1

Explore the universe of human proteins at neXtProt for NDUFAB1: NX_O14561

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14561

    • NDUFAB1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004994.1  
    ENSEMBL proteins: 
     ENSP00000007516   ENSP00000454891   ENSP00000454812   ENSP00000458770   ENSP00000461693  
    Reactome Protein details: O14561
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NDUFAB1
    OriGene Protein Over-expression Lysate: NDUFAB1
    OriGene Custom Protein Services for NDUFAB1 
    GenScript Custom Purified and Recombinant Proteins Services for NDUFAB1
    Novus Biologicals NDUFAB1 Protein
    Novus Biologicals NDUFAB1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NDUFAB1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0005759mitochondrial matrix ISS--
    GO:0031966mitochondrial membrane NAS10234612


    NDUFAB1 for ontologies           About GeneDecksing



    NDUFAB1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: NDUFAB1
    OriGene Custom Antibody Services for NDUFAB1 
    GenScript Custom Superior Antibodies Services for NDUFAB1
    Novus Biologicals NDUFAB1 Antibodies
    Search for Antibodies for NDUFAB1 at Abcam  
    Uscn Antibodies for NDUFAB1
    ThermoFisher Antibodies for NDUFAB1

    Assay Products for NDUFAB1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NDUFAB1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NDUFAB1

    Protein Domains /
    Families
    for NDUFAB1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NDUFAB1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006162 PPantetheine_attach_site
     IPR003231 Acyl_carrier
     IPR009081 Acyl_carrier_prot-like

    Graphical View of Domain Structure for InterPro Entry O14561

    ProtoNet protein and cluster: O14561

    1 Blocks protein family: IPB006162 Phosphopantetheine attachment site

    UniProtKB/Swiss-Prot: ACPM_HUMAN, O14561
    Similarity: Contains 1 acyl carrier domain


    Function
    for NDUFAB1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ACPM_HUMAN, O14561
    Function: Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and
    non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions
    in the transfer of electrons from NADH to the respiratory chain (By similarity)

         Genatlas biochemistry entry for NDUFAB1:
    NADH ubiquinone oxidoreductase (Q reductase),8kDa,component alpha/beta 1,hydrophobic fraction of the complex I
    multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

    miRNA
    Products:            		 OriGene 3'-UTR Clone: NDUFAB1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDUFAB1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NDUFAB1:
    hsa-miR-300 hsa-miR-381
    SwitchGear 3'UTR luciferase reporter plasmid: NDUFAB1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NDUFAB1 (see all 7)
    OriGene shRNA RFP: NDUFAB1
    OriGene siRNA: NDUFAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFAB1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NDUFAB1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFAB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFAB1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NDUFAB1 (NM_005003)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFAB1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NDUFAB1
    Search LifeMap BioReagents cell lines for NDUFAB1

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NDUFAB1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000036ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process NAS10234612
    GO:0005504fatty acid binding ISS--
    GO:0005509calcium ion binding NAS10234612
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
    GO:0031177phosphopantetheine binding ----


    NDUFAB1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NDUFAB1:
     Decreased viability 


    Pathways & Interactions
    for NDUFAB1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    8/9 pathways (see all 9)
    		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.1.00
    		Parkinson's disease0.61
    		Respiratory electron transport0.81
    		Oxidative phosphorylation0.52
    		Electron Transport Chain0.76
    		Alzheimer's disease0.43
    		The citric acid (TCA) cycle and respiratory electron transport0.72
    		Huntington's disease0.40
    2Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    3Saturated fatty acid biosynthesis
    		palmitate biosynthesis I (animals)0.17
    		fatty acid biosynthesis initiation II0.17
    4Metformin Pathway, Pharmacodynamic
    		Metformin Pathway, Pharmacodynamic1.00
    5acyl carrier protein metabolism
    		acyl carrier protein metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5 BioSystems Pathways for NDUFAB1 
        Electron Transport Chain
    Oxidative phosphorylation
    acyl carrier protein metabolism
    fatty acid biosynthesis initiation II
    palmitate biosynthesis I (animals)

    4        Reactome Pathways for NDUFAB1
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport

    1 PharmGKB Pathway for NDUFAB1
        Metformin Pathway, Pharmacodynamic

    5         Kegg Pathways  (Kegg details for NDUFAB1):
        Oxidative phosphorylation
    Metabolic pathways
    Alzheimer's disease
    Parkinson's disease
    Huntington's disease


    NDUFAB1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFAB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/81 Interacting proteins for NDUFAB1 (O145613 ENSP000000075164) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ORC4O439293, ENSP000002641694I2D: score=4 STRING: ENSP00000264169
    DENRO435833, ENSP000002805574I2D: score=2 STRING: ENSP00000280557
    ZNHIT1O432573I2D: score=2 
    NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
    CYC1ENSP000003171594STRING: ENSP00000317159
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0006633fatty acid biosynthetic process NAS10234612
    GO:0009249protein lipoylation IMP--
    GO:0022904respiratory electron transport chain TAS--
    GO:0044281small molecule metabolic process TAS--


    NDUFAB1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NDUFAB1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NDUFAB1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDUFAB1

    9 HMDB Compounds for NDUFAB1    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Pantetheine 4'-phosphate4'-Phosphopantetheine (see all 8)2226-71-3--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFAB1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    9 Novoseek chemical compound relationships for NDUFAB1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4'-phosphopantetheine 92.4 9 9070424 (2), 16342318 (1), 9485401 (1), 17825260 (1) (see all 5)
    succinate 52.2 3 7805150 (1), 2151077 (1), 1838890 (1)
    lactate 44.2 4 7805150 (1), 19086824 (1), 9192707 (1), 11281253 (1)
    acyl-coa 42 1 14624579 (1)
    aspartate 28.3 2 11281253 (1), 15125998 (1)
    fatty acid 27.2 2 10671542 (1), 19221180 (1)
    alanine 21.7 2 11281253 (1), 15125998 (1)
    glycogen 19.3 1 9342637 (1)
    iron 0 1 9342637 (1)

    Search CenterWatch for drugs/clinical trials and news about NDUFAB1 / ACPM 

    Transcripts
    for NDUFAB1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NDUFAB1 gene: 
    NM_005003.2  

    Unigene Cluster for NDUFAB1:

    NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa
    Hs.189716  [show with all ESTs]
    Unigene Representative Sequence: BQ646109
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000007516(uc002dlw.3) ENST00000562133 ENST00000484769 ENST00000570319
    ENST00000567761

    miRNA
    Products:             		 OriGene 3'-UTR Clone: NDUFAB1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDUFAB1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NDUFAB1:
    hsa-miR-300 hsa-miR-381
    SwitchGear 3'UTR luciferase reporter plasmid: NDUFAB1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NDUFAB1 (see all 7)
    OriGene shRNA RFP: NDUFAB1
    OriGene siRNA: NDUFAB1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFAB1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFAB1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFAB1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NDUFAB1 (NM_005003)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFAB1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFAB1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFAB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFAB1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFAB1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFAB1

    Additional cDNA sequence: 

    AF087660.1 AK311877.1 BC058920.1 EF036489.1 EF036490.1 

    10 DOTS entries:

    DT.417703  DT.91764811  DT.95160156  DT.91764814  DT.40269861  DT.91764813  DT.91810965  DT.95160155 
    DT.91747255  DT.97822119 

    24/413 AceView cDNA sequences (see all 413):

    W30783 AW044220 AA833995 BQ064876 AW139387 AW512267 BM272330 AA878640 
    BI908600 AI160021 BU790266 BU790232 AA831482 AA152029 BU538215 BF057580 
    AA618021 AW007505 AW573186 AW519022 BM764353 BE048186 BQ057195 AI598144 

    GeneLoc Exon Structure


    Expression
    for NDUFAB1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDUFAB1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGACGAAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NDUFAB1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NDUFAB1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDUFAB1

    SOURCE GeneReport for Unigene cluster: Hs.189716
        SABiosciences Expression via Pathway-Focused PCR Array including NDUFAB1: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFAB1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFAB1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFAB1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFAB1
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NDUFAB1

    Orthologs
    for NDUFAB1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for NDUFAB1 gene from 10/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ndufab11 , 5 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, more1, 5 86.32(n)1
    85.9(a)1    		   7 (65.38 cM)5
    703161  NM_028177.31  NP_082453.21 
     1220854035 
    chicken
    (Gallus gallus)    		 Aves NDUFAB11 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, more 70.37(n)
    72.92(a)    		   416571  XM_414872.3  XP_414872.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NDUFAB16
    		 --
    		 77(a)
    		 1 ↔ 1
    		 GL343883.1(133308-134100)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.32342 Xenopus laevis transcribed sequence with weak similarity more 78.33(n)    AW645237.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufd99d012 Transcribed sequence with weak similarity to protein more 76.08(n)    BI896660.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mtacp13 NADH dehydrogenase (ubiquinone) 72(a)   3 61F6   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y56A3A.196
    F37C12.36
    		 Acyl carrier protein
    		 45(a)
    29(a)
    		 many → 1
    many → 1
    		 III(11915046-11915614)
    III(7180668-7182011)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MTACP16
    mtACP26
    (see all 8)    		 acyl carrier protein 1
    NADH dehydrogenase (ubiquinone) 1 alpha/beta subco...
    (see all 8)    		 35(a)
    35(a)
    (see all 8)    		 many → 1
    many → 1
    (see all 8)    		 2(18414251-18415303)
    1(24248828-24250421)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 9)    		 acyl carrier protein, putative, expressed
    (see all 9)    		 39(a)
    34(a)
    (see all 9)    		 many → 1
    many → 1
    (see all 9)    		 5(18130150-18132720)
    7(6797981-6798908)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria acpP6
    		 acyl carrier protein (ACP)
    		 40(a)
    		 1 ↔ 1
    		 Chromosome(1150838-1151074)


    ENSEMBL Gene Tree for NDUFAB1 (if available)
    TreeFam Gene Tree for NDUFAB1 (if available) 

    Paralogs
    for NDUFAB1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDUFAB1 gene

    NDUFAB1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NDUFAB1
    PGOHUM00000243665


    Genomic Variants
    for NDUFAB1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/356 NCBI SNPs in NDUFAB1 are shown (see all 356)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1125780471,2
    		C,--23591857(+) GTTATT/CTACAT 1 -- int13Minor allele frequency- C:0.03NA WA 240
    rs786331631,2
    		C,--23591944(+) GTTTGA/TTGTGT 1 -- int12Minor allele frequency- T:0.03NA 122
    rs1467510211,2
    		--23591972(+) CTTCCA/CGGAGG 1 -- int10--------
    rs1404463241,2
    		--23591983(+) AAAGAC/GAGCCT 1 -- int10--------
    rs1456357771,2
    		--23592067(+) TGATAC/TCAGCT 1 -- int10--------
    rs1381797511,2
    		--23592140(+) TTTCCA/CTGAAT 1 -- int10--------
    rs1133514561,2
    		--23592308(+) CATCAC/TTGAAA 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1136214991,2
    		--23592394(+) TCCATC/TAGAAT 1 -- ut311Minor allele frequency- T:0.50CSA 2
    rs32113361,2
    		C--23592429(-) CACATT/GTTGGC 1 -- ut311Minor allele frequency- G:0.00NA 2
    rs1837016291,2
    		--23592577(+) AAATGA/CAGCCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for NDUFAB1 (23592323 - 23607677 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NDUFAB1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFAB1
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFAB1

    Disorders / Diseases
    for NDUFAB1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NDUFAB1 for disorders           About GeneDecksing

    OMIM gene information: 603836    OMIM disorders: --

    10 diseases for NDUFAB1:    About MalaCards
    hcl-v    bowen-conradi syndrome    cystic fibrosis    mastitis
    huntington's disease    parkinson's disease    fibrosis    tuberculosis
    malaria    carcinoma

    1 Novoseek disease relationship for NDUFAB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 7805150 (1)

    Human Genome Epidemiology (HuGE) Navigator: NDUFAB1 (5 documents)

    Export disorders for NDUFAB1 gene to outside databases

    Publications
    for NDUFAB1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDUFAB1 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with NDUFAB1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2, 3 Loeffen J.L....Smeitink J.A. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
    4. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1, 2 Loftus B.J.... Adams M.D. (1999)
    5. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PubMed id 9763677)1, 3 Emahazion T....Brookes A.J. (1998)
    6. Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death. (PubMed id 19221180)1, 9 Feng D....Smith S. (2009)
    7. The human nuclear-encoded acyl carrier subunit (NDUFAB1) of the mitochondrial complex I in human pathology. (PubMed id 10234612)1, 9 Triepels R....van den Heuvel L. (1999)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)

    External Searches for NDUFAB1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NDUFAB1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4706 HGNC: 7694 AceView: NDUFAB1 Ensembl:ENSG00000004779 euGenes: HUgn4706
    ECgene: NDUFAB1 Kegg: 4706 H-InvDB: NDUFAB1

    Other Databases showing NDUFAB1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NDUFAB1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDUFAB1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NDUFAB1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NDUFAB1 gene:
    Search GeneIP for patents involving NDUFAB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NDUFAB1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NDUFAB1   OriGene shRNA RFP for NDUFAB1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NDUFAB1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFAB1  
     OriGene Protein Over-expression Lysate for NDUFAB1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NDUFAB1   OriGene 3'-UTR Clone for NDUFAB1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFAB1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFAB1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for NDUFAB1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NDUFAB1   OriGene Custom Protein Services for NDUFAB1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFAB1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFAB1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFAB1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFAB1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFAB1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFAB1
     GenScript Custom Purified and Recombinant Proteins Services for NDUFAB1 GenScript cDNA clones with any tag delivered in your preferred vector for NDUFAB1
     GenScript Custom Assay Services for NDUFAB1 GenScript Custom Superior Antibodies Services for NDUFAB1
     GenScript Custom overexpressing Cell Line Services for NDUFAB1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NDUFAB1 promoter
     Search Chromatin IP Primers for NDUFAB1
     RT2 qPCR Primer Assay in human, mouse, rat NDUFAB1
     Search GNC Networks for NDUFAB1
     SABiosciences PCR Arrays including human, mouse, rat NDUFAB1
     Search Tocris compounds for NDUFAB1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NDUFAB1 antibodies
     NDUFAB1 proteins
     NDUFAB1 lysates
     Search for Antibodies for NDUFAB1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NDUFAB1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NDUFAB1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NDUFAB1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NDUFAB1
     SwitchGear 3'UTR luciferase reporter plasmids for NDUFAB1
     SwitchGear Promoter luciferase reporter plasmids for NDUFAB1
     ThermoFisher Antibodies for NDUFAB1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFAB1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NDUFAB1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4