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Aliases for NDUFAB1 Gene

Aliases for NDUFAB1 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit AB1 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1, Alpha/Beta Subcomplex, 1, 8kDa 2 3
  • NADH-Ubiquinone Oxidoreductase 9.6 KDa Subunit 3 4
  • Complex I SDAP Subunit 2 3
  • CI-SDAP 3 4
  • ACP 3 4
  • NADH Dehydrogenase (Ubiquinone) 1, Alpha/Beta Subcomplex, 1 (8kD, SDAP) 2
  • NADH:Ubiquinone Oxidoreductase SDAP Subunit 3
  • Mitochondrial Acyl Carrier Protein 3
  • Acyl Carrier Protein 2
  • Mitochondrial 2
  • FASN2A 3
  • SDAP 3

External Ids for NDUFAB1 Gene

Previous GeneCards Identifiers for NDUFAB1 Gene

  • GC16M023000
  • GC16M023680
  • GC16M023519
  • GC16M023558
  • GC16M023499
  • GC16M021682

Summaries for NDUFAB1 Gene

GeneCards Summary for NDUFAB1 Gene

NDUFAB1 (NADH:Ubiquinone Oxidoreductase Subunit AB1) is a Protein Coding gene. Diseases associated with NDUFAB1 include cerebral palsy, ataxic, autosomal recessive and prostate adenoid cystic carcinoma. Among its related pathways are Metabolism and Viral mRNA Translation. GO annotations related to this gene include calcium ion binding and fatty acid binding.

UniProtKB/Swiss-Prot for NDUFAB1 Gene

  • Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFAB1 Gene

Genomics for NDUFAB1 Gene

Regulatory Elements for NDUFAB1 Gene

Promoters for NDUFAB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDUFAB1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDUFAB1 Gene

Chromosome:
16
Start:
23,581,002 bp from pter
End:
23,596,356 bp from pter
Size:
15,355 bases
Orientation:
Minus strand

Genomic View for NDUFAB1 Gene

Genes around NDUFAB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFAB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFAB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFAB1 Gene

Proteins for NDUFAB1 Gene

  • Protein details for NDUFAB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14561-ACPM_HUMAN
    Recommended name:
    Acyl carrier protein, mitochondrial
    Protein Accession:
    O14561
    Secondary Accessions:
    • B2R4M1
    • Q9UNV1

    Protein attributes for NDUFAB1 Gene

    Size:
    156 amino acids
    Molecular mass:
    17417 Da
    Quaternary structure:
    • Mammalian complex I is composed of 45 different subunits.
    SequenceCaution:
    • Sequence=AAC05814.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NDUFAB1 Gene

neXtProt entry for NDUFAB1 Gene

Proteomics data for NDUFAB1 Gene at MOPED

Post-translational modifications for NDUFAB1 Gene

  • Ubiquitination at Lys 88 and Lys 97
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFAB1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for NDUFAB1
  • Santa Cruz Biotechnology (SCBT) Antibodies for NDUFAB1

No data available for DME Specific Peptides for NDUFAB1 Gene

Domains & Families for NDUFAB1 Gene

Protein Domains for NDUFAB1 Gene

Suggested Antigen Peptide Sequences for NDUFAB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14561

UniProtKB/Swiss-Prot:

ACPM_HUMAN :
  • Contains 1 acyl carrier domain.
Domain:
  • Contains 1 acyl carrier domain.
genes like me logo Genes that share domains with NDUFAB1: view

Function for NDUFAB1 Gene

Molecular function for NDUFAB1 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),8kDa,component alpha/beta 1,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity).

Gene Ontology (GO) - Molecular Function for NDUFAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005504 fatty acid binding ISS --
genes like me logo Genes that share ontologies with NDUFAB1: view
genes like me logo Genes that share phenotypes with NDUFAB1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NDUFAB1

CRISPR Products

miRNA for NDUFAB1 Gene

miRTarBase miRNAs that target NDUFAB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFAB1 Gene

Localization for NDUFAB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFAB1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFAB1 Gene COMPARTMENTS Subcellular localization image for NDUFAB1 gene
Compartment Confidence
mitochondrion 5
chloroplast 2
cytosol 2
lysosome 2
vacuole 2
endoplasmic reticulum 1
extracellular 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NDUFAB1 Gene

Pathways & Interactions for NDUFAB1 Gene

genes like me logo Genes that share pathways with NDUFAB1: view

Interacting Proteins for NDUFAB1 Gene

Gene Ontology (GO) - Biological Process for NDUFAB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
GO:0009249 protein lipoylation IMP 21846720
GO:0046487 glyoxylate metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFAB1: view

No data available for SIGNOR curated interactions for NDUFAB1 Gene

Drugs & Compounds for NDUFAB1 Gene

(7) Drugs for NDUFAB1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(11) Additional Compounds for NDUFAB1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Pantetheine 4'-phosphate
  • 4'-Phosphopantetheine
  • 4'-Phosphopantotheine
  • D-Pantetheine 4'-phosphate
  • Pantetheine 4'-phosphate
  • Pantotheine-4'-phosphate
2226-71-3
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFAB1: view

Transcripts for NDUFAB1 Gene

Unigene Clusters for NDUFAB1 Gene

NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFAB1 Gene

No ASD Table

Relevant External Links for NDUFAB1 Gene

GeneLoc Exon Structure for
NDUFAB1
ECgene alternative splicing isoforms for
NDUFAB1

Expression for NDUFAB1 Gene

mRNA expression in normal human tissues for NDUFAB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFAB1 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.7) and Heart - Atrial Appendage (x4.2).

Protein differential expression in normal tissues from HIPED for NDUFAB1 Gene

This gene is overexpressed in Brain (7.8) and Hair follicle (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFAB1 Gene



SOURCE GeneReport for Unigene cluster for NDUFAB1 Gene Hs.189716

genes like me logo Genes that share expression patterns with NDUFAB1: view

Protein tissue co-expression partners for NDUFAB1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NDUFAB1 Gene

Orthologs for NDUFAB1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NDUFAB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFAB1 35
  • 99.57 (n)
  • 100 (a)
NDUFAB1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFAB1 36
  • 87 (a)
OneToOne
NDUFAB1 35
  • 89.32 (n)
  • 87.18 (a)
dog
(Canis familiaris)
Mammalia NDUFAB1 35
  • 87.45 (n)
  • 87.01 (a)
-- 36
  • 80 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ndufab1 16
Ndufab1 36
  • 86 (a)
OneToOne
Ndufab1 35
  • 86.32 (n)
  • 85.9 (a)
oppossum
(Monodelphis domestica)
Mammalia NDUFAB1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFAB1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufab1 35
  • 85.9 (n)
  • 86.54 (a)
chicken
(Gallus gallus)
Aves NDUFAB1 36
  • 67 (a)
OneToOne
NDUFAB1 35
  • 71.43 (n)
  • 75 (a)
lizard
(Anolis carolinensis)
Reptilia NDUFAB1 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3234 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufab1 35
  • 67.57 (n)
  • 73.65 (a)
Str.5864 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10001 35
zebrafish
(Danio rerio)
Actinopterygii ndufab1a 36
  • 57 (a)
OneToMany
ndufab1b 36
  • 63 (a)
OneToMany
ndufab1b 35
  • 64.64 (n)
  • 65.54 (a)
wufd99d01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010464 35
  • 64.18 (n)
  • 69.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta mtacp1 37
  • 72 (a)
mtacp1 36
  • 43 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y56A3A.19 35
  • 55.38 (n)
  • 54.62 (a)
Y56A3A.19 36
  • 52 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACP1 36
  • 34 (a)
OneToOne
ACP1 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4686 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5076 36
  • 49 (a)
OneToOne
Species with no ortholog for NDUFAB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFAB1 Gene

ENSEMBL:
Gene Tree for NDUFAB1 (if available)
TreeFam:
Gene Tree for NDUFAB1 (if available)

Paralogs for NDUFAB1 Gene

Pseudogenes.org Pseudogenes for NDUFAB1 Gene

genes like me logo Genes that share paralogs with NDUFAB1: view

No data available for Paralogs for NDUFAB1 Gene

Variants for NDUFAB1 Gene

Sequence variations from dbSNP and Humsavar for NDUFAB1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs380618 -- 23,594,952(-) TTTCT(A/G)AGTTC intron-variant
rs443707 -- 23,586,867(-) AATTC(A/G)AGACC intron-variant
rs457194 -- 23,586,133(-) CTGAC(C/T)AACAT intron-variant
rs460186 -- 23,596,571(-) TTAAA(C/T)AGATG upstream-variant-2KB
rs461494 -- 23,597,128(-) GTGTG(G/T)GGGAG upstream-variant-2KB

Variation tolerance for NDUFAB1 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFAB1 Gene

HapMap Linkage Disequilibrium report
NDUFAB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NDUFAB1 Gene

Disorders for NDUFAB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for NDUFAB1 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
cerebral palsy, ataxic, autosomal recessive
  • ataxic cerebral palsy
prostate adenoid cystic carcinoma
  • adenoid cystic carcinoma of prostate
bowen-conradi syndrome
  • bowen hutterite syndrome
myofascial pain syndrome
  • myofascial pain dysfunction syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NDUFAB1

Genetic Association Database (GAD)
NDUFAB1
Human Genome Epidemiology (HuGE) Navigator
NDUFAB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFAB1
genes like me logo Genes that share disorders with NDUFAB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDUFAB1 Gene

Publications for NDUFAB1 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 67
  2. Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death. (PMID: 19221180) Feng D. … Smith S. (J. Biol. Chem. 2009) 3 23
  3. The human nuclear-encoded acyl carrier subunit (NDUFAB1) of the mitochondrial complex I in human pathology. (PMID: 10234612) Triepels R. … van den Heuvel L. (J. Inherit. Metab. Dis. 1999) 3 23
  4. Intron based radiation hybrid mapping of 15 complex I genes of the human electron transport chain. (PMID: 9763677) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for NDUFAB1 Gene

Sources for NDUFAB1 Gene

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