NDUFA7 Gene
protein-coding GIFtS: 53
GCID: GC19M008376
|
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NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa(Previous names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (14.5kD,...)
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Aliases
for NDUFA7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 7, 14.5kDa1 2 | | NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 7 (14.5kD, B14.5a)1 | | B14.5a1 2 | | Complex I B14.5a Subunit2 | | CI-B14.5a2 3 | | NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 72 | | NADH-Ubiquinone Oxidoreductase Subunit B14.5a2 3 | | Complex I-B14.5a3 |
Export aliases for NDUFA7 gene to outside databasesPrevious GC identifers: GC19P008156 GC19M008466 GC19M008268 GC19M008283 GC19M008284 GC19M008285 GC19M008286 GC19M008030 |
Summaries
for NDUFA7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NDUFA7:
This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located inthe inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain.(provided by RefSeq, Mar 2011)
UniProtKB/Swiss-Prot: NDUA7_HUMAN, O95182Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
|
Genomic Views
for NDUFA7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_077812.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDUFA7 gene promoter:
Bach2 AP-2gamma GATA-2 C/EBPalpha CHOP-10 CREB CP2 deltaCREB c-Myb AP-2alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFA7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFA7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2NDUFA7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M008376: view genomic region
(about GC identifiers)
Start:
|
8,376,234 bp from pter |
End:
|
8,386,280 bp from pter |
Size:
|
10,047 bases |
Orientation:
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minus strand |
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Proteins
for NDUFA7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NDUA7_HUMAN, O95182 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 Size: 113 amino acids; 12551 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Sequence caution: Sequence=AAC99399.1; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for NDUFA7: NX_O95182
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O95182
NDUFA7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004992.2
ENSEMBL proteins: ENSP00000301457 Reactome Protein details: O95182
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NDUFA7 for ontologies About GeneDecksing
NDUFA7 Antibody Products:
Assay Products for NDUFA7: |
Protein
Domains /
Families
for NDUFA7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NDUFA7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O95182ProtoNet protein and cluster: O95182 1 Blocks protein family: IPB009947 NADH:ubiquinone oxidoreductase subunit B14.5a
UniProtKB/Swiss-Prot: NDUA7_HUMAN, O95182Similarity: Belongs to the complex I NDUFA7 subunit family |
Function
for NDUFA7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NDUA7_HUMAN, O95182Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone Genatlas biochemistry entry for NDUFA7:NADH ubiquinone oxidoreductase (Q reductase),14.5kDa,component alpha 7,hydrophobic fraction of the complex Imulti-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFA7
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Synthesis Service for NDUFA7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFA7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
NAS | 9878551 |
NDUFA7 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for NDUFA7:
|
Pathways & Interactions
for NDUFA7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  BioSystems Pathways for NDUFA7
4 
Reactome Pathways for NDUFA7
5 
Kegg Pathways (Kegg details for NDUFA7):
NDUFA7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFA7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/59 Interacting proteins for NDUFA7 (O951822, 3 ENSP000003014574) via UniProtKB, MINT, STRING, and/or I2D (see all 59)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
NAS | 9878551 | | GO:0022904 | respiratory electron transport chain |
TAS | -- | | GO:0044281 | small molecule metabolic process |
TAS | -- |
NDUFA7 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDUFA7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NDUFA7
8 HMDB Compounds for NDUFA7 About this table
1 DrugBank Compound for NDUFA7 About this table
Search CenterWatch for drugs/clinical trials and news about NDUFA7 / NDUA7
|
Transcripts
for NDUFA7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NDUFA7 gene: NM_005001.3 Unigene Cluster for NDUFA7: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa Hs.333427 [show with all ESTs]Unigene Representative Sequence: BM5455181 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000301457(uc002mjm.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFA7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDUFA7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NDUFA7 (NM_005001) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDUFA7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFA7 |
Additional cDNA sequence: AF050637.1 AF054178.1 BC003102.1 BC107892.1 CR456915.1 CR542266.1 16 DOTS entries: DT.99946473 DT.316588 DT.121498037 DT.100822533 DT.92384798 DT.100050789 DT.91748043 DT.100670984 DT.40109229 DT.100822534 DT.100843907 DT.101972516 DT.100822532 DT.95199964 DT.121497978 DT.423237 24/537 AceView cDNA sequences (see all 537): CA487675 BG254913 CR594295 BM453235 CB144349 NM_016579 BG751321 BU194469 BQ012380 AI675995 AW024981 CB141050 BM719394 CF528604 F36270 BC035849 BC036814 BE259764 AA296945 BC066775 BF941035 AI936727 CB108536 AI650757
GeneLoc Exon Structure
|
Expression
for NDUFA7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDUFA7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGTCGCAGA
About this image
See NDUFA7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDUFA7
SOURCE GeneReport for Unigene cluster: Hs.333427
SABiosciences Expression via Pathway-Focused PCR Array including NDUFA7:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDUFA7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFA7 |
Orthologs
for NDUFA7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NDUFA7 gene from 5/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NDUFA71 |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more |
67.55(n)
67.26(a) |
|
420065 XM_418185.3 XP_418185.1 |
lizard
(Anolis carolinensis) |
Reptilia |
NDUFA76 |
-- |
59(a) |
1 → many |
1(149131783-149132133) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.65362 |
Xenopus laevis transcribed sequence with moderate similarity more |
71.26(n) |
|
AW635275.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ndufa71 |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more |
58.01(n)
65.38(a) |
|
445042 NM_001003436.1 NP_001003436.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG36216CG69146 |
-- |
40(a)24(a) |
many ↔ manymany ↔ many |
X(2066561-2067170) 3L(22599469-22600226) |
ENSEMBL Gene Tree for NDUFA7 (if available)
TreeFam Gene Tree for NDUFA7 (if available) |
Paralogs
for NDUFA7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for NDUFA7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NDUFA7 (8376234 - 8386280 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NDUFA7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFA7 |
|
Disorders
/ Diseases
for NDUFA7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDUFA7 for disorders About GeneDecksing
OMIM gene information: 602139
OMIM disorders: --
2  diseases for NDUFA7: About MalaCardshuntington's disease parkinson's disease
Human Genome Epidemiology (HuGE) Navigator: NDUFA7 (4 documents)
Export disorders for NDUFA7 gene to outside databases
|
Publications
for NDUFA7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NDUFA7 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with NDUFA7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2 Loeffen J.L....Smeitink J.A. (1998)
- Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping. (PubMed id 9763676)1, 3 Emahazion T. and Brookes A.J. (1998)
- In situ hybridisation mapping of genomic clones for five human respiratory chain complex I genes. (PubMed id 9345899)1, 9 Dunbar D.R....Brookes A.J. (1997)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for NDUFA7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDUFA7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFA7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFA7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NDUFA7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NDUFA7 gene:
Search GeneIP for patents involving NDUFA7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDUFA7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFA7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDUFA7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFA7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFA7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFA7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFA7 |
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