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Aliases for NDUFA7 Gene

Aliases for NDUFA7 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 7, 14.5kDa 2 3
  • NADH-Ubiquinone Oxidoreductase Subunit B14.5a 3 4
  • Complex I B14.5a Subunit 2 3
  • CI-B14.5a 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 7 (14.5kD, B14.5a) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 7 3
  • Complex I-B14.5a 4
  • B14.5a 3

External Ids for NDUFA7 Gene

Summaries for NDUFA7 Gene

Entrez Gene Summary for NDUFA7 Gene

  • This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]

GeneCards Summary for NDUFA7 Gene

NDUFA7 (NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 7, 14.5kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFA7 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA7 Gene

Genomics for NDUFA7 Gene

Genomic Location for NDUFA7 Gene

Start:
8,308,608 bp from pter
End:
8,321,533 bp from pter
Size:
12,926 bases
Orientation:
Minus strand

Genomic View for NDUFA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA7 Gene

Regulatory Elements for NDUFA7 Gene

Proteins for NDUFA7 Gene

  • Protein details for NDUFA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95182-NDUA7_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
    Protein Accession:
    O95182
    Secondary Accessions:

    Protein attributes for NDUFA7 Gene

    Size:
    113 amino acids
    Molecular mass:
    12551 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.
    SequenceCaution:
    • Sequence=AAC99399.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NDUFA7 Gene

Proteomics data for NDUFA7 Gene at MOPED

Post-translational modifications for NDUFA7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys23

Other Protein References for NDUFA7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFA7 Gene

Domains for NDUFA7 Gene

Gene Families for NDUFA7 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFA7 Gene

UniProtKB/Swiss-Prot:

NDUA7_HUMAN
Family:
  • Belongs to the complex I NDUFA7 subunit family.:
    • O95182
genes like me logo Genes that share domains with NDUFA7: view

Function for NDUFA7 Gene

Molecular function for NDUFA7 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),14.5kDa,component alpha 7,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFA7: view

Phenotypes for NDUFA7 Gene

genes like me logo Genes that share phenotypes with NDUFA7: view

miRNA for NDUFA7 Gene

miRTarBase miRNAs that target NDUFA7

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFA7 Gene

Localization for NDUFA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFA7 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFA7 Gene COMPARTMENTS Subcellular localization image for NDUFA7 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for NDUFA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
genes like me logo Genes that share ontologies with NDUFA7: view

Pathways for NDUFA7 Gene

genes like me logo Genes that share pathways with NDUFA7: view

Gene Ontology (GO) - Biological Process for NDUFA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0042773 ATP synthesis coupled electron transport --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFA7: view

Compounds for NDUFA7 Gene

(8) HMDB Compounds for NDUFA7 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFA7 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFA7: view

Transcripts for NDUFA7 Gene

Unigene Clusters for NDUFA7 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA7 Gene

No ASD Table

Relevant External Links for NDUFA7 Gene

GeneLoc Exon Structure for
NDUFA7
ECgene alternative splicing isoforms for
NDUFA7

Expression for NDUFA7 Gene

mRNA expression in normal human tissues for NDUFA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFA7 Gene

SOURCE GeneReport for Unigene cluster for NDUFA7 Gene Hs.333427

genes like me logo Genes that share expressions with NDUFA7: view

Orthologs for NDUFA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFA7 36
  • 99.12 (n)
  • 100 (a)
NDUFA7 37
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NDUFA7 36
  • 87.91 (n)
  • 88.5 (a)
NDUFA7 37
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 80 (a)
OneToMany
NDUFA7 36
  • 88.2 (n)
  • 85.84 (a)
mouse
(Mus musculus)
Mammalia Ndufa7 36
  • 84.96 (n)
  • 91.15 (a)
Ndufa7 16
Ndufa7 37
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 74 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ndufa7 36
  • 85.42 (n)
  • 91.07 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 64 (a)
OneToMany
NDUFA7 36
  • 68.14 (n)
  • 67.26 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6536 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufa7 36
  • 61.36 (n)
  • 69.91 (a)
zebrafish
(Danio rerio)
Actinopterygii ndufa7 36
  • 58.33 (n)
  • 65.38 (a)
ndufa7 37
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3621 37
  • 40 (a)
ManyToMany
CG6914 37
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4399 37
  • 41 (a)
OneToMany
Species with no ortholog for NDUFA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFA7 Gene

ENSEMBL:
Gene Tree for NDUFA7 (if available)
TreeFam:
Gene Tree for NDUFA7 (if available)

Paralogs for NDUFA7 Gene

Selected SIMAP similar genes for NDUFA7 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NDUFA7: view

No data available for Paralogs for NDUFA7 Gene

Variants for NDUFA7 Gene

Sequence variations from dbSNP and Humsavar for NDUFA7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs561 -- 8,311,547(+) TTTAT(A/G)GGAGG reference, synonymous-codon, nc-transcript-variant
rs2288415 - 8,316,551(-) TGCCC(C/G)CTTCC reference, missense, nc-transcript-variant
rs2913944 -- 8,314,830(+) ATGGC(A/G)TGAAC intron-variant
rs2927706 -- 8,312,067(-) GAGGG(C/T)GGTGC intron-variant
rs2972570 -- 8,316,279(+) atgat(C/T)gcgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFA7 Gene

Variant ID Type Subtype PubMed ID
dgv3718n71 CNV Loss 21882294
nsv2401 CNV Loss 18451855
dgv620e199 CNV Deletion 23128226

Relevant External Links for NDUFA7 Gene

HapMap Linkage Disequilibrium report
NDUFA7

Disorders for NDUFA7 Gene

Relevant External Links for NDUFA7

Genetic Association Database (GAD)
NDUFA7
Human Genome Epidemiology (HuGE) Navigator
NDUFA7
genes like me logo Genes that share disorders with NDUFA7: view

No data available for UniProtKB/Swiss-Prot for NDUFA7 Gene

Publications for NDUFA7 Gene

  1. In situ hybridisation mapping of genomic clones for five human respiratory chain complex I genes. (PMID: 9345899) Dunbar D.R. … Brookes A.J. (Cytogenet. Cell Genet. 1997) 3 23
  2. Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping. (PMID: 9763676) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  3. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4

Products for NDUFA7 Gene

Sources for NDUFA7 Gene

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