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Aliases for NDUFA7 Gene

Aliases for NDUFA7 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit A7 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 7, 14.5kDa 2 3
  • NADH-Ubiquinone Oxidoreductase Subunit B14.5a 3 4
  • Complex I B14.5a Subunit 2 3
  • CI-B14.5a 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 7 (14.5kD, B14.5a) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 7 3
  • Complex I-B14.5a 4
  • B14.5a 3

External Ids for NDUFA7 Gene

Previous GeneCards Identifiers for NDUFA7 Gene

  • GC19P008156
  • GC19M008466
  • GC19M008268
  • GC19M008283
  • GC19M008284
  • GC19M008285
  • GC19M008286
  • GC19M008030
  • GC19M008376

Summaries for NDUFA7 Gene

Entrez Gene Summary for NDUFA7 Gene

  • This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]

GeneCards Summary for NDUFA7 Gene

NDUFA7 (NADH:Ubiquinone Oxidoreductase Subunit A7) is a Protein Coding gene. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. Gene Ontology (GO) annotations related to this gene include NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is ENSG00000167774.

UniProtKB/Swiss-Prot for NDUFA7 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Additional gene information for NDUFA7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA7 Gene

Genomics for NDUFA7 Gene

GeneHancer (GH) Regulatory Elements for NDUFA7 Gene

Promoters and enhancers for NDUFA7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I008319 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.1 -60 3.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RPS28 ENSG00000167774 GC19P008321 NDUFA7 HNRNPM XAB2 ZNF317 ZNF699 ZNF558 MAP2K7
GH19I007394 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.6 +925.8 925830 2.8 PKNOX1 ARID4B SIN3A ZNF48 ETS1 ZNF121 POLR2B GLIS2 E2F8 ELK1 ENSG00000267852 ARHGEF18 TEX45 PEX11G NDUFA7 ENSG00000268861 GC19P007434
GH19I007397 Enhancer 1.1 Ensembl ENCODE 4.6 +922.7 922667 2.7 CLOCK FOXA2 ARID4B SIN3A ZNF48 ETS1 ZNF121 ATF7 RXRA PPARG TEX45 PEX11G NDUFA7 ENSG00000267852 ENSG00000268861 GC19P007434 ARHGEF18
GH19I007368 Enhancer 0.6 Ensembl ENCODE 4.6 +952.5 952493 1.5 FOSL1 USF1 JUND CAMSAP3 ZNF557 NDUFA7 GC19P007378 ARHGEF18 ENSG00000263264
GH19I008306 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 0.4 +13.6 13593 3.3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CD320 RPS28 ZNF558 ELAVL1 HNRNPM XAB2 MAP2K7 ENSG00000269300 ZNF317 ENSG00000167774
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NDUFA7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDUFA7 gene promoter:

Genomic Locations for NDUFA7 Gene

Genomic Locations for NDUFA7 Gene
chr19:8,308,762-8,321,396
(GRCh38/hg38)
Size:
12,635 bases
Orientation:
Minus strand
chr19:8,373,490-8,386,280
(GRCh37/hg19)

Genomic View for NDUFA7 Gene

Genes around NDUFA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA7 Gene

Proteins for NDUFA7 Gene

  • Protein details for NDUFA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95182-NDUA7_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
    Protein Accession:
    O95182

    Protein attributes for NDUFA7 Gene

    Size:
    113 amino acids
    Molecular mass:
    12551 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.
    SequenceCaution:
    • Sequence=AAC99399.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NDUFA7 Gene

neXtProt entry for NDUFA7 Gene

Post-translational modifications for NDUFA7 Gene

Other Protein References for NDUFA7 Gene

No data available for DME Specific Peptides for NDUFA7 Gene

Domains & Families for NDUFA7 Gene

Gene Families for NDUFA7 Gene

Protein Domains for NDUFA7 Gene

Suggested Antigen Peptide Sequences for NDUFA7 Gene

Graphical View of Domain Structure for InterPro Entry

O95182

UniProtKB/Swiss-Prot:

NDUA7_HUMAN :
  • Belongs to the complex I NDUFA7 subunit family.
Family:
  • Belongs to the complex I NDUFA7 subunit family.
genes like me logo Genes that share domains with NDUFA7: view

Function for NDUFA7 Gene

Molecular function for NDUFA7 Gene

GENATLAS Biochemistry:
NADH ubiquinone oxidoreductase (Q reductase),14.5kDa,component alpha 7,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

Gene Ontology (GO) - Molecular Function for NDUFA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS 11402041
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFA7: view
genes like me logo Genes that share phenotypes with NDUFA7: view

Animal Model Products

CRISPR Products

miRNA for NDUFA7 Gene

miRTarBase miRNAs that target NDUFA7

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFA7 Gene

Localization for NDUFA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFA7 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDUFA7 gene
Compartment Confidence
mitochondrion 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NDUFA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0005761 mitochondrial ribosome ISS 11402041
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDUFA7: view

Pathways & Interactions for NDUFA7 Gene

genes like me logo Genes that share pathways with NDUFA7: view

Gene Ontology (GO) - Biological Process for NDUFA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone IBA,TAS --
GO:0032543 mitochondrial translation ISS 11402041
GO:0032981 mitochondrial respiratory chain complex I assembly TAS --
GO:0042773 ATP synthesis coupled electron transport IEA --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NDUFA7: view

No data available for SIGNOR curated interactions for NDUFA7 Gene

Drugs & Compounds for NDUFA7 Gene

(5) Drugs for NDUFA7 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Approved Nutra Target 0
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFA7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFA7: view

Transcripts for NDUFA7 Gene

Unigene Clusters for NDUFA7 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA7 Gene

No ASD Table

Relevant External Links for NDUFA7 Gene

GeneLoc Exon Structure for
NDUFA7
ECgene alternative splicing isoforms for
NDUFA7

Expression for NDUFA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDUFA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFA7 Gene

This gene is overexpressed in Bone (11.2), Heart (8.2), and Frontal cortex (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDUFA7 Gene



Protein tissue co-expression partners for NDUFA7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDUFA7 Gene:

NDUFA7

SOURCE GeneReport for Unigene cluster for NDUFA7 Gene:

Hs.333427

Evidence on tissue expression from TISSUES for NDUFA7 Gene

  • Liver(4.4)
  • Lung(4.4)
  • Blood(4.1)
  • Heart(3)
  • Muscle(2.6)
  • Nervous system(2.4)
  • Kidney(2.1)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with NDUFA7: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDUFA7 Gene

Orthologs for NDUFA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFA7 33 34
  • 99.12 (n)
dog
(Canis familiaris)
Mammalia NDUFA7 33
  • 88.2 (n)
-- 34
  • 80 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NDUFA7 34 33
  • 87.91 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ndufa7 33
  • 85.42 (n)
mouse
(Mus musculus)
Mammalia Ndufa7 33 16 34
  • 84.96 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 74 (a)
OneToMany
chicken
(Gallus gallus)
Aves NDUFA7 33
  • 68.14 (n)
-- 34
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufa7 33
  • 61.36 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6536 33
zebrafish
(Danio rerio)
Actinopterygii ndufa7 33 34
  • 58.33 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3621 34
  • 40 (a)
ManyToMany
CG6914 34
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4399 34
  • 41 (a)
OneToMany
Species where no ortholog for NDUFA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFA7 Gene

ENSEMBL:
Gene Tree for NDUFA7 (if available)
TreeFam:
Gene Tree for NDUFA7 (if available)

Paralogs for NDUFA7 Gene

Paralogs for NDUFA7 Gene

genes like me logo Genes that share paralogs with NDUFA7: view

Variants for NDUFA7 Gene

Sequence variations from dbSNP and Humsavar for NDUFA7 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs786203997 pathogenic, Diamond-Blackfan anemia 15 with mandibulofacial dysostosis 8,321,531(-) A/G upstream_transcript_variant
rs2232773 benign, not specified 8,308,292(-) C/T downstream_transcript_variant
rs2232775 benign, not specified 8,308,268(-) T/C downstream_transcript_variant
rs2232776 benign, not specified 8,308,139(-) C/G/T downstream_transcript_variant
rs1000026642 -- 8,309,461(-) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFA7 Gene

Variant ID Type Subtype PubMed ID
dgv620e199 CNV deletion 23128226
esv3643613 CNV loss 21293372
nsv1160579 CNV deletion 26073780
nsv2401 CNV deletion 18451855

Variation tolerance for NDUFA7 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDUFA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDUFA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFA7 Gene

Disorders for NDUFA7 Gene

Additional Disease Information for NDUFA7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NDUFA7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFA7 Gene

Publications for NDUFA7 Gene

  1. Accessory subunits are integral for assembly and function of human mitochondrial complex I. (PMID: 27626371) Stroud DA … Ryan MT (Nature 2016) 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58
  4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr JM … Deary IJ (Mechanisms of ageing and development 2008) 3 44 58
  5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris SE … Deary IJ (BMC genetics 2007) 3 44 58

Products for NDUFA7 Gene

Sources for NDUFA7 Gene

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