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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDUFA6 Gene

protein-coding   GIFtS: 59
GCID: GC22M042481

NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 6, 14kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (14kD,...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 6, 14kDa1 2     LYR Motif-Containing Protein 62 3
Complex I B14 Subunit1 2     NADH-Ubiquinone Oxidoreductase B14 Subunit2 3
CI-B142 3     NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 6 (14kD, B14)1
LYRM62 3     B142
NADHB142 3     NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 62
Complex I-B142 3     NADH-Ubiquinone Oxidoreductase 1 Alpha Subcomplex, 62

External Ids:    HGNC: 76901   Entrez Gene: 47002   Ensembl: ENSG000001849837   OMIM: 6021385   UniProtKB: P565563   

Export aliases for NDUFA6 gene to outside databases

Previous GC identifers: GC22M039096 GC22M040724 GC22M040806 GC22M040811 GC22M025447


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NDUFA6 Gene: 
NDUFA6 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa) is a protein-coding gene. Diseases associated with NDUFA6 include immunoglobulin alpha deficiency, and 21-hydroxylase deficiency, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NDUA6_HUMAN, P56556
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFA6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDUFA6 gene promoter:
         GR   FOXD3   POU6F1 (c2)   HNF-4alpha2   Evi-1   HNF-4alpha1   GATA-1   AREB6   Cart-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFA6 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDUFA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFA6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.2   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.2

NDUFA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFA6 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M042481:  view genomic region     (about GC identifiers)

Start:
42,481,529 bp from pter      End:
42,486,959 bp from pter
Size:
5,431 bases      Orientation:
minus strand

1 alternative location:
Chr22-,NW_003315971 3,567-8,925     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDUA6_HUMAN, P56556 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6  
Size: 154 amino acids; 17871 Da
Subunit: Mammalian complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Caution: It is uncertain whether Met-1 or Met-27 is the initiator
Sequence caution: Sequence=AAC04267.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAF84563.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAG38151.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW60489.1; Type=Erroneous
initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RE54 O43675 Q6FGW0 Q6IBT8 Q6IC39

Explore the universe of human proteins at neXtProt for NDUFA6: NX_P56556

Explore proteomics data for NDUFA6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P56556

  • NDUFA6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDUFA6 Protein Expression
    REFSEQ proteins: NP_002481.2  
    ENSEMBL proteins: 
     ENSP00000473461   ENSP00000418842   ENSP00000473478  
    Reactome Protein details: P56556
    Human Recombinant Protein Products for NDUFA6: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0031966mitochondrial membrane IDA17209039

    NDUFA6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comI: Mitochondrial respiratory chain complex / Complex I
    LYRM: LYR motif containing

    2 InterPro protein domains:
     IPR008011 Complex1_LYR
     IPR016488 NADH_Ub_cplx-1_asu_su-6

    Graphical View of Domain Structure for InterPro Entry P56556

    ProtoNet protein and cluster: P56556

    1 Blocks protein domain: IPB008011 Complex 1 LYR protein

    UniProtKB/Swiss-Prot: NDUA6_HUMAN, P56556
    Similarity: Belongs to the complex I LYR family


    NDUFA6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUA6_HUMAN, P56556
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Genatlas biochemistry entry for NDUFA6:
    NADH ubiquinone oxidoreductase (Q reductase),14kDa,component alpha 6,hydrophobic fraction of the complex I
    multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    NDUFA6 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDUFA6 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.47
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Alzheimer's disease0.46
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFA6
        Electron Transport Chain
    Oxidative phosphorylation

    4        Reactome Pathways for NDUFA6
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/6         Kegg Pathways  (Kegg details for NDUFA6) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFA6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFA6

    5/20 Interacting proteins for NDUFA6 (P565562, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BAG6P463792, 3MINT-63909 I2D: score=5 
    ENSG00000096155P463792, 3MINT-63909 I2D: score=5 
    ENSG00000227761P463792, 3MINT-63909 I2D: score=5 
    ENSG00000228760P463792, 3MINT-63909 I2D: score=5 
    ENSG00000229524P463792, 3MINT-63909 I2D: score=5 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0006979response to oxidative stress IDA12857734
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NDUFA6 (NDUA6)

    8 HMDB Compounds for NDUFA6    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFA6    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about NDUFA6 / NDUA6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDUFA6 gene: 
    NM_002490.3  

    Unigene Cluster for NDUFA6:

    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa
    Hs.274416  [show with all ESTs]
    Unigene Representative Sequence: NM_002490
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602404 ENST00000498737(uc003bcb.3) ENST00000470753

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    Additional mRNA sequence: 

    AF047182.1 AK291874.1 AK316562.1 BC002772.1 CR456529.1 CR456714.1 CR541997.1 

    16 DOTS entries:

    DT.91942773  DT.317941  DT.91965491  DT.91995455  DT.120667061  DT.40123356  DT.120667023  DT.92055462 
    DT.100822440  DT.101987219  DT.91994536  DT.99991968  DT.120667072  DT.95241609  DT.97847080  DT.95241578 

    24/386 AceView cDNA sequences (see all 386):

    BM704473 BE274309 AI382147 AA331460 BU553209 AA836976 CR620155 AI581839 
    BU160089 AI334121 BU188710 BM978070 CN480747 BQ668782 AI174763 AI350860 
    CB135867 CD367827 AA565037 C21293 AI340207 CA427429 BQ883303 BM983268 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA6    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
    SP1:                    -                           
    SP2:              -     -                           
    SP3:                                                


    ECgene alternative splicing isoforms for NDUFA6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDUFA6 expression in normal human tissues (normalized intensities)      NDUFA6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NDUFA6 Expression
    About this image


    NDUFA6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             brain/hindbrain   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium   

    See NDUFA6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDUFA6

    SOURCE GeneReport for Unigene cluster: Hs.274416
        SABiosciences Expression via Pathway-Focused PCR Array including NDUFA6: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NDUFA6 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufa61 , 5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more1, 5 87.93(n)1
    88.19(a)1
      15 (38.56 cM)5
    671301  NM_025987.31  NP_080263.11 
     823501395 
    chicken
    (Gallus gallus)
    Aves NDUFA61 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more 77.98(n)
    84.82(a)
      427897  XM_425471.3  XP_425471.2 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFA66
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex...
    76(a)
    1 ↔ 1
    5(27098391-27101609)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.101862 Xenopus laevis transcribed sequence with moderate similarity more 71.61(n)    48060568 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc567172 similar to NADH dehydrogenase (ubiquinone) 1 alpha more 77.55(n)   393943  BC042332.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77121 , 3 NADH dehydrogenase (ubiquinone)3
    CG77121
    48(a)3
    56.01(n)1
    50(a)1
      47C33
    361591  NM_136785.21  NP_610629.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nuo-36
    Protein NUO-3, isoform b
    31(a)
    1 ↔ 1
    IV(14796417-14797514)


    ENSEMBL Gene Tree for NDUFA6 (if available)
    TreeFam Gene Tree for NDUFA6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/102 SNPs in NDUFA6 are shown (see all 102)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0144834
    ----see VAR_0144832 A V mis40--------
    rs72889801,2
    C,F--42481032(+) aacacT/Cttggg 1 -- ds50011Minor allele frequency- C:0.07WA 118
    rs1483651141,2
    C--42481042(+) GAGGCA/GGAGGC 1 -- ds50010--------
    rs1407168751,2
    --42481088(+) CCTGGC/GCGCGG 1 -- ds50010--------
    rs1903764991,2
    --42481122(+) GGCCAC/TGGCGG 1 -- ds50010--------
    rs1147672891,2
    C,F--42481123(+) GCCACG/AGCGGG 1 -- ds50011Minor allele frequency- A:0.09WA 118
    rs1829733781,2
    --42481221(+) TGGTGA/GTCCAT 1 -- ds50010--------
    rs57585741,2
    C,F,A--42481400(+) gagacC/Gccatc 1 -- ds500110Minor allele frequency- G:0.36WA NA CSA EA 370
    rs2014149691,2
    C--42481410(+) TCTCT-/TTTAAA 1 -- ds50010--------
    rs72895921,2
    C,F,A--42481412(+) ctattT/Aaaaaa 1 -- ds50012Minor allele frequency- A:0.50WA NA 4

    HapMap Linkage Disequilibrium report for NDUFA6 (42481529 - 42486959 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NDUFA6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508737CNV Insertion20534489
    dgv4981n71CNV Loss21882294
    nsv834210CNV Loss17160897
    nsv915161CNV Loss21882294


    Human Gene Mutation Database (HGMD): NDUFA6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFA6
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFA6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602138    OMIM disorders: --

    7 diseases for NDUFA6:    About MalaCards
    immunoglobulin alpha deficiency    21-hydroxylase deficiency    hemochromatosis    polycystic ovary syndrome
    huntington's disease    parkinson's disease    alzheimer's disease


    NDUFA6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NDUFA6
    Human Genome Epidemiology (HuGE) Navigator: NDUFA6 (5 documents)

    Export disorders for NDUFA6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDUFA6 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with NDUFA6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PubMed id 9425316)1, 2, 3 Ton C....Liew C.C. (1997)
    2. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage he ad and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (2010)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    5. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    9. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4700 HGNC: 7690 AceView: NDUFA6 Ensembl:ENSG00000184983 euGenes: HUgn4700
    ECgene: NDUFA6 Kegg: 4700 H-InvDB: NDUFA6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDUFA6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDUFA6 gene:
    Search GeneIP for patents involving NDUFA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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