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Aliases for NDUFA6 Gene

Aliases for NDUFA6 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 6, 14kDa 2 3
  • NADH-Ubiquinone Oxidoreductase B14 Subunit 3 4
  • LYR Motif-Containing Protein 6 3 4
  • Complex I B14 Subunit 2 3
  • Complex I-B14 3 4
  • NADHB14 3 4
  • CI-B14 3 4
  • LYRM6 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 6 (14kD, B14) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 6 3
  • NADH-Ubiquinone Oxidoreductase 1 Alpha Subcomplex, 6 3
  • B14 3

External Ids for NDUFA6 Gene

Summaries for NDUFA6 Gene

GeneCards Summary for NDUFA6 Gene

NDUFA6 (NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 6, 14kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFA6 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFA6 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA6 Gene

Genomics for NDUFA6 Gene

Genomic Location for NDUFA6 Gene

Start:
42,085,525 bp from pter
End:
42,090,955 bp from pter
Size:
5,431 bases
Orientation:
Minus strand

Genomic View for NDUFA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA6 Gene

Regulatory Elements for NDUFA6 Gene

Proteins for NDUFA6 Gene

  • Protein details for NDUFA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56556-NDUA6_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6
    Protein Accession:
    P56556
    Secondary Accessions:
    • B2RE54
    • O43675
    • Q6FGW0
    • Q6IBT8
    • Q6IC39

    Protein attributes for NDUFA6 Gene

    Size:
    154 amino acids
    Molecular mass:
    17871 Da
    Quaternary structure:
    • Mammalian complex I is composed of 45 different subunits.
    SequenceCaution:
    • Sequence=AAC04267.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF84563.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG38151.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW60489.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NDUFA6 Gene

Proteomics data for NDUFA6 Gene at MOPED

Post-translational modifications for NDUFA6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys44, Lys142, and Lys147

Other Protein References for NDUFA6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFA6 Gene

Domains for NDUFA6 Gene

Gene Families for NDUFA6 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I
  • LYRM :LYR motif containing

Protein Domains for NDUFA6 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NDUA6_HUMAN
Family:
  • Belongs to the complex I LYR family.:
    • P56556
genes like me logo Genes that share domains with NDUFA6: view

Function for NDUFA6 Gene

Molecular function for NDUFA6 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase (Q reductase),14kDa,component alpha 6,hydrophobic fraction of the complex I multi-subunit enzyme of the oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFA6: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NDUFA6 Gene

Localization for NDUFA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFA6 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFA6 Gene COMPARTMENTS Subcellular localization image for NDUFA6 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for NDUFA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0031966 mitochondrial membrane IDA 17209039
genes like me logo Genes that share ontologies with NDUFA6: view

Pathways for NDUFA6 Gene

genes like me logo Genes that share pathways with NDUFA6: view

Gene Ontology (GO) - Biological Process for NDUFA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0006979 response to oxidative stress IDA 12857734
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFA6: view

Compounds for NDUFA6 Gene

(8) HMDB Compounds for NDUFA6 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFA6 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFA6: view

Transcripts for NDUFA6 Gene

mRNA/cDNA for NDUFA6 Gene

Unigene Clusters for NDUFA6 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for NDUFA6 Gene

GeneLoc Exon Structure for
NDUFA6
ECgene alternative splicing isoforms for
NDUFA6

Expression for NDUFA6 Gene

mRNA expression in normal human tissues for NDUFA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDUFA6 Gene

This gene is overexpressed in Heart - Left Ventricle (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NDUFA6 Gene

SOURCE GeneReport for Unigene cluster for NDUFA6 Gene Hs.274416

genes like me logo Genes that share expressions with NDUFA6: view

Orthologs for NDUFA6 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFA6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFA6 36
  • 99.48 (n)
  • 100 (a)
NDUFA6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFA6 36
  • 90.89 (n)
  • 90.62 (a)
NDUFA6 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFA6 36
  • 86.39 (n)
  • 83.67 (a)
NDUFA6 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufa6 36
  • 87.93 (n)
  • 88.19 (a)
Ndufa6 16
Ndufa6 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFA6 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFA6 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufa6 36
  • 87.66 (n)
  • 88.19 (a)
chicken
(Gallus gallus)
Aves NDUFA6 36
  • 77.98 (n)
  • 84.82 (a)
lizard
(Anolis carolinensis)
Reptilia NDUFA6 37
  • 75 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.10186 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufa6 36
  • 69.03 (n)
  • 78.74 (a)
Str.2078 36
zebrafish
(Danio rerio)
Actinopterygii ndufa6 36
  • 69.01 (n)
  • 71.87 (a)
ndufa6 37
  • 73 (a)
OneToOne
zgc56717 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012533 36
  • 56.47 (n)
  • 46.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7712 36
  • 56.01 (n)
  • 50 (a)
CG7712 37
  • 46 (a)
OneToOne
CG7712 38
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4860 37
  • 41 (a)
OneToOne
Species with no ortholog for NDUFA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFA6 Gene

ENSEMBL:
Gene Tree for NDUFA6 (if available)
TreeFam:
Gene Tree for NDUFA6 (if available)

Paralogs for NDUFA6 Gene

No data available for Paralogs for NDUFA6 Gene

Variants for NDUFA6 Gene

Sequence variations from dbSNP and Humsavar for NDUFA6 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs7245 -- 42,085,845(+) ACACT(A/G)AAGTG utr-variant-3-prime
rs1801381 -- 42,086,089(-) TGATG(A/G)ACCAA utr-variant-3-prime
rs4147641 -- 42,086,498(-) AAAGT(C/G)TCAGA intron-variant
rs5758574 -- 42,085,396(+) gagac(C/G)ccatc downstream-variant-500B
rs5758575 -- 42,088,552(+) cgttt(C/T)tacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFA6 Gene

Variant ID Type Subtype PubMed ID
nsv508737 CNV Insertion 20534489
nsv834210 CNV Loss 17160897
nsv915161 CNV Loss 21882294
dgv4981n71 CNV Loss 21882294

Relevant External Links for NDUFA6 Gene

HapMap Linkage Disequilibrium report
NDUFA6
Human Gene Mutation Database (HGMD)
NDUFA6

Disorders for NDUFA6 Gene

Relevant External Links for NDUFA6

Genetic Association Database (GAD)
NDUFA6
Human Genome Epidemiology (HuGE) Navigator
NDUFA6
genes like me logo Genes that share disorders with NDUFA6: view

No data available for UniProtKB/Swiss-Prot for NDUFA6 Gene

Publications for NDUFA6 Gene

  1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PMID: 9425316) Ton C. … Liew C.-C. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  2. Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping. (PMID: 9763676) Emahazion T. … Brookes A.J. (Cytogenet. Cell Genet. 1998) 2 3
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 3 4
  4. In situ hybridisation mapping of genomic clones for five human respiratory chain complex I genes. (PMID: 9345899) Dunbar D.R. … Brookes A.J. (Cytogenet. Cell Genet. 1997) 3 23
  5. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4

Products for NDUFA6 Gene

Sources for NDUFA6 Gene

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