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Aliases for NDUFA4L2 Gene

Aliases for NDUFA4L2 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4-Like 2 2 3 5
  • NADH-Ubiquinone Oxidoreductase MLRQ Subunit Homolog 3 4
  • NUOMS 3 4
  • NADH:Ubiquinone Oxidoreductase MLRQ Subunit Homolog 3

External Ids for NDUFA4L2 Gene

Previous GeneCards Identifiers for NDUFA4L2 Gene

  • GC12M055915
  • GC12M057629
  • GC12M054667

Summaries for NDUFA4L2 Gene

GeneCards Summary for NDUFA4L2 Gene

NDUFA4L2 (NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4-Like 2) is a Protein Coding gene. Among its related pathways are Metabolism and Alzheimers disease. An important paralog of this gene is NDUFA4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA4L2 Gene

Genomics for NDUFA4L2 Gene

Regulatory Elements for NDUFA4L2 Gene

Promoters for NDUFA4L2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDUFA4L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDUFA4L2 Gene

Chromosome:
12
Start:
57,234,903 bp from pter
End:
57,240,762 bp from pter
Size:
5,860 bases
Orientation:
Minus strand

Genomic View for NDUFA4L2 Gene

Genes around NDUFA4L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFA4L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFA4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA4L2 Gene

Proteins for NDUFA4L2 Gene

  • Protein details for NDUFA4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX3-NUA4L_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
    Protein Accession:
    Q9NRX3
    Secondary Accessions:
    • Q6IAH9

    Protein attributes for NDUFA4L2 Gene

    Size:
    87 amino acids
    Molecular mass:
    9966 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NDUFA4L2 Gene

Proteomics data for NDUFA4L2 Gene at MOPED

Post-translational modifications for NDUFA4L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFA4L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFA4L2 Gene

Domains & Families for NDUFA4L2 Gene

Protein Domains for NDUFA4L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFA4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX3

UniProtKB/Swiss-Prot:

NUA4L_HUMAN :
  • Belongs to the complex I NDUFA4 subunit family.
Family:
  • Belongs to the complex I NDUFA4 subunit family.
genes like me logo Genes that share domains with NDUFA4L2: view

No data available for Gene Families for NDUFA4L2 Gene

Function for NDUFA4L2 Gene

genes like me logo Genes that share phenotypes with NDUFA4L2: view

Animal Model Products

CRISPR Products

miRNA for NDUFA4L2 Gene

miRTarBase miRNAs that target NDUFA4L2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFA4L2 Gene

Localization for NDUFA4L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFA4L2 Gene COMPARTMENTS Subcellular localization image for NDUFA4L2 gene
Compartment Confidence
mitochondrion 4
extracellular 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NDUFA4L2 Gene

Pathways & Interactions for NDUFA4L2 Gene

genes like me logo Genes that share pathways with NDUFA4L2: view

Pathways by source for NDUFA4L2 Gene

Interacting Proteins for NDUFA4L2 Gene

Gene Ontology (GO) - Biological Process for NDUFA4L2 Gene

None

No data available for SIGNOR curated interactions for NDUFA4L2 Gene

Drugs & Compounds for NDUFA4L2 Gene

(5) Drugs for NDUFA4L2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFA4L2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFA4L2: view

Transcripts for NDUFA4L2 Gene

Unigene Clusters for NDUFA4L2 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA4L2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for NDUFA4L2 Gene

GeneLoc Exon Structure for
NDUFA4L2
ECgene alternative splicing isoforms for
NDUFA4L2

Expression for NDUFA4L2 Gene

mRNA expression in normal human tissues for NDUFA4L2 Gene

mRNA differential expression in normal tissues according to GTEx for NDUFA4L2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.5).

Protein differential expression in normal tissues from HIPED for NDUFA4L2 Gene

This gene is overexpressed in Monocytes (35.8), Tlymphocyte (13.7), and Retina (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFA4L2 Gene



SOURCE GeneReport for Unigene cluster for NDUFA4L2 Gene Hs.75069

genes like me logo Genes that share expression patterns with NDUFA4L2: view

Protein tissue co-expression partners for NDUFA4L2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NDUFA4L2 Gene

Orthologs for NDUFA4L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFA4L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFA4L2 35
  • 91.95 (n)
  • 95.4 (a)
NDUFA4L2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFA4L2 36
  • 92 (a)
OneToOne
NDUFA4L2 35
  • 90.8 (n)
  • 91.95 (a)
mouse
(Mus musculus)
Mammalia Ndufa4l2 16
Ndufa4l2 36
  • 94 (a)
OneToOne
Ndufa4l2 35
  • 88.89 (n)
  • 94.25 (a)
rat
(Rattus norvegicus)
Mammalia Ndufa4l2 35
  • 90.04 (n)
  • 94.25 (a)
lizard
(Anolis carolinensis)
Reptilia NDUFA4L2 36
  • 92 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ndufa4l2a 35
  • 67.57 (n)
  • 63.51 (a)
ndufa4l2 36
  • 59 (a)
OneToMany
NDUFA4L2 (1 of 2) 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32230 36
  • 37 (a)
OneToMany
Species with no ortholog for NDUFA4L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFA4L2 Gene

ENSEMBL:
Gene Tree for NDUFA4L2 (if available)
TreeFam:
Gene Tree for NDUFA4L2 (if available)

Paralogs for NDUFA4L2 Gene

Paralogs for NDUFA4L2 Gene

(3) SIMAP similar genes for NDUFA4L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NDUFA4L2: view

Variants for NDUFA4L2 Gene

Sequence variations from dbSNP and Humsavar for NDUFA4L2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7299890 -- 57,241,474(+) GTGTG(C/T)GCGCG upstream-variant-2KB
rs7488015 -- 57,236,354(+) CAACC(A/C)GGCCG intron-variant
rs12299952 -- 57,240,285(+) GACCC(C/G/T)GGCGT intron-variant
rs11829843 -- 57,239,427(+) GGACC(C/G)GAGGG intron-variant
rs34020542 -- 57,237,465(+) TGTGG(-/G)AATGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NDUFA4L2 Gene

Variant ID Type Subtype PubMed ID
dgv96n21 CNV Loss 19592680
nsv519293 CNV Loss 19592680

Variation tolerance for NDUFA4L2 Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFA4L2 Gene

HapMap Linkage Disequilibrium report
NDUFA4L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFA4L2 Gene

Disorders for NDUFA4L2 Gene

Relevant External Links for NDUFA4L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFA4L2

No disorders were found for NDUFA4L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFA4L2 Gene

Publications for NDUFA4L2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  3. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25
  4. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for NDUFA4L2 Gene

Sources for NDUFA4L2 Gene

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