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Aliases for NDUFA4L2 Gene

Aliases for NDUFA4L2 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4-Like 2 2 3
  • NADH-Ubiquinone Oxidoreductase MLRQ Subunit Homolog 3 4
  • NUOMS 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 4-Like 2 3
  • NADH:Ubiquinone Oxidoreductase MLRQ Subunit Homolog 3

External Ids for NDUFA4L2 Gene

Previous GeneCards Identifiers for NDUFA4L2 Gene

  • GC12M055915
  • GC12M057629
  • GC12M054667

Summaries for NDUFA4L2 Gene

GeneCards Summary for NDUFA4L2 Gene

NDUFA4L2 (NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4-Like 2) is a Protein Coding gene. Among its related pathways are Metabolism and Alzheimers disease. An important paralog of this gene is NDUFA4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA4L2 Gene

Genomics for NDUFA4L2 Gene

Regulatory Elements for NDUFA4L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDUFA4L2 Gene

Start:
57,234,903 bp from pter
End:
57,240,762 bp from pter
Size:
5,860 bases
Orientation:
Minus strand

Genomic View for NDUFA4L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFA4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA4L2 Gene

Proteins for NDUFA4L2 Gene

  • Protein details for NDUFA4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX3-NUA4L_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2
    Protein Accession:
    Q9NRX3
    Secondary Accessions:
    • Q6IAH9

    Protein attributes for NDUFA4L2 Gene

    Size:
    87 amino acids
    Molecular mass:
    9966 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NDUFA4L2 Gene

Proteomics data for NDUFA4L2 Gene at MOPED

Post-translational modifications for NDUFA4L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFA4L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFA4L2 Gene

Domains for NDUFA4L2 Gene

Protein Domains for NDUFA4L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFA4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX3

UniProtKB/Swiss-Prot:

NUA4L_HUMAN :
  • Q9NRX3
Family:
  • Belongs to the complex I NDUFA4 subunit family.
genes like me logo Genes that share domains with NDUFA4L2: view

No data available for Gene Families for NDUFA4L2 Gene

Function for NDUFA4L2 Gene

genes like me logo Genes that share phenotypes with NDUFA4L2: view

Animal Model Products

CRISPR Products

miRNA for NDUFA4L2 Gene

miRTarBase miRNAs that target NDUFA4L2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFA4L2 Gene

Localization for NDUFA4L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFA4L2 Gene COMPARTMENTS Subcellular localization image for NDUFA4L2 gene
Compartment Confidence
extracellular 3
mitochondrion 3
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NDUFA4L2 Gene

Pathways for NDUFA4L2 Gene

genes like me logo Genes that share pathways with NDUFA4L2: view

Pathways by source for NDUFA4L2 Gene

Interacting Proteins for NDUFA4L2 Gene

Gene Ontology (GO) - Biological Process for NDUFA4L2 Gene

None

Compounds for NDUFA4L2 Gene

(8) HMDB Compounds for NDUFA4L2 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFA4L2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFA4L2: view

Transcripts for NDUFA4L2 Gene

Unigene Clusters for NDUFA4L2 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFA4L2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA4L2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - -
SP2: - -
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for NDUFA4L2 Gene

GeneLoc Exon Structure for
NDUFA4L2
ECgene alternative splicing isoforms for
NDUFA4L2

Expression for NDUFA4L2 Gene

mRNA expression in normal human tissues for NDUFA4L2 Gene

mRNA differential expression in normal tissues according to GTEx for NDUFA4L2 Gene

This gene is overexpressed in Esophagus - Mucosa (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NDUFA4L2 Gene

SOURCE GeneReport for Unigene cluster for NDUFA4L2 Gene Hs.75069

genes like me logo Genes that share expressions with NDUFA4L2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NDUFA4L2 Gene

Orthologs for NDUFA4L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFA4L2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFA4L2 35
  • 91.95 (n)
  • 95.4 (a)
NDUFA4L2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDUFA4L2 35
  • 90.8 (n)
  • 91.95 (a)
NDUFA4L2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufa4l2 35
  • 88.89 (n)
  • 94.25 (a)
Ndufa4l2 16
Ndufa4l2 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufa4l2 35
  • 90.04 (n)
  • 94.25 (a)
lizard
(Anolis carolinensis)
Reptilia NDUFA4L2 36
  • 92 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ndufa4l2 36
  • 59 (a)
OneToMany
NDUFA4L2 (1 of 2) 36
  • 54 (a)
OneToMany
ndufa4l2a 35
  • 67.57 (n)
  • 63.51 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32230 36
  • 37 (a)
OneToMany
Species with no ortholog for NDUFA4L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFA4L2 Gene

ENSEMBL:
Gene Tree for NDUFA4L2 (if available)
TreeFam:
Gene Tree for NDUFA4L2 (if available)

Paralogs for NDUFA4L2 Gene

Paralogs for NDUFA4L2 Gene

Selected SIMAP similar genes for NDUFA4L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NDUFA4L2: view

Variants for NDUFA4L2 Gene

Sequence variations from dbSNP and Humsavar for NDUFA4L2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3923885 -- 57,240,915(-) TGTCT(A/C)CCTGA upstream-variant-2KB
rs7299890 -- 57,241,474(+) GTGTG(C/T)GCGCG upstream-variant-2KB
rs7488015 -- 57,236,354(+) CAACC(A/C)GGCCG intron-variant
rs9737591 -- 57,238,416(+) GGGGG(C/G)GGGGG intron-variant
rs11172126 -- 57,236,763(+) GCCCA(A/C)CCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFA4L2 Gene

Variant ID Type Subtype PubMed ID
dgv96n21 CNV Loss 19592680
nsv519293 CNV Loss 19592680

Relevant External Links for NDUFA4L2 Gene

HapMap Linkage Disequilibrium report
NDUFA4L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFA4L2 Gene

Disorders for NDUFA4L2 Gene

No disorders were found for NDUFA4L2 Gene.

No data available for UniProtKB/Swiss-Prot for NDUFA4L2 Gene

Publications for NDUFA4L2 Gene

  1. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for NDUFA4L2 Gene

Sources for NDUFA4L2 Gene

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