Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDUFA4L2 Gene

protein-coding   GIFtS: 53
GCID: GC12M057629

NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4-Like...
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at
MalaCards
 

Aliases
for NDUFA4L2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4-Like 21 2
NUOMS2 3
NADH-Ubiquinone Oxidoreductase MLRQ Subunit Homolog2 3
NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 4-Like 22
NADH:Ubiquinone Oxidoreductase MLRQ Subunit Homolog2

External Ids:    HGNC: 298361   Entrez Gene: 569012   Ensembl: ENSG000001856337   UniProtKB: Q9NRX33   
ORGUL members:         
NONCODE14:n341933      

Export aliases for NDUFA4L2 gene to outside databases

Previous GC identifers: GC12M055915 GC12M054667


Summaries
for NDUFA4L2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for NDUFA4L2 Gene: 
NDUFA4L2 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NDUFA4L2 include huntington's disease, and parkinson's disease, and among its related super-pathways are Electron Transport Chain and Metabolism. An important paralog of this gene is NDUFA4.


Genomic Views
for NDUFA4L2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDUFA4L2 gene promoter:
         Nkx3-1   Spz1   HOXA3   Nkx3-1 v1   CUTL1   GATA-1   Nkx3-1 v2   AREB6   HOXA5   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NDUFA4L2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDUFA4L2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFA4L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

NDUFA4L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFA4L2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057629:  view genomic region     (about GC identifiers)

Start:
 57,628,686 bp from pter      End:
 57,634,545 bp from pter
Size:
 5,860 bases      Orientation:
 minus strand

Proteins
for NDUFA4L2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: NUA4L_HUMAN, Q9NRX3 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2  
Size: 87 amino acids; 9966 Da
Secondary accessions: Q6IAH9

Explore the universe of human proteins at neXtProt for NDUFA4L2: NX_Q9NRX3

Explore proteomics data for NDUFA4L2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRX3

    • NDUFA4L2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDUFA4L2 Protein Expression
    REFSEQ proteins: NP_064527.1  
    ENSEMBL proteins: 
     ENSP00000450664   ENSP00000452193   ENSP00000377411  

    Human Recombinant Protein Products for NDUFA4L2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NDUFA4L2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NDUFA4L2
    GenScript Custom Purified and Recombinant Proteins Services for NDUFA4L2
    Novus Biologicals NDUFA4L2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 


    NDUFA4L2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NDUFA4L2
    GenScript Custom Superior Antibodies Services for NDUFA4L2
    Novus Biologicals NDUFA4L2 Antibody
    Abcam antibodies for NDUFA4L2
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for NDUFA4L2
    LSBio Antibodies in human, mouse, rat for NDUFA4L2 

    Assay Products for NDUFA4L2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NDUFA4L2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NDUFA4L2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.

    Protein Domains /
    Families
    for NDUFA4L2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 1 InterPro protein domain:
     IPR010530 B12D

    Graphical View of Domain Structure for InterPro Entry Q9NRX3

    ProtoNet protein and cluster: Q9NRX3

    UniProtKB/Swiss-Prot: NUA4L_HUMAN, Q9NRX3
    Similarity: Belongs to the complex I NDUFA4 subunit family


    NDUFA4L2 for domains           About GeneDecksing


    Function
    for NDUFA4L2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Phenotypes:
         4 GenomeRNAi human phenotypes for NDUFA4L2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NDUFA4L2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDUFA4L2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDUFA4L2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDUFA4L2 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDUFA4L2
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NDUFA4L2 (see all 14):
    hsa-miR-640 hsa-miR-3184 hsa-miR-1321 hsa-miR-1271 hsa-miR-574-3p hsa-miR-765 hsa-miR-3190 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NDUFA4L2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NDUFA4L2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFA4L2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NDUFA4L2
    Sirion Biotech Customized adenovirus for overexpression of NDUFA4L2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NDUFA4L2 (see all 7)
    OriGene ORF clones in mouse, rat for NDUFA4L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDUFA4L2 (NM_020142)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFA4L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFA4L2
    Sirion Biotech Customized lentivirus for stable overexpression of NDUFA4L2 
                         Customized lentivirus expression plasmids for stable overexpression of NDUFA4L2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NDUFA4L2
    Search LifeMap BioReagents cell lines for NDUFA4L2
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFA4L2


    Pathways & Interactions
    for NDUFA4L2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDUFA4L2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    		Oxidative phosphorylation0.64
    		Huntington's disease0.47
    		Parkinson's disease0.61
    		Alzheimer's disease0.46
    		Oxidative phosphorylation0.51
    		Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    		Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NDUFA4L2
        Oxidative phosphorylation


    5/6         Kegg Pathways  (Kegg details for NDUFA4L2) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFA4L2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFA4L2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/22 Interacting proteins for NDUFA4L2 (Q9NRX32, 3 ENSP000003774114) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA9O760272, 3, ENSP000003579434MINT-65616 I2D: score=5 STRING: ENSP00000357943
    C7orf55-LUC7L2Q9Y3832, 3MINT-65626 I2D: score=5 
    KCNA4P224592, 3, ENSP000003285114MINT-65617 I2D: score=5 STRING: ENSP00000328511
    LUC7L2Q9Y3832, 3MINT-65626 I2D: score=5 
    EIF3CQ996132, 3, ENSP000003326044MINT-65623 I2D: score=4 STRING: ENSP00000332604
    About this table

    Drugs & Compounds
    for NDUFA4L2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDUFA4L2 (NUA4L)

    8 HMDB Compounds for NDUFA4L2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFA4L2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about NDUFA4L2 / NUA4L

    Transcripts
    for NDUFA4L2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NDUFA4L2 gene: 
    NM_020142.3  

    Unigene Cluster for NDUFA4L2:

    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
    Hs.75069  [show with all ESTs]
    Unigene Representative Sequence: AK094275
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554503 ENST00000555173(uc010srk.2) ENST00000556732 ENST00000554688
    ENST00000556234 ENST00000557276 ENST00000393825(uc001sno.3)

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NDUFA4L2
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate NDUFA4L2 (see all 14):
    hsa-miR-640 hsa-miR-3184 hsa-miR-1321 hsa-miR-1271 hsa-miR-574-3p hsa-miR-765 hsa-miR-3190 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NDUFA4L2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NDUFA4L2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFA4L2
    Clone
    Products:             		 OriGene clones in human, mouse for NDUFA4L2 (see all 7)
    OriGene ORF clones in mouse, rat for NDUFA4L2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDUFA4L2 (NM_020142)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFA4L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFA4L2
    Sirion Biotech Customized lentivirus for stable overexpression of NDUFA4L2 
                         Customized lentivirus expression plasmids for stable overexpression of NDUFA4L2 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for NDUFA4L2
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFA4L2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFA4L2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFA4L2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFA4L2

    Additional mRNA sequence: 

    AF164796.1 AK094275.1 AK129629.1 BC011910.2 CR457176.1 

    19 DOTS entries:

    DT.450338  DT.100859132  DT.99949983  DT.100859133  DT.100848237  DT.100870151  DT.99981974  DT.100886251 
    DT.97847286  DT.91784339  DT.92426842  DT.121193641  DT.91784496  DT.92407768  DT.100740502  DT.100803976 
    DT.100835452  DT.100886259  DT.307323 

    24/232 AceView cDNA sequences (see all 232):

    BM666906 BM700128 BM790758 AI222888 BM662675 BU579890 BM668781 BG677972 
    BQ776817 BM700373 BQ447435 BM695133 AI183607 BM703785 CA447133 AI830812 
    BM695018 BM712239 AI830828 AI300302 BM851515 AI924323 BQ776502 AA315530 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA4L2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
    SP1:                                                  -     -                           
    SP2:                                                  -     -                           
    SP3:                                                        -                           
    SP4:                                                  -     -                           
    SP5:                                                                                    


    ECgene alternative splicing isoforms for NDUFA4L2

    Expression
    for NDUFA4L2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDUFA4L2 expression in normal human tissues (normalized intensities)      NDUFA4L2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGCCACAG
    NDUFA4L2 Expression
    About this image


    NDUFA4L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 6 entries
             PureStem progenitor F15
     
     Heart (Cardiovascular System)    fully expand to see all 5 entries
             Coronary Artery Smooth Muscle Cells (CASMC)   
             heart/ventricle   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Human Brain Vascular Pericyte (HBVP)   
             brain/midbrain   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             TGFbeta3+BMP7-induced chondrocytes
             Normal Human Articular chondrocytes (NHAC)   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Zeugopod Growth Plate
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells

    See NDUFA4L2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDUFA4L2

    SOURCE GeneReport for Unigene cluster: Hs.75069
        SABiosciences Custom PCR Arrays for NDUFA4L2
    Primer
    Products:    		OriGene qPCR primer pairs and template standards for NDUFA4L2
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFA4L2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDUFA4L2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFA4L2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFA4L2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFA4L2

    Orthologs
    for NDUFA4L2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NDUFA4L2 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ndufa4l21 , 5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more1, 5 88.89(n)1
    94.25(a)1    		   10 (74.51 cM)5
    4077901  NM_001098789.11  NP_001092259.11 
     1275149395 
    lizard
    (Anolis carolinensis)    		 Reptilia NDUFA4L26
    		 Uncharacterized protein
    		 92(a)
    		 1 ↔ 1
    		 GL343212.1(1713800-1716389)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1000030661 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex more 68.02(n)
    64.86(a)    		   100003066  XM_001342673.3  XP_001342709.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG322306
    		 --
    		 37(a)
    		 1 → many
    		 3L(23332426-23339038)


    ENSEMBL Gene Tree for NDUFA4L2 (if available)
    TreeFam Gene Tree for NDUFA4L2 (if available)

    Paralogs
    for NDUFA4L2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDUFA4L2 gene
    NDUFA42  
    3 SIMAP similar genes for NDUFA4L2 using alignment to 2 protein entries:     NUA4L_HUMAN (see all proteins):
    NDUFA4    NMES1    C15orf48

    NDUFA4L2 for paralogs           About GeneDecksing



    Genomic Variants
    for NDUFA4L2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/134 SNPs in NDUFA4L2 are shown (see all 134)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1453267201,2
    		--57629222(+) AACCCA/GGCCTG 1 -- ut310--------
    rs1913832361,2
    		--57629255(+) TGGCCA/GGAGTG 1 -- ut310--------
    rs2003596901,2
    		--57629331(+) CACTGA/GCAGCC 1 -- ut310--------
    rs1464345371,2
    		C--57629355(+) AAGTCT/CGGCCG 2 /P syn11Minor allele frequency- C:0.00NA 4546
    rs1112616741,2
    		C--57629362(+) GCCGGA/C/TCCTTC 3 D G V mis11CSA 1
    rs1829086101,2
    		--57629395(+) AAACTA/GCAAGG 2 A V mis10--------
    rs1997804071,2
    		C--57629409(+) TAAGAC/GGAGAG 1 -- int10--------
    rs2015288981,2
    		C--57629497(+) TAAGAA/GGATGG 1 -- int10--------
    rs2007135341,2
    		--57629499(+) AGAGGA/TTGGGG 1 -- int10--------
    rs1995053101,2
    		C--57629523(+) CCATCA/GAGAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NDUFA4L2 (57628686 - 57634545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NDUFA4L2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv96n21CNV Loss19592680
    nsv519293CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFA4L2
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFA4L2

    Disorders / Diseases
    for NDUFA4L2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 3 diseases for NDUFA4L2:    About MalaCards
    huntington's disease    parkinson's disease    alzheimer's disease


    NDUFA4L2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for NDUFA4L2 gene to outside databases

    Publications
    for NDUFA4L2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDUFA4L2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NDUFA4L2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    3. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    4. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    5. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for NDUFA4L2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NDUFA4L2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56901 HGNC: 29836 AceView: LOC56901 Ensembl:ENSG00000185633 euGenes: HUgn56901
    ECgene: NDUFA4L2 Kegg: 56901 H-InvDB: NDUFA4L2

    Other Databases showing NDUFA4L2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NDUFA4L2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDUFA4L2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NDUFA4L2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NDUFA4L2 gene:
    Search GeneIP for patents involving NDUFA4L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NDUFA4L2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NDUFA4L2  
     OriGene qPCR primer pairs and template standards for NDUFA4L2   OriGene Protein Over-expression Lysate for NDUFA4L2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NDUFA4L2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NDUFA4L2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NDUFA4L2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NDUFA4L2   OriGene Custom Protein Services for NDUFA4L2  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDUFA4L2
     QIAGEN SeqTarget long-range PCR primers for resequencing NDUFA4L2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFA4L2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDUFA4L2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDUFA4L2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDUFA4L2
     GenScript Custom Purified and Recombinant Proteins Services for NDUFA4L2 GenScript cDNA clones with any tag delivered in your preferred vector for NDUFA4L2
     GenScript Custom Assay Services for NDUFA4L2 GenScript Custom Superior Antibodies Services for NDUFA4L2
     GenScript Custom overexpressing Cell Line Services for NDUFA4L2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NDUFA4L2 promoter
     Search Chromatin IP Primers for NDUFA4L2
     RT2 qPCR Primer Assay in human, mouse, rat NDUFA4L2
     Search GNC Networks for NDUFA4L2
     SABiosciences Custom PCR Arrays for NDUFA4L2
     Search Tocris compounds for NDUFA4L2 (NUA4L)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NDUFA4L2 antibodies
     NDUFA4L2 lysates
     Antibodies for NDUFA4L2
     See all of Abcam's Antibodies, Kits and Proteins for NDUFA4L2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for NDUFA4L2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFA4L2
     SwitchGear 3'UTR luciferase reporter plasmids for NDUFA4L2
     SwitchGear Promoter luciferase reporter plasmids for NDUFA4L2
     ThermoFisher Antibody for NDUFA4L2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFA4L2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NDUFA4L2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDUFA4L2
    Customized:
     lentivirus for stable overexpression of NDUFA4L2
     lentivirus expression plasmids for stable overexpression of NDUFA4L2
     adenovirus for overexpression of NDUFA4L2
     LSBio Antibodies in human, mouse, rat for NDUFA4L2
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      NDUFA4L2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4