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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDUFA4 Gene

protein-coding   GIFtS: 58
GCID: GC07M010938

NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4, 9kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4 (9kD,...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4, 9kDa1 2     NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 4 (9kD, MLRQ)1
NADH-Ubiquinone Oxidoreductase MLRQ Subunit1 2 3     CI-9k2
Complex I 9kDa Subunit1 2     MLRQ2
Complex I-MLRQ2 3     NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 42
CI-MLRQ2 3     

External Ids:    HGNC: 76871   Entrez Gene: 46972   Ensembl: ENSG000001890437   OMIM: 6038335   UniProtKB: O004833   

Export aliases for NDUFA4 gene to outside databases

Previous GC identifers: GC07M010617 GC07M010717 GC07M010746


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NDUFA4 Gene:
The protein encoded by this gene belongs to the complex I 9kDa subunit family. Mammalian complex I of
mitochondrial respiratory chain is composed of 45 different subunits. This protein has NADH dehydrogenase
activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate
electron acceptor for the enzyme is believed to be ubiquinone. (provided by RefSeq, Jul 2008)

GeneCards Summary for NDUFA4 Gene: 
NDUFA4 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa) is a protein-coding gene. Diseases associated with NDUFA4 include cerebellar disease, and dandy-walker syndrome, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include cytochrome-c oxidase activity and NADH dehydrogenase (ubiquinone) activity. An important paralog of this gene is NDUFA4L2.

UniProtKB/Swiss-Prot: NDUA4_HUMAN, O00483
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDUFA4 gene promoter:
         GR   COUP-TF1   COUP   HNF-4alpha2   CUTL1   LCR-F1   HNF-4alpha1   COUP-TF   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDUFA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.3   Ensembl cytogenetic band:  7p21.3   HGNC cytogenetic band: 7p21.3

NDUFA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFA4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M010938:  view genomic region     (about GC identifiers)

Start:
10,971,578 bp from pter      End:
10,979,883 bp from pter
Size:
8,306 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 11,025,124-11,033,358     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDUA4_HUMAN, O00483 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4  
Size: 81 amino acids; 9370 Da
Subunit: Mammalian complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
Secondary accessions: A4D109 Q6FHN5

Explore the universe of human proteins at neXtProt for NDUFA4: NX_O00483

Explore proteomics data for NDUFA4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00483

  • NDUFA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDUFA4 Protein Expression
    REFSEQ proteins: NP_002480.1  
    ENSEMBL proteins: 
     ENSP00000339720  
    Reactome Protein details: O00483
    Human Recombinant Protein Products for NDUFA4: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA16729965
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0005751mitochondrial respiratory chain complex IV IDA--

    NDUFA4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comI: Mitochondrial respiratory chain complex / Complex I

    1 InterPro protein domain:
     IPR010530 B12D

    Graphical View of Domain Structure for InterPro Entry O00483

    ProtoNet protein and cluster: O00483

    UniProtKB/Swiss-Prot: NDUA4_HUMAN, O00483
    Similarity: Belongs to the complex I NDUFA4 subunit family


    NDUFA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUA4_HUMAN, O00483
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004129contributes to cytochrome-c oxidase activity IMP--
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    NDUFA4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NDUFA4:
     Increased G2M DNA content 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidNDUFA4 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDUFA4 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.47
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Alzheimer's disease0.46
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFA4
        Electron Transport Chain
    Oxidative phosphorylation

    4        Reactome Pathways for NDUFA4
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport


    5/6         Kegg Pathways  (Kegg details for NDUFA4) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFA4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFA4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/119 Interacting proteins for NDUFA4 (O004832, 3 ENSP000003397204) via UniProtKB, MINT, STRING, and/or I2D (see all 119)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3, ENSP000002504164MINT-8202021 I2D: score=1 STRING: ENSP00000250416
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    WRAP73Q9P2S53, ENSP000002707084I2D: score=1 STRING: ENSP00000270708
    AGO2Q9UKV82, ENSP000002205924MINT-6489217 STRING: ENSP00000220592
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDUFA4 (NDUA4)

    8 HMDB Compounds for NDUFA4    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFA4    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about NDUFA4 / NDUA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDUFA4 gene: 
    NM_002489.3  

    Unigene Cluster for NDUFA4:

    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
    Hs.50098  [show with all ESTs]
    Unigene Representative Sequence: BX538277
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000339600(uc003srx.2) ENST00000482299 ENST00000470761 ENST00000486007
    ENST00000463308 ENST00000492822

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    hsa-miR-4291 hsa-miR-875-3p hsa-miR-513c hsa-miR-642b hsa-miR-3148 hsa-miR-1299 hsa-miR-877 hsa-miR-3606
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    Additional mRNA sequence: 

    AF201077.1 AK024837.1 AK130950.1 BC101794.1 BC101796.1 BC105295.1 BX538277.1 CR407618.1 
    CR541716.1 U94586.1 

    24/38 DOTS entries (see all 38):

    DT.75193342  DT.102833469  DT.92020887  DT.95268814  DT.91671299  DT.95268816  DT.121098743  DT.101962617 
    DT.121098764  DT.121098741  DT.91792998  DT.100032236  DT.101985561  DT.91681103  DT.121098751  DT.100045412 
    DT.100828319  DT.100828321  DT.121098734  DT.91662534  DT.91870631  DT.95236116  DT.97864725  DT.100828315 

    24/953 AceView cDNA sequences (see all 953):

    BM782696 CR407618 AL137966 F27327 W70216 BM782400 BQ421468 H63279 
    AA400793 BF970535 AW849518 F27138 CD676114 AI144195 CA313824 AA583459 
    BX098588 BU607789 AW269706 AI000232 AI185661 T32881 AV712090 CB145328 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDUFA4 expression in normal human tissues (normalized intensities)      NDUFA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGAGATCT
    NDUFA4 Expression
    About this image


    NDUFA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             ganglion/cranial/facial VII   
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             Membranous Facial Bones
             sensory organ/ear/inner ear   
     
     Nose (Sensory Organs)    fully expand to see all 4 entries
             sensory organ/nose/nasal cavity   
     
     Tooth
             visceral organ/oral region/upper jaw   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   

    See NDUFA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDUFA4

    SOURCE GeneReport for Unigene cluster: Hs.50098
        SABiosciences Expression via Pathway-Focused PCR Array including NDUFA4: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NDUFA4 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufa41 , 5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more1, 5 86.42(n)1
    88.89(a)1
      6 (5.01 cM)5
    179921  NM_010886.21  NP_035016.11 
     119003735 
    chicken
    (Gallus gallus)
    Aves NDUFA41 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more 76.13(n)
    76.54(a)
      772135  XM_001234600.2  XP_001234601.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238552 Xenopus laevis transcribed sequence with weak similarity more 71.85(n)    CB984165.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndufa41 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more 64.61(n)
    74.07(a)
      406298  NM_213025.1  NP_998190.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG322306
    --
    51(a)
    1 → many
    3L(23332426-23339038)


    ENSEMBL Gene Tree for NDUFA4 (if available)
    TreeFam Gene Tree for NDUFA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDUFA4 gene
    NDUFA4L22  
    2 SIMAP similar genes for NDUFA4 using alignment to 1 protein entry:     NDUA4_HUMAN:
    NDUFA4L2    NMES1

    NDUFA4 for paralogs           About GeneDecksing


    5/26 Pseudogenes.org Pseudogenes for NDUFA4 (see all 26)
    PGOHUM00000238366 PGOHUM00000242291 PGOHUM00000239719 PGOHUM00000247895 PGOHUM00000261851


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/305 SNPs in NDUFA4 are shown (see all 305)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491611331,2
    C--10971171(+) CAGAAC/TAGCTT 1 -- ds50010--------
    rs78116471,2
    C,F--10971180(+) ttgaaC/Ttcagg 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs77986691,2
    C,F--10971336(+) TGTTAC/TCTTTC 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs1414479781,2
    --10971352(+) AGCATG/TGGTAT 1 -- ds50010--------
    rs1912908181,2
    --10971376(+) AAATGA/CCAATT 1 -- ds50010--------
    rs171637811,2
    C,F--10971416(+) TAGCAG/ATAATA 1 -- ds50016Minor allele frequency- A:0.08NA CSA WA EA 376
    rs1837276331,2
    --10971438(+) AAGACA/GTATCC 1 -- ds50010--------
    rs761831151,2
    --10971462(+) ACTTCA/GTATGT 1 -- ds50010--------
    rs1480592131,2
    --10971476(+) CTTACA/GTTGCA 1 -- ds50010--------
    rs69662701,2
    C,F--10971571(+) GTTATT/CACTAA 1 -- ds50012Minor allele frequency- C:0.10WA 120

    HapMap Linkage Disequilibrium report for NDUFA4 (10971578 - 10979883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NDUFA4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv464364CNV Loss19166990
    nsv887600CNV Gain21882294
    esv2752140CNV Gain17911159
    nsv887601CNV Gain21882294


    Human Gene Mutation Database (HGMD): NDUFA4
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NDUFA4
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFA4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603833    OMIM disorders: --

    5 diseases for NDUFA4:    About MalaCards
    cerebellar disease    dandy-walker syndrome    huntington's disease    parkinson's disease
    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for NDUFA4:
    Dandy-Walker syndrome

    NDUFA4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NDUFA4
    Human Genome Epidemiology (HuGE) Navigator: NDUFA4 (2 documents)

    Export disorders for NDUFA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDUFA4 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with NDUFA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of the human cDNA sequence encoding the NADH:ubiquinone oxidoreductase MLRQ subunit. (PubMed id 9352085)1, 2, 3 Kim J.W.... Choe I.S. (1997)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. Novel, gel-free proteomics approach identifies RNF5 an d JAMP as modulators of GPCR stability. (PubMed id 23798571)1 Roy S.J....Parent J.L. (2013)
    8. SGTA recognizes a noncanonical ubiquitin-like domain i n the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degra dation. (PubMed id 23246001)1 Xu Y....Ye Y. (2012)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4697 HGNC: 7687 AceView: NDUFA4 Ensembl:ENSG00000189043 euGenes: HUgn4697
    ECgene: NDUFA4 Kegg: 4697 H-InvDB: NDUFA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDUFA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDUFA4 gene:
    Search GeneIP for patents involving NDUFA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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