Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NDUFA3 Gene

Aliases for NDUFA3 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 3, 9kDa 2 3
  • NADH-Ubiquinone Oxidoreductase B9 Subunit 3 4
  • Complex I B9 Subunit 2 3
  • Complex I-B9 3 4
  • CI-B9 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 3 (9kD, B9) 2
  • NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 3 3
  • B9 3

External Ids for NDUFA3 Gene

Previous GeneCards Identifiers for NDUFA3 Gene

  • GC19P055251
  • GC19P055030
  • GC19P059282
  • GC19P059297
  • GC19P054590
  • GC19P050923

Summaries for NDUFA3 Gene

GeneCards Summary for NDUFA3 Gene

NDUFA3 (NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 3, 9kDa) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFA3 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA3 Gene

Genomics for NDUFA3 Gene

Regulatory Elements for NDUFA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDUFA3 Gene

Start:
54,102,728 bp from pter
End:
54,109,257 bp from pter
Size:
6,530 bases
Orientation:
Plus strand

Genomic View for NDUFA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA3 Gene

Proteins for NDUFA3 Gene

  • Protein details for NDUFA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95167-NDUA3_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
    Protein Accession:
    O95167
    Secondary Accessions:

    Protein attributes for NDUFA3 Gene

    Size:
    84 amino acids
    Molecular mass:
    9279 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

neXtProt entry for NDUFA3 Gene

Proteomics data for NDUFA3 Gene at MOPED

Post-translational modifications for NDUFA3 Gene

  • Ubiquitination at Lys47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NDUFA3 Gene

Domains for NDUFA3 Gene

Gene Families for NDUFA3 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFA3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95167

UniProtKB/Swiss-Prot:

NDUA3_HUMAN :
  • O95167
Family:
  • Belongs to the complex I NDUFA3 subunit family.
genes like me logo Genes that share domains with NDUFA3: view

Function for NDUFA3 Gene

Molecular function for NDUFA3 Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
genes like me logo Genes that share ontologies with NDUFA3: view

Phenotypes for NDUFA3 Gene

GenomeRNAi human phenotypes for NDUFA3:
genes like me logo Genes that share phenotypes with NDUFA3: view

Animal Model Products

CRISPR Products

miRNA for NDUFA3 Gene

miRTarBase miRNAs that target NDUFA3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFA3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFA3 Gene

Localization for NDUFA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFA3 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFA3 Gene COMPARTMENTS Subcellular localization image for NDUFA3 gene
Compartment Confidence
mitochondrion 5
extracellular 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NDUFA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 20833797
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDUFA3: view

Pathways for NDUFA3 Gene

genes like me logo Genes that share pathways with NDUFA3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Mitochondrial Energy Metabolism in human,mouse,rat

Interacting Proteins for NDUFA3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000398290%0d%0a9606.ENSP00000007516%0d%0a
Selected Interacting proteins: ENSP00000398290 for NDUFA3 Gene via STRING

Symbol External ID(s) Details
NDUFAB1

Gene Ontology (GO) - Biological Process for NDUFA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0022904 respiratory electron transport chain TAS --
GO:0044237 cellular metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NDUFA3: view

Compounds for NDUFA3 Gene

(8) HMDB Compounds for NDUFA3 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFA3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFA3: view

Transcripts for NDUFA3 Gene

Unigene Clusters for NDUFA3 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFA3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: -

Relevant External Links for NDUFA3 Gene

GeneLoc Exon Structure for
NDUFA3
ECgene alternative splicing isoforms for
NDUFA3

Expression for NDUFA3 Gene

mRNA expression in normal human tissues for NDUFA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NDUFA3 Gene

SOURCE GeneReport for Unigene cluster for NDUFA3 Gene Hs.198269

genes like me logo Genes that share expressions with NDUFA3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFA3 Gene

Orthologs for NDUFA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFA3 35
  • 99.6 (n)
  • 100 (a)
NDUFA3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 79 (a)
OneToMany
NDUFA3 35
  • 86.9 (n)
  • 83.33 (a)
NDUFA3 36
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
NDUFA3 36
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ndufa3 35
  • 82.14 (n)
  • 80.95 (a)
Ndufa3 16
Ndufa3 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFA3 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC684509 35
  • 82.94 (n)
  • 80.95 (a)
lizard
(Anolis carolinensis)
Reptilia NDUFA3 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufa3 35
  • 63.01 (n)
  • 63.41 (a)
zebrafish
(Danio rerio)
Actinopterygii NDUFA3 36
  • 56 (a)
OneToOne
zgc:100908 35
  • 67.07 (n)
  • 69.51 (a)
Species with no ortholog for NDUFA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFA3 Gene

ENSEMBL:
Gene Tree for NDUFA3 (if available)
TreeFam:
Gene Tree for NDUFA3 (if available)

Paralogs for NDUFA3 Gene

genes like me logo Genes that share paralogs with NDUFA3: view

No data available for Paralogs for NDUFA3 Gene

Variants for NDUFA3 Gene

Sequence variations from dbSNP and Humsavar for NDUFA3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs254255 -- 54,105,871(-) AGAAG(C/G)TGAGC intron-variant
rs254256 -- 54,105,863(-) AGCCT(C/T)GGCAA intron-variant
rs254257 -- 54,105,720(-) GGGGT(A/C/G/T)GGAGC intron-variant
rs254266 -- 54,106,385(-) GAGAC(A/C)ATCCT intron-variant
rs584689 -- 54,104,907(-) tacaa(A/G)aacag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFA3 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833877 CNV Loss 17160897
nsv510773 CNV Loss 20534489
nsv470157 CNV Loss 18288195
dgv4001n71 CNV Loss 21882294
nsv515623 CNV Loss 19592680

Relevant External Links for NDUFA3 Gene

HapMap Linkage Disequilibrium report
NDUFA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFA3 Gene

Disorders for NDUFA3 Gene

Relevant External Links for NDUFA3

Genetic Association Database (GAD)
NDUFA3
Human Genome Epidemiology (HuGE) Navigator
NDUFA3
genes like me logo Genes that share disorders with NDUFA3: view

No data available for UniProtKB/Swiss-Prot for NDUFA3 Gene

Publications for NDUFA3 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PMID: 12611891) Murray J. … Capaldi R.A. (J. Biol. Chem. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PMID: 17601350) Harris S.E. … Deary I.J. (BMC Genet. 2007) 3 48

Products for NDUFA3 Gene

Sources for NDUFA3 Gene

Back to Top

Content