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Aliases for NDUFA3 Gene

Aliases for NDUFA3 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit A3 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 3, 9kDa 2 3
  • NADH-Ubiquinone Oxidoreductase B9 Subunit 3 4
  • Complex I B9 Subunit 2 3
  • Complex I-B9 3 4
  • CI-B9 3 4
  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 3 (9kD, B9) 2
  • B9 3

External Ids for NDUFA3 Gene

Previous GeneCards Identifiers for NDUFA3 Gene

  • GC19P055251
  • GC19P055030
  • GC19P059282
  • GC19P059297
  • GC19P054590
  • GC19P050923

Summaries for NDUFA3 Gene

GeneCards Summary for NDUFA3 Gene

NDUFA3 (NADH:Ubiquinone Oxidoreductase Subunit A3) is a Protein Coding gene. Among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot for NDUFA3 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA3 Gene

Genomics for NDUFA3 Gene

Regulatory Elements for NDUFA3 Gene

Promoters for NDUFA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDUFA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDUFA3 Gene

Chromosome:
19
Start:
54,102,728 bp from pter
End:
54,109,257 bp from pter
Size:
6,530 bases
Orientation:
Plus strand

Genomic View for NDUFA3 Gene

Genes around NDUFA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA3 Gene

Proteins for NDUFA3 Gene

  • Protein details for NDUFA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95167-NDUA3_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3
    Protein Accession:
    O95167

    Protein attributes for NDUFA3 Gene

    Size:
    84 amino acids
    Molecular mass:
    9279 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.

neXtProt entry for NDUFA3 Gene

Proteomics data for NDUFA3 Gene at MOPED

Post-translational modifications for NDUFA3 Gene

  • Ubiquitination at Lys 47
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NDUFA3 Gene

Domains & Families for NDUFA3 Gene

Protein Domains for NDUFA3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O95167

UniProtKB/Swiss-Prot:

NDUA3_HUMAN :
  • Belongs to the complex I NDUFA3 subunit family.
Family:
  • Belongs to the complex I NDUFA3 subunit family.
genes like me logo Genes that share domains with NDUFA3: view

Function for NDUFA3 Gene

Molecular function for NDUFA3 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
genes like me logo Genes that share phenotypes with NDUFA3: view

Animal Model Products

miRNA for NDUFA3 Gene

miRTarBase miRNAs that target NDUFA3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFA3 Gene

Localization for NDUFA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFA3 Gene

Mitochondrion inner membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFA3 Gene COMPARTMENTS Subcellular localization image for NDUFA3 gene
Compartment Confidence
extracellular 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for NDUFA3 Gene

Pathways & Interactions for NDUFA3 Gene

genes like me logo Genes that share pathways with NDUFA3: view

Interacting Proteins for NDUFA3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000398290%0d%0a9606.ENSP00000007516%0d%0a
Selected Interacting proteins: ENSP00000398290 for NDUFA3 Gene via STRING

Symbol External ID(s) Details
NDUFAB1

Gene Ontology (GO) - Biological Process for NDUFA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS,TAS --
genes like me logo Genes that share ontologies with NDUFA3: view

No data available for SIGNOR curated interactions for NDUFA3 Gene

Drugs & Compounds for NDUFA3 Gene

(5) Drugs for NDUFA3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFA3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
QH2
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
56275-39-9
Sulfide
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
18496-25-8
genes like me logo Genes that share compounds with NDUFA3: view

Transcripts for NDUFA3 Gene

Unigene Clusters for NDUFA3 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4
SP1:
SP2: -

Relevant External Links for NDUFA3 Gene

GeneLoc Exon Structure for
NDUFA3
ECgene alternative splicing isoforms for
NDUFA3

Expression for NDUFA3 Gene

mRNA expression in normal human tissues for NDUFA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NDUFA3 Gene

This gene is overexpressed in Bone (9.0), Retina (8.1), Frontal cortex (6.9), Heart (6.5), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NDUFA3 Gene



SOURCE GeneReport for Unigene cluster for NDUFA3 Gene Hs.198269

genes like me logo Genes that share expression patterns with NDUFA3: view

Protein tissue co-expression partners for NDUFA3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFA3 Gene

Orthologs for NDUFA3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NDUFA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDUFA3 35
  • 86.9 (n)
  • 83.33 (a)
-- 36
  • 79 (a)
OneToMany
NDUFA3 36
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ndufa3 35
  • 82.14 (n)
  • 80.95 (a)
Ndufa3 16
Ndufa3 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDUFA3 35
  • 99.6 (n)
  • 100 (a)
NDUFA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC684509 35
  • 82.94 (n)
  • 80.95 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 55 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
NDUFA3 36
  • 77 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NDUFA3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFA3 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufa3 35
  • 63.01 (n)
  • 63.41 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:100908 35
  • 67.07 (n)
  • 69.51 (a)
NDUFA3 36
  • 56 (a)
OneToOne
Species with no ortholog for NDUFA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFA3 Gene

ENSEMBL:
Gene Tree for NDUFA3 (if available)
TreeFam:
Gene Tree for NDUFA3 (if available)

Paralogs for NDUFA3 Gene

genes like me logo Genes that share paralogs with NDUFA3: view

No data available for Paralogs for NDUFA3 Gene

Variants for NDUFA3 Gene

Sequence variations from dbSNP and Humsavar for NDUFA3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_036175 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for NDUFA3 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833877 CNV Loss 17160897
nsv510773 CNV Loss 20534489
nsv470157 CNV Loss 18288195
dgv4001n71 CNV Loss 21882294
nsv515623 CNV Loss 19592680

Variation tolerance for NDUFA3 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFA3 Gene

HapMap Linkage Disequilibrium report
NDUFA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFA3 Gene

Disorders for NDUFA3 Gene

Relevant External Links for NDUFA3

Genetic Association Database (GAD)
NDUFA3
Human Genome Epidemiology (HuGE) Navigator
NDUFA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDUFA3

No disorders were found for NDUFA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDUFA3 Gene

Publications for NDUFA3 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3
  4. Supernumerary subunits NDUFA3, NDUFA5 and NDUFA12 are required for the formation of the extramembrane arm of human mitochondrial complex I. (PMID: 24717771) Rak M. … Rustin P. (FEBS Lett. 2014) 3
  5. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. (PMID: 20833797) Zhao X. … Jensen O.N. (Mol. Cell Proteomics 2011) 3

Products for NDUFA3 Gene

Sources for NDUFA3 Gene

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