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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDUFA2 Gene

protein-coding   GIFtS: 59
GCID: GC05M140005

NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 2, 8kDa

(Previous names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 (8kD,...)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 2, 8kDa1 2     NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 22
Complex I B8 Subunit1 2     NADH-Ubiquinone Oxidoreductase Subunit CI-B82
NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 2 (8kD, B8)1     CI-B83
B82     Complex I-B83
CD142     NADH-Ubiquinone Oxidoreductase B8 Subunit3
CIB82     

External Ids:    HGNC: 76851   Entrez Gene: 46952   Ensembl: ENSG000001314957   OMIM: 6021375   UniProtKB: O436783   

Export aliases for NDUFA2 gene to outside databases

Previous GC identifers: GC05M139841 GC05M140607 GC05M140008 GC05M140053 GC05M135170


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NDUFA2 Gene:
The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase
(complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial
membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes.
Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder.
Alternative splicing results in multiple transcript variants.(provided by RefSeq, May 2010)

GeneCards Summary for NDUFA2 Gene: 
NDUFA2 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa) is a protein-coding gene. Diseases associated with NDUFA2 include mitochondrial dna deletion syndromes, and multiple cranial nerve palsy, and among its related super-pathways are Electron Transport Chain and Metabolic pathways. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity.

UniProtKB/Swiss-Prot: NDUA2_HUMAN, O43678
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDUFA2 gene promoter:
         CREB   ATF-2   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFA2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDUFA2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDUFA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31.2

NDUFA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFA2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M140005:  view genomic region     (about GC identifiers)

Start:
140,018,325 bp from pter      End:
140,027,370 bp from pter
Size:
9,046 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDUA2_HUMAN, O43678 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2  
Size: 99 amino acids; 10922 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side
1 PDB 3D structure from and Proteopedia for NDUFA2:
1S3A (3D)    
Secondary accessions: D6RJD6 Q6IAY8
Alternative splicing: 2 isoforms:  O43678-1   O43678-2   

Explore the universe of human proteins at neXtProt for NDUFA2: NX_O43678

Explore proteomics data for NDUFA2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O43678

  • NDUFA2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDUFA2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001171941.1  NP_002479.1  

    ENSEMBL proteins: 
     ENSP00000252102   ENSP00000427220  
    Reactome Protein details: O43678
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0031966mitochondrial membrane IDA17209039

    NDUFA2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    comI: Mitochondrial respiratory chain complex / Complex I

    3 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR016464 NADH_Ub_cplx-1_asu_su-2
     IPR007741 Ribosome/NADH_DH

    Graphical View of Domain Structure for InterPro Entry O43678

    ProtoNet protein and cluster: O43678

    1 Blocks protein domain: IPB007741 Mitochondrial ribosome


    NDUFA2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUA2_HUMAN, O43678
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Genatlas biochemistry entry for NDUFA2:
    NADH ubiquinone oxidoreductase (Q reductase),8kDa,component alpha 2,hydrophobic fraction of the complex I
    multi-subunit enzyme of the oxidative phosphorylation (OXPHOS)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
         
    NDUFA2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDUFA2 About                                                                                                See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.61
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.47
    The citric acid (TCA) cycle and respiratory electron transport0.72
    Alzheimer's disease0.46
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Metformin Pathway, Pharmacodynamic
    Metformin Pathway, Pharmacodynamic

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFA2
        Electron Transport Chain
    Oxidative phosphorylation

    4        Reactome Pathways for NDUFA2
        Respiratory electron transport
    Metabolism
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    The citric acid (TCA) cycle and respiratory electron transport

    1 PharmGKB Pathway for NDUFA2
        Metformin Pathway, Pharmacodynamic

    5/6         Kegg Pathways  (Kegg details for NDUFA2) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFA2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFA2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for NDUFA2 (O436782, 3 ENSP000002521024) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMP19Q9Y3282, 3, ENSP000003077224MINT-8263588 I2D: score=2 STRING: ENSP00000307722
    NDUFA7O951823, ENSP000003014574I2D: score=1 STRING: ENSP00000301457
    ENSG00000167774O951823I2D: score=1 
    MT-ND1P038863, ENSP000003546874I2D: score=1 STRING: ENSP00000354687
    MT-ND4P039053, ENSP000003549614I2D: score=1 STRING: ENSP00000354961
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFA2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NDUFA2 (NDUA2)

    8 HMDB Compounds for NDUFA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFA2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about NDUFA2 / NDUA2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDUFA2 gene (2 alternative transcripts): 
    NM_001185012.1  NM_002488.4  

    Unigene Cluster for NDUFA2:

    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
    Hs.75914  [show with all ESTs]
    Unigene Representative Sequence: BF686835
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000510680 ENST00000252102(uc021yem.1 uc003lgp.3) ENST00000512088
    ENST00000502960

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    Additional mRNA sequence: 

    AF047185.1 AF077029.1 BC003674.1 CR457016.1 NR_033697.1 

    15 DOTS entries:

    DT.454420  DT.100839133  DT.95170442  DT.120833481  DT.92459893  DT.120833483  DT.95170441  DT.75193702 
    DT.100839139  DT.95170437  DT.100758886  DT.101955157  DT.120833427  DT.91979006  DT.100839136 

    1 AceView cDNA sequence:

    W96226 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDUFA2 expression in normal human tissues (normalized intensities)      NDUFA2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NDUFA2 Expression
    About this image


    NDUFA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Thalamus
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium   
     
     Bone (Gastrulation Derivatives)
             skeleton/cranium   
     
     Gonad
             Primary Oocyte Primary Follicle

    See NDUFA2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDUFA2

    SOURCE GeneReport for Unigene cluster: Hs.75914
        SABiosciences Expression via Pathway-Focused PCR Array including NDUFA2: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NDUFA2 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufa21 , 5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more1, 5 83.5(n)1
    85.86(a)1
      18 (19.46 cM)5
    179911  NM_010885.41  NP_035015.21 
     367423325 
    chicken
    (Gallus gallus)
    Aves NDUFA21 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more 71.87(n)
    66.67(a)
      768860  XM_001232015.2  XP_001232016.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFA26
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex...
    72(a)
    1 ↔ 1
    4(77812733-77816096)
    zebrafish
    (Danio rerio)
    Actinopterygii ndufa21 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more 68.71(n)
    67.35(a)
      554125  NM_001024420.1  NP_001019591.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG154341 CG15434 57.38(n)
    50.63(a)
      50178  NM_144084.2  NP_652341.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y63D3A.76
    Protein Y63D3A.7
    49(a)
    1 ↔ 1
    I(14113636-14114091)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G478901 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex more 51.59(n)
    52.38(a)
      834840  NM_124163.4  NP_199600.1 
    rice
    (Oryza sativa)
    Liliopsida Os04g03105001 hypothetical protein 62.08(n)
    47.5(a)
      4335450  NM_001058970.2  NP_001052435.2 


    ENSEMBL Gene Tree for NDUFA2 (if available)
    TreeFam Gene Tree for NDUFA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDUFA2 gene

    NDUFA2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NDUFA2
    PGOHUM00000239570


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/155 SNPs in NDUFA2 are shown (see all 155)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361744
    A breast cancer sample4--see VAR_0361742 D N mis40--------
    rs7023981,2
    C,F,A--140301129(+) GGAGTA/GGGCTG 3 -- ds500112Minor allele frequency- G:0.48EA MN WA NA CSA 2051
    rs3723676091,2
    F,H--140301129(+) GGAGT-/A/GGGCTG 3 -- ds50019NS EA NA 776
    rs2021995631,2
    --140301267(+) GAAGAC/GGCCCA 3 -- ds50010--------
    rs1810903891,2
    C--140301344(+) ACTCAC/TTCCCC 3 -- ds50010--------
    rs1851388181,2
    --140301422(+) ATGTTC/TTCTGC 3 -- ds50010--------
    rs1895569931,2
    --140301553(+) GCCCCC/TCCGCC 3 -- ds50010--------
    rs1840643351,2
    --140301599(+) GATGAA/GACAGA 3 -- ut31 nc-transcript-variant0--------
    rs1503444021,2
    --140301665(+) GTAGAA/GGGTAG 3 -- ut31 nc-transcript-variant0--------
    rs603134571,2
    C--140301718(+) CTTTAT/CGAGGA 3 -- ut31 nc-transcript-variant2Minor allele frequency- C:0.03WA 120

    HapMap Linkage Disequilibrium report for NDUFA2 (140018325 - 140027370 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NDUFA2: --

    Human Gene Mutation Database (HGMD): NDUFA2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFA2
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602137   
    OMIM disorders: 256000  
    12 diseases for NDUFA2:    About MalaCards
    mitochondrial dna deletion syndromes    multiple cranial nerve palsy    cranial nerve palsy    leigh syndrome due to mitochondrial complex i deficiency
    leptospirosis    mitochondrial dna-associated leigh syndrome and narp    mitochondrial complex i deficiency    mitochondrial disorders
    huntington's disease    parkinson's disease    anemia    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for NDUFA2:
    Leigh disease

    NDUFA2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NDUFA2
    Human Genome Epidemiology (HuGE) Navigator: NDUFA2 (2 documents)

    Export disorders for NDUFA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDUFA2 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with NDUFA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits. (PubMed id 9425316)1, 2, 3 Ton C....Liew C.C. (1997)
    2. The oxidized subunit B8 from human complex I adopts a thioredoxin fold. (PubMed id 15341729)1, 2, 9 Brockmann C....Oschkinat H. (2004)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    7. Mapping of the NDUFA2, NDUFA6, NDUFA7, NDUFB8, and NDUFS8 electron transport chain genes by intron based radiation hybrid mapping. (PubMed id 9763676)1, 3 Emahazion T. and Brookes A.J. (1998)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4695 HGNC: 7685 AceView: NDUFA2.2 Ensembl:ENSG00000131495 euGenes: HUgn4695
    ECgene: NDUFA2 Kegg: 4695 H-InvDB: NDUFA2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDUFA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDUFA2 gene:
    Search GeneIP for patents involving NDUFA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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