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Aliases for NDUFA13 Gene

Aliases for NDUFA13 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 13 2 3
  • GRIM19 3 4 6
  • Gene Associated With Retinoic And Interferon-Induced Mortality 19 Protein 3 4
  • Gene Associated With Retinoic And IFN-Induced Mortality 19 Protein 3 4
  • NADH-Ubiquinone Oxidoreductase B16.6 Subunit 3 4
  • Cell Death Regulatory Protein GRIM-19 3 4
  • Complex I B16.6 Subunit 2 3
  • Complex I-B16.6 3 4
  • CI-B16.6 3 4
  • GRIM-19 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 13 3
  • Cell Death-Regulatory Protein GRIM19 3
  • CDA016 3
  • CGI-39 3
  • B16.6 3

External Ids for NDUFA13 Gene

Previous GeneCards Identifiers for NDUFA13 Gene

  • GC19P019488
  • GC19P019626
  • GC19P019189

Summaries for NDUFA13 Gene

Entrez Gene Summary for NDUFA13 Gene

  • This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

GeneCards Summary for NDUFA13 Gene

NDUFA13 (NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 13) is a Protein Coding gene. Diseases associated with NDUFA13 include thyroid carcinoma, hurthle cell and thyroid carcinoma, papillary. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity. An important paralog of this gene is ENSG00000258674.

UniProtKB/Swiss-Prot for NDUFA13 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.

Gene Wiki entry for NDUFA13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA13 Gene

Genomics for NDUFA13 Gene

Regulatory Elements for NDUFA13 Gene

Genomic Location for NDUFA13 Gene

Start:
19,515,736 bp from pter
End:
19,529,054 bp from pter
Size:
13,319 bases
Orientation:
Plus strand

Genomic View for NDUFA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFA13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA13 Gene

Proteins for NDUFA13 Gene

  • Protein details for NDUFA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0J0-NDUAD_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
    Protein Accession:
    Q9P0J0
    Secondary Accessions:
    • B4DF76
    • K7EK58
    • Q6PKI0
    • Q9H2L3
    • Q9Y327

    Protein attributes for NDUFA13 Gene

    Size:
    144 amino acids
    Molecular mass:
    16698 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits. Interacts with CARD15, but not with CARD4. Interacts with STAT3, but not with STAT1, STAT2 and STAT5A. Interacts with HHV-8 IRF1, in the nucleus, with HPV-16 E6 and SV40 LT. Interacts with OLFM4.
    SequenceCaution:
    • Sequence=AAD27748.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG44670.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH00589.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NDUFA13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFA13 Gene

Proteomics data for NDUFA13 Gene at MOPED

Post-translational modifications for NDUFA13 Gene

  • Ubiquitination at Lys22, Lys99, and Lys105
  • Modification sites at PhosphoSitePlus

Other Protein References for NDUFA13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDUFA13 Gene

Domains for NDUFA13 Gene

Gene Families for NDUFA13 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFA13 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDUFA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P0J0

UniProtKB/Swiss-Prot:

NDUAD_HUMAN :
  • Q9P0J0
Family:
  • Belongs to the complex I NDUFA13 subunit family.
genes like me logo Genes that share domains with NDUFA13: view

Function for NDUFA13 Gene

Molecular function for NDUFA13 Gene

UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
UniProtKB/Swiss-Prot Induction: By IFNB1/IFN-beta combined with all-trans-retinoic acid (ATRA)

Gene Ontology (GO) - Molecular Function for NDUFA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003954 NADH dehydrogenase activity IMP 16826196
GO:0005515 protein binding IPI 12867595
GO:0005524 ATP binding NAS 10924506
GO:0008137 NADH dehydrogenase (ubiquinone) activity IDA 12611891
genes like me logo Genes that share ontologies with NDUFA13: view
genes like me logo Genes that share phenotypes with NDUFA13: view

Animal Models for NDUFA13 Gene

MGI Knock Outs for NDUFA13:

miRNA for NDUFA13 Gene

miRTarBase miRNAs that target NDUFA13

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NDUFA13 Gene

Localization for NDUFA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFA13 Gene

Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note=May be translocated into the nucleus upon IFN/RA treatment.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFA13 Gene COMPARTMENTS Subcellular localization image for NDUFA13 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NDUFA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA 10924506
GO:0005737 cytoplasm IDA 10924506
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005746 mitochondrial respiratory chain IDA 12611891
genes like me logo Genes that share ontologies with NDUFA13: view

Pathways for NDUFA13 Gene

genes like me logo Genes that share pathways with NDUFA13: view

Gene Ontology (GO) - Biological Process for NDUFA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010952 positive regulation of peptidase activity IC 17297443
GO:0022904 respiratory electron transport chain TAS --
GO:0030308 negative regulation of cell growth IMP 16826196
GO:0035458 cellular response to interferon-beta IDA 17297443
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI 17297443
genes like me logo Genes that share ontologies with NDUFA13: view

Compounds for NDUFA13 Gene

(8) HMDB Compounds for NDUFA13 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFA13 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target

(1) Novoseek inferred chemical compound relationships for NDUFA13 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 46.1 4
genes like me logo Genes that share compounds with NDUFA13: view

Transcripts for NDUFA13 Gene

mRNA/cDNA for NDUFA13 Gene

Unigene Clusters for NDUFA13 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
SP1: - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for NDUFA13 Gene

GeneLoc Exon Structure for
NDUFA13
ECgene alternative splicing isoforms for
NDUFA13

Expression for NDUFA13 Gene

mRNA expression in normal human tissues for NDUFA13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NDUFA13 Gene

SOURCE GeneReport for Unigene cluster for NDUFA13 Gene Hs.534453

mRNA Expression by UniProt/SwissProt for NDUFA13 Gene

Q9P0J0-NDUAD_HUMAN
Tissue specificity: Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis.
genes like me logo Genes that share expressions with NDUFA13: view

No data available for mRNA differential expression in normal tissues for NDUFA13 Gene

Orthologs for NDUFA13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDUFA13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFA13 35
  • 100 (n)
  • 100 (a)
NDUFA13 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFA13 35
  • 83.56 (n)
  • 83.33 (a)
dog
(Canis familiaris)
Mammalia NDUFA13 35
  • 85.19 (n)
  • 88.89 (a)
mouse
(Mus musculus)
Mammalia Ndufa13 35
  • 81.25 (n)
  • 83.33 (a)
Ndufa13 16
Ndufa13 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100911483 35
  • 80.79 (n)
  • 84.72 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75717 35
ndufa13 35
  • 64.12 (n)
  • 70.83 (a)
zebrafish
(Danio rerio)
Actinopterygii ndufa13 35
  • 70.83 (n)
  • 72.22 (a)
zgc73107 35
fruit fly
(Drosophila melanogaster)
Insecta CG3446 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C34B2.8 36
  • 27 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MEE4 35
  • 47.29 (n)
  • 44.44 (a)
rice
(Oryza sativa)
Liliopsida Os03g0192400 35
  • 50.7 (n)
  • 44.54 (a)
Species with no ortholog for NDUFA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFA13 Gene

ENSEMBL:
Gene Tree for NDUFA13 (if available)
TreeFam:
Gene Tree for NDUFA13 (if available)

Paralogs for NDUFA13 Gene

Paralogs for NDUFA13 Gene

Selected SIMAP similar genes for NDUFA13 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NDUFA13: view

Variants for NDUFA13 Gene

Sequence variations from dbSNP and Humsavar for NDUFA13 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3067694 -- 19,522,496(+) TTTTT(-/TT/TTTTTTTTTT)GAGAT intron-variant
rs4808965 -- 19,520,846(+) CAGTG(A/G)AGTCA intron-variant
rs4808966 -- 19,522,780(+) gcagg(G/T)ctttg intron-variant
rs7245689 -- 19,518,721(+) accat(A/G)ccctg intron-variant
rs7250233 -- 19,520,139(+) gcgcc(C/T)ggctG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFA13 Gene

Variant ID Type Subtype PubMed ID
nsv911305 CNV Loss 21882294
nsv509723 CNV Insertion 20534489
dgv3789n71 CNV Loss 21882294

Relevant External Links for NDUFA13 Gene

HapMap Linkage Disequilibrium report
NDUFA13
Human Gene Mutation Database (HGMD)
NDUFA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFA13 Gene

Disorders for NDUFA13 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for NDUFA13 Gene including...

Search for NDUFA13 Gene in MalaCards »

(1) OMIM Diseases for NDUFA13 Gene (609435)

UniProtKB/Swiss-Prot

NDUAD_HUMAN
  • Hurthle cell thyroid carcinoma (HCTC) [MIM:607464]: A rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type. {ECO:0000269 PubMed:15841082}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) Novoseek inferred disease relationships for NDUFA13 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for NDUFA13

Genetic Association Database (GAD)
NDUFA13
Human Genome Epidemiology (HuGE) Navigator
NDUFA13
genes like me logo Genes that share disorders with NDUFA13: view

Publications for NDUFA13 Gene

  1. Identification of GRIM-19, a novel cell death-regulatory gene induced by the interferon-beta and retinoic acid combination, using a genetic approach. (PMID: 10924506) Angell J.E. … Kalvakolanu D.V. (J. Biol. Chem. 2000) 2 3 4 23
  2. Viral interferon regulatory factor 1 of Kaposi's sarcoma-associated herpesvirus interacts with a cell death regulator, GRIM19, and inhibits interferon/retinoic acid-induced cell death. (PMID: 12163600) Seo T. … Choe J. (J. Virol. 2002) 3 4 23
  3. GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I. (PMID: 15367666) Huang G. … Cao X. (Mol. Cell. Biol. 2004) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. (PMID: 15753091) Barnich N. … Podolsky D.K. (J. Biol. Chem. 2005) 3 4

Products for NDUFA13 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NDUFA13
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NDUFA13
    • Block miRNA regulation of NDUFA13 using miScript Target Protectors

    Sources for NDUFA13 Gene

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