Aliases for NDUFA11 Gene
External Ids for NDUFA11 Gene
Previous GeneCards Identifiers for NDUFA11 Gene
This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
GeneCards Summary for NDUFA11 Gene
NDUFA11 (NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 11, 14.7kDa) is a Protein Coding gene. Diseases associated with NDUFA11 include mitochondrial complex i deficiency and leber hereditary optic neuropathy. Among its related pathways are Metabolism and Alzheimers disease. An important paralog of this gene is ENSG00000267740.
UniProtKB/Swiss-Prot for NDUFA11 Gene
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).