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NDUFA11 Gene

protein-coding   GIFtS: 50
GCID: GC19M005891

NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 11,...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 11, 14.7kDa1 2     B14.72
Complex I B14.7 Subunit1 2     NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 112
CI-B14.72 3     Complex I-B14.73
NADH-Ubiquinone Oxidoreductase Subunit B14.72 3     

External Ids:    HGNC: 203711   Entrez Gene: 1263282   Ensembl: ENSG000001748867   OMIM: 6126385   UniProtKB: Q86Y393   

Export aliases for NDUFA11 gene to outside databases

Previous GC identifers: GC19M005962 GC19M005832 GC19M005845 GC19M005651


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDUFA11 Gene:
This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous
subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations
in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in
multiple transcript variants.(provided by RefSeq, Oct 2010)

GeneCards Summary for NDUFA11 Gene:
NDUFA11 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa) is a protein-coding gene. Diseases associated with NDUFA11 include mitochondrial complex i deficiency, and leber hereditary optic neuropathy. An important paralog of this gene is ENSG00000267740.

UniProtKB/Swiss-Prot: NDUAB_HUMAN, Q86Y39
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFA11 gene promoter:
         FAC1   AP-1   ATF-2   MIF-1   c-Jun   Pax-4a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFA11 promoter sequence
   Search Chromatin IP Primers for NDUFA11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFA11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

NDUFA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFA11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005891:  view genomic region     (about GC identifiers)

Start:
5,891,287 bp from pter      End:
5,904,024 bp from pter
Size:
12,738 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NDUAB_HUMAN, Q86Y39 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11  
Size: 141 amino acids; 14852 Da
Subunit: Complex I is composed of 45 different subunits
Sequence caution: Sequence=BAC87088.1; Type=Miscellaneous discrepancy; Note=Erroneous CDS prediction;
Secondary accessions: C9JT23 Q6ZS66
Alternative splicing: 2 isoforms:  Q86Y39-1   Q86Y39-2   (Ref.2 (BAC87088) sequence is in conflict in positions: 160:S->G, 221:T->A)

Explore the universe of human proteins at neXtProt for NDUFA11: NX_Q86Y39

Explore proteomics data for NDUFA11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NDUFA11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001180304.1  NP_783313.1  

    ENSEMBL proteins: 
     ENSP00000389160   ENSP00000467706   ENSP00000466103   ENSP00000311740  
    Reactome Protein details: Q86Y39

    NDUFA11 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    1 InterPro protein domain:
     IPR003397 Tim17/Tim22/Tim23/PMP24

    Graphical View of Domain Structure for InterPro Entry Q86Y39

    ProtoNet protein and cluster: Q86Y39

    UniProtKB/Swiss-Prot: NDUAB_HUMAN, Q86Y39
    Similarity: Belongs to the complex I NDUFA11 subunit family


    NDUFA11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUAB_HUMAN, Q86Y39
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDUFA11
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NDUFA11

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDUAB_HUMAN, Q86Y39: Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    peroxisome2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I IDA12611891
    GO:0016021integral component of membrane IEA--

    NDUFA11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDUFA11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Huntington's disease0.45
    Oxidative phosphorylation0.64
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44
    4Metformin Pathway, Pharmacodynamic
    Metformin Pathway, Pharmacodynamic

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for NDUFA11
        Oxidative phosphorylation

    1 Reactome Pathway for NDUFA11
        Respiratory electron transport

    1 PharmGKB Pathway for NDUFA11
        Metformin Pathway, Pharmacodynamic

    Selected Kegg Pathways  (Kegg details for NDUFA11) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease


    NDUFA11 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFA11: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFA11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFA11 (Q86Y393 ENSP000003117404) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    NDUFC1ENSP000003777704STRING: ENSP00000377770 STRING: ENSP00000265500
    CYC1ENSP000003171594STRING: ENSP00000317159
    MT-CYBENSP000003545544STRING: ENSP00000354554
    MT-ND1ENSP000003546874STRING: ENSP00000354687
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022904respiratory electron transport chain TAS--
    GO:0044237cellular metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    NDUFA11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFA11 (NDUAB)

    8 HMDB Compounds for NDUFA11    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFA11    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NDUFA11 gene (2 alternative transcripts): 
    NM_001193375.1  NM_175614.4  

    Unigene Cluster for NDUFA11:

    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa
    Hs.406062  [show with all ESTs]
    Unigene Representative Sequence: NM_001193375
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000418389(uc002mdp.2) ENST00000592634 ENST00000593233 ENST00000308961(uc002mdr.2 uc002mdq.2)
    ENST00000591341 ENST00000591160

    miRNA
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    hsa-miR-33a* hsa-miR-4260 hsa-miR-4308
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      QuantiFast Probe-based Assays in human, mouse, rat NDUFA11

    Additional mRNA sequence: 

    AJ539081.1 AK127692.1 BC069045.1 NR_034166.2 

    4 DOTS entries:

    DT.456249  DT.100821178  DT.95203416  DT.101984953 

    Selected AceView cDNA sequences (see all 332):

    AI370556 AJ346389 AI766353 AI086428 AJ572721 F19162 BU154397 BQ671956 
    BU782826 AI186053 BQ642735 BQ671667 BM771509 BM856137 AI350889 BQ427600 
    AA721382 AL702102 BC069045 CR604632 AI084153 CD109073 BI833694 CB155266 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDUFA11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCGCGAGAA
    NDUFA11 Expression
    About this image

    NDUFA11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFA11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406062
        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFA11: 
              Mitochondrial Energy Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFA11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDUFA11 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufa111 , 5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex more1, 5 72.81(n)1
    64.54(a)1
      17 (29.47 cM)5
    698751  NM_027244.11  NP_081520.11 
     567177625 
    chicken
    (Gallus gallus)
    Aves NDUFA111 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more 58.65(n)
    48.12(a)
      420060  XM_429731.4  XP_429731.4 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ndufa111 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more 52.78(n)
    52.27(a)
      100170627  NM_001130386.1  NP_001123858.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndufa111 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more 54.64(n)
    49.62(a)
      393497  NM_200525.2  NP_956819.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG93506
    --
    23(a)
    1 → many
    2R(16912585-16913591)


    ENSEMBL Gene Tree for NDUFA11 (if available)
    TreeFam Gene Tree for NDUFA11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDUFA11 gene
    ENSG000002677402  

    NDUFA11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDUFA11 (see all 350)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs81825111,2
    C--5661166(+) tttttC/Ttttct 3 -- int1 trp30--------
    rs1809249721,2
    --5815451(+) TACTGA/CCAGGC 1 -- ds50010--------
    rs129723851,2
    C,F,A,H--5815501(+) taaaaC/Taggac 1 -- ds500123Minor allele frequency- T:0.43NS EA NA WA 2762
    rs766837581,2
    C,F--5815555(+) AGCCAA/GAAATA 1 -- ds50011Minor allele frequency- G:0.03NA 120
    rs104203961,2
    C,F--5815579(+) CACCTG/CCCTGG 1 -- ds50012Minor allele frequency- C:0.10WA 120
    rs762663341,2
    C--5815625(+) CCCCCC/TTTTTT 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs1463949021,2
    --5815685(+) GCGGCA/GGGGCC 1 -- ds50010--------
    rs16788651,2
    C,F,A--5815698(+) GGTCAA/GCGCCA 1 -- ds50018Minor allele frequency- G:0.45NA WA EA 368
    rs1852019411,2
    --5815700(+) TCAGCA/GCCAGC 1 -- ds50010--------
    rs678494011,2
    C--5815713(+) AGGCC-/AGCGTT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NDUFA11 (5891287 - 5904024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NDUFA11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910905CNV Loss21882294
    nsv910906CNV Loss21882294
    nsv910904CNV Loss21882294
    nsv910907CNV Loss21882294
    dgv3693n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): NDUFA11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFA11
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFA11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612638   
    OMIM disorders: 252010  
    UniProtKB/Swiss-Prot: NDUAB_HUMAN, Q86Y39
  • Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory
    chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset
    neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific
    encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and
    some forms of Parkinson disease. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 14 diseases for NDUFA11:    About MalaCards
    mitochondrial complex i deficiency    leber hereditary optic neuropathy    lactic acidosis    leukodystrophy
    huntington's disease    fatty liver disease    neuropathy    myopathy
    parkinson's disease    liver disease    alzheimer's disease    multiple myeloma
    myeloma    leukemia


    NDUFA11 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for NDUFA11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDUFA11 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with NDUFA11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mitochondrial complex I deficiency caused by a deleterious NDUFA11 mutation. (PubMed id 18306244)1, 2 Berger I....Elpeleg O. (Ann. Neurol. 2008)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    5. Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits. (PubMed id 12381726)1, 3 Carroll J....Hirst J. (J. Biol. Chem. 2002)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 126328 HGNC: 20371 AceView: NDUFA11 Ensembl:ENSG00000174886 euGenes: HUgn126328
    ECgene: NDUFA11 Kegg: 126328 H-InvDB: NDUFA11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDUFA11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDUFA11 gene:
    Search GeneIP for patents involving NDUFA11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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