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Aliases for NDUFA11 Gene

Aliases for NDUFA11 Gene

  • NADH:Ubiquinone Oxidoreductase Subunit A11 2 3 5
  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 11, 14.7kDa 2 3
  • NADH-Ubiquinone Oxidoreductase Subunit B14.7 3 4
  • Complex I B14.7 Subunit 2 3
  • CI-B14.7 3 4
  • Complex I-B14.7 4
  • B14.7 3

External Ids for NDUFA11 Gene

Previous GeneCards Identifiers for NDUFA11 Gene

  • GC19M005962
  • GC19M005832
  • GC19M005845
  • GC19M005651

Summaries for NDUFA11 Gene

Entrez Gene Summary for NDUFA11 Gene

  • This gene encodes a subunit of the membrane-bound mitochondrial complex I. Complex I is composed of numerous subunits and functions as the NADH-ubiquinol reductase of the mitochondrial electron transport chain. Mutations in this gene are associated with severe mitochondrial complex I deficiency. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

GeneCards Summary for NDUFA11 Gene

NDUFA11 (NADH:Ubiquinone Oxidoreductase Subunit A11) is a Protein Coding gene. Diseases associated with NDUFA11 include Mitochondrial Complex I Deficiency and Leber Hereditary Optic Neuropathy. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Metabolism. An important paralog of this gene is ENSG00000267740.

UniProtKB/Swiss-Prot for NDUFA11 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA11 Gene

Genomics for NDUFA11 Gene

Regulatory Elements for NDUFA11 Gene

Enhancers for NDUFA11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NDUFA11 on UCSC Golden Path with GeneCards custom track

Promoters for NDUFA11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDUFA11 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDUFA11 Gene

5,891,276 bp from pter
5,904,013 bp from pter
12,738 bases
Minus strand

Genomic View for NDUFA11 Gene

Genes around NDUFA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDUFA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDUFA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA11 Gene

Proteins for NDUFA11 Gene

  • Protein details for NDUFA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11
    Protein Accession:
    Secondary Accessions:
    • C9JT23
    • Q6ZS66

    Protein attributes for NDUFA11 Gene

    141 amino acids
    Molecular mass:
    14852 Da
    Quaternary structure:
    • Complex I is composed of 45 different subunits.
    • Sequence=BAC87088.1; Type=Miscellaneous discrepancy; Note=Erroneous CDS prediction.; Evidence={ECO:0000305};

    Alternative splice isoforms for NDUFA11 Gene


neXtProt entry for NDUFA11 Gene

Proteomics data for NDUFA11 Gene at MOPED

Post-translational modifications for NDUFA11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDUFA11 Gene

No data available for DME Specific Peptides for NDUFA11 Gene

Domains & Families for NDUFA11 Gene

Protein Domains for NDUFA11 Gene


Suggested Antigen Peptide Sequences for NDUFA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the complex I NDUFA11 subunit family.
  • Belongs to the complex I NDUFA11 subunit family.
genes like me logo Genes that share domains with NDUFA11: view

Function for NDUFA11 Gene

Molecular function for NDUFA11 Gene

UniProtKB/Swiss-Prot Function:
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
genes like me logo Genes that share phenotypes with NDUFA11: view

Human Phenotype Ontology for NDUFA11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for NDUFA11 Gene

Localization for NDUFA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFA11 Gene

Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side.

Subcellular locations from

Jensen Localization Image for NDUFA11 Gene COMPARTMENTS Subcellular localization image for NDUFA11 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NDUFA11 Gene

Pathways & Interactions for NDUFA11 Gene

genes like me logo Genes that share pathways with NDUFA11: view

Gene Ontology (GO) - Biological Process for NDUFA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone TAS --
genes like me logo Genes that share ontologies with NDUFA11: view

No data available for SIGNOR curated interactions for NDUFA11 Gene

Drugs & Compounds for NDUFA11 Gene

(5) Drugs for NDUFA11 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Ubiquinone-1 Experimental Pharma 0
Ubiquinone-2 Experimental Pharma 0
NADH Nutra Target 0
NAD Pharma Full agonist, Agonist 0

(3) Additional Compounds for NDUFA11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
  • Coenzymes QH2
  • CoQH2
  • Reduced ubiquinone
  • Ubiquinol
  • Ubiquinone-1
  • Sulfanediide
  • Sulfide
  • Sulfur
  • Sulphide
genes like me logo Genes that share compounds with NDUFA11: view

Transcripts for NDUFA11 Gene

Unigene Clusters for NDUFA11 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA11 Gene

No ASD Table

Relevant External Links for NDUFA11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NDUFA11 Gene

mRNA expression in normal human tissues for NDUFA11 Gene

Protein differential expression in normal tissues from HIPED for NDUFA11 Gene

This gene is overexpressed in Heart (10.8) and Frontal cortex (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFA11 Gene

SOURCE GeneReport for Unigene cluster for NDUFA11 Gene Hs.406062

genes like me logo Genes that share expression patterns with NDUFA11: view

Protein tissue co-expression partners for NDUFA11 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NDUFA11 Gene

Orthologs for NDUFA11 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFA11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NDUFA11 35
  • 79.2 (n)
  • 72.34 (a)
NDUFA11 36
  • 57 (a)
(Canis familiaris)
Mammalia NDUFA11 35
  • 80.85 (n)
  • 71.63 (a)
-- 36
  • 56 (a)
(Mus musculus)
Mammalia Ndufa11 35
  • 72.81 (n)
  • 64.54 (a)
Ndufa11 16
Ndufa11 36
  • 52 (a)
(Pan troglodytes)
Mammalia NDUFA11 35
  • 99.76 (n)
  • 100 (a)
NDUFA11 36
  • 76 (a)
(Rattus norvegicus)
Mammalia Ndufa11 35
  • 73.29 (n)
  • 66.67 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 44 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
(Gallus gallus)
Aves NDUFA11 35
  • 58.65 (n)
  • 48.12 (a)
-- 36
  • 39 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufa11 35
  • 52.78 (n)
  • 52.27 (a)
(Danio rerio)
Actinopterygii ndufa11 35
  • 54.64 (n)
  • 49.62 (a)
ndufa11 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9350 36
  • 23 (a)
Species with no ortholog for NDUFA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NDUFA11 Gene

Gene Tree for NDUFA11 (if available)
Gene Tree for NDUFA11 (if available)

Paralogs for NDUFA11 Gene

Paralogs for NDUFA11 Gene

genes like me logo Genes that share paralogs with NDUFA11: view

Variants for NDUFA11 Gene

Sequence variations from dbSNP and Humsavar for NDUFA11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs778800 -- 5,900,236(-) GTGGG(A/G)GGCTC intron-variant
rs778801 -- 5,899,374(-) CAGGA(A/G)ATGGA intron-variant
rs7257835 -- 5,895,184(+) CACAT(C/T)GGTGT intron-variant
rs12980262 -- 5,893,047(+) CCCGG(A/G)CACCC reference, missense
rs12982527 -- 5,893,214(+) gcact(C/T)tggga reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NDUFA11 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
nsv910904 CNV Loss 21882294
nsv910905 CNV Loss 21882294
nsv910906 CNV Loss 21882294
nsv910907 CNV Loss 21882294

Variation tolerance for NDUFA11 Gene

Gene Damage Index Score: 5.29; 70.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDUFA11 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDUFA11 Gene

Disorders for NDUFA11 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NDUFA11 Gene - From: OMIM, ClinVar, and GeneCards

Disorder Aliases PubMed IDs
mitochondrial complex i deficiency
  • mitochondrial complex 1 deficiency
leber hereditary optic neuropathy
  • leber optic atrophy
leigh syndrome
  • leigh syndrome due to mitochondrial complex i deficiency
- elite association - COSMIC cancer census association via MalaCards


  • Mitochondrial complex I deficiency (MT-C1D) [MIM:252010]: A disorder of the mitochondrial respiratory chain that causes a wide range of clinical manifestations from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. {ECO:0000269 PubMed:18306244}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NDUFA11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NDUFA11: view

No data available for Genatlas for NDUFA11 Gene

Publications for NDUFA11 Gene

  1. Mitochondrial complex I deficiency caused by a deleterious NDUFA11 mutation. (PMID: 18306244) Berger I. … Elpeleg O. (Ann. Neurol. 2008) 3 4 67
  2. Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits. (PMID: 12381726) Carroll J. … Hirst J. (J. Biol. Chem. 2002) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. (PMID: 26465331) Grose J.H. … Benjamin I.J. (PLoS ONE 2015) 3
  5. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3

Products for NDUFA11 Gene

Sources for NDUFA11 Gene