Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NDUFA10 Gene

protein-coding   GIFtS: 64
GCID: GC02M240854

NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 10,...

(Previous names: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 (42kD))
  See NDUFA10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 10, 42kDa1 2     CI-42k2
Complex I 42kDa Subunit1 2     NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 10,
Mitochondrial2
NADH-Ubiquinone Oxidoreductase 42 KDa Subunit2 3     CI-42kD3
NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 10 (42kD)1     Complex I-42kD3
CI-42KD2     

External Ids:    HGNC: 76841   Entrez Gene: 47052   Ensembl: ENSG000001304147   OMIM: 6038355   UniProtKB: O952993   

Export aliases for NDUFA10 gene to outside databases

Previous GC identifers: GC02P240548 GC02P241389 GC02M241220 GC02M240620 GC02M240548 GC02M232656


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NDUFA10 Gene:
The protein encoded by this gene belongs to the complex I 42kDA subunit family. Mammalian complex I is the first
enzyme complex in the electron transport chain of mitochondria. It is composed of 45 different subunits. This
protein is a component of the hydrophobic protein fraction and has NADH dehydrogenase activity and oxidoreductase
activity. It transfers electrons from NADH to the respiratory chain. (provided by RefSeq, Jul 2008)

GeneCards Summary for NDUFA10 Gene:
NDUFA10 (NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa) is a protein-coding gene. Diseases associated with NDUFA10 include leigh syndrome with leukodystrophy, and leigh disease. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and phosphotransferase activity, alcohol group as acceptor.

UniProtKB/Swiss-Prot: NDUAA_HUMAN, O95299
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFA10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDUFA10 gene promoter:
         ER-alpha   AP-2alpha isoform 3   AP-2alpha isoform 2   E4BP4   RORalpha2   GATA-2   HOXA5   AP-2alpha isoform 4   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDUFA10 promoter sequence
   Search Chromatin IP Primers for NDUFA10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

NDUFA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDUFA10 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M240854:  view genomic region     (about GC identifiers)

Start:
240,831,867 bp from pter      End:
240,964,819 bp from pter
Size:
132,953 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NDUAA_HUMAN, O95299 (See protein sequence)
Recommended Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial precursor  
Size: 355 amino acids; 40751 Da
Cofactor: Binds 1 FAD per subunit
Subunit: Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction

Explore the universe of human proteins at neXtProt for NDUFA10: NX_O95299

Explore proteomics data for NDUFA10 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys48, Lys102, Lys243, Lys277, Lys280, Lys285, Lys338, Lys350
  • Modification sites at PhosphoSitePlus

  • See NDUFA10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004535.1  
    ENSEMBL proteins: 
     ENSP00000408055   ENSP00000252711   ENSP00000385697   ENSP00000411527   ENSP00000403080  
     ENSP00000408224   ENSP00000302321   ENSP00000388413   ENSP00000383975  
    Reactome Protein details: O95299

    NDUFA10 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NDUFA10
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NDUFA10
    GenScript Custom Purified and Recombinant Proteins Services for NDUFA10
    Novus Biologicals NDUFA10 Protein
    Novus Biologicals NDUFA10 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NDUFA10 

     
    antibodies-online proteins for NDUFA10 (7 products) 

     
    Search antibodies-online for peptides for NDUFA10

    NDUFA10 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NDUFA10
    OriGene Custom Antibody Services for NDUFA10
    Novus Biologicals NDUFA10 Antibody
    Abcam antibodies for NDUFA10
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for NDUFA10
    antibodies-online antibodies for NDUFA10 (28 products) 

    NDUFA10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NDUFA10
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NDUFA10
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NDUFA10 
    antibodies-online kits for NDUFA10 (5 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    comI: Mitochondrial respiratory chain complex / Complex I

    3 InterPro protein domains:
     IPR015828 NADH_UbQ_OxRdtase_42KD_su
     IPR027417 P-loop_NTPase
     IPR002624 Deoxynucleoside_kinase

    Graphical View of Domain Structure for InterPro Entry O95299

    ProtoNet protein and cluster: O95299

    1 Blocks protein domain: IPB002624 Deoxynucleoside kinase

    UniProtKB/Swiss-Prot: NDUAA_HUMAN, O95299
    Similarity: Belongs to the complex I NDUFA10 subunit family


    Find genes that share domains with NDUFA10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDUAA_HUMAN, O95299
    Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that
    is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the
    respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

         Genatlas biochemistry entry for NDUFA10:
    NADH ubiquinone oxidoreductase 10 (Q reductase),42kDa,component alpha 10,hydrophobic fraction of the complex
    I,multisubunit enzyme of oxidative phosphorylation (OXPHOS),inner mitochondrial membrane

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005524ATP binding IEA--
    GO:0008137NADH dehydrogenase (ubiquinone) activity NAS9878551
    GO:0016773phosphotransferase activity, alcohol group as acceptor IEA--
         
    Find genes that share ontologies with NDUFA10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NDUFA10:
     Increased cell death HMECs cel 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NDUFA10

    miRNA
    Products:
        
    miRTarBase miRNAs that target NDUFA10:
    hsa-mir-615-3p (MIRT039891), hsa-let-7b-5p (MIRT051977)

    Block miRNA regulation of human, mouse, rat NDUFA10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NDUFA10:
    hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidNDUFA10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NDUFA10
    Predesigned siRNA for gene silencing in human, mouse, rat NDUFA10

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NDUFA10

    Clone
    Products:
         
    OriGene clones in human, mouse for NDUFA10 (see all 7)
    OriGene ORF clones in mouse, rat for NDUFA10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDUFA10 (NM_004544)
    Sino Biological Human cDNA Clone for NDUFA10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFA10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFA10

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NDUFA10
    Browse ESI BIO Cell Lines and PureStem Progenitors for NDUFA10 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFA10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NDUAA_HUMAN, O95299: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane TAS--
    GO:0005747mitochondrial respiratory chain complex I NAS9878551
    GO:0005759mitochondrial matrix IEA--

    Find genes that share ontologies with NDUFA10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NDUFA10 About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.0.81
    Parkinson's disease0.57
    Respiratory electron transport0.81
    Oxidative phosphorylation0.51
    Electron Transport Chain0.75
    Huntington's disease0.45
    The citric acid (TCA) cycle and respiratory electron transport0.71
    Non-alcoholic fatty liver disease (NAFLD)0.41
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Alzheimer's disease
    Alzheimer's disease0.44


    Find genes that share SuperPaths with NDUFA10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NDUFA10
        Oxidative phosphorylation
    Electron Transport Chain


    1 Reactome Pathway for NDUFA10
        Respiratory electron transport


    Selected Kegg Pathways  (Kegg details for NDUFA10) (see all 6):
        Oxidative phosphorylation
    Metabolic pathways
    Non-alcoholic fatty liver disease (NAFLD)
    Alzheimer's disease
    Parkinson's disease

        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFA10: 
              Mitochondrial Energy Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NDUFA10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDUFA10 (O952993 ENSP000002527114) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDUFA2O436783, ENSP000002521024I2D: score=1 STRING: ENSP00000252102
    BRCC3P467363, ENSP000003819984I2D: score=2 STRING: ENSP00000381998
    WIPI2Q9Y4P83, ENSP000002888284I2D: score=1 STRING: ENSP00000288828
    ATG5Q9H1Y03I2D: score=5 
    MMEP084733I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006120mitochondrial electron transport, NADH to ubiquinone NAS9878551
    GO:0006139nucleobase-containing compound metabolic process IEA--
    GO:0022904respiratory electron transport chain TAS--
    GO:0042493response to drug IEA--
    GO:0044237cellular metabolic process TAS--

    Find genes that share ontologies with NDUFA10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDUFA10 (NDUAA)

    8 HMDB Compounds for NDUFA10    About this table
    CompoundSynonyms CAS #PubMed Ids
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    IronArmco iron (see all 19)7439-89-6--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    QH2CoQH2 (see all 5)56275-39-9--
    SulfideSulfide (see all 4)18496-25-8--
    Ubiquinone Q1Coenzyme Q (see all 9)727-81-1--
    Ubiquinone Q22-(3,7-dimethyl-2,6-octadienyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione (see all 7)606-06-4--

    1 DrugBank Compound for NDUFA10    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NDUFA10 gene: 
    NM_004544.3  

    Unigene Cluster for NDUFA10:

    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
    Hs.277677  [show with all ESTs]
    Unigene Representative Sequence: NM_004544
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419408 ENST00000252711(uc002vyn.3) ENST00000471378 ENST00000476216
    ENST00000404554 ENST00000485344(uc002vyo.2) ENST00000443626 ENST00000444548
    ENST00000448880 ENST00000307300(uc010fzc.2) ENST00000414580 ENST00000407129(uc002vyp.3)
    ENST00000497536
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NDUFA10 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NDUFA10:
    hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidNDUFA10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NDUFA10
    Predesigned siRNA for gene silencing in human, mouse, rat NDUFA10
    Clone
    Products:
         
    OriGene clones in human, mouse for NDUFA10 (see all 7)
    OriGene ORF clones in mouse, rat for NDUFA10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NDUFA10 (NM_004544)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDUFA10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFA10
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NDUFA10
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFA10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDUFA10
      QuantiTect SYBR Green Assays in human, mouse, rat NDUFA10
      QuantiFast Probe-based Assays in human, mouse, rat NDUFA10

    Additional mRNA sequence: 

    AF087661.1 AF087854.1 AF453834.1 AK025576.1 AK091719.1 AK290778.1 BC003417.1 BC031332.1 

    15 DOTS entries:

    DT.446722  DT.100814486  DT.443883  DT.97848232  DT.102842729  DT.102842727  DT.95140497  DT.95148049 
    DT.100814487  DT.120940463  DT.91767163  DT.100652691  DT.100714227  DT.120940423  DT.40283658 

    Selected AceView cDNA sequences (see all 453):

    BM664637 BU681422 BM910495 BG393904 AA398398 CA417030 BQ267272 BG255505 
    BF433257 BE217983 AA485823 CR593117 BQ272523 AK091719 BQ682823 BM998518 
    BM839752 BQ686882 CA427897 BQ671174 AA365003 AI191141 BU626523 AI422450 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA10 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                              -                       -     -                                       
    SP2:                                                        -     -     -                       -                             -         
    SP3:                                                        -     -     -                       -                                       
    SP4:                                                        -     -     -     -     -     -     -     -                                 
    SP5:                                                        -     -     -                                                               


    ECgene alternative splicing isoforms for NDUFA10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NDUFA10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAATGAG
    NDUFA10 Expression
    About this image


    NDUFA10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Bone (Muscoskeletal System)
             Membranous Facial Bones
     
     Neural Tube (Nervous System)
             Telencephalon
    NDUFA10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDUFA10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.277677
        Pathway & Disease-focused RT2 Profiler PCR Array including NDUFA10: 
              Mitochondrial Energy Metabolism in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NDUFA10
    OriGene qSTAR qPCR primer pairs in human, mouse for NDUFA10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDUFA10
    QuantiTect SYBR Green Assays in human, mouse, rat NDUFA10
    QuantiFast Probe-based Assays in human, mouse, rat NDUFA10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFA10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NDUFA10 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndufa101 , 5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex more1, 5 79.06(n)1
    76.62(a)1
      1 (46.40 cM)5
    672731  NM_024197.11  NP_077159.11 
     924390105 
    chicken
    (Gallus gallus)
    Aves NDUFA101 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, more 65.21(n)
    61.63(a)
      424032  NM_001031247.1  NP_001026418.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDUFA106
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex...
    59(a)
    1 ↔ 1
    GL343858.1(24938-41509)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.259132 Xenopus laevis transcribed sequence with weak similarity more 70.91(n)    BJ066216.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC059660.12   -- 71.3(n)   321951  BC059660.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ND421 , 3 electron transport NADH dehydrogenase
    (ubiquinone)3
    NADH:ubiquinone reductase 42kD subunit precursor1
    35(a)3
    48.35(n)1
    38.02(a)1
      93F133
    425911  NM_001275892.11  NP_001262821.11 
    worm
    (Caenorhabditis elegans)
    Secernentea nuo-41 nuo-4 43.92(n)
    35.45(a)
      176001  NM_171184.4  NP_741215.1 


    ENSEMBL Gene Tree for NDUFA10 (if available)
    TreeFam Gene Tree for NDUFA10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NDUFA10 (see all 1669)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1384794901,2
    C--232658655(+) GCTGT-/GGGGGA 1 -- int10--------
    rs714046251,2
    C--232659674(+) TGTGT-/ACAC  
     
    /ACACAC
    ACACA
    2 -- int1 cds11NA 2
    rs67229151,2
    C,F,A--232660616(+) ACACAC/AAAAAA 1 -- int12Minor allele frequency- A:0.50WA NA 4
    rs67386671,2
    C,F,A,H--232660617(+) CACACA/GAAAAA 1 -- int1 trp36Minor allele frequency- G:0.00NS EA WA NA 402
    rs1449058511,2
    --232660617(+) ACACA-/AGAAAAA 1 -- int10--------
    rs570451271,2
    C--232664332(+) TTTTTT/CCCTAA 1 -- int14Minor allele frequency- C:0.17WA NA CSA 6
    rs591286531,2
    C--232664332(+) TTTTT-/C/T   
       
    /TTTC
    CCTAA
    1 -- int11NA 2
    rs340366981,2
    C--232667349(+) GACAG-/AGTCACA 1 -- int10--------
    rs41495661,2
    C--232678841(-) TCTCTTT/-CTGTA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs347380631,2
    C--232684361(+) CCACA-/TTTGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NDUFA10 (240831867 - 240964819 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NDUFA10 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721887CNV Deletion23290073
    esv2423154CNV Deletion19546169
    esv2721886CNV Deletion23290073
    esv2166282CNV Deletion18987734
    nsv3235CNV Insertion18451855
    nsv214120CNV Loss16902084
    nsv876100CNV Loss21882294
    esv7678CNV Loss19470904
    nsv213273CNV Loss16902084
    nsv876108CNV Loss21882294

    Human Gene Mutation Database (HGMD): NDUFA10
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDUFA10
    DNA2.0 Custom Variant and Variant Library Synthesis for NDUFA10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603835   
    OMIM disorders: 256000  
    3 diseases for NDUFA10:    
    About MalaCards
    leigh syndrome with leukodystrophy    leigh disease    mitochondrial dna deletion syndromes

    1 disease from the University of Copenhagen DISEASES database for NDUFA10:
    Leigh disease

    Find genes that share disorders with NDUFA10           About GenesLikeMe

    Genetic Association Database (GAD): NDUFA10
    Human Genome Epidemiology (HuGE) Navigator: NDUFA10 (5 documents)

    Export disorders for NDUFA10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NDUFA10 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with NDUFA10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2, 3 Loeffen J.L.C.M.... Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    4. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1, 4 Starr J.M....Deary I.J. (Mech. Ageing Dev. 2008)
    5. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    6. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1, 4 Harris S.E....Deary I.J. (BMC Genet. 2007)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (J. Biol. Chem. 2003)
    9. Identification of regions associated with variation in sensitivity to food-related odors in the human genome. (PubMed id 23910658)1 McRae J.F....Newcomb R.D. (Curr. Biol. 2013)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4705 HGNC: 7684 AceView: NDUFA10 Ensembl:ENSG00000130414 euGenes: HUgn4705
    ECgene: NDUFA10 Kegg: 4705 H-InvDB: NDUFA10

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NDUFA10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NDUFA10 gene:
    Search GeneIP for patents involving NDUFA10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NDUFA10   OriGene RNAi products in human, mouse, rat for NDUFA10  
     OriGene qPCR primer pairs and template standards for NDUFA10   OriGene Protein Over-expression Lysate for NDUFA10  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NDUFA10  
     OriGene qSTAR qPCR primer pairs in human, mouse for NDUFA10   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NDUFA10   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NDUFA10   OriGene Custom Protein Services for NDUFA10  

     
     
     Block miRNA regulation of human, mouse, rat NDUFA10 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NDUFA10
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDUFA10 Predesigned siRNA for gene silencing in human, mouse, rat NDUFA10
     QuantiFast Probe-based Assays in human, mouse, rat NDUFA10 QuantiTect SYBR Green Assays in human, mouse, rat NDUFA10
     PCR Arrays including human, mouse, rat NDUFA10 Search Chromatin IP Primers for NDUFA10
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDUFA10  Search GeneGlobe Interaction Network for NDUFA10
     Regulatory tfbs in NDUFA10 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NDUFA10 GenScript cDNA clones with any tag delivered in your preferred vector for NDUFA10
     GenScript Custom Assay Services for NDUFA10 GenScript Custom overexpressing Cell Line Services for NDUFA10
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NDUFA10 (NDUAA)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NDUFA10
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NDUFA10 antibodies
     NDUFA10 proteins
     NDUFA10 lysates
     Antibodies for NDUFA10
     See all of Abcam's Antibodies, Kits and Proteins for NDUFA10
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for NDUFA10
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDUFA10
     SwitchGear 3'UTR luciferase reporter plasmids for NDUFA10
     SwitchGear Promoter luciferase reporter plasmids for NDUFA10
     ThermoFisher Antibody for NDUFA10
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDUFA10
     Browse compounds at ApexBio
     Search Addgene for plasmids for NDUFA10
      Search eBioscience for proteins for NDUFA10
      Search eBioscience for elisas for NDUFA10
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for NDUFA10
     antibodies-online antibodies for NDUFA10 (28 products)
     antibodies-online kits for NDUFA10 (5 products)
      Search antibodies-online for peptides for NDUFA10
     antibodies-online proteins for NDUFA10 (7 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NDUFA10 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4