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Aliases for NDUFA10 Gene

Aliases for NDUFA10 Gene

  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 10, 42kDa 2 3
  • NADH-Ubiquinone Oxidoreductase 42 KDa Subunit 3 4
  • Complex I 42kDa Subunit 2 3
  • CI-42KD 3 4
  • NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 10, Mitochondrial 3
  • NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 10 (42kD) 2
  • Complex I-42kD 4
  • CI-42k 3

External Ids for NDUFA10 Gene

Summaries for NDUFA10 Gene

Entrez Gene Summary for NDUFA10 Gene

  • The protein encoded by this gene belongs to the complex I 42kDA subunit family. Mammalian complex I is the first enzyme complex in the electron transport chain of mitochondria. It is composed of 45 different subunits. This protein is a component of the hydrophobic protein fraction and has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. [provided by RefSeq, Jul 2008]

GeneCards Summary for NDUFA10 Gene

NDUFA10 (NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 10, 42kDa) is a Protein Coding gene. Diseases associated with NDUFA10 include leigh syndrome with leukodystrophy and leigh syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include NADH dehydrogenase (ubiquinone) activity and phosphotransferase activity, alcohol group as acceptor.

UniProtKB/Swiss-Prot for NDUFA10 Gene

  • Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Wiki entry for NDUFA10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDUFA10 Gene

Genomics for NDUFA10 Gene

Genomic Location for NDUFA10 Gene

Start:
239,892,450 bp from pter
End:
240,025,402 bp from pter
Size:
132,953 bases
Orientation:
Minus strand

Genomic View for NDUFA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDUFA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDUFA10 Gene

Proteins for NDUFA10 Gene

  • Protein details for NDUFA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95299-NDUAA_HUMAN
    Recommended name:
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
    Protein Accession:
    O95299
    Secondary Accessions:
    • Q8WXC9

    Protein attributes for NDUFA10 Gene

    Size:
    355 amino acids
    Molecular mass:
    40751 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692; Note=Binds 1 FAD per subunit.;
    Quaternary structure:
    • Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.

    Alternative splice isoforms for NDUFA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDUFA10 Gene

Proteomics data for NDUFA10 Gene at MOPED

Post-translational modifications for NDUFA10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys48, Lys102, Lys243, Lys277, Lys280, Lys285, Lys338, and Lys350

Other Protein References for NDUFA10 Gene

No data available for DME Specific Peptides for NDUFA10 Gene

Domains for NDUFA10 Gene

Gene Families for NDUFA10 Gene

HGNC:
  • comI :Mitochondrial respiratory chain complex / Complex I

Protein Domains for NDUFA10 Gene

UniProtKB/Swiss-Prot:

NDUAA_HUMAN
Family:
  • Belongs to the complex I NDUFA10 subunit family.:
    • O95299
genes like me logo Genes that share domains with NDUFA10: view

Function for NDUFA10 Gene

Molecular function for NDUFA10 Gene

GENATLAS Biochemistry: NADH ubiquinone oxidoreductase 10 (Q reductase),42kDa,component alpha 10,hydrophobic fraction of the complex I,multisubunit enzyme of oxidative phosphorylation (OXPHOS),inner mitochondrial membrane
UniProtKB/Swiss-Prot Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone

Gene Ontology (GO) - Molecular Function for NDUFA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0008137 NADH dehydrogenase (ubiquinone) activity NAS 9878551
GO:0019206 nucleoside kinase activity IEA --
genes like me logo Genes that share ontologies with NDUFA10: view

Phenotypes for NDUFA10 Gene

GenomeRNAi human phenotypes for NDUFA10:
genes like me logo Genes that share phenotypes with NDUFA10: view

miRNA for NDUFA10 Gene

miRTarBase miRNAs that target NDUFA10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDUFA10 Gene

Localization for NDUFA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDUFA10 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDUFA10 Gene COMPARTMENTS Subcellular localization image for NDUFA10 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NDUFA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005747 mitochondrial respiratory chain complex I NAS 9878551
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with NDUFA10: view

Pathways for NDUFA10 Gene

genes like me logo Genes that share pathways with NDUFA10: view

Gene Ontology (GO) - Biological Process for NDUFA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006120 mitochondrial electron transport, NADH to ubiquinone NAS 9878551
GO:0006139 nucleobase-containing compound metabolic process --
GO:0009165 nucleotide biosynthetic process IEA --
GO:0022904 respiratory electron transport chain TAS --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with NDUFA10: view

Compounds for NDUFA10 Gene

(8) HMDB Compounds for NDUFA10 Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
Iron
  • Armco iron
7439-89-6
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
NADH
  • 1,4-Dihydronicotinamide adenine dinucleotide
58-68-4
QH2
  • CoQH2
56275-39-9

(1) Drugbank Compounds for NDUFA10 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with NDUFA10: view

Transcripts for NDUFA10 Gene

Unigene Clusters for NDUFA10 Gene

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA10 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9: -

Relevant External Links for NDUFA10 Gene

GeneLoc Exon Structure for
NDUFA10
ECgene alternative splicing isoforms for
NDUFA10

Expression for NDUFA10 Gene

mRNA expression in normal human tissues for NDUFA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDUFA10 Gene

SOURCE GeneReport for Unigene cluster for NDUFA10 Gene Hs.277677

genes like me logo Genes that share expressions with NDUFA10: view

Orthologs for NDUFA10 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDUFA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDUFA10 36
  • 99.15 (n)
  • 99.15 (a)
NDUFA10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDUFA10 36
  • 82.12 (n)
  • 79.88 (a)
NDUFA10 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC608244 36
  • 82.98 (n)
  • 80.85 (a)
NDUFA10 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndufa10 36
  • 79.06 (n)
  • 76.62 (a)
Ndufa10 16
Ndufa10 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDUFA10 37
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDUFA10 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndufa10 36
  • 77.84 (n)
  • 76.34 (a)
chicken
(Gallus gallus)
Aves NDUFA10 36
  • 65.21 (n)
  • 61.63 (a)
NDUFA10 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDUFA10 37
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25913 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ndufa10 36
  • 62.2 (n)
  • 59.45 (a)
Str.5172 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
ndufa10 36
  • 61.5 (n)
  • 55.49 (a)
ndufa10 37
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011130 36
  • 47.21 (n)
  • 36.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta ND42 36
  • 48.35 (n)
  • 38.02 (a)
ND42 37
  • 31 (a)
OneToOne
ND42 38
  • 35 (a)
worm
(Caenorhabditis elegans)
Secernentea nuo-4 36
  • 43.92 (n)
  • 35.45 (a)
nuo-4 37
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.645 37
  • 23 (a)
OneToOne
Species with no ortholog for NDUFA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDUFA10 Gene

ENSEMBL:
Gene Tree for NDUFA10 (if available)
TreeFam:
Gene Tree for NDUFA10 (if available)

Paralogs for NDUFA10 Gene

No data available for Paralogs for NDUFA10 Gene

Variants for NDUFA10 Gene

Sequence variations from dbSNP and Humsavar for NDUFA10 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs8369 -- 239,960,810(+) AGAGC(A/G)GCAGC utr-variant-3-prime, intron-variant
rs13848 Likely benign 240,007,349(+) GAATA(C/T)TGTAA reference, synonymous-codon
rs714219 -- 239,977,473(+) CTTCA(C/T)GCAGG intron-variant
rs714220 -- 239,977,434(+) GAGCA(G/T)GCTTC intron-variant
rs720771 -- 239,997,580(-) AGAGT(A/G)TATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDUFA10 Gene

Variant ID Type Subtype PubMed ID
nsv876099 CNV Gain 21882294
nsv876100 CNV Loss 21882294
nsv834584 CNV Gain 17160897
nsv876106 CNV Gain 21882294
nsv3235 CNV Insertion 18451855
nsv876108 CNV Loss 21882294
nsv876110 CNV Loss 21882294
nsv876111 CNV Gain 21882294
nsv215214 CNV Loss 16902084
nsv482061 CNV Gain 20164927
nsv213273 CNV Loss 16902084
nsv483047 CNV Loss 15286789
esv2721886 CNV Deletion 23290073
nsv525278 CNV Gain 19592680
nsv876112 CNV Loss 21882294
esv2423154 CNV Deletion 19546169
esv2166282 CNV Deletion 18987734
esv2721887 CNV Deletion 23290073
esv7678 CNV Loss 19470904
nsv214120 CNV Loss 16902084

Relevant External Links for NDUFA10 Gene

HapMap Linkage Disequilibrium report
NDUFA10
Human Gene Mutation Database (HGMD)
NDUFA10

Disorders for NDUFA10 Gene

(1) OMIM Diseases for NDUFA10 Gene (603835)

(1) University of Copenhagen DISEASES for NDUFA10 Gene

Relevant External Links for NDUFA10

Genetic Association Database (GAD)
NDUFA10
Human Genome Epidemiology (HuGE) Navigator
NDUFA10
genes like me logo Genes that share disorders with NDUFA10: view

No data available for UniProtKB/Swiss-Prot for NDUFA10 Gene

Publications for NDUFA10 Gene

  1. cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PMID: 9878551) Loeffen J.L.C.M. … Smeitink J.A.M. (Biochem. Biophys. Res. Commun. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PMID: 18977241) Starr J.M. … Deary I.J. (Mech. Ageing Dev. 2008) 3 49
  4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 49
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 49

Products for NDUFA10 Gene

  • antibodies-online proteins for NDUFA10
  • antibodies-online antibodies for NDUFA10
  • antibodies-online kits for NDUFA10

Sources for NDUFA10 Gene

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