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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDST4 Gene

protein-coding   GIFtS: 54
GCID: GC04M115748

N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl)...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 41 2     NHSST42
Glucosaminyl N-Deacetylase/N-Sulfotransferase 42 3     Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 42
NDST-42 3     EC 2.8.2.83
N-Heparan Sulfate Sulfotransferase 42 3     HSST43
N-HSST 42 3     

External Ids:    HGNC: 207791   Entrez Gene: 645792   Ensembl: ENSG000001386537   OMIM: 6150395   UniProtKB: Q9H3R13   

Export aliases for NDST4 gene to outside databases

Previous GC identifers: GC04M116169 GC04M116030 GC04M116207 GC04M116106 GC04M111482


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NDST4 Gene: 
NDST4 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4) is a protein-coding gene. Diseases associated with NDST4 include morquio syndrome b, and alcohol dependence, and among its related super-pathways are Glycosaminoglycan biosynthesis - heparan sulfate / heparin and Metabolic pathways. GO annotations related to this gene include [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
(GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
Has low deacetylase activity but high sulfotransferase activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDST4 gene promoter:
         GATA-3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   HNF-1A   GATA-1   GATA-2   SRY   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDST4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDST4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

NDST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDST4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M115748:  view genomic region     (about GC identifiers)

Start:
115,748,919 bp from pter      End:
116,035,032 bp from pter
Size:
286,114 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1 (See protein sequence)
Recommended Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4  
Size: 872 amino acids; 100716 Da
Subunit: Monomer (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Miscellaneous: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as
well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation
reactions, whereas other later on fill in or extend already modified heparan sulfate sequences

Explore the universe of human proteins at neXtProt for NDST4: NX_Q9H3R1

Explore proteomics data for NDST4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H3R1

  • NDST4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDST4 Protein Expression
    REFSEQ proteins: NP_072091.1  
    ENSEMBL proteins: 
     ENSP00000264363   ENSP00000423218  
    Reactome Protein details: Q9H3R1
    Human Recombinant Protein Products for NDST4: 
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    Novus Biologicals NDST4 Proteins
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    Cloud-Clone Corp. Proteins for NDST4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral to membrane IEA--

    NDST4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase
     IPR021930 Heparan_SO4_deacetylase

    Graphical View of Domain Structure for InterPro Entry Q9H3R1

    ProtoNet protein and cluster: Q9H3R1

    UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
    Similarity: Belongs to the sulfotransferase 1 family. NDST subfamily


    NDST4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDST4_HUMAN, Q9H3R1
    Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
    (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
    backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
    Has low deacetylase activity but high sulfotransferase activity (By similarity)
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-N-sulfoglucosamine

         Enzyme Number (IUBMB): EC 2.8.2.81

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0019213deacetylase activity IEA--
         
    NDST4 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NDST4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NDST4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDST4 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDST4 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.77
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Mucopolysaccharidoses0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS IV - Morquio syndrome B0.48
    MPS I - Hurler syndrome0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS IX - Natowicz syndrome0.48
    4Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.56
    HS-GAG biosynthesis0.56
    5Biological oxidations
    metapathway biotransformation0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NDST4
        heparan sulfate biosynthesis (late stages)
    metapathway biotransformation
    heparan sulfate biosynthesis

    5/18        Reactome Pathways for NDST4 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    HS-GAG biosynthesis
    MPS II - Hunter syndrome


    2         Kegg Pathways  (Kegg details for NDST4):
        Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    Metabolic pathways

    UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
    Pathway: Glycan metabolism; heparan sulfate biosynthesis
    Pathway: Glycan metabolism; heparin biosynthesis


    NDST4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDST4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for NDST4 (ENSP000002643634) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXT1ENSP000003674464STRING: ENSP00000367446
    EXT2ENSP000003426564STRING: ENSP00000342656
    HS3ST1ENSP000000025964STRING: ENSP00000002596
    HS3ST2ENSP000002613744STRING: ENSP00000261374
    HS3ST3A1ENSP000002841104STRING: ENSP00000284110
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015012heparan sulfate proteoglycan biosynthetic process IEA--
    GO:0030210heparin biosynthetic process IEA--

    NDST4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDST4

    Search CenterWatch for drugs/clinical trials and news about NDST4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDST4 gene: 
    NM_022569.1  

    Unigene Cluster for NDST4:

    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
    Hs.591700  [show with all ESTs]
    Unigene Representative Sequence: AB036429
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264363(uc003ibu.3 uc010imw.3) ENST00000504854 ENST00000514570

    miRNA
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    Additional mRNA sequence: 

    AB036429.1 AK289670.1 BC012326.1 BC113075.2 

    2 DOTS entries:

    DT.91744534  DT.101964574 

    24/26 AceView cDNA sequences (see all 26):

    BC012326 AB036429 NM_022569 CD631448 CD631436 CD631454 CD631446 CD631473 
    CD631458 CD631451 CD631464 CD631471 CD631461 CD631441 CD631459 CD631433 
    CD631465 BG195726 CD631450 CD631469 CD631456 CD631468 CD631443 CD631439 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NDST4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                          
    SP2:              -                                                                           


    ECgene alternative splicing isoforms for NDST4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDST4 expression in normal human tissues (normalized intensities)      NDST4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATCCAGC
    NDST4 Expression
    About this image


    NDST4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/midbrain/lateral wall   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
             brain/midbrain/lateral wall   
     
     Peripheral Nervous System (Nervous System)
             dorsal root ganglia   
     
     Testis (Reproductive System)

     -- (Nervous System)
             mouse/organ system/nervous system/central nervous system   

    See NDST4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDST4

    SOURCE GeneReport for Unigene cluster: Hs.591700
        SABiosciences Custom PCR Arrays for NDST4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDST4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NDST4 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndst41 , 5 N-deacetylase/N-sulfotransferase (heparin glucosaminyl) more1, 5 88.57(n)1
    95.87(a)1
      3 (54.68 cM)5
    645801  NM_022565.21  NP_072087.21 
     1254040945 
    chicken
    (Gallus gallus)
    Aves NDST41 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 81.42(n)
    89.33(a)
      422686  XM_420638.2  XP_420638.2 
    lizard
    (Anolis carolinensis)
    Reptilia NDST46
    Uncharacterized protein
    89(a)
    1 ↔ 1
    5(141849384-141965648)
    zebrafish
    (Danio rerio)
    Actinopterygii ndst31 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 68.85(n)
    76.46(a)
      100317129  XM_002660424.2  XP_002660470.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sfl3 cell surface receptor linked signal
    transduction more
    53(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea hst-13 N-heparan sulfate sulfotransferase 44(a)   IV(8688631-8691631)   --


    ENSEMBL Gene Tree for NDST4 (if available)
    TreeFam Gene Tree for NDST4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDST4 gene
    HS3ST22  ZSWIM8-AS12  HS3ST12  HS3ST3B12  HS3ST42  HS3ST62  HS3ST52  HS3ST3A12  
    NDST12  NDST32  
    8 SIMAP similar genes for NDST4 using alignment to 2 protein entries:     NDST4_HUMAN (see all proteins):
    NDST3    NDST2    NDST1    AURA2    NF2    FAM175A
    HS3ST4    HS3ST1

    NDST4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6061 SNPs in NDST4 are shown (see all 6061)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs675133361,2
    C--111738034(+) GAAAC-/AAAGATT 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs561892081,2
    C--115629337(+) CCAAG-/A/AA/A
    AAAAAAAA
    AAAAA
    1 -- int10--------
    rs1484806591,2
    --115748516(+) GTTACA/TTAATT 1 -- int10--------
    rs1865744591,2
    --115748545(+) AAAATC/TGTTTT 1 -- int10--------
    rs1177073961,2
    C,F--115748599(+) AGTTAC/TGACTA 1 -- int11Minor allele frequency- T:0.04EA 120
    rs738484631,2
    C,F--115748640(+) TTAACT/CGCTCA 1 -- int12Minor allele frequency- C:0.11WA 120
    rs1417547441,2
    --115748649(+) CACTTG/TTATAT 1 -- int10--------
    rs726797481,2
    C,F--115748796(+) GATTGG/ATGCTA 1 -- int16Minor allele frequency- A:0.17CSA WA NA EA 367
    rs1885577441,2
    --115748850(+) AAAAGC/GCTGAA 1 -- int10--------
    rs1125019491,2
    C--115748914(+) GATTT-/T/TT  
            
    ATTTT
    1 -- int11CSA 2

    HapMap Linkage Disequilibrium report for NDST4 (115748919 - 115998919 bp, first 250kb of NDST4)

    Structural Variations
         Database of Genomic Variants (DGV) 10/36 variations for NDST4 (see all 36):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2728176CNV Deletion23290073
    esv2728177CNV Deletion23290073
    esv2728183CNV Deletion23290073
    esv2728179CNV Deletion23290073
    esv1983936CNV Deletion18987734
    esv2659955CNV Deletion23128226
    esv2728181CNV Deletion23290073
    nsv820612CNV Deletion20802225
    nsv435800CNV Deletion17901297
    esv1499242CNV Deletion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615039    OMIM disorders: --

    3 diseases for NDST4:    About MalaCards
    morquio syndrome b    alcohol dependence    alcoholism


    NDST4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NDST4
    Human Genome Epidemiology (HuGE) Navigator: NDST4 (2 documents)

    Export disorders for NDST4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDST4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NDST4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple isozymes of heparan sulfate/heparin GlcNAc N- deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. (PubMed id 11087757)1, 2, 3, 9 Aikawa J.... Esko J.D. (2001)
    2. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PubMed id 22843503)1 Qi Q....Qi L. (2012)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64579 HGNC: 20779 AceView: NDST4 Ensembl:ENSG00000138653 euGenes: HUgn64579
    ECgene: NDST4 Kegg: 64579 H-InvDB: NDST4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDST4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NDST4 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDST4 gene:
    Search GeneIP for patents involving NDST4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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