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Aliases for NDST4 Gene

Aliases for NDST4 Gene

  • N-Deacetylase And N-Sulfotransferase 4 2 3
  • N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 4 2 3
  • Glucosaminyl N-Deacetylase/N-Sulfotransferase 4 3 4
  • N-Heparan Sulfate Sulfotransferase 4 3 4
  • N-Deacetylase/N-Sulfotransferase 4 3 5
  • N-HSST 4 3 4
  • NDST-4 3 4
  • Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 4 3
  • EC 2.8.2.8 4
  • N-HSST 3
  • NHSST4 3
  • HSST4 4

External Ids for NDST4 Gene

Previous GeneCards Identifiers for NDST4 Gene

  • GC04M116169
  • GC04M116030
  • GC04M116207
  • GC04M116106
  • GC04M115748
  • GC04M111482

Summaries for NDST4 Gene

GeneCards Summary for NDST4 Gene

NDST4 (N-Deacetylase And N-Sulfotransferase 4) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and Glycosaminoglycan metabolism. GO annotations related to this gene include hydrolase activity and deacetylase activity. An important paralog of this gene is NDST3.

UniProtKB/Swiss-Prot for NDST4 Gene

  • Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDST4 Gene

Genomics for NDST4 Gene

Regulatory Elements for NDST4 Gene

Enhancers for NDST4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NDST4 on UCSC Golden Path with GeneCards custom track

Promoters for NDST4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDST4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDST4 Gene

Chromosome:
4
Start:
114,827,763 bp from pter
End:
115,113,876 bp from pter
Size:
286,114 bases
Orientation:
Minus strand

Genomic View for NDST4 Gene

Genes around NDST4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDST4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDST4 Gene

Proteins for NDST4 Gene

  • Protein details for NDST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3R1-NDST4_HUMAN
    Recommended name:
    Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
    Protein Accession:
    Q9H3R1
    Secondary Accessions:
    • Q2KHM8

    Protein attributes for NDST4 Gene

    Size:
    872 amino acids
    Molecular mass:
    100716 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.

    Alternative splice isoforms for NDST4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDST4 Gene

Post-translational modifications for NDST4 Gene

  • Glycosylation at Asn 226, Asn 341, Asn 391, Asn 657, and Asn 793
  • Modification sites at PhosphoSitePlus

Other Protein References for NDST4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDST4 Gene

Domains & Families for NDST4 Gene

Gene Families for NDST4 Gene

Protein Domains for NDST4 Gene

Suggested Antigen Peptide Sequences for NDST4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3R1

UniProtKB/Swiss-Prot:

NDST4_HUMAN :
  • Belongs to the sulfotransferase 1 family. NDST subfamily.
Family:
  • Belongs to the sulfotransferase 1 family. NDST subfamily.
genes like me logo Genes that share domains with NDST4: view

Function for NDST4 Gene

Molecular function for NDST4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.
UniProtKB/Swiss-Prot Function:
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).

Enzyme Numbers (IUBMB) for NDST4 Gene

Gene Ontology (GO) - Molecular Function for NDST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity IEA --
GO:0019213 deacetylase activity IEA --
genes like me logo Genes that share ontologies with NDST4: view
genes like me logo Genes that share phenotypes with NDST4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NDST4

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDST4 Gene

Localization for NDST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDST4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDST4 Gene COMPARTMENTS Subcellular localization image for NDST4 gene
Compartment Confidence
golgi apparatus 4
endoplasmic reticulum 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NDST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDST4: view

Pathways & Interactions for NDST4 Gene

genes like me logo Genes that share pathways with NDST4: view

UniProtKB/Swiss-Prot Q9H3R1-NDST4_HUMAN

  • Pathway: Glycan metabolism; heparan sulfate biosynthesis.
  • Pathway: Glycan metabolism; heparin biosynthesis.

Interacting Proteins for NDST4 Gene

Gene Ontology (GO) - Biological Process for NDST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015012 heparan sulfate proteoglycan biosynthetic process IEA --
GO:0030210 heparin biosynthetic process IEA --
genes like me logo Genes that share ontologies with NDST4: view

No data available for SIGNOR curated interactions for NDST4 Gene

Drugs & Compounds for NDST4 Gene

(2) Additional Compounds for NDST4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with NDST4: view

Transcripts for NDST4 Gene

Unigene Clusters for NDST4 Gene

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDST4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -

Relevant External Links for NDST4 Gene

GeneLoc Exon Structure for
NDST4
ECgene alternative splicing isoforms for
NDST4

Expression for NDST4 Gene

mRNA expression in normal human tissues for NDST4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDST4 Gene

This gene is overexpressed in Brain - Hypothalamus (x6.4), Brain - Substantia nigra (x4.7), and Prostate (x4.2).

Protein differential expression in normal tissues from HIPED for NDST4 Gene

This gene is overexpressed in Liver (53.2) and Plasma (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NDST4 Gene



Protein tissue co-expression partners for NDST4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NDST4 Gene:

NDST4

SOURCE GeneReport for Unigene cluster for NDST4 Gene:

Hs.591700
genes like me logo Genes that share expression patterns with NDST4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NDST4 Gene

Orthologs for NDST4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDST4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDST4 34
  • 93.39 (n)
  • 97.94 (a)
NDST4 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDST4 34
  • 93.16 (n)
  • 97.48 (a)
NDST4 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndst4 34
  • 88.57 (n)
  • 95.87 (a)
Ndst4 16
Ndst4 35
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDST4 34
  • 99.46 (n)
  • 99.31 (a)
NDST4 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndst4 34
  • 87.88 (n)
  • 95.87 (a)
oppossum
(Monodelphis domestica)
Mammalia NDST4 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDST4 35
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDST4 34
  • 81.27 (n)
  • 89.22 (a)
NDST4 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDST4 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndst4 34
  • 76.49 (n)
  • 84.52 (a)
zebrafish
(Danio rerio)
Actinopterygii ndst3 34
  • 68.92 (n)
  • 76.46 (a)
ndst3 35
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sfl 36
  • 53 (a)
sfl 35
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hst-1 36
  • 44 (a)
hst-1 35
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToMany
Species where no ortholog for NDST4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDST4 Gene

ENSEMBL:
Gene Tree for NDST4 (if available)
TreeFam:
Gene Tree for NDST4 (if available)

Paralogs for NDST4 Gene

(8) SIMAP similar genes for NDST4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NDST4: view

Variants for NDST4 Gene

Sequence variations from dbSNP and Humsavar for NDST4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs35181627 - 115,077,002(+) ATGTT(C/T)GAAAA reference, missense
rs279505 -- 114,990,857(-) GGTGC(A/G)TTAAA intron-variant
rs279506 -- 114,991,575(+) GACAT(G/T)CCTGG intron-variant
rs279507 -- 114,993,856(+) GATTC(A/G)TAAGT intron-variant
rs279508 -- 114,994,199(+) AAATA(C/T)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDST4 Gene

Variant ID Type Subtype PubMed ID
dgv150n73 CNV deletion 24416366
dgv9232n54 CNV loss 21841781
dgv9233n54 CNV loss 21841781
dgv9234n54 CNV loss 21841781
dgv9235n54 CNV gain 21841781
dgv9236n54 CNV loss 21841781
dgv9237n54 CNV gain+loss 21841781
dgv9238n54 CNV gain 21841781
esv1002972 CNV gain 20482838
esv1499242 CNV deletion 17803354
esv1983936 CNV deletion 18987734
esv2266453 CNV deletion 18987734
esv2570638 CNV deletion 19546169
esv25921 CNV gain+loss 19812545
esv2659955 CNV deletion 23128226
esv2728176 CNV deletion 23290073
esv2728177 CNV deletion 23290073
esv2728178 CNV deletion 23290073
esv2728179 CNV deletion 23290073
esv2728180 CNV deletion 23290073
esv2728181 CNV deletion 23290073
esv2728182 CNV deletion 23290073
esv2728183 CNV deletion 23290073
esv3439143 CNV insertion 20981092
esv3564468 CNV deletion 23714750
esv3564470 CNV deletion 23714750
esv3569668 CNV loss 25503493
esv3601843 CNV loss 21293372
esv3601846 CNV loss 21293372
esv3601847 CNV loss 21293372
esv3601849 CNV loss 21293372
esv3601850 CNV loss 21293372
esv3894008 CNV loss 25118596
esv5057 CNV loss 18987735
nsv1000544 CNV loss 25217958
nsv1078540 CNV duplication 25765185
nsv1125821 CNV tandem duplication 24896259
nsv1147717 CNV deletion 26484159
nsv1148021 CNV deletion 26484159
nsv290603 CNV deletion 16902084
nsv292358 CNV deletion 16902084
nsv435800 CNV deletion 17901297
nsv4480 CNV deletion 18451855
nsv461623 CNV gain 19166990
nsv511239 CNV loss 21212237
nsv595228 CNV gain 21841781
nsv595232 CNV loss 21841781
nsv595254 CNV gain 21841781
nsv820612 CNV deletion 20802225
nsv822693 CNV loss 20364138
nsv822694 CNV loss 20364138
nsv830040 CNV gain 17160897
nsv830041 CNV gain 17160897
nsv955824 CNV deletion 24416366

Variation tolerance for NDST4 Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDST4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDST4 Gene

Disorders for NDST4 Gene

Relevant External Links for NDST4

Genetic Association Database (GAD)
NDST4
Human Genome Epidemiology (HuGE) Navigator
NDST4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDST4

No disorders were found for NDST4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDST4 Gene

Publications for NDST4 Gene

  1. Multiple isozymes of heparan sulfate/heparin GlcNAc N- deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. (PMID: 11087757) Aikawa J. … Esko J.D. (J. Biol. Chem. 2001) 2 3 4 22 65
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 46 65
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  4. NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer. (PMID: 23825612) Tzeng S.T. … Yang Y.C. (PLoS ONE 2013) 3 65
  5. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PMID: 23897914) Wang H. … O'Brodovich H.M. (Pediatrics 2013) 3 65

Products for NDST4 Gene

Sources for NDST4 Gene

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