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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDST4 Gene

protein-coding   GIFtS: 53
GCID: GC04M115748

N-deacetylase/N-sulfotransferase (heparan glucosaminyl)...
 Explore 3 diseases affiliated with
NDST4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NDST4    

Aliases
for NDST4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 41 2     NHSST42
Glucosaminyl N-Deacetylase/N-Sulfotransferase 42 3     Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 42
NDST-42 3     EC 2.8.2.83
N-Heparan Sulfate Sulfotransferase 42 3     HSST43
N-HSST 42 3     

External Ids:    HGNC: 207791   Entrez Gene: 645792   Ensembl: ENSG000001386537   OMIM: 6150395   UniProtKB: Q9H3R13   

Export aliases for NDST4 gene to outside databases

Previous GC identifers: GC04M116169 GC04M116030 GC04M116207 GC04M116106 GC04M111482


Summaries
for NDST4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
(GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone
to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low
deacetylase activity but high sulfotransferase activity (By similarity)




Genomic Views
for NDST4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDST4 gene promoter:
         GATA-3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   HNF-1A   GATA-1   GATA-2   SRY   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NDST4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDST4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

NDST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDST4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M115748:  view genomic region     (about GC identifiers)

Start:
 115,748,919 bp from pter      End:
 116,035,032 bp from pter
Size:
 286,114 bases      Orientation:
 minus strand

Proteins
for NDST4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1 (See protein sequence)
Recommended Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4  
Size: 872 amino acids; 100716 Da
Subunit: Monomer (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Miscellaneous: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well
as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions,
whereas other later on fill in or extend already modified heparan sulfate sequences

Explore the universe of human proteins at neXtProt for NDST4: NX_Q9H3R1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H3R1

    • NDST4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_072091.1  
    ENSEMBL proteins: 
     ENSP00000264363   ENSP00000423218  
    Reactome Protein details: Q9H3R1
    Human Recombinant Protein Products: 
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    Novus Biologicals NDST4 Proteins
    Novus Biologicals NDST4 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NDST4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral to membrane IEA--


    NDST4 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NDST4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NDST4 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR021930 Heparan_SO4_deacetylase
     IPR000863 Sulfotransferase_dom

    Graphical View of Domain Structure for InterPro Entry Q9H3R1

    ProtoNet protein and cluster: Q9H3R1

    UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
    Similarity: Belongs to the sulfotransferase 1 family. NDST subfamily


    Function
    for NDST4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
    Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
    (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone
    to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low
    deacetylase activity but high sulfotransferase activity (By similarity)
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-N-sulfoglucosamine

    Enzyme Number (IUBMB): EC 2.8.2.81

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: NDST4
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0019213deacetylase activity IEA--


    NDST4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NDST4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1MPS IIIC - Sanfilippo syndrome C
    8/16 pathways (see all 16)
    		MPS VI - Maroteaux-Lamy syndrome1.00
    		MPS IIIA - Sanfilippo syndrome A1.00
    		MPS IIIC - Sanfilippo syndrome C1.00
    		MPS IIID - Sanfilippo syndrome D1.00
    		MPS I - Hurler syndrome1.00
    		MPS IX - Natowicz syndrome1.00
    		Mucopolysaccharidoses1.00
    		MPS II - Hunter syndrome1.00
    2heparan sulfate biosynthesis
    		heparan sulfate biosynthesis1.00
    		heparan sulfate biosynthesis (late stages)0.78
    		Glycosaminoglycan biosynthesis - heparan sulfate0.83
    3Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    4Disease
    		Disease1.00
    5Biological oxidations
    		metapathway biotransformation0.41

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 BioSystems Pathways for NDST4 
        heparan sulfate biosynthesis (late stages)
    heparan sulfate biosynthesis
    metapathway biotransformation

    5/18        Reactome Pathways for NDST4 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    HS-GAG biosynthesis
    MPS II - Hunter syndrome


    2         Kegg Pathways  (Kegg details for NDST4):
        Glycosaminoglycan biosynthesis - heparan sulfate
    Metabolic pathways

    UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
    Pathway: Glycan metabolism; heparan sulfate biosynthesis
    Pathway: Glycan metabolism; heparin biosynthesis


    NDST4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDST4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/10 Interacting proteins for NDST4 (ENSP000002643634) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXT1ENSP000003674464STRING: ENSP00000367446
    EXT2ENSP000003426564STRING: ENSP00000342656
    HS3ST1ENSP000000025964STRING: ENSP00000002596
    HS3ST2ENSP000002613744STRING: ENSP00000261374
    HS3ST3A1ENSP000002841104STRING: ENSP00000284110
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015012heparan sulfate proteoglycan biosynthetic process IEA--
    GO:0030210heparin biosynthetic process IEA--


    NDST4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NDST4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDST4
    Search CenterWatch for drugs/clinical trials and news about NDST4 

    Transcripts
    for NDST4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NDST4 gene: 
    NM_022569.1  

    Unigene Cluster for NDST4:

    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
    Hs.591700  [show with all ESTs]
    Unigene Representative Sequence: AB036429
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264363(uc003ibu.3 uc010imw.3) ENST00000504854 ENST00000514570


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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB036429.1 AK289670.1 BC012326.1 BC113075.2 

    2 DOTS entries:

    DT.91744534  DT.101964574 

    24/26 AceView cDNA sequences (see all 26):

    AB036429 NM_022569 BC012326 CD631454 CD631458 CD631446 CD631448 CD631473 
    CD631436 CD631451 CD631461 CD631450 CD631469 BG195726 CD631468 CD631459 
    CD631464 CD631433 CD631471 CD631456 CD631465 CD631441 CD631437 CD631439 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NDST4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                          
    SP2:              -                                                                           


    ECgene alternative splicing isoforms for NDST4

    Expression
    for NDST4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDST4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGATCCAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NDST4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NDST4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDST4

    SOURCE GeneReport for Unigene cluster: Hs.591700
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    In Situ
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    Orthologs
    for NDST4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NDST4 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NDST41 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 81.42(n)
    89.33(a)    		   422686  XM_420638.2  XP_420638.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NDST46
    		 --
    		 89(a)
    		 1 ↔ 1
    		 5(141849651-141965648)
    zebrafish
    (Danio rerio)    		 Actinopterygii ndst31 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 68.85(n)
    76.46(a)    		   100317129  XM_002660424.2  XP_002660470.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sfl3 cell surface receptor linked signal
    transduction more    		 53(a)     --


    ENSEMBL Gene Tree for NDST4 (if available)
    TreeFam Gene Tree for NDST4 (if available) 

    Paralogs
    for NDST4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDST4 gene
    HS3ST22  HS3ST12  NDST22  HS3ST3B12  HS3ST42  HS3ST62  HS3ST3A12  HS3ST52  
    NDST12  NDST32  
    8 SIMAP similar genes for NDST4 using alignment to 2 protein entries:     NDST4_HUMAN (see all proteins):
    NDST3    NDST2    NDST1    AURA2    NF2    FAM175A
    HS3ST4    HS3ST1

    NDST4 for paralogs           About GeneDecksing



    Genomic Variants
    for NDST4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 14 variations for NDST4
         4 CNVs: 92333 98857 63935 23042
         10 Indels: 80443 92331 46488 41364 92330 92334 80442 46487 92332 12532
    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NDST4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NDST4 for disorders           About GeneDecksing

    OMIM gene information: 615039    OMIM disorders: --

    3 diseases for NDST4:    About MalaCards
    alcohol dependence    hermaphroditism    alcoholism

    Human Genome Epidemiology (HuGE) Navigator: NDST4 (2 documents)

    Export disorders for NDST4 gene to outside databases

    Publications
    for NDST4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDST4 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NDST4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple isozymes of heparan sulfate/heparin GlcNAc N- deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. (PubMed id 11087757)1, 2, 3, 9 Aikawa J.... Esko J.D. (2001)
    2. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PubMed id 22843503)1 Qi Q....Qi L. (2012)
    3. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for NDST4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NDST4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64579 HGNC: 20779 AceView: NDST4 Ensembl:ENSG00000138653 euGenes: HUgn64579
    ECgene: NDST4 Kegg: 64579 H-InvDB: NDST4

    Other Databases showing NDST4 gene

    (According to HUGE)
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    Specialized Databases showing NDST4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDST4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NDST4 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    Intellectual Property
    for NDST4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NDST4 gene:
    Search GeneIP for patents involving NDST4

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