Aliases for NDST4 Gene
External Ids for NDST4 Gene
Previous GeneCards Identifiers for NDST4 Gene
GeneCards Summary for NDST4 Gene
NDST4 (N-Deacetylase/N-Sulfotransferase 4) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and Glycosaminoglycan metabolism. GO annotations related to this gene include hydrolase activity and deacetylase activity. An important paralog of this gene is HS3ST5.
UniProtKB/Swiss-Prot for NDST4 Gene
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).