Aliases for NDST4 Gene
External Ids for NDST4 Gene
Previous GeneCards Identifiers for NDST4 Gene
GeneCards Summary for NDST4 Gene
NDST4 (N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 4) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include deacetylase activity and [heparan sulfate]-glucosamine N-sulfotransferase activity. An important paralog of this gene is HS3ST5.
UniProtKB/Swiss-Prot for NDST4 Gene
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).