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NDST4 Gene

protein-coding   GIFtS: 53
GCID: GC04M115748

N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl)...

  Search for NDST4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 41 2     NHSST42
Glucosaminyl N-Deacetylase/N-Sulfotransferase 42 3     Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 42
NDST-42 3     EC 2.8.2.83
N-Heparan Sulfate Sulfotransferase 42 3     HSST43
N-HSST 42 3     

External Ids:    HGNC: 207791   Entrez Gene: 645792   Ensembl: ENSG000001386537   OMIM: 6150395   UniProtKB: Q9H3R13   

Export aliases for NDST4 gene to outside databases

Previous GC identifers: GC04M116169 GC04M116030 GC04M116207 GC04M116106 GC04M111482


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NDST4 Gene:
NDST4 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4) is a protein-coding gene. GO annotations related to this gene include [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
(GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
Has low deacetylase activity but high sulfotransferase activity (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDST4 gene promoter:
         GATA-3   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   HNF-1A   GATA-1   GATA-2   SRY   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDST4 promoter sequence
   Search Chromatin IP Primers for NDST4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDST4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

NDST4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDST4 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M115748:  view genomic region     (about GC identifiers)

Start:
115,748,919 bp from pter      End:
116,035,032 bp from pter
Size:
286,114 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1 (See protein sequence)
Recommended Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4  
Size: 872 amino acids; 100716 Da
Subunit: Monomer (By similarity)
Miscellaneous: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as
well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation
reactions, whereas other later on fill in or extend already modified heparan sulfate sequences

Explore the universe of human proteins at neXtProt for NDST4: NX_Q9H3R1

Explore proteomics data for NDST4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn226, Asn341, Asn391, Asn657, Asn793
  • Modification sites at PhosphoSitePlus

  • See NDST4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_072091.1  
    ENSEMBL proteins: 
     ENSP00000264363   ENSP00000423218  
    Reactome Protein details: Q9H3R1

    NDST4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase
     IPR021930 Heparan_SO4_deacetylase

    Graphical View of Domain Structure for InterPro Entry Q9H3R1

    ProtoNet protein and cluster: Q9H3R1

    UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
    Similarity: Belongs to the sulfotransferase 1 family. NDST subfamily


    Find genes that share domains with NDST4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDST4_HUMAN, Q9H3R1
    Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
    (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
    backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
    Has low deacetylase activity but high sulfotransferase activity (By similarity)
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-N-sulfoglucosamine

         Enzyme Number (IUBMB): EC 2.8.2.81

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0019213deacetylase activity IEA--
         
    Find genes that share ontologies with NDST4           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDST4
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDST4_HUMAN, Q9H3R1: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum2
    extracellular1
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with NDST4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDST4 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.00
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    4Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG biosynthesis0.57
    5Biological oxidations
    metapathway biotransformation0.42


    Find genes that share SuperPaths with NDST4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NDST4
        heparan sulfate biosynthesis (late stages)
    metapathway biotransformation
    heparan sulfate biosynthesis

    1 Reactome Pathway for NDST4
        HS-GAG biosynthesis


    2 Kegg Pathways  (Kegg details for NDST4):
        Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    Metabolic pathways

    UniProtKB/Swiss-Prot: NDST4_HUMAN, Q9H3R1
    Pathway: Glycan metabolism; heparan sulfate biosynthesis
    Pathway: Glycan metabolism; heparin biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDST4
    Interactions:

        Search GeneGlobe Interaction Network for NDST4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for NDST4 (ENSP000002643634) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HS3ST1ENSP000000025964STRING: ENSP00000002596
    HS3ST2ENSP000002613744STRING: ENSP00000261374
    HS3ST3A1ENSP000002841104STRING: ENSP00000284110
    HS6ST1ENSP000002592414STRING: ENSP00000259241
    HS6ST3ENSP000003658954STRING: ENSP00000365895
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015012heparan sulfate proteoglycan biosynthetic process IEA--
    GO:0030210heparin biosynthetic process IEA--

    Find genes that share ontologies with NDST4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDST4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDST4 gene: 
    NM_022569.1  

    Unigene Cluster for NDST4:

    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
    Hs.591700  [show with all ESTs]
    Unigene Representative Sequence: AB036429
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264363(uc003ibu.3 uc010imw.3) ENST00000504854 ENST00000514570

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NDST4
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      QuantiFast Probe-based Assays in human, mouse, rat NDST4

    Additional mRNA sequence: 

    AB036429.1 AK289670.1 BC012326.1 BC113075.2 

    2 DOTS entries:

    DT.91744534  DT.101964574 

    Selected AceView cDNA sequences (see all 26):

    AB036429 NM_022569 BC012326 CD631458 CD631446 CD631454 CD631473 CD631436 
    CD631448 CD631468 CD631461 CD631459 CD631433 CD631456 CD631465 CD631464 
    BG195726 CD631441 CD631469 CD631471 CD631450 CD631451 CD631439 CD631443 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NDST4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                                          
    SP2:              -                                                                           


    ECgene alternative splicing isoforms for NDST4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDST4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGATCCAGC
    NDST4 Expression
    About this image


    NDST4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Testis (Reproductive System)
    NDST4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDST4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591700
        Custom PCR Arrays for NDST4
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDST4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndst41 , 5 N-deacetylase/N-sulfotransferase (heparin glucosaminyl) more1, 5 88.57(n)1
    95.87(a)1
      3 (54.68 cM)5
    645801  NM_022565.21  NP_072087.21 
     1254040945 
    chicken
    (Gallus gallus)
    Aves NDST41 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 81.27(n)
    89.22(a)
      422686  XM_420638.3  XP_420638.2 
    lizard
    (Anolis carolinensis)
    Reptilia NDST46
    N-deacetylase/N-sulfotransferase (heparan glucosam...
    89(a)
    1 ↔ 1
    5(141849384-141965648)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ndst41 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 76.49(n)
    84.52(a)
      100380006  XM_002934247.2  XP_002934293.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndst31 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 68.92(n)
    76.46(a)
      100317129  XM_002660424.3  XP_002660470.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sfl3 cell surface receptor linked signal
    transduction more
    53(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea hst-13 N-heparan sulfate sulfotransferase 44(a)   IV(8688631-8691631)   --


    ENSEMBL Gene Tree for NDST4 (if available)
    TreeFam Gene Tree for NDST4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDST4 gene
    HS3ST22  NDST22  ENSG000002729162  HS3ST12  HS3ST3B12  HS3ST42  HS3ST62  HS3ST3A12  
    HS3ST52  NDST12  NDST32  
    8 SIMAP similar genes for NDST4 using alignment to 2 protein entries:     NDST4_HUMAN (see all proteins):
    NDST3    NDST2    NDST1    AURA2    NF2    FAM175A
    HS3ST4    HS3ST1

    Find genes that share paralogs with NDST4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDST4 (see all 6061)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs675133361,2
    C--111738034(+) GAAAC-/AAAGATT 1 -- int11Minor allele frequency- AA:0.00NA 2
    rs561892081,2
    C--115629337(+) CCAAG-/A/AA/A
    AAAAAAAA
    AAAAA
    1 -- int10--------
    rs1484806591,2
    --115748516(+) GTTACA/TTAATT 1 -- int10--------
    rs1865744591,2
    --115748545(+) AAAATC/TGTTTT 1 -- int10--------
    rs1177073961,2
    C,F--115748599(+) AGTTAC/TGACTA 1 -- int11Minor allele frequency- T:0.04EA 120
    rs738484631,2
    C,F--115748640(+) TTAACT/CGCTCA 1 -- int12Minor allele frequency- C:0.11WA 120
    rs1417547441,2
    --115748649(+) CACTTG/TTATAT 1 -- int10--------
    rs726797481,2
    C,F--115748796(+) GATTGG/ATGCTA 1 -- int16Minor allele frequency- A:0.17CSA WA NA EA 367
    rs1885577441,2
    --115748850(+) AAAAGC/GCTGAA 1 -- int10--------
    rs1125019491,2
    C--115748914(+) GATTT-/T/TT  
            
    ATTTT
    1 -- int11CSA 2

    HapMap Linkage Disequilibrium report for NDST4 (115748919 - 115998919 bp, first 250kb of NDST4)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NDST4 (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728176CNV Deletion23290073
    esv2728177CNV Deletion23290073
    esv2728183CNV Deletion23290073
    esv2728179CNV Deletion23290073
    esv1983936CNV Deletion18987734
    esv2659955CNV Deletion23128226
    esv2728181CNV Deletion23290073
    nsv820612CNV Deletion20802225
    nsv435800CNV Deletion17901297
    esv1499242CNV Deletion17803354

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615039    OMIM disorders: --


    Find genes that share disorders with NDST4           About GenesLikeMe

    Genetic Association Database (GAD): NDST4
    Human Genome Epidemiology (HuGE) Navigator: NDST4 (2 documents)

    Export disorders for NDST4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDST4 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with NDST4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple isozymes of heparan sulfate/heparin GlcNAc N- deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. (PubMed id 11087757)1, 2, 3, 9 Aikawa J.... Esko J.D. (J. Biol. Chem. 2001)
    2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. (PubMed id 23897914)1 Wang H....O'Brodovich H.M. (Pediatrics 2013)
    5. NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer. (PubMed id 23825612)1 Tzeng S.T....Yang Y.C. (PLoS ONE 2013)
    6. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PubMed id 22843503)1 Qi Q....Qi L. (Hum. Mol. Genet. 2012)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64579 HGNC: 20779 AceView: NDST4 Ensembl:ENSG00000138653 euGenes: HUgn64579
    ECgene: NDST4 Kegg: 64579 H-InvDB: NDST4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDST4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NDST4 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=NDST4

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDST4 gene:
    Search GeneIP for patents involving NDST4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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