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Aliases for NDST4 Gene

Aliases for NDST4 Gene

  • N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 4 2 3
  • Glucosaminyl N-Deacetylase/N-Sulfotransferase 4 3 4
  • N-Heparan Sulfate Sulfotransferase 4 3 4
  • N-HSST 4 3 4
  • NDST-4 3 4
  • Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 4 3
  • EC 2.8.2.8 4
  • NHSST4 3
  • HSST4 4

External Ids for NDST4 Gene

Previous GeneCards Identifiers for NDST4 Gene

  • GC04M116169
  • GC04M116030
  • GC04M116207
  • GC04M116106
  • GC04M115748
  • GC04M111482

Summaries for NDST4 Gene

GeneCards Summary for NDST4 Gene

NDST4 (N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 4) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include deacetylase activity and [heparan sulfate]-glucosamine N-sulfotransferase activity. An important paralog of this gene is HS3ST5.

UniProtKB/Swiss-Prot for NDST4 Gene

  • Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDST4 Gene

Genomics for NDST4 Gene

Regulatory Elements for NDST4 Gene

Genomic Location for NDST4 Gene

Start:
114,827,763 bp from pter
End:
115,113,876 bp from pter
Size:
286,114 bases
Orientation:
Minus strand

Genomic View for NDST4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDST4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDST4 Gene

Proteins for NDST4 Gene

  • Protein details for NDST4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3R1-NDST4_HUMAN
    Recommended name:
    Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4
    Protein Accession:
    Q9H3R1
    Secondary Accessions:
    • Q2KHM8

    Protein attributes for NDST4 Gene

    Size:
    872 amino acids
    Molecular mass:
    100716 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences

    Alternative splice isoforms for NDST4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDST4 Gene

Proteomics data for NDST4 Gene at MOPED

Post-translational modifications for NDST4 Gene

  • Glycosylation at Asn226, Asn341, Asn391, Asn657, and Asn793
  • Modification sites at PhosphoSitePlus

Other Protein References for NDST4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NDST4 Gene

Domains for NDST4 Gene

Gene Families for NDST4 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for NDST4 Gene

Suggested Antigen Peptide Sequences for NDST4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3R1

UniProtKB/Swiss-Prot:

NDST4_HUMAN :
  • Q9H3R1
Family:
  • Belongs to the sulfotransferase 1 family. NDST subfamily.
genes like me logo Genes that share domains with NDST4: view

Function for NDST4 Gene

Molecular function for NDST4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-N-sulfoglucosamine
UniProtKB/Swiss-Prot Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity).

Enzyme Numbers (IUBMB) for NDST4 Gene

Gene Ontology (GO) - Molecular Function for NDST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity --
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity IEA --
GO:0016787 hydrolase activity --
GO:0019213 deacetylase activity IEA --
genes like me logo Genes that share ontologies with NDST4: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDST4

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NDST4 Gene

Localization for NDST4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDST4 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDST4 Gene COMPARTMENTS Subcellular localization image for NDST4 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NDST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDST4: view

Pathways for NDST4 Gene

genes like me logo Genes that share pathways with NDST4: view

UniProtKB/Swiss-Prot Q9H3R1-NDST4_HUMAN

  • Pathway: Glycan metabolism; heparan sulfate biosynthesis
  • Pathway: Glycan metabolism; heparin biosynthesis

Interacting Proteins for NDST4 Gene

Gene Ontology (GO) - Biological Process for NDST4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015012 heparan sulfate proteoglycan biosynthetic process IEA --
GO:0030210 heparin biosynthetic process IEA --
genes like me logo Genes that share ontologies with NDST4: view

Transcripts for NDST4 Gene

Unigene Clusters for NDST4 Gene

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDST4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NDST4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDST4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2: -

Relevant External Links for NDST4 Gene

GeneLoc Exon Structure for
NDST4
ECgene alternative splicing isoforms for
NDST4

Expression for NDST4 Gene

mRNA expression in normal human tissues for NDST4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDST4 Gene

This gene is overexpressed in Brain - Hypothalamus (6.4), Brain - Substantia nigra (4.7), and Prostate (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NDST4 Gene

SOURCE GeneReport for Unigene cluster for NDST4 Gene Hs.591700

genes like me logo Genes that share expressions with NDST4: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NDST4 Gene

Orthologs for NDST4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDST4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDST4 35
  • 99.46 (n)
  • 99.31 (a)
NDST4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDST4 35
  • 93.39 (n)
  • 97.94 (a)
NDST4 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDST4 35
  • 93.16 (n)
  • 97.48 (a)
NDST4 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndst4 35
  • 88.57 (n)
  • 95.87 (a)
Ndst4 16
Ndst4 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDST4 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDST4 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndst4 35
  • 87.88 (n)
  • 95.87 (a)
chicken
(Gallus gallus)
Aves NDST4 35
  • 81.27 (n)
  • 89.22 (a)
NDST4 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDST4 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndst4 35
  • 76.49 (n)
  • 84.52 (a)
zebrafish
(Danio rerio)
Actinopterygii ndst3 35
  • 68.92 (n)
  • 76.46 (a)
ndst3 36
  • 76 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sfl 36
  • 46 (a)
OneToMany
sfl 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea hst-1 36
  • 42 (a)
OneToMany
hst-1 37
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for NDST4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDST4 Gene

ENSEMBL:
Gene Tree for NDST4 (if available)
TreeFam:
Gene Tree for NDST4 (if available)

Paralogs for NDST4 Gene

Selected SIMAP similar genes for NDST4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NDST4: view

Variants for NDST4 Gene

Sequence variations from dbSNP and Humsavar for NDST4 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs169416 -- 114,972,945(-) CAGCT(C/T)TTTTG intron-variant
rs175926 -- 114,996,395(-) GTCTG(A/G)GTAAT intron-variant
rs188089 -- 114,986,616(-) AGTGC(A/G)GGACG intron-variant
rs193368 -- 114,969,268(-) ggcgg(A/G)atctc intron-variant
rs279505 -- 114,990,857(-) GGTGC(A/G)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDST4 Gene

Variant ID Type Subtype PubMed ID
dgv5677n71 CNV Gain 21882294
nsv879739 CNV Loss 21882294
nsv830040 CNV Gain 17160897
esv2570638 CNV Deletion 19546169
esv1983936 CNV Deletion 18987734
esv2728176 CNV Deletion 23290073
nsv292358 CNV Loss 16902084
dgv5678n71 CNV Loss 21882294
nsv461623 CNV Gain 19166990
nsv4480 CNV Loss 18451855
esv2659955 CNV Deletion 23128226
esv267807 CNV Insertion 20981092
nsv435800 CNV Deletion 17901297
esv1002972 CNV Gain 20482838
nsv822693 CNV Loss 20364138
nsv820612 CNV Deletion 20802225
nsv822694 CNV Loss 20364138
esv2728177 CNV Deletion 23290073
esv25921 CNV Gain+Loss 19812545
nsv511239 CNV Loss 21212237
esv2728178 CNV Deletion 23290073
esv2728179 CNV Deletion 23290073
dgv5679n71 CNV Loss 21882294
nsv830041 CNV Gain 17160897
nsv879743 CNV Loss 21882294
nsv879745 CNV Loss 21882294
nsv879747 CNV Loss 21882294
nsv879748 CNV Loss 21882294
esv2728180 CNV Deletion 23290073
esv2728181 CNV Deletion 23290073
esv2266453 CNV Deletion 18987734
esv5057 CNV Deletion 18987735
esv2728182 CNV Deletion 23290073
nsv290603 CNV Loss 16902084
esv2728183 CNV Deletion 23290073
esv1499242 CNV Deletion 17803354

Relevant External Links for NDST4 Gene

HapMap Linkage Disequilibrium report
NDST4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDST4 Gene

Disorders for NDST4 Gene

Relevant External Links for NDST4

Genetic Association Database (GAD)
NDST4
Human Genome Epidemiology (HuGE) Navigator
NDST4
genes like me logo Genes that share disorders with NDST4: view

No data available for UniProtKB/Swiss-Prot for NDST4 Gene

Publications for NDST4 Gene

  1. Multiple isozymes of heparan sulfate/heparin GlcNAc N- deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. (PMID: 11087757) Aikawa J. … Esko J.D. (J. Biol. Chem. 2001) 2 3 4 23
  2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3 48
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PMID: 22843503) Qi Q. … Qi L. (Hum. Mol. Genet. 2012) 3
  5. NDST4 is a novel candidate tumor suppressor gene at chromosome 4q26 and its genetic loss predicts adverse prognosis in colorectal cancer. (PMID: 23825612) Tzeng S.T. … Yang Y.C. (PLoS ONE 2013) 3

Products for NDST4 Gene

Sources for NDST4 Gene

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