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NDST3 Gene

protein-coding   GIFtS: 59
GCID: GC04P118954

N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl)...

  See NDST3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 31 2     N-Heparan Sulfate Sulfotransferase 32 3
Glucosaminyl N-Deacetylase/N-Sulfotransferase 32 3     N-HSST 32 3
HSST32 3     Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 32
NDST-32 3     GlcNAc N-Deacetylase/ N-Sulfotransferase 32
hNDST-32 3     EC 2.8.2.83

External Ids:    HGNC: 76821   Entrez Gene: 93482   Ensembl: ENSG000001641007   OMIM: 6039505   UniProtKB: O958033   

Export aliases for NDST3 gene to outside databases

Previous GC identifers: GC04P119708 GC04P119236 GC04P119348 GC04P119414 GC04P119313 GC04P114690


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDST3 Gene:
This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The
encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric
bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan
sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional
oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin.
(provided by RefSeq, Nov 2008)

GeneCards Summary for NDST3 Gene:
NDST3 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3) is a protein-coding gene. Diseases associated with NDST3 include mast cell neoplasm. GO annotations related to this gene include [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: NDST3_HUMAN, O95803
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
(GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
Has high deacetylase activity but low sulfotransferase activity

Gene Wiki entry for NDST3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDST3 gene promoter:
         LHX3b/Lhx3b   AP-1   AML1a   GCNF   Pax-2   Pax-2a   GCNF-1   LHX3a/Lhx3a   FOXJ2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDST3 promoter sequence
   Search Chromatin IP Primers for NDST3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDST3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q26   Ensembl cytogenetic band:  4q26   HGNC cytogenetic band: 4q26

NDST3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDST3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P118954:  view genomic region     (about GC identifiers)

Start:
118,954,773 bp from pter      End:
119,179,803 bp from pter
Size:
225,031 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDST3_HUMAN, O95803 (See protein sequence)
Recommended Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3  
Size: 873 amino acids; 100902 Da
Subunit: Monomer (By similarity)
Miscellaneous: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as
well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation
reactions, whereas other later on fill in or extend already modified heparan sulfate sequences
Secondary accessions: Q4W5C1 Q4W5D0 Q6UWC5 Q9UP21
Alternative splicing: 2 isoforms:  O95803-1   O95803-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDST3: NX_O95803

Explore proteomics data for NDST3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn146, Asn226, Asn342, Asn392, Asn658, Asn794
  • Modification sites at PhosphoSitePlus

  • See NDST3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004775.1  
    ENSEMBL proteins: 
     ENSP00000296499   ENSP00000396625  
    Reactome Protein details: O95803

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase
     IPR021930 Heparan_SO4_deacetylase

    Graphical View of Domain Structure for InterPro Entry O95803

    ProtoNet protein and cluster: O95803

    UniProtKB/Swiss-Prot: NDST3_HUMAN, O95803
    Similarity: Belongs to the sulfotransferase 1 family. NDST subfamily


    Find genes that share domains with NDST3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDST3_HUMAN, O95803
    Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
    (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
    backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
    Has high deacetylase activity but low sulfotransferase activity
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-N-sulfoglucosamine

         Enzyme Number (IUBMB): EC 2.8.2.81

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0019213deacetylase activity IEA--
         
    Find genes that share ontologies with NDST3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for NDST3:
     Decreased Wnt reporter activit  Elongated cells with protrusio  Synthetic lethal with Ras 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ndst3):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  embryogenesis 
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging  nervous system 
     skeleton  vision/eye 

    Find genes that share phenotypes with NDST3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ndst3tm1.1Grob for NDST3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDST3
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    miRNA
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    miRTarBase miRNAs that target NDST3:
    hsa-mir-335-5p (MIRT017221)

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    Selected qRT-PCR Assays for microRNAs that regulate NDST3 (see all 59):
    hsa-miR-579 hsa-miR-361-5p hsa-miR-3194-5p hsa-let-7d hsa-miR-1197 hsa-miR-199a-3p hsa-let-7g hsa-miR-629*
    SwitchGear 3'UTR luciferase reporter plasmidNDST3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NDST3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDST3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDST3_HUMAN, O95803: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with NDST3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDST3 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.00
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    4Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG biosynthesis0.57
    5Biological oxidations
    metapathway biotransformation0.42


    Find genes that share SuperPaths with NDST3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NDST3
        heparan sulfate biosynthesis (late stages)
    metapathway biotransformation
    heparan sulfate biosynthesis


    1 Reactome Pathway for NDST3
        HS-GAG biosynthesis


    2 Kegg Pathways  (Kegg details for NDST3):
        Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    Metabolic pathways

    UniProtKB/Swiss-Prot: NDST3_HUMAN, O95803
    Pathway: Glycan metabolism; heparan sulfate biosynthesis
    Pathway: Glycan metabolism; heparin biosynthesis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDST3
    Interactions:

        Search GeneGlobe Interaction Network for NDST3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for NDST3 (ENSP000002964994) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HS3ST1ENSP000000025964STRING: ENSP00000002596
    HS3ST2ENSP000002613744STRING: ENSP00000261374
    HS3ST3A1ENSP000002841104STRING: ENSP00000284110
    HS6ST1ENSP000002592414STRING: ENSP00000259241
    HS6ST3ENSP000003658954STRING: ENSP00000365895
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015012heparan sulfate proteoglycan biosynthetic process IEA--
    GO:0030210heparin biosynthetic process IEA--

    Find genes that share ontologies with NDST3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDST3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDST3 gene: 
    NM_004784.2  

    Unigene Cluster for NDST3:

    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
    Hs.480596  [show with all ESTs]
    Unigene Representative Sequence: NM_004784
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394488(uc003ibw.3) ENST00000296499(uc011cgf.1 uc003ibx.3)
    ENST00000433996
    miRNA
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    hsa-miR-579 hsa-miR-361-5p hsa-miR-3194-5p hsa-let-7d hsa-miR-1197 hsa-miR-199a-3p hsa-let-7g hsa-miR-629*
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF074924.1 AF076605.1 AK295439.1 AY358852.1 BC034037.1 BC109309.1 BC109310.1 HQ234312.1 

    2 DOTS entries:

    DT.209371  DT.101959150 

    1 AceView cDNA sequence:

    AA354508 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDST3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACCTCATA
    NDST3 Expression
    About this image


    NDST3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)
             Mesencephalic Basal Plate
    NDST3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDST3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.480596

    UniProtKB/Swiss-Prot: NDST3_HUMAN, O95803
    Tissue specificity: Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal
    spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDST3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndst31 , 5 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more1, 5 88.93(n)1
    93.47(a)1
      3 (54.58 cM)5
    833981  NM_031186.21  NP_112463.21 
     1235261665 
    chicken
    (Gallus gallus)
    Aves NDST31 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 81.94(n)
    90.38(a)
      428769  XM_004941244.1  XP_004941301.1 
    lizard
    (Anolis carolinensis)
    Reptilia NDST36
    N-deacetylase/N-sulfotransferase (heparan glucosam...
    83(a)
    1 ↔ 1
    5(140546566-140599882)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ndst31 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 75.22(n)
    79.84(a)
      100145653  NM_001127047.1  NP_001120519.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndst36
    N-deacetylase/N-sulfotransferase (heparan glucosam...
    75(a)
    1 → many
    1(18885370-19054531) ENSDARG00000041776
    fruit fly
    (Drosophila melanogaster)
    Insecta sfl3 cell surface receptor linked signal
    transduction more
    58(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea hst-13 N-heparan sulfate sulfotransferase 44(a)   IV(8688631-8691631)   --


    ENSEMBL Gene Tree for NDST3 (if available)
    TreeFam Gene Tree for NDST3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDST3 gene
    HS3ST22  NDST22  ENSG000002729162  HS3ST12  HS3ST3B12  HS3ST42  HS3ST62  HS3ST52  
    HS3ST3A12  NDST12  NDST42  
    4 SIMAP similar genes for NDST3 using alignment to 2 protein entries:     NDST3_HUMAN (see all proteins):
    NDST4    NDST2    NDST1    HS3ST1

    Find genes that share paralogs with NDST3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDST3 (see all 4186)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361314
    A colorectal cancer sample4--see VAR_0361312 H Q mis40--------
    rs1846263591,2
    --118953726(+) TAGAAC/TTTATT 1 -- us2k10--------
    rs65340771,2
    C,A,H--118953737(+) TCAGCC/TACAGC 1 -- us2k112Minor allele frequency- T:0.34NA WA CSA EA 377
    rs1892890111,2
    --118953746(+) GCTCGA/TTTCCA 1 -- us2k10--------
    rs1819585751,2
    --118953778(+) GTTTCA/TCTTTT 1 -- us2k10--------
    rs1421347241,2
    --118953790(+) TCCAAC/TTCTCA 1 -- us2k10--------
    rs1137868111,2
    C--118953808(+) CTTCC-/TGAG  
            
    TATCA
    1 -- us2k11Minor allele frequency- TGAG:0.00CSA 2
    rs359436391,2
    C--118953809(+) TTCCT-/GAGT  
            
    ATCAG
    1 -- us2k10--------
    rs1844457821,2
    --118953829(+) TTTCAC/GACTTC 1 -- us2k10--------
    rs65340781,2
    C,F,A,H--118953901(+) AGAGGG/AAGGAA 1 -- us2k1 trp323Minor allele frequency- A:0.34NS EA NA WA CSA 2347

    HapMap Linkage Disequilibrium report for NDST3 (118954773 - 119179803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NDST3 (see all 22):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2728215CNV Deletion23290073
    esv1403828CNV Deletion17803354
    esv1771263CNV Deletion17803354
    dgv970e199CNV Deletion23128226
    esv2728216CNV Deletion23290073
    esv1712451CNV Insertion17803354
    nsv4485CNV Loss18451855
    nsv879839CNV Loss21882294
    nsv514247CNV Loss21397061
    esv21468CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDST3
    DNA2.0 Custom Variant and Variant Library Synthesis for NDST3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 603950    OMIM disorders: --

    1 disease for NDST3:    
    About MalaCards
    mast cell neoplasm

    1 disease from the University of Copenhagen DISEASES database for NDST3:
    Mast cell neoplasm

    Find genes that share disorders with NDST3           About GenesLikeMe

    Genetic Association Database (GAD): NDST3
    Human Genome Epidemiology (HuGE) Navigator: NDST3 (3 documents)

    Export disorders for NDST3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDST3 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with NDST3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. (PubMed id 9915799)1, 2, 3 Aikawa J. and Esko J.D. (J. Biol. Chem. 1999)
    2. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide searching of rare genetic variants in WTCCC data. (PubMed id 20549515)1, 4 Feng T. and Zhu X. (Hum. Genet. 2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Multiple isozymes of heparan sulfate/heparin GlcNAc N- deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. (PubMed id 11087757)1, 9 Aikawa J.... Esko J.D. (J. Biol. Chem. 2001)
    9. Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. (PubMed id 21948523)1 Al-Balool H.H....Jackson M.S. (Genome Res. 2011)
    10. Glycanogenomics: a qPCR-approach to investigate biological glycan function. (PubMed id 18692483)1 Krenn E.C....Kungl A.J. (Biochem. Biophys. Res. Commun. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9348 HGNC: 7682 AceView: NDST3.2 Ensembl:ENSG00000164100 euGenes: HUgn9348
    ECgene: NDST3 Kegg: 9348 H-InvDB: NDST3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NDST3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NDST3 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=NDST3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NDST3 gene:
    Search GeneIP for patents involving NDST3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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