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Aliases for NDST3 Gene

Aliases for NDST3 Gene

  • N-Deacetylase/N-Sulfotransferase 3 2 3
  • N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 3 2 3 5
  • Glucosaminyl N-Deacetylase/N-Sulfotransferase 3 3 4
  • N-Heparan Sulfate Sulfotransferase 3 3 4
  • N-HSST 3 3 4
  • HNDST-3 3 4
  • NDST-3 3 4
  • HSST3 3 4
  • GlcNAc N-Deacetylase/ N-Sulfotransferase 3 3
  • EC 2.8.2.8 4

External Ids for NDST3 Gene

Previous GeneCards Identifiers for NDST3 Gene

  • GC04P119708
  • GC04P119236
  • GC04P119348
  • GC04P119414
  • GC04P119313
  • GC04P118954
  • GC04P114690

Summaries for NDST3 Gene

Entrez Gene Summary for NDST3 Gene

  • This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]

GeneCards Summary for NDST3 Gene

NDST3 (N-Deacetylase/N-Sulfotransferase 3) is a Protein Coding gene. Among its related pathways are heparan sulfate biosynthesis and Glycosaminoglycan metabolism. GO annotations related to this gene include hydrolase activity and deacetylase activity. An important paralog of this gene is NDST4.

UniProtKB/Swiss-Prot for NDST3 Gene

  • Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.

Gene Wiki entry for NDST3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDST3 Gene

Genomics for NDST3 Gene

Regulatory Elements for NDST3 Gene

Enhancers for NDST3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NDST3 on UCSC Golden Path with GeneCards custom track

Promoters for NDST3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDST3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDST3 Gene

Chromosome:
4
Start:
118,033,618 bp from pter
End:
118,258,648 bp from pter
Size:
225,031 bases
Orientation:
Plus strand

Genomic View for NDST3 Gene

Genes around NDST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDST3 Gene

Proteins for NDST3 Gene

  • Protein details for NDST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95803-NDST3_HUMAN
    Recommended name:
    Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3
    Protein Accession:
    O95803
    Secondary Accessions:
    • B4DI67
    • Q4W5C1
    • Q4W5D0
    • Q6UWC5
    • Q9UP21

    Protein attributes for NDST3 Gene

    Size:
    873 amino acids
    Molecular mass:
    100902 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.

    Alternative splice isoforms for NDST3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDST3 Gene

Proteomics data for NDST3 Gene at MOPED

Post-translational modifications for NDST3 Gene

  • Glycosylation at Asn 146, Asn 226, Asn 342, Asn 392, Asn 658, and Asn 794
  • Modification sites at PhosphoSitePlus

Other Protein References for NDST3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NDST3 Gene

Domains & Families for NDST3 Gene

Gene Families for NDST3 Gene

Protein Domains for NDST3 Gene

Graphical View of Domain Structure for InterPro Entry

O95803

UniProtKB/Swiss-Prot:

NDST3_HUMAN :
  • Belongs to the sulfotransferase 1 family. NDST subfamily.
Family:
  • Belongs to the sulfotransferase 1 family. NDST subfamily.
genes like me logo Genes that share domains with NDST3: view

Function for NDST3 Gene

Molecular function for NDST3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.
UniProtKB/Swiss-Prot Function:
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity.

Enzyme Numbers (IUBMB) for NDST3 Gene

Gene Ontology (GO) - Molecular Function for NDST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008146 sulfotransferase activity IEA --
genes like me logo Genes that share ontologies with NDST3: view
genes like me logo Genes that share phenotypes with NDST3: view

Animal Models for NDST3 Gene

MGI Knock Outs for NDST3:

Animal Model Products

  • Taconic Biosciences Mouse Models for NDST3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDST3 Gene

Localization for NDST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDST3 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDST3 Gene COMPARTMENTS Subcellular localization image for NDST3 gene
Compartment Confidence
golgi apparatus 4
endoplasmic reticulum 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for NDST3 Gene

Pathways & Interactions for NDST3 Gene

genes like me logo Genes that share pathways with NDST3: view

UniProtKB/Swiss-Prot O95803-NDST3_HUMAN

  • Pathway: Glycan metabolism; heparan sulfate biosynthesis.
  • Pathway: Glycan metabolism; heparin biosynthesis.

Interacting Proteins for NDST3 Gene

Gene Ontology (GO) - Biological Process for NDST3 Gene

None

No data available for SIGNOR curated interactions for NDST3 Gene

Drugs & Compounds for NDST3 Gene

(2) Additional Compounds for NDST3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with NDST3: view

Transcripts for NDST3 Gene

mRNA/cDNA for NDST3 Gene

(5) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NDST3 Gene

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDST3 Gene

No ASD Table

Relevant External Links for NDST3 Gene

GeneLoc Exon Structure for
NDST3
ECgene alternative splicing isoforms for
NDST3

Expression for NDST3 Gene

mRNA expression in normal human tissues for NDST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDST3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.8), Brain - Nucleus accumbens (basal ganglia) (x5.9), Brain - Cerebellum (x5.9), Brain - Frontal Cortex (BA9) (x4.8), Brain - Anterior cingulate cortex (BA24) (x4.6), Brain - Putamen (basal ganglia) (x4.5), Brain - Caudate (basal ganglia) (x4.5), and Brain - Cortex (x4.4).

SOURCE GeneReport for Unigene cluster for NDST3 Gene Hs.480596

mRNA Expression by UniProt/SwissProt for NDST3 Gene

O95803-NDST3_HUMAN
Tissue specificity: Expressed in brain, kidney, liver, fetal and adult lung, adult pancreas, placenta, fetal spleen and fetal thymus. Not detected in adult/ fetal heart and skeletal muscle.
genes like me logo Genes that share expression patterns with NDST3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NDST3 Gene

Orthologs for NDST3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDST3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NDST3 35
  • 93.17 (n)
  • 96.68 (a)
NDST3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndst3 35
  • 88.93 (n)
  • 93.47 (a)
Ndst3 16
Ndst3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDST3 35
  • 99.92 (n)
  • 99.89 (a)
NDST3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndst3 35
  • 88.66 (n)
  • 93.01 (a)
cow
(Bos Taurus)
Mammalia NDST3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDST3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves NDST3 35
  • 81.94 (n)
  • 90.38 (a)
NDST3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDST3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndst3 35
  • 75.22 (n)
  • 79.84 (a)
zebrafish
(Danio rerio)
Actinopterygii ndst3 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sfl 37
  • 58 (a)
sfl 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hst-1 37
  • 44 (a)
hst-1 36
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for NDST3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDST3 Gene

ENSEMBL:
Gene Tree for NDST3 (if available)
TreeFam:
Gene Tree for NDST3 (if available)

Paralogs for NDST3 Gene

(4) SIMAP similar genes for NDST3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NDST3: view

Variants for NDST3 Gene

Sequence variations from dbSNP and Humsavar for NDST3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_036131 A colorectal cancer sample
rs788662 -- 118,235,378(+) CCAGC(A/C)ACTAC intron-variant
rs788663 -- 118,234,074(+) TGATA(C/T)TGATT intron-variant
rs788664 -- 118,227,239(+) TTTTT(C/T)CCCCC intron-variant
rs581739 -- 118,249,600(+) TTTAC(A/G)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDST3 Gene

Variant ID Type Subtype PubMed ID
dgv1668e1 CNV Complex 17122850
esv34354 CNV Gain 17911159
nsv519017 CNV Loss 19592680
nsv879839 CNV Loss 21882294
esv1403828 CNV Deletion 17803354
esv1712451 CNV Insertion 17803354
esv1771263 CNV Deletion 17803354
esv2728215 CNV Deletion 23290073
esv34038 CNV Loss 18971310
nsv4485 CNV Loss 18451855
nsv511250 CNV Loss 21212237
nsv10556 CNV Loss 18304495
nsv820226 CNV Loss 19587683
dgv970e199 CNV Deletion 23128226
nsv513162 CNV Loss 21212237
esv2728216 CNV Deletion 23290073
nsv499064 CNV Loss 21111241
nsv291334 CNV Loss 16902084
esv21468 CNV Loss 19812545
dgv893n67 CNV Loss 20364138
nsv514247 CNV Loss 21397061
nsv10557 CNV Loss 18304495

Variation tolerance for NDST3 Gene

Residual Variation Intolerance Score: 8.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NDST3 Gene

Disorders for NDST3 Gene

Relevant External Links for NDST3

Genetic Association Database (GAD)
NDST3
Human Genome Epidemiology (HuGE) Navigator
NDST3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDST3

No disorders were found for NDST3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDST3 Gene

Publications for NDST3 Gene

  1. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. (PMID: 9915799) Aikawa J. … Esko J.D. (J. Biol. Chem. 1999) 2 3 4 67
  2. Multiple isozymes of heparan sulfate/heparin GlcNAc N- deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4. (PMID: 11087757) Aikawa J. … Esko J.D. (J. Biol. Chem. 2001) 3 23
  3. rs11098403 polymorphism near NDST3 is associated with a reduced risk of schizophrenia in a Han Chinese population. (PMID: 25139529) Gu L.Z. … Ling W.M. (Neurosci. Lett. 2014) 3
  4. Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder. (PMID: 24253340) Lencz T. … Darvasi A. (Nat Commun 2013) 3
  5. Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. (PMID: 21948523) Al-Balool H.H. … Jackson M.S. (Genome Res. 2011) 3

Products for NDST3 Gene

Sources for NDST3 Gene

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