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Aliases for NDST2 Gene

Aliases for NDST2 Gene

  • N-Deacetylase And N-Sulfotransferase 2 2 3 5
  • N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 2 2 3
  • Glucosaminyl N-Deacetylase/N-Sulfotransferase 2 3 4
  • N-Heparan Sulfate Sulfotransferase 2 3 4
  • N-HSST 2 3 4
  • NDST-2 3 4
  • HSST2 3 4
  • Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 2 3
  • N-Deacetylase/N-Sulfotransferase 2 3
  • EC 2.8.2.8 4
  • NST2 3

External Ids for NDST2 Gene

Previous GeneCards Identifiers for NDST2 Gene

  • GC10M074340
  • GC10M074665
  • GC10M075454
  • GC10M074906
  • GC10M075231
  • GC10M075561
  • GC10M069557

Summaries for NDST2 Gene

Entrez Gene Summary for NDST2 Gene

  • This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]

GeneCards Summary for NDST2 Gene

NDST2 (N-Deacetylase And N-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. GO annotations related to this gene include hydrolase activity and [heparan sulfate]-glucosamine N-sulfotransferase activity. An important paralog of this gene is ENSG00000272916.

UniProtKB/Swiss-Prot for NDST2 Gene

  • Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Gene Wiki entry for NDST2 Gene

Additional gene information for NDST2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDST2 Gene

Genomics for NDST2 Gene

Regulatory Elements for NDST2 Gene

Enhancers for NDST2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H073991 1.5 Ensembl ENCODE dbSUPER 33.8 -180.8 -180775 2 HDGF PKNOX1 ATF1 TCF12 ZNF766 GATA2 FOS ATF7 RUNX3 CAVIN1 NDST2 AP3M1 ENSG00000272140 BMS1P4 ZSWIM8 ZSWIM8-AS1 SEC24C ECD VCL GLUD1P3
GH10H073780 1.3 ENCODE dbSUPER 36.8 +29.9 29872 2 PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 ZNF143 SP3 NDST2 ZSWIM8 SEC24C ECD AP3M1 GLUD1P3 DUSP8P5 MYOZ1 ENSG00000272140 BMS1P4
GH10H073624 1.4 ENCODE dbSUPER 33.4 +186.0 185954 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF207 NDST2 SEC24C ZSWIM8 NUDT13 AP3M1 ENSG00000272140 GLUD1P3 ECD DUSP8P5 CFAP70
GH10H073886 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23 -79.2 -79179 10 HDGF PKNOX1 FOXA2 SIN3A ZNF2 ZNF121 GLIS2 GATA2 ZNF143 ZNF207 NDST2 ENSG00000272791 ENSG00000268584 AGAP5 ENSG00000227540 C10orf55 FUT11 ENSG00000229990 ENSG00000272599 ENSG00000224195
GH10H073809 1.3 ENCODE dbSUPER 30.7 +0.8 814 3 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 SP3 SP5 ECD ZSWIM8 DUSP8P5 NDST2 SEC24C FUT11 ENSG00000272140 GLUD1P3 ENSG00000242288 CAMK2G
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NDST2 on UCSC Golden Path with GeneCards custom track

Promoters for NDST2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029862 431 1601 ARNT ARID4B SIN3A DMAP1 ZNF143 ZNF207 SP3 SP5 MXD4 REST

Genomic Location for NDST2 Gene

Chromosome:
10
Start:
73,801,911 bp from pter
End:
73,811,831 bp from pter
Size:
9,921 bases
Orientation:
Minus strand

Genomic View for NDST2 Gene

Genes around NDST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDST2 Gene

Proteins for NDST2 Gene

  • Protein details for NDST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52849-NDST2_HUMAN
    Recommended name:
    Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
    Protein Accession:
    P52849
    Secondary Accessions:
    • Q2TB32
    • Q59H89

    Protein attributes for NDST2 Gene

    Size:
    883 amino acids
    Molecular mass:
    100875 Da
    Quaternary structure:
    • Monomer.
    Miscellaneous:
    • The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions, whereas other later on fill in or extend already modified heparan sulfate sequences.

    Alternative splice isoforms for NDST2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDST2 Gene

Post-translational modifications for NDST2 Gene

  • Glycosylation at Asn233, Asn350, Asn400, Asn666, posLast=726726, and posLast=802802
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NDST2 Gene

Domains & Families for NDST2 Gene

Gene Families for NDST2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NDST2 Gene

Graphical View of Domain Structure for InterPro Entry

P52849

UniProtKB/Swiss-Prot:

NDST2_HUMAN :
  • Belongs to the sulfotransferase 1 family. NDST subfamily.
Family:
  • Belongs to the sulfotransferase 1 family. NDST subfamily.
genes like me logo Genes that share domains with NDST2: view

Function for NDST2 Gene

Molecular function for NDST2 Gene

GENATLAS Biochemistry:
heparan sulfate-N-deacetylase/N-sulfotransferase 2,with two alternative forms,predominantly expressed in heart,liver,pancreas,located to the trans-Golgi network
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=4.7 uM for K5 polysaccharide {ECO:0000269 PubMed:12634318}; KM=0.76 uM for N-acetylated HS-II {ECO:0000269 PubMed:12634318};
UniProtKB/Swiss-Prot CatalyticActivity:
3-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3,5-bisphosphate + [heparan sulfate]-N-sulfoglucosamine.
UniProtKB/Swiss-Prot Function:
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

Enzyme Numbers (IUBMB) for NDST2 Gene

Phenotypes From GWAS Catalog for NDST2 Gene

Gene Ontology (GO) - Molecular Function for NDST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0008146 sulfotransferase activity IEA --
GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity TAS,IEA --
GO:0016740 transferase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NDST2: view
genes like me logo Genes that share phenotypes with NDST2: view

Animal Models for NDST2 Gene

MGI Knock Outs for NDST2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NDST2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NDST2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NDST2 Gene

Localization for NDST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDST2 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDST2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
cytosol 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NDST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NDST2: view

Pathways & Interactions for NDST2 Gene

genes like me logo Genes that share pathways with NDST2: view

UniProtKB/Swiss-Prot P52849-NDST2_HUMAN

  • Pathway: Glycan metabolism; heparan sulfate biosynthesis.
  • Pathway: Glycan metabolism; heparin biosynthesis.

Gene Ontology (GO) - Biological Process for NDST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0008152 metabolic process IEA --
GO:0015012 heparan sulfate proteoglycan biosynthetic process IEA --
GO:0030210 heparin biosynthetic process IEA --
genes like me logo Genes that share ontologies with NDST2: view

No data available for SIGNOR curated interactions for NDST2 Gene

Drugs & Compounds for NDST2 Gene

(2) Additional Compounds for NDST2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine 3',5'-diphosphate
  • 3'-Phosphoryl-AMP
  • 3,5-ADP
  • 3,5-Diphosphoadenosine
  • 3-Phosphoadenosine 5-phosphate
  • 5-(Dihydrogen phosphate) 3-Adenylate
1053-73-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with NDST2: view

Transcripts for NDST2 Gene

Unigene Clusters for NDST2 Gene

N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NDST2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NDST2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b
SP1: - - -
SP2: -
SP3: - -
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for NDST2 Gene

GeneLoc Exon Structure for
NDST2
ECgene alternative splicing isoforms for
NDST2

Expression for NDST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDST2 Gene

mRNA differential expression in normal tissues according to GTEx for NDST2 Gene

This gene is overexpressed in Whole Blood (x4.2).

Protein differential expression in normal tissues from HIPED for NDST2 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (49.2), Adipocyte (10.8), and Spleen (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDST2 Gene



Protein tissue co-expression partners for NDST2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NDST2 Gene:

NDST2

SOURCE GeneReport for Unigene cluster for NDST2 Gene:

Hs.654758

Evidence on tissue expression from TISSUES for NDST2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with NDST2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDST2 Gene

Orthologs for NDST2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDST2 33 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
OneToMany
NDST2 33
  • 94.64 (n)
cow
(Bos Taurus)
Mammalia NDST2 33 34
  • 93.39 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 93 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ndst2 33 16 34
  • 91.51 (n)
rat
(Rattus norvegicus)
Mammalia Ndst2 33
  • 90.18 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 82 (a)
OneToMany
NDST2 33
  • 74.15 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 81 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ndst2 33
  • 71.08 (n)
zebrafish
(Danio rerio)
Actinopterygii ndst2a 33 34 34
  • 70.77 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006328 33
  • 59.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta sfl 35 33 34
  • 56.65 (n)
worm
(Caenorhabditis elegans)
Secernentea hst-1 35 33 34
  • 49.28 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
OneToMany
Species where no ortholog for NDST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDST2 Gene

ENSEMBL:
Gene Tree for NDST2 (if available)
TreeFam:
Gene Tree for NDST2 (if available)

Paralogs for NDST2 Gene

(6) SIMAP similar genes for NDST2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NDST2: view

Variants for NDST2 Gene

Sequence variations from dbSNP and Humsavar for NDST2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs141599100 Likely benign 73,808,190(+) AGGCC(A/C/G)TGCAG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs368488804 Likely benign 73,808,364(+) TGGGC(A/G/T)TACCA nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000058719 -- 73,807,520(+) TAAGT(C/T)TGTGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000396056 -- 73,811,563(+) GCCGC(A/G)TCGCG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000428573 -- 73,811,762(+) CGAGA(C/T)GGCGG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NDST2 Gene

Variant ID Type Subtype PubMed ID
dgv46n21 CNV loss 19592680
nsv1035634 CNV gain 25217958
nsv551516 CNV loss 21841781
nsv551517 CNV loss 21841781
nsv825468 CNV gain 20364138
nsv831912 CNV gain 17160897

Variation tolerance for NDST2 Gene

Residual Variation Intolerance Score: 17.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDST2 Gene

Human Gene Mutation Database (HGMD)
NDST2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDST2 Gene

Disorders for NDST2 Gene

Relevant External Links for NDST2

Genetic Association Database (GAD)
NDST2
Human Genome Epidemiology (HuGE) Navigator
NDST2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDST2

No disorders were found for NDST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NDST2 Gene

Publications for NDST2 Gene

  1. Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2. (PMID: 16343444) Duncan MB … Liu J (Biochemical and biophysical research communications 2006) 3 4 22 60
  2. cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2. (PMID: 9601056) Humphries DE … Karlinsky JB (The Biochemical journal 1998) 2 3 4 60
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Influence of high glucose concentrations on the expression of glycosaminoglycans and N-deacetylase/N-sulphotransferase mRNA in cultured skin fibroblasts from diabetic patients with or without nephropathy. (PMID: 11865082) Yard B … van Der Woude F (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002) 3 22 60

Products for NDST2 Gene

Sources for NDST2 Gene

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