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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDST2 Gene

protein-coding   GIFtS: 59
GCID: GC10M075561

N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl)...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 21 2     N-HSST 22 3
Glucosaminyl N-Deacetylase/N-Sulfotransferase 22 3     NST22
HSST22 3     Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 22
NDST-22 3     EC 2.8.2.83
N-Heparan Sulfate Sulfotransferase 22 3     

External Ids:    HGNC: 76811   Entrez Gene: 85092   Ensembl: ENSG000001665077   OMIM: 6032685   UniProtKB: P528493   

Export aliases for NDST2 gene to outside databases

Previous GC identifers: GC10M074340 GC10M074665 GC10M075454 GC10M074906 GC10M075231 GC10M069557


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NDST2 Gene:
This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins.
The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation
and N-sulfation. The encoded protein may be localized to the Golgi. (provided by RefSeq, Feb 2009)

GeneCards Summary for NDST2 Gene: 
NDST2 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2) is a protein-coding gene. Diseases associated with NDST2 include morquio syndrome b, and alzheimer's disease, and among its related super-pathways are Glycosaminoglycan biosynthesis - heparan sulfate / heparin and Metabolic pathways. GO annotations related to this gene include [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
(GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
Plays a role in determining the extent and pattern of sulfation of heparan sulfate

Gene Wiki entry for NDST2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDST2 gene promoter:
         GR   Nkx3-1 v4   Nkx2-5   AP-2gamma   Egr-4   AP-2beta   Nkx3-1 v3   GR-alpha   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDST2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDST2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22

NDST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDST2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M075561:  view genomic region     (about GC identifiers)

Start:
75,556,272 bp from pter      End:
75,571,589 bp from pter
Size:
15,318 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849 (See protein sequence)
Recommended Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2  
Size: 883 amino acids; 100875 Da
Subunit: Monomer (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Miscellaneous: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as
well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation
reactions, whereas other later on fill in or extend already modified heparan sulfate sequences
Secondary accessions: Q2TB32 Q59H89
Alternative splicing: 2 isoforms:  P52849-1   P52849-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDST2: NX_P52849

Explore proteomics data for NDST2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52849

  • NDST2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDST2 Protein Expression
    REFSEQ proteins: NP_003626.1  
    ENSEMBL proteins: 
     ENSP00000475031   ENSP00000310657   ENSP00000392733   ENSP00000299641  
    Reactome Protein details: P52849
    Human Recombinant Protein Products for NDST2: 
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral to membrane IEA--

    NDST2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase
     IPR021930 Heparan_SO4_deacetylase

    Graphical View of Domain Structure for InterPro Entry P52849

    ProtoNet protein and cluster: P52849

    UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849
    Similarity: Belongs to the sulfotransferase 1 family. NDST subfamily


    NDST2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDST2_HUMAN, P52849
    Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
    (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
    backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
    Plays a role in determining the extent and pattern of sulfation of heparan sulfate
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-N-sulfoglucosamine
    Biophysicochemical properties: Kinetic parameters: KM=4.7 uM for K5 polysaccharide; KM=0.76 uM for N-acetylated
    HS-II;

         Genatlas biochemistry entry for NDST2:
    heparan sulfate-N-deacetylase/N-sulfotransferase 2,with two alternative forms,predominantly expressed in
    heart,liver,pancreas,located to the trans-Golgi network

         Enzyme Number (IUBMB): EC 2.8.2.81

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activity IEA--
    GO:0016787hydrolase activity ----
    GO:0019213deacetylase activity IEA--
         
    NDST2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ndst2):
     embryogenesis  endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging 
     skeleton  vision/eye 

    NDST2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NDST2: Ndst2tm1Lex Ndst2tm1Lkj Ndst2tm1Rls

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NDST2 
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    SwitchGear 3'UTR luciferase reporter plasmidNDST2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDST2 About   (see all 6)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.77
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3MPS IIIC - Sanfilippo syndrome C
    MPS IIIC - Sanfilippo syndrome C0.48
    Mucopolysaccharidoses0.48
    MPS IV - Morquio syndrome A0.48
    MPS IIID - Sanfilippo syndrome D0.48
    MPS IV - Morquio syndrome B0.48
    MPS I - Hurler syndrome0.48
    MPS VI - Maroteaux-Lamy syndrome0.48
    MPS IX - Natowicz syndrome0.48
    4Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.56
    HS-GAG biosynthesis0.56
    5Biological oxidations
    metapathway biotransformation0.41

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NDST2
        heparan sulfate biosynthesis (late stages)
    metapathway biotransformation
    heparan sulfate biosynthesis

    5/18        Reactome Pathways for NDST2 (see all 18)
        MPS VI - Maroteaux-Lamy syndrome
    Metabolism
    Disease
    HS-GAG biosynthesis
    MPS II - Hunter syndrome


    2         Kegg Pathways  (Kegg details for NDST2):
        Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    Metabolic pathways

    UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849
    Pathway: Glycan metabolism; heparan sulfate biosynthesis
    Pathway: Glycan metabolism; heparin biosynthesis


    NDST2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDST2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/26 Interacting proteins for NDST2 (P528493 ENSP000002996414) via UniProtKB, MINT, STRING, and/or I2D (see all 26)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPC5P783333, ENSP000003662674I2D: score=1 STRING: ENSP00000366267
    CDC27P302603I2D: score=4 
    GRB2P629933I2D: score=2 
    FGFR3P226073I2D: score=1 
    EXT1ENSP000003674464STRING: ENSP00000367446
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002002regulation of angiotensin levels in blood IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0009987cellular process ----
    GO:0015012heparan sulfate proteoglycan biosynthetic process IEA--

    NDST2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDST2 gene: 
    NM_003635.3  

    Unigene Cluster for NDST2:

    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
    Hs.654758  [show with all ESTs]
    Unigene Representative Sequence: NM_003635
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000603027 ENST00000456638 ENST00000603706 ENST00000309979(uc010qks.1 uc001jvl.1 uc009xro.2 uc010qku.1)
    ENST00000429742 ENST00000463410 ENST00000465929 ENST00000398701 ENST00000299641(uc001jvk.2 uc010qkt.1)


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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate NDST2 (see all 15):
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    Additional mRNA sequence: 

    AK293527.1 AK298957.1 AK300520.1 AK301251.1 AK303648.1 BC035711.1 BC110588.1 BC110589.1 
    U36601.1 

    8 DOTS entries:

    DT.116794  DT.91864741  DT.92013689  DT.91688062  DT.91742477  DT.91714064  DT.121293091  DT.95119037 

    24/158 AceView cDNA sequences (see all 158):

    W24510 BF434496 NM_003635 CF529390 U36601 BU730523 AU125430 AL079419 
    AA903589 BG055780 AI088376 AA934803 CK902419 CA405478 AW074575 AL080182 
    BC035711 AA428738 CB144454 CR625829 T32268 AI354728 BX342466 AA477108 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NDST2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b
    SP1:                          -           -                                                                                               -               
    SP2:                                                                                                                    -                                 
    SP3:                                                                                                                    -                 -               
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for NDST2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDST2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGACCC
    NDST2 Expression
    About this image


    See NDST2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDST2

    SOURCE GeneReport for Unigene cluster: Hs.654758
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NDST2 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndst21 , 5 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more1, 5 91.51(n)1
    96.72(a)1
      14 (11.53 cM)5
    174231  NM_010811.21  NP_034941.21 
     207237395 
    chicken
    (Gallus gallus)
    Aves NDST21 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 74.95(n)
    83.28(a)
      423738  XM_421613.3  XP_421613.2 
    lizard
    (Anolis carolinensis)
    Reptilia NDST26
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343196.1(1421790-1502256)
    zebrafish
    (Danio rerio)
    Actinopterygii ndst2a1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 71.16(n)
    76.6(a)
      793524  XM_001924015.2  XP_001924050.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sfl1 , 3 cell surface receptor linked signal
    transduction more3
    sulfateless1
    54(a)3
    56.51(n)1
    55.66(a)1
      387361  NM_079222.31  NP_523946.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hst-11 , 3 N-heparan sulfate sulfotransferase3
    Protein HST-11
    43(a)3
    50.33(n)1
    46.29(a)1
      IV(8688631-8691631)3
    1776751  NM_069090.31  NP_501491.31 


    ENSEMBL Gene Tree for NDST2 (if available)
    TreeFam Gene Tree for NDST2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDST2 gene
    HS3ST22  HS3ST12  HS3ST3B12  HS3ST42  HS3ST62  HS3ST52  HS3ST3A12  NDST12  
    NDST42  NDST32  
    6 SIMAP similar genes for NDST2 using alignment to 3 protein entries:     NDST2_HUMAN (see all proteins):
    NDST4    NDST1    NDST3    HS3ST3A1    HS3ST1    HS3ST4

    NDST2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/225 SNPs in NDST2 are shown (see all 225)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426654651,2
    C--75563205(+) CAGCAC/TGGGTA 1 -- int10--------
    rs110007811,2
    C,H--75563243(+) CTCAAA/GCCTCA 1 -- int14Minor allele frequency- G:0.00NS EA 406
    rs1830583591,2
    --75563261(+) CTCCCA/TCTCTA 1 -- int10--------
    rs2006513711,2
    C--75563287(+) TCCCCC/GCTCCC 1 -- int10--------
    rs1873970921,2
    C--75563375(+) GCACTA/GTGATG 2 T I mis10--------
    rs1419485581,2
    C,F--75563467(+) AAATCA/TGTGCT 2 T syn12Minor allele frequency- T:0.00NA EU 5865
    rs2001328911,2
    --75563487(+) AGGAAA/CAGGGA 2 V F mis10--------
    rs1833349651,2
    --75563573(+) CTGTGC/TTGAGG 1 -- int10--------
    rs746662011,2
    C,F--75563600(+) ATTTTG/CGGGGA 1 -- int11Minor allele frequency- C:0.02EU 731
    rs755381231,2
    C--75563667(+) CTTGTG/CGTAAT 2 /H /D mis12Minor allele frequency- C:0.00NA EU 5465

    HapMap Linkage Disequilibrium report for NDST2 (75556272 - 75571589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NDST2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv46n21CNV Loss19592680
    nsv825468CNV Gain20364138
    nsv831912CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603268    OMIM disorders: --

    3 diseases for NDST2:    About MalaCards
    morquio syndrome b    alzheimer's disease    endotheliitis


    NDST2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): NDST2
    Human Genome Epidemiology (HuGE) Navigator: NDST2 (1 document)

    Export disorders for NDST2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDST2 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with NDST2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2. (PubMed id 9601056)1, 2, 3 Humphries D.E.... Karlinsky J.B. (1998)
    2. Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2. (PubMed id 16343444)1, 2, 9 Duncan M.B.... Liu J. (2006)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Influence of high glucose concentrations on the expression of glycosaminoglycans and N-deacetylase/N-sulphotransferase mRNA in cultured skin fibroblasts from diabetic patients with or without nephropathy. (PubMed id 11865082)1, 9 Yard B....van Der Woude F. (2002)
    6. Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2. (PubMed id 12634318)2 van den Born J....Berden J.H.M. (2003)
    7. Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. (PubMed id 12876215)1 Carter N.M....Kirby J.A. (2003)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Order out of chaos: assembly of ligand binding sites in heparan sulfate. (PubMed id 12045103)1 Esko J.D. and Selleck S.B. (2002)
    10. Overexpression of different isoforms of glucosaminyl N-deacetylase/N- sulfotransferase results in distinct heparan sulfate N-sulfation patterns. (PubMed id 10758005)2 Pikas D.S.... Kjellen L. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8509 HGNC: 7681 AceView: NDST2 Ensembl:ENSG00000166507 euGenes: HUgn8509
    ECgene: NDST2 Kegg: 8509 H-InvDB: NDST2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDST2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDST2 gene:
    Search GeneIP for patents involving NDST2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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