NDST2 Gene
protein-coding GIFtS: 57
GCID: GC10M075561
|
|
N-deacetylase/N-sulfotransferase (heparan glucosaminyl)...
| |
Aliases
for NDST2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 21 2 | | N-Heparan Sulfate Sulfotransferase 22 3 | | HSST21 2 3 | | N-HSST 22 3 | | NST21 2 | | Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 22 | | Glucosaminyl N-Deacetylase/N-Sulfotransferase 22 3 | | EC 2.8.2.83 | | NDST-22 3 | | |
Export aliases for NDST2 gene to outside databasesPrevious GC identifers: GC10M074340 GC10M074665 GC10M075454 GC10M074906 GC10M075231 GC10M069557 |
Summaries
for NDST2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NDST2:
This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. Theencoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation andN-sulfation. The encoded protein may be localized to the Golgi. (provided by RefSeq, Feb 2009)
UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine(GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backboneto make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a rolein determining the extent and pattern of sulfation of heparan sulfate
Gene Wiki entry for NDST2
|
Genomic Views
for NDST2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDST2 gene promoter:
GR Nkx3-1 v4 Nkx2-5 AP-2gamma Egr-4 AP-2beta Nkx3-1 v3 GR-alpha AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDST2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDST2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22 Ensembl cytogenetic band: 10q22.2 HGNC cytogenetic band: 10q22NDST2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M075561: view genomic region
(about GC identifiers)
Start:
|
75,561,669 bp from pter |
End:
|
75,571,589 bp from pter |
Size:
|
9,921 bases |
Orientation:
|
minus strand |
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Proteins
for NDST2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849 (See
protein sequence)Recommended Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 Size: 883 amino acids; 100875 Da
Subunit: Monomer (By similarity)
Subcellular location: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
Miscellaneous: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as wellas differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation reactions,whereas other later on fill in or extend already modified heparan sulfate sequences
Secondary accessions: Q2TB32 Q59H89Alternative splicing: 2 isoforms: P52849-1 P52849-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for NDST2: NX_P52849
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P52849
NDST2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003626.1
ENSEMBL proteins: ENSP00000310657 ENSP00000392733 ENSP00000299641 Reactome Protein details: P52849
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
NDST2 for ontologies About GeneDecksing
NDST2 Antibody Products:
Assay Products for NDST2: |
Protein
Domains /
Families
for NDST2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NDST2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P52849ProtoNet protein and cluster: P52849 UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849Similarity: Belongs to the sulfotransferase 1 family. NDST subfamily |
Function
for NDST2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine(GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backboneto make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a rolein determining the extent and pattern of sulfation of heparan sulfateCatalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +[heparan sulfate]-N-sulfoglucosamineBiophysicochemical properties: Kinetic parameters: KM=4.7 uM for K5 polysaccharide; KM=0.76 uM for N-acetylated HS-II; Genatlas biochemistry entry for NDST2:heparan sulfate-N-deacetylase/N-sulfotransferase 2,with two alternative forms,predominantly expressed inheart,liver,pancreas,located to the trans-Golgi network
Enzyme Number (IUBMB): EC 2.8.2.81
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDST2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDST2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NDST2 (NM_003635) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDST2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDST2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDST2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008146 | sulfotransferase activity |
-- | -- | | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity |
IEA | -- | | GO:0019213 | deacetylase activity |
IEA | -- |
NDST2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for NDST2: Ndst2tm1Lex Ndst2tm1Lkj Ndst2tm1Rls
8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ndst2):
NDST2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NDST2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MPS IIIC - Sanfilippo syndrome C | | | 2 | heparan sulfate biosynthesis | | | 3 | Metabolism | | | 4 | Disease | | | 5 | Biological oxidations | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for NDST2
5/18 
Reactome Pathways for NDST2 (see all 18)
2 
Kegg Pathways (Kegg details for NDST2):
UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849Pathway: Glycan metabolism; heparan sulfate biosynthesisPathway: Glycan metabolism; heparin biosynthesis
NDST2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDST2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/26 Interacting proteins for NDST2 (P528493 ENSP000002996414) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002002 | regulation of angiotensin levels in blood |
IEA | -- | | GO:0005975 | carbohydrate metabolic process |
TAS | -- | | GO:0006024 | glycosaminoglycan biosynthetic process |
TAS | -- | | GO:0009987 | cellular process |
-- | -- | | GO:0015012 | heparan sulfate proteoglycan biosynthetic process |
IEA | -- |
NDST2 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDST2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NDST2
Search CenterWatch for drugs/clinical trials and news about NDST2
|
Transcripts
for NDST2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NDST2 gene: NM_003635.3 Unigene Cluster for NDST2: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 Hs.654758 [show with all ESTs]Unigene Representative Sequence: NM_0036355 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000309979(uc010qks.1 uc001jvl.1 uc009xro.2 uc010qku.1)
ENST00000429742 ENST00000463410 ENST00000465929 ENST00000299641(uc001jvk.2 uc010qkt.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDST2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDST2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NDST2 (NM_003635) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NDST2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDST2 |
Additional cDNA sequence: AK293527.1 AK298957.1 AK300520.1 AK301251.1 AK303648.1 BC035711.1 BC110588.1 BC110589.1 U36601.1 8 DOTS entries: DT.116794 DT.91864741 DT.92013689 DT.91688062 DT.91742477 DT.91714064 DT.121293091 DT.95119037 24/158 AceView cDNA sequences (see all 158): W24510 CA405478 CR625829 AI354728 BU730523 AW074575 AA428738 AA934803 AI088376 BC035711 CK902419 BX342466 BF434496 BG055780 NM_003635 AA903589 CB144454 CF529390 AU125430 AL080182 T32268 AL079419 U36601 AA428321
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NDST2 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NDST2
|
Expression
for NDST2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NDST2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAGGGACCC
About this image
See NDST2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NDST2
SOURCE GeneReport for Unigene cluster: Hs.654758
SABiosciences Custom PCR Arrays for NDST2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDST2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NDST2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDST2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDST2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDST2 |
Orthologs
for NDST2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NDST2 gene from 5/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
NDST21 |
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more |
74.95(n)
83.28(a) |
|
423738 XM_421613.3 XP_421613.2 |
lizard
(Anolis carolinensis) |
Reptilia |
NDST26 |
-- |
81(a) |
1 ↔ 1 |
GL343196.1(1421790-1445840) |
zebrafish
(Danio rerio) |
Actinopterygii |
ndst2a1 |
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more |
71.16(n)
76.6(a) |
|
793524 XM_001924015.2 XP_001924050.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
sfl1 , 3 |
cell surface receptor linked signal
transduction more3
sulfateless1 |
54(a)3
56.51(n)1
55.66(a)1 |
|
387361 NM_079222.31 NP_523946.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
hst-11 , 3 |
N-heparan sulfate sulfotransferase3
Protein HST-11 |
43(a)3
50.33(n)1
46.29(a)1 |
|
IV(8688631-8691631)3
1776751 NM_069090.31 NP_501491.31 |
ENSEMBL Gene Tree for NDST2 (if available)
TreeFam Gene Tree for NDST2 (if available) |
Paralogs
for NDST2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NDST2 gene
- HS3ST22 HS3ST12 HS3ST3B12 HS3ST42 HS3ST62 HS3ST3A12 HS3ST52 NDST12
- NDST42 NDST32
6 SIMAP similar genes for NDST2 using alignment to 3 protein entries: NDST2_HUMAN (see all proteins):NDST4 NDST1 NDST3 HS3ST3A1 HS3ST1 HS3ST4
NDST2 for paralogs About GeneDecksing
|
Genomic Variants
for NDST2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NDST2 (75561669 - 75571589 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NDST2
1 CNV: 48629 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDST2 |
|
Disorders
/ Diseases
for NDST2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDST2 for disorders About GeneDecksing
OMIM gene information: 603268
OMIM disorders: --
3  diseases for NDST2: About MalaCardshermaphroditism alzheimer's disease nephropathy
Human Genome Epidemiology (HuGE) Navigator: NDST2 (1 document)
Export disorders for NDST2 gene to outside databases
|
Publications
for NDST2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NDST2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with NDST2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2. (PubMed id 9601056)1, 2, 3 Humphries D.E.... Karlinsky J.B. (1998)
- Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2. (PubMed id 16343444)1, 2, 9 Duncan M.B.... Liu J. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Influence of high glucose concentrations on the expression of glycosaminoglycans and N-deacetylase/N-sulphotransferase mRNA in cultured skin fibroblasts from diabetic patients with or without nephropathy. (PubMed id 11865082)1, 9 Yard B....van Der Woude F. (2002)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2. (PubMed id 12634318)2 van den Born J....Berden J.H.M. (2003)
- Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. (PubMed id 12876215)1 Carter N.M....Kirby J.A. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Order out of chaos: assembly of ligand binding sites in heparan sulfate. (PubMed id 12045103)1 Esko J.D. and Selleck S.B. (2002)
- Overexpression of different isoforms of glucosaminyl N-deacetylase/N- sulfotransferase results in distinct heparan sulfate N-sulfation patterns. (PubMed id 10758005)2 Pikas D.S.... Kjellen L. (2000)
|
External Searches for NDST2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDST2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDST2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDST2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NDST2 | Pharmacogenomics, SNPs, Pathways | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ |
|
| | |
About This Section
| Patent Information for NDST2 gene:
Search GeneIP for patents involving NDST2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDST2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NDST2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NDST2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NDST2 | | | OriGene Protein Over-expression Lysate for NDST2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NDST2 | | OriGene 3'-UTR Clone for NDST2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NDST2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NDST2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NDST2 | | OriGene Custom Protein Services for NDST2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NDST2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NDST2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDST2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NDST2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDST2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NDST2 |
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| | | | Search Tocris compounds for NDST2 |
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 | | | NDST2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDST2 |
|  |  |  | | | | ThermoFisher Antibodies for NDST2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDST2 |
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