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NDST2 Gene

protein-coding   GIFtS: 59
GCID: GC10M075561

N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl)...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 21 2     N-HSST 22 3
Glucosaminyl N-Deacetylase/N-Sulfotransferase 22 3     NST22
HSST22 3     Bifunctional Heparan Sulfate N-Deacetylase/N-Sulfotransferase 22
NDST-22 3     EC 2.8.2.83
N-Heparan Sulfate Sulfotransferase 22 3     

External Ids:    HGNC: 76811   Entrez Gene: 85092   Ensembl: ENSG000001665077   OMIM: 6032685   UniProtKB: P528493   

Export aliases for NDST2 gene to outside databases

Previous GC identifers: GC10M074340 GC10M074665 GC10M075454 GC10M074906 GC10M075231 GC10M069557


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDST2 Gene:
This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins.
The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation
and N-sulfation. The encoded protein may be localized to the Golgi. (provided by RefSeq, Feb 2009)

GeneCards Summary for NDST2 Gene:
NDST2 (N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2) is a protein-coding gene. Diseases associated with NDST2 include morquio syndrome b, and sly syndrome. GO annotations related to this gene include [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. An important paralog of this gene is HS3ST2.

UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849
Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
(GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
Plays a role in determining the extent and pattern of sulfation of heparan sulfate

Gene Wiki entry for NDST2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDST2 gene promoter:
         GR   Nkx3-1 v4   Nkx2-5   AP-2gamma   Egr-4   AP-2beta   Nkx3-1 v3   GR-alpha   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDST2 promoter sequence
   Search Chromatin IP Primers for NDST2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDST2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22

NDST2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDST2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M075561:  view genomic region     (about GC identifiers)

Start:
75,561,669 bp from pter      End:
75,571,589 bp from pter
Size:
9,921 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849 (See protein sequence)
Recommended Name: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2  
Size: 883 amino acids; 100875 Da
Subunit: Monomer (By similarity)
Miscellaneous: The presence of 4 different heparan sulfate N-deacetylase/N-sulfotransferase enzymes in mammals, as
well as differences in their enzyme activity suggest that some initiate heparan sulfate modification/sulfation
reactions, whereas other later on fill in or extend already modified heparan sulfate sequences
Secondary accessions: Q2TB32 Q59H89
Alternative splicing: 2 isoforms:  P52849-1   P52849-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDST2: NX_P52849

Explore proteomics data for NDST2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn233, Asn350, Asn400, Asn666, Asn726, Asn802
  • Modification sites at PhosphoSitePlus

  • See NDST2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003626.1  
    ENSEMBL proteins: 
     ENSP00000310657   ENSP00000392733   ENSP00000299641  
    Reactome Protein details: P52849

    NDST2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SULTM: Sulfotransferases, membrane-bound

    3 InterPro protein domains:
     IPR000863 Sulfotransferase_dom
     IPR027417 P-loop_NTPase
     IPR021930 Heparan_SO4_deacetylase

    Graphical View of Domain Structure for InterPro Entry P52849

    ProtoNet protein and cluster: P52849

    UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849
    Similarity: Belongs to the sulfotransferase 1 family. NDST subfamily


    NDST2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDST2_HUMAN, P52849
    Function: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine
    (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar
    backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis.
    Plays a role in determining the extent and pattern of sulfation of heparan sulfate
    Catalytic activity: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate +
    [heparan sulfate]-N-sulfoglucosamine
    Biophysicochemical properties: Kinetic parameters: KM=4.7 uM for K5 polysaccharide; KM=0.76 uM for N-acetylated
    HS-II;

         Genatlas biochemistry entry for NDST2:
    heparan sulfate-N-deacetylase/N-sulfotransferase 2,with two alternative forms,predominantly expressed in
    heart,liver,pancreas,located to the trans-Golgi network

         Enzyme Number (IUBMB): EC 2.8.2.81

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008146sulfotransferase activity ----
    GO:0015016[heparan sulfate]-glucosamine N-sulfotransferase activity IEA--
    GO:0016787hydrolase activity IEA--
    GO:0019213deacetylase activity ----
         
    NDST2 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ndst2):
     embryogenesis  endocrine/exocrine gland  hematopoietic system  immune system  mortality/aging 
     skeleton  vision/eye 

    NDST2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NDST2: Ndst2tm1Lex Ndst2tm1Lkj Ndst2tm1Rls

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDST2
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NDST2 (see all 15):
    hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-1257 hsa-let-7i hsa-miR-3162-5p
    SwitchGear 3'UTR luciferase reporter plasmidNDST2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDST2_HUMAN, P52849: Golgi apparatus membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    extracellular2
    cytosol1
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus ----
    GO:0016021integral component of membrane IEA--

    NDST2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDST2 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1heparan sulfate biosynthesis
    heparan sulfate biosynthesis0.79
    heparan sulfate biosynthesis (late stages)0.00
    Glycosaminoglycan biosynthesis - heparan sulfate / heparin0.79
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    4Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    HS-GAG biosynthesis0.57
    5Biological oxidations
    metapathway biotransformation0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NDST2
        heparan sulfate biosynthesis (late stages)
    metapathway biotransformation
    heparan sulfate biosynthesis

    1 Reactome Pathway for NDST2
        HS-GAG biosynthesis


    2 Kegg Pathways  (Kegg details for NDST2):
        Glycosaminoglycan biosynthesis - heparan sulfate / heparin
    Metabolic pathways

    UniProtKB/Swiss-Prot: NDST2_HUMAN, P52849
    Pathway: Glycan metabolism; heparan sulfate biosynthesis
    Pathway: Glycan metabolism; heparin biosynthesis


    NDST2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDST2
    Interactions:

        Search GeneGlobe Interaction Network for NDST2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDST2 (P528493 ENSP000002996414) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPC5P783333, ENSP000003662674I2D: score=1 STRING: ENSP00000366267
    FGFR3P226073, ENSP000002607954I2D: score=1 STRING: ENSP00000260795
    CDC27P302603I2D: score=4 
    GRB2P629933I2D: score=2 
    GLCEENSP000002618584STRING: ENSP00000261858
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002002regulation of angiotensin levels in blood ----
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006024glycosaminoglycan biosynthetic process TAS--
    GO:0009987cellular process ----
    GO:0015012heparan sulfate proteoglycan biosynthetic process IEA--

    NDST2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDST2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NDST2 gene: 
    NM_003635.3  

    Unigene Cluster for NDST2:

    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
    Hs.654758  [show with all ESTs]
    Unigene Representative Sequence: NM_003635
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309979(uc010qks.1 uc001jvl.1 uc009xro.2 uc010qku.1)
    ENST00000429742 ENST00000463410 ENST00000465929 ENST00000398701 ENST00000299641(uc001jvk.2 uc010qkt.1)

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    hsa-miR-98 hsa-miR-1321 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-1257 hsa-let-7i hsa-miR-3162-5p
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    Additional mRNA sequence: 

    AK293527.1 AK298957.1 AK300520.1 AK301251.1 AK303648.1 BC035711.1 BC110588.1 BC110589.1 
    U36601.1 

    8 DOTS entries:

    DT.116794  DT.91864741  DT.92013689  DT.91688062  DT.91742477  DT.91714064  DT.121293091  DT.95119037 

    Selected AceView cDNA sequences (see all 158):

    BG055780 BU730523 BX342466 W24510 T32268 AW074575 AL079419 CA405478 
    CK902419 AA903589 AA428738 AA934803 AI354728 AU125430 BC035711 CR625829 
    U36601 CB144454 NM_003635 AI088376 AL080182 BF434496 CF529390 BC018681 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDST2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b
    SP1:                          -           -                                                                                               -               
    SP2:                                                                                                                    -                                 
    SP3:                                                                                                                    -                 -               
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for NDST2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDST2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGAGGGACCC
    NDST2 Expression
    About this image

    NDST2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDST2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654758
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDST2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDST2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndst21 , 5 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more1, 5 91.51(n)1
    96.72(a)1
      14 (11.53 cM)5
    174231  NM_010811.21  NP_034941.21 
     207237395 
    chicken
    (Gallus gallus)
    Aves NDST21 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 74.15(n)
    82.55(a)
      423738  XM_421613.4  XP_421613.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    81(a)
    1 → many
    GL343196.1(1421790-1502256)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ndst21 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 71.08(n)
    79.48(a)
      100217321  NM_001142818.1  NP_001136290.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndst2a1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) more 70.77(n)
    76.08(a)
      793524  XM_001924015.3  XP_001924050.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sfl1 , 3 cell surface receptor linked signal
    transduction more3
    sulfateless1
    54(a)3
    56.65(n)1
    56.07(a)1
      387361  NM_079222.41  NP_523946.11 
    worm
    (Caenorhabditis elegans)
    Secernentea hst-11 , 3 N-heparan sulfate sulfotransferase3
    hst-11
    43(a)3
    49.28(n)1
    45.37(a)1
      IV(8688631-8691631)3
    1776751  NM_069090.41  NP_501491.41 


    ENSEMBL Gene Tree for NDST2 (if available)
    TreeFam Gene Tree for NDST2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDST2 gene
    HS3ST22  ENSG000002729162  HS3ST12  HS3ST3B12  HS3ST42  HS3ST62  HS3ST3A12  HS3ST52  
    NDST12  NDST42  NDST32  
    6 SIMAP similar genes for NDST2 using alignment to 5 protein entries:     NDST2_HUMAN (see all proteins):
    NDST4    NDST1    NDST3    HS3ST3A1    HS3ST1    HS3ST4

    NDST2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDST2 (see all 225)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426654651,2
    C--75563205(+) CAGCAC/TGGGTA 1 -- int10--------
    rs110007811,2
    C,H--75563243(+) CTCAAA/GCCTCA 1 -- int14Minor allele frequency- G:0.00NS EA 406
    rs1830583591,2
    --75563261(+) CTCCCA/TCTCTA 1 -- int10--------
    rs2006513711,2
    C--75563287(+) TCCCCC/GCTCCC 1 -- int10--------
    rs1873970921,2
    C--75563375(+) GCACTA/GTGATG 2 T I mis10--------
    rs1419485581,2
    C,F--75563467(+) AAATCA/TGTGCT 2 T syn12Minor allele frequency- T:0.00NA EU 5865
    rs2001328911,2
    --75563487(+) AGGAAA/CAGGGA 2 V F mis10--------
    rs1833349651,2
    --75563573(+) CTGTGC/TTGAGG 1 -- int10--------
    rs746662011,2
    C,F--75563600(+) ATTTTG/CGGGGA 1 -- int11Minor allele frequency- C:0.02EU 731
    rs755381231,2
    C--75563667(+) CTTGTG/CGTAAT 2 /H /D mis12Minor allele frequency- C:0.00NA EU 5465

    HapMap Linkage Disequilibrium report for NDST2 (75561669 - 75571589 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NDST2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv46n21CNV Loss19592680
    nsv825468CNV Gain20364138
    nsv831912CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDST2
    DNA2.0 Custom Variant and Variant Library Synthesis for NDST2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603268    OMIM disorders: --

    6 diseases for NDST2:    
    About MalaCards
    morquio syndrome b    sly syndrome    mucopolysaccharidoses    malaria
    alzheimer's disease    endotheliitis


    NDST2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NDST2
    Human Genome Epidemiology (HuGE) Navigator: NDST2 (1 document)

    Export disorders for NDST2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDST2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with NDST2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, genomic organization and chromosomal localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase-2. (PubMed id 9601056)1, 2, 3 Humphries D.E.... Karlinsky J.B. (Biochem. J. 1998)
    2. Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2. (PubMed id 16343444)1, 2, 9 Duncan M.B.... Liu J. (Biochem. Biophys. Res. Commun. 2006)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Influence of high glucose concentrations on the expression of glycosaminoglycans and N-deacetylase/N-sulphotransferase mRNA in cultured skin fibroblasts from diabetic patients with or without nephropathy. (PubMed id 11865082)1, 9 Yard B....van Der Woude F. (Nephrol. Dial. Transplant. 2002)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2. (PubMed id 12634318)2 van den Born J....Berden J.H.M. (Glycobiology 2003)
    8. Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate. (PubMed id 12876215)1 Carter N.M....Kirby J.A. (J. Cell. Sci. 2003)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Order out of chaos: assembly of ligand binding sites in heparan sulfate. (PubMed id 12045103)1 Esko J.D. and Selleck S.B. (Annu. Rev. Biochem. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8509 HGNC: 7681 AceView: NDST2 Ensembl:ENSG00000166507 euGenes: HUgn8509
    ECgene: NDST2 Kegg: 8509 H-InvDB: NDST2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDST2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=NDST2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDST2 gene:
    Search GeneIP for patents involving NDST2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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