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NDRG4 Gene

protein-coding   GIFtS: 55
GCID: GC16P058497

NDRG Family Member 4

  See NDRG4-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NDRG Family Member 41 2     N-Myc Downstream-Regulated Gene 4 Protein2 3
Brain Development-Related Molecule 12 3     SMAP82 5
Vascular Smooth Muscle Cell-Associated Protein 82 3     KIAA11803 5
BDM12 3     Protein NDRG42
SMAP-82 3     Smooth Muscle-Associated Protein 82

External Ids:    HGNC: 144661   Entrez Gene: 650092   Ensembl: ENSG000001030347   OMIM: 6144635   UniProtKB: Q9ULP03   

Export aliases for NDRG4 gene to outside databases

Previous GC identifers: GC16P048891 GC16P058581 GC16P058232 GC16P058273 GC16P057056 GC16P044366


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDRG4 Gene:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase
superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle
progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in
vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different
isoforms.(provided by RefSeq, Jun 2011)

GeneCards Summary for NDRG4 Gene:
NDRG4 (NDRG family member 4) is a protein-coding gene. Diseases associated with NDRG4 include motor peripheral neuropathy. An important paralog of this gene is NDRG2.

UniProtKB/Swiss-Prot: NDRG4_HUMAN, Q9ULP0
Function: Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary
for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By
similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and
FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner

Gene Wiki entry for NDRG4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDRG4 gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NDRG4 promoter sequence
   Search Chromatin IP Primers for NDRG4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDRG4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21-q22.1   Ensembl cytogenetic band:  16q21   HGNC cytogenetic band: 16q21-q22.3

NDRG4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDRG4 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P058497:  view genomic region     (about GC identifiers)

Start:
58,496,750 bp from pter      End:
58,547,532 bp from pter
Size:
50,783 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NDRG4_HUMAN, Q9ULP0 (See protein sequence)
Recommended Name: Protein NDRG4  
Size: 352 amino acids; 38459 Da
Developmental stage: Expressed in a cell cycle-specific manner in glioblastoma multiple cells. Low levels in G2/M
cells increase with progression through G1 phase and entry and progression through S phase
Sequence caution: Sequence=BAA86494.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KNU2 B4DK66 B4DSW5 H7C600 Q6ZNE7 Q6ZTI7 Q96PL9 Q9GZM1 Q9GZN3 Q9GZX0
Alternative splicing: 8 isoforms:  Q9ULP0-1   Q9ULP0-2   Q9ULP0-3   Q9ULP0-4   Q9ULP0-5   Q9ULP0-6   Q9ULP0-7   Q9ULP0-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDRG4: NX_Q9ULP0

Explore proteomics data for NDRG4 at MOPED

Post-translational modifications: 

  • Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NDRG4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (7 alternative transcripts): 
    NP_001123959.1  NP_001229762.1  NP_001229763.1  NP_001229764.1  NP_001229765.1  NP_065198.1  NP_075061.1  

    ENSEMBL proteins: 
     ENSP00000454745   ENSP00000454956   ENSP00000455465   ENSP00000258187   ENSP00000454893  
     ENSP00000457435   ENSP00000454216   ENSP00000454693   ENSP00000454509   ENSP00000377823  
     ENSP00000457638   ENSP00000455054   ENSP00000458092   ENSP00000455324   ENSP00000454274  
     ENSP00000454767   ENSP00000456583   ENSP00000456400   ENSP00000455660   ENSP00000456135  
     ENSP00000454410   ENSP00000457413   ENSP00000456338   ENSP00000454372   ENSP00000455518  
     ENSP00000455541   ENSP00000457119   ENSP00000349193   ENSP00000458113   ENSP00000455806  
     ENSP00000457659   ENSP00000456863   ENSP00000458032   ENSP00000457678   ENSP00000456641  
     ENSP00000454811   ENSP00000455421   ENSP00000454221   ENSP00000377820  

    NDRG4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NDRG4

     
    Search eBioscience for Proteins for NDRG4 

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    Cloud-Clone Corp. ELISAs for NDRG4
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    Search eBioscience for ELISAs for NDRG4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004142 Ndr

    Graphical View of Domain Structure for InterPro Entry Q9ULP0

    ProtoNet protein and cluster: Q9ULP0

    1 Blocks protein domain: IPB004142 Ndr family

    UniProtKB/Swiss-Prot: NDRG4_HUMAN, Q9ULP0
    Similarity: Belongs to the NDRG family


    Find genes that share domains with NDRG4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDRG4_HUMAN, Q9ULP0
    Function: Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary
    for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By
    similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and
    FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner

    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ndrg4):

     behavior/neurological  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with NDRG4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ndrg4tm1Myta for NDRG4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDRG4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDRG4
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NDRG4 (see all 32):
    hsa-miR-139-5p hsa-miR-219-5p hsa-miR-218 hsa-miR-508-3p hsa-miR-23a hsa-miR-3170 hsa-miR-130a* hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidNDRG4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): NDRG4 (NM_020465)
    Sino Biological Human cDNA Clone for NDRG4
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDRG4_HUMAN, Q9ULP0: Cytoplasm, cytosol
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    extracellular2
    plasma membrane2
    cytoskeleton1
    endoplasmic reticulum1
    golgi apparatus1
    lysosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm NAS11352569
    GO:0005829cytosol IEA--

    Find genes that share ontologies with NDRG4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDRG4 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    2PI3K / Akt Signaling
    PI3K / Akt Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy
    4Angiogenesis (CST)
    Angiogenesis


    Find genes that share SuperPaths with NDRG4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 Cell Signaling Technology (CST) Pathways for NDRG4
        Wnt / Hedgehog / Notch
    Apoptosis and Autophagy
    Angiogenesis
    PI3K / Akt Signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDRG4
    Interactions:

        Search GeneGlobe Interaction Network for NDRG4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for NDRG4 (ENSP000003778234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASENSP000003098454STRING: ENSP00000309845
    KRASENSP000002560784STRING: ENSP00000256078
    NRASENSP000003585484STRING: ENSP00000358548
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress NAS11352569
    GO:0016049cell growth NAS11352569
    GO:0030154cell differentiation NAS11352569

    Find genes that share ontologies with NDRG4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDRG4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDRG4 gene (7 alternative transcripts): 
    NM_001130487.1  NM_001242833.1  NM_001242834.1  NM_001242835.1  NM_001242836.1  NM_020465.3  NM_022910.3  

    Unigene Cluster for NDRG4:

    NDRG family member 4
    Hs.322430  [show with all ESTs]
    Unigene Representative Sequence: NM_001130487
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 55):
    ENST00000568999 ENST00000564207 ENST00000562764 ENST00000258187(uc002enk.3)
    ENST00000569404 ENST00000569539 ENST00000564126 ENST00000562725 ENST00000565304
    ENST00000567667 ENST00000394282(uc002enm.3) ENST00000566065 ENST00000564867
    ENST00000567454 ENST00000569578 ENST00000421602 ENST00000561779 ENST00000565430

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NDRG4 (see all 32):
    hsa-miR-139-5p hsa-miR-219-5p hsa-miR-218 hsa-miR-508-3p hsa-miR-23a hsa-miR-3170 hsa-miR-130a* hsa-miR-3120-3p
    SwitchGear 3'UTR luciferase reporter plasmidNDRG4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NDRG4
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NDRG4 (NM_020465)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDRG4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDRG4
    Primer
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    OriGene qPCR primer pairs and template standards for NDRG4
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDRG4
      QuantiTect SYBR Green Assays in human, mouse, rat NDRG4
      QuantiFast Probe-based Assays in human, mouse, rat NDRG4

    Additional mRNA sequence: 

    AB021172.1 AB033006.2 AB044944.1 AB044945.1 AB044946.1 AF007138.1 AF308608.1 AK055038.1 
    AK055148.1 AK124005.1 AK126574.1 AK126733.1 AK131248.1 AK296415.1 AK299949.1 AK316089.1 
    AL136584.1 BC001527.1 BC011795.2 CR936733.1 NR_040072.1 

    Selected DOTS entries (see all 42):

    DT.95099998  DT.100653420  DT.92437690  DT.100653425  DT.92437693  DT.100653426  DT.92437678  DT.101956135 
    DT.92437692  DT.120669981  DT.95099983  DT.101984403  DT.92437691  DT.100653422  DT.120670000  DT.101958074 
    DT.92437672  DT.120669979  DT.120670001  DT.120670063  DT.120669983  DT.120670011  DT.100677075  DT.120669987 

    Selected AceView cDNA sequences (see all 244):

    BC011795 AL136584 BQ716492 BM672992 CR601890 AA716227 AI922353 NM_020465 
    BQ716928 AB044945 AB044944 AB044946 AI922348 AI927448 H39664 CF552009 
    BX422804 CR623118 H06885 BQ719852 Z40384 NM_022910 BF447421 CK823304 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDRG4 (see all 24)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13 ^
    SP1:              -     -     -                 -     -     -     -     -     -     -     -                 -     -                                             
    SP2:                    -     -                 -     -     -     -     -     -     -     -                 -     -                                             
    SP3:                                                        -     -     -     -     -     -                 -     -                                             
    SP4:                                                        -     -     -     -     -     -                       -                                             
    SP5:                                                                                                        -     -                                             

    ExUns: 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
    SP1:                    -                                   -                                   -               
    SP2:                    -                                   -                                   -               
    SP3:                    -                                   -                                   -               
    SP4:                    -                                   -                                   -               
    SP5:                    -                                   -                                                   


    ECgene alternative splicing isoforms for NDRG4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDRG4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATGATAAA
    NDRG4 Expression
    About this image


    NDRG4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Gonad
             Primary Oocyte Primary Follicle
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Primary Oocyte Primary Follicle
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    NDRG4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDRG4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.322430

    UniProtKB/Swiss-Prot: NDRG4_HUMAN, Q9ULP0
    Tissue specificity: Expressed predominantly in brain and heart (at protein level). In the brain, detected in
    astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain.
    Up-regulated in glioblastoma multiforme cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NDRG4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndrg41 , 5 N-myc downstream regulated gene 41, 5 90.96(n)1
    97.59(a)1
      8 (47.12 cM)5
    2345931  NM_001195006.11  NP_001181935.11 
     956769805 
    chicken
    (Gallus gallus)
    Aves NDRG41 NDRG family member 4 84.79(n)
    92.31(a)
      768618  XM_001231664.3  XP_001231665.3 
    lizard
    (Anolis carolinensis)
    Reptilia NDRG46
    NDRG family member 4
    84(a)
    1 ↔ 1
    AAWZ02039020(290-9728)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD254301.12   -- 76.29(n)    CD254301.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndrg41 N-myc downstream regulated gene 4 77.81(n)
    86.45(a)
      692305  NM_001045173.2  NP_001038638.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MESK23   -- 42(a)   57E8   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G10A.33   -- 30(a)   I(13479864-13482231)   --


    ENSEMBL Gene Tree for NDRG4 (if available)
    TreeFam Gene Tree for NDRG4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDRG4 gene
    NDRG22  NDRG32  NDRG12  
    4 SIMAP similar genes for NDRG4 using alignment to 32 protein entries:     NDRG4_HUMAN (see all proteins):
    NDRG1    NDRG3    TRG14    NDRG2

    Find genes that share paralogs with NDRG4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDRG4 (see all 1202)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1487770791,2
    Cuntested158541713(+) ACAGCC/TGCAGA 15 R C mis10--------
    rs790814981,2
    C,F--44364834(+) TCCAAC/TAGAGT 1 -- us2k12Minor allele frequency- T:0.14NA 122
    rs116471071,2
    A,H--44407329(+) AAAAAA/CAAAAA 7 -- int10--------
    rs3713854701,2
    C--44407329(+) AAAAA-/A/AC  
            
    CAAAA
    7 -- int11CSA 2
    rs1817691861,2
    --58495578(+) CCTCAG/TGTGAT 1 -- us2k10--------
    rs1869705601,2
    --58495579(+) CTCAGG/TTGATC 1 -- us2k10--------
    rs740198811,2
    C,F--58495755(+) GCCACT/CGCAGA 1 -- us2k12Minor allele frequency- C:0.06WA 120
    rs1913910061,2
    --58495761(+) GCAGAC/TACCAT 1 -- us2k10--------
    rs740198821,2
    C,F--58495778(+) GACAGG/TCGTGT 1 -- us2k12Minor allele frequency- T:0.09WA 120
    rs1420022371,2
    C--58495779(+) ACAGGC/TGTGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NDRG4 (58496750 - 58547532 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NDRG4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527052CNV Loss19592680
    nsv528512CNV Loss19592680
    esv25662CNV Loss19812545
    dgv2876n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614463    OMIM disorders: --

    1 disease for NDRG4:    
    About MalaCards
    motor peripheral neuropathy

    1 disease from the University of Copenhagen DISEASES database for NDRG4:
    Motor peripheral neuropathy

    Find genes that share disorders with NDRG4           About GenesLikeMe

    Genetic Association Database (GAD): NDRG4
    Human Genome Epidemiology (HuGE) Navigator: NDRG4 (2 documents)

    Export disorders for NDRG4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDRG4 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with NDRG4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PubMed id 11352569)1, 2, 3, 9 Zhou R.-H.... Miyata T. (Genomics 2001)
    2. A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. (PubMed id 12755708)1, 2, 9 Nishimoto S.... Komurasaki T. (Eur. J. Biochem. 2003)
    3. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PubMed id 11936845)1, 2, 9 Qu X.... He F. (Mol. Cell. Biochem. 2002)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. NDRG4 is required for cell cycle progression and survival in glioblastoma cells. (PubMed id 19592488)1, 2 Schilling S.H.... Datto M.B. (J. Biol. Chem. 2009)
    6. Common variants at ten loci modulate the QT interval duration in the QTSCD Study. (PubMed id 19305409)1, 4 Pfeufer A.... Chakravarti A. (Nat. Genet. 2009)
    7. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PubMed id 19305408)1, 4 Newton-Cheh C.... Stricker B.H. (Nat. Genet. 2009)
    8. Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation. (PubMed id 16408304)1, 3 Hongo S....Miyazaki A. (J. Cell. Biochem. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65009 HGNC: 14466 AceView: NDRG4 Ensembl:ENSG00000103034 euGenes: HUgn65009
    ECgene: NDRG4 H-InvDB: NDRG4

    (According to HUGE)
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    HUGE: KIAA1180

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDRG4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDRG4 gene:
    Search GeneIP for patents involving NDRG4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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