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Aliases for NDRG4 Gene

Aliases for NDRG4 Gene

  • NDRG Family Member 4 2 3
  • Vascular Smooth Muscle Cell-Associated Protein 8 3 4
  • N-Myc Downstream-Regulated Gene 4 Protein 3 4
  • Brain Development-Related Molecule 1 3 4
  • KIAA1180 4 6
  • SMAP-8 3 4
  • SMAP8 3 6
  • BDM1 3 4
  • Smooth Muscle-Associated Protein 8 3
  • Protein NDRG4 3

External Ids for NDRG4 Gene

Summaries for NDRG4 Gene

Entrez Gene Summary for NDRG4 Gene

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]

GeneCards Summary for NDRG4 Gene

NDRG4 (NDRG Family Member 4) is a Protein Coding gene. Diseases associated with NDRG4 include motor peripheral neuropathy. Among its related pathways are Angiogenesis (CST) and Wnt / Hedgehog / Notch. An important paralog of this gene is NDRG2.

UniProtKB/Swiss-Prot for NDRG4 Gene

  • Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.

Gene Wiki entry for NDRG4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG4 Gene

Genomics for NDRG4 Gene

Genomic Location for NDRG4 Gene

Start:
58,462,846 bp from pter
End:
58,513,628 bp from pter
Size:
50,783 bases
Orientation:
Plus strand

Genomic View for NDRG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG4 Gene

Regulatory Elements for NDRG4 Gene

Transcription factor binding sites by QIAGEN in the NDRG4 gene promoter:

Proteins for NDRG4 Gene

  • Protein details for NDRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULP0-NDRG4_HUMAN
    Recommended name:
    Protein NDRG4
    Protein Accession:
    Q9ULP0
    Secondary Accessions:
    • B3KNU2
    • B4DK66
    • B4DSW5
    • H7C600
    • Q6ZNE7
    • Q6ZTI7
    • Q96PL9
    • Q9GZM1
    • Q9GZN3
    • Q9GZX0

    Protein attributes for NDRG4 Gene

    Size:
    352 amino acids
    Molecular mass:
    38459 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86494.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NDRG4 Gene

neXtProt entry for NDRG4 Gene

Proteomics data for NDRG4 Gene at MOPED

Post-translational modifications for NDRG4 Gene

  • Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDRG4 Gene

Domains for NDRG4 Gene

Protein Domains for NDRG4 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

NDRG4_HUMAN
Family:
  • Belongs to the NDRG family.:
    • Q9ULP0
genes like me logo Genes that share domains with NDRG4: view

No data available for Gene Families for NDRG4 Gene

Function for NDRG4 Gene

Molecular function for NDRG4 Gene

UniProtKB/Swiss-Prot Function: Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.

Gene Ontology (GO) - Molecular Function for NDRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NDRG4: view
genes like me logo Genes that share phenotypes with NDRG4: view

Animal Models for NDRG4 Gene

MGI Knock Outs for NDRG4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NDRG4 Gene

Localization for NDRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDRG4 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDRG4 Gene COMPARTMENTS Subcellular localization image for NDRG4 gene
Compartment Confidence
cytosol 5
extracellular 2
plasma membrane 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NDRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11352569
GO:0005739 mitochondrion ISS --
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0005829 cytosol IEA --
GO:0016323 basolateral plasma membrane IDA 19535783
genes like me logo Genes that share ontologies with NDRG4: view

Pathways for NDRG4 Gene

genes like me logo Genes that share pathways with NDRG4: view

Pathways by source for NDRG4 Gene

4 Cell Signaling Technology pathways for NDRG4 Gene

Gene Ontology (GO) - Biological Process for NDRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping ISS --
GO:0006950 response to stress NAS 11352569
GO:0007420 brain development IBA --
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IDA 12755708
GO:0010976 positive regulation of neuron projection development ISS --
genes like me logo Genes that share ontologies with NDRG4: view

Transcripts for NDRG4 Gene

Unigene Clusters for NDRG4 Gene

NDRG family member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13 ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - -
SP6:
SP7: - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - -
SP15:
SP16: - - - - - -
SP17: - - - - - -
SP18: - - - - -
SP19:
SP20:
SP21: - - - - -
SP22:
SP23:
SP24: - - - - - -

ExUns: 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20: - - - - - - - -
SP21:
SP22:
SP23:
SP24:

Relevant External Links for NDRG4 Gene

GeneLoc Exon Structure for
NDRG4
ECgene alternative splicing isoforms for
NDRG4

Expression for NDRG4 Gene

mRNA expression in normal human tissues for NDRG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDRG4 Gene

This gene is overexpressed in Heart - Left Ventricle (5.2), Brain - Cerebellum (4.4), and Brain - Frontal Cortex (BA9) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NDRG4 Gene

SOURCE GeneReport for Unigene cluster for NDRG4 Gene Hs.322430

mRNA Expression by UniProt/SwissProt for NDRG4 Gene

Q9ULP0-NDRG4_HUMAN
Tissue specificity: Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
genes like me logo Genes that share expressions with NDRG4: view

Orthologs for NDRG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDRG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDRG4 36
  • 99.4 (n)
  • 99.74 (a)
NDRG4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDRG4 36
  • 92.71 (n)
  • 98.12 (a)
NDRG4 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDRG4 36
  • 93.37 (n)
  • 98.8 (a)
NDRG4 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndrg4 36
  • 90.96 (n)
  • 97.59 (a)
Ndrg4 16
Ndrg4 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDRG4 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDRG4 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndrg4 36
  • 89.34 (n)
  • 95.65 (a)
chicken
(Gallus gallus)
Aves NDRG4 36
  • 84.79 (n)
  • 92.31 (a)
NDRG4 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDRG4 37
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg3 36
  • 76.84 (n)
  • 87.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ndrg4 36
  • 77.81 (n)
  • 86.45 (a)
ndrg4 37
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2082 37
  • 25 (a)
ManyToMany
MESK2 37
  • 28 (a)
ManyToMany
MESK2 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 37
  • 29 (a)
ManyToMany
ZK1073.1 37
  • 25 (a)
ManyToMany
Y48G10A.3 38
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 37
  • 35 (a)
OneToMany
Species with no ortholog for NDRG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG4 Gene

ENSEMBL:
Gene Tree for NDRG4 (if available)
TreeFam:
Gene Tree for NDRG4 (if available)

Paralogs for NDRG4 Gene

Paralogs for NDRG4 Gene

genes like me logo Genes that share paralogs with NDRG4: view

Variants for NDRG4 Gene

Sequence variations from dbSNP and Humsavar for NDRG4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs37038 -- 58,510,847(+) TGCAG(A/G)CTTGG intron-variant
rs40185 -- 58,506,691(-) GACAC(C/T)CGCCT intron-variant
rs40186 -- 58,511,164(+) GGCAC(A/G)GCTGG intron-variant
rs42944 -- 58,509,427(-) CTGCA(A/C)ACAGG intron-variant
rs42945 -- 58,511,522(+) CACTC(A/G)GAGAG reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NDRG4 Gene

Variant ID Type Subtype PubMed ID
esv25662 CNV Loss 19812545
nsv528512 CNV Loss 19592680
nsv527052 CNV Loss 19592680
dgv2876n71 CNV Loss 21882294

Relevant External Links for NDRG4 Gene

HapMap Linkage Disequilibrium report
NDRG4
Human Gene Mutation Database (HGMD)
NDRG4

Disorders for NDRG4 Gene

(1) University of Copenhagen DISEASES for NDRG4 Gene

Relevant External Links for NDRG4

Genetic Association Database (GAD)
NDRG4
Human Genome Epidemiology (HuGE) Navigator
NDRG4
genes like me logo Genes that share disorders with NDRG4: view

No data available for UniProtKB/Swiss-Prot for NDRG4 Gene

Publications for NDRG4 Gene

  1. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PMID: 11352569) Zhou R.-H. … Miyata T. (Genomics 2001) 2 3 4 23
  2. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X. … He F. (Mol. Cell. Biochem. 2002) 3 4 23
  3. A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. (PMID: 12755708) Nishimoto S. … Komurasaki T. (Eur. J. Biochem. 2003) 3 4 23
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for NDRG4 Gene

Sources for NDRG4 Gene

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