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Aliases for NDRG4 Gene

Aliases for NDRG4 Gene

  • NDRG Family Member 4 2 3 5
  • Vascular Smooth Muscle Cell-Associated Protein 8 3 4
  • N-Myc Downstream-Regulated Gene 4 Protein 3 4
  • Brain Development-Related Molecule 1 3 4
  • SMAP-8 3 4
  • BDM1 3 4
  • Smooth Muscle-Associated Protein 8 3
  • Protein NDRG4 3
  • KIAA1180 4
  • SMAP8 3

External Ids for NDRG4 Gene

Previous GeneCards Identifiers for NDRG4 Gene

  • GC16P048891
  • GC16P058581
  • GC16P058232
  • GC16P058273
  • GC16P057056
  • GC16P058497
  • GC16P044366

Summaries for NDRG4 Gene

Entrez Gene Summary for NDRG4 Gene

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]

GeneCards Summary for NDRG4 Gene

NDRG4 (NDRG Family Member 4) is a Protein Coding gene. Diseases associated with NDRG4 include Infantile Myofibromatosis and Reflex Epilepsy. Among its related pathways are Apoptosis and Autophagy and Angiogenesis (CST). An important paralog of this gene is MIR6717.

UniProtKB/Swiss-Prot for NDRG4 Gene

  • Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.

Gene Wiki entry for NDRG4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG4 Gene

Genomics for NDRG4 Gene

Regulatory Elements for NDRG4 Gene

Enhancers for NDRG4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around NDRG4 on UCSC Golden Path with GeneCards custom track

Promoters for NDRG4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the NDRG4 gene promoter:

Genomic Location for NDRG4 Gene

Chromosome:
16
Start:
58,462,846 bp from pter
End:
58,513,628 bp from pter
Size:
50,783 bases
Orientation:
Plus strand

Genomic View for NDRG4 Gene

Genes around NDRG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG4 Gene

Proteins for NDRG4 Gene

  • Protein details for NDRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULP0-NDRG4_HUMAN
    Recommended name:
    Protein NDRG4
    Protein Accession:
    Q9ULP0
    Secondary Accessions:
    • B3KNU2
    • B4DK66
    • B4DSW5
    • H7C600
    • Q6ZNE7
    • Q6ZTI7
    • Q96PL9
    • Q9GZM1
    • Q9GZN3
    • Q9GZX0

    Protein attributes for NDRG4 Gene

    Size:
    352 amino acids
    Molecular mass:
    38459 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86494.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NDRG4 Gene

neXtProt entry for NDRG4 Gene

Post-translational modifications for NDRG4 Gene

  • Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NDRG4 Gene

Domains & Families for NDRG4 Gene

Protein Domains for NDRG4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDRG4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULP0

UniProtKB/Swiss-Prot:

NDRG4_HUMAN :
  • Belongs to the NDRG family.
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG4: view

No data available for Gene Families for NDRG4 Gene

Function for NDRG4 Gene

Molecular function for NDRG4 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.

Gene Ontology (GO) - Molecular Function for NDRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NDRG4: view
genes like me logo Genes that share phenotypes with NDRG4: view

Animal Models for NDRG4 Gene

MGI Knock Outs for NDRG4:

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDRG4 Gene

Localization for NDRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDRG4 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDRG4 Gene COMPARTMENTS Subcellular localization image for NDRG4 gene
Compartment Confidence
plasma membrane 5
cytosol 4
endoplasmic reticulum 4
mitochondrion 4
extracellular 2
nucleus 2
cytoskeleton 1
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NDRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11352569
GO:0005739 mitochondrion ISS --
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0005829 cytosol IEA --
GO:0016323 basolateral plasma membrane IDA 19535783
genes like me logo Genes that share ontologies with NDRG4: view

Pathways & Interactions for NDRG4 Gene

genes like me logo Genes that share pathways with NDRG4: view

Pathways by source for NDRG4 Gene

4 Cell Signaling Technology pathways for NDRG4 Gene

Gene Ontology (GO) - Biological Process for NDRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping ISS --
GO:0006950 response to stress NAS 11352569
GO:0007420 brain development IBA --
GO:0008542 visual learning IEA --
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IDA 12755708
genes like me logo Genes that share ontologies with NDRG4: view

No data available for SIGNOR curated interactions for NDRG4 Gene

Drugs & Compounds for NDRG4 Gene

No Compound Related Data Available

Transcripts for NDRG4 Gene

Unigene Clusters for NDRG4 Gene

NDRG family member 4:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13 ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - -
SP6:
SP7: - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - -
SP15:
SP16: - - - - - -
SP17: - - - - - -
SP18: - - - - -
SP19:
SP20:
SP21: - - - - -
SP22:
SP23:
SP24: - - - - - -

ExUns: 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20: - - - - - - - -
SP21:
SP22:
SP23:
SP24:

Relevant External Links for NDRG4 Gene

GeneLoc Exon Structure for
NDRG4
ECgene alternative splicing isoforms for
NDRG4

Expression for NDRG4 Gene

mRNA expression in normal human tissues for NDRG4 Gene

mRNA differential expression in normal tissues according to GTEx for NDRG4 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.2), Brain - Cerebellum (x4.4), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for NDRG4 Gene

This gene is overexpressed in Brain (11.7), Testis (10.9), Ovary (10.3), Fetal Brain (7.0), Frontal cortex (6.1), and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NDRG4 Gene



Protein tissue co-expression partners for NDRG4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDRG4 Gene:

NDRG4

SOURCE GeneReport for Unigene cluster for NDRG4 Gene:

Hs.322430

mRNA Expression by UniProt/SwissProt for NDRG4 Gene:

Q9ULP0-NDRG4_HUMAN
Tissue specificity: Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.
genes like me logo Genes that share expression patterns with NDRG4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NDRG4 Gene

Orthologs for NDRG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDRG4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDRG4 34
  • 92.71 (n)
  • 98.12 (a)
NDRG4 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDRG4 34
  • 93.37 (n)
  • 98.8 (a)
NDRG4 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndrg4 34
  • 90.96 (n)
  • 97.59 (a)
Ndrg4 16
Ndrg4 35
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDRG4 34
  • 99.4 (n)
  • 99.74 (a)
NDRG4 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndrg4 34
  • 89.34 (n)
  • 95.65 (a)
oppossum
(Monodelphis domestica)
Mammalia NDRG4 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NDRG4 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDRG4 34
  • 84.79 (n)
  • 92.31 (a)
NDRG4 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDRG4 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg3 34
  • 76.84 (n)
  • 87.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ndrg4 34
  • 77.81 (n)
  • 86.45 (a)
ndrg4 35
  • 83 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MESK2 36
  • 42 (a)
CG2082 35
  • 25 (a)
ManyToMany
MESK2 35
  • 28 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 36
  • 30 (a)
Y48G10A.3 35
  • 29 (a)
ManyToMany
ZK1073.1 35
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 35
  • 35 (a)
OneToMany
Species where no ortholog for NDRG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG4 Gene

ENSEMBL:
Gene Tree for NDRG4 (if available)
TreeFam:
Gene Tree for NDRG4 (if available)

Paralogs for NDRG4 Gene

Paralogs for NDRG4 Gene

genes like me logo Genes that share paralogs with NDRG4: view

Variants for NDRG4 Gene

Sequence variations from dbSNP and Humsavar for NDRG4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3048059 -- 58,507,501(+) AACAA(-/AACAA)TAGAG intron-variant
rs3048060 -- 58,509,959(+) acaca(-/CA)acaca intron-variant
rs3743566 -- 58,511,881(+) CCAGG(A/C/T)CATTC nc-transcript-variant, utr-variant-3-prime
rs3803581 -- 58,512,530(-) GCCTG(C/G)CCAGA nc-transcript-variant, utr-variant-3-prime
rs3840040 -- 58,513,169(-) CACAC(-/ACACACACAT)ATATA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NDRG4 Gene

Variant ID Type Subtype PubMed ID
esv25662 CNV loss 19812545
nsv1058290 CNV gain 25217958
nsv1126429 CNV deletion 24896259
nsv527052 CNV loss 19592680
nsv528512 CNV loss 19592680

Variation tolerance for NDRG4 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDRG4 Gene

Human Gene Mutation Database (HGMD)
NDRG4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDRG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG4 Gene

Disorders for NDRG4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NDRG4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
infantile myofibromatosis
reflex epilepsy
  • epilepsy, sensory-induced
glioblastoma
  • glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards
Search NDRG4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NDRG4

Genetic Association Database (GAD)
NDRG4
Human Genome Epidemiology (HuGE) Navigator
NDRG4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDRG4
genes like me logo Genes that share disorders with NDRG4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDRG4 Gene

Publications for NDRG4 Gene

  1. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PMID: 11352569) Zhou R.-H. … Miyata T. (Genomics 2001) 2 3 4 22 65
  2. A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. (PMID: 12755708) Nishimoto S. … Komurasaki T. (Eur. J. Biochem. 2003) 3 4 22 65
  3. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X. … He F. (Mol. Cell. Biochem. 2002) 3 4 22 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C. … Stricker B.H. (Nat. Genet. 2009) 3 46 65

Products for NDRG4 Gene

Sources for NDRG4 Gene

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