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Aliases for NDRG4 Gene

Aliases for NDRG4 Gene

  • NDRG Family Member 4 2 3 5
  • Vascular Smooth Muscle Cell-Associated Protein 8 3 4
  • N-Myc Downstream-Regulated Gene 4 Protein 3 4
  • Brain Development-Related Molecule 1 3 4
  • SMAP-8 3 4
  • BDM1 3 4
  • Smooth Muscle-Associated Protein 8 3
  • Protein NDRG4 3
  • KIAA1180 4
  • SMAP8 3

External Ids for NDRG4 Gene

Previous GeneCards Identifiers for NDRG4 Gene

  • GC16P048891
  • GC16P058581
  • GC16P058232
  • GC16P058273
  • GC16P057056
  • GC16P058497
  • GC16P044366

Summaries for NDRG4 Gene

Entrez Gene Summary for NDRG4 Gene

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.[provided by RefSeq, Jun 2011]

GeneCards Summary for NDRG4 Gene

NDRG4 (NDRG Family Member 4) is a Protein Coding gene. Diseases associated with NDRG4 include Infantile Myofibromatosis and Charcot-Marie-Tooth Disease, Type 4D. Among its related pathways are Wnt / Hedgehog / Notch and PI3K / Akt Signaling. An important paralog of this gene is NDRG2.

UniProtKB/Swiss-Prot for NDRG4 Gene

  • Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.

Gene Wiki entry for NDRG4 Gene

Additional gene information for NDRG4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG4 Gene

Genomics for NDRG4 Gene

GeneHancer (GH) Regulatory Elements for NDRG4 Gene

Promoters and enhancers for NDRG4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I058499 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 559.2 +38.0 38041 2.8 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A GLIS2 FOS ATF7 SP3 NDRG4 GC16M058500 RNU6-103P
GH16I058463 Promoter/Enhancer 1.6 EPDnew Ensembl dbSUPER 550.8 +0.9 862 0.6 MAZ SUZ12 ZNF10 ZNF398 ZIC2 ZFHX2 GLIS2 POLR2A GLIS1 PATZ1 NDRG4 GC16P058496
GH16I058464 Promoter/Enhancer 1 EPDnew dbSUPER 550.8 +1.4 1417 0.1 MAZ GLIS2 GLIS1 ZNF398 ZBTB26 EZH2 EGR2 NDRG4 GC16P058496
GH16I058466 Promoter/Enhancer 1 EPDnew dbSUPER 550.8 +1.9 1936 0.1 ZNF335 MAZ PATZ1 SIN3A ZEB1 EZH2 NDRG4 GC16P058496
GH16I057626 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 5.3 -834.1 -834061 4.8 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 ZNF766 ZNF302 ZNF416 ZNF207 ADGRG1 RSPRY1 LOC101927556 POLR2C NUP93 LOC105371286 SETD6 ADGRG3 CSNK2A2 CCDC102A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NDRG4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NDRG4 gene promoter:

Genomic Locations for NDRG4 Gene

Genomic Locations for NDRG4 Gene
chr16:58,462,846-58,513,628
(GRCh38/hg38)
Size:
50,783 bases
Orientation:
Plus strand
chr16:58,496,750-58,547,532
(GRCh37/hg19)

Genomic View for NDRG4 Gene

Genes around NDRG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG4 Gene

Proteins for NDRG4 Gene

  • Protein details for NDRG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULP0-NDRG4_HUMAN
    Recommended name:
    Protein NDRG4
    Protein Accession:
    Q9ULP0
    Secondary Accessions:
    • B3KNU2
    • B4DK66
    • B4DSW5
    • H7C600
    • Q6ZNE7
    • Q6ZTI7
    • Q96PL9
    • Q9GZM1
    • Q9GZN3
    • Q9GZX0

    Protein attributes for NDRG4 Gene

    Size:
    352 amino acids
    Molecular mass:
    38459 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA86494.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NDRG4 Gene

neXtProt entry for NDRG4 Gene

Post-translational modifications for NDRG4 Gene

  • Phosphorylated in an aortic smooth muscle cell line, following PDGF treatment.

No data available for DME Specific Peptides for NDRG4 Gene

Domains & Families for NDRG4 Gene

Gene Families for NDRG4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NDRG4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDRG4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULP0

UniProtKB/Swiss-Prot:

NDRG4_HUMAN :
  • Belongs to the NDRG family.
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG4: view

Function for NDRG4 Gene

Molecular function for NDRG4 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.

Phenotypes From GWAS Catalog for NDRG4 Gene

Gene Ontology (GO) - Molecular Function for NDRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NDRG4: view
genes like me logo Genes that share phenotypes with NDRG4: view

Animal Models for NDRG4 Gene

MGI Knock Outs for NDRG4:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDRG4 Gene

Localization for NDRG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDRG4 Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDRG4 gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
endoplasmic reticulum 4
cytosol 4
extracellular 2
nucleus 2
cytoskeleton 1
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NDRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11352569
GO:0005739 mitochondrion ISS --
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0005829 cytosol IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDRG4: view

Pathways & Interactions for NDRG4 Gene

genes like me logo Genes that share pathways with NDRG4: view

Pathways by source for NDRG4 Gene

4 Cell Signaling Technology pathways for NDRG4 Gene

Gene Ontology (GO) - Biological Process for NDRG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping ISS --
GO:0006950 response to stress NAS 11352569
GO:0007420 brain development IBA --
GO:0008542 visual learning IEA --
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IDA 12755708
genes like me logo Genes that share ontologies with NDRG4: view

No data available for SIGNOR curated interactions for NDRG4 Gene

Drugs & Compounds for NDRG4 Gene

No Compound Related Data Available

Transcripts for NDRG4 Gene

Unigene Clusters for NDRG4 Gene

NDRG family member 4:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG4 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b · 12c · 12d · 12e · 12f ^ 13 ^
SP1: - - - - - - - - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - -
SP6:
SP7: - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - - -
SP10: - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - - -
SP14: - -
SP15:
SP16: - - - - - -
SP17: - - - - - -
SP18: - - - - -
SP19:
SP20:
SP21: - - - - -
SP22:
SP23:
SP24: - - - - - -

ExUns: 14a · 14b · 14c ^ 15a · 15b · 15c ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: -
SP20: - - - - - - - -
SP21:
SP22:
SP23:
SP24:

Relevant External Links for NDRG4 Gene

GeneLoc Exon Structure for
NDRG4
ECgene alternative splicing isoforms for
NDRG4

Expression for NDRG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDRG4 Gene

mRNA differential expression in normal tissues according to GTEx for NDRG4 Gene

This gene is overexpressed in Heart - Left Ventricle (x5.2), Brain - Cerebellum (x4.4), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for NDRG4 Gene

This gene is overexpressed in Brain (11.7), Testis (10.9), Ovary (10.3), Fetal Brain (7.0), Frontal cortex (6.1), and Adrenal (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NDRG4 Gene



Protein tissue co-expression partners for NDRG4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDRG4 Gene:

NDRG4

SOURCE GeneReport for Unigene cluster for NDRG4 Gene:

Hs.322430

mRNA Expression by UniProt/SwissProt for NDRG4 Gene:

Q9ULP0-NDRG4_HUMAN
Tissue specificity: Expressed predominantly in brain and heart (at protein level). In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells.

Evidence on tissue expression from TISSUES for NDRG4 Gene

  • Nervous system(5)
  • Heart(4.6)
  • Muscle(4.5)
  • Spleen(4.3)
  • Kidney(3.3)
  • Adrenal gland(2.4)
  • Eye(2)
genes like me logo Genes that share expression patterns with NDRG4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDRG4 Gene

Orthologs for NDRG4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDRG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDRG4 33 34
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia NDRG4 33 34
  • 93.37 (n)
cow
(Bos Taurus)
Mammalia NDRG4 33 34
  • 92.71 (n)
oppossum
(Monodelphis domestica)
Mammalia NDRG4 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndrg4 33 16 34
  • 90.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NDRG4 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndrg4 33
  • 89.34 (n)
chicken
(Gallus gallus)
Aves NDRG4 33 34
  • 84.79 (n)
lizard
(Anolis carolinensis)
Reptilia NDRG4 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg3 33
  • 76.84 (n)
zebrafish
(Danio rerio)
Actinopterygii ndrg4 33 34
  • 77.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta MESK2 35 34
  • 42 (a)
CG2082 34
  • 25 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 35 34
  • 30 (a)
ZK1073.1 34
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 34
  • 35 (a)
OneToMany
Species where no ortholog for NDRG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG4 Gene

ENSEMBL:
Gene Tree for NDRG4 (if available)
TreeFam:
Gene Tree for NDRG4 (if available)

Paralogs for NDRG4 Gene

Variants for NDRG4 Gene

Sequence variations from dbSNP and Humsavar for NDRG4 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs606231463 uncertain-significance, not provided 58,504,632(+) G/A/C coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000032497 -- 58,467,014(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000069529 -- 58,485,218(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000092623 -- 58,490,282(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000121632 -- 58,484,947(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NDRG4 Gene

Variant ID Type Subtype PubMed ID
esv25662 CNV loss 19812545
nsv1058290 CNV gain 25217958
nsv1126429 CNV deletion 24896259
nsv527052 CNV loss 19592680
nsv528512 CNV loss 19592680

Variation tolerance for NDRG4 Gene

Residual Variation Intolerance Score: 36.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NDRG4 Gene

Human Gene Mutation Database (HGMD)
NDRG4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDRG4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG4 Gene

Disorders for NDRG4 Gene

MalaCards: The human disease database

(6) MalaCards diseases for NDRG4 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
infantile myofibromatosis
  • myofibromatosis
charcot-marie-tooth disease, type 4d
  • cmt4d
reflex epilepsy
  • epilepsy, sensory-induced
connective tissue benign neoplasm
  • neoplasm of soft tissue
glioblastoma
  • glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards
Search NDRG4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NDRG4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NDRG4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDRG4 Gene

Publications for NDRG4 Gene

  1. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PMID: 11352569) Zhou RH … Miyata T (Genomics 2001) 2 3 4 22 58
  2. A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells. (PMID: 12755708) Nishimoto S … Komurasaki T (European journal of biochemistry 2003) 3 4 22 58
  3. Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X … He F (Molecular and cellular biochemistry 2002) 3 4 22 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Common variants at ten loci influence QT interval duration in the QTGEN Study. (PMID: 19305408) Newton-Cheh C … Stricker BH (Nature genetics 2009) 3 44 58

Products for NDRG4 Gene

Sources for NDRG4 Gene

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