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Aliases for NDRG3 Gene

Aliases for NDRG3 Gene

  • NDRG Family Member 3 2 3 5
  • N-Myc Downstream-Regulated Gene 3 Protein 4

External Ids for NDRG3 Gene

Previous GeneCards Identifiers for NDRG3 Gene

  • GC20M035008
  • GC20M035918
  • GC20M035965
  • GC20M034713
  • GC20M035280
  • GC20M032016

Summaries for NDRG3 Gene

GeneCards Summary for NDRG3 Gene

NDRG3 (NDRG Family Member 3) is a Protein Coding gene. Diseases associated with NDRG3 include Charcot-Marie-Tooth Disease, Type 4D. Among its related pathways are Apoptosis and Autophagy and PI3K / Akt Signaling. An important paralog of this gene is NDRG1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG3 Gene

Genomics for NDRG3 Gene

Regulatory Elements for NDRG3 Gene

Enhancers for NDRG3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G036643 1.7 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +100.2 100189 4.1 PKNOX1 NFIB ZFP64 ARID4B ZNF362 CEBPB MIER2 TGIF2 NFIC SSRP1 NDRG3 SLA2 C20orf24 RBL1 SAMHD1 TGIF2 HNRNPA3P2
GH20G036676 1.6 FANTOM5 Ensembl ENCODE 11.3 +68.9 68930 1.5 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 SLC30A9 ZNF766 FOS NDRG3 MYL9 GC20M036652
GH20G036627 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +116.9 116856 3.5 SOX13 ATF1 FOXA2 MAX CEBPG ZBTB40 ZNF664 TCF12 ZFHX2 GATA2 C20orf24 NDRG3 MYL9 SLA2 RBL1 HNRNPA3P2
GH20G036772 1.1 ENCODE 15.7 -27.9 -27923 3.1 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NDRG3 DSN1 GC20P036795
GH20G036491 1.5 Ensembl ENCODE dbSUPER 10.6 +253.3 253308 3.3 HDGF ATF1 PKNOX1 ARNT ARID4B TCF12 ZNF766 GATA2 ELK1 ZNF143 MYL9 C20orf24 NDRG3 MROH8 GC20P036472 GC20P036530
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NDRG3 on UCSC Golden Path with GeneCards custom track

Promoters for NDRG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000136733 438 1801 CREB3L1 DMAP1 ZNF48 YY1 ETS1 TCF12 ZNF766 GLIS2 ZNF143 ZNF207

Genomic Location for NDRG3 Gene

36,651,766 bp from pter
36,746,138 bp from pter
94,373 bases
Minus strand

Genomic View for NDRG3 Gene

Genes around NDRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG3 Gene

Proteins for NDRG3 Gene

  • Protein details for NDRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NDRG3
    Protein Accession:
    Secondary Accessions:
    • A2A2S8
    • E1P5U7
    • E1P5U8
    • Q5TH32
    • Q96PL8
    • Q96SM2
    • Q9BXY7
    • Q9H3N7
    • Q9H411
    • Q9H8J6

    Protein attributes for NDRG3 Gene

    375 amino acids
    Molecular mass:
    41409 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NDRG3 Gene


neXtProt entry for NDRG3 Gene

Post-translational modifications for NDRG3 Gene

  • Ubiquitination at Lys13
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NDRG3 Gene

Domains & Families for NDRG3 Gene

Protein Domains for NDRG3 Gene


Suggested Antigen Peptide Sequences for NDRG3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NDRG family.
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG3: view

No data available for Gene Families for NDRG3 Gene

Function for NDRG3 Gene

Gene Ontology (GO) - Molecular Function for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NDRG3: view

Phenotypes for NDRG3 Gene

MGI mutant phenotypes for NDRG3:
inferred from 1 alleles
GenomeRNAi human phenotypes for NDRG3:
genes like me logo Genes that share phenotypes with NDRG3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NDRG3

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDRG3 Gene

Localization for NDRG3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDRG3 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11936845
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NDRG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NDRG3 Gene

Pathways & Interactions for NDRG3 Gene

genes like me logo Genes that share pathways with NDRG3: view

Pathways by source for NDRG3 Gene

3 Cell Signaling Technology pathways for NDRG3 Gene

Gene Ontology (GO) - Biological Process for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis NAS 11406283
GO:0030154 cell differentiation NAS 11406283
GO:0030308 negative regulation of cell growth NAS 11406283
genes like me logo Genes that share ontologies with NDRG3: view

No data available for SIGNOR curated interactions for NDRG3 Gene

Drugs & Compounds for NDRG3 Gene

No Compound Related Data Available

Transcripts for NDRG3 Gene

Unigene Clusters for NDRG3 Gene

NDRG family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG3 Gene

No ASD Table

Relevant External Links for NDRG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NDRG3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDRG3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for NDRG3 Gene

This gene is overexpressed in Frontal cortex (7.9) and Adrenal (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDRG3 Gene

Protein tissue co-expression partners for NDRG3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDRG3 Gene:


SOURCE GeneReport for Unigene cluster for NDRG3 Gene:


mRNA Expression by UniProt/SwissProt for NDRG3 Gene:

Tissue specificity: Ubiquitous. Highly expressed in brain.

Evidence on tissue expression from TISSUES for NDRG3 Gene

  • Spleen(4.3)
  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NDRG3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NDRG3 Gene

Orthologs for NDRG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDRG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NDRG3 34 35
  • 99.91 (n)
(Canis familiaris)
Mammalia NDRG3 34 35
  • 92.71 (n)
(Bos Taurus)
Mammalia NDRG3 34 35
  • 92.18 (n)
(Mus musculus)
Mammalia Ndrg3 34 16 35
  • 89.96 (n)
(Monodelphis domestica)
Mammalia NDRG3 35
  • 85 (a)
(Gallus gallus)
Aves NDRG3 35
  • 81 (a)
(Anolis carolinensis)
Reptilia NDRG3 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg4 34
  • 71.67 (n)
Str.7333 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.17664 34
(Danio rerio)
Actinopterygii ndrg3b 35
  • 78 (a)
ndrg3a 34 35
  • 71.34 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta MESK2 34 35
  • 51.89 (n)
CG2082 35
  • 26 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008821 34
  • 49.41 (n)
(Caenorhabditis elegans)
Secernentea Y48G10A.3 34 35
  • 47.68 (n)
ZK1073.1 35
  • 28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NDL1 34
  • 45.26 (n)
(Oryza sativa)
Liliopsida Os06g0563000 34
  • 46.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 35
  • 38 (a)
Species where no ortholog for NDRG3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG3 Gene

Gene Tree for NDRG3 (if available)
Gene Tree for NDRG3 (if available)

Paralogs for NDRG3 Gene

Paralogs for NDRG3 Gene

(4) SIMAP similar genes for NDRG3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NDRG3: view

Variants for NDRG3 Gene

Sequence variations from dbSNP and Humsavar for NDRG3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000052300 -- 36,699,353(+) TTTCA(A/G)TATCT intron-variant
rs1000059160 -- 36,747,158(+) GAGGC(A/G)GGCGC upstream-variant-2KB
rs1000077093 -- 36,654,132(+) CAACG(A/G)GACTA intron-variant
rs1000096508 -- 36,697,854(+) GTAAA(C/T)GATAA intron-variant, upstream-variant-2KB
rs1000107424 -- 36,739,963(+) TAATA(A/G)GTAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDRG3 Gene

Variant ID Type Subtype PubMed ID
esv2722377 CNV deletion 23290073
esv2722378 CNV deletion 23290073
esv2722379 CNV deletion 23290073
esv2722380 CNV deletion 23290073
esv3575371 CNV gain 25503493
esv992784 CNV insertion 20482838
nsv1057192 CNV loss 25217958
nsv1123484 CNV deletion 24896259
nsv833967 CNV loss 17160897

Variation tolerance for NDRG3 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDRG3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG3 Gene

Disorders for NDRG3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NDRG3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 4d
  • charcot-marie-tooth disease type 4d
- elite association - COSMIC cancer census association via MalaCards
Search NDRG3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NDRG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NDRG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDRG3 Gene

Publications for NDRG3 Gene

  1. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X. … He F. (Mol. Cell. Biochem. 2002) 3 4 22 64
  2. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PMID: 11352569) Zhou R.-H. … Miyata T. (Genomics 2001) 3 4 22 64
  3. Differential expression patterns of NDRG family proteins in the central nervous system. (PMID: 17998568) Okuda T. … Miyata T. (J. Histochem. Cytochem. 2008) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Cloning and expression pattern of the human NDRG3 gene. (PMID: 11406283) Zhao W. … Mao Y. (Biochim. Biophys. Acta 2001) 3 22 64

Products for NDRG3 Gene

Sources for NDRG3 Gene

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