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Aliases for NDRG3 Gene

Aliases for NDRG3 Gene

  • NDRG Family Member 3 2 3
  • N-Myc Downstream-Regulated Gene 3 Protein 4

External Ids for NDRG3 Gene

Previous GeneCards Identifiers for NDRG3 Gene

  • GC20M035008
  • GC20M035918
  • GC20M035965
  • GC20M034713
  • GC20M035280
  • GC20M032016

Summaries for NDRG3 Gene

GeneCards Summary for NDRG3 Gene

NDRG3 (NDRG Family Member 3) is a Protein Coding gene. Diseases associated with NDRG3 include motor peripheral neuropathy. Among its related pathways are Angiogenesis (CST) and Apoptosis and Autophagy. An important paralog of this gene is NDRG2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG3 Gene

Genomics for NDRG3 Gene

Regulatory Elements for NDRG3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDRG3 Gene

Start:
36,651,766 bp from pter
End:
36,746,138 bp from pter
Size:
94,373 bases
Orientation:
Minus strand

Genomic View for NDRG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG3 Gene

Proteins for NDRG3 Gene

  • Protein details for NDRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGV2-NDRG3_HUMAN
    Recommended name:
    Protein NDRG3
    Protein Accession:
    Q9UGV2
    Secondary Accessions:
    • A2A2S8
    • E1P5U7
    • E1P5U8
    • Q5TH32
    • Q96PL8
    • Q96SM2
    • Q9BXY7
    • Q9H3N7
    • Q9H411
    • Q9H8J6

    Protein attributes for NDRG3 Gene

    Size:
    375 amino acids
    Molecular mass:
    41409 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NDRG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDRG3 Gene

Proteomics data for NDRG3 Gene at MOPED

Post-translational modifications for NDRG3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDRG3 Gene

No data available for DME Specific Peptides for NDRG3 Gene

Domains for NDRG3 Gene

Protein Domains for NDRG3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDRG3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGV2

UniProtKB/Swiss-Prot:

NDRG3_HUMAN :
  • Q9UGV2
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG3: view

No data available for Gene Families for NDRG3 Gene

Function for NDRG3 Gene

Gene Ontology (GO) - Molecular Function for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with NDRG3: view

Phenotypes for NDRG3 Gene

MGI mutant phenotypes for NDRG3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NDRG3: view

Animal Model Products

CRISPR Products

miRNA for NDRG3 Gene

miRTarBase miRNAs that target NDRG3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDRG3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NDRG3 Gene

Localization for NDRG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDRG3 Gene COMPARTMENTS Subcellular localization image for NDRG3 gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11936845
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NDRG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NDRG3 Gene

Pathways for NDRG3 Gene

genes like me logo Genes that share pathways with NDRG3: view

Pathways by source for NDRG3 Gene

3 Cell Signaling Technology pathways for NDRG3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NDRG3 Gene

Gene Ontology (GO) - Biological Process for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0007283 spermatogenesis NAS 11406283
GO:0030154 cell differentiation NAS 11406283
GO:0030308 negative regulation of cell growth NAS 11406283
genes like me logo Genes that share ontologies with NDRG3: view

Transcripts for NDRG3 Gene

Unigene Clusters for NDRG3 Gene

NDRG family member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDRG3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG3 Gene

No ASD Table

Relevant External Links for NDRG3 Gene

GeneLoc Exon Structure for
NDRG3
ECgene alternative splicing isoforms for
NDRG3

Expression for NDRG3 Gene

mRNA expression in normal human tissues for NDRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDRG3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDRG3 Gene

SOURCE GeneReport for Unigene cluster for NDRG3 Gene Hs.437338

mRNA Expression by UniProt/SwissProt for NDRG3 Gene

Q9UGV2-NDRG3_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain.
genes like me logo Genes that share expressions with NDRG3: view

In Situ Assay Products

Orthologs for NDRG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDRG3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDRG3 35
  • 99.91 (n)
  • 100 (a)
NDRG3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NDRG3 35
  • 92.18 (n)
  • 96.27 (a)
NDRG3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDRG3 35
  • 92.71 (n)
  • 97.33 (a)
NDRG3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndrg3 35
  • 89.96 (n)
  • 96 (a)
Ndrg3 16
Ndrg3 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDRG3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDRG3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDRG3 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.17664 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg4 35
  • 71.67 (n)
  • 75.87 (a)
Str.7333 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ndrg3a 35
  • 71.34 (n)
  • 79.55 (a)
ndrg3a 36
  • 75 (a)
OneToMany
ndrg3b 36
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008821 35
  • 49.41 (n)
  • 43.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2082 36
  • 26 (a)
ManyToMany
MESK2 35
  • 51.89 (n)
  • 43.37 (a)
MESK2 36
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 35
  • 47.68 (n)
  • 34.77 (a)
Y48G10A.3 36
  • 31 (a)
ManyToMany
ZK1073.1 36
  • 28 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NDL1 35
  • 45.26 (n)
  • 33.58 (a)
rice
(Oryza sativa)
Liliopsida Os06g0563000 35
  • 46.36 (n)
  • 34.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 36
  • 38 (a)
OneToMany
Species with no ortholog for NDRG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG3 Gene

ENSEMBL:
Gene Tree for NDRG3 (if available)
TreeFam:
Gene Tree for NDRG3 (if available)

Paralogs for NDRG3 Gene

Paralogs for NDRG3 Gene

Selected SIMAP similar genes for NDRG3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NDRG3: view

Variants for NDRG3 Gene

Sequence variations from dbSNP and Humsavar for NDRG3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs170237 -- 36,696,925(+) atgaa(A/C)cttaa intron-variant
rs221306 -- 36,651,865(-) GACAG(A/G)CTGTT utr-variant-3-prime, nc-transcript-variant
rs221307 -- 36,686,638(-) AGAGT(C/T)ATAGG intron-variant
rs221311 -- 36,658,057(+) GGTTA(C/T)TGTAG intron-variant
rs221312 -- 36,668,971(+) gtctc(A/G)aatta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDRG3 Gene

Variant ID Type Subtype PubMed ID
nsv833967 CNV Loss 17160897
esv992784 CNV Insertion 20482838
esv2722377 CNV Deletion 23290073
esv2722378 CNV Deletion 23290073
esv2722379 CNV Deletion 23290073
esv2722380 CNV Deletion 23290073

Relevant External Links for NDRG3 Gene

HapMap Linkage Disequilibrium report
NDRG3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG3 Gene

Disorders for NDRG3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NDRG3 Gene including...

Search for NDRG3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NDRG3 Gene

genes like me logo Genes that share disorders with NDRG3: view

No data available for UniProtKB/Swiss-Prot for NDRG3 Gene

Publications for NDRG3 Gene

  1. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PMID: 11352569) Zhou R.-H. … Miyata T. (Genomics 2001) 3 4 23
  2. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X. … He F. (Mol. Cell. Biochem. 2002) 3 4 23
  3. Cloning and expression pattern of the human NDRG3 gene. (PMID: 11406283) Zhao W. … Mao Y. (Biochim. Biophys. Acta 2001) 3 23
  4. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. (PMID: 10831399) Kalaydjieva L. … Thomas P.K. (Am. J. Hum. Genet. 2000) 2 3
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4

Products for NDRG3 Gene

Sources for NDRG3 Gene

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