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Aliases for NDRG3 Gene

Aliases for NDRG3 Gene

  • NDRG Family Member 3 2 3 5
  • N-Myc Downstream-Regulated Gene 3 Protein 4

External Ids for NDRG3 Gene

Previous GeneCards Identifiers for NDRG3 Gene

  • GC20M035008
  • GC20M035918
  • GC20M035965
  • GC20M034713
  • GC20M035280
  • GC20M032016

Summaries for NDRG3 Gene

GeneCards Summary for NDRG3 Gene

NDRG3 (NDRG Family Member 3) is a Protein Coding gene. Diseases associated with NDRG3 include Transitional Papilloma. Among its related pathways are Apoptosis and Autophagy and PI3K / Akt Signaling. An important paralog of this gene is NDRG2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG3 Gene

Genomics for NDRG3 Gene

Regulatory Elements for NDRG3 Gene

Enhancers for NDRG3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NDRG3 on UCSC Golden Path with GeneCards custom track

Promoters for NDRG3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NDRG3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDRG3 Gene

Chromosome:
20
Start:
36,651,766 bp from pter
End:
36,746,138 bp from pter
Size:
94,373 bases
Orientation:
Minus strand

Genomic View for NDRG3 Gene

Genes around NDRG3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG3 Gene

Proteins for NDRG3 Gene

  • Protein details for NDRG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGV2-NDRG3_HUMAN
    Recommended name:
    Protein NDRG3
    Protein Accession:
    Q9UGV2
    Secondary Accessions:
    • A2A2S8
    • E1P5U7
    • E1P5U8
    • Q5TH32
    • Q96PL8
    • Q96SM2
    • Q9BXY7
    • Q9H3N7
    • Q9H411
    • Q9H8J6

    Protein attributes for NDRG3 Gene

    Size:
    375 amino acids
    Molecular mass:
    41409 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NDRG3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDRG3 Gene

Proteomics data for NDRG3 Gene at MOPED

Post-translational modifications for NDRG3 Gene

  • Ubiquitination at Lys 13
  • Modification sites at PhosphoSitePlus

Other Protein References for NDRG3 Gene

No data available for DME Specific Peptides for NDRG3 Gene

Domains & Families for NDRG3 Gene

Protein Domains for NDRG3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDRG3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGV2

UniProtKB/Swiss-Prot:

NDRG3_HUMAN :
  • Belongs to the NDRG family.
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG3: view

No data available for Gene Families for NDRG3 Gene

Function for NDRG3 Gene

Phenotypes for NDRG3 Gene

MGI mutant phenotypes for NDRG3:
inferred from 1 alleles
GenomeRNAi human phenotypes for NDRG3:
genes like me logo Genes that share phenotypes with NDRG3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NDRG3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NDRG3 Gene

Localization for NDRG3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDRG3 Gene COMPARTMENTS Subcellular localization image for NDRG3 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11936845
genes like me logo Genes that share ontologies with NDRG3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NDRG3 Gene

Pathways & Interactions for NDRG3 Gene

genes like me logo Genes that share pathways with NDRG3: view

Pathways by source for NDRG3 Gene

3 Cell Signaling Technology pathways for NDRG3 Gene

Interacting Proteins for NDRG3 Gene

Gene Ontology (GO) - Biological Process for NDRG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis NAS 11406283
GO:0030308 negative regulation of cell growth NAS 11406283
genes like me logo Genes that share ontologies with NDRG3: view

No data available for SIGNOR curated interactions for NDRG3 Gene

Drugs & Compounds for NDRG3 Gene

No Compound Related Data Available

Transcripts for NDRG3 Gene

Unigene Clusters for NDRG3 Gene

NDRG family member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG3 Gene

No ASD Table

Relevant External Links for NDRG3 Gene

GeneLoc Exon Structure for
NDRG3
ECgene alternative splicing isoforms for
NDRG3

Expression for NDRG3 Gene

mRNA expression in normal human tissues for NDRG3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NDRG3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for NDRG3 Gene

This gene is overexpressed in Frontal cortex (7.9) and Adrenal (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDRG3 Gene



SOURCE GeneReport for Unigene cluster for NDRG3 Gene Hs.437338

mRNA Expression by UniProt/SwissProt for NDRG3 Gene

Q9UGV2-NDRG3_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in brain.
genes like me logo Genes that share expression patterns with NDRG3: view

Protein tissue co-expression partners for NDRG3 Gene

- Elite partner

Primer Products

Orthologs for NDRG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDRG3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDRG3 35
  • 92.18 (n)
  • 96.27 (a)
NDRG3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDRG3 35
  • 92.71 (n)
  • 97.33 (a)
NDRG3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndrg3 35
  • 89.96 (n)
  • 96 (a)
Ndrg3 16
Ndrg3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDRG3 35
  • 99.91 (n)
  • 100 (a)
NDRG3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDRG3 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDRG3 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDRG3 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg4 35
  • 71.67 (n)
  • 75.87 (a)
Str.7333 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.17664 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ndrg3a 35
  • 71.34 (n)
  • 79.55 (a)
ndrg3a 36
  • 75 (a)
OneToMany
ndrg3b 36
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008821 35
  • 49.41 (n)
  • 43.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta MESK2 35
  • 51.89 (n)
  • 43.37 (a)
CG2082 36
  • 26 (a)
ManyToMany
MESK2 36
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 35
  • 47.68 (n)
  • 34.77 (a)
Y48G10A.3 36
  • 31 (a)
ManyToMany
ZK1073.1 36
  • 28 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NDL1 35
  • 45.26 (n)
  • 33.58 (a)
rice
(Oryza sativa)
Liliopsida Os06g0563000 35
  • 46.36 (n)
  • 34.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 36
  • 38 (a)
OneToMany
Species with no ortholog for NDRG3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG3 Gene

ENSEMBL:
Gene Tree for NDRG3 (if available)
TreeFam:
Gene Tree for NDRG3 (if available)

Paralogs for NDRG3 Gene

Paralogs for NDRG3 Gene

(4) SIMAP similar genes for NDRG3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NDRG3: view

Variants for NDRG3 Gene

Sequence variations from dbSNP and Humsavar for NDRG3 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs170237 -- 36,696,925(+) atgaa(A/C)cttaa intron-variant, upstream-variant-2KB
rs418739 -- 36,690,658(-) CTATT(C/G)GGTTC intron-variant
rs221306 -- 36,651,865(-) GACAG(A/G)CTGTT nc-transcript-variant, utr-variant-3-prime
rs221307 -- 36,686,638(-) AGAGT(C/T)ATAGG intron-variant
rs221311 -- 36,658,057(+) GGTTA(C/T)TGTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NDRG3 Gene

Variant ID Type Subtype PubMed ID
nsv833967 CNV Loss 17160897
esv992784 CNV Insertion 20482838
esv2722377 CNV Deletion 23290073
esv2722378 CNV Deletion 23290073
esv2722379 CNV Deletion 23290073
esv2722380 CNV Deletion 23290073

Variation tolerance for NDRG3 Gene

Residual Variation Intolerance Score: 29.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NDRG3 Gene

Disorders for NDRG3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NDRG3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
transitional papilloma
  • transitional cell papilloma
- elite association - COSMIC cancer census association via MalaCards
Search NDRG3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NDRG3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDRG3
genes like me logo Genes that share disorders with NDRG3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDRG3 Gene

Publications for NDRG3 Gene

  1. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X. … He F. (Mol. Cell. Biochem. 2002) 3 4 23 67
  2. Differential expression patterns of NDRG family proteins in the central nervous system. (PMID: 17998568) Okuda T. … Miyata T. (J. Histochem. Cytochem. 2008) 2 3
  3. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PMID: 11352569) Zhou R.-H. … Miyata T. (Genomics 2001) 3 23
  4. Cloning and expression pattern of the human NDRG3 gene. (PMID: 11406283) Zhao W. … Mao Y. (Biochim. Biophys. Acta 2001) 3 23
  5. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. (PMID: 10831399) Kalaydjieva L. … Thomas P.K. (Am. J. Hum. Genet. 2000) 2 3

Products for NDRG3 Gene

Sources for NDRG3 Gene

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