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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDRG3 Gene

protein-coding   GIFtS: 52
GCID: GC20M035280

NDRG Family Member 3

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
NDRG Family Member 31 2
N-Myc Downstream-Regulated Gene 3 Protein2 3
Protein NDRG32

External Ids:    HGNC: 144621   Entrez Gene: 574462   Ensembl: ENSG000001010797   OMIM: 6052735   UniProtKB: Q9UGV23   
ORGUL members:         
NONCODE14:n410908      

Export aliases for NDRG3 gene to outside databases

Previous GC identifers: GC20M035008 GC20M035918 GC20M035965 GC20M034713 GC20M032016


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NDRG3 Gene: 
NDRG3 (NDRG family member 3) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with NDRG3 include motor peripheral neuropathy, and peripheral neuropathy. GO annotations related to this gene include molecular_function. An important paralog of this gene is NDRG4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDRG3 gene promoter:
         MEF-2   Pax-6   HNF-3beta   LCR-F1   C/EBPalpha   E47   MEF-2A   Hand1   ARP-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNDRG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDRG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDRG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.21-q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.21-q11.23

NDRG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDRG3 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M035280:  view genomic region     (about GC identifiers)

Start:
35,280,169 bp from pter      End:
35,374,541 bp from pter
Size:
94,373 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NDRG3_HUMAN, Q9UGV2 (See protein sequence)
Recommended Name: Protein NDRG3  
Size: 375 amino acids; 41409 Da
Secondary accessions: A2A2S8 E1P5U7 E1P5U8 Q5TH32 Q96PL8 Q96SM2 Q9BXY7 Q9H3N7 Q9H411 Q9H8J6
Alternative splicing: 3 isoforms:  Q9UGV2-1   Q9UGV2-2   Q9UGV2-3   

Explore the universe of human proteins at neXtProt for NDRG3: NX_Q9UGV2

Explore proteomics data for NDRG3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UGV2

  • NDRG3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NDRG3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_071922.2  NP_114402.1  

    ENSEMBL proteins: 
     ENSP00000362909   ENSP00000352703   ENSP00000345292   ENSP00000416636   ENSP00000442813  
     ENSP00000362878  

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    Cloud-Clone Corp. Proteins for NDRG3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11936845

    NDRG3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR004142 Ndr

    Graphical View of Domain Structure for InterPro Entry Q9UGV2

    ProtoNet protein and cluster: Q9UGV2

    1 Blocks protein domain: IPB004142 Ndr family

    UniProtKB/Swiss-Prot: NDRG3_HUMAN, Q9UGV2
    Similarity: Belongs to the NDRG family


    NDRG3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    NDRG3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ndrg3):
     mortality/aging 

    NDRG3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NDRG3 
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate NDRG3 (see all 42):
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    SwitchGear 3'UTR luciferase reporter plasmidNDRG3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NDRG3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Apoptosis and Autophagy
    Apoptosis and Autophagy
    2Angiogenesis
    Angiogenesis
    3PI3K / Akt Signaling
    PI3K / Akt Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for NDRG3
        Apoptosis and Autophagy
    Angiogenesis
    PI3K / Akt Signaling




    NDRG3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDRG3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/7 Interacting proteins for NDRG3 (Q9UGV23 ENSP000003452924) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJB4Q9UDY43I2D: score=1 
    GLRA3O753113I2D: score=1 
    MTHFSDQ2M2963I2D: score=1 
    PPIFP304053I2D: score=1 
    SPENQ96T583I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007283spermatogenesis NAS11406283
    GO:0030154cell differentiation NAS11406283
    GO:0030308negative regulation of cell growth NAS11406283

    NDRG3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NDRG3

    Search CenterWatch for drugs/clinical trials and news about NDRG3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NDRG3 gene (2 alternative transcripts): 
    NM_022477.3  NM_032013.3  

    Unigene Cluster for NDRG3:

    NDRG family member 3
    Hs.437338  [show with all ESTs]
    Unigene Representative Sequence: AK128068
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373803 ENST00000359675 ENST00000349004(uc002xfw.3 uc002xfx.3 uc010zvq.2 uc010zvr.2)
    ENST00000422536 ENST00000540765 ENST00000373773
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate NDRG3 (see all 42):
    hsa-miR-194* hsa-miR-21* hsa-miR-4291 hsa-miR-140-5p hsa-miR-3607-3p hsa-miR-765 hsa-miR-759 hsa-miR-298
    SwitchGear 3'UTR luciferase reporter plasmidNDRG3 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NDRG3

    Additional mRNA sequence: 

    AB044943.1 AF308609.1 AK023618.1 AK027665.1 AK128068.1 AK295420.1 AK295466.1 BC136489.1 
    BC144169.1 NR_038370.1 

    10 DOTS entries:

    DT.95086156  DT.92475313  DT.101980321  DT.92475441  DT.100647967  DT.100794465  DT.100794474  DT.97847328 
    DT.120833203  DT.97847330 

    24/197 AceView cDNA sequences (see all 197):

    BF436896 T33084 BX951987 BU726185 BE086660 AA323106 BU177085 BQ009388 
    AU132685 AI637519 BM693284 AA322542 BM791796 AI435981 AU138025 BF436894 
    BM988498 CA420077 AK023618 T33098 AK128068 BQ640166 NM_032013 AI659189 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDRG3 expression in normal human tissues (normalized intensities)      NDRG3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTACTGTTA
    NDRG3 Expression
    About this image


    NDRG3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Lower Urinary Tract (Urinary System)
             visceral organ/urogenital sinus/nerves of urogenital sinus   

    See NDRG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDRG3

    SOURCE GeneReport for Unigene cluster: Hs.437338

    UniProtKB/Swiss-Prot: NDRG3_HUMAN, Q9UGV2
    Tissue specificity: Ubiquitous. Highly expressed in brain

        SABiosciences Expression via Pathway-Focused PCR Array including NDRG3: 
              Prostate Cancer in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NDRG3 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndrg31 , 5 N-myc downstream regulated gene 31, 5 89.96(n)1
    96(a)1
      2 (77.89 cM)5
    298121  NM_013865.21  NP_038893.11 
     1569273455 
    chicken
    (Gallus gallus)
    Aves NDRG36
    NDRG family member 3
    81(a)
    1 ↔ 1
    20(835504-867279)
    lizard
    (Anolis carolinensis)
    Reptilia NDRG36
    Uncharacterized protein
    83(a)
    1 ↔ 1
    4(134696351-134730964)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.176642 Xenopus laevis transcribed sequence with moderate similarity more 76.82(n)    CA794198.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044139.12   -- 75.57(n)   327395  BC044139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MESK21 Misexpression suppressor of KSR 2 51.17(n)
    43.16(a)
      37451  NM_206191.1  NP_995913.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G10A.31 Protein Y48G10A.3 47.59(n)
    34.54(a)
      173217  NM_060968.3  NP_493369.1 


    ENSEMBL Gene Tree for NDRG3 (if available)
    TreeFam Gene Tree for NDRG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDRG3 gene
    NDRG42  NDRG22  NDRG12  
    4 SIMAP similar genes for NDRG3 using alignment to 6 protein entries:     NDRG3_HUMAN (see all proteins):
    NDRG1    TRG14    NDRG4    NDRG2

    NDRG3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1838 SNPs in NDRG3 are shown (see all 1838)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390576511,2
    --35279703(+) GCACTC/TGGTCT 3 -- int10--------
    rs1415703351,2
    --35279726(+) GATGGA/GTACAA 3 -- int10--------
    rs60285731,2
    C,H--35279827(+) ACACAG/AGTGGT 3 -- int14Minor allele frequency- A:0.00NS EA 398
    rs1875431811,2
    --35279844(+) GTGACA/GTGGAC 3 -- int10--------
    rs1154712601,2
    F--35279856(+) ACCTTC/ATCAAG 3 -- int11Minor allele frequency- A:0.01WA 118
    rs61016401,2
    F,H--35279894(+) ACAACA/GCTGTC 3 -- int14Minor allele frequency- G:0.01NS EA 416
    rs1470314431,2
    --35280079(+) AATCAC/TATGTG 3 -- int10--------
    rs1170107291,2
    C,F--35280118(+) CAACTC/TGGTCC 3 -- int11Minor allele frequency- T:0.04NA 120
    rs790198851,2
    C,F--35280156(+) AAGAAA/GTAACA 3 -- int11Minor allele frequency- G:0.03NA 120
    rs1481241711,2
    --35280226(+) TACTCC/TGGCAG 3 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for NDRG3 (35280169 - 35374541 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for NDRG3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2722379CNV Deletion23290073
    esv2722380CNV Deletion23290073
    esv2722377CNV Deletion23290073
    esv2722378CNV Deletion23290073
    esv992784CNV Insertion20482838
    nsv833967CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605273    OMIM disorders: --

    8 diseases for NDRG3:    About MalaCards
    motor peripheral neuropathy    peripheral neuropathy    neuropathy    hepatitis b
    hepatocellular carcinoma    prostate cancer    prostatitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for NDRG3:
    Motor peripheral neuropathy

    NDRG3 for disorders           About GeneDecksing


    Export disorders for NDRG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDRG3 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with NDRG3)
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    1. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PubMed id 11936845)1, 2, 9 Qu X.... He F. (2002)
    2. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PubMed id 11352569)1, 2, 9 Zhou R.-H.... Miyata T. (2001)
    3. Differential expression patterns of NDRG family prote ins in the central nervous system. (PubMed id 17998568)1, 3 Okuda T....Miyata T. (2008)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. (PubMed id 10831399)1, 3 Kalaydjieva L.... Thomas P.K. (2000)
    7. Cloning and expression pattern of the human NDRG3 gene. (PubMed id 11406283)1, 9 Zhao W....Mao Y. (2001)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. miR-122 inhibits viral replication and cell proliferat ion in hepatitis B virus-related hepatocellular carcinoma and targets NDRG3. (PubMed id 21725618)1 Fan C.G....Liu Y.G. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57446 HGNC: 14462 AceView: NDRG3 Ensembl:ENSG00000101079 euGenes: HUgn57446
    ECgene: NDRG3 H-InvDB: NDRG3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDRG3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NDRG3 gene:
    Search GeneIP for patents involving NDRG3

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