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Aliases for NDRG2 Gene

Aliases for NDRG2 Gene

  • NDRG Family Member 2 2 3 5
  • N-Myc Downstream-Regulated Gene 2 Protein 3 4
  • SYLD 3 4
  • N-Myc Downstream Regulator 2 3
  • NDR1-Related Protein NDR2 3
  • Cytoplasmic Protein Ndr1 3
  • Syld709613 Protein 3
  • Protein Syld709613 4
  • Protein NDRG2 3
  • KIAA1248 4

External Ids for NDRG2 Gene

Previous GeneCards Identifiers for NDRG2 Gene

  • GC14M018857
  • GC14M015272
  • GC14M019476
  • GC14M019477
  • GC14M019478
  • GC14M020554
  • GC14M021484
  • GC14M001606

Summaries for NDRG2 Gene

Entrez Gene Summary for NDRG2 Gene

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for NDRG2 Gene

NDRG2 (NDRG Family Member 2) is a Protein Coding gene. Diseases associated with NDRG2 include Glioblastoma and Charcot-Marie-Tooth Disease, Type 4D. Among its related pathways are Validated targets of C-MYC transcriptional repression and Apoptosis and Autophagy. An important paralog of this gene is NDRG4.

UniProtKB/Swiss-Prot for NDRG2 Gene

  • Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Gene Wiki entry for NDRG2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG2 Gene

Genomics for NDRG2 Gene

Regulatory Elements for NDRG2 Gene

Enhancers for NDRG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G021014 1.2 Ensembl ENCODE 11.2 +55.6 55565 1.6 ELF3 PKNOX1 ARID4B THRB RAD21 RFX5 ZNF143 U2AF2 MIXL1 DEK RNASE7 ARHGEF40 NDRG2 ZNF219 METTL17 TMEM253 GC14M021020 GC14P021076
GH14G021043 1.1 ENCODE 11.5 +26.7 26697 2.0 FOXA2 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 METTL3 PARP2 CHD8 SUPT16H TMEM55B ARHGEF40 NDRG2 APEX1 ZNF219 TMEM253
GH14G020679 1.9 FANTOM5 ENCODE dbSUPER 1.4 +386.3 386340 9.8 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 CHD8 SUPT16H ENSG00000258515 METTL3 TTC5 ENSG00000258768 PARP2 TMEM55B RNASE4 RAB2B
GH14G021134 0.2 ENCODE 11.1 -63.3 -63265 0.2 ZNF219 NDRG2 ARHGEF40 TMEM253 LOC105378175 RNU6-252P
GH14G021068 1.6 FANTOM5 ENCODE dbSUPER 0.7 -0.2 -173 5.0 HDGF ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF143 FOS PAF1 ZNF263 ARHGEF40 SUPT16H METTL3 SALL2 TMEM253 ZNF219 RNASE7 TPPP2 ENSG00000255472 RNASE13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NDRG2 on UCSC Golden Path with GeneCards custom track

Promoters for NDRG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066448 72 2401 HDGF ARID4B SIN3A DMAP1 ZBTB7B ZNF143 ZNF263 SP3 SP5 ZHX2

Genomic Location for NDRG2 Gene

Chromosome:
14
Start:
21,016,763 bp from pter
End:
21,070,872 bp from pter
Size:
54,110 bases
Orientation:
Minus strand

Genomic View for NDRG2 Gene

Genes around NDRG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG2 Gene

Proteins for NDRG2 Gene

  • Protein details for NDRG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN36-NDRG2_HUMAN
    Recommended name:
    Protein NDRG2
    Protein Accession:
    Q9UN36
    Secondary Accessions:
    • B3KUE3
    • B4DE86
    • B7WP11
    • B7WPD5
    • D3DS07
    • D3DS10
    • Q567T1
    • Q68DW2
    • Q86U08
    • Q86U46
    • Q96FD3
    • Q96FT0
    • Q96JU0
    • Q96PN0
    • Q9BQH5
    • Q9ULH2

    Protein attributes for NDRG2 Gene

    Size:
    371 amino acids
    Molecular mass:
    40798 Da
    Quaternary structure:
    • Interacts with CTNNB1.
    SequenceCaution:
    • Sequence=BAA86562.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62350.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NDRG2 Gene

    Alternative splice isoforms for NDRG2 Gene

neXtProt entry for NDRG2 Gene

Post-translational modifications for NDRG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NDRG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NDRG2 (NDRG2)

No data available for DME Specific Peptides for NDRG2 Gene

Domains & Families for NDRG2 Gene

Protein Domains for NDRG2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NDRG2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UN36

UniProtKB/Swiss-Prot:

NDRG2_HUMAN :
  • Belongs to the NDRG family.
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG2: view

No data available for Gene Families for NDRG2 Gene

Function for NDRG2 Gene

Molecular function for NDRG2 Gene

UniProtKB/Swiss-Prot Function:
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.

Gene Ontology (GO) - Molecular Function for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21217774
genes like me logo Genes that share ontologies with NDRG2: view
genes like me logo Genes that share phenotypes with NDRG2: view

Animal Models for NDRG2 Gene

MGI Knock Outs for NDRG2:

Animal Model Products

CRISPR Products

miRNA for NDRG2 Gene

miRTarBase miRNAs that target NDRG2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NDRG2 Gene

Localization for NDRG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDRG2 Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NDRG2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 4
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005829 cytosol NAS 11936845
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NDRG2: view

Pathways & Interactions for NDRG2 Gene

genes like me logo Genes that share pathways with NDRG2: view

Pathways by source for NDRG2 Gene

3 Cell Signaling Technology pathways for NDRG2 Gene
1 BioSystems pathway for NDRG2 Gene

SIGNOR curated interactions for NDRG2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NDRG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IEA --
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0010574 regulation of vascular endothelial growth factor production IEA --
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with NDRG2: view

Drugs & Compounds for NDRG2 Gene

No Compound Related Data Available

Transcripts for NDRG2 Gene

Unigene Clusters for NDRG2 Gene

NDRG family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^
SP1: - - - - - - - - - - - - -
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ExUns: 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13a · 13b · 13c ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - - - - - -
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SP37:
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SP42: - - -
SP43: -
SP44:
SP45:

ExUns: 13d · 13e ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
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SP40: -
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SP45:

Relevant External Links for NDRG2 Gene

GeneLoc Exon Structure for
NDRG2
ECgene alternative splicing isoforms for
NDRG2

Expression for NDRG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NDRG2 Gene

Protein differential expression in normal tissues from HIPED for NDRG2 Gene

This gene is overexpressed in Salivary gland (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDRG2 Gene



Protein tissue co-expression partners for NDRG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDRG2 Gene:

NDRG2

SOURCE GeneReport for Unigene cluster for NDRG2 Gene:

Hs.525205

mRNA Expression by UniProt/SwissProt for NDRG2 Gene:

Q9UN36-NDRG2_HUMAN
Tissue specificity: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level).

Evidence on tissue expression from TISSUES for NDRG2 Gene

  • Nervous system(5)
  • Liver(4.8)
  • Intestine(4.7)
  • Kidney(4.3)
  • Muscle(4.3)
  • Heart(4.2)
  • Spleen(3.1)
  • Lung(2.9)
  • Adrenal gland(2.3)
  • Eye(2.2)
  • Lymph node(2.2)
  • Thyroid gland(2.2)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with NDRG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NDRG2 Gene

Orthologs for NDRG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NDRG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDRG2 34 35
  • 99.16 (n)
cow
(Bos Taurus)
Mammalia NDRG2 34 35
  • 92.34 (n)
dog
(Canis familiaris)
Mammalia NDRG2 34 35
  • 91.73 (n)
mouse
(Mus musculus)
Mammalia Ndrg2 34 16 35
  • 90.66 (n)
rat
(Rattus norvegicus)
Mammalia Ndrg2 34
  • 90.66 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NDRG2 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NDRG2 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDRG2 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg2 34
  • 70.19 (n)
Str.6843 34
African clawed frog
(Xenopus laevis)
Amphibia ndrg2-prov 34
zebrafish
(Danio rerio)
Actinopterygii ndrg2 34 35
  • 68.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta MESK2 36 35
  • 38 (a)
BcDNA:GH02439 36
  • 29 (a)
CG2082 35
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 36 35
  • 30 (a)
ZK1073.1 35
  • 23 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons NDL2 34
  • 45.88 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 35
  • 35 (a)
OneToMany
Species where no ortholog for NDRG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG2 Gene

ENSEMBL:
Gene Tree for NDRG2 (if available)
TreeFam:
Gene Tree for NDRG2 (if available)

Paralogs for NDRG2 Gene

Variants for NDRG2 Gene

Sequence variations from dbSNP and Humsavar for NDRG2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000119394 -- 21,032,810(+) CAACA(A/G)AGTCA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1000132361 -- 21,036,977(+) CAACC(A/G)CATTG intron-variant
rs1000324285 -- 21,066,019(+) ACTTG(C/T)ACCTG intron-variant
rs1000438847 -- 21,065,775(+) AGCAT(A/C)TTTAG intron-variant
rs1000546604 -- 21,046,177(+) GTTCT(A/G)TACTA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NDRG2 Gene

Variant ID Type Subtype PubMed ID
dgv1053n106 CNV deletion 24896259
esv1010817 CNV deletion 20482838
esv1716472 CNV deletion 17803354
esv2748449 CNV deletion 23290073
esv3246941 CNV deletion 24192839
esv3551208 CNV deletion 23714750
esv4248 CNV loss 18987735
esv9575 CNV loss 19470904
nsv1039369 CNV loss 25217958
nsv1070210 CNV deletion 25765185
nsv1153428 CNV deletion 26484159
nsv428293 CNV gain+loss 18775914
nsv826882 CNV gain 20364138
nsv832740 CNV gain 17160897
nsv84528 CNV deletion 16902084
nsv957516 CNV deletion 24416366

Variation tolerance for NDRG2 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDRG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDRG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG2 Gene

Disorders for NDRG2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NDRG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
charcot-marie-tooth disease, type 4d
  • charcot-marie-tooth disease type 4d
- elite association - COSMIC cancer census association via MalaCards
Search NDRG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NDRG2

Genetic Association Database (GAD)
NDRG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDRG2
genes like me logo Genes that share disorders with NDRG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NDRG2 Gene

Publications for NDRG2 Gene

  1. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. (PMID: 12845671) Deng Y. … Lin M.C.-M. (Int. J. Cancer 2003) 3 4 22 64
  2. Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. (PMID: 14572661) Choi S.-C. … Lim J.-S. (FEBS Lett. 2003) 3 4 22 64
  3. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PMID: 11936845) Qu X. … He F. (Mol. Cell. Biochem. 2002) 3 4 22 64
  4. Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. (PMID: 21247902) Hwang J. … Kim M.H. (J. Biol. Chem. 2011) 3 4 64
  5. NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. (PMID: 20045673) Furuta H. … Morishita K. (Biochem. Biophys. Res. Commun. 2010) 3 22 64

Products for NDRG2 Gene

Sources for NDRG2 Gene