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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDRG2 Gene

protein-coding   GIFtS: 57
GCID: GC14M021484

NDRG family member 2
 Explore 33 diseases affiliated with
NDRG2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NDRG2    

Aliases
for NDRG2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NDRG Family Member 21 2     N-Myc Downstream Regulator 22
SYLD1 2 3     NDR1-Related Protein NDR22
KIAA12481 3     Protein NDRG22
N-Myc Downstream-Regulated Gene 2 Protein2 3     Syld709613 Protein2
Cytoplasmic Protein Ndr12     Protein Syld7096133

External Ids:    HGNC: 144601   Entrez Gene: 574472   Ensembl: ENSG000001657957   OMIM: 6052725   UniProtKB: Q9UN363   

Export aliases for NDRG2 gene to outside databases

Previous GC identifers: GC14M018857 GC14M015272 GC14M019476 GC14M019477 GC14M019478 GC14M020554 GC14M001606


Summaries
for NDRG2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NDRG2:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The
protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be
involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been
described, but the full-length nature of some of these variants has not been determined. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: NDRG2_HUMAN, Q9UN36
Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional
activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell
and neuron differentiation

Gene Wiki entry for NDRG2


Genomic Views
for NDRG2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDRG2 gene promoter:
         TBP   CREB   deltaCREB   ARP-1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NDRG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDRG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDRG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

NDRG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDRG2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021484:  view genomic region     (about GC identifiers)

Start:
 21,484,922 bp from pter      End:
 21,539,031 bp from pter
Size:
 54,110 bases      Orientation:
 minus strand

Proteins
for NDRG2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NDRG2_HUMAN, Q9UN36 (See protein sequence)
Recommended Name: Protein NDRG2  
Size: 371 amino acids; 40798 Da
Subunit: Interacts with CTNNB1
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone (By similarity). Note=In
neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity)
Developmental stage: Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in
fetal brain and increases during brain postnatal development
Caution: Has some similarity to hydrolases, but lacks the conserved Ser-His-Asp catalytic triad. Has no hydrolase
activity towards p-nitrophenylbutyrate (in vitro)
Sequence caution: Sequence=BAA86562.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAD62350.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for NDRG2:
2XMQ (3D)        2XMR (3D)        2XMS (3D)    
Secondary accessions: B3KUE3 B7WP11 B7WPD5 D3DS07 D3DS10 Q567T1 Q68DW2 Q86U08 Q86U46 Q96FD3 Q96FT0
Q96JU0 Q96PN0 Q9BQH5 Q9ULH2
Alternative splicing: 5 isoforms:  Q9UN36-1   Q9UN36-2   Q9UN36-3   Q9UN36-4   Q9UN36-5   

Explore the universe of human proteins at neXtProt for NDRG2: NX_Q9UN36

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UN36

    • NDRG2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (8 alternative transcripts): 
    NP_057334.1  NP_963293.1  NP_963294.1  NP_963831.1  NP_963832.1  NP_963833.1  NP_963834.1  NP_963835.1  

    ENSEMBL proteins: 
     ENSP00000298687   ENSP00000344620   ENSP00000451341   ENSP00000450835   ENSP00000452216  
     ENSP00000452038   ENSP00000452306   ENSP00000380951   ENSP00000353649   ENSP00000452047  
     ENSP00000451712   ENSP00000450446   ENSP00000452006   ENSP00000380949   ENSP00000380945  
     ENSP00000298684   ENSP00000380943   ENSP00000385889   ENSP00000452117   ENSP00000451966  
     ENSP00000452413   ENSP00000452362   ENSP00000451274   ENSP00000450691   ENSP00000397250  
     ENSP00000452334   ENSP00000451353   ENSP00000451105   ENSP00000450545   ENSP00000452482  
     ENSP00000451094   ENSP00000452278   ENSP00000450493   ENSP00000451951   ENSP00000451059  
     ENSP00000452592   ENSP00000450513   ENSP00000452053   ENSP00000451302   ENSP00000451471  
     ENSP00000452548   ENSP00000450504   ENSP00000452262   ENSP00000450929   ENSP00000451185  
     ENSP00000451348   ENSP00000451472   ENSP00000452247   ENSP00000451414   ENSP00000452344  
     ENSP00000450852   ENSP00000451981   ENSP00000451163   ENSP00000452179   ENSP00000451541  
     ENSP00000452302   ENSP00000450825   ENSP00000450450   ENSP00000452458   ENSP00000452274  
     ENSP00000380956   ENSP00000380954   ENSP00000380953  

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    Novus Biologicals NDRG2 Proteins
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    ProSpec Recombinant Protein for NDRG2
    Uscn Proteins for NDRG2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005813centrosome IDA--


    NDRG2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NDRG2

    Protein Domains /
    Families
    for NDRG2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NDRG2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004142 Ndr

    Graphical View of Domain Structure for InterPro Entry Q9UN36

    ProtoNet protein and cluster: Q9UN36

    1 Blocks protein family: IPB004142 Ndr family

    UniProtKB/Swiss-Prot: NDRG2_HUMAN, Q9UN36
    Similarity: Belongs to the NDRG family


    Function
    for NDRG2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NDRG2_HUMAN, Q9UN36
    Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional
    activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell
    and neuron differentiation

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: NDRG2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--


    NDRG2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for NDRG2:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Ndrg2tm1.1Xzg for NDRG2
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ndrg2):
     embryogenesis  skeleton 

    NDRG2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NDRG2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    2Angiogenesis
    		Angiogenesis1.00
    3Validated targets of C-MYC transcriptional repression
    		Validated targets of C-MYC transcriptional repression1.00
    4PI3K / Akt Signaling
    		PI3K / Akt Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for NDRG2
        Apoptosis and Autophagy
    Angiogenesis
    PI3K / Akt Signaling

    1 BioSystems Pathway for NDRG2 
        Validated targets of C-MYC transcriptional repression



    NDRG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NDRG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/12 Interacting proteins for NDRG2 (Q9UN361, 2, 3 ENSP000002986874) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RABAC1Q9UI142MINT-8394598 MINT-8394757 MINT-8394622 MINT-8394778 MINT-8394562 MINT-8394741 MINT-8396094 MINT-8394575
    CTDP1Q9Y5B03, ENSP000002995434I2D: score=2 STRING: ENSP00000299543
    ATP1B1P050263, ENSP000003567894I2D: score=1 STRING: ENSP00000356789
    ESR1P033721, ENSP000002062494EBI-3895741,EBI-78473 STRING: ENSP00000206249
    HAX1O001653I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001818negative regulation of cytokine production IEA--
    GO:0007165signal transduction ----
    GO:0007399nervous system development IEA--
    GO:0010574regulation of vascular endothelial growth factor production IEA--
    GO:0016055Wnt receptor signaling pathway IEA--


    NDRG2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NDRG2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NDRG2
    Search CenterWatch for drugs/clinical trials and news about NDRG2 

    Transcripts
    for NDRG2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NDRG2 gene (8 alternative transcripts): 
    NM_016250.2  NM_201535.1  NM_201536.1  NM_201537.1  NM_201538.1  NM_201539.1  NM_201540.1  NM_201541.1  

    Unigene Cluster for NDRG2:

    NDRG family member 2
    Hs.525205  [show with all ESTs]
    Unigene Representative Sequence: AK096999
    18/80 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 80):
    ENST00000298687(uc001vyu.3 uc001vze.3 uc001vzd.3 uc001vzg.3 uc010aig.3 uc010tll.2)
    ENST00000350792(uc001vzf.3) ENST00000554770 ENST00000556716 ENST00000557633
    ENST00000554104(uc001vyt.3) ENST00000555158(uc001vyv.3) ENST00000553503(uc001vyw.3)
    ENST00000397853(uc001vyy.3 uc001vza.3) ENST00000360463 ENST00000556612
    ENST00000556147 ENST00000557353 ENST00000554143(uc001vzb.3 uc001vyz.3)
    ENST00000397851(uc001vyx.3) ENST00000397847 ENST00000298684 ENST00000555650


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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB033074.1 AF159092.3 AF304051.1 AK024521.1 AK057843.1 AK057847.1 AK090657.1 AK096999.1 
    AK130029.1 AK293514.1 AL136574.1 BC010458.1 BC011240.1 BC013209.1 BC093038.1 BX247987.1 
    BX248031.1 BX647091.1 BX647748.1 CR749252.1 

    24/90 DOTS entries (see all 90):

    DT.102843109  DT.102843110  DT.92440580  DT.97784527  DT.120755903  DT.100892450  DT.100892415  DT.95275617 
    DT.120755999  DT.120755962  DT.92440592  DT.120755928  DT.453301  DT.120755887  DT.100659137  DT.100892427 
    DT.120755995  DT.100892438  DT.100892433  DT.120756019  DT.120755912  DT.91653263  DT.101985529  DT.100892448 

    24/724 AceView cDNA sequences (see all 724):

    NM_201540 BU146482 BM766206 CR603144 CD722591 CR620953 BQ893123 CR597040 
    F26519 CB135779 BP342735 N78113 CR607901 CB265573 T33463 CK430606 
    CB153431 CB139135 M78975 F28516 CB146615 CB148857 BI517902 CB153013 

    GeneLoc Exon Structure

    5/45 Alternative Splicing Database (ASD) splice patterns (SP) for NDRG2 (see all 45)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^
    SP1:                                                        -     -     -     -     -     -     -     -     -                       -     -     -     -         
    SP2:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -     -     -     -         
    SP3:                                                        -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -         
    SP4:                                                                                -     -     -     -     -                       -     -     -     -         
    SP5:                                                                                                                                -     -     -     -         

    ExUns: 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13a · 13b · 13c ·
    SP1:                    -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   
    SP2:  -     -     -     -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   
    SP3:                    -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   
    SP4:  -     -     -     -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   
    SP5:                    -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   

    ExUns: 13d · 13e ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
    SP1:  -     -                             -     -     -                             -     -                                       
    SP2:  -     -                             -     -     -                             -     -                                       
    SP3:  -     -                             -     -     -                             -     -                                       
    SP4:  -     -                             -     -     -                             -     -                                       
    SP5:  -     -                             -     -     -                             -     -                                       


    ECgene alternative splicing isoforms for NDRG2

    Expression
    for NDRG2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDRG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CGGGGAGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NDRG2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusBrain
    BrainMedulla OblongataBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose

    See NDRG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDRG2

    SOURCE GeneReport for Unigene cluster: Hs.525205

    UniProtKB/Swiss-Prot: NDRG2_HUMAN, Q9UN36
    Tissue specificity: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney and
    liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic and liver
    cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in glioblastoma.
    Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at protein level)

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    Orthologs
    for NDRG2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NDRG2 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia NDRG26
    		 --
    		 81(a)
    		 1 ↔ 1
    		 GL343253.1(1709549-1741580)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ndrg2-prov2 NDRG family member 2 76.3(n)    BC043915.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ndrg21 N-myc downstream regulated gene 2 67.71(n)
    68.75(a)    		   494050  NM_001008593.1  NP_001008593.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MESK23   -- 38(a)
    (best of 2)    		   57E8   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y48G10A.33   -- 30(a)   I(13479864-13482231)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NDL31 N-MYC downregulated-like 3 protein 45.6(n)
    33.46(a)    		   816481  NM_127520.3  NP_179552.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g01926001 hypothetical protein 46.17(n)
    33.57(a)    		   4327306  NM_001048813.1  NP_001042278.1 


    ENSEMBL Gene Tree for NDRG2 (if available)
    TreeFam Gene Tree for NDRG2 (if available) 

    Paralogs
    for NDRG2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDRG2 gene
    NDRG42  NDRG32  NDRG12  
    4 SIMAP similar genes for NDRG2 using alignment to 46 protein entries:     NDRG2_HUMAN (see all proteins):
    TRG14    NDRG3    NDRG1    NDRG4

    NDRG2 for paralogs           About GeneDecksing



    Genomic Variants
    for NDRG2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/245 NCBI SNPs in NDRG2 are shown (see all 245)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1458887921,2
    		--21484425(+) GCCTCC/TCTAGT 8 -- ds50010--------
    rs1384660671,2
    		--21484671(+) AGTTAC/GCCATA 8 -- ds50010--------
    rs1425660191,2
    		--21484761(+) TTGTAC/TTGGAA 8 -- ds50010--------
    rs1908063431,2
    		--21484842(+) ATCACC/TTTGAG 8 -- ds50010--------
    rs1122304311,2
    		C--21484930(+) CGGTAC/G/TTCAGA 16 -- ut311CSA 1
    rs1469036731,2
    		--21484963(+) AGCAGA/CAGTTG 8 -- ut310--------
    rs572834221,2
    		C,F,--21484977(+) GAGACG/AGGAGG 8 -- ut315Minor allele frequency- A:0.22WA CSA EA 244
    rs1389723031,2
    		--21484999(+) ACATAA/CTACAG 8 -- ut310--------
    rs1812113581,2
    		--21485193(+) TGCCCA/GCCAAC 8 -- ut310--------
    rs1170847281,2
    		F,--21485210(+) TCCAAC/ATTCCT 8 -- ut311Minor allele frequency- A:0.04EA 120

    HapMap Linkage Disequilibrium report for NDRG2 (21484922 - 21539031 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NDRG2: --

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    Disorders / Diseases
    for NDRG2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NDRG2 for disorders           About GeneDecksing

    OMIM gene information: 605272    OMIM disorders: --

    20/33 diseases for NDRG2 (see all 33):    About MalaCards
    glioblastoma    motor peripheral neuropathy    clear cell renal cell carcinoma    gastrointestinal stromal tumor
    renal cell carcinoma    peripheral neuropathy    intrahepatic cholangiocarcinoma    wilms tumor
    neuropathy    cholangiocarcinoma    noma    liver cancer
    colon carcinoma    hepatocellular carcinoma    cervical cancer    alzheimer's disease
    cervicitis    colon cancer    thyroid cancer    carcinoma

    1 Novoseek disease relationship for NDRG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 33.1 46 19336468 (3), 18709645 (2), 19067970 (2), 18591767 (2) (see all 13)


    Export disorders for NDRG2 gene to outside databases

    Publications
    for NDRG2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDRG2 gene, integrated from 9 sources (see all 81):
    (articles sorted by number of sources associating them with NDRG2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. (PubMed id 14572661)1, 2, 9 Choi S.-C.... Lim J.-S. (2003)
    2. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PubMed id 11936845)1, 2, 9 Qu X.... He F. (2002)
    3. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. (PubMed id 12845671)1, 2, 9 Deng Y....Lin M.C.-M. (2003)
    4. Crystal Structure of the Human N-Myc Downstream-regulated Gene 2 Protein Provides Insight into Its Role as a Tumor Suppressor. (PubMed id 21247902)1, 2 Hwang J.... Kim M.H. (2011)
    5. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. (PubMed id 16103061)1, 2 Lusis E.A.... Perry A. (2005)
    6. NDRG2: a novel Alzheimer's disease associated protein. (PubMed id 15207261)1, 2 Mitchelmore C.... Jensen N.A. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. NDRG2 expression and mutation in human liver and pancreatic cancers. (PubMed id 15526377)1, 2 Hu X.-L.... Yao L.-B. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PubMed id 11352569)1, 2 Zhou R.-H.... Miyata T. (2001)

    External Searches for NDRG2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NDRG2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57447 HGNC: 14460 AceView: NDRG2 Ensembl:ENSG00000165795 euGenes: HUgn57447
    ECgene: NDRG2 H-InvDB: NDRG2

    Other Databases showing NDRG2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1248

    Specialized Databases showing NDRG2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDRG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NDRG2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NDRG2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NDRG2 gene:
    Search GeneIP for patents involving NDRG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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