Aliases for NDRG2 Gene
External Ids for NDRG2 Gene
Previous GeneCards Identifiers for NDRG2 Gene
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for NDRG2 Gene
NDRG2 (NDRG Family Member 2) is a Protein Coding gene. Diseases associated with NDRG2 include transitional papilloma and glioblastoma. Among its related pathways are Angiogenesis (CST) and Apoptosis and Autophagy. An important paralog of this gene is NDRG1.
UniProtKB/Swiss-Prot for NDRG2 Gene
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.