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NDRG2 Gene

protein-coding   GIFtS: 62
GCID: GC14M021484

NDRG Family Member 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NDRG Family Member 21 2     NDR1-Related Protein NDR22
SYLD2 3     Protein NDRG22
N-Myc Downstream-Regulated Gene 2 Protein2 3     Syld709613 Protein2
Cytoplasmic Protein Ndr12     KIAA12483
N-Myc Downstream Regulator 22     Protein Syld7096133

External Ids:    HGNC: 144601   Entrez Gene: 574472   Ensembl: ENSG000001657957   OMIM: 6052725   UniProtKB: Q9UN363   

Export aliases for NDRG2 gene to outside databases

Previous GC identifers: GC14M018857 GC14M015272 GC14M019476 GC14M019477 GC14M019478 GC14M020554 GC14M001606


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDRG2 Gene:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase
superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth.
This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of
this gene have been described, but the full-length nature of some of these variants has not been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for NDRG2 Gene:
NDRG2 (NDRG family member 2) is a protein-coding gene. An important paralog of this gene is NDRG4.

UniProtKB/Swiss-Prot: NDRG2_HUMAN, Q9UN36
Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated
transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be
involved in dendritic cell and neuron differentiation

Gene Wiki entry for NDRG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDRG2 gene promoter:
         TBP   CREB   deltaCREB   ARP-1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NDRG2 promoter sequence
   Search Chromatin IP Primers for NDRG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDRG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

NDRG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDRG2 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M021484:  view genomic region     (about GC identifiers)

Start:
21,484,922 bp from pter      End:
21,539,031 bp from pter
Size:
54,110 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NDRG2_HUMAN, Q9UN36 (See protein sequence)
Recommended Name: Protein NDRG2  
Size: 371 amino acids; 40798 Da
Subunit: Interacts with CTNNB1
Developmental stage: Specifically expressed during dendritic cell differentiation (in vitro). Expression is low in
fetal brain and increases during brain postnatal development
Caution: Has some similarity to hydrolases, but lacks the conserved Ser-His-Asp catalytic triad. Has no hydrolase
activity towards p-nitrophenylbutyrate (in vitro)
Sequence caution: Sequence=BAA86562.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAD62350.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for NDRG2:
2XMQ (3D)        2XMR (3D)        2XMS (3D)    
Secondary accessions: B3KUE3 B7WP11 B7WPD5 D3DS07 D3DS10 Q567T1 Q68DW2 Q86U08 Q86U46 Q96FD3
Q96FT0 Q96JU0 Q96PN0 Q9BQH5 Q9ULH2
Alternative splicing: 5 isoforms:  Q9UN36-1   Q9UN36-2   Q9UN36-3   Q9UN36-4   Q9UN36-5   

Explore the universe of human proteins at neXtProt for NDRG2: NX_Q9UN36

Explore proteomics data for NDRG2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NDRG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (14 alternative transcripts): 
    NP_001269140.1  NP_001269141.1  NP_001269142.1  NP_001269143.1  NP_001269144.1  NP_001269145.1  NP_057334.1  NP_963293.1  
    NP_963294.1  NP_963831.1  NP_963832.1  NP_963833.1  NP_963834.1  NP_963835.1  

    ENSEMBL proteins: 
     ENSP00000298687   ENSP00000344620   ENSP00000450835   ENSP00000452216   ENSP00000452038  
     ENSP00000452306   ENSP00000380951   ENSP00000353649   ENSP00000451712   ENSP00000450446  
     ENSP00000452006   ENSP00000380949   ENSP00000380945   ENSP00000298684   ENSP00000380943  
     ENSP00000385889   ENSP00000452117   ENSP00000451966   ENSP00000452413   ENSP00000452362  
     ENSP00000451274   ENSP00000450691   ENSP00000397250   ENSP00000452334   ENSP00000451353  
     ENSP00000451105   ENSP00000450545   ENSP00000452482   ENSP00000451094   ENSP00000452278  
     ENSP00000450493   ENSP00000451951   ENSP00000451059   ENSP00000452592   ENSP00000450513  
     ENSP00000452053   ENSP00000451302   ENSP00000451471   ENSP00000452548   ENSP00000450504  
     ENSP00000452262   ENSP00000450929   ENSP00000451185   ENSP00000451348   ENSP00000451472  
     ENSP00000452247   ENSP00000451414   ENSP00000452344   ENSP00000450852   ENSP00000451981  
     ENSP00000451163   ENSP00000452179   ENSP00000451541   ENSP00000452302   ENSP00000450825  
     ENSP00000450450   ENSP00000452458   ENSP00000452274   ENSP00000380956   ENSP00000380954  
     ENSP00000380953  

    NDRG2 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for NDRG2
    Cloud-Clone Corp. Proteins for NDRG2

     
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    antibodies-online proteins for NDRG2 (16 products) 

     
    antibodies-online peptides for NDRG2

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    antibodies-online antibodies for NDRG2 (58 products) 

    NDRG2 Assay Products:

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    antibodies-online kits for NDRG2 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004142 Ndr

    Graphical View of Domain Structure for InterPro Entry Q9UN36

    ProtoNet protein and cluster: Q9UN36

    1 Blocks protein domain: IPB004142 Ndr family

    UniProtKB/Swiss-Prot: NDRG2_HUMAN, Q9UN36
    Similarity: Belongs to the NDRG family


    Find genes that share domains with NDRG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDRG2_HUMAN, Q9UN36
    Function: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated
    transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be
    involved in dendritic cell and neuron differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with NDRG2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NDRG2:
     G0/1 arrest  Increased G1 DNA content 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ndrg2):
     embryogenesis  skeleton 

    Find genes that share phenotypes with NDRG2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ndrg2tm1.1Xzg for NDRG2

       genOway: Develop your customized and physiologically relevant rodent model for NDRG2

    miRNA
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    miRTarBase miRNAs that target NDRG2:
    hsa-mir-145-5p (MIRT021510)

    Block miRNA regulation of human, mouse, rat NDRG2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NDRG2 (see all 15):
    hsa-miR-301b hsa-miR-181c hsa-miR-139-5p hsa-miR-301a hsa-miR-181a hsa-miR-3666 hsa-miR-181d hsa-miR-454
    SwitchGear 3'UTR luciferase reporter plasmidNDRG2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NDRG2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 8): NDRG2 (NM_201537)
    Sino Biological Human cDNA Clone for NDRG2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDRG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDRG2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDRG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDRG2_HUMAN, Q9UN36: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone (By similarity).
    Note=In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    cytoskeleton4
    golgi apparatus4
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005813centrosome IDA--

    Find genes that share ontologies with NDRG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDRG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression
    2PI3K / Akt Signaling
    PI3K / Akt Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy
    4Angiogenesis (CST)
    Angiogenesis


    Find genes that share SuperPaths with NDRG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for NDRG2
        Apoptosis and Autophagy
    Angiogenesis
    PI3K / Akt Signaling

    1 BioSystems Pathway for NDRG2
        Validated targets of C-MYC transcriptional repression



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NDRG2
    Interactions:

        GeneGlobe Interaction Network for NDRG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for NDRG2 (Q9UN361, 2, 3 ENSP000002986874) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RABAC1Q9UI141, 2EBI-8084503,EBI-712367 MINT-8394757 MINT-8394598 MINT-8394778 MINT-8394622 MINT-8394562 MINT-8394741 MINT-8396094 MINT-8394575
    CTDP1Q9Y5B03, ENSP000002995434I2D: score=2 STRING: ENSP00000299543
    ATP1B1P050263, ENSP000003567894I2D: score=1 STRING: ENSP00000356789
    ESR1P033721, ENSP000002062494EBI-3895741,EBI-78473 STRING: ENSP00000206249
    HAX1O001653I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001818negative regulation of cytokine production IEA--
    GO:0007165signal transduction ----
    GO:0007399nervous system development ----
    GO:0010574regulation of vascular endothelial growth factor production IEA--
    GO:0016055Wnt signaling pathway IEA--

    Find genes that share ontologies with NDRG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDRG2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NDRG2 gene (14 alternative transcripts): 
    NM_001282211.1  NM_001282212.1  NM_001282213.1  NM_001282214.1  NM_001282215.1  NM_001282216.1  NM_016250.2  NM_201535.1  
    NM_201536.1  NM_201537.1  NM_201538.1  NM_201539.1  NM_201540.1  NM_201541.1  

    Unigene Cluster for NDRG2:

    NDRG family member 2
    Hs.525205  [show with all ESTs]
    Unigene Representative Sequence: AK096999
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 78):
    ENST00000298687(uc001vyu.3 uc001vze.3 uc001vzd.3 uc001vzg.3 uc010aig.3 uc010tll.2)
    ENST00000350792(uc001vzf.3) ENST00000556716 ENST00000557633 ENST00000554104(uc001vyt.3)
    ENST00000555158(uc001vyv.3) ENST00000553503(uc001vyw.3) ENST00000397853(uc001vyy.3 uc001vza.3)
    ENST00000360463 ENST00000556147 ENST00000557353 ENST00000554143(uc001vzb.3 uc001vyz.3)
    ENST00000397851(uc001vyx.3) ENST00000397847 ENST00000298684 ENST00000555650
    ENST00000397844(uc001vzc.3) ENST00000403829
    miRNA
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    hsa-miR-301b hsa-miR-181c hsa-miR-139-5p hsa-miR-301a hsa-miR-181a hsa-miR-3666 hsa-miR-181d hsa-miR-454
    SwitchGear 3'UTR luciferase reporter plasmidNDRG2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NDRG2
      QuantiFast Probe-based Assays in human, mouse, rat NDRG2

    Additional mRNA sequence: 

    AB033074.1 AF159092.3 AF304051.1 AK024521.1 AK057843.1 AK057847.1 AK090657.1 AK096999.1 
    AK130029.1 AK293514.1 AL136574.1 BC010458.1 BC011240.1 BC013209.1 BC093038.1 BX247987.1 
    BX248031.1 BX647091.1 BX647748.1 CR749252.1 

    Selected DOTS entries (see all 90):

    DT.102843109  DT.102843110  DT.92440580  DT.97784527  DT.120755903  DT.100892450  DT.100892415  DT.95275617 
    DT.120755999  DT.120755962  DT.92440592  DT.120755928  DT.453301  DT.120755887  DT.100659137  DT.100892427 
    DT.120755995  DT.100892438  DT.100892433  DT.120756019  DT.120755912  DT.91653263  DT.101985529  DT.100892448 

    Selected AceView cDNA sequences (see all 724):

    BF960321 CR601715 AI872630 BP346929 BP352630 NM_201539 AI474542 CD245743 
    BX248031 CD515320 AL546540 AI658930 BQ640652 Z42395 F25563 AI336011 
    CB138255 T08543 F27566 F29260 CF141086 CB270498 F28911 CR612684 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDRG2 (see all 45)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d · 4e · 4f ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^
    SP1:                                                        -     -     -     -     -     -     -     -     -                       -     -     -     -         
    SP2:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -     -     -     -         
    SP3:                                                        -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -         
    SP4:                                                                                -     -     -     -     -                       -     -     -     -         
    SP5:                                                                                                                                -     -     -     -         

    ExUns: 9a · 9b · 9c · 9d ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g · 11h ^ 12a · 12b · 12c · 12d · 12e · 12f · 12g · 12h ^ 13a · 13b · 13c ·
    SP1:                    -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   
    SP2:  -     -     -     -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   
    SP3:                    -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   
    SP4:  -     -     -     -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   
    SP5:                    -     -                 -     -     -                                   -                 -     -     -     -     -     -     -     -   

    ExUns: 13d · 13e ^ 14a · 14b ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b · 24c
    SP1:  -     -                             -     -     -                             -     -                                       
    SP2:  -     -                             -     -     -                             -     -                                       
    SP3:  -     -                             -     -     -                             -     -                                       
    SP4:  -     -                             -     -     -                             -     -                                       
    SP5:  -     -                             -     -     -                             -     -                                       


    ECgene alternative splicing isoforms for NDRG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    NDRG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGGAGATG
    NDRG2 Expression
    About this image


    NDRG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Mesencephalic Ventricular Zone
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Hindgut
    NDRG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDRG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525205

    UniProtKB/Swiss-Prot: NDRG2_HUMAN, Q9UN36
    Tissue specificity: Highly expressed in brain, heart, skeletal muscle and salivary gland, and moderately in kidney
    and liver. Expressed in dendritic cells, but not in other blood cells. Expression levels are low in pancreatic
    and liver cancer tissues; absent in meningioma. Expressed in low-grade gliomas but present at low levels in
    glioblastoma. Isoform 1 and isoform 2 are present in brain neurons and up-regulated in Alzheimer disease (at
    protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NDRG2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndrg21 , 5 N-myc downstream regulated gene 21, 5 90.66(n)1
    95.69(a)1
      14 (26.72 cM)5
    298111  NM_013864.21  NP_038892.11 
     519052715 
    lizard
    (Anolis carolinensis)
    Reptilia NDRG26
    NDRG family member 2
    69(a)
    1 ↔ 1
    GL343253.1(1707154-1752435)
    African clawed frog
    (Xenopus laevis)
    Amphibia ndrg2-prov2 NDRG family member 2 76.3(n)    BC043915.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndrg21 N-myc downstream regulated gene 2 68.49(n)
    70.14(a)
      494050  NM_001008593.1  NP_001008593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MESK23   -- 38(a)
    (best of 2)
      57E8   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G10A.33   -- 30(a)   I(13479864-13482231)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NDL21 NDL2 45.88(n)
    34.69(a)
      831051  NM_121217.2  NP_568251.1 


    ENSEMBL Gene Tree for NDRG2 (if available)
    TreeFam Gene Tree for NDRG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDRG2 gene
    NDRG42  NDRG32  NDRG12  
    4 SIMAP similar genes for NDRG2 using alignment to 44 protein entries:     NDRG2_HUMAN (see all proteins):
    TRG14    NDRG3    NDRG1    NDRG4

    Find genes that share paralogs with NDRG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NDRG2 (see all 352)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12434521,2
    C,F--1616283(+) AGGCTC/GGTTCT 4 -- int19Minor allele frequency- G:0.38NA WA EA 370
    rs12434531,2
    C,F,A--1616289(+) GTTCTA/CCCCTA 4 -- int110Minor allele frequency- C:0.38NA WA EA 372
    rs1449416111,2
    --1616311(+) TTCCAC/TGTCAG 4 -- int10--------
    rs1458887921,2
    --21484425(+) GCCTCC/TCTAGT 8 -- ds50010--------
    rs1384660671,2
    --21484671(+) AGTTAC/GCCATA 8 -- ds50010--------
    rs1425660191,2
    --21484761(+) TTGTAC/TTGGAA 8 -- ds50010--------
    rs1908063431,2
    --21484842(+) ATCACC/TTTGAG 8 -- ds50010--------
    rs1129660231,2
    C--21484929(+) ACGGTA/TCTCAG 8 -- ut310--------
    rs1122304311,2
    C--21484930(+) CGGTAC/G/TTCAGA 16 -- ut311CSA 1
    rs1469036731,2
    C--21484963(+) AGCAGA/CAGTTG 8 -- ut310--------

    HapMap Linkage Disequilibrium report for NDRG2 (21484922 - 21539031 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NDRG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832740CNV Gain17160897
    nsv428293CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NDRG2
    DNA2.0 Custom Variant and Variant Library Synthesis for NDRG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605272    OMIM disorders: --


    Find genes that share disorders with NDRG2           About GenesLikeMe

    1 Novoseek inferred disease relationship for NDRG2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 33.1 46 19336468 (3), 18709645 (2), 19067970 (2), 18591767 (2) (see all 13)

    Genetic Association Database (GAD): NDRG2

    Export disorders for NDRG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDRG2 gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with NDRG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. (PubMed id 14572661)1, 2, 9 Choi S.-C.... Lim J.-S. (FEBS Lett. 2003)
    2. Characterization and expression of three novel differentiation- related genes belong to the human NDRG gene family. (PubMed id 11936845)1, 2, 9 Qu X.... He F. (Mol. Cell. Biochem. 2002)
    3. N-Myc downstream-regulated gene 2 (NDRG2) inhibits glioblastoma cell proliferation. (PubMed id 12845671)1, 2, 9 Deng Y....Lin M.C.-M. (Int. J. Cancer 2003)
    4. Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. (PubMed id 21247902)1, 2 Hwang J.... Kim M.H. (J. Biol. Chem. 2011)
    5. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. (PubMed id 16103061)1, 2 Lusis E.A.... Perry A. (Cancer Res. 2005)
    6. NDRG2: a novel Alzheimer's disease associated protein. (PubMed id 15207261)1, 2 Mitchelmore C.... Jensen N.A. (Neurobiol. Dis. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. NDRG2 expression and mutation in human liver and pancreatic cancers. (PubMed id 15526377)1, 2 Hu X.-L.... Yao L.-B. (World J. Gastroenterol. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart. (PubMed id 11352569)1, 2 Zhou R.-H.... Miyata T. (Genomics 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57447 HGNC: 14460 AceView: NDRG2 Ensembl:ENSG00000165795 euGenes: HUgn57447
    ECgene: NDRG2 H-InvDB: NDRG2

    (According to HUGE)
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    HUGE: KIAA1248

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDRG2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NDRG2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDRG2 gene:
    Search GeneIP for patents involving NDRG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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