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Aliases for NDRG1 Gene

Aliases for NDRG1 Gene

  • N-Myc Downstream Regulated 1 2 3 5
  • Reducing Agents And Tunicamycin-Responsive Protein 3 4
  • N-Myc Downstream-Regulated Gene 1 Protein 3 4
  • Nickel-Specific Induction Protein Cap43 3 4
  • Differentiation-Related Gene 1 Protein 3 4
  • DRG-1 3 4
  • RIT42 3 4
  • CAP43 3 4
  • DRG1 3 4
  • Rtp 3 4
  • Protein Regulated By Oxygen-1 3
  • Protein NDRG1 3
  • PROXY1 3
  • CMT4D 3
  • HMSNL 3
  • TARG1 3
  • NDR1 3
  • NMSL 3
  • TDD5 3
  • GC4 3

External Ids for NDRG1 Gene

Previous HGNC Symbols for NDRG1 Gene

  • CAP43

Previous GeneCards Identifiers for NDRG1 Gene

  • GC08M132979
  • GC08M134336
  • GC08M133920
  • GC08M134206
  • GC08M134318
  • GC08M129569
  • GC08M134249

Summaries for NDRG1 Gene

Entrez Gene Summary for NDRG1 Gene

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for NDRG1 Gene

NDRG1 (N-Myc Downstream Regulated 1) is a Protein Coding gene. Diseases associated with NDRG1 include Charcot-Marie-Tooth Disease, Type 4D and Neuropathy, Congenital Hypomyelinating. Among its related pathways are TP53 Regulates Transcription of Cell Death Genes and Gene Expression. GO annotations related to this gene include microtubule binding and cadherin binding. An important paralog of this gene is NDRG3.

UniProtKB/Swiss-Prot for NDRG1 Gene

  • Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.

Gene Wiki entry for NDRG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG1 Gene

Genomics for NDRG1 Gene

Regulatory Elements for NDRG1 Gene

Enhancers for NDRG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F133242 1.4 FANTOM5 Ensembl ENCODE 15.2 +54.7 54694 9.2 HDGF YBX1 RAD21 YY1 ZNF366 ZNF207 RCOR1 PAF1 CEBPB ZNF592 NDRG1 PHF20L1 GC08M133232
GH08F133319 0.8 Ensembl ENCODE 12.4 -20.8 -20846 6.0 TBP CTCF GTF2F1 ATF1 ZMYM3 RAD21 RFX5 YY1 ZNF143 THAP11 WISP1 NDRG1 SLA RPL32P20
GH08F133327 0.5 ENCODE 12.3 -27.1 -27060 2.3 GATAD2A NFIA MNT REST RAD21 YY1 CEBPA CREB1 ZBTB33 ZMIZ1 NDRG1 RPL32P20 LOC105375772
GH08F133257 0.5 ENCODE 11.7 +41.4 41433 5.3 ATF3 RAD21 MAFK ATF2 NR2F2 NDRG1 ENSG00000253561 GC08M133232
GH08F133340 0.7 Ensembl ENCODE 11.5 -39.4 -39361 2.4 ELF3 MXI1 TEAD1 NR2F1 FOXA3 TEAD4 CEBPB EP300 RAD21 TEAD3 NDRG1 RPL32P20 LOC105375772
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NDRG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NDRG1 Gene

Chromosome:
8
Start:
133,237,171 bp from pter
End:
133,302,022 bp from pter
Size:
64,852 bases
Orientation:
Minus strand

Genomic View for NDRG1 Gene

Genes around NDRG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NDRG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NDRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG1 Gene

Proteins for NDRG1 Gene

  • Protein details for NDRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92597-NDRG1_HUMAN
    Recommended name:
    Protein NDRG1
    Protein Accession:
    Q92597
    Secondary Accessions:
    • B3KR80
    • B7Z446
    • O15207
    • Q6IBG2
    • Q9NYR6
    • Q9UK29

    Protein attributes for NDRG1 Gene

    Size:
    394 amino acids
    Molecular mass:
    42835 Da
    Quaternary structure:
    • Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling of CDH1.

    Alternative splice isoforms for NDRG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDRG1 Gene

Post-translational modifications for NDRG1 Gene

  • Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NDRG1 (NDRG1)

No data available for DME Specific Peptides for NDRG1 Gene

Domains & Families for NDRG1 Gene

Protein Domains for NDRG1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q92597

UniProtKB/Swiss-Prot:

NDRG1_HUMAN :
  • Belongs to the NDRG family.
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG1: view

No data available for Gene Families for NDRG1 Gene

Function for NDRG1 Gene

Molecular function for NDRG1 Gene

UniProtKB/Swiss-Prot Function:
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.
UniProtKB/Swiss-Prot Induction:
By homocysteine, 2-mercaptoethanol, tunicamycin in endothelial cells. Induced approximately 20-fold during in vitro differentiation of the colon carcinoma cell lines HT-29-D4 and Caco-2. Induced by oxidative stress in colon cancers. Decreased expression in colon adenomas and adenocarcinomas. Induced by nickel compounds in all tested cell lines. The primary signal for its induction is an elevation of free intracellular calcium ion caused by nickel ion exposure. Okadaic acid, a serine/threonine phosphatase inhibitor, induced its expression more rapidly and more efficiently than nickel.

Gene Ontology (GO) - Molecular Function for NDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15607035
GO:0008017 microtubule binding IDA 15247272
GO:0017137 Rab GTPase binding IDA 17786215
GO:0043015 gamma-tubulin binding IDA 15247272
GO:0045296 cadherin binding IDA 17786215
genes like me logo Genes that share ontologies with NDRG1: view
genes like me logo Genes that share phenotypes with NDRG1: view

Human Phenotype Ontology for NDRG1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NDRG1 Gene

MGI Knock Outs for NDRG1:

Animal Model Products

miRNA for NDRG1 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NDRG1 Gene

Localization for NDRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDRG1 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDRG1 Gene COMPARTMENTS Subcellular localization image for NDRG1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
extracellular 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 9766676
GO:0005737 cytoplasm IEA,IDA 9766676
GO:0005813 centrosome IDA 15247272
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NDRG1: view

Pathways & Interactions for NDRG1 Gene

genes like me logo Genes that share pathways with NDRG1: view

SIGNOR curated interactions for NDRG1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010038 response to metal ion TAS 9605764
GO:0030330 DNA damage response, signal transduction by p53 class mediator IEP 9766676
GO:0032287 peripheral nervous system myelin maintenance IEA --
GO:0042127 regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with NDRG1: view

Drugs & Compounds for NDRG1 Gene

(9) Drugs for NDRG1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(5) Additional Compounds for NDRG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NDRG1: view

Transcripts for NDRG1 Gene

Unigene Clusters for NDRG1 Gene

N-myc downstream regulated 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - -
SP6: - - - -
SP7:
SP8: - - - - - - - - - - - - - - - - - - -
SP9: -
SP10: - - -
SP11:
SP12:
SP13:

ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6:
SP7: - -
SP8: - - - -
SP9: -
SP10:
SP11:
SP12: -
SP13: -

Relevant External Links for NDRG1 Gene

GeneLoc Exon Structure for
NDRG1
ECgene alternative splicing isoforms for
NDRG1

Expression for NDRG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NDRG1 Gene

Protein differential expression in normal tissues from HIPED for NDRG1 Gene

This gene is overexpressed in Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NDRG1 Gene



Protein tissue co-expression partners for NDRG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NDRG1 Gene:

NDRG1

SOURCE GeneReport for Unigene cluster for NDRG1 Gene:

Hs.372914

mRNA Expression by UniProt/SwissProt for NDRG1 Gene:

Q92597-NDRG1_HUMAN
Tissue specificity: Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.
genes like me logo Genes that share expression patterns with NDRG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NDRG1 Gene

Orthologs for NDRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDRG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NDRG1 34 35
  • 99.24 (n)
dog
(Canis familiaris)
Mammalia NDRG1 34 35
  • 91.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 91 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NDRG1 34 35
  • 89.5 (n)
mouse
(Mus musculus)
Mammalia Ndrg1 34 16 35
  • 86.38 (n)
rat
(Rattus norvegicus)
Mammalia Ndrg1 34
  • 86.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NDRG1 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDRG1 34 35
  • 76.57 (n)
lizard
(Anolis carolinensis)
Reptilia NDRG1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg1 34
  • 73.15 (n)
Str.9050 34
African clawed frog
(Xenopus laevis)
Amphibia ndr1-prov 34
zebrafish
(Danio rerio)
Actinopterygii ndrg1a 34 35
  • 70.28 (n)
ndrg1b 35
  • 61 (a)
OneToMany
ndrg1 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2582 34
fruit fly
(Drosophila melanogaster)
Insecta MESK2 36 35
  • 40 (a)
BcDNA:GH02439 36
  • 28 (a)
CG2082 35
  • 26 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 36 35
  • 30 (a)
ZK1073.1 35
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 35
  • 37 (a)
OneToMany
Species where no ortholog for NDRG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG1 Gene

ENSEMBL:
Gene Tree for NDRG1 (if available)
TreeFam:
Gene Tree for NDRG1 (if available)

Paralogs for NDRG1 Gene

Paralogs for NDRG1 Gene

genes like me logo Genes that share paralogs with NDRG1: view

Variants for NDRG1 Gene

Sequence variations from dbSNP and Humsavar for NDRG1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs119483085 Pathogenic 133,258,374(-) TAACT(C/T)GATTT reference, stop-gained
rs879254290 Pathogenic 133,250,456(-) TGTTC(-/C)ATCAA reference, frameshift-variant
rs369862936 Likely benign 133,280,262(+) CCGGT(G/T)ATGGT intron-variant, reference, synonymous-codon, utr-variant-5-prime
rs863224413 Likely benign 133,238,911(-) AACAG(C/T)GCCGG reference, synonymous-codon
rs139220402 Uncertain significance 133,258,385(+) GGATG(C/T)AGGCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NDRG1 Gene

Variant ID Type Subtype PubMed ID
nsv1140935 CNV deletion 24896259
nsv519775 CNV loss 19592680
nsv831464 CNV loss 17160897

Variation tolerance for NDRG1 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDRG1 Gene

Human Gene Mutation Database (HGMD)
NDRG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NDRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG1 Gene

Disorders for NDRG1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for NDRG1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 4d
  • charcot-marie-tooth disease type 4d
neuropathy, congenital hypomyelinating
  • neuropathy, congenital hypomyelinating, 1
central neurocytoma
  • neurolipocytoma
transitional papilloma
  • transitional cell papilloma
charcot-marie-tooth disease
  • hereditary motor and sensory neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search NDRG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NDRG1_HUMAN
  • Charcot-Marie-Tooth disease 4D (CMT4D) [MIM:601455]: A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. {ECO:0000269 PubMed:10831399}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NDRG1

Genetic Association Database (GAD)
NDRG1
Human Genome Epidemiology (HuGE) Navigator
NDRG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDRG1
genes like me logo Genes that share disorders with NDRG1: view

No data available for Genatlas for NDRG1 Gene

Publications for NDRG1 Gene

  1. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. (PMID: 9251681) van Belzen N. … Bosman F.T. (Lab. Invest. 1997) 2 3 4 22 64
  2. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. (PMID: 8939898) Kokame K. … Miyata T. (J. Biol. Chem. 1996) 2 3 4 22 64
  3. Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region. (PMID: 18455888) Zhang J. … Yao L. (Gene 2008) 2 3 22 64
  4. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. (PMID: 15247272) Kim K.T. … Lee S.W. (J. Biol. Chem. 2004) 3 4 22 64
  5. NDRG1 is necessary for p53-dependent apoptosis. (PMID: 15377670) Stein S. … Liang P. (J. Biol. Chem. 2004) 3 4 22 64

Products for NDRG1 Gene

Sources for NDRG1 Gene

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