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Aliases for NDRG1 Gene

Aliases for NDRG1 Gene

  • N-Myc Downstream Regulated 1 2 3
  • Reducing Agents And Tunicamycin-Responsive Protein 3 4
  • N-Myc Downstream-Regulated Gene 1 Protein 3 4
  • Nickel-Specific Induction Protein Cap43 3 4
  • Differentiation-Related Gene 1 Protein 3 4
  • RIT42 3 4
  • CAP43 3 4
  • DRG-1 3 4
  • DRG1 3 4
  • RTP 3 4
  • Protein Regulated By Oxygen-1 3
  • PROXY1 3
  • CMT4D 3
  • HMSNL 3
  • TARG1 3
  • NDR1 3
  • NMSL 3
  • TDD5 3
  • GC4 3

External Ids for NDRG1 Gene

Previous HGNC Symbols for NDRG1 Gene

  • CAP43

Previous GeneCards Identifiers for NDRG1 Gene

  • GC08M132979
  • GC08M134336
  • GC08M133920
  • GC08M134206
  • GC08M134318
  • GC08M129569
  • GC08M134249

Summaries for NDRG1 Gene

Entrez Gene Summary for NDRG1 Gene

  • This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for NDRG1 Gene

NDRG1 (N-Myc Downstream Regulated 1) is a Protein Coding gene. Diseases associated with NDRG1 include charcot-marie-tooth disease, type 4d and transitional papilloma. Among its related pathways are Angiogenesis (CST) and HIF-1-alpha transcription factor network. GO annotations related to this gene include microtubule binding and cadherin binding. An important paralog of this gene is NDRG2.

UniProtKB/Swiss-Prot for NDRG1 Gene

  • Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.

Gene Wiki entry for NDRG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NDRG1 Gene

Genomics for NDRG1 Gene

Regulatory Elements for NDRG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NDRG1 Gene

Chromosome:
8
Start:
133,237,171 bp from pter
End:
133,302,022 bp from pter
Size:
64,852 bases
Orientation:
Minus strand

Genomic View for NDRG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NDRG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NDRG1 Gene

Proteins for NDRG1 Gene

  • Protein details for NDRG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92597-NDRG1_HUMAN
    Recommended name:
    Protein NDRG1
    Protein Accession:
    Q92597
    Secondary Accessions:
    • B3KR80
    • B7Z446
    • O15207
    • Q6IBG2
    • Q9NYR6
    • Q9UK29

    Protein attributes for NDRG1 Gene

    Size:
    394 amino acids
    Molecular mass:
    42835 Da
    Quaternary structure:
    • Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling of CDH1.

    Alternative splice isoforms for NDRG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NDRG1 Gene

Proteomics data for NDRG1 Gene at MOPED

Post-translational modifications for NDRG1 Gene

  • Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NDRG1 (NDRG1)

No data available for DME Specific Peptides for NDRG1 Gene

Domains & Families for NDRG1 Gene

Protein Domains for NDRG1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q92597

UniProtKB/Swiss-Prot:

NDRG1_HUMAN :
  • Belongs to the NDRG family.
Family:
  • Belongs to the NDRG family.
genes like me logo Genes that share domains with NDRG1: view

No data available for Gene Families for NDRG1 Gene

Function for NDRG1 Gene

Molecular function for NDRG1 Gene

UniProtKB/Swiss-Prot Function:
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.
UniProtKB/Swiss-Prot Induction:
By homocysteine, 2-mercaptoethanol, tunicamycin in endothelial cells. Induced approximately 20-fold during in vitro differentiation of the colon carcinoma cell lines HT-29-D4 and Caco-2. Induced by oxidative stress in colon cancers. Decreased expression in colon adenomas and adenocarcinomas. Induced by nickel compounds in all tested cell lines. The primary signal for its induction is an elevation of free intracellular calcium ion caused by nickel ion exposure. Okadaic acid, a serine/threonine phosphatase inhibitor, induced its expression more rapidly and more efficiently than nickel.

Gene Ontology (GO) - Molecular Function for NDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15607035
GO:0008017 microtubule binding IDA 15247272
GO:0017137 Rab GTPase binding IDA 17786215
GO:0043015 gamma-tubulin binding IDA 15247272
GO:0045296 cadherin binding IDA 17786215
genes like me logo Genes that share ontologies with NDRG1: view
genes like me logo Genes that share phenotypes with NDRG1: view

Animal Models for NDRG1 Gene

MGI Knock Outs for NDRG1:

Animal Model Products

miRNA for NDRG1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDRG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NDRG1 Gene

Localization for NDRG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NDRG1 Gene

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NDRG1 Gene COMPARTMENTS Subcellular localization image for NDRG1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
extracellular 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 9766676
GO:0005737 cytoplasm IDA 9766676
GO:0005813 centrosome IDA 15247272
GO:0005829 cytosol IEA --
GO:0005874 microtubule IDA 15247272
genes like me logo Genes that share ontologies with NDRG1: view

Pathways & Interactions for NDRG1 Gene

genes like me logo Genes that share pathways with NDRG1: view

Pathways by source for NDRG1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for NDRG1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NDRG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IEA --
GO:0010038 response to metal ion TAS 9605764
GO:0030330 DNA damage response, signal transduction by p53 class mediator IEP 9766676
GO:0032287 peripheral nervous system myelin maintenance IEA --
GO:0042127 regulation of cell proliferation --
genes like me logo Genes that share ontologies with NDRG1: view

Drugs & Compounds for NDRG1 Gene

(7) Drugs for NDRG1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved Pharma 957
okadaic acid Experimental Pharma 0
Calcium Nutra 0
Cobalt Pharma 147
cysteine Nutra 143

(7) Additional Compounds for NDRG1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-MERCAPTOETHANOL
5,10-methenyltetrahydrofolate
COCl2
homocysteine
  • (+-)-homocysteine
  • (S)-2-amino-4-mercapto-Butanoate
  • (S)-2-amino-4-mercapto-Butanoic acid
  • 2-Amino-4-mercapto-Butanoate
  • 2-Amino-4-mercapto-Butanoic acid
454-29-5
Nickel
  • Carbonyl nickel powder
  • Malleable nickel
  • NI
  • Nichel
  • Nickel 200
7440-02-0
genes like me logo Genes that share compounds with NDRG1: view

Transcripts for NDRG1 Gene

Unigene Clusters for NDRG1 Gene

N-myc downstream regulated 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NDRG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NDRG1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - -
SP5: - -
SP6: - - - -
SP7:
SP8: - - - - - - - - - - - - - - - - - - -
SP9: -
SP10: - - -
SP11:
SP12:
SP13:

ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6:
SP7: - -
SP8: - - - -
SP9: -
SP10:
SP11:
SP12: -
SP13: -

Relevant External Links for NDRG1 Gene

GeneLoc Exon Structure for
NDRG1
ECgene alternative splicing isoforms for
NDRG1

Expression for NDRG1 Gene

mRNA expression in normal human tissues for NDRG1 Gene

Protein differential expression in normal tissues from HIPED for NDRG1 Gene

This gene is overexpressed in Salivary gland (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NDRG1 Gene



SOURCE GeneReport for Unigene cluster for NDRG1 Gene Hs.372914

mRNA Expression by UniProt/SwissProt for NDRG1 Gene

Q92597-NDRG1_HUMAN
Tissue specificity: Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.
genes like me logo Genes that share expression patterns with NDRG1: view

Protein tissue co-expression partners for NDRG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NDRG1 Gene

Orthologs for NDRG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NDRG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NDRG1 35
  • 89.5 (n)
  • 94.79 (a)
NDRG1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NDRG1 35
  • 91.23 (n)
  • 96.87 (a)
NDRG1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ndrg1 35
  • 86.38 (n)
  • 93.65 (a)
Ndrg1 16
Ndrg1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NDRG1 35
  • 99.24 (n)
  • 99.75 (a)
NDRG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ndrg1 35
  • 86.38 (n)
  • 93.4 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia NDRG1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves NDRG1 35
  • 76.57 (n)
  • 83.25 (a)
NDRG1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NDRG1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ndrg1 35
  • 73.15 (n)
  • 76.47 (a)
Str.9050 35
African clawed frog
(Xenopus laevis)
Amphibia ndr1-prov 35
zebrafish
(Danio rerio)
Actinopterygii ndrg1 35
ndrg1a 35
  • 70.28 (n)
  • 68.48 (a)
ndrg1a 36
  • 67 (a)
OneToMany
ndrg1b 36
  • 61 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2582 35
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH02439 37
  • 28 (a)
MESK2 37
  • 40 (a)
CG2082 36
  • 26 (a)
ManyToMany
MESK2 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea Y48G10A.3 37
  • 30 (a)
Y48G10A.3 36
  • 30 (a)
ManyToMany
ZK1073.1 36
  • 29 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7991 36
  • 37 (a)
OneToMany
Species with no ortholog for NDRG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NDRG1 Gene

ENSEMBL:
Gene Tree for NDRG1 (if available)
TreeFam:
Gene Tree for NDRG1 (if available)

Paralogs for NDRG1 Gene

Paralogs for NDRG1 Gene

genes like me logo Genes that share paralogs with NDRG1: view

Variants for NDRG1 Gene

Sequence variations from dbSNP and Humsavar for NDRG1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs10675 -- 133,237,743(-) GACCC(A/G)GTCAC utr-variant-3-prime
rs12668 -- 133,237,538(-) AGTGC(A/G)GCTGC utr-variant-3-prime
rs1011460 -- 133,257,695(+) ATATA(C/G)ATATG intron-variant, upstream-variant-2KB
rs1049694 -- 133,238,187(-) CAGGC(A/C/G/T)ACAAA utr-variant-3-prime
rs1049697 -- 133,237,922(-) GGGGG(C/T)GGAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NDRG1 Gene

Variant ID Type Subtype PubMed ID
nsv519775 CNV Loss 19592680
nsv831464 CNV Loss 17160897

Variation tolerance for NDRG1 Gene

Residual Variation Intolerance Score: 33.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NDRG1 Gene

HapMap Linkage Disequilibrium report
NDRG1
Human Gene Mutation Database (HGMD)
NDRG1

PCR Panel Products

  • Copy Number PCR Panels: for NDRG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NDRG1 Gene

Disorders for NDRG1 Gene

MalaCards: The human disease database

(11) MalaCards diseases for NDRG1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, type 4d
  • charcot-marie-tooth disease type 4d
transitional papilloma
  • transitional cell papilloma nos
charcot-marie-tooth neuropathy type 4
  • dejerine-sottas syndrome
motor peripheral neuropathy
  • hsmn - hereditary sensory and motor neuropathy
hereditary neuropathies
  • neuropathy - hereditary
- elite association
Search NDRG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NDRG1_HUMAN
  • Charcot-Marie-Tooth disease 4D (CMT4D) [MIM:601455]: A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. {ECO:0000269 PubMed:10831399}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for NDRG1

Genetic Association Database (GAD)
NDRG1
Human Genome Epidemiology (HuGE) Navigator
NDRG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NDRG1
genes like me logo Genes that share disorders with NDRG1: view

No data available for Genatlas for NDRG1 Gene

Publications for NDRG1 Gene

  1. Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region. (PMID: 18455888) Zhang J. … Yao L. (Gene 2008) 2 23 67
  2. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. (PMID: 9251681) van Belzen N. … Bosman F.T. (Lab. Invest. 1997) 2 23 67
  3. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. (PMID: 8939898) Kokame K. … Miyata T. (J. Biol. Chem. 1996) 2 23 67
  4. NDRG1/2 expression is inhibited in primary acute myeloid leukemia. (PMID: 19775754) Tschan M.P. … Fey M.F. (Leuk. Res. 2010) 23 67
  5. Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. (PMID: 20416281) Murakami Y. … Ono M. (Biochem. Biophys. Res. Commun. 2010) 23 67

Products for NDRG1 Gene

Sources for NDRG1 Gene

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