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NDRG1 Gene

protein-coding   GIFtS: 70
GCID: GC08M134249

N-Myc Downstream Regulated 1


(Previous symbol: CAP43)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
N-Myc Downstream Regulated 11 2     GC42
CAP431 2 3     NDR12
Differentiation-Related Gene 1 Protein2 3     NMSL2
Nickel-Specific Induction Protein Cap432 3     PROXY12
Reducing Agents And Tunicamycin-Responsive Protein2 3     RIT422
DRG-12 3     TARG12
DRG12 3     TDD52
RTP2 3     Protein NDRG12
N-Myc Downstream-Regulated Gene 1 Protein2 3     Protein Regulated By Oxygen-12
CMT4D2 5     Rit423
HMSNL2 5     

External Ids:    HGNC: 76791   Entrez Gene: 103972   Ensembl: ENSG000001044197   OMIM: 6052625   UniProtKB: Q925973   
ORGUL members:    fRNAdb10:FR367103      
H-InvDB12:HIT000074558    
NCBI13:AF230380    
RNAdb15:HIV1172    

Export aliases for NDRG1 gene to outside databases

Previous GC identifers: GC08M132979 GC08M134336 GC08M133920 GC08M134206 GC08M134318 GC08M129569


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NDRG1 Gene:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase
superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone
responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation
and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this
gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, May 2012)

GeneCards Summary for NDRG1 Gene:
NDRG1 (N-myc downstream regulated 1) is a protein-coding gene. Diseases associated with NDRG1 include neuropathy, hereditary motor and sensory, lom type, and charcot-marie-tooth neuropathy type 4d. GO annotations related to this gene include microtubule binding and cadherin binding. An important paralog of this gene is NDRG4.

UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597
Function: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a
tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and
apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and
development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also
function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent
mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy

Gene Wiki entry for NDRG1 Gene

fRNAdb sequence ontology for NDRG1:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for NDRG1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NDRG1 gene promoter:
         Egr-3   RFX1   Elk-1   ATF-2   FOXD3   Olf-1   Evi-1   Egr-2   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NDRG1 promoter sequence
   Search Chromatin IP Primers for NDRG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NDRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24

NDRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDRG1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M134249:  view genomic region     (about GC identifiers)

Start:
134,249,414 bp from pter      End:
134,314,265 bp from pter
Size:
64,852 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597 (See protein sequence)
Recommended Name: Protein NDRG1  
Size: 394 amino acids; 42835 Da
Subunit: Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling of CDH1
Secondary accessions: B3KR80 B7Z446 O15207 Q6IBG2 Q9NYR6 Q9UK29
Alternative splicing: 3 isoforms:  Q92597-1   Q92597-2   Q92597-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDRG1: NX_Q92597

Explore proteomics data for NDRG1 at MOPED

Post-translational modifications: 

  • Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in
    vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces
    dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NDRG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128714.1  NP_001245361.1  NP_001245362.1  NP_006087.2  

    ENSEMBL proteins: 
     ENSP00000319977   ENSP00000429172   ENSP00000404854   ENSP00000429007   ENSP00000427894  
     ENSP00000431057   ENSP00000429380   ENSP00000428345   ENSP00000428802   ENSP00000429994  
     ENSP00000429272   ENSP00000428384   ENSP00000429840   ENSP00000429524   ENSP00000428991  
     ENSP00000430171   ENSP00000347028   ENSP00000437443  

    NDRG1 Human Recombinant Protein Products:

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    OriGene Purified Proteins for NDRG1
    OriGene Protein Over-expression Lysate for NDRG1
    OriGene MassSpec for NDRG1
    OriGene Custom Protein Services for NDRG1
    GenScript Custom Purified and Recombinant Proteins Services for NDRG1
    Novus Biologicals NDRG1 Proteins
    Novus Biologicals NDRG1 Lysates
    Sino Biological Recombinant Protein for NDRG1
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NDRG1
    Cloud-Clone Corp. Proteins for NDRG1

    NDRG1 Antibody Products:

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    Abcam antibodies for NDRG1
    Cloud-Clone Corp. Antibodies for NDRG1
    ThermoFisher Antibodies for NDRG1
    LSBio Antibodies in human, mouse, rat for NDRG1

    NDRG1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NDRG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NDRG1
    Cloud-Clone Corp. CLIAs for NDRG1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004142 Ndr

    Graphical View of Domain Structure for InterPro Entry Q92597

    ProtoNet protein and cluster: Q92597

    1 Blocks protein domain: IPB004142 Ndr family

    UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597
    Similarity: Belongs to the NDRG family


    NDRG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NDRG1_HUMAN, Q92597
    Function: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a
    tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and
    apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and
    development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also
    function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent
    mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy
    Induction: By homocysteine, 2-mercaptoethanol, tunicamycin in endothelial cells. Induced approximately 20-fold
    during in vitro differentiation of the colon carcinoma cell lines HT-29-D4 and Caco-2. Induced by oxidative
    stress in colon cancers. Decreased expression in colon adenomas and adenocarcinomas. Induced by nickel compounds
    in all tested cell lines. The primary signal for its induction is an elevation of free intracellular calcium ion
    caused by nickel ion exposure. Okadaic acid, a serine/threonine phosphatase inhibitor, induced its expression
    more rapidly and more efficiently than nickel

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17220478
    GO:0008017microtubule binding IDA15247272
    GO:0017137Rab GTPase binding IDA17786215
    GO:0043015gamma-tubulin binding IDA15247272
    GO:0045296cadherin binding IDA17786215
         
    NDRG1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NDRG1:
     Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ndrg1):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  nervous system  tumorigenesis 
     vision/eye 

    NDRG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ndrg1tm1Myta for NDRG1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NDRG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NDRG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NDRG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NDRG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NDRG1:
    hsa-mir-335-5p (MIRT018414), hsa-mir-423-5p (MIRT038043), hsa-mir-34a-5p (MIRT025409), hsa-let-7b-5p (MIRT052351), hsa-mir-505-3p (MIRT041050)

    Block miRNA regulation of human, mouse, rat NDRG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NDRG1 (see all 26):
    hsa-miR-100* hsa-miR-34b* hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-1271
    SwitchGear 3'UTR luciferase reporter plasmidNDRG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NDRG1
    Predesigned siRNA for gene silencing in human, mouse, rat NDRG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NDRG1

    Clone
    Products:
         
    OriGene clones in human, mouse for NDRG1 (see all 12)
    OriGene ORF clones in mouse, rat for NDRG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NDRG1 (NM_006096)
    Sino Biological Human cDNA Clone for NDRG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDRG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDRG1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NDRG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NDRG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NDRG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NDRG1_HUMAN, Q92597: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with
    the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a
    p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the
    nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex,
    located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular
    cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes
    via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the
    centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres
    during S-phase of mitosis and with the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol5
    endosome5
    nucleus5
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9766676
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA15247272
    GO:0005829cytosol IEA--
    GO:0005874microtubule IDA15247272

    NDRG1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NDRG1 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1p53 Signaling
    p53 Pathway0.38
    2Prostate Cancer
    Prostate Cancer0.32
    3Wnt / Hedgehog / Notch
    Wnt / Hedgehog / Notch
    4Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression
    5PI3K / Akt Signaling
    PI3K / Akt Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Cell Signaling Technology (CST) Pathways for NDRG1 (see all 6)
        Wnt / Hedgehog / Notch
    Apoptosis and Autophagy
    Angiogenesis
    Neuroscience
    Lymphocyte Signaling

    4 BioSystems Pathways for NDRG1
        Prostate Cancer
    Direct p53 effectors
    HIF-1-alpha transcription factor network
    Validated targets of C-MYC transcriptional repression

    1 Sino Biological Pathway for NDRG1
        p53 Pathway



    NDRG1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including NDRG1: 
              Hypoxia Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NDRG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NDRG1 (Q925971, 3 ENSP000003199774) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129561, 3, ENSP000003522574EBI-716486,EBI-353208 I2D: score=2 STRING: ENSP00000352257
    CANXP278241, 3, ENSP000002474614EBI-716486,EBI-355947 I2D: score=3 STRING: ENSP00000247461
    ACSL3O955733, ENSP000003500124I2D: score=3 STRING: ENSP00000350012
    ATP1A1P050233, ENSP000002955984I2D: score=3 STRING: ENSP00000295598
    CLTCQ006103, ENSP000002691224I2D: score=3 STRING: ENSP00000269122
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010038response to metal ion TAS9605764
    GO:0030330DNA damage response, signal transduction by p53 class mediator IEP9766676
    GO:0032287peripheral nervous system myelin maintenance IEA--
    GO:0045576mast cell activation IEA--
    GO:0071456cellular response to hypoxia IEP--

    NDRG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NDRG1

    1 HMDB Compound for NDRG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for NDRG1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5,10-methenyltetrahydrofolate 83.2 1 9604001 (1)
    nickel 55.1 16 9605764 (4), 12767066 (2), 10646848 (2), 16707596 (1) (see all 7)
    2-mercaptoethanol 50.5 3 9701462 (1), 8939898 (1), 10049651 (1)
    cocl2 49.2 1 16622835 (1)
    tunicamycin 49.1 9 9701462 (2), 8939898 (2), 10049651 (2)
    threonine 37.9 4 18787837 (1), 9605764 (1), 10527911 (1)
    homocysteine 32.2 6 9701462 (2), 8939898 (2), 9605764 (1), 10049651 (1)
    okadaic acid 26.9 2 9605764 (1), 10527911 (1)
    cobalt 20.8 1 11006124 (1)
    iron 13.6 6 18029550 (2), 16920733 (2), 11006124 (1)



    NDRG1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for NDRG1 gene (4 alternative transcripts): 
    NM_001135242.1  NM_001258432.1  NM_001258433.1  NM_006096.3  

    Unigene Clusters for NDRG1:

    N-myc downstream regulated 1
    Hs.372914  [show with all ESTs], Hs.618002  [show with all ESTs]
    Unigene Representative Sequences: AK126924, CD252444
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000323851 ENST00000521438(uc003yui.1) ENST00000521026(uc003yue.1)
    ENST00000521414 ENST00000519278(uc003yuf.1) ENST00000517599 ENST00000414097(uc003yuh.2 uc003yug.2 uc010mee.2 uc010mef.2 uc011ljh.1 uc011lji.1)
    ENST00000518176 ENST00000522476 ENST00000518066 ENST00000523642 ENST00000522665
    ENST00000517331 ENST00000522377 ENST00000521664 ENST00000520230 ENST00000518010
    ENST00000518480
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NDRG1 (see all 26):
    hsa-miR-100* hsa-miR-34b* hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-1271
    SwitchGear 3'UTR luciferase reporter plasmidNDRG1 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for NDRG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NDRG1 (NM_006096)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NDRG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NDRG1
    Primer
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    OriGene qPCR primer pairs and template standards for NDRG1
    OriGene qSTAR qPCR primer pairs in human, mouse for NDRG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NDRG1
      QuantiTect SYBR Green Assays in human, mouse, rat NDRG1
      QuantiFast Probe-based Assays in human, mouse, rat NDRG1

    Additional mRNA sequence: AK130985.1 

    Selected DOTS entries (see all 50):

    DT.100889607  DT.95127200  DT.100042174  DT.100757848  DT.91861134  DT.95373904  DT.452886  DT.120641241 
    DT.95373908  DT.87014114  DT.99938052  DT.120641209  DT.100889577  DT.101985680  DT.86838305  DT.100042176 
    DT.120641177  DT.120641296  DT.99993615  DT.100889555  DT.120641138  DT.120641222  DT.120641232  DT.92459385 

    Selected AceView cDNA sequences (see all 858):

    BQ896590 AI675887 BM924390 CF243182 CA438313 BM664194 AA594681 CO248110 
    BQ879541 AW242130 AA375222 BI856742 AA639690 CD515319 AI300372 AA668951 
    CA441237 CD107848 CA396037 T91590 BM723619 W84352 BU542390 AA887511 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NDRG1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                                                          -                       -     -     -           -           -                     
    SP2:                          -                                               -                       -     -     -           -           -                     
    SP3:                          -                 -     -                       -                       -     -     -           -           -                     
    SP4:                          -                                               -                                                                                 
    SP5:                                                                                                                          -           -                     

    ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20
    SP1:        -                 -                     
    SP2:        -                 -                     
    SP3:        -                 -                     
    SP4:                                                
    SP5:        -                 -                     


    ECgene alternative splicing isoforms for NDRG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NDRG1 expression in normal human tissues (normalized intensities)      NDRG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGACTTTCCT
    NDRG1 Expression
    About this image


    NDRG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebellum
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Basal Cells Respiratory Bronchioles
    NDRG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NDRG1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.372914 Hs.618002

    UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597
    Tissue specificity: Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small
    intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low
    levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells.
    Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal
    tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression

        Pathway & Disease-focused RT2 Profiler PCR Array including NDRG1: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for NDRG1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ndrg11 , 5 N-myc downstream regulated gene 11, 5 86.38(n)1
    93.65(a)1
      15 (29.30 cM)5
    179881  NM_008681.21  NP_032707.21 
     669293215 
    chicken
    (Gallus gallus)
    Aves NDRG11 N-myc downstream regulated 1 76.57(n)
    83.25(a)
      420321  XM_418430.4  XP_418430.2 
    lizard
    (Anolis carolinensis)
    Reptilia NDRG16
    N-myc downstream regulated 1
    77(a)
    1 ↔ 1
    4(872073-964033)
    African clawed frog
    (Xenopus laevis)
    Amphibia ndr1-prov2 N-myc downstream regulated gene 1 76.73(n)    BC046693.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ndrg12 Danio rerio cDNA clone MGC63944 IMAGE6791251, complete more 76.71(n)    BC057420.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta MESK23   -- 40(a)
    (best of 2)
      57E8   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y48G10A.33   -- 30(a)   I(13479864-13482231)   --


    ENSEMBL Gene Tree for NDRG1 (if available)
    TreeFam Gene Tree for NDRG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NDRG1 gene
    NDRG42  NDRG22  NDRG32  
    4 SIMAP similar genes for NDRG1 using alignment to 14 protein entries:     NDRG1_HUMAN (see all proteins):
    TRG14    NDRG4    NDRG3    NDRG2

    NDRG1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for NDRG1 (see all 1460)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1194830851,2
    Cpathogenic1134544519(-) TAACTC/TGATTT 8 R * stg10--------
    rs1399209441,2
    C--129600846(+) TAAGT-/CA    
       
    /CACA
    CACAC
    4 -- int10--------
    rs558143711,2
    C--129600871(+) ACACA-/CA    
       
    /CACA
    ACAAA
    4 -- int10--------
    rs113377881,2
    C--129602509(+) AGCTT-/CAAGGA 4 -- int12Minor allele frequency- C:0.25NA CSA 4
    rs767741881,2
    C--129602509(+) AGCTTA/C/TAAGGA 4 -- int10--------
    rs2005706321,2
    --129605151(+) CACAC-/AAACACA 4 -- int10--------
    rs353774631,2
    C--129605153(+) CACAA-/ACACAGA 4 -- int11Minor allele frequency- AC:0.00CSA 2
    rs786087991,2
    C--129605154(+) ACAAAA/CACAGA 4 -- int10--------
    rs361263471,2
    C,F--129605240(+) TCCAAC/-AGAAA 4 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs726098941,2
    C--129605240(+) TCCAAA/CAGAAA 4 -- int10--------

    HapMap Linkage Disequilibrium report for NDRG1 (134249414 - 134314265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NDRG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831464CNV Loss17160897
    nsv519775CNV Loss19592680

    Human Gene Mutation Database (HGMD): NDRG1
    Locus Specific Mutation Databases (LSDB): NDRG1

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing NDRG1:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing NDRG1
    DNA2.0 Custom Variant and Variant Library Synthesis for NDRG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605262OMIM information: 148370 606129 606662 609259    
    OMIM disorders: 601455  
    UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597
  • Charcot-Marie-Tooth disease 4D (CMT4D) [MIM:601455]: A recessive demyelinating form of
    Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness
    and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth
    disease is classified in two main groups on the basis of electrophysiologic properties and histopathology:
    primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary
    peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve
    conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations
    on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow
    feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for NDRG1 (see all 57):    About MalaCards
    neuropathy, hereditary motor and sensory, lom type    charcot-marie-tooth neuropathy type 4d    motor peripheral neuropathy    charcot-marie-tooth neuropathy type 4
    charcot-marie-tooth disease type 4    central neurocytoma    hereditary neuropathies    tooth disease
    charcot-marie-tooth disease    cervical adenocarcinoma    peripheral neuropathy    axonal neuropathy
    polyneuropathy    neuropathy    lynch syndrome    prostate adenocarcinoma
    laryngeal squamous cell carcinoma    hypoxia    pancreatic cancer    esophagitis

    3 diseases from the University of Copenhagen DISEASES database for NDRG1:
    Peripheral neuropathy     Cancer     Charcot-Marie-Tooth disease

    NDRG1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NDRG1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hereditary neuropathy 69.8 1 15474366 (1)
    charcot-marie-tooth disease 56.3 2 12872253 (2)
    sensory neuropathy 54.8 2 12872253 (1), 19364063 (1)
    colorectal tumors 34.4 1 17569115 (1)
    metastasis 31.9 19 16920733 (5), 15184886 (2), 14966915 (2), 18281151 (2) (see all 10)
    tumors 31.2 43 16778198 (4), 19082468 (3), 14966915 (3), 16920733 (3) (see all 22)
    renal cancer 29.3 5 12767066 (3), 12429530 (1)
    cancer 27 27 17916902 (3), 16920733 (3), 12429530 (3), 19414333 (2) (see all 12)
    polyneuropathy 22.3 2 17142040 (2)
    pancreatic cancer 21.1 6 16778198 (4), 16832411 (1), 20416281 (1)

    GeneTests: NDRG1
    GeneReviews: NDRG1
    Genetic Association Database (GAD): NDRG1
    Human Genome Epidemiology (HuGE) Navigator: NDRG1 (6 documents)

    Export disorders for NDRG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NDRG1 gene, integrated from 10 sources (see all 181):
    (articles sorted by number of sources associating them with NDRG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. (PubMed id 9251681)1, 2, 3, 9 van Belzen N.... Bosman F.T. (Lab. Invest. 1997)
    2. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. (PubMed id 8939898)1, 2, 3, 9 Kokame K.... Miyata T. (J. Biol. Chem. 1996)
    3. Cap43, a novel gene specifically induced by Ni2+ compounds. (PubMed id 9605764)1, 2, 9 Zhou D.... Costa M. (Cancer Res. 1998)
    4. Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region. (PubMed id 18455888)1, 3, 9 Zhang J....Yao L. (Gene 2008)
    5. Expression of NDRG1, a differentiation-related gene, in human tissues. (PubMed id 12432451)1, 2, 9 Lachat P....Bosman F.T. (Histochem. Cell Biol. 2002)
    6. Mutation screening of the N-myc downstream-regulated gene 1 (NDRG1) in patients with Charcot-Marie-Tooth Disease. (PubMed id 12872253)1, 4, 9 Hunter M....Kalaydjieva L. (Hum. Mutat. 2003)
    7. NDRG1 is necessary for p53-dependent apoptosis. (PubMed id 15377670)1, 2, 9 Stein S.... Liang P. (J. Biol. Chem. 2004)
    8. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. (PubMed id 15247272)1, 2, 9 Kim K.T.... Lee S.W. (J. Biol. Chem. 2004)
    9. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. (PubMed id 10831399)1, 2, 9 Kalaydjieva L.... Thomas P.K. (Am. J. Hum. Genet. 2000)
    10. Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells. (PubMed id 10395947)1, 2, 9 Piquemal D.... Commes T. (Biochim. Biophys. Acta 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10397 HGNC: 7679 AceView: NDRG1 Ensembl:ENSG00000104419 euGenes: HUgn10397
    ECgene: NDRG1 H-InvDB: NDRG1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NDRG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NDRG1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=NDRG1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NDRG1 gene:
    Search GeneIP for patents involving NDRG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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