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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NDRG1 Gene

protein-coding   GIFtS: 68
GCID: GC08M134249

N-myc downstream regulated 1


(Previous symbol: CAP43)
 Explore 44 diseases affiliated with
NDRG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NDRG1    

Aliases
for NDRG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
N-Myc Downstream Regulated 11 2     CMT4D2 5
CAP431 2 3     HMSNL2 5
DRG11 2 3     GC42
RTP1 2 3     NMSL2
NDR11 2     PROXY12
TDD51 2     RIT422
Differentiation-Related Gene 1 Protein2 3     TARG12
Nickel-Specific Induction Protein Cap432 3     Protein NDRG12
Reducing Agents And Tunicamycin-Responsive Protein2 3     Protein Regulated By Oxygen-12
DRG-12 3     Rit423
N-Myc Downstream-Regulated Gene 1 Protein2 3     

External Ids:    HGNC: 76791   Entrez Gene: 103972   Ensembl: ENSG000001044197   OMIM: 6052625   UniProtKB: Q925973   

Export aliases for NDRG1 gene to outside databases

Previous GC identifers: GC08M132979 GC08M134336 GC08M133920 GC08M134206 GC08M134318 GC08M129569


Summaries
for NDRG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NDRG1:
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The
protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth,
and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in
this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic
indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, May 2012)

UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597
Function: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor
suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis.
Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of
the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid
trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle
checkpoint. Regulates microtubule dynamics and maintains euploidy

Gene Wiki entry for NDRG1


Genomic Views
for NDRG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NDRG1 gene promoter:
         Egr-3   RFX1   Elk-1   ATF-2   FOXD3   Olf-1   Evi-1   Egr-2   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NDRG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NDRG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NDRG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24

NDRG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NDRG1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M134249:  view genomic region     (about GC identifiers)

Start:
 134,249,414 bp from pter      End:
 134,314,265 bp from pter
Size:
 64,852 bases      Orientation:
 minus strand

Proteins
for NDRG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597 (See protein sequence)
Recommended Name: Protein NDRG1  
Size: 394 amino acids; 42835 Da
Subunit: Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling of CDH1
Subcellular location: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, centrosome. Nucleus. Cell membrane. Note=Mainly
cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia
and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and
placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium
cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions.
Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the
membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with
microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated
form found associated with centromeres during S-phase of mitosis and with the plasma membrane
Secondary accessions: B3KR80 B7Z446 O15207 Q6IBG2 Q9NYR6 Q9UK29
Alternative splicing: 3 isoforms:  Q92597-1   Q92597-2   Q92597-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NDRG1: NX_Q92597

Post-translational modifications:

  • Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in
    • vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation.
    Phosphorylation by SGK1 is cell cycle dependent1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92597

    • NDRG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001128714.1  NP_001245361.1  NP_001245362.1  NP_006087.2  

    ENSEMBL proteins: 
     ENSP00000319977   ENSP00000429172   ENSP00000404854   ENSP00000429007   ENSP00000427894  
     ENSP00000431057   ENSP00000429380   ENSP00000428345   ENSP00000428802   ENSP00000429994  
     ENSP00000429272   ENSP00000428384   ENSP00000429840   ENSP00000429524   ENSP00000428991  
     ENSP00000430171   ENSP00000347028   ENSP00000437443  

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    ProSpec Recombinant Protein for NDRG1
    Uscn Proteins for NDRG1

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA9766676
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA15247272
    GO:0005829cytosol IEA--
    GO:0005874microtubule IDA15247272


    NDRG1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NDRG1

    Protein Domains /
    Families
    for NDRG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NDRG1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR004142 Ndr

    Graphical View of Domain Structure for InterPro Entry Q92597

    ProtoNet protein and cluster: Q92597

    1 Blocks protein family: IPB004142 Ndr family

    UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597
    Similarity: Belongs to the NDRG family


    Function
    for NDRG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597
    Function: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor
    suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis.
    Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of
    the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid
    trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle
    checkpoint. Regulates microtubule dynamics and maintains euploidy
    Induction: By homocysteine, 2-mercaptoethanol, tunicamycin in endothelial cells. Induced approximately 20-fold during
    in vitro differentiation of the colon carcinoma cell lines HT-29-D4 and Caco-2. Induced by oxidative stress in colon
    cancers. Decreased expression in colon adenomas and adenocarcinomas. Induced by nickel compounds in all tested cell
    lines. The primary signal for its induction is an elevation of free intracellular calcium ion caused by nickel ion
    exposure. Okadaic acid, a serine/threonine phosphatase inhibitor, induced its expression more rapidly and more
    efficiently than nickel

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    SwitchGear 3'UTR luciferase reporter plasmid: NDRG1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17220478
    GO:0008017microtubule binding IDA15247272
    GO:0017137Rab GTPase binding IDA17786215
    GO:0043015gamma-tubulin binding IDA15247272
    GO:0045296cadherin binding IDA17786215


    NDRG1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NDRG1:
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Ndrg1tm1Myta for NDRG1
         11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ndrg1):
     behavior/neurological  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  muscle  nervous system  tumorigenesis 
     vision/eye 

    NDRG1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NDRG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Wnt / Hedgehog / Notch
    		Wnt / Hedgehog / Notch1.00
    2Neuroscience
    		Neuroscience1.00
    3Lymphocyte Signaling
    		Lymphocyte Signaling1.00
    4Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    5Angiogenesis
    		Angiogenesis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6 Cell Signaling Technology (CST) Pathways for NDRG1 (see all 6)
        Wnt / Hedgehog / Notch
    Apoptosis and Autophagy
    Angiogenesis
    Neuroscience
    Lymphocyte Signaling

    3 BioSystems Pathways for NDRG1 
        Direct p53 effectors
    Validated targets of C-MYC transcriptional repression
    HIF-1-alpha transcription factor network



    NDRG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NDRG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/102 Interacting proteins for NDRG1 (Q925971, 3 ENSP000003199774) via UniProtKB, MINT, STRING, and/or I2D (see all 102)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129561, 3, ENSP000003522574EBI-716486,EBI-2843064 I2D: score=2 STRING: ENSP00000352257
    CANXP278241, 3, ENSP000002474614EBI-716486,EBI-355947 I2D: score=3 STRING: ENSP00000247461
    ACSL3O955733, ENSP000003500124I2D: score=3 STRING: ENSP00000350012
    ATP1A1P050233, ENSP000002955984I2D: score=3 STRING: ENSP00000295598
    CLTCQ006103, ENSP000002691224I2D: score=3 STRING: ENSP00000269122
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010038response to metal ion TAS9605764
    GO:0030330DNA damage response, signal transduction by p53 class mediator IEP9766676
    GO:0032287peripheral nervous system myelin maintenance IEA--
    GO:0045576mast cell activation IEA--
    GO:0071456cellular response to hypoxia IEP--


    NDRG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NDRG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NDRG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NDRG1

    1 HMDB Compound for NDRG1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/14 Novoseek chemical compound relationships for NDRG1 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    5,10-methenyltetrahydrofolate 83.2 1 9604001 (1)
    nickel 55.1 16 9605764 (4), 12767066 (2), 10646848 (2), 16707596 (1) (see all 7)
    2-mercaptoethanol 50.5 3 9701462 (1), 8939898 (1), 10049651 (1)
    cocl2 49.2 1 16622835 (1)
    tunicamycin 49.1 9 9701462 (2), 8939898 (2), 10049651 (2)
    threonine 37.9 4 18787837 (1), 9605764 (1), 10527911 (1)
    homocysteine 32.2 6 9701462 (2), 8939898 (2), 9605764 (1), 10049651 (1)
    okadaic acid 26.9 2 9605764 (1), 10527911 (1)
    cobalt 20.8 1 11006124 (1)
    iron 13.6 6 18029550 (2), 16920733 (2), 11006124 (1)

    Search CenterWatch for drugs/clinical trials and news about NDRG1 

    Transcripts
    for NDRG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NDRG1 gene (4 alternative transcripts): 
    NM_001135242.1  NM_001258432.1  NM_001258433.1  NM_006096.3  

    Unigene Clusters for NDRG1:

    N-myc downstream regulated 1
    Hs.372914  [show with all ESTs], Hs.618002  [show with all ESTs]
    Unigene Representative Sequences: AK126924, CD252444
    18/30 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 30):
    ENST00000323851 ENST00000521438(uc003yui.1) ENST00000521026(uc003yue.1)
    ENST00000521414 ENST00000519278(uc003yuf.1) ENST00000517599 ENST00000414097(uc003yuh.2 uc003yug.2 uc010mee.2 uc010mef.2 uc011ljh.1 uc011lji.1)
    ENST00000518176 ENST00000522476 ENST00000518066 ENST00000523642 ENST00000522665
    ENST00000517331 ENST00000522377 ENST00000521664 ENST00000520230 ENST00000518010
    ENST00000518480

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    hsa-miR-100* hsa-miR-34b* hsa-miR-875-3p hsa-miR-520d-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-1271
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    Inhib. RNA
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    Additional cDNA sequence: AK130985.1 

    24/50 DOTS entries (see all 50):

    DT.100889607  DT.95127200  DT.100042174  DT.100757848  DT.91861134  DT.95373904  DT.452886  DT.120641241 
    DT.95373908  DT.87014114  DT.99938052  DT.120641209  DT.100889577  DT.101985680  DT.86838305  DT.100042176 
    DT.99993615  DT.120641177  DT.120641296  DT.100889555  DT.120641138  DT.120641232  DT.92459385  DT.95228467 

    24/858 AceView cDNA sequences (see all 858):

    AI497801 AA970848 BM505523 AW149163 AA594681 CD244015 AA962191 BM722304 
    CD107848 BM985398 N48509 CA441237 T91590 BQ285970 AI498983 AF147402 
    BF446290 BU752125 BP376470 AI371683 AF230380 BQ919026 BM924390 BU621900 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for NDRG1 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16a ·
    SP1:                                                                          -                       -     -     -           -           -                     
    SP2:                          -                                               -                       -     -     -           -           -                     
    SP3:                          -                 -     -                       -                       -     -     -           -           -                     
    SP4:                          -                                               -                                                                                 
    SP5:                                                                                                                          -           -                     

    ExUns: 16b ^ 17a · 17b ^ 18 ^ 19a · 19b · 19c ^ 20
    SP1:        -                 -                     
    SP2:        -                 -                     
    SP3:        -                 -                     
    SP4:                                                
    SP5:        -                 -                     


    ECgene alternative splicing isoforms for NDRG1

    Expression
    for NDRG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NDRG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGACTTTCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NDRG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    LiverLiver LobulePerivenous HepatocytesLiver
    LungRespiratory BronchiolesBasal CellsLung
    OvaryAntral FollicleCumulus CellsOvary
    BrainCerebral CortexBrain
    BrainMeningesBrain
    Gut TubeMidgutGut Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle

    See NDRG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NDRG1

    SOURCE GeneReport for Unigene clusters: Hs.372914 Hs.618002

    UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597
    Tissue specificity: Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small
    intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in
    peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in
    Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon,
    prostate and placental membranes, the cells that border the lumen show the highest expression

        SABiosciences Expression via Pathway-Focused PCR Array including NDRG1: 
              Hypoxia Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for NDRG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NDRG1 gene from 9/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ndrg11 , 5 N-myc downstream regulated gene 11, 5 86.38(n)1
    93.65(a)1    		   15 (29.30 cM)5
    179881  NM_008681.21  NP_032707.21 
     669293215 
    chicken
    (Gallus gallus)    		 Aves NDRG11 N-myc downstream regulated 1 76.57(n)
    83.25(a)    		   420321  XM_418430.3  XP_418430.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NDRG16
    		 --
    		 79(a)
    		 1 ↔ 1
    		 4(876459-901198)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ndr1-prov2 N-myc downstream regulated gene 1 76.73(n)    BC046693.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ndrg12 Danio rerio cDNA clone MGC63944 IMAGE6791251, complete more 76.71(n)    BC057420.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta MESK23   -- 40(a)
    (best of 2)    		   57E8   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y48G10A.33   -- 30(a)   I(13479864-13482231)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons NDL21 protein N-MYC downregulated-like 2 42.77(n)
    31.54(a)    		   831051  NM_121217.2  NP_568251.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 pollen-specific protein SF21, putative, expressed
    (see all 4)    		 26(a)
    26(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 2(7006064-7010651)
    6(21636462-21640998)


    ENSEMBL Gene Tree for NDRG1 (if available)
    TreeFam Gene Tree for NDRG1 (if available) 

    Paralogs
    for NDRG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NDRG1 gene
    NDRG22  NDRG42  NDRG32  
    4 SIMAP similar genes for NDRG1 using alignment to 14 protein entries:     NDRG1_HUMAN (see all proteins):
    TRG14    NDRG4    NDRG3    NDRG2

    NDRG1 for paralogs           About GeneDecksing



    Genomic Variants
    for NDRG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1204 NCBI SNPs in NDRG1 are shown (see all 1204)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1194830851,2
    		Cpathogenic131990109(-) TAACTC/TGATTT 8 R * stg10--------
    rs78433291,2
    		C,F,A,H,--129568967(+) GCCACT/CGGGAA 4 -- ds500116Minor allele frequency- C:0.05NS EA NA WA 1632
    rs78253781,2
    		C,F,H,--129569086(+) CCCCCC/GAGTGA 4 -- ds50016Minor allele frequency- G:0.05NS EA WA 534
    rs78254391,2
    		C,F,H,--129569243(+) ACAATA/CGTTTC 4 -- ut3111Minor allele frequency- C:0.06NS EA NA WA 1214
    rs106751,2
    		C,F,O,H,--129569730(-) GACCCG/AGTCAC 4 -- ut31 ese312Minor allele frequency- A:0.04MN NS EA NA WA 1532
    rs169048651,2
    		C,F,H,--129569999(+) AGGAAT/AGCAAA 4 -- ut31 ese38Minor allele frequency- A:0.02NA NS EA WA 676
    rs792813241,2
    		C,--129570031(+) CCTGAA/TCAAGA 4 -- ut313Minor allele frequency- T:0.13CSA WA 121
    rs169048661,2
    		C,F,H,--129570154(+) TGTCTG/ATAAAG 4 -- ut31 ese316Minor allele frequency- A:0.08NA NS EA WA 1632
    rs46378021,2
    		H--129570486(+) CTTCTG/AACCAG 4 -- ut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs737118341,2
    		C,--129570601(+) GAGGAG/CAGTGG 4 -- ut312Minor allele frequency- C:0.10WA 120

    HapMap Linkage Disequilibrium report for NDRG1 (134249414 - 134314265 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NDRG1
         1 CNV: 52380
    Human Gene Mutation Database (HGMD): NDRG1

    Locus Specific Mutation Databases (LSDB): NDRG1

    SABiosciences Cancer Mutation PCR Assays
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    Ovarian Cancer
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    DNA2.0 Custom Variant and Variant Library Synthesis for NDRG1

    Disorders / Diseases
    for NDRG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NDRG1 for disorders           About GeneDecksing

    OMIM gene information: 605262   
    OMIM disorders: 601455  
    UniProtKB/Swiss-Prot: NDRG1_HUMAN, Q92597
  • Defects in NDRG1 are the cause of Charcot-Marie-Tooth disease type 4D (CMT4D) [MIM:601455]; also known as
    • hereditary motor and sensory neuropathy Lom type (HMSNL). CMT4D is a recessive form of Charcot-Marie-Tooth disease,
    the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two
    main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating
    neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely
    reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb
    formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and
    hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4

    20/44 diseases for NDRG1 (see all 44):    About MalaCards
    charcot-marie-tooth disease type 4    charcot-marie-tooth disease    charcot-marie-tooth neuropathy    tooth disease
    charcot-marie-tooth neuropathy type 4    motor peripheral neuropathy    peripheral neuropathy    neuropathy
    hereditary neuropathies    axonal neuropathy    esophageal squamous cell carcinoma    squamous cell carcinoma
    polyneuropathy    renal cell carcinoma    colon carcinoma    colon cancer
    hepatitis c    cervical adenocarcinoma    pancreatic cancer    carcinoma

    3 diseases from the University of Copenhagen DISEASES database for NDRG1:
    Peripheral neuropathy     Cancer     Charcot-Marie-Tooth disease

    10/22 Novoseek disease relationships for NDRG1 gene (see all 22)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hereditary neuropathy 69.8 1 15474366 (1)
    charcot-marie-tooth disease 56.3 2 12872253 (2)
    sensory neuropathy 54.8 2 12872253 (1), 19364063 (1)
    colorectal tumors 34.4 1 17569115 (1)
    metastasis 31.9 19 16920733 (5), 15184886 (2), 14966915 (2), 18281151 (2) (see all 10)
    tumors 31.2 43 16778198 (4), 19082468 (3), 14966915 (3), 16920733 (3) (see all 22)
    renal cancer 29.3 5 12767066 (3), 12429530 (1)
    cancer 27 27 17916902 (3), 16920733 (3), 12429530 (3), 19414333 (2) (see all 12)
    polyneuropathy 22.3 2 17142040 (2)
    pancreatic cancer 21.1 6 16778198 (4), 16832411 (1), 20416281 (1)

    GeneTests: NDRG1
    Charcot-Marie-Tooth Neuropathy Type 4

    Genetic Association Database (GAD): NDRG1
    Human Genome Epidemiology (HuGE) Navigator: NDRG1 (6 documents)

    Export disorders for NDRG1 gene to outside databases

    Publications
    for NDRG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NDRG1 gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with NDRG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene which is up-regulated during colon epithelial cell differentiation and down-regulated in colorectal neoplasms. (PubMed id 9251681)1, 2, 3, 9 van Belzen N.... Bosman F.T. (1997)
    2. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. (PubMed id 8939898)1, 2, 3, 9 Kokame K.... Miyata T. (1996)
    3. Cap43, a novel gene specifically induced by Ni2+ compounds. (PubMed id 9605764)1, 2, 9 Zhou D.... Costa M. (1998)
    4. Human differentiation-related gene NDRG1 is a Myc dow nstream-regulated gene that is repressed by Myc on the core promoter region. (PubMed id 18455888)1, 3, 9 Zhang J....Yao L. (2008)
    5. Expression of NDRG1, a differentiation-related gene, in human tissues. (PubMed id 12432451)1, 2, 9 Lachat P....Bosman F.T. (2002)
    6. Mutation screening of the N-myc downstream-regulated gene 1 (NDRG1) in patients with Charcot-Marie-Tooth Disease. (PubMed id 12872253)1, 4, 9 Hunter M....Kalaydjieva L. (2003)
    7. NDRG1 is necessary for p53-dependent apoptosis. (PubMed id 15377670)1, 2, 9 Stein S....Liang P. (2004)
    8. Function of Drg1/Rit42 in p53-dependent mitotic spindle checkpoint. (PubMed id 15247272)1, 2, 9 Kim K.T....Lee S.W. (2004)
    9. N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. (PubMed id 10831399)1, 2, 9 Kalaydjieva L.... Thomas P.K. (2000)
    10. Differential expression of the RTP/Drg1/Ndr1 gene product in proliferating and growth arrested cells. (PubMed id 10395947)1, 2, 9 Piquemal D.... Commes T. (1999)

    External Searches for NDRG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NDRG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10397 HGNC: 7679 AceView: NDRG1 Ensembl:ENSG00000104419 euGenes: HUgn10397
    ECgene: NDRG1 H-InvDB: NDRG1

    Other Databases showing NDRG1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NDRG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NDRG1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NDRG1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NDRG1

    Intellectual Property
    for NDRG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NDRG1 gene:
    Search GeneIP for patents involving NDRG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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